Mus musculus

14 known processes

Hmgcl

3-hydroxy-3-methylglutaryl-Coenzyme A lyase

(Aliases: AW476067,HL)

Hmgcl biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
oxidation reduction processGO:00551143420.205
cellular lipid metabolic processGO:00442553230.170
monocarboxylic acid metabolic processGO:00327871910.104
cellular lipid catabolic processGO:0044242520.089
cellular ketone metabolic processGO:0042180840.088
cellular amino acid metabolic processGO:00065201030.077
regulation of cellular ketone metabolic processGO:0010565660.069
carboxylic acid catabolic processGO:0046395510.065
regulation of cellular amino acid metabolic processGO:000652150.061
amine metabolic processGO:0009308450.058
cofactor metabolic processGO:0051186800.055
small molecule catabolic processGO:0044282710.050
cellular amine metabolic processGO:0044106440.046
regulation of cellular amine metabolic processGO:0033238200.041
lipid modificationGO:0030258650.039
sulfur compound metabolic processGO:00067901000.037
cation transportGO:00068123990.032
positive regulation of cellular amino acid metabolic processGO:004576430.030
lipid catabolic processGO:0016042690.030
maintenance of locationGO:0051235890.030
nitrogen compound transportGO:00717052710.030
organonitrogen compound biosynthetic processGO:19015661920.029
transmembrane transportGO:00550854120.029
small molecule biosynthetic processGO:00442831320.029
spermatogenesisGO:00072832840.029
fatty acid metabolic processGO:00066311210.029
lipid biosynthetic processGO:00086101790.029
negative regulation of cellular protein metabolic processGO:00322692470.029
inorganic ion transmembrane transportGO:00986602340.028
cation transmembrane transportGO:00986552660.028
positive regulation of cellular amine metabolic processGO:003324050.028
purine ribonucleotide metabolic processGO:00091502900.028
response to organic cyclic compoundGO:00140701980.027
regulation of hormone levelsGO:00108172110.027
male gamete generationGO:00482322850.027
macromolecule catabolic processGO:00090572810.027
nucleobase containing small molecule metabolic processGO:00550863520.027
organic hydroxy compound metabolic processGO:19016152030.027
nucleoside phosphate metabolic processGO:00067533380.026
negative regulation of cell proliferationGO:00082852960.026
cytokine productionGO:00018163190.025
ion transmembrane transportGO:00342203610.024
proteasomal protein catabolic processGO:0010498980.024
cellular amide metabolic processGO:0043603580.024
regulation of cellular catabolic processGO:00313292420.024
negative regulation of protein metabolic processGO:00512482820.024
organic acid biosynthetic processGO:0016053860.024
response to organonitrogen compoundGO:00102432460.024
carbohydrate metabolic processGO:00059752300.023
apoptotic signaling pathwayGO:00971903060.023
mapk cascadeGO:00001652810.023
regulation of mapk cascadeGO:00434082480.023
organic anion transportGO:00157111370.023
regulation of organelle organizationGO:00330432890.023
peptidyl amino acid modificationGO:00181933360.022
membrane organizationGO:00610242450.022
germ cell developmentGO:00072811850.022
immune effector processGO:00022523210.022
nucleotide metabolic processGO:00091173320.022
cellular chemical homeostasisGO:00550822150.022
purine containing compound metabolic processGO:00725213110.022
lateral inhibitionGO:004633110.021
fatty acid oxidationGO:0019395280.021
inorganic cation transmembrane transportGO:00986622070.021
regulation of secretionGO:00510462740.021
g protein coupled receptor signaling pathwayGO:00071862430.020
regulation of secretion by cellGO:19035302490.020
anion transportGO:00068201770.020
negative regulation of cellular amino acid metabolic processGO:004576300.020
organic acid catabolic processGO:0016054510.020
reactive nitrogen species metabolic processGO:200105700.020
carboxylic acid biosynthetic processGO:0046394860.020
cellular response to organonitrogen compoundGO:00714171450.020
regulation of membrane potentialGO:00423911920.019
protein processingGO:00164851630.019
protein maturationGO:00516041760.019
regulation of defense responseGO:00313472330.019
protein modification by small protein conjugationGO:00324461870.019
cellular homeostasisGO:00197252400.018
regulation of cytokine productionGO:00018172660.018
negative regulation of intracellular signal transductionGO:19025321670.018
regulation of cell cycleGO:00517262810.018
cell type specific apoptotic processGO:00972852680.018
protein ubiquitinationGO:00165671710.018
response to nutrient levelsGO:00316671090.018
response to extracellular stimulusGO:00099911270.018
negative regulation of cellular component organizationGO:00511291940.018
endomembrane system organizationGO:00102561470.018
protein catabolic processGO:00301632210.018
developmental maturationGO:00217001930.018
protein modification by small protein conjugation or removalGO:00706472070.017
reactive oxygen species metabolic processGO:0072593840.017
carbohydrate derivative biosynthetic processGO:19011371830.017
purine nucleotide metabolic processGO:00061633020.017
regulation of protein localizationGO:00328802310.017
cation homeostasisGO:00550802120.017
inflammatory responseGO:00069542440.017
sensory perceptionGO:00076002450.017
positive regulation of secretionGO:00510471300.017
lipid oxidationGO:0034440290.017
chromatin modificationGO:00165681870.017
thioester metabolic processGO:0035383190.017
microtubule based processGO:00070172360.017
ribonucleotide metabolic processGO:00092592910.017
negative regulation of phosphate metabolic processGO:00459361840.017
response to molecule of bacterial originGO:00022371430.016
cellular protein catabolic processGO:00442571550.016
multicellular organismal homeostasisGO:00488711640.016
negative regulation of cellular amine metabolic processGO:003323910.016
multicellular organismal signalingGO:0035637910.016
positive regulation of cell deathGO:00109422240.016
neuronal action potentialGO:0019228540.016
regulation of kinase activityGO:00435492490.016
positive regulation of protein modification processGO:00314012990.015
organic cyclic compound catabolic processGO:19013612950.015
nucleoside metabolic processGO:00091162460.015
regulation of apoptotic signaling pathwayGO:20012331970.015
peptide metabolic processGO:0006518460.015
regulation of cellular component biogenesisGO:00440871810.015
cellular carbohydrate metabolic processGO:00442621190.015
glycerolipid metabolic processGO:00464861220.015
cellular response to nutrient levelsGO:0031669640.015
positive regulation of protein phosphorylationGO:00019342420.015
homeostasis of number of cellsGO:00488722100.015
regulation of lymphocyte activationGO:00512492400.015
cellular macromolecule catabolic processGO:00442652060.015
action potentialGO:0001508780.015
cellular response to hormone stimulusGO:00328701500.015
regulation of reactive oxygen species metabolic processGO:2000377400.015
carbohydrate derivative catabolic processGO:19011362310.015
negative regulation of phosphorus metabolic processGO:00105631840.015
ribose phosphate metabolic processGO:00196932910.015
hematopoietic progenitor cell differentiationGO:00022441430.015
innate immune responseGO:00450871570.015
cellular ion homeostasisGO:00068731650.015
mitochondrion organizationGO:00070051340.014
regulation of transferase activityGO:00513382630.014
epithelial cell developmentGO:00020641590.014
purine ribonucleoside metabolic processGO:00461282410.014
cellular response to extracellular stimulusGO:0031668810.014
ribonucleoside metabolic processGO:00091192450.014
positive regulation of programmed cell deathGO:00430682180.014
glycosyl compound metabolic processGO:19016572460.014
endocytosisGO:00068971680.014
purine nucleoside triphosphate metabolic processGO:00091442260.014
regulation of proteolysisGO:00301621640.014
metal ion homeostasisGO:00550651890.014
t cell activationGO:00421102890.014
chromatin organizationGO:00063252060.014
cellular response to external stimulusGO:0071496880.014
regulation of protein kinase activityGO:00458592320.014
ossificationGO:00015032160.014
positive regulation of cell developmentGO:00107202370.014
response to starvationGO:0042594650.014
cellular metal ion homeostasisGO:00068751510.013
amide transportGO:00428861380.013
positive regulation of apoptotic processGO:00430652170.013
glycoprotein metabolic processGO:00091001160.013
gland developmentGO:00487323300.013
response to lipopolysaccharideGO:00324961280.013
cytoplasmic transportGO:00164822340.013
urogenital system developmentGO:00016552610.013
transmission of nerve impulseGO:0019226760.013
posttranscriptional regulation of gene expressionGO:00106081550.013
response to acid chemicalGO:00011011110.013
hexose metabolic processGO:0019318980.013
bone developmentGO:00603481200.013
skeletal system developmentGO:00015013560.013
generation of precursor metabolites and energyGO:00060911030.013
proteolysis involved in cellular protein catabolic processGO:00516031470.013
cellular nitrogen compound catabolic processGO:00442702800.013
cellular response to organic cyclic compoundGO:0071407870.013
renal system developmentGO:00720012250.013
organelle localizationGO:00516401790.013
regulation of bindingGO:00510981110.013
response to peptideGO:19016521360.013
organonitrogen compound catabolic processGO:19015652640.013
negative regulation of phosphorylationGO:00423261660.013
cellular response to starvationGO:0009267570.013
ubiquitin dependent protein catabolic processGO:00065111290.013
regulation of cell activationGO:00508652890.012
dna metabolic processGO:00062593030.012
alcohol metabolic processGO:00060661160.012
negative regulation of protein modification processGO:00314001630.012
coenzyme metabolic processGO:0006732520.012
protein oligomerizationGO:0051259670.012
carbohydrate homeostasisGO:00335001280.012
protein secretionGO:00093061110.012
very long chain fatty acid catabolic processGO:004276020.012
cellular response to lipidGO:00713961450.012
small gtpase mediated signal transductionGO:0007264970.012
extrinsic apoptotic signaling pathwayGO:00971911260.012
regulation of lipid metabolic processGO:00192161180.012
divalent metal ion transportGO:00708381720.012
synaptic transmissionGO:00072683290.012
covalent chromatin modificationGO:00165691630.012
regulation of ion transportGO:00432692150.012
divalent inorganic cation transportGO:00725111780.012
defense response to other organismGO:00985421970.012
modification dependent protein catabolic processGO:00199411330.012
negative regulation of immune system processGO:00026832090.012
reactive oxygen species biosynthetic processGO:190340980.012
calcium ion transportGO:00068161590.012
defense response to bacteriumGO:00427421190.012
negative regulation of protein phosphorylationGO:00019331260.012
regulation of protein catabolic processGO:00421761080.012
intracellular protein transportGO:00068862040.012
cell divisionGO:00513011200.012
regulation of t cell activationGO:00508631700.012
organelle fissionGO:00482851700.012
glycosyl compound catabolic processGO:19016582060.012
neuron deathGO:00709971540.012
sequestering of metal ionGO:0051238190.012
fatty acid beta oxidationGO:0006635160.012
forebrain developmentGO:00309003020.012
asymmetric stem cell divisionGO:009872230.012
erk1 and erk2 cascadeGO:0070371770.011
striated muscle tissue developmentGO:00147062930.011
modification dependent macromolecule catabolic processGO:00436321330.011
muscle tissue developmentGO:00605373080.011
circulatory system processGO:00030131970.011
aromatic compound catabolic processGO:00194392860.011
cell maturationGO:00484691270.011
divalent inorganic cation homeostasisGO:00725071380.011
positive regulation of kinase activityGO:00336741550.011
nucleotide catabolic processGO:00091662170.011
peptide transportGO:00158331330.011
purine nucleoside metabolic processGO:00422782410.011
plasma membrane organizationGO:0007009900.011
lipid localizationGO:00108761260.011
leukocyte migrationGO:00509001240.011
regulation of neuron differentiationGO:00456642810.011
nucleoside triphosphate metabolic processGO:00091412300.011
ras protein signal transductionGO:0007265770.011
peptidyl tyrosine modificationGO:00182121450.011
ribonucleoside triphosphate metabolic processGO:00091992200.011
response to peptide hormoneGO:00434341270.011
positive regulation of mapk cascadeGO:00434101700.011
histone modificationGO:00165701590.011
peptidyl tyrosine phosphorylationGO:00181081430.011
regulation of reactive oxygen species biosynthetic processGO:190342620.011
acyl coa metabolic processGO:0006637190.011
digestive system developmentGO:00551232000.011
myeloid cell differentiationGO:00300992330.010
gonad developmentGO:00084061410.010
muscle cell differentiationGO:00426922610.010
response to insulinGO:00328681000.010
positive regulation of cytokine productionGO:00018191740.010
regulation of establishment of protein localizationGO:00702011810.010
monosaccharide metabolic processGO:00059961060.010
leukocyte differentiationGO:00025213420.010
fat cell differentiationGO:00454441600.010
cell adhesionGO:00071553290.010
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.010
digestive tract developmentGO:00485651900.010
positive regulation of transferase activityGO:00513471670.010
protein localization to membraneGO:00726571080.010
purine ribonucleoside triphosphate metabolic processGO:00092052200.010
positive regulation of protein kinase activityGO:00458601440.010
development of primary male sexual characteristicsGO:0046546880.010

Hmgcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.025
inherited metabolic disorderDOID:65500.019
disease of anatomical entityDOID:700.014
nervous system diseaseDOID:86300.014
central nervous system diseaseDOID:33100.012
disease of cellular proliferationDOID:1456600.012
cancerDOID:16200.012
organ system cancerDOID:005068600.012
immune system diseaseDOID:291400.011
connective tissue diseaseDOID:6500.011
musculoskeletal system diseaseDOID:1700.011
sensory system diseaseDOID:005015500.010