IMP: Integrative Multi-species Prediction

Mus musculus

79 known processes

Gcgr

glucagon receptor

(Aliases: GR)

Entrez: 14527
Ensembl: ENSMUSG00000025127
UniProtKB: Q61606
UniProtKB: Q3UN81

Process Predictions
Disease Predictions

Gcgr biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cation homeostasis	GO:0055080	212	0.676	Mouse
amine metabolic process	GO:0009308	45	0.669
regulation of kinase activity	GO:0043549	249	0.655
transmembrane transport	GO:0055085	412	0.640
nitrogen compound transport	GO:0071705	271	0.636	Mouse
regulation of hormone levels	GO:0010817	211	0.618	Mouse
ion transmembrane transport	GO:0034220	361	0.599
regulation of secretion by cell	GO:1903530	249	0.595	Mouse
regulation of response to wounding	GO:1903034	189	0.556
regulation of transferase activity	GO:0051338	263	0.554
cell adhesion	GO:0007155	329	0.531
organic hydroxy compound transport	GO:0015850	93	0.526	Mouse
regulation of body fluid levels	GO:0050878	162	0.503	Mouse
circulatory system process	GO:0003013	197	0.480	Mouse
regulation of intestinal cholesterol absorption	GO:0030300	4	0.469
cellular lipid metabolic process	GO:0044255	323	0.466
cellular amino acid metabolic process	GO:0006520	103	0.459
cation transport	GO:0006812	399	0.457
response to nutrient levels	GO:0031667	109	0.440
negative regulation of molecular function	GO:0044092	258	0.431
regulation of system process	GO:0044057	200	0.425	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.412
regulation of secretion	GO:0051046	274	0.408	Mouse
inflammatory response	GO:0006954	244	0.407
cellular amine metabolic process	GO:0044106	44	0.388
lipid catabolic process	GO:0016042	69	0.382
cellular metal ion homeostasis	GO:0006875	151	0.378	Mouse
organic hydroxy compound metabolic process	GO:1901615	203	0.378
very low density lipoprotein particle remodeling	GO:0034372	1	0.370
regulation of anatomical structure size	GO:0090066	178	0.363
monocarboxylic acid metabolic process	GO:0032787	191	0.362
energy derivation by oxidation of organic compounds	GO:0015980	77	0.350
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.346
hemostasis	GO:0007599	78	0.345
forebrain development	GO:0030900	302	0.337	Mouse
blood coagulation	GO:0007596	76	0.337
gland development	GO:0048732	330	0.336	Mouse
neutral lipid metabolic process	GO:0006638	57	0.335
peptide hormone secretion	GO:0030072	109	0.325	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.318
plasma lipoprotein particle remodeling	GO:0034369	6	0.315
positive regulation of protein phosphorylation	GO:0001934	242	0.312
positive regulation of kinase activity	GO:0033674	155	0.311
hexose metabolic process	GO:0019318	98	0.307
g protein coupled receptor signaling pathway	GO:0007186	243	0.305
cellular chemical homeostasis	GO:0055082	215	0.302	Mouse
acylglycerol metabolic process	GO:0006639	55	0.301
anion transport	GO:0006820	177	0.293
regulation of cell migration	GO:0030334	219	0.289
response to organic cyclic compound	GO:0014070	198	0.287
organic acid transport	GO:0015849	101	0.287
response to organonitrogen compound	GO:0010243	246	0.286
cellular lipid catabolic process	GO:0044242	52	0.283
anion transmembrane transport	GO:0098656	71	0.282
monoamine transport	GO:0015844	33	0.280
carboxylic acid transport	GO:0046942	100	0.274
generation of precursor metabolites and energy	GO:0006091	103	0.269
hormone secretion	GO:0046879	128	0.268	Mouse
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.268	Mouse
fat cell differentiation	GO:0045444	160	0.266
cytokine production	GO:0001816	319	0.260
regulation of membrane potential	GO:0042391	192	0.254
response to extracellular stimulus	GO:0009991	127	0.251
coagulation	GO:0050817	78	0.249
regulation of cellular amine metabolic process	GO:0033238	20	0.248
cellular response to peptide	GO:1901653	92	0.245
regulation of cell motility	GO:2000145	236	0.243
cellular phosphate ion homeostasis	GO:0030643	2	0.241
negative regulation of response to wounding	GO:1903035	77	0.238
blood circulation	GO:0008015	195	0.238	Mouse
monosaccharide metabolic process	GO:0005996	106	0.233
response to metal ion	GO:0010038	47	0.232
cellular carbohydrate metabolic process	GO:0044262	119	0.232
peptidyl tyrosine modification	GO:0018212	145	0.228
positive regulation of transferase activity	GO:0051347	167	0.225
diterpenoid metabolic process	GO:0016101	24	0.224
digestive system development	GO:0055123	200	0.224
regulation of lipid metabolic process	GO:0019216	118	0.217
cellular ketone metabolic process	GO:0042180	84	0.209
cellular response to external stimulus	GO:0071496	88	0.207
monocarboxylic acid catabolic process	GO:0072329	27	0.205
fatty acid metabolic process	GO:0006631	121	0.205
positive regulation of cell development	GO:0010720	237	0.202
positive regulation of cytokine production	GO:0001819	174	0.202
positive regulation of peptide hormone secretion	GO:0090277	31	0.202	Mouse
digestive tract development	GO:0048565	190	0.200
nucleoside triphosphate metabolic process	GO:0009141	230	0.195
synaptic transmission	GO:0007268	329	0.193
tissue remodeling	GO:0048771	102	0.192	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.191
steroid metabolic process	GO:0008202	119	0.190
positive regulation of secretion	GO:0051047	130	0.190	Mouse
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	24	0.187	Mouse
ribonucleoside metabolic process	GO:0009119	245	0.185
cellular ion homeostasis	GO:0006873	165	0.184	Mouse
alpha amino acid metabolic process	GO:1901605	59	0.183
rhythmic process	GO:0048511	174	0.181
regulation of homeostatic process	GO:0032844	182	0.179
protein processing	GO:0016485	163	0.172
organic anion transport	GO:0015711	137	0.167
peptide transport	GO:0015833	133	0.166	Mouse
tissue migration	GO:0090130	68	0.163
positive regulation of glycolytic process	GO:0045821	4	0.161
cellular polysaccharide metabolic process	GO:0044264	38	0.160
response to peptide hormone	GO:0043434	127	0.160
cholesterol metabolic process	GO:0008203	56	0.160
regulation of cellular amino acid metabolic process	GO:0006521	5	0.158
positive regulation of secretion by cell	GO:1903532	114	0.156	Mouse
amide transport	GO:0042886	138	0.155	Mouse
acid secretion	GO:0046717	33	0.150
positive regulation of protein secretion	GO:0050714	52	0.148
carbohydrate metabolic process	GO:0005975	230	0.147
muscle cell differentiation	GO:0042692	261	0.146
brown fat cell differentiation	GO:0050873	36	0.145
cholesterol esterification	GO:0034435	3	0.144
vascular process in circulatory system	GO:0003018	62	0.144
phospholipid metabolic process	GO:0006644	87	0.143
regulation of steroid metabolic process	GO:0019218	39	0.142
small molecule biosynthetic process	GO:0044283	132	0.140
peristalsis	GO:0030432	8	0.139
wound healing	GO:0042060	157	0.138
cognition	GO:0050890	149	0.138	Mouse
ameboidal type cell migration	GO:0001667	128	0.137
connective tissue development	GO:0061448	179	0.136	Mouse
regulation of hormone secretion	GO:0046883	88	0.136	Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.135
protein secretion	GO:0009306	111	0.135
glycolytic process	GO:0006096	20	0.134
regulation of nitrogen cycle metabolic process	GO:1903314	1	0.134
one carbon metabolic process	GO:0006730	1	0.133
regulation of protein secretion	GO:0050708	82	0.131
regulation of protein kinase activity	GO:0045859	232	0.131
cellular homeostasis	GO:0019725	240	0.131	Mouse
regulation of steroid biosynthetic process	GO:0050810	26	0.130
negative regulation of coagulation	GO:0050819	11	0.129
catecholamine transport	GO:0051937	21	0.128
regulation of ion transport	GO:0043269	215	0.128
peptidyl amino acid modification	GO:0018193	336	0.128
sterol metabolic process	GO:0016125	58	0.128
regulation of carbohydrate metabolic process	GO:0006109	75	0.124
alcohol metabolic process	GO:0006066	116	0.124
positive regulation of mapk cascade	GO:0043410	170	0.124
oxidation reduction process	GO:0055114	342	0.123
cellular response to organonitrogen compound	GO:0071417	145	0.121
central nervous system neuron differentiation	GO:0021953	162	0.119
morphogenesis of a branching structure	GO:0001763	203	0.117
hormone metabolic process	GO:0042445	86	0.117	Mouse
polysaccharide metabolic process	GO:0005976	39	0.117
regulation of appetite	GO:0032098	12	0.115
regulation of coagulation	GO:0050818	31	0.114
regulation of vasculature development	GO:1901342	88	0.113	Mouse
neurotransmitter transport	GO:0006836	76	0.112
regulation of blood vessel size	GO:0050880	56	0.112
cofactor transport	GO:0051181	4	0.112
triglyceride rich lipoprotein particle remodeling	GO:0034370	2	0.112
purine containing compound metabolic process	GO:0072521	311	0.111	Mouse
small molecule catabolic process	GO:0044282	71	0.111
positive regulation of lipid metabolic process	GO:0045834	40	0.110
cation transmembrane transport	GO:0098655	266	0.109
retinoid metabolic process	GO:0001523	24	0.108
response to alkaloid	GO:0043279	34	0.107
positive regulation of insulin receptor signaling pathway	GO:0046628	4	0.106
regulation of neurotransmitter levels	GO:0001505	87	0.106
cellular calcium ion homeostasis	GO:0006874	119	0.103	Mouse
purine ribonucleoside catabolic process	GO:0046130	205	0.101
multicellular organismal signaling	GO:0035637	91	0.100
regulation of carbohydrate catabolic process	GO:0043470	12	0.099
lipid biosynthetic process	GO:0008610	179	0.099
urogenital system development	GO:0001655	261	0.099
organic cyclic compound catabolic process	GO:1901361	295	0.099
glycerolipid metabolic process	GO:0046486	122	0.098
nucleotide catabolic process	GO:0009166	217	0.097
positive regulation of cell migration	GO:0030335	109	0.096
organonitrogen compound biosynthetic process	GO:1901566	192	0.096	Mouse
response to starvation	GO:0042594	65	0.096
divalent inorganic cation homeostasis	GO:0072507	138	0.096	Mouse
cell substrate adhesion	GO:0031589	130	0.096
response to peptide	GO:1901652	136	0.094
carbohydrate derivative biosynthetic process	GO:1901137	183	0.093	Mouse
response to dietary excess	GO:0002021	18	0.093
regulation of insulin receptor signaling pathway	GO:0046626	21	0.093
lipoprotein catabolic process	GO:0042159	7	0.092
amino acid transmembrane transport	GO:0003333	37	0.091
purine nucleotide metabolic process	GO:0006163	302	0.091	Mouse
sodium ion transport	GO:0006814	73	0.090
carboxylic acid biosynthetic process	GO:0046394	86	0.089
purine ribonucleotide metabolic process	GO:0009150	290	0.089	Mouse
response to amphetamine	GO:0001975	16	0.088
regulation of smooth muscle contraction	GO:0006940	22	0.088
metal ion homeostasis	GO:0055065	189	0.088	Mouse
immune effector process	GO:0002252	321	0.087
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.087
negative regulation of hemostasis	GO:1900047	11	0.086
epithelium migration	GO:0090132	63	0.086
blood vessel morphogenesis	GO:0048514	285	0.086	Mouse
cellular glucan metabolic process	GO:0006073	32	0.086
fatty acid catabolic process	GO:0009062	25	0.086
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	26	0.085	Mouse
regulation of blood coagulation	GO:0030193	28	0.085
positive regulation of cellular catabolic process	GO:0031331	148	0.084
regulation of hydrolase activity	GO:0051336	246	0.084
positive regulation of renal sodium excretion	GO:0035815	2	0.083
glial cell differentiation	GO:0010001	131	0.083
cellular response to extracellular stimulus	GO:0031668	81	0.083
sodium ion transmembrane transport	GO:0035725	49	0.082
apoptotic signaling pathway	GO:0097190	306	0.082
response to drug	GO:0042493	75	0.081
regulation of blood circulation	GO:1903522	93	0.081	Mouse
regulation of phosphatidylinositol 3 kinase signaling	GO:0014066	30	0.081
single organism cell adhesion	GO:0098602	156	0.081
vasodilation	GO:0042311	28	0.080
regulation of ammonia assimilation cycle	GO:2001248	1	0.080
endocrine system development	GO:0035270	98	0.080	Mouse
gastrin induced gastric acid secretion	GO:0001698	1	0.079
regulation of activation of jak2 kinase activity	GO:0010534	1	0.079
carboxylic acid catabolic process	GO:0046395	51	0.079
memory	GO:0007613	58	0.078
positive regulation of protein kinase activity	GO:0045860	144	0.078
synapse organization	GO:0050808	125	0.078
terpenoid metabolic process	GO:0006721	25	0.077
second messenger mediated signaling	GO:0019932	73	0.076	Mouse
regulation of wound healing	GO:0061041	40	0.076
regulation of tube size	GO:0035150	57	0.076
regulation of ion homeostasis	GO:2000021	64	0.075
body fluid secretion	GO:0007589	53	0.075	Mouse
digestion	GO:0007586	40	0.074
purine nucleotide catabolic process	GO:0006195	211	0.074
energy reserve metabolic process	GO:0006112	39	0.074
glucose metabolic process	GO:0006006	92	0.074
glucocorticoid biosynthetic process	GO:0006704	5	0.074
phasic smooth muscle contraction	GO:0014821	8	0.073
regulation of glutamate metabolic process	GO:2000211	1	0.073
peptide secretion	GO:0002790	114	0.072	Mouse
regulation of cellular catabolic process	GO:0031329	242	0.072
organic acid biosynthetic process	GO:0016053	86	0.071
positive regulation of dopamine uptake involved in synaptic transmission	GO:0051586	2	0.070
regulation of protein transport	GO:0051223	163	0.070
fat soluble vitamin biosynthetic process	GO:0042362	4	0.070
purine ribonucleotide catabolic process	GO:0009154	208	0.070
circadian rhythm	GO:0007623	114	0.069
sensory perception	GO:0007600	245	0.069
organic hydroxy compound biosynthetic process	GO:1901617	77	0.068
cellular response to abiotic stimulus	GO:0071214	56	0.068
gtp metabolic process	GO:0046039	144	0.068
norepinephrine transport	GO:0015874	2	0.068
regulation of mapk cascade	GO:0043408	248	0.067
regulation of blood pressure	GO:0008217	93	0.067
retinal blood vessel morphogenesis	GO:0061304	3	0.067
regulation of hemostasis	GO:1900046	28	0.066
cellular macromolecule catabolic process	GO:0044265	206	0.066
calcium ion homeostasis	GO:0055074	127	0.066	Mouse
negative regulation of protein metabolic process	GO:0051248	282	0.066
multicellular organism growth	GO:0035264	161	0.066	Mouse
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.066
midbrain hindbrain boundary maturation	GO:0021732	1	0.065
regulation of apoptotic signaling pathway	GO:2001233	197	0.065
regulation of cellular component biogenesis	GO:0044087	181	0.065
regulation of vitamin metabolic process	GO:0030656	3	0.065
heterocycle catabolic process	GO:0046700	280	0.064
transmission of nerve impulse	GO:0019226	76	0.064
reactive nitrogen species metabolic process	GO:2001057	0	0.064
inorganic cation transmembrane transport	GO:0098662	207	0.064
negative regulation of blood coagulation	GO:0030195	11	0.064
neuronal action potential	GO:0019228	54	0.064
negative regulation of inflammatory response	GO:0050728	61	0.064
positive regulation of protein modification process	GO:0031401	299	0.064
regulation of synaptic transmission glutamatergic	GO:0051966	19	0.064
regulation of sterol transport	GO:0032371	17	0.063
response to nicotine	GO:0035094	6	0.063
exocrine system development	GO:0035272	45	0.062
divalent metal ion transport	GO:0070838	172	0.062
muscle contraction	GO:0006936	101	0.062
small gtpase mediated signal transduction	GO:0007264	97	0.062
regulation of peptide hormone secretion	GO:0090276	75	0.061	Mouse
inner ear morphogenesis	GO:0042472	101	0.060
organic acid catabolic process	GO:0016054	51	0.059
lipoprotein metabolic process	GO:0042157	43	0.059
regulation of proteolysis	GO:0030162	164	0.059
heart contraction	GO:0060047	93	0.059	Mouse
camera type eye development	GO:0043010	266	0.058
hair cycle	GO:0042633	90	0.058
epithelial tube morphogenesis	GO:0060562	303	0.057
regulation of peptide secretion	GO:0002791	77	0.057	Mouse
spermatogenesis	GO:0007283	284	0.057
activation of adenylate cyclase activity	GO:0007190	4	0.057
negative regulation of cell motility	GO:2000146	61	0.057
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.057
regulation of glutamine family amino acid metabolic process	GO:0000820	1	0.057
epithelial cell migration	GO:0010631	63	0.056
skeletal system development	GO:0001501	356	0.055	Mouse
glucocorticoid metabolic process	GO:0008211	9	0.055
insulin secretion	GO:0030073	89	0.055
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.055
smooth muscle contraction	GO:0006939	44	0.055
steroid esterification	GO:0034433	3	0.055
glucose homeostasis	GO:0042593	128	0.055
regulation of protein localization	GO:0032880	231	0.055
positive regulation of insulin secretion	GO:0032024	26	0.055
dopamine transport	GO:0015872	15	0.054
sensory perception of pain	GO:0019233	47	0.054
cholesterol transport	GO:0030301	38	0.054
sensory perception of light stimulus	GO:0050953	54	0.054
amino acid transport	GO:0006865	61	0.054
folic acid containing compound metabolic process	GO:0006760	3	0.054
positive regulation of the force of heart contraction by epinephrine norepinephrine	GO:0001997	3	0.053
negative regulation of cell migration	GO:0030336	59	0.053
triglyceride metabolic process	GO:0006641	51	0.053
visual perception	GO:0007601	52	0.053
response to bile acid	GO:1903412	1	0.052
carbohydrate derivative catabolic process	GO:1901136	231	0.052
acylglycerol homeostasis	GO:0055090	16	0.052
regulation of fatty acid metabolic process	GO:0019217	28	0.052
embryonic placenta development	GO:0001892	98	0.051
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.051
cell growth	GO:0016049	130	0.051
regulation of inflammatory response	GO:0050727	147	0.051
cofactor metabolic process	GO:0051186	80	0.051
macromolecule catabolic process	GO:0009057	281	0.050
negative regulation of cellular response to insulin stimulus	GO:1900077	16	0.050
carbohydrate biosynthetic process	GO:0016051	74	0.050
regulation of cell adhesion mediated by integrin	GO:0033628	13	0.050
single organismal cell cell adhesion	GO:0016337	131	0.050
pyruvate metabolic process	GO:0006090	28	0.050
response to inorganic substance	GO:0010035	96	0.049
glutamate receptor signaling pathway	GO:0007215	35	0.049
response to insulin	GO:0032868	100	0.049	Mouse
protein lipid complex subunit organization	GO:0071825	12	0.049
isoprenoid metabolic process	GO:0006720	29	0.049
regulation of activation of janus kinase activity	GO:0010533	1	0.049
anatomical structure homeostasis	GO:0060249	145	0.049	Mouse
peptidyl tyrosine phosphorylation	GO:0018108	143	0.049
ribonucleotide metabolic process	GO:0009259	291	0.048	Mouse
sterol esterification	GO:0034434	3	0.048
associative learning	GO:0008306	61	0.048
adipose tissue development	GO:0060612	25	0.048
pancreas development	GO:0031016	57	0.048	Mouse
purine ribonucleoside metabolic process	GO:0046128	241	0.047
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway	GO:0051482	4	0.047
positive regulation of apoptotic process	GO:0043065	217	0.047
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.047
purine ribonucleotide biosynthetic process	GO:0009152	59	0.047	Mouse
nucleoside phosphate metabolic process	GO:0006753	338	0.047	Mouse
glycogen metabolic process	GO:0005977	32	0.047
lung development	GO:0030324	164	0.046
negative regulation of wound healing	GO:0061045	14	0.046
ribonucleotide catabolic process	GO:0009261	208	0.046
regulation of glucose metabolic process	GO:0010906	60	0.046
divalent inorganic cation transport	GO:0072511	178	0.046
positive regulation of hormone secretion	GO:0046887	38	0.046	Mouse
regulation of cytokine production	GO:0001817	266	0.046
protein maturation	GO:0051604	176	0.045
negative regulation of serotonin secretion	GO:0014063	2	0.045
establishment of organelle localization	GO:0051656	122	0.045
rho protein signal transduction	GO:0007266	32	0.045
locomotory behavior	GO:0007626	195	0.045
negative regulation of cellular protein metabolic process	GO:0032269	247	0.045
glycosyl compound catabolic process	GO:1901658	206	0.044
action potential	GO:0001508	78	0.044
nucleotide metabolic process	GO:0009117	332	0.044	Mouse
carbohydrate catabolic process	GO:0016052	32	0.044
cellular response to cadmium ion	GO:0071276	3	0.044
morphogenesis of a branching epithelium	GO:0061138	193	0.044
inorganic ion transmembrane transport	GO:0098660	234	0.043
positive regulation of homeostatic process	GO:0032846	64	0.043
cellular response to starvation	GO:0009267	57	0.043
oxygen homeostasis	GO:0032364	2	0.043
regulation of camp metabolic process	GO:0030814	30	0.043	Mouse
cellular divalent inorganic anion homeostasis	GO:0072501	3	0.043
histamine induced gastric acid secretion	GO:0001697	1	0.043
ossification	GO:0001503	216	0.042	Mouse
regulation of cholesterol esterification	GO:0010872	2	0.042
regulation of cell adhesion	GO:0030155	154	0.042
type b pancreatic cell proliferation	GO:0044342	10	0.042
regulation of cholesterol transport	GO:0032374	17	0.042
response to monosaccharide	GO:0034284	67	0.042
nucleoside phosphate catabolic process	GO:1901292	222	0.041
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.041
aromatic compound catabolic process	GO:0019439	286	0.041
positive regulation of cholesterol esterification	GO:0010873	1	0.041
inositol lipid mediated signaling	GO:0048017	41	0.040
positive regulation of fatty acid biosynthetic process	GO:0045723	3	0.040
positive regulation of the force of heart contraction by chemical signal	GO:0003099	3	0.040
placenta blood vessel development	GO:0060674	31	0.040
placenta development	GO:0001890	140	0.040
telencephalon development	GO:0021537	186	0.040
purine nucleoside catabolic process	GO:0006152	205	0.040
renal system development	GO:0072001	225	0.040
glycoprotein metabolic process	GO:0009100	116	0.039
detection of stimulus	GO:0051606	84	0.039
endothelial cell migration	GO:0043542	44	0.039
negative regulation of cellular component organization	GO:0051129	194	0.039
muscle system process	GO:0003012	141	0.039
cellular response to insulin stimulus	GO:0032869	78	0.039	Mouse
habituation	GO:0046959	3	0.039
respiratory tube development	GO:0030323	167	0.038
erk1 and erk2 cascade	GO:0070371	77	0.038
establishment of blood nerve barrier	GO:0008065	3	0.038
activation of janus kinase activity	GO:0042976	2	0.038
multicellular organismal response to stress	GO:0033555	62	0.037	Mouse
mesonephric tubule development	GO:0072164	94	0.037
monocarboxylic acid biosynthetic process	GO:0072330	61	0.037
regulation of bone mineralization	GO:0030500	31	0.037
regulation of metal ion transport	GO:0010959	106	0.037
g protein coupled receptor internalization	GO:0002031	3	0.037
cellular response to peptide hormone stimulus	GO:0071375	92	0.037
operant conditioning	GO:0035106	2	0.037
regulation of cell projection organization	GO:0031344	206	0.037
mapk cascade	GO:0000165	281	0.037
regulation of purine nucleotide metabolic process	GO:1900542	169	0.037	Mouse
positive regulation of nervous system development	GO:0051962	221	0.037
inner medullary collecting duct development	GO:0072061	2	0.036
cellular response to temperature stimulus	GO:0071502	2	0.036
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.036
vitamin d biosynthetic process	GO:0042368	3	0.036
purine containing compound catabolic process	GO:0072523	213	0.036
gliogenesis	GO:0042063	141	0.036
ribose phosphate metabolic process	GO:0019693	291	0.036	Mouse
kidney epithelium development	GO:0072073	121	0.036
sensory organ morphogenesis	GO:0090596	242	0.036
bile acid secretion	GO:0032782	2	0.036
negative regulation of phosphate metabolic process	GO:0045936	184	0.035
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.035
cytokine secretion	GO:0050663	72	0.035
positive regulation of catecholamine uptake involved in synaptic transmission	GO:0051944	2	0.035
cellular response to lipid	GO:0071396	145	0.035
central nervous system neuron development	GO:0021954	67	0.035
vasodilation by norepinephrine epinephrine involved in regulation of systemic arterial blood pressure	GO:0002025	3	0.035
circadian regulation of gene expression	GO:0032922	48	0.035
positive regulation of cell motility	GO:2000147	116	0.035
positive regulation of cytokine secretion	GO:0050715	41	0.035
regulation of peptide transport	GO:0090087	91	0.035	Mouse
cellular glucose homeostasis	GO:0001678	52	0.035
jak stat cascade	GO:0007259	42	0.035
mammary gland duct morphogenesis	GO:0060603	38	0.035
liver development	GO:0001889	66	0.035
positive regulation of heart rate by epinephrine norepinephrine	GO:0001996	4	0.034
lipid modification	GO:0030258	65	0.034
regulation of nucleotide metabolic process	GO:0006140	169	0.034	Mouse
regulation of t cell activation	GO:0050863	170	0.034
response to phenylpropanoid	GO:0080184	22	0.034
platelet activation	GO:0030168	40	0.034
kidney development	GO:0001822	213	0.034
g protein coupled acetylcholine receptor signaling pathway	GO:0007213	4	0.034
regulation of cell cycle	GO:0051726	281	0.034
ubiquitin dependent smad protein catabolic process	GO:0030579	2	0.034
urate transport	GO:0015747	1	0.034
regulation of lymphocyte activation	GO:0051249	240	0.034
cholesterol catabolic process	GO:0006707	5	0.033
regulation of systemic arterial blood pressure by norepinephrine epinephrine	GO:0001993	8	0.033
cerebral cortex development	GO:0021987	86	0.033
renal system process	GO:0003014	48	0.033
ras protein signal transduction	GO:0007265	77	0.033
positive regulation of cellular component biogenesis	GO:0044089	94	0.033
ribonucleoside catabolic process	GO:0042454	206	0.033
positive regulation of blood circulation	GO:1903524	22	0.033
polarity specification of proximal distal axis	GO:0010085	2	0.033
monocarboxylic acid transport	GO:0015718	44	0.033
maintenance of location	GO:0051235	89	0.033
angiogenesis	GO:0001525	201	0.033	Mouse
nucleoside metabolic process	GO:0009116	246	0.033
glycosyl compound metabolic process	GO:1901657	246	0.033
cellular response to bile acid	GO:1903413	1	0.032
regulation of endopeptidase activity	GO:0052548	89	0.032
regulation of muscle system process	GO:0090257	80	0.032
dopamine uptake	GO:0090494	4	0.032
regulation of camp biosynthetic process	GO:0030817	25	0.032	Mouse
regulation of endothelial cell migration	GO:0010594	22	0.032
regulation of cell activation	GO:0050865	289	0.032
multicellular organismal water homeostasis	GO:0050891	23	0.032
lipid homeostasis	GO:0055088	63	0.032
dopamine metabolic process	GO:0042417	23	0.031
leukocyte differentiation	GO:0002521	342	0.031	Mouse
positive regulation of hydrolase activity	GO:0051345	148	0.031
cyclic purine nucleotide metabolic process	GO:0052652	43	0.031	Mouse
positive regulation of map kinase activity	GO:0043406	84	0.031
regulation of cyclic nucleotide biosynthetic process	GO:0030802	31	0.031	Mouse
regulation of defense response	GO:0031347	233	0.031
innate immune response	GO:0045087	157	0.031
positive regulation of growth	GO:0045927	104	0.031	Mouse
regulation of cytokine secretion	GO:0050707	61	0.031
protein lipid complex remodeling	GO:0034368	6	0.031
protein kinase c activating g protein coupled receptor signaling pathway	GO:0007205	4	0.030
salivary gland development	GO:0007431	37	0.030
ensheathment of neurons	GO:0007272	76	0.030
regulation of feeding behavior	GO:0060259	3	0.030
response to ammonium ion	GO:0060359	21	0.030
gtp catabolic process	GO:0006184	143	0.030
cell cell adhesion	GO:0098609	41	0.030
positive regulation of lymphocyte activation	GO:0051251	140	0.030
regulation of fat cell differentiation	GO:0045598	81	0.030

Gcgr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.647
inherited metabolic disorder	DOID:655	0.128
diabetes mellitus	DOID:9351	0.049
type 2 diabetes mellitus	DOID:9352	0.049
carbohydrate metabolism disease	DOID:0050013	0.049
glucose metabolism disease	DOID:4194	0.049
acquired metabolic disease	DOID:0060158	0.049

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