Mus musculus

121 known processes

Hmgcr

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

(Aliases: HMG-CoAR,MGC103269,Red)

Hmgcr biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular alcohol biosynthetic processGO:004410830.607
lipid biosynthetic processGO:00086101790.293
cellular alcohol metabolic processGO:004410730.212
sterol metabolic processGO:0016125580.209
cellular lipid metabolic processGO:00442553230.145
steroid metabolic processGO:00082021190.128
alcohol metabolic processGO:00060661160.122
organic hydroxy compound metabolic processGO:19016152030.082
alcohol biosynthetic processGO:0046165430.066
oxidation reduction processGO:00551143420.065
regulation of cellular ketone metabolic processGO:0010565660.061
cellular amine metabolic processGO:0044106440.060
cellular amino acid metabolic processGO:00065201030.058
small molecule biosynthetic processGO:00442831320.057
cellular ketone metabolic processGO:0042180840.056
regulation of cellular amine metabolic processGO:0033238200.055
transmembrane transportGO:00550854120.053
cholesterol metabolic processGO:0008203560.053
positive regulation of cellular amino acid metabolic processGO:004576430.051
regulation of cellular amino acid metabolic processGO:000652150.049
organic hydroxy compound biosynthetic processGO:1901617770.047
negative regulation of cellular protein metabolic processGO:00322692470.046
amine metabolic processGO:0009308450.042
cholesterol biosynthetic processGO:0006695150.042
positive regulation of cellular amine metabolic processGO:003324050.041
ion transmembrane transportGO:00342203610.038
synaptic transmissionGO:00072683290.037
male gamete generationGO:00482322850.037
organonitrogen compound biosynthetic processGO:19015661920.037
anion transportGO:00068201770.037
cell adhesionGO:00071553290.036
negative regulation of molecular functionGO:00440922580.036
negative regulation of protein metabolic processGO:00512482820.034
regulation of transferase activityGO:00513382630.034
sterol biosynthetic processGO:0016126170.033
organelle assemblyGO:00709251770.032
cilium morphogenesisGO:00602711020.031
positive regulation of protein modification processGO:00314012990.031
protein catabolic processGO:00301632210.031
nitrogen compound transportGO:00717052710.030
regulation of organelle organizationGO:00330432890.030
regulation of secretionGO:00510462740.029
cellular component assembly involved in morphogenesisGO:00109271390.029
spermatogenesisGO:00072832840.029
sensory perceptionGO:00076002450.029
cellular chemical homeostasisGO:00550822150.029
lipid transportGO:0006869980.028
protein maturationGO:00516041760.028
cellular homeostasisGO:00197252400.028
monocarboxylic acid metabolic processGO:00327871910.027
regulation of protein kinase activityGO:00458592320.027
nucleobase containing small molecule metabolic processGO:00550863520.027
carbohydrate derivative biosynthetic processGO:19011371830.027
response to light stimulusGO:00094161350.027
purine ribonucleotide metabolic processGO:00091502900.027
response to organonitrogen compoundGO:00102432460.026
skin developmentGO:00435882200.026
peptidyl amino acid modificationGO:00181933360.026
microtubule based processGO:00070172360.026
t cell activationGO:00421102890.026
organic anion transportGO:00157111370.026
macromolecule catabolic processGO:00090572810.026
cation transmembrane transportGO:00986552660.025
mapk cascadeGO:00001652810.025
response to radiationGO:00093141650.025
response to peptideGO:19016521360.025
ribonucleotide metabolic processGO:00092592910.025
steroid biosynthetic processGO:0006694470.025
chemotaxisGO:00069352470.025
regulation of membrane potentialGO:00423911920.024
organic acid transportGO:00158491010.024
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.024
positive regulation of cell developmentGO:00107202370.024
neuron deathGO:00709971540.024
cellular macromolecule catabolic processGO:00442652060.024
aromatic compound catabolic processGO:00194392860.024
purine nucleotide metabolic processGO:00061633020.024
actin cytoskeleton organizationGO:00300362200.023
nucleoside phosphate metabolic processGO:00067533380.023
cell type specific apoptotic processGO:00972852680.023
cytoplasmic transportGO:00164822340.023
apoptotic signaling pathwayGO:00971903060.023
cellular nitrogen compound catabolic processGO:00442702800.023
cellular response to dna damage stimulusGO:00069742070.022
response to extracellular stimulusGO:00099911270.022
regulation of cellular component biogenesisGO:00440871810.022
negative regulation of cellular amino acid metabolic processGO:004576300.022
regulation of cell projection organizationGO:00313442060.022
nucleotide metabolic processGO:00091173320.021
inorganic ion transmembrane transportGO:00986602340.021
positive regulation of protein phosphorylationGO:00019342420.021
ribose phosphate metabolic processGO:00196932910.021
leukocyte differentiationGO:00025213420.021
regulation of secretion by cellGO:19035302490.021
digestive system developmentGO:00551232000.021
heterocycle catabolic processGO:00467002800.021
regulation of system processGO:00440572000.021
protein processingGO:00164851630.021
cation transportGO:00068123990.021
epidermis developmentGO:00085441870.021
mitochondrion organizationGO:00070051340.020
regulation of cellular catabolic processGO:00313292420.020
epithelial tube morphogenesisGO:00605623030.020
organic cyclic compound catabolic processGO:19013612950.020
regulation of lipid metabolic processGO:00192161180.020
regulation of cell adhesionGO:00301551540.020
positive regulation of programmed cell deathGO:00430682180.020
negative regulation of cellular amine metabolic processGO:003323910.020
endocytosisGO:00068971680.020
Worm
regulation of cell activationGO:00508652890.020
sensory organ morphogenesisGO:00905962420.020
axonogenesisGO:00074092740.020
carbohydrate metabolic processGO:00059752300.020
regulation of proteolysisGO:00301621640.019
cellular biogenic amine metabolic processGO:0006576280.019
ribonucleoside metabolic processGO:00091192450.019
glycerolipid metabolic processGO:00464861220.019
positive regulation of transferase activityGO:00513471670.019
regulation of ion transportGO:00432692150.019
ribonucleoside triphosphate metabolic processGO:00091992200.019
sterol transmembrane transportGO:003538220.019
carbohydrate derivative catabolic processGO:19011362310.019
cellular response to organonitrogen compoundGO:00714171450.019
inorganic cation transmembrane transportGO:00986622070.019
gland developmentGO:00487323300.019
lipid localizationGO:00108761260.019
Worm
posttranscriptional regulation of gene expressionGO:00106081550.019
ras protein signal transductionGO:0007265770.019
Fly
regulation of kinase activityGO:00435492490.019
regulation of hormone levelsGO:00108172110.018
organonitrogen compound catabolic processGO:19015652640.018
compound eye developmentGO:004874910.018
circadian rhythmGO:00076231140.018
nucleoside metabolic processGO:00091162460.018
locomotory behaviorGO:00076261950.018
Fly
purine containing compound metabolic processGO:00725213110.018
forebrain developmentGO:00309003020.018
rhodopsin mediated signaling pathwayGO:001605640.018
organophosphate catabolic processGO:00464342320.018
regulation of neuron projection developmentGO:00109751690.018
organelle fissionGO:00482851700.018
cellular response to hormone stimulusGO:00328701500.018
regulation of cellular response to stressGO:00801351590.018
membrane organizationGO:00610242450.018
nucleoside triphosphate metabolic processGO:00091412300.018
hormone secretionGO:00468791280.018
dna metabolic processGO:00062593030.018
glycosyl compound metabolic processGO:19016572460.018
epithelial cell developmentGO:00020641590.018
camera type eye developmentGO:00430102660.018
multicellular organism growthGO:00352641610.018
cilium assemblyGO:0042384810.018
maintenance of locationGO:0051235890.017
Worm
skeletal system developmentGO:00015013560.017
regulation of neuron differentiationGO:00456642810.017
regulation of apoptotic signaling pathwayGO:20012331970.017
regulation of cell cycleGO:00517262810.017
modification dependent protein catabolic processGO:00199411330.017
response to nutrient levelsGO:00316671090.017
regulation of hydrolase activityGO:00513362460.017
multicellular organismal signalingGO:0035637910.017
regulation of mapk cascadeGO:00434082480.017
regulation of homeostatic processGO:00328441820.017
purine nucleoside metabolic processGO:00422782410.017
stem cell differentiationGO:00488632680.017
sequestering of calcium ionGO:0051208180.017
response to acid chemicalGO:00011011110.017
rhythmic processGO:00485111740.017
translationGO:0006412930.017
protein ubiquitinationGO:00165671710.017
carboxylic acid transportGO:00469421000.017
regulation of neuron deathGO:19012141340.017
carbohydrate homeostasisGO:00335001280.017
peptide transportGO:00158331330.017
spermatid differentiationGO:00485151150.017
negative regulation of cellular component organizationGO:00511291940.017
nucleoside phosphate catabolic processGO:19012922220.017
protein modification by small protein conjugation or removalGO:00706472070.017
positive regulation of organelle organizationGO:00106381280.017
glucose homeostasisGO:00425931280.017
smoothened signaling pathwayGO:00072241050.017
cellular ion homeostasisGO:00068731650.017
action potentialGO:0001508780.016
myeloid cell differentiationGO:00300992330.016
homeostasis of number of cellsGO:00488722100.016
respiratory system developmentGO:00605411900.016
cellular response to cytokine stimulusGO:00713451890.016
innate immune responseGO:00450871570.016
peptidyl tyrosine phosphorylationGO:00181081430.016
negative regulation of intracellular signal transductionGO:19025321670.016
extrinsic apoptotic signaling pathwayGO:00971911260.016
modification dependent macromolecule catabolic processGO:00436321330.016
kidney developmentGO:00018222130.016
negative regulation of cell proliferationGO:00082852960.016
embryonic organ morphogenesisGO:00485622760.016
inflammatory responseGO:00069542440.016
germ cell developmentGO:00072811850.016
protein modification by small protein conjugationGO:00324461870.016
positive regulation of nervous system developmentGO:00519622210.016
lung developmentGO:00303241640.016
response to peptide hormoneGO:00434341270.016
neuronal action potentialGO:0019228540.016
sphingolipid metabolic processGO:0006665450.016
muscle cell differentiationGO:00426922610.016
striated muscle tissue developmentGO:00147062930.016
mitotic cell cycle processGO:19030471590.016
urogenital system developmentGO:00016552610.016
amide transportGO:00428861380.015
neural tube developmentGO:00219151600.015
mrna metabolic processGO:0016071840.015
positive regulation of protein kinase activityGO:00458601440.015
g protein coupled receptor signaling pathwayGO:00071862430.015
nuclear divisionGO:00002801580.015
cellular metal ion homeostasisGO:00068751510.015
positive regulation of neuron differentiationGO:00456661410.015
protein palmitoylationGO:0018345140.015
chromatin organizationGO:00063252060.015
divalent inorganic cation transportGO:00725111780.015
positive regulation of secretionGO:00510471300.015
chromatin modificationGO:00165681870.015
ribonucleoside triphosphate catabolic processGO:00092031990.015
regulation of establishment of protein localizationGO:00702011810.015
response to insulinGO:00328681000.015
ear developmentGO:00435832000.015
positive regulation of cell projection organizationGO:0031346950.015
multicellular organismal homeostasisGO:00488711640.015
peptide secretionGO:00027901140.015
anion transmembrane transportGO:0098656710.015
blood vessel morphogenesisGO:00485142850.015
glycoprotein metabolic processGO:00091001160.015
transmission of nerve impulseGO:0019226760.015
positive regulation of cell deathGO:00109422240.015
establishment or maintenance of cytoskeleton polarityGO:003095220.015
respiratory tube developmentGO:00303231670.014
male sex differentiationGO:00466611090.014
membrane lipid metabolic processGO:0006643530.014
leukocyte proliferationGO:00706611720.014
rho protein signal transductionGO:0007266320.014
fatty acid metabolic processGO:00066311210.014
spermatid developmentGO:00072861080.014
microtubule cytoskeleton organizationGO:00002261570.014
morphogenesis of a branching structureGO:00017632030.014
cellular carbohydrate metabolic processGO:00442621190.014
regulation of response to woundingGO:19030341890.014
single organism cell adhesionGO:00986021560.014
metal ion homeostasisGO:00550651890.014
embryonic epithelial tube formationGO:00018381300.014
stem cell developmentGO:00488642190.014
detection of abiotic stimulusGO:0009582600.014
regulation of t cell activationGO:00508631700.014
regulation of cell migrationGO:00303342190.014
purine containing compound catabolic processGO:00725232130.014
cell substrate adhesionGO:00315891300.014
wnt signaling pathwayGO:00160551880.014
divalent inorganic cation homeostasisGO:00725071380.014
cellular response to lipidGO:00713961450.014
organophosphate biosynthetic processGO:00904071220.014
regulation of protein processingGO:0070613960.014
purine ribonucleoside triphosphate catabolic processGO:00092071990.014
lipoprotein metabolic processGO:0042157430.014
oocyte constructionGO:000730820.014
cytokine productionGO:00018163190.014
anatomical structure homeostasisGO:00602491450.014
renal system developmentGO:00720012250.014
regulation of cell motilityGO:20001452360.014
learning or memoryGO:00076111480.014
muscle tissue developmentGO:00605373080.014
divalent metal ion transportGO:00708381720.014
placenta developmentGO:00018901400.014
telencephalon developmentGO:00215371860.014
cellular protein catabolic processGO:00442571550.014
lateral inhibitionGO:004633110.014
muscle system processGO:00030121410.014
developmental maturationGO:00217001930.014
cellular divalent inorganic cation homeostasisGO:00725031270.014
intracellular protein transportGO:00068862040.013
regulation of anatomical structure sizeGO:00900661780.013
negative regulation of protein modification processGO:00314001630.013
cell growthGO:00160491300.013
negative regulation of neuron deathGO:1901215980.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.013
purine ribonucleoside metabolic processGO:00461282410.013
neuron apoptotic processGO:00514021420.013
negative regulation of protein processingGO:0010955790.013
purine nucleoside triphosphate metabolic processGO:00091442260.013
sequestering of metal ionGO:0051238190.013
regulation of lymphocyte activationGO:00512492400.013
regulation of defense responseGO:00313472330.013
epithelial tube formationGO:00721751300.013
morphogenesis of a branching epitheliumGO:00611381930.013
macromolecule glycosylationGO:0043413550.013
negative regulation of phosphate metabolic processGO:00459361840.013
digestive tract morphogenesisGO:00485461470.013
purine ribonucleoside catabolic processGO:00461302050.013
angiogenesisGO:00015252010.013
response to organic cyclic compoundGO:00140701980.013
purine ribonucleoside triphosphate metabolic processGO:00092052200.013
demethylationGO:0070988230.013
regulation of neuron apoptotic processGO:00435231220.013
cellular protein complex assemblyGO:00436231160.013
neural tube formationGO:00018411080.013
lymphocyte proliferationGO:00466511640.013
dephosphorylationGO:00163111290.013
immune effector processGO:00022523210.013
tissue homeostasisGO:00018941150.013
digestive tract developmentGO:00485651900.013
intrinsic apoptotic signaling pathwayGO:00971931320.013
positive regulation of kinase activityGO:00336741550.013
regulation of cell morphogenesis involved in differentiationGO:00107691510.013
myosin filament assemblyGO:003103420.013
endomembrane system organizationGO:00102561470.013
monocarboxylic acid biosynthetic processGO:0072330610.013
negative regulation of neuron apoptotic processGO:0043524920.013
b cell activationGO:00421131610.013
organelle localizationGO:00516401790.013
epithelial cell proliferationGO:00506731740.012
mitotic cell cycleGO:00002781950.012
carboxylic acid biosynthetic processGO:0046394860.012
regulation of protein localizationGO:00328802310.012
peptide hormone secretionGO:00300721090.012
rna processingGO:00063961050.012
cation homeostasisGO:00550802120.012
glycosyl compound catabolic processGO:19016582060.012
fat cell differentiationGO:00454441600.012
negative regulation of phosphorus metabolic processGO:00105631840.012
blood circulationGO:00080151950.012
detection of stimulusGO:0051606840.012
morphogenesis of embryonic epitheliumGO:00163311590.012
response to growth factorGO:00708481980.012
response to oxidative stressGO:00069791230.012
extracellular structure organizationGO:00430621480.012
regulation of endopeptidase activityGO:0052548890.012
leukocyte homeostasisGO:0001776790.012
positive regulation of apoptotic signaling pathwayGO:2001235950.012
regulation of purine nucleotide metabolic processGO:19005421690.012
cellular response to peptide hormone stimulusGO:0071375920.012
skeletal muscle organ developmentGO:00605381630.012
small gtpase mediated signal transductionGO:0007264970.012
Fly
regulation of vesicle mediated transportGO:00606271390.012
regulation of reactive oxygen species metabolic processGO:2000377400.012
lymphocyte differentiationGO:00300982420.012
liver developmentGO:0001889660.012
canonical wnt signaling pathwayGO:00600701300.012
circulatory system processGO:00030131970.012
positive regulation of hydrolase activityGO:00513451480.012
hematopoietic progenitor cell differentiationGO:00022441430.012
regulation of synaptic growth at neuromuscular junctionGO:000858240.012
regulation of body fluid levelsGO:00508781620.012
ossificationGO:00015032160.012
response to monosaccharideGO:0034284670.012
cellular response to peptideGO:1901653920.012
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.012
meiotic nuclear divisionGO:00071261150.012
regionalizationGO:00030023370.012
regulation of intracellular transportGO:00323861590.012
purine ribonucleotide catabolic processGO:00091542080.012
proteasomal protein catabolic processGO:0010498980.012
heart morphogenesisGO:00030071780.012
central nervous system neuron differentiationGO:00219531620.012
dendrite developmentGO:00163581150.012
purine nucleoside catabolic processGO:00061522050.012
positive regulation of apoptotic processGO:00430652170.012
regulation of peptidase activityGO:0052547960.012
regulation of sequence specific dna binding transcription factor activityGO:00510901060.012
histone modificationGO:00165701590.012
ubiquitin dependent protein catabolic processGO:00065111290.011
myosin filament organizationGO:003103330.011
ribonucleotide catabolic processGO:00092612080.011
negative regulation of nervous system developmentGO:00519611560.011
sulfur compound metabolic processGO:00067901000.011
purine nucleoside triphosphate catabolic processGO:00091462030.011
regulation of nucleotide metabolic processGO:00061401690.011
positive regulation of cell activationGO:00508671580.011
phospholipid metabolic processGO:0006644870.011
regulation of protein catabolic processGO:00421761080.011
regulation of leukocyte proliferationGO:00706631210.011
regulation of hormone secretionGO:0046883880.011
response to inorganic substanceGO:0010035960.011
amino acid transportGO:0006865610.011
covalent chromatin modificationGO:00165691630.011
positive regulation of cellular catabolic processGO:00313311480.011
regulation of cytokine productionGO:00018172660.011
defense response to bacteriumGO:00427421190.011
developmental growth involved in morphogenesisGO:00605601380.011
purine nucleotide catabolic processGO:00061952110.011
regulation of cytoskeleton organizationGO:00514931220.011
cellular response to external stimulusGO:0071496880.011
organic hydroxy compound transportGO:0015850930.011
regulation of protein transportGO:00512231630.011
cellular response to nutrient levelsGO:0031669640.011
positive regulation of purine nucleotide metabolic processGO:19005441140.011
regulation of translationGO:0006417710.011
nucleoside triphosphate catabolic processGO:00091432050.011
positive regulation of growthGO:00459271040.011
dna repairGO:00062811070.011
calcium ion homeostasisGO:00550741270.011
negative regulation of apoptotic signaling pathwayGO:20012341040.011
cognitionGO:00508901490.011
negative regulation of protein maturationGO:1903318790.011
glycerophospholipid metabolic processGO:0006650710.011
methylationGO:00322591340.011
regulation of wnt signaling pathwayGO:00301111230.011
ameboidal type cell migrationGO:00016671280.011
intracellular mrna localizationGO:000829840.011
insulin secretionGO:0030073890.011
cellular response to extracellular stimulusGO:0031668810.011
peptidyl tyrosine modificationGO:00182121450.011
positive regulation of lymphocyte activationGO:00512511400.011
positive regulation of cytokine productionGO:00018191740.011
cell activation involved in immune responseGO:00022631260.011
sensory perception of mechanical stimulusGO:00509541070.011
negative regulation of proteolysisGO:0045861740.011
nuclear transportGO:00511691390.011
carbohydrate transportGO:0008643620.011
oocyte axis specificationGO:000730920.011
regulation of protein serine threonine kinase activityGO:00719001570.011
cell matrix adhesionGO:0007160680.011
regulation of lymphocyte proliferationGO:00506701170.011
cytokine mediated signaling pathwayGO:00192211150.011
negative regulation of immune system processGO:00026832090.011
establishment of blood nerve barrierGO:000806530.011
gliogenesisGO:00420631410.011
asymmetric stem cell divisionGO:009872230.011
regulation of metal ion transportGO:00109591060.011
positive regulation of mapk cascadeGO:00434101700.011
Fly
meiotic cell cycleGO:00513211220.011
tube formationGO:00351481400.011
negative regulation of phosphorylationGO:00423261660.010
negative regulation of organelle organizationGO:0010639900.010
organic acid biosynthetic processGO:0016053860.010
cellularizationGO:000734910.010
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.010
embryonic placenta developmentGO:0001892980.010
negative regulation of cell developmentGO:00107211690.010
macromolecule methylationGO:00434141200.010
t cell proliferationGO:00420981200.010
regulation of ion transmembrane transportGO:00347651190.010
myeloid leukocyte differentiationGO:00025731190.010
glycoprotein biosynthetic processGO:0009101890.010
lymphocyte activation involved in immune responseGO:0002285930.010
regulation of transmembrane transportGO:00347621280.010
isoprenoid metabolic processGO:0006720290.010
maternal determination of anterior posterior axis embryoGO:000835820.010
neuron projection guidanceGO:00974851410.010
positive regulation of neuron projection developmentGO:0010976790.010
cellular calcium ion homeostasisGO:00068741190.010
muscle contractionGO:00069361010.010
neural precursor cell proliferationGO:00613511210.010
lymphocyte mediated immunityGO:00024491390.010
sterol transportGO:0015918380.010
glycerolipid biosynthetic processGO:0045017500.010
calcium ion transportGO:00068161590.010
limb developmentGO:00601731660.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.010
protein glycosylationGO:0006486550.010
regulation of reactive oxygen species biosynthetic processGO:190342620.010
protein targetingGO:00066051430.010
wound healingGO:00420601570.010
actin filament organizationGO:00070151130.010

Hmgcr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.026
nervous system diseaseDOID:86300.026
disease of metabolismDOID:001466700.024
inherited metabolic disorderDOID:65500.024
disease of cellular proliferationDOID:1456600.021
organ system cancerDOID:005068600.017
cancerDOID:16200.017
central nervous system diseaseDOID:33100.016
immune system diseaseDOID:291400.010