IMP: Integrative Multi-species Prediction

Mus musculus

14 known processes

Wisp2

WNT1 inducible signaling pathway protein 2

(Aliases: Ccn5,Ctgfl,Rcop1,Crgr4)

Ensembl: ENSMUSG00000027656
Entrez: 22403
UniProtKB: A2AHD1
UniProtKB: Q9Z0G4

Process Predictions
Disease Predictions

Wisp2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
angiogenesis	GO:0001525	201	0.631	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.488	Mouse
regulation of response to wounding	GO:1903034	189	0.433
regulation of cell motility	GO:2000145	236	0.411	Mouse
regulation of defense response	GO:0031347	233	0.403
extrinsic apoptotic signaling pathway	GO:0097191	126	0.314
inflammatory response	GO:0006954	244	0.300
blood vessel morphogenesis	GO:0048514	285	0.294	Mouse
signal transduction in absence of ligand	GO:0038034	55	0.283
cellular response to growth factor stimulus	GO:0071363	197	0.282	Mouse
calcium ion homeostasis	GO:0055074	127	0.273
regulation of inflammatory response	GO:0050727	147	0.269
cytokine production	GO:0001816	319	0.230
t cell differentiation	GO:0030217	174	0.218
chemotaxis	GO:0006935	247	0.216
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.212
leukocyte migration	GO:0050900	124	0.206
striated muscle cell development	GO:0055002	125	0.204
response to growth factor	GO:0070848	198	0.204	Mouse
sensory perception of mechanical stimulus	GO:0050954	107	0.201
response to hypoxia	GO:0001666	58	0.200
positive regulation of cellular amine metabolic process	GO:0033240	5	0.199
cytokine secretion	GO:0050663	72	0.197
t cell activation	GO:0042110	289	0.193
positive regulation of cell migration	GO:0030335	109	0.189	Mouse
morphogenesis of a branching structure	GO:0001763	203	0.188
regulation of cellular ketone metabolic process	GO:0010565	66	0.186
cell chemotaxis	GO:0060326	81	0.186
regulation of monocyte chemotaxis	GO:0090025	3	0.184
response to molecule of bacterial origin	GO:0002237	143	0.175
positive regulation of protein modification process	GO:0031401	299	0.174
morphogenesis of a branching epithelium	GO:0061138	193	0.167
positive regulation of monocyte chemotaxis	GO:0090026	2	0.160
positive regulation of programmed cell death	GO:0043068	218	0.159	Mouse
regulation of cytokine production	GO:0001817	266	0.158
lung development	GO:0030324	164	0.156	Mouse
regulation of angiogenesis	GO:0045765	81	0.153
epithelial cell proliferation	GO:0050673	174	0.148
cellular response to cytokine stimulus	GO:0071345	189	0.147
metal ion homeostasis	GO:0055065	189	0.146
leukocyte apoptotic process	GO:0071887	71	0.145
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.144
apoptotic signaling pathway	GO:0097190	306	0.142
protein secretion	GO:0009306	111	0.138
extracellular matrix organization	GO:0030198	147	0.137	Mouse
positive regulation of defense response	GO:0031349	124	0.131
regulation of leukocyte proliferation	GO:0070663	121	0.130
striated muscle tissue development	GO:0014706	293	0.127
divalent metal ion transport	GO:0070838	172	0.126
b cell activation	GO:0042113	161	0.125
regulation of cell substrate adhesion	GO:0010810	73	0.125	Mouse
release of sequestered calcium ion into cytosol	GO:0051209	42	0.123
regulation of vasculature development	GO:1901342	88	0.122
positive regulation of transferase activity	GO:0051347	167	0.121
regulation of homeostatic process	GO:0032844	182	0.119
negative regulation of angiogenesis	GO:0016525	25	0.116
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.116
positive regulation of cell activation	GO:0050867	158	0.115
axon guidance	GO:0007411	141	0.115
interleukin 1 secretion	GO:0050701	16	0.114
positive regulation of protein phosphorylation	GO:0001934	242	0.114
cell type specific apoptotic process	GO:0097285	268	0.111
smoothened signaling pathway	GO:0007224	105	0.111
innate immune response	GO:0045087	157	0.109
sequestering of metal ion	GO:0051238	19	0.107
positive regulation of nervous system development	GO:0051962	221	0.107
regulation of calcium ion transport	GO:0051924	69	0.104
regulation of secretion by cell	GO:1903530	249	0.104
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.104
regulation of cell activation	GO:0050865	289	0.103
positive regulation of t cell costimulation	GO:2000525	2	0.103
positive regulation of cytokine production	GO:0001819	174	0.102
positive regulation of chemotaxis	GO:0050921	38	0.101
helper t cell chemotaxis	GO:0035704	1	0.101
calcium ion transport	GO:0006816	159	0.100
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.100
cellular response to oxidative stress	GO:0034599	76	0.100
neuron projection guidance	GO:0097485	141	0.099
regulation of apoptotic signaling pathway	GO:2001233	197	0.099
positive regulation of cell motility	GO:2000147	116	0.098	Mouse
cellular response to amino acid stimulus	GO:0071230	29	0.098
myeloid leukocyte activation	GO:0002274	83	0.097
muscle cell development	GO:0055001	133	0.096
muscle cell differentiation	GO:0042692	261	0.095
wound healing	GO:0042060	157	0.094
positive regulation of monocyte extravasation	GO:2000439	1	0.094
regulation of cytokine secretion	GO:0050707	61	0.094
t cell proliferation	GO:0042098	120	0.093
t cell extravasation	GO:0072683	4	0.092
mapk cascade	GO:0000165	281	0.091
regulation of chemotaxis	GO:0050920	53	0.090
positive regulation of inflammatory response	GO:0050729	47	0.090
positive regulation of secretion	GO:0051047	130	0.089
response to organonitrogen compound	GO:0010243	246	0.088
cell fate commitment	GO:0045165	210	0.088
tissue remodeling	GO:0048771	102	0.087
cell substrate adhesion	GO:0031589	130	0.087	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.087
muscle system process	GO:0003012	141	0.087
regulation of adaptive immune response	GO:0002819	90	0.086
cellular response to acid chemical	GO:0071229	68	0.085
positive regulation of dendritic cell chemotaxis	GO:2000510	1	0.085
divalent inorganic cation transport	GO:0072511	178	0.084
regulation of b cell proliferation	GO:0030888	39	0.083
leukocyte differentiation	GO:0002521	342	0.081
regulation of protein kinase activity	GO:0045859	232	0.080
granulocyte migration	GO:0097530	43	0.079
fat cell differentiation	GO:0045444	160	0.078
regulation of secretion	GO:0051046	274	0.078
urogenital system development	GO:0001655	261	0.077
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.077	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.077	Mouse
regulation of lymphocyte proliferation	GO:0050670	117	0.077
defense response to bacterium	GO:0042742	119	0.077
response to acid chemical	GO:0001101	111	0.077
negative regulation of molecular function	GO:0044092	258	0.076
cell cell recognition	GO:0009988	44	0.076
eosinophil activation	GO:0043307	1	0.076
renal system development	GO:0072001	225	0.076
regulation of acute inflammatory response	GO:0002673	27	0.076
cation homeostasis	GO:0055080	212	0.075
cardiac muscle tissue development	GO:0048738	130	0.075
homeostasis of number of cells	GO:0048872	210	0.074
regulation of interleukin 1 production	GO:0032652	26	0.074
cation transport	GO:0006812	399	0.074
lymphocyte proliferation	GO:0046651	164	0.074
regulation of kinase activity	GO:0043549	249	0.073
regulation of neuron projection development	GO:0010975	169	0.072
cellular lipid metabolic process	GO:0044255	323	0.071	Mouse
leukocyte homeostasis	GO:0001776	79	0.071
membrane organization	GO:0061024	245	0.071
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.071
myeloid leukocyte differentiation	GO:0002573	119	0.071
divalent inorganic cation homeostasis	GO:0072507	138	0.071
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.070
multicellular organismal homeostasis	GO:0048871	164	0.070	Mouse
respiratory system development	GO:0060541	190	0.069	Mouse
positive regulation of proteolysis	GO:0045862	85	0.069	Mouse
cytosolic calcium ion homeostasis	GO:0051480	70	0.068
cytokine mediated signaling pathway	GO:0019221	115	0.068
response to decreased oxygen levels	GO:0036293	59	0.067
ossification	GO:0001503	216	0.067	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.067
neurotransmitter secretion	GO:0007269	62	0.067
immune complex clearance	GO:0002434	2	0.066
positive regulation of leukocyte differentiation	GO:1902107	86	0.066
production of molecular mediator of immune response	GO:0002440	103	0.065
mature dendritic cell differentiation	GO:0097029	3	0.065
positive regulation of lymphocyte activation	GO:0051251	140	0.065
positive regulation of cell development	GO:0010720	237	0.065
alpha beta t cell activation	GO:0046631	91	0.065
erk1 and erk2 cascade	GO:0070371	77	0.065
regulation of organelle organization	GO:0033043	289	0.064
positive regulation of behavior	GO:0048520	40	0.063
regulation of cellular amine metabolic process	GO:0033238	20	0.062
interleukin 12 secretion	GO:0072610	3	0.062
cellular chemical homeostasis	GO:0055082	215	0.062
regulation of leukocyte apoptotic process	GO:2000106	56	0.062
mammary gland morphogenesis	GO:0060443	54	0.062
interleukin 8 production	GO:0032637	4	0.062
germ cell development	GO:0007281	185	0.062
positive regulation of cell death	GO:0010942	224	0.061	Mouse
muscle tissue development	GO:0060537	308	0.061
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.060
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.060
positive regulation of response to wounding	GO:1903036	66	0.060
organ growth	GO:0035265	117	0.059
positive regulation of neuron differentiation	GO:0045666	141	0.059
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.058
response to organic cyclic compound	GO:0014070	198	0.058
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.058
cellular amino acid metabolic process	GO:0006520	103	0.058
positive regulation of mapk cascade	GO:0043410	170	0.058
digestive tract morphogenesis	GO:0048546	147	0.057
regulation of body fluid levels	GO:0050878	162	0.057
negative regulation of fat cell differentiation	GO:0045599	36	0.057
regulation of hypersensitivity	GO:0002883	10	0.057
cellular response to prostaglandin d stimulus	GO:0071799	1	0.057
leukocyte proliferation	GO:0070661	172	0.057
positive regulation of protein secretion	GO:0050714	52	0.056
cell proliferation in hindbrain	GO:0021534	10	0.056
lymphocyte apoptotic process	GO:0070227	54	0.056
positive regulation of protein kinase activity	GO:0045860	144	0.056
regulation of cell migration	GO:0030334	219	0.056	Mouse
negative regulation of cell growth	GO:0030308	44	0.056
defense response to other organism	GO:0098542	197	0.055
myeloid leukocyte migration	GO:0097529	57	0.055
chondrocyte differentiation	GO:0002062	72	0.055	Mouse
positive regulation of t cell receptor signaling pathway	GO:0050862	4	0.055
positive regulation of secretion by cell	GO:1903532	114	0.055
regulation of smoothened signaling pathway	GO:0008589	58	0.054
negative regulation of phosphorus metabolic process	GO:0010563	184	0.054
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.054
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.054
leukocyte chemotaxis	GO:0030595	69	0.054
regulation of protein secretion	GO:0050708	82	0.054
regulation of cellular amino acid metabolic process	GO:0006521	5	0.054
regulation of interleukin 8 production	GO:0032677	3	0.053
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.053
regulation of metal ion transport	GO:0010959	106	0.053
positive regulation of neuron projection development	GO:0010976	79	0.053
regulation of cell projection organization	GO:0031344	206	0.052
digestive tract development	GO:0048565	190	0.051
t helper 17 cell chemotaxis	GO:0035705	1	0.051
regulation of protein localization	GO:0032880	231	0.051
regionalization	GO:0003002	337	0.050
sequestering of calcium ion	GO:0051208	18	0.050
muscle tissue morphogenesis	GO:0060415	53	0.050
trabecula morphogenesis	GO:0061383	40	0.049
response to oxidative stress	GO:0006979	123	0.049
regulation of innate immune response	GO:0045088	91	0.049
t cell migration	GO:0072678	19	0.049
cellular ketone metabolic process	GO:0042180	84	0.049
t cell differentiation in thymus	GO:0033077	77	0.049
negative regulation of defense response	GO:0031348	77	0.049
immune complex clearance by monocytes and macrophages	GO:0002436	2	0.048
positive regulation of hydrolase activity	GO:0051345	148	0.048	Mouse
immune effector process	GO:0002252	321	0.048
regulation of t cell activation	GO:0050863	170	0.048
positive regulation of acute inflammatory response	GO:0002675	16	0.048
regulation of immune complex clearance by monocytes and macrophages	GO:0090264	2	0.048
negative regulation of cell proliferation	GO:0008285	296	0.047	Rat
positive regulation of kinase activity	GO:0033674	155	0.047
hemostasis	GO:0007599	78	0.047
myeloid cell apoptotic process	GO:0033028	22	0.047
regulation of neuron differentiation	GO:0045664	281	0.047
positive regulation of bone remodeling	GO:0046852	13	0.047
hypersensitivity	GO:0002524	10	0.046
ras protein signal transduction	GO:0007265	77	0.046
granulocyte chemotaxis	GO:0071621	39	0.046
regulation of cell size	GO:0008361	72	0.046
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.046
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.046
regulation of protein serine threonine kinase activity	GO:0071900	157	0.045
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.045
cellular metal ion homeostasis	GO:0006875	151	0.045
mucopolysaccharide metabolic process	GO:1903510	25	0.045
negative regulation of growth	GO:0045926	99	0.045
regulation of mapk cascade	GO:0043408	248	0.045
regulation of tube size	GO:0035150	57	0.044
immune response regulating signaling pathway	GO:0002764	125	0.044
digestive system development	GO:0055123	200	0.044
cellular calcium ion homeostasis	GO:0006874	119	0.044
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.044
regulation of leukocyte mediated immunity	GO:0002703	104	0.044
eosinophil mediated immunity	GO:0002447	1	0.043
gland development	GO:0048732	330	0.043
platelet activation	GO:0030168	40	0.043
regulation of t cell costimulation	GO:2000523	2	0.043
neuron apoptotic process	GO:0051402	142	0.043
cellular response to molecule of bacterial origin	GO:0071219	83	0.043
regulation of neural precursor cell proliferation	GO:2000177	70	0.042
positive regulation of leukocyte apoptotic process	GO:2000108	21	0.042
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.042
cell matrix adhesion	GO:0007160	68	0.042	Mouse
vascular process in circulatory system	GO:0003018	62	0.042
regulation of dendritic cell chemotaxis	GO:2000508	1	0.042
multi multicellular organism process	GO:0044706	109	0.042
defense response to gram positive bacterium	GO:0050830	50	0.041
regulation of cardiac muscle tissue growth	GO:0055021	26	0.041
lymphocyte differentiation	GO:0030098	242	0.041
myeloid cell differentiation	GO:0030099	233	0.041
cd8 positive alpha beta t cell extravasation	GO:0035697	3	0.041
response to amino acid	GO:0043200	37	0.040
negative regulation of synapse assembly	GO:0051964	3	0.040
positive regulation of lymphocyte proliferation	GO:0050671	70	0.040
regulation of b cell activation	GO:0050864	81	0.040
immune response activating signal transduction	GO:0002757	116	0.040
regulation of organ growth	GO:0046620	61	0.040
macromolecule catabolic process	GO:0009057	281	0.040
carbohydrate derivative biosynthetic process	GO:1901137	183	0.040
positive regulation of interleukin 8 production	GO:0032757	2	0.040
cellular ion homeostasis	GO:0006873	165	0.039
neural precursor cell proliferation	GO:0061351	121	0.039
determination of left right symmetry	GO:0007368	80	0.039
organic acid biosynthetic process	GO:0016053	86	0.039
response to extracellular stimulus	GO:0009991	127	0.039
single organismal cell cell adhesion	GO:0016337	131	0.039	Mouse
glycoprotein biosynthetic process	GO:0009101	89	0.039
response to lipopolysaccharide	GO:0032496	128	0.039
leukocyte activation involved in immune response	GO:0002366	126	0.039
neutrophil migration	GO:1990266	37	0.039
dendrite development	GO:0016358	115	0.038
engulfment of apoptotic cell	GO:0043652	3	0.038
regulation of cd8 positive alpha beta t cell extravasation	GO:2000449	3	0.038
connective tissue development	GO:0061448	179	0.038	Mouse
negative regulation of eosinophil degranulation	GO:0043310	1	0.038
branching morphogenesis of an epithelial tube	GO:0048754	159	0.037
extracellular structure organization	GO:0043062	148	0.037	Mouse
regulation of vesicle mediated transport	GO:0060627	139	0.037
respiratory tube development	GO:0030323	167	0.037	Mouse
positive regulation of immune complex clearance by monocytes and macrophages	GO:0090265	2	0.037
organelle assembly	GO:0070925	177	0.037
interleukin 8 secretion	GO:0072606	3	0.037
regulation of inflammatory response to antigenic stimulus	GO:0002861	21	0.037
regulation of cellular response to stress	GO:0080135	159	0.037
appendage morphogenesis	GO:0035107	149	0.036
dendritic cell differentiation	GO:0097028	26	0.036
gastrulation	GO:0007369	116	0.036
regulation of blood vessel size	GO:0050880	56	0.036
regulation of cell adhesion	GO:0030155	154	0.036	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.035
oxidation reduction process	GO:0055114	342	0.035
nitrogen compound transport	GO:0071705	271	0.035
positive regulation of cellular component biogenesis	GO:0044089	94	0.035
positive regulation of stem cell proliferation	GO:2000648	59	0.035
positive regulation of t cell extravasation	GO:2000409	2	0.035
positive regulation of protein transport	GO:0051222	93	0.035
cellular amine metabolic process	GO:0044106	44	0.035
positive regulation of map kinase activity	GO:0043406	84	0.035
regulation of lipid metabolic process	GO:0019216	118	0.035	Mouse
regulation of peptidase activity	GO:0052547	96	0.035	Mouse
positive regulation of innate immune response	GO:0045089	80	0.034
b cell proliferation	GO:0042100	53	0.034
regulation of ion homeostasis	GO:2000021	64	0.034
regulation of interleukin 1 beta production	GO:0032651	25	0.034
antibacterial peptide biosynthetic process	GO:0002780	2	0.034
regulation of anatomical structure size	GO:0090066	178	0.034
interleukin 1 production	GO:0032612	31	0.034
cell adhesion	GO:0007155	329	0.034	Mouse
purine containing compound metabolic process	GO:0072521	311	0.034
macrophage chemotaxis	GO:0048246	14	0.034
regulation of immunological synapse formation	GO:2000520	2	0.034
developmental cell growth	GO:0048588	84	0.033
epidermis development	GO:0008544	187	0.033
positive regulation of leukocyte proliferation	GO:0070665	73	0.033
regulation of protein transport	GO:0051223	163	0.033
regulation of t cell extravasation	GO:2000407	3	0.033
regulation of cytokine biosynthetic process	GO:0042035	59	0.033
phagocytosis	GO:0006909	66	0.033
negative regulation of cell development	GO:0010721	169	0.033
positive regulation of immune effector process	GO:0002699	107	0.033
lymphocyte migration	GO:0072676	26	0.033
synaptic transmission	GO:0007268	329	0.033
peptidyl amino acid modification	GO:0018193	336	0.032
learning or memory	GO:0007611	148	0.032
positive regulation of angiogenesis	GO:0045766	46	0.032
ameboidal type cell migration	GO:0001667	128	0.032
positive regulation of hematopoietic stem cell migration	GO:2000473	1	0.032
regulation of blood pressure	GO:0008217	93	0.032
morphogenesis of embryonic epithelium	GO:0016331	159	0.032
response to steroid hormone	GO:0048545	56	0.032
peptide metabolic process	GO:0006518	46	0.031
negative regulation of immune system process	GO:0002683	209	0.031
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	GO:2000526	1	0.031
skeletal system development	GO:0001501	356	0.031	Mouse
positive regulation of immunological synapse formation	GO:2000522	1	0.031
nephron development	GO:0072006	109	0.031
forebrain development	GO:0030900	302	0.031
response to organophosphorus	GO:0046683	22	0.031
positive regulation of cytokine secretion	GO:0050715	41	0.031
regulation of leukocyte degranulation	GO:0043300	20	0.031
activation of immune response	GO:0002253	138	0.031
wnt signaling pathway	GO:0016055	188	0.031
negative regulation of cell adhesion	GO:0007162	45	0.031
monocyte extravasation	GO:0035696	2	0.030
response to transforming growth factor beta	GO:0071559	88	0.030
detection of stimulus	GO:0051606	84	0.030
regulation of alpha beta t cell activation	GO:0046634	53	0.030
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.030	Mouse
b cell homeostasis	GO:0001782	34	0.030
negative regulation of response to wounding	GO:1903035	77	0.030
positive regulation of interleukin 8 secretion	GO:2000484	1	0.030
negative regulation of cell activation	GO:0050866	111	0.030
neurotransmitter transport	GO:0006836	76	0.030
cytokine metabolic process	GO:0042107	71	0.030
regulation of hematopoietic stem cell migration	GO:2000471	1	0.030
cellular homeostasis	GO:0019725	240	0.030
embryonic limb morphogenesis	GO:0030326	126	0.029
developmental maturation	GO:0021700	193	0.029
sensory organ morphogenesis	GO:0090596	242	0.029
purine ribonucleoside metabolic process	GO:0046128	241	0.029
anatomical structure homeostasis	GO:0060249	145	0.029	Mouse
response to radiation	GO:0009314	165	0.029
amine metabolic process	GO:0009308	45	0.029
phosphatidylinositol mediated signaling	GO:0048015	41	0.029
regulation of wound healing	GO:0061041	40	0.029
microglial cell activation involved in immune response	GO:0002282	1	0.029
organelle localization	GO:0051640	179	0.029
peptidyl tyrosine phosphorylation	GO:0018108	143	0.029
negative regulation of intracellular signal transduction	GO:1902532	167	0.029
negative regulation of vasculature development	GO:1901343	26	0.029
bone resorption	GO:0045453	38	0.028
forebrain cell migration	GO:0021885	58	0.028
regulation of interleukin 1 beta secretion	GO:0050706	15	0.028
positive regulation of camp mediated signaling	GO:0043950	3	0.028
thymocyte migration	GO:0072679	2	0.028
positive regulation of eosinophil migration	GO:2000418	2	0.028
endothelial cell proliferation	GO:0001935	27	0.028
hematopoietic stem cell migration	GO:0035701	1	0.028
lipid transport	GO:0006869	98	0.028
myotube differentiation	GO:0014902	105	0.028
regulation of cartilage development	GO:0061035	44	0.027	Mouse
bone development	GO:0060348	120	0.027
negative regulation of neuron differentiation	GO:0045665	101	0.027
axonogenesis	GO:0007409	274	0.027
regulation of t cell proliferation	GO:0042129	92	0.027
positive regulation of cell substrate adhesion	GO:0010811	47	0.027	Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.027
regulation of lymphocyte activation	GO:0051249	240	0.027
embryonic placenta development	GO:0001892	98	0.027	Mouse
adaptive immune response	GO:0002250	155	0.027
positive regulation of homeostatic process	GO:0032846	64	0.027
defense response to gram negative bacterium	GO:0050829	28	0.027
antibacterial peptide secretion	GO:0002779	1	0.027
monocarboxylic acid metabolic process	GO:0032787	191	0.026
intrinsic apoptotic signaling pathway	GO:0097193	132	0.026
limb morphogenesis	GO:0035108	149	0.026
purine nucleotide metabolic process	GO:0006163	302	0.026
cellular response to biotic stimulus	GO:0071216	92	0.026
syncytium formation by plasma membrane fusion	GO:0000768	42	0.026
trabecula formation	GO:0060343	24	0.026
negative regulation of inflammatory response	GO:0050728	61	0.026
response to reactive oxygen species	GO:0000302	56	0.026
positive regulation of t cell activation	GO:0050870	101	0.026
negative regulation of b cell activation	GO:0050869	27	0.026
limb development	GO:0060173	166	0.025
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.025
regulation of monocyte extravasation	GO:2000437	2	0.025
regulation of fat cell differentiation	GO:0045598	81	0.025
regulation of cellular response to oxidative stress	GO:1900407	19	0.025
male gamete generation	GO:0048232	285	0.025
negative regulation of cell substrate adhesion	GO:0010812	16	0.025
cardiocyte differentiation	GO:0035051	87	0.025
negative regulation of nervous system development	GO:0051961	156	0.025
cellular extravasation	GO:0045123	17	0.025
mesenchyme development	GO:0060485	152	0.025
regulation of eosinophil degranulation	GO:0043309	1	0.025
endocytosis	GO:0006897	168	0.025
negative regulation of phosphate metabolic process	GO:0045936	184	0.024
positive regulation of alpha beta t cell activation	GO:0046635	39	0.024
transmembrane transport	GO:0055085	412	0.024
positive regulation of calcium ion transport	GO:0051928	27	0.024
regulation of coagulation	GO:0050818	31	0.024
cardiac septum development	GO:0003279	59	0.024	Mouse
microglial cell activation	GO:0001774	3	0.024
alcohol metabolic process	GO:0006066	116	0.024
neutrophil chemotaxis	GO:0030593	36	0.024
regulation of leukocyte differentiation	GO:1902105	159	0.024
ear development	GO:0043583	200	0.023
apoptotic process involved in morphogenesis	GO:0060561	25	0.023	Mouse
skin development	GO:0043588	220	0.023
positive regulation of canonical wnt signaling pathway	GO:0090263	29	0.023
negative regulation of macrophage apoptotic process	GO:2000110	3	0.023
regulation of muscle tissue development	GO:1901861	97	0.023
type 2 immune response	GO:0042092	23	0.023
regulation of transferase activity	GO:0051338	263	0.023
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.023
cytosolic calcium ion transport	GO:0060401	48	0.023
response to oxygen levels	GO:0070482	62	0.023
positive regulation of wnt signaling pathway	GO:0030177	45	0.023
dna metabolic process	GO:0006259	303	0.023
regulation of voltage gated calcium channel activity	GO:1901385	4	0.023
regulation of interleukin 8 secretion	GO:2000482	2	0.023
regulation of exocytosis	GO:0017157	61	0.022
fibroblast growth factor receptor signaling pathway	GO:0008543	46	0.022	Mouse
cardiac muscle cell development	GO:0055013	39	0.022
regulation of embryonic development	GO:0045995	71	0.022
reactive oxygen species biosynthetic process	GO:1903409	8	0.022
phenol containing compound metabolic process	GO:0018958	60	0.022
regulation of cytoskeleton organization	GO:0051493	122	0.022
protein catabolic process	GO:0030163	221	0.022
acid secretion	GO:0046717	33	0.022
regulation of lipase activity	GO:0060191	15	0.022	Mouse
regulation of cellular component size	GO:0032535	121	0.022
positive regulation of epithelial cell proliferation	GO:0050679	68	0.022
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.022
regulation of myotube differentiation	GO:0010830	62	0.022
central nervous system neuron differentiation	GO:0021953	162	0.022
ear morphogenesis	GO:0042471	118	0.022
sensory perception	GO:0007600	245	0.022
myeloid leukocyte mediated immunity	GO:0002444	42	0.022
positive regulation of inflammatory response to antigenic stimulus	GO:0002863	11	0.022
placenta development	GO:0001890	140	0.021	Mouse
regulation of stress fiber assembly	GO:0051492	15	0.021
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.021
positive regulation of thymocyte migration	GO:2000412	2	0.021
cellularization	GO:0007349	1	0.021
development of primary female sexual characteristics	GO:0046545	73	0.021
gliogenesis	GO:0042063	141	0.021
positive regulation of adaptive immune response	GO:0002821	61	0.021
neuron death	GO:0070997	154	0.021
nucleobase containing small molecule metabolic process	GO:0055086	352	0.021
endomembrane system organization	GO:0010256	147	0.021
regulation of epithelial cell proliferation	GO:0050678	141	0.021
regulation of mesenchymal cell proliferation	GO:0010464	37	0.021
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.021
negative regulation of protein metabolic process	GO:0051248	282	0.021

Wisp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.070
nervous system disease	DOID:863	0.070
retinal disease	DOID:5679	0.070
eye disease	DOID:5614	0.070
eye and adnexa disease	DOID:1492	0.070
sensory system disease	DOID:0050155	0.070
retinal degeneration	DOID:8466	0.030
gastrointestinal system disease	DOID:77	0.021

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