Mus musculus

53 known processes

Melk

maternal embryonic leucine zipper kinase

(Aliases: AI327312,MPK38,mKIAA0175)

Melk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nuclear divisionGO:00002801580.627
dna metabolic processGO:00062593030.552
chromosome segregationGO:0007059480.545
organelle fissionGO:00482851700.494
modification dependent protein catabolic processGO:00199411330.391
sister chromatid segregationGO:0000819200.388
ubiquitin dependent protein catabolic processGO:00065111290.319
dna replicationGO:0006260520.317
cellular protein catabolic processGO:00442571550.308
regulation of cell cycleGO:00517262810.291
meiotic nuclear divisionGO:00071261150.273
regulation of chromosome segregationGO:0051983210.247
cellular response to dna damage stimulusGO:00069742070.241
mitotic cell cycle processGO:19030471590.240
regulation of mitotic cell cycle phase transitionGO:1901990730.229
regulation of cellular protein catabolic processGO:1903362610.213
cellular macromolecule catabolic processGO:00442652060.206
mitotic nuclear divisionGO:0007067480.204
meiotic cell cycleGO:00513211220.196
microtubule based processGO:00070172360.193
regulation of cell cycle processGO:00105641600.183
dna endoreduplicationGO:004202340.175
mitotic cell cycleGO:00002781950.169
positive regulation of chromosome segregationGO:005198440.167
regulation of organelle organizationGO:00330432890.156
regulation of cellular catabolic processGO:00313292420.154
Mouse
mitotic sister chromatid segregationGO:0000070140.152
double strand break repairGO:0006302480.150
regulation of cell cycle phase transitionGO:1901987770.141
macromolecule catabolic processGO:00090572810.136
regulation of protein kinase activityGO:00458592320.128
meiosis iGO:0007127600.126
dna repairGO:00062811070.126
regulation of cellular ketone metabolic processGO:0010565660.124
regulation of exit from mitosisGO:000709610.120
microtubule cytoskeleton organizationGO:00002261570.116
regulation of chromosome organizationGO:0033044830.110
positive regulation of cell cycleGO:0045787920.110
germ cell developmentGO:00072811850.105
positive regulation of protein phosphorylationGO:00019342420.100
mitotic sister chromatid cohesionGO:000706410.099
purine nucleotide metabolic processGO:00061633020.099
intrinsic apoptotic signaling pathwayGO:00971931320.098
chromosome separationGO:0051304140.098
positive regulation of mitotic sister chromatid separationGO:190197020.091
regulation of proteasomal protein catabolic processGO:0061136460.091
regulation of protein localizationGO:00328802310.091
mitotic sister chromatid separationGO:005130690.090
response to organic cyclic compoundGO:00140701980.090
Mouse
nucleoside phosphate metabolic processGO:00067533380.089
meiotic cell cycle processGO:1903046770.082
regulation of cell divisionGO:0051302760.079
organonitrogen compound catabolic processGO:19015652640.076
metaphase anaphase transition of mitotic cell cycleGO:000709190.075
negative regulation of mitotic cell cycle phase transitionGO:1901991450.074
regulation of metaphase anaphase transition of cell cycleGO:190209990.071
proteolysis involved in cellular protein catabolic processGO:00516031470.070
negative regulation of cellular protein metabolic processGO:00322692470.070
regulation of proteolysisGO:00301621640.068
negative regulation of cellular component organizationGO:00511291940.067
protein catabolic processGO:00301632210.065
positive regulation of protein modification processGO:00314012990.065
cell divisionGO:00513011200.065
Worm
ribonucleoside catabolic processGO:00424542060.065
cellular amino acid metabolic processGO:00065201030.064
proteasomal protein catabolic processGO:0010498980.064
organic cyclic compound catabolic processGO:19013612950.062
ribose phosphate metabolic processGO:00196932910.060
purine containing compound metabolic processGO:00725213110.060
positive regulation of cellular catabolic processGO:00313311480.060
Mouse
chromatin organizationGO:00063252060.060
Mouse
glycosyl compound catabolic processGO:19016582060.059
nucleotide metabolic processGO:00091173320.059
male gamete generationGO:00482322850.058
purine ribonucleotide metabolic processGO:00091502900.057
regulation of mitotic sister chromatid segregationGO:0033047120.056
negative regulation of mitosisGO:0045839100.056
microtubule cytoskeleton organization involved in mitosisGO:190285040.055
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434400.055
cleavage furrow formationGO:003608920.054
synapsisGO:0007129340.052
regulation of transferase activityGO:00513382630.051
nucleoside phosphate catabolic processGO:19012922220.051
nucleobase containing small molecule metabolic processGO:00550863520.050
cell fate commitmentGO:00451652100.049
Worm
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.048
purine ribonucleoside monophosphate catabolic processGO:0009169570.048
negative regulation of transcription involved in g1 s transition of mitotic cell cycleGO:007193010.047
mitotic cytokinesisGO:000028140.047
organelle assemblyGO:00709251770.046
spindle assembly involved in mitosisGO:009030740.046
covalent chromatin modificationGO:00165691630.046
Mouse
protein ubiquitinationGO:00165671710.045
establishment of organelle localizationGO:00516561220.045
modification dependent macromolecule catabolic processGO:00436321330.044
positive regulation of apoptotic processGO:00430652170.044
regulation of attachment of spindle microtubules to kinetochoreGO:005198830.043
purine ribonucleoside triphosphate metabolic processGO:00092052200.043
organelle localizationGO:00516401790.043
ribonucleotide metabolic processGO:00092592910.043
response to radiationGO:00093141650.043
Mouse
purine nucleoside metabolic processGO:00422782410.043
cell cycle g1 s phase transitionGO:0044843570.043
regulation of protein catabolic processGO:00421761080.042
translesion synthesisGO:001998510.042
nucleoside triphosphate metabolic processGO:00091412300.042
nucleoside catabolic processGO:00091642060.041
cellular amine metabolic processGO:0044106440.041
purine ribonucleoside metabolic processGO:00461282410.041
positive regulation of hydrolase activityGO:00513451480.041
maintenance of locationGO:0051235890.041
nucleoside metabolic processGO:00091162460.041
cellular response to growth factor stimulusGO:00713631970.040
positive regulation of cell deathGO:00109422240.039
regulation of mitotic cell cycleGO:00073461260.039
attachment of spindle microtubules to kinetochoreGO:000860840.039
response to organonitrogen compoundGO:00102432460.039
Mouse
dna recombinationGO:0006310920.038
chromatin modificationGO:00165681870.038
Mouse
nucleoside triphosphate catabolic processGO:00091432050.038
cytokinesisGO:0000910170.038
ribonucleoside metabolic processGO:00091192450.038
negative regulation of cellular protein catabolic processGO:1903363220.038
cytokinetic processGO:003250620.037
heterocycle catabolic processGO:00467002800.037
regulation of microtubule cytoskeleton organizationGO:0070507370.037
histone threonine phosphorylationGO:003540510.036
negative regulation of phosphorus metabolic processGO:00105631840.036
negative regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032435150.036
protein processingGO:00164851630.036
dna dependent dna replicationGO:0006261240.035
negative regulation of protein metabolic processGO:00512482820.035
placenta developmentGO:00018901400.035
purine nucleoside triphosphate catabolic processGO:00091462030.035
cell type specific apoptotic processGO:00972852680.035
positive regulation of organelle organizationGO:00106381280.034
protein localization to organelleGO:00333651850.034
protein modification by small protein conjugation or removalGO:00706472070.033
regulation of nuclear divisionGO:0051783560.033
positive regulation of cell divisionGO:0051781310.033
negative regulation of proteolysisGO:0045861740.033
female gamete generationGO:0007292740.033
regulation of cellular amine metabolic processGO:0033238200.032
regulation of cellular amino acid metabolic processGO:000652150.032
regulation of protein maturationGO:1903317960.032
regulation of mitotic sister chromatid separationGO:0010965120.032
nucleoside monophosphate metabolic processGO:0009123850.032
cell cycle g2 m phase transitionGO:0044839200.032
meiosis iiGO:000713570.032
synaptonemal complex assemblyGO:0007130130.031
regulation of kinase activityGO:00435492490.031
lateral inhibitionGO:004633110.031
male meiosisGO:0007140370.031
regulation of nucleocytoplasmic transportGO:0046822730.031
positive regulation of metaphase anaphase transition of cell cycleGO:190210120.031
carbohydrate derivative catabolic processGO:19011362310.031
cellular homeostasisGO:00197252400.031
negative regulation of protein maturationGO:1903318790.031
negative regulation of mitotic cell cycleGO:0045930580.031
regulation of sister chromatid segregationGO:0033045130.030
sister chromatid cohesionGO:0007062120.030
negative regulation of cell cycleGO:00457861230.029
nucleotide catabolic processGO:00091662170.029
negative regulation of sister chromatid segregationGO:003304670.029
positive regulation of kinase activityGO:00336741550.029
apoptotic signaling pathwayGO:00971903060.029
positive regulation of protein kinase activityGO:00458601440.028
glycosyl compound metabolic processGO:19016572460.028
peptidyl serine phosphorylationGO:0018105740.027
Mouse
female meiotic divisionGO:0007143210.027
purine nucleotide catabolic processGO:00061952110.027
positive regulation of programmed cell deathGO:00430682180.027
nucleoside monophosphate catabolic processGO:0009125590.027
female meiosis chromosome segregationGO:001632110.027
purine ribonucleoside catabolic processGO:00461302050.027
gland developmentGO:00487323300.027
regulation of hydrolase activityGO:00513362460.026
purine nucleoside catabolic processGO:00061522050.026
wnt signaling pathwayGO:00160551880.026
purine nucleoside triphosphate metabolic processGO:00091442260.026
regulation of mitotic metaphase anaphase transitionGO:003007180.026
oogenesisGO:0048477560.026
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051220.026
purine containing compound catabolic processGO:00725232130.026
cellular response to lipidGO:00713961450.025
cellular ketone metabolic processGO:0042180840.025
embryonic epithelial tube formationGO:00018381300.025
cell adhesionGO:00071553290.025
regulation of mitosisGO:0007088290.025
spindle checkpointGO:0031577120.025
amine metabolic processGO:0009308450.025
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.025
mitotic spindle checkpointGO:007117490.025
positive regulation of cellular amino acid metabolic processGO:004576430.025
synaptonemal complex organizationGO:0070193150.025
aromatic compound catabolic processGO:00194392860.024
regulation of cell sizeGO:0008361720.024
cellular nitrogen compound catabolic processGO:00442702800.024
positive regulation of exit from mitosisGO:003153610.024
response to acid chemicalGO:00011011110.024
positive regulation of cellular amine metabolic processGO:003324050.024
endocytosisGO:00068971680.024
regulation of protein processingGO:0070613960.023
regulation of cytoplasmic transportGO:19036491120.023
positive regulation of meiotic cell cycleGO:0051446150.023
mapk cascadeGO:00001652810.023
regulation of response to woundingGO:19030341890.023
negative regulation of cellular catabolic processGO:0031330470.023
leukocyte homeostasisGO:0001776790.023
regulation of protein serine threonine kinase activityGO:00719001570.023
muscle cell differentiationGO:00426922610.023
peptidyl amino acid modificationGO:00181933360.023
Human Mouse
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic processGO:003114590.023
microtubule anchoringGO:003445390.023
g1 s transition of mitotic cell cycleGO:0000082570.022
oocyte differentiationGO:0009994350.022
germline cell cycle switching mitotic to meiotic cell cycleGO:005172910.022
positive regulation of proteolysisGO:0045862850.022
cellular lipid metabolic processGO:00442553230.022
Mouse
ribonucleoside monophosphate metabolic processGO:0009161800.022
regulation of cellular response to stressGO:00801351590.022
cellularizationGO:000734910.021
histone modificationGO:00165701590.021
Mouse
positive regulation of mitotic cell cycle phase transitionGO:1901992170.021
negative regulation of protein processingGO:0010955790.021
protein maturationGO:00516041760.021
regulation of cell projection organizationGO:00313442060.021
negative regulation of molecular functionGO:00440922580.021
oocyte maturationGO:0001556180.021
intracellular mrna localizationGO:000829840.020
positive regulation of mitotic metaphase anaphase transitionGO:004584220.020
organophosphate catabolic processGO:00464342320.020
mitotic spindle organizationGO:0007052100.020
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079160.020
ribonucleoside monophosphate catabolic processGO:0009158570.020
muscle cell developmentGO:00550011330.020
regulation of defense responseGO:00313472330.019
purine nucleoside monophosphate catabolic processGO:0009128580.019
purine ribonucleoside triphosphate catabolic processGO:00092071990.019
regulation of double strand break repair via homologous recombinationGO:001056920.019
negative regulation of protein dephosphorylationGO:003530820.019
response to oxidative stressGO:00069791230.019
ribonucleoside triphosphate catabolic processGO:00092031990.019
negative regulation of protein modification processGO:00314001630.019
response to inorganic substanceGO:0010035960.019
Mouse
regulation of intracellular transportGO:00323861590.019
mitotic spindle assembly checkpointGO:000709470.019
organism emergence from protective structureGO:007168440.019
negative regulation of protein phosphorylationGO:00019331260.019
protein modification by small protein conjugationGO:00324461870.019
negative regulation of cell cycle phase transitionGO:1901988480.018
histone serine phosphorylationGO:003540450.018
Mouse
response to metal ionGO:0010038470.018
purine nucleoside monophosphate metabolic processGO:0009126810.018
positive regulation of mitotic cell cycleGO:0045931410.018
negative regulation of organelle organizationGO:0010639900.018
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.018
muscle tissue developmentGO:00605373080.017
spindle assembly involved in meiosisGO:009030640.017
positive regulation of protein serine threonine kinase activityGO:00719021060.017
mrna metabolic processGO:0016071840.017
positive regulation of nuclear divisionGO:0051785270.017
negative regulation of cell cycle processGO:0010948690.017
digestive tract developmentGO:00485651900.017
oxidation reduction processGO:00551143420.017
Mouse
metaphase plate congressionGO:005131020.017
regulation of establishment of protein localizationGO:00702011810.017
ras protein signal transductionGO:0007265770.017
dephosphorylationGO:00163111290.017
negative regulation of nuclear divisionGO:0051784190.016
spindle assembly involved in female meiosisGO:000705630.016
negative regulation of cell proliferationGO:00082852960.016
purine ribonucleotide catabolic processGO:00091542080.016
rho protein signal transductionGO:0007266320.016
actomyosin structure organizationGO:0031032560.016
atp metabolic processGO:0046034750.016
protein localization to chromosomeGO:003450260.016
regulation of neuron deathGO:19012141340.016
positive regulation of transferase activityGO:00513471670.016
positive regulation of cell developmentGO:00107202370.015
cell maturationGO:00484691270.015
negative regulation of phosphorylationGO:00423261660.015
regulation of protein transportGO:00512231630.015
ribonucleotide catabolic processGO:00092612080.015
regulation of lymphocyte activationGO:00512492400.015
regulation of ras protein signal transductionGO:00465781140.015
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.015
dna replication independent nucleosome assemblyGO:000633610.015
regulation of chromatin modificationGO:1903308570.015
regulation of homeostatic processGO:00328441820.015
inflammatory responseGO:00069542440.015
spermatogenesisGO:00072832840.015
cellular response to organic cyclic compoundGO:0071407870.015
positive regulation of chromosome organizationGO:2001252330.015
folic acid containing compound metabolic processGO:000676030.015
dna conformation changeGO:0071103370.015
positive regulation of nervous system developmentGO:00519622210.015
regulation of inflammatory responseGO:00507271470.015
posttranscriptional regulation of gene expressionGO:00106081550.014
regulation of meiotic cell cycleGO:0051445340.014
purine ribonucleoside monophosphate metabolic processGO:0009167800.014
negative regulation of phosphate metabolic processGO:00459361840.014
membrane organizationGO:00610242450.014
positive regulation of protein catabolic processGO:0045732600.014
response to decreased oxygen levelsGO:0036293590.014
citrate metabolic processGO:000610130.014
regulation of sister chromatid cohesionGO:000706350.014
carbohydrate homeostasisGO:00335001280.014
Mouse
regulation of secretionGO:00510462740.014
neural tube developmentGO:00219151600.014
neuron apoptotic processGO:00514021420.014
positive regulation of intracellular transportGO:0032388700.014
negative regulation of protein catabolic processGO:0042177360.014
developmental maturationGO:00217001930.013
cellular response to radiationGO:0071478280.013
mitotic chromosome condensationGO:000707610.013
asymmetric stem cell divisionGO:009872230.013
Worm
nucleotide biosynthetic processGO:0009165780.013
myosin filament assemblyGO:003103420.013
positive regulation of purine nucleotide metabolic processGO:19005441140.013
epithelial tube morphogenesisGO:00605623030.013
dna packagingGO:0006323300.013
neuron deathGO:00709971540.013
spindle midzone assemblyGO:005125510.013
striated muscle tissue developmentGO:00147062930.012
regulation of apoptotic signaling pathwayGO:20012331970.012
monocarboxylic acid metabolic processGO:00327871910.012
Mouse
spindle organizationGO:0007051280.012
centromere complex assemblyGO:003450830.012
positive regulation of mitosisGO:0045840140.012
regulation of secretion by cellGO:19035302490.012
epithelial tube formationGO:00721751300.012
response to ionizing radiationGO:0010212420.012
Mouse
liver developmentGO:0001889660.012
digestive system developmentGO:00551232000.012
regulation of neuron differentiationGO:00456642810.012
ribonucleoside triphosphate metabolic processGO:00091992200.012
cervix developmentGO:006006720.012
regulation of neuron projection developmentGO:00109751690.012
meiotic cytokinesisGO:003320650.012
negative regulation of mitotic sister chromatid segregationGO:003304870.012
regulation of cell activationGO:00508652890.011
regulation of intracellular protein transportGO:0033157820.011
negative regulation of mitotic metaphase anaphase transitionGO:004584170.011
t cell activationGO:00421102890.011
protein localization to chromosome centromeric regionGO:007145910.011
endomembrane system organizationGO:00102561470.011
meiotic dna repair synthesisGO:000071140.011
regulation of t cell activationGO:00508631700.011
regulation of protein modification by small protein conjugation or removalGO:1903320570.011
regulation of bindingGO:00510981110.011
response to molecule of bacterial originGO:00022371430.011
dna ligationGO:000626630.011
organophosphate biosynthetic processGO:00904071220.011
positive regulation of cell cycle processGO:0090068610.011
regulation of mapk cascadeGO:00434082480.011
regulation of protein targetingGO:1903533610.011
response to growth factorGO:00708481980.011
glucose homeostasisGO:00425931280.011
Mouse
nitrogen compound transportGO:00717052710.011
cytoplasmic transportGO:00164822340.011
anatomical structure homeostasisGO:00602491450.011
negative regulation of metaphase anaphase transition of cell cycleGO:190210080.011
cellular response to abiotic stimulusGO:0071214560.011
neural tube formationGO:00018411080.011
gastrulationGO:00073691160.011
cell cycle comprising mitosis without cytokinesisGO:003330110.011
fibroblast proliferationGO:0048144350.011
response to reactive oxygen speciesGO:0000302560.011
Mouse
tube closureGO:0060606910.010
mrna processingGO:0006397630.010
genitalia developmentGO:0048806370.010
lymphocyte mediated immunityGO:00024491390.010
fibroblast growth factor receptor signaling pathwayGO:0008543460.010
immune effector processGO:00022523210.010
regulation of purine nucleotide metabolic processGO:19005421690.010
rna processingGO:00063961050.010
positive regulation of proteolysis involved in cellular protein catabolic processGO:1903052310.010
meiotic chromosome segregationGO:0045132190.010

Melk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.101
cancerDOID:16200.051
organ system cancerDOID:005068600.044
thoracic cancerDOID:509300.033
breast cancerDOID:161200.026
inherited metabolic disorderDOID:65500.018
disease of metabolismDOID:001466700.018