IMP: Integrative Multi-species Prediction

Mus musculus

90 known processes

Serpina1b

serine (or cysteine) preptidase inhibitor, clade A, member 1B

(Aliases: Spi1-2,D12Ucla2,PI2,Dom2,MGC117839)

Ensembl: ENSMUSG00000071178
Entrez: 20701
UniProtKB: P22599

Process Predictions
Disease Predictions

Serpina1b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of insulin receptor signaling pathway	GO:0046628	4	0.586	Mouse
regulation of protein kinase c activity	GO:1900019	1	0.585	Mouse
ovarian follicle rupture	GO:0001543	2	0.537	Mouse
positive regulation of protein kinase c activity	GO:1900020	1	0.531	Mouse
regulation of cholesterol metabolic process	GO:0090181	14	0.479	Mouse
regulation of renal output by angiotensin	GO:0002019	2	0.372	Mouse
neutral lipid metabolic process	GO:0006638	57	0.354	Mouse
negative regulation of serine type endopeptidase activity	GO:1900004	2	0.348	Rat
activation of nf kappab inducing kinase activity	GO:0007250	4	0.346	Mouse
acylglycerol metabolic process	GO:0006639	55	0.341	Mouse
triglyceride metabolic process	GO:0006641	51	0.333	Mouse
macromolecule glycosylation	GO:0043413	55	0.316
response to chromate	GO:0046687	1	0.312	Rat
sterol metabolic process	GO:0016125	58	0.300	Mouse
renin angiotensin regulation of aldosterone production	GO:0002018	3	0.298	Mouse
astrocyte activation	GO:0048143	2	0.276	Mouse
amine metabolic process	GO:0009308	45	0.270
protein glycosylation	GO:0006486	55	0.256
cellular amino acid metabolic process	GO:0006520	103	0.219
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	GO:0001998	3	0.217	Mouse
alcohol metabolic process	GO:0006066	116	0.216	Mouse
regulation of fatty acid biosynthetic process	GO:0042304	12	0.208	Mouse
glycerolipid metabolic process	GO:0046486	122	0.207	Mouse
glycosylation	GO:0070085	62	0.199
hexose metabolic process	GO:0019318	98	0.199	Mouse
carboxylic acid biosynthetic process	GO:0046394	86	0.193	Mouse
regulation of insulin receptor signaling pathway	GO:0046626	21	0.189	Mouse
carbohydrate metabolic process	GO:0005975	230	0.187
negative regulation of lipid metabolic process	GO:0045833	30	0.184	Mouse
cellular lipid metabolic process	GO:0044255	323	0.178	Mouse
cellular amine metabolic process	GO:0044106	44	0.177
regulation of cellular amine metabolic process	GO:0033238	20	0.174
protein n linked glycosylation	GO:0006487	12	0.169
regulation of cellular amino acid metabolic process	GO:0006521	5	0.168
cholesterol metabolic process	GO:0008203	56	0.164	Mouse
regulation of hydrolase activity	GO:0051336	246	0.163
positive regulation of fatty acid biosynthetic process	GO:0045723	3	0.159	Mouse
fatty acid metabolic process	GO:0006631	121	0.145	Mouse
lipid biosynthetic process	GO:0008610	179	0.141	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.138
negative regulation of protein metabolic process	GO:0051248	282	0.137
regulation of cellular ketone metabolic process	GO:0010565	66	0.132	Mouse
protein maturation	GO:0051604	176	0.130
organic acid biosynthetic process	GO:0016053	86	0.129	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.129
peptidyl amino acid modification	GO:0018193	336	0.127	Mouse
negative regulation of protein processing	GO:0010955	79	0.127
regulation of triglyceride metabolic process	GO:0090207	17	0.126	Mouse
hexose biosynthetic process	GO:0019319	39	0.125	Mouse
negative regulation of hydrolase activity	GO:0051346	71	0.124
protein processing	GO:0016485	163	0.121
regulation of fatty acid metabolic process	GO:0019217	28	0.120	Mouse
regulation of protein maturation	GO:1903317	96	0.119
glycoprotein metabolic process	GO:0009100	116	0.119
extracellular structure organization	GO:0043062	148	0.119	Mouse
regulation of inflammatory response	GO:0050727	147	0.118	Mouse
glucose metabolic process	GO:0006006	92	0.117	Mouse
protein secretion	GO:0009306	111	0.117	Mouse
monocarboxylic acid metabolic process	GO:0032787	191	0.116	Mouse
regulation of peptidase activity	GO:0052547	96	0.115
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.110	Mouse
regulation of endopeptidase activity	GO:0052548	89	0.110
fatty acid biosynthetic process	GO:0006633	41	0.109	Mouse
cellular carbohydrate metabolic process	GO:0044262	119	0.106	Mouse
inflammatory response	GO:0006954	244	0.106	Mouse Rat
hormone metabolic process	GO:0042445	86	0.105	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.102
regulation of protein processing	GO:0070613	96	0.101
organic hydroxy compound metabolic process	GO:1901615	203	0.100	Mouse
negative regulation of endopeptidase activity	GO:0010951	44	0.100
response to peptide	GO:1901652	136	0.098
cellular response to organonitrogen compound	GO:0071417	145	0.096	Mouse
regulation of cytokine production	GO:0001817	266	0.095	Mouse
regulation of glucose metabolic process	GO:0010906	60	0.095	Mouse
negative regulation of molecular function	GO:0044092	258	0.094
positive regulation of protein phosphorylation	GO:0001934	242	0.093	Mouse
negative regulation of proteolysis	GO:0045861	74	0.092
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.091	Mouse
regulation of defense response	GO:0031347	233	0.091	Mouse
cell matrix adhesion	GO:0007160	68	0.090	Mouse
muscle cell differentiation	GO:0042692	261	0.089	Mouse
negative regulation of gluconeogenesis	GO:0045721	9	0.089	Mouse
small molecule biosynthetic process	GO:0044283	132	0.085	Mouse
positive regulation of protein modification process	GO:0031401	299	0.085	Mouse
steroid metabolic process	GO:0008202	119	0.084	Mouse
urogenital system development	GO:0001655	261	0.083	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.082	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.082	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.082	Mouse
cellular ketone metabolic process	GO:0042180	84	0.081	Mouse
oxidation reduction process	GO:0055114	342	0.080
smooth muscle contraction	GO:0006939	44	0.079	Mouse
negative regulation of protein maturation	GO:1903318	79	0.078
regulation of transferase activity	GO:0051338	263	0.078	Mouse
regulation of kinase activity	GO:0043549	249	0.078	Mouse
inositol lipid mediated signaling	GO:0048017	41	0.077	Mouse
cellular response to insulin stimulus	GO:0032869	78	0.077	Mouse
monosaccharide metabolic process	GO:0005996	106	0.076	Mouse
monocarboxylic acid biosynthetic process	GO:0072330	61	0.076	Mouse
response to peptide hormone	GO:0043434	127	0.074
cell substrate adhesion	GO:0031589	130	0.071	Mouse
extracellular matrix organization	GO:0030198	147	0.071	Mouse
renal system development	GO:0072001	225	0.069	Mouse
mapk cascade	GO:0000165	281	0.069	Mouse
regulation of proteolysis	GO:0030162	164	0.068
cellular response to hormone stimulus	GO:0032870	150	0.067	Mouse
spermatogenesis	GO:0007283	284	0.066	Mouse
regulation of protein localization	GO:0032880	231	0.064	Mouse
female sex differentiation	GO:0046660	84	0.063	Mouse
regulation of carbohydrate metabolic process	GO:0006109	75	0.063	Mouse
muscle system process	GO:0003012	141	0.063	Mouse
regulation of systemic arterial blood pressure by circulatory renin angiotensin	GO:0001991	13	0.062	Mouse
blood circulation	GO:0008015	195	0.062	Mouse
renal tubule development	GO:0061326	87	0.061	Mouse
regulation of protein kinase activity	GO:0045859	232	0.061	Mouse
negative regulation of cellular carbohydrate metabolic process	GO:0010677	19	0.059	Mouse
regulation of mapk cascade	GO:0043408	248	0.059	Mouse
ovulation cycle	GO:0042698	59	0.058	Mouse
nephron morphogenesis	GO:0072028	69	0.058	Mouse
rhythmic process	GO:0048511	174	0.057	Mouse
glucocorticoid metabolic process	GO:0008211	9	0.057	Mouse
regulation of protein transport	GO:0051223	163	0.057	Mouse
response to insulin	GO:0032868	100	0.057	Mouse
cellular response to peptide hormone stimulus	GO:0071375	92	0.057	Mouse
circulatory system process	GO:0003013	197	0.056	Mouse
cellular response to peptide	GO:1901653	92	0.056	Mouse
cell adhesion	GO:0007155	329	0.055	Mouse
negative regulation of peptidase activity	GO:0010466	46	0.055
regulation of phosphatidylinositol 3 kinase signaling	GO:0014066	30	0.055	Mouse
regulation of tube size	GO:0035150	57	0.055	Mouse
regulation of protein secretion	GO:0050708	82	0.055	Mouse
cytokine production	GO:0001816	319	0.055	Mouse
peptidyl serine modification	GO:0018209	83	0.054	Mouse
response to acid chemical	GO:0001101	111	0.054	Rat
female gonad development	GO:0008585	71	0.053	Mouse
renal system process	GO:0003014	48	0.053	Mouse
regulation of blood vessel size	GO:0050880	56	0.053	Mouse
nephron epithelium development	GO:0072009	92	0.053	Mouse
phosphatidylinositol 3 kinase signaling	GO:0014065	36	0.052	Mouse
cytokine secretion	GO:0050663	72	0.052	Mouse
nephron epithelium morphogenesis	GO:0072088	68	0.052	Mouse
positive regulation of transferase activity	GO:0051347	167	0.051	Mouse
response to organic cyclic compound	GO:0014070	198	0.051	Rat
regulation of hormone levels	GO:0010817	211	0.051	Mouse
positive regulation of protein transport	GO:0051222	93	0.051	Mouse
regulation of protein serine threonine kinase activity	GO:0071900	157	0.051	Mouse
carbohydrate biosynthetic process	GO:0016051	74	0.051	Mouse
response to molecule of bacterial origin	GO:0002237	143	0.051	Rat
positive regulation of kinase activity	GO:0033674	155	0.050	Mouse
ras protein signal transduction	GO:0007265	77	0.050
mesonephric tubule development	GO:0072164	94	0.050	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.050
negative regulation of neuron death	GO:1901215	98	0.050	Mouse
regulation of secretion	GO:0051046	274	0.050	Mouse
ureteric bud morphogenesis	GO:0060675	62	0.049	Mouse
vascular process in circulatory system	GO:0003018	62	0.049	Mouse
positive regulation of secretion	GO:0051047	130	0.049	Mouse
development of primary female sexual characteristics	GO:0046545	73	0.049	Mouse
kidney development	GO:0001822	213	0.049	Mouse
nephron development	GO:0072006	109	0.049	Mouse
regulation of secretion by cell	GO:1903530	249	0.047	Mouse
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure	GO:0001999	6	0.047	Mouse
astrocyte development	GO:0014002	12	0.047	Mouse
response to inorganic substance	GO:0010035	96	0.047	Rat
monosaccharide biosynthetic process	GO:0046364	44	0.046	Mouse
reactive nitrogen species metabolic process	GO:2001057	0	0.046
epithelial cell development	GO:0002064	159	0.046	Mouse
positive regulation of phosphatidylinositol 3 kinase signaling	GO:0014068	20	0.046	Mouse
gliogenesis	GO:0042063	141	0.046	Mouse
positive regulation of lipid biosynthetic process	GO:0046889	18	0.046	Mouse
multicellular organism growth	GO:0035264	161	0.046	Mouse
response to organonitrogen compound	GO:0010243	246	0.046
positive regulation of protein kinase activity	GO:0045860	144	0.045	Mouse
endocrine process	GO:0050886	39	0.045	Mouse
nik nf kappab signaling	GO:0038061	14	0.044	Mouse
negative regulation of carbohydrate metabolic process	GO:0045912	19	0.044	Mouse
regulation of steroid metabolic process	GO:0019218	39	0.044	Mouse
negative regulation of neuron apoptotic process	GO:0043524	92	0.043	Mouse
immune effector process	GO:0002252	321	0.042
response to lipopolysaccharide	GO:0032496	128	0.041	Rat
kidney epithelium development	GO:0072073	121	0.041	Mouse
establishment of blood nerve barrier	GO:0008065	3	0.041	Mouse
branching involved in ureteric bud morphogenesis	GO:0001658	56	0.041	Mouse
glycoprotein biosynthetic process	GO:0009101	89	0.041
positive regulation of cytokine secretion	GO:0050715	41	0.041	Mouse
mesonephros development	GO:0001823	97	0.040	Mouse
positive regulation of secretion by cell	GO:1903532	114	0.040	Mouse
neuron death	GO:0070997	154	0.039	Mouse
regulation of neuron death	GO:1901214	134	0.039	Mouse
response to decreased oxygen levels	GO:0036293	59	0.039	Rat
kidney morphogenesis	GO:0060993	83	0.039	Mouse
endothelial cell development	GO:0001885	20	0.039	Mouse
regulation of anatomical structure size	GO:0090066	178	0.039	Mouse
positive regulation of growth	GO:0045927	104	0.038	Mouse
neuron apoptotic process	GO:0051402	142	0.038	Mouse
gluconeogenesis	GO:0006094	39	0.038	Mouse
positive regulation of cytokine production	GO:0001819	174	0.037	Mouse
gonad development	GO:0008406	141	0.037	Mouse
regulation of cell activation	GO:0050865	289	0.037
regulation of cytokine secretion	GO:0050707	61	0.036	Mouse
positive regulation of blood pressure	GO:0045777	21	0.036	Mouse
feeding behavior	GO:0007631	62	0.036	Mouse
endothelial cell differentiation	GO:0045446	41	0.035	Mouse
maintenance of location	GO:0051235	89	0.035
cation homeostasis	GO:0055080	212	0.035
phasic smooth muscle contraction	GO:0014821	8	0.035	Mouse
metal ion homeostasis	GO:0055065	189	0.035
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.035	Mouse
cation transport	GO:0006812	399	0.034
regulation of systemic arterial blood pressure mediated by a chemical signal	GO:0003044	33	0.034	Mouse
regulation of systemic arterial blood pressure by renin angiotensin	GO:0003081	20	0.034	Mouse
response to metal ion	GO:0010038	47	0.034	Rat
regulation of lipid biosynthetic process	GO:0046890	54	0.034	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.033	Mouse
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	18	0.033	Mouse
vasoconstriction	GO:0042310	27	0.033	Mouse
wound healing	GO:0042060	157	0.032
ureteric bud development	GO:0001657	94	0.031	Mouse
peptidyl serine phosphorylation	GO:0018105	74	0.031	Mouse
lipid localization	GO:0010876	126	0.031
transmembrane transport	GO:0055085	412	0.031
regulation of blood vessel size by renin angiotensin	GO:0002034	5	0.031	Mouse
response to steroid hormone	GO:0048545	56	0.030	Rat
astrocyte differentiation	GO:0048708	43	0.030	Mouse
regulation of response to wounding	GO:1903034	189	0.030	Mouse
positive regulation of protein secretion	GO:0050714	52	0.029	Mouse
single organismal cell cell adhesion	GO:0016337	131	0.029
renal system process involved in regulation of systemic arterial blood pressure	GO:0003071	15	0.029	Mouse
regulation of systemic arterial blood pressure by hormone	GO:0001990	25	0.029	Mouse
blood vessel morphogenesis	GO:0048514	285	0.029
branching morphogenesis of an epithelial tube	GO:0048754	159	0.029	Mouse
cell type specific apoptotic process	GO:0097285	268	0.028	Mouse
ovulation	GO:0030728	15	0.027	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.027
cellular homeostasis	GO:0019725	240	0.026
macromolecule catabolic process	GO:0009057	281	0.026
cellular chemical homeostasis	GO:0055082	215	0.026
regulation of cellular catabolic process	GO:0031329	242	0.026
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.026	Mouse
nucleobase containing small molecule metabolic process	GO:0055086	352	0.025
aromatic compound catabolic process	GO:0019439	286	0.025
glial cell development	GO:0021782	54	0.025	Mouse
peristalsis	GO:0030432	8	0.025	Mouse
innate immune response	GO:0045087	157	0.025
regulation of cellular response to insulin stimulus	GO:1900076	30	0.025	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.024
small gtpase mediated signal transduction	GO:0007264	97	0.024
regulation of lipid metabolic process	GO:0019216	118	0.024	Mouse
nucleotide metabolic process	GO:0009117	332	0.024
organic cyclic compound catabolic process	GO:1901361	295	0.024
regulation of organ growth	GO:0046620	61	0.024	Mouse
nitrogen compound transport	GO:0071705	271	0.024
ovulation from ovarian follicle	GO:0001542	9	0.024	Mouse
regulation of nik nf kappab signaling	GO:1901222	10	0.023	Mouse
response to transition metal nanoparticle	GO:1990267	11	0.023	Rat
purine ribonucleoside metabolic process	GO:0046128	241	0.023
single organism cell adhesion	GO:0098602	156	0.023
heterocycle catabolic process	GO:0046700	280	0.023
adaptive immune response	GO:0002250	155	0.023
camera type eye development	GO:0043010	266	0.023
regulation of system process	GO:0044057	200	0.023
g protein coupled receptor signaling pathway	GO:0007186	243	0.023
response to estrogen	GO:0043627	24	0.023	Rat
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.023
negative regulation of phospholipase activity	GO:0010519	4	0.023
regulation of blood volume by renin angiotensin	GO:0002016	7	0.022	Mouse
purine nucleotide metabolic process	GO:0006163	302	0.022
phosphatidylinositol mediated signaling	GO:0048015	41	0.022	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.022
regulation of cell adhesion	GO:0030155	154	0.022
ribose phosphate metabolic process	GO:0019693	291	0.021
divalent inorganic cation homeostasis	GO:0072507	138	0.021
reactive oxygen species metabolic process	GO:0072593	84	0.021
angiogenesis	GO:0001525	201	0.021
negative regulation of cellular amine metabolic process	GO:0033239	1	0.021
sensory perception	GO:0007600	245	0.021
nucleoside phosphate catabolic process	GO:1901292	222	0.021
peripheral nervous system development	GO:0007422	53	0.021	Mouse
regulation of organelle organization	GO:0033043	289	0.021
posttranscriptional regulation of gene expression	GO:0010608	155	0.021
skeletal system development	GO:0001501	356	0.020
rho protein signal transduction	GO:0007266	32	0.020
carbohydrate derivative catabolic process	GO:1901136	231	0.020
organonitrogen compound catabolic process	GO:1901565	264	0.020
positive regulation of systemic arterial blood pressure	GO:0003084	9	0.020	Mouse
female gamete generation	GO:0007292	74	0.020	Mouse
glycosyl compound metabolic process	GO:1901657	246	0.020
positive regulation of hydrolase activity	GO:0051345	148	0.020
morphogenesis of a branching structure	GO:0001763	203	0.020	Mouse
multicellular organismal homeostasis	GO:0048871	164	0.020
striated muscle tissue development	GO:0014706	293	0.020
nucleoside triphosphate metabolic process	GO:0009141	230	0.020
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.020
sequestering of calcium ion	GO:0051208	18	0.020
gland development	GO:0048732	330	0.020
response to alcohol	GO:0097305	48	0.020	Rat
regulation of blood pressure	GO:0008217	93	0.020	Mouse
response to oxygen levels	GO:0070482	62	0.020	Rat
cellular metal ion homeostasis	GO:0006875	151	0.020
myeloid cell differentiation	GO:0030099	233	0.019
cytoplasmic transport	GO:0016482	234	0.019
positive regulation of programmed cell death	GO:0043068	218	0.019
sulfur compound metabolic process	GO:0006790	100	0.019
apoptotic signaling pathway	GO:0097190	306	0.019
muscle tissue development	GO:0060537	308	0.019
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.019
cellular ion homeostasis	GO:0006873	165	0.019
insulin receptor signaling pathway	GO:0008286	49	0.019	Mouse
muscle cell proliferation	GO:0033002	52	0.019	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.019
anatomical structure homeostasis	GO:0060249	145	0.019
amide transport	GO:0042886	138	0.018
protein catabolic process	GO:0030163	221	0.018
regulation of body fluid levels	GO:0050878	162	0.018
nucleotide catabolic process	GO:0009166	217	0.018
excretion	GO:0007588	22	0.018	Mouse
positive regulation of cell death	GO:0010942	224	0.018
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.018
ossification	GO:0001503	216	0.018
organophosphate catabolic process	GO:0046434	232	0.018
cell growth	GO:0016049	130	0.018
hematopoietic progenitor cell differentiation	GO:0002244	143	0.017
ion transmembrane transport	GO:0034220	361	0.017
epidermis development	GO:0008544	187	0.017
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.017
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.017
positive regulation of cellular response to insulin stimulus	GO:1900078	9	0.017	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.017
reactive oxygen species biosynthetic process	GO:1903409	8	0.017
ribonucleotide metabolic process	GO:0009259	291	0.017
purine nucleotide catabolic process	GO:0006195	211	0.017
purine containing compound metabolic process	GO:0072521	311	0.017
regulation of ion transport	GO:0043269	215	0.017
synaptic transmission	GO:0007268	329	0.017
response to temperature stimulus	GO:0009266	55	0.017	Mouse
regulation of vesicle mediated transport	GO:0060627	139	0.017
cellular calcium ion homeostasis	GO:0006874	119	0.017
leukocyte differentiation	GO:0002521	342	0.017
hormone secretion	GO:0046879	128	0.016
lymphocyte mediated immunity	GO:0002449	139	0.016
carbohydrate homeostasis	GO:0033500	128	0.016
purine ribonucleotide metabolic process	GO:0009150	290	0.016
purine nucleoside metabolic process	GO:0042278	241	0.016
purine ribonucleoside catabolic process	GO:0046130	205	0.016
respiratory system development	GO:0060541	190	0.016
positive regulation of mapk cascade	GO:0043410	170	0.016	Mouse
regulation of membrane potential	GO:0042391	192	0.016
glial cell differentiation	GO:0010001	131	0.016	Mouse
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.016
renal tubule morphogenesis	GO:0061333	72	0.016	Mouse
male gamete generation	GO:0048232	285	0.016	Mouse
glucose homeostasis	GO:0042593	128	0.016
positive regulation of cell development	GO:0010720	237	0.016
fat cell differentiation	GO:0045444	160	0.016
chemotaxis	GO:0006935	247	0.016
endothelium development	GO:0003158	45	0.016	Mouse
ribonucleoside metabolic process	GO:0009119	245	0.016
cellular response to cadmium ion	GO:0071276	3	0.016
ribonucleoside catabolic process	GO:0042454	206	0.016
positive regulation of organ growth	GO:0046622	29	0.016	Mouse
regulation of ras protein signal transduction	GO:0046578	114	0.016
organelle localization	GO:0051640	179	0.015
nucleoside catabolic process	GO:0009164	206	0.015
response to cold	GO:0009409	19	0.015	Mouse
cognition	GO:0050890	149	0.015
regulation of lymphocyte activation	GO:0051249	240	0.015
cellular response to dna damage stimulus	GO:0006974	207	0.015
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.015
cation transmembrane transport	GO:0098655	266	0.015
glycosyl compound catabolic process	GO:1901658	206	0.015
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.015
endocytosis	GO:0006897	168	0.015
regulation of cell motility	GO:2000145	236	0.015
ribonucleotide catabolic process	GO:0009261	208	0.015
positive regulation of immune effector process	GO:0002699	107	0.015
divalent inorganic cation transport	GO:0072511	178	0.015
regulation of vasculature development	GO:1901342	88	0.014
fat soluble vitamin biosynthetic process	GO:0042362	4	0.014
cellular macromolecule catabolic process	GO:0044265	206	0.014
transition metal ion homeostasis	GO:0055076	54	0.014
meiotic cell cycle	GO:0051321	122	0.014
nucleoside metabolic process	GO:0009116	246	0.014
calcium ion transport	GO:0006816	159	0.014
sequestering of metal ion	GO:0051238	19	0.014
cellular response to lipid	GO:0071396	145	0.014
small molecule catabolic process	GO:0044282	71	0.014
sensory organ morphogenesis	GO:0090596	242	0.014
purine nucleoside catabolic process	GO:0006152	205	0.014
cellular response to growth factor stimulus	GO:0071363	197	0.014
purine ribonucleotide catabolic process	GO:0009154	208	0.014
muscle contraction	GO:0006936	101	0.014	Mouse
regulation of cellular component biogenesis	GO:0044087	181	0.014
lymphocyte differentiation	GO:0030098	242	0.014
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.014
positive regulation of lipid metabolic process	GO:0045834	40	0.014	Mouse
membrane organization	GO:0061024	245	0.014
response to nutrient levels	GO:0031667	109	0.014
protein oligomerization	GO:0051259	67	0.014
regulation of cell cycle	GO:0051726	281	0.014
regulation of apoptotic signaling pathway	GO:2001233	197	0.013
developmental maturation	GO:0021700	193	0.013
homeostasis of number of cells	GO:0048872	210	0.013
retina development in camera type eye	GO:0060041	119	0.013
negative regulation of intracellular signal transduction	GO:1902532	167	0.013
positive regulation of cellular catabolic process	GO:0031331	148	0.013
inorganic cation transmembrane transport	GO:0098662	207	0.013
multicellular organismal signaling	GO:0035637	91	0.013
cellular lipid catabolic process	GO:0044242	52	0.013
coagulation	GO:0050817	78	0.013
cellular response to external stimulus	GO:0071496	88	0.013
intracellular protein transport	GO:0006886	204	0.013
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.013
lateral inhibition	GO:0046331	1	0.013
forebrain development	GO:0030900	302	0.013
negative regulation of immune system process	GO:0002683	209	0.013
divalent metal ion transport	GO:0070838	172	0.013
cellular protein complex assembly	GO:0043623	116	0.013
purine containing compound catabolic process	GO:0072523	213	0.013
organ regeneration	GO:0031100	2	0.013
peptide transport	GO:0015833	133	0.013
protein modification by small protein conjugation or removal	GO:0070647	207	0.013
cellular response to inorganic substance	GO:0071241	37	0.013
regulation of homeostatic process	GO:0032844	182	0.013
blood coagulation	GO:0007596	76	0.013
response to stilbenoid	GO:0035634	22	0.013
organic hydroxy compound transport	GO:0015850	93	0.013
dna metabolic process	GO:0006259	303	0.013
regulation of cellular component size	GO:0032535	121	0.013
t cell activation	GO:0042110	289	0.013
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.013
generation of precursor metabolites and energy	GO:0006091	103	0.013
regulation of interleukin 8 production	GO:0032677	3	0.013
sulfur compound biosynthetic process	GO:0044272	37	0.013
response to hypoxia	GO:0001666	58	0.013	Rat
learning or memory	GO:0007611	148	0.013
regulation of intracellular transport	GO:0032386	159	0.013
anion transport	GO:0006820	177	0.013
leukocyte mediated immunity	GO:0002443	174	0.013
regulation of action potential	GO:0098900	4	0.013
production of molecular mediator of immune response	GO:0002440	103	0.012
response to testosterone	GO:0033574	3	0.012
locomotory behavior	GO:0007626	195	0.012
positive regulation of cell adhesion	GO:0045785	80	0.012
drinking behavior	GO:0042756	5	0.012	Mouse
multi multicellular organism process	GO:0044706	109	0.012
meiotic nuclear division	GO:0007126	115	0.012
positive regulation of fatty acid oxidation	GO:0046321	4	0.012
nucleoside triphosphate catabolic process	GO:0009143	205	0.012
regulation of leukocyte mediated immunity	GO:0002703	104	0.012
cellular response to organic cyclic compound	GO:0071407	87	0.012
protein modification by small protein conjugation	GO:0032446	187	0.012
peptide secretion	GO:0002790	114	0.012
positive regulation of cell activation	GO:0050867	158	0.012
extrinsic apoptotic signaling pathway	GO:0097191	126	0.012
regulation of cell migration	GO:0030334	219	0.012
protein localization to organelle	GO:0033365	185	0.012
axonogenesis	GO:0007409	274	0.012
calcium ion homeostasis	GO:0055074	127	0.012
negative regulation of cellular component organization	GO:0051129	194	0.012
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.012
cofactor transport	GO:0051181	4	0.012
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.012
olfactory learning	GO:0008355	2	0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.012
epithelial cell proliferation	GO:0050673	174	0.012
cellular response to extracellular stimulus	GO:0031668	81	0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.012
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.012
organ growth	GO:0035265	117	0.012	Mouse
response to radiation	GO:0009314	165	0.012
positive regulation of nervous system development	GO:0051962	221	0.012
cytokine mediated signaling pathway	GO:0019221	115	0.011
negative regulation of protein modification process	GO:0031400	163	0.011
porphyrin containing compound metabolic process	GO:0006778	22	0.011
organic anion transport	GO:0015711	137	0.011
inter male aggressive behavior	GO:0002121	3	0.011
membrane lipid metabolic process	GO:0006643	53	0.011
lipid transport	GO:0006869	98	0.011
regulation of hormone secretion	GO:0046883	88	0.011
negative regulation of response to wounding	GO:1903035	77	0.011

Serpina1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
alpha 1 antitrypsin deficiency	DOID:13372	0.680	Human
plasma protein metabolism disease	DOID:2345	0.680	Human
inherited metabolic disorder	DOID:655	0.680	Human
disease of metabolism	DOID:0014667	0.680	Human
immune system disease	DOID:2914	0.059
hematopoietic system disease	DOID:74	0.059
disease of anatomical entity	DOID:7	0.059
nervous system disease	DOID:863	0.029
blood coagulation disease	DOID:1247	0.019
inherited blood coagulation disease	DOID:2214	0.018
musculoskeletal system disease	DOID:17	0.014
connective tissue disease	DOID:65	0.014
vascular disease	DOID:178	0.014
cardiovascular system disease	DOID:1287	0.014
acquired metabolic disease	DOID:0060158	0.013
primary immunodeficiency disease	DOID:612	0.012

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