IMP: Integrative Multi-species Prediction

Mus musculus

132 known processes

Dtnbp1

dystrobrevin binding protein 1

(Aliases: 5430437B18Rik,dysbindin,AW048963,sdy)

Ensembl: ENSMUSG00000057531
Entrez: 94245
UniProtKB: Q91WZ8

Process Predictions
Disease Predictions

Dtnbp1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
acetylcholine transport	GO:0015870	2	0.728
synaptic transmission	GO:0007268	329	0.411
acetate ester transport	GO:1901374	2	0.324
nitrogen compound transport	GO:0071705	271	0.149
actin cytoskeleton organization	GO:0030036	220	0.149
pigment accumulation	GO:0043476	1	0.147
neurotransmitter transport	GO:0006836	76	0.143
anterograde axon cargo transport	GO:0008089	20	0.125
muscle cell development	GO:0055001	133	0.102
microtubule based movement	GO:0007018	84	0.101
actomyosin structure organization	GO:0031032	56	0.095
pigmentation	GO:0043473	71	0.091
cellular homeostasis	GO:0019725	240	0.090
transmembrane transport	GO:0055085	412	0.089
cation transmembrane transport	GO:0098655	266	0.087
cation transport	GO:0006812	399	0.081
regulation of cellular amino acid metabolic process	GO:0006521	5	0.080
synaptic transmission cholinergic	GO:0007271	7	0.079
muscle cell differentiation	GO:0042692	261	0.079
wound healing	GO:0042060	157	0.078
cellular amine metabolic process	GO:0044106	44	0.073
purine ribonucleotide metabolic process	GO:0009150	290	0.072
vesicle organization	GO:0016050	60	0.070
cellular ketone metabolic process	GO:0042180	84	0.065
cellular component assembly involved in morphogenesis	GO:0010927	139	0.064
amine metabolic process	GO:0009308	45	0.063
nucleotide metabolic process	GO:0009117	332	0.060
anatomical structure homeostasis	GO:0060249	145	0.059
coagulation	GO:0050817	78	0.059
locomotory behavior	GO:0007626	195	0.058
regulation of lymphocyte activation	GO:0051249	240	0.058
regulation of body fluid levels	GO:0050878	162	0.058
melanosome organization	GO:0032438	8	0.055
negative regulation of molecular function	GO:0044092	258	0.052
dephosphorylation	GO:0016311	129	0.052
cellular amino acid metabolic process	GO:0006520	103	0.052
regulation of cellular ketone metabolic process	GO:0010565	66	0.051
regulation of hydrolase activity	GO:0051336	246	0.049
ion transmembrane transport	GO:0034220	361	0.048
sarcomere organization	GO:0045214	24	0.048
regulation of cellular amine metabolic process	GO:0033238	20	0.046
neuronal action potential	GO:0019228	54	0.045
purine nucleotide metabolic process	GO:0006163	302	0.044
organelle assembly	GO:0070925	177	0.043
nucleoside phosphate metabolic process	GO:0006753	338	0.042
positive regulation of cell activation	GO:0050867	158	0.041
regulation of natural killer cell activation	GO:0032814	22	0.040
nucleoside metabolic process	GO:0009116	246	0.038
hemostasis	GO:0007599	78	0.037
mitochondrion organization	GO:0007005	134	0.035
ribonucleotide metabolic process	GO:0009259	291	0.035
negative regulation of phosphorus metabolic process	GO:0010563	184	0.034
purine containing compound metabolic process	GO:0072521	311	0.033
nucleobase containing small molecule metabolic process	GO:0055086	352	0.033
negative regulation of phosphate metabolic process	GO:0045936	184	0.033
anterograde synaptic vesicle transport	GO:0048490	15	0.033
organonitrogen compound catabolic process	GO:1901565	264	0.033
oxidation reduction process	GO:0055114	342	0.033
purine nucleoside metabolic process	GO:0042278	241	0.033
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.033
microtubule based process	GO:0007017	236	0.032
positive regulation of cellular amine metabolic process	GO:0033240	5	0.032
myofibril assembly	GO:0030239	34	0.032
blood coagulation	GO:0007596	76	0.032
nucleoside catabolic process	GO:0009164	206	0.031
purine ribonucleoside metabolic process	GO:0046128	241	0.031
carbohydrate derivative catabolic process	GO:1901136	231	0.031
ribose phosphate metabolic process	GO:0019693	291	0.029
establishment of melanosome localization	GO:0032401	11	0.029
cytoplasmic transport	GO:0016482	234	0.029
membrane organization	GO:0061024	245	0.029
muscle cell cellular homeostasis	GO:0046716	12	0.029
cell adhesion	GO:0007155	329	0.028
transmission of nerve impulse	GO:0019226	76	0.028
heterocycle catabolic process	GO:0046700	280	0.027
organophosphate catabolic process	GO:0046434	232	0.027
organophosphate biosynthetic process	GO:0090407	122	0.027
regulation of organelle organization	GO:0033043	289	0.027
organelle localization	GO:0051640	179	0.027
glycerolipid metabolic process	GO:0046486	122	0.026
purine nucleotide catabolic process	GO:0006195	211	0.026
camera type eye development	GO:0043010	266	0.026
positive regulation of lymphocyte activation	GO:0051251	140	0.026
nucleotide catabolic process	GO:0009166	217	0.026
organonitrogen compound biosynthetic process	GO:1901566	192	0.026
establishment of synaptic vesicle localization	GO:0097480	57	0.026
microtubule based transport	GO:0010970	50	0.025
negative regulation of protein metabolic process	GO:0051248	282	0.025
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.025
macromolecule catabolic process	GO:0009057	281	0.025
lymphocyte differentiation	GO:0030098	242	0.025
aromatic compound catabolic process	GO:0019439	286	0.024
single organism cell adhesion	GO:0098602	156	0.024
glycosyl compound metabolic process	GO:1901657	246	0.024
positive regulation of protein modification process	GO:0031401	299	0.023
intracellular protein transport	GO:0006886	204	0.023
negative regulation of cellular component organization	GO:0051129	194	0.023
inorganic cation transmembrane transport	GO:0098662	207	0.022
glycosyl compound catabolic process	GO:1901658	206	0.022
nucleoside phosphate catabolic process	GO:1901292	222	0.022
pigment granule localization	GO:0051875	13	0.022
second messenger mediated signaling	GO:0019932	73	0.021
regulation of cell activation	GO:0050865	289	0.021
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.021
vesicle localization	GO:0051648	86	0.021
regulation of transferase activity	GO:0051338	263	0.020
striated muscle tissue development	GO:0014706	293	0.020
ensheathment of neurons	GO:0007272	76	0.020
ras protein signal transduction	GO:0007265	77	0.020
regulation of membrane potential	GO:0042391	192	0.020
small gtpase mediated signal transduction	GO:0007264	97	0.020
lytic vacuole organization	GO:0080171	21	0.020
protein targeting	GO:0006605	143	0.020
regulation of cellular component biogenesis	GO:0044087	181	0.020
chemotaxis	GO:0006935	247	0.019
hematopoietic progenitor cell differentiation	GO:0002244	143	0.019
cellular lipid metabolic process	GO:0044255	323	0.019
multicellular organismal signaling	GO:0035637	91	0.019
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.019
synaptic vesicle localization	GO:0097479	59	0.019
cellular macromolecule catabolic process	GO:0044265	206	0.019
melanocyte differentiation	GO:0030318	25	0.019
cellular protein catabolic process	GO:0044257	155	0.019
protein catabolic process	GO:0030163	221	0.019
nucleoside triphosphate metabolic process	GO:0009141	230	0.019
endocytosis	GO:0006897	168	0.019
cellular pigmentation	GO:0033059	20	0.019
modification dependent macromolecule catabolic process	GO:0043632	133	0.018
neuromuscular process	GO:0050905	99	0.018
small molecule catabolic process	GO:0044282	71	0.018
ameboidal type cell migration	GO:0001667	128	0.018
muscle system process	GO:0003012	141	0.018
protein localization to organelle	GO:0033365	185	0.018
establishment of vesicle localization	GO:0051650	81	0.018
cellular chemical homeostasis	GO:0055082	215	0.018
response to organonitrogen compound	GO:0010243	246	0.018
positive regulation of mapk cascade	GO:0043410	170	0.018
myeloid cell differentiation	GO:0030099	233	0.018
negative regulation of intracellular signal transduction	GO:1902532	167	0.018
response to inorganic substance	GO:0010035	96	0.018
muscle tissue development	GO:0060537	308	0.018
apoptotic signaling pathway	GO:0097190	306	0.018
t cell differentiation	GO:0030217	174	0.018
ribonucleotide catabolic process	GO:0009261	208	0.018
regulation of protein localization	GO:0032880	231	0.018
cellular response to arsenic containing substance	GO:0071243	4	0.018
pigment cell differentiation	GO:0050931	27	0.018
myelination	GO:0042552	74	0.018
purine nucleoside catabolic process	GO:0006152	205	0.017
t cell activation	GO:0042110	289	0.017
cytoskeleton dependent intracellular transport	GO:0030705	50	0.017
positive regulation of protein phosphorylation	GO:0001934	242	0.017
melanosome transport	GO:0032402	11	0.017
leukocyte differentiation	GO:0002521	342	0.017
purine containing compound catabolic process	GO:0072523	213	0.017
carboxylic acid catabolic process	GO:0046395	51	0.017
negative regulation of phosphorylation	GO:0042326	166	0.017
ribonucleoside metabolic process	GO:0009119	245	0.016
posttranscriptional regulation of gene expression	GO:0010608	155	0.016
peptidyl amino acid modification	GO:0018193	336	0.016
regulation of cell migration	GO:0030334	219	0.016
defense response to bacterium	GO:0042742	119	0.016
g protein coupled receptor signaling pathway	GO:0007186	243	0.016
spermatogenesis	GO:0007283	284	0.016
negative regulation of hydrolase activity	GO:0051346	71	0.016
protein maturation	GO:0051604	176	0.016
cytokine production	GO:0001816	319	0.016
negative regulation of cellular protein metabolic process	GO:0032269	247	0.016
monocarboxylic acid metabolic process	GO:0032787	191	0.015
cofactor metabolic process	GO:0051186	80	0.015
nucleoside triphosphate catabolic process	GO:0009143	205	0.015
protein targeting to vacuole	GO:0006623	3	0.015
regulation of muscle system process	GO:0090257	80	0.015
regulation of phosphoprotein phosphatase activity	GO:0043666	3	0.015
organic cyclic compound catabolic process	GO:1901361	295	0.015
phospholipid metabolic process	GO:0006644	87	0.015
lipid localization	GO:0010876	126	0.015
pigment granule transport	GO:0051904	12	0.015
lipid biosynthetic process	GO:0008610	179	0.015
epithelial cell development	GO:0002064	159	0.014
regulation of t cell activation	GO:0050863	170	0.014
cellular protein complex assembly	GO:0043623	116	0.014
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.014
developmental pigmentation	GO:0048066	40	0.014
purine ribonucleoside catabolic process	GO:0046130	205	0.014
regulation of kinase activity	GO:0043549	249	0.014
response to oxidative stress	GO:0006979	123	0.014
lipid catabolic process	GO:0016042	69	0.014
negative regulation of protein modification process	GO:0031400	163	0.014
regulation of cell motility	GO:2000145	236	0.014
protein processing	GO:0016485	163	0.014
regulation of actin filament based process	GO:0032970	99	0.014
carbohydrate derivative biosynthetic process	GO:1901137	183	0.014
sulfur compound metabolic process	GO:0006790	100	0.014
regulation of apoptotic signaling pathway	GO:2001233	197	0.013
blood vessel morphogenesis	GO:0048514	285	0.013
regulation of protein kinase activity	GO:0045859	232	0.013
single organismal cell cell adhesion	GO:0016337	131	0.013
protein modification by small protein conjugation or removal	GO:0070647	207	0.013
positive regulation of protein kinase activity	GO:0045860	144	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.013
axon cargo transport	GO:0008088	33	0.013
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.013
ribonucleoside catabolic process	GO:0042454	206	0.013
negative regulation of protein phosphorylation	GO:0001933	126	0.013
male gamete generation	GO:0048232	285	0.013
axonogenesis	GO:0007409	274	0.013
regulation of skeletal muscle adaptation	GO:0014733	12	0.013
chromatin modification	GO:0016568	187	0.013
organic hydroxy compound metabolic process	GO:1901615	203	0.013
calcium mediated signaling	GO:0019722	46	0.013
negative regulation of cellular amine metabolic process	GO:0033239	1	0.013
divalent metal ion transport	GO:0070838	172	0.013
purine containing compound biosynthetic process	GO:0072522	70	0.013
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.013
reactive oxygen species metabolic process	GO:0072593	84	0.013
cellular response to organonitrogen compound	GO:0071417	145	0.013
mapk cascade	GO:0000165	281	0.012
regulation of intracellular transport	GO:0032386	159	0.012
retina development in camera type eye	GO:0060041	119	0.012
eye pigmentation	GO:0048069	3	0.012
regulation of cell projection organization	GO:0031344	206	0.012
regulation of lipid metabolic process	GO:0019216	118	0.012
regulation of mapk cascade	GO:0043408	248	0.012
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.012
gtp catabolic process	GO:0006184	143	0.012
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway	GO:0043162	3	0.012
action potential	GO:0001508	78	0.012
axon ensheathment	GO:0008366	76	0.012
glycerophospholipid metabolic process	GO:0006650	71	0.012
meiotic nuclear division	GO:0007126	115	0.012
protein localization to membrane	GO:0072657	108	0.012
protein localization to vacuole	GO:0072665	4	0.012
purine ribonucleotide catabolic process	GO:0009154	208	0.012
lysosome organization	GO:0007040	21	0.012
secretion of lysosomal enzymes	GO:0033299	6	0.012
pigment granule organization	GO:0048753	9	0.012
positive regulation of kinase activity	GO:0033674	155	0.012
compound eye development	GO:0048749	1	0.012
carbohydrate metabolic process	GO:0005975	230	0.012
positive regulation of organelle organization	GO:0010638	128	0.012
fat cell differentiation	GO:0045444	160	0.012
establishment of protein localization to vacuole	GO:0072666	4	0.012
ubiquitin dependent protein catabolic process	GO:0006511	129	0.012
regulation of hormone levels	GO:0010817	211	0.012
striated muscle cell development	GO:0055002	125	0.012
negative regulation of organelle organization	GO:0010639	90	0.012
regulation of wnt signaling pathway	GO:0030111	123	0.012
vacuole organization	GO:0007033	38	0.012
organelle fission	GO:0048285	170	0.012
organic acid biosynthetic process	GO:0016053	86	0.012
regulation of actin cytoskeleton organization	GO:0032956	84	0.012
sequestering of calcium ion	GO:0051208	18	0.012
regulation of system process	GO:0044057	200	0.012
glycerolipid biosynthetic process	GO:0045017	50	0.012
epithelial cell proliferation	GO:0050673	174	0.011
regulation of lamellipodium assembly	GO:0010591	3	0.011
multi multicellular organism process	GO:0044706	109	0.011
regulation of nucleotide catabolic process	GO:0030811	122	0.011
wnt signaling pathway	GO:0016055	188	0.011
negative regulation of cell development	GO:0010721	169	0.011
establishment of protein localization to organelle	GO:0072594	118	0.011
developmental growth involved in morphogenesis	GO:0060560	138	0.011
response to acid chemical	GO:0001101	111	0.011
immune effector process	GO:0002252	321	0.011
homeostasis of number of cells	GO:0048872	210	0.011
substantia nigra development	GO:0021762	2	0.011
development of primary sexual characteristics	GO:0045137	143	0.011
glucose homeostasis	GO:0042593	128	0.011
ossification	GO:0001503	216	0.011
regulation of neuron differentiation	GO:0045664	281	0.011
proteasomal protein catabolic process	GO:0010498	98	0.011
positive regulation of transferase activity	GO:0051347	167	0.011
monosaccharide metabolic process	GO:0005996	106	0.011
cell growth	GO:0016049	130	0.011
positive regulation of nucleoside metabolic process	GO:0045979	91	0.011
ear development	GO:0043583	200	0.011
protein ubiquitination	GO:0016567	171	0.011
metal ion homeostasis	GO:0055065	189	0.011
chromatin organization	GO:0006325	206	0.011
regulation of purine nucleotide metabolic process	GO:1900542	169	0.011
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.011
cellular response to inorganic substance	GO:0071241	37	0.011
gtp metabolic process	GO:0046039	144	0.011
small molecule biosynthetic process	GO:0044283	132	0.011
membrane fusion	GO:0061025	38	0.011
regulation of cytokine production	GO:0001817	266	0.010
regulation of response to wounding	GO:1903034	189	0.010
meiotic cell cycle	GO:0051321	122	0.010
divalent inorganic cation transport	GO:0072511	178	0.010
glial cell differentiation	GO:0010001	131	0.010
positive regulation of programmed cell death	GO:0043068	218	0.010
positive regulation of nucleotide metabolic process	GO:0045981	114	0.010
regulation of anatomical structure size	GO:0090066	178	0.010
urogenital system development	GO:0001655	261	0.010
renal system development	GO:0072001	225	0.010
ribonucleotide biosynthetic process	GO:0009260	59	0.010
regulation of lymphocyte differentiation	GO:0045619	107	0.010
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.010
regulation of protein catabolic process	GO:0042176	108	0.010
rna interference	GO:0016246	2	0.010
nuclear transport	GO:0051169	139	0.010
modification dependent protein catabolic process	GO:0019941	133	0.010
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.010

Dtnbp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.077
nervous system disease	DOID:863	0.077
disease of metabolism	DOID:0014667	0.019
sensory system disease	DOID:0050155	0.015
organ system cancer	DOID:0050686	0.015
cancer	DOID:162	0.015
disease of cellular proliferation	DOID:14566	0.015
eye disease	DOID:5614	0.013
eye and adnexa disease	DOID:1492	0.013
inherited metabolic disorder	DOID:655	0.012

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