Mus musculus

0 known processes

Smpdl3a

sphingomyelin phosphodiesterase, acid-like 3A

(Aliases: ASM3A,ASML3A,0610010C24Rik,AI529588,ASML3)

Smpdl3a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular amine metabolic processGO:0044106440.110
immune effector processGO:00022523210.082
amine metabolic processGO:0009308450.074
cellular amino acid metabolic processGO:00065201030.067
cellular ketone metabolic processGO:0042180840.055
protein processingGO:00164851630.055
protein maturationGO:00516041760.051
maintenance of locationGO:0051235890.050
oxidation reduction processGO:00551143420.050
regulation of cellular amine metabolic processGO:0033238200.048
cellular lipid metabolic processGO:00442553230.047
regulation of cellular amino acid metabolic processGO:000652150.047
regulation of apoptotic signaling pathwayGO:20012331970.045
aromatic compound catabolic processGO:00194392860.045
apoptotic signaling pathwayGO:00971903060.045
regulation of membrane potentialGO:00423911920.044
nucleoside phosphate metabolic processGO:00067533380.043
leukocyte mediated immunityGO:00024431740.042
heterocycle catabolic processGO:00467002800.041
cellular lipid catabolic processGO:0044242520.041
cation transportGO:00068123990.040
positive regulation of cell deathGO:00109422240.040
nucleobase containing small molecule metabolic processGO:00550863520.040
positive regulation of apoptotic processGO:00430652170.039
regulation of defense responseGO:00313472330.039
ras protein signal transductionGO:0007265770.039
regulation of secretionGO:00510462740.038
adaptive immune responseGO:00022501550.038
regulation of leukocyte mediated immunityGO:00027031040.037
small molecule catabolic processGO:0044282710.036
positive regulation of programmed cell deathGO:00430682180.036
nucleotide metabolic processGO:00091173320.036
negative regulation of phosphorus metabolic processGO:00105631840.035
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.035
macromolecule catabolic processGO:00090572810.035
organic hydroxy compound metabolic processGO:19016152030.034
transmembrane transportGO:00550854120.034
defense response to other organismGO:00985421970.034
regulation of cellular ketone metabolic processGO:0010565660.033
mapk cascadeGO:00001652810.033
regulation of protein maturationGO:1903317960.033
regulation of protein transportGO:00512231630.033
negative regulation of protein metabolic processGO:00512482820.032
lymphocyte mediated immunityGO:00024491390.032
regulation of cellular catabolic processGO:00313292420.031
negative regulation of phosphate metabolic processGO:00459361840.031
organophosphate biosynthetic processGO:00904071220.031
ribonucleoside metabolic processGO:00091192450.031
small gtpase mediated signal transductionGO:0007264970.030
organonitrogen compound catabolic processGO:19015652640.030
ion transmembrane transportGO:00342203610.030
inflammatory responseGO:00069542440.030
t cell activationGO:00421102890.029
regulation of hydrolase activityGO:00513362460.029
regulation of establishment of protein localizationGO:00702011810.029
lipid modificationGO:0030258650.028
glycosyl compound metabolic processGO:19016572460.028
positive regulation of cellular amino acid metabolic processGO:004576430.028
negative regulation of phosphorylationGO:00423261660.028
negative regulation of intracellular signal transductionGO:19025321670.028
cytoplasmic transportGO:00164822340.028
glycerolipid metabolic processGO:00464861220.028
regulation of transferase activityGO:00513382630.028
protein catabolic processGO:00301632210.028
regulation of secretion by cellGO:19035302490.028
regulation of mapk cascadeGO:00434082480.027
organic cyclic compound catabolic processGO:19013612950.027
spermatogenesisGO:00072832840.027
nucleoside metabolic processGO:00091162460.027
cytokine productionGO:00018163190.027
regulation of intracellular transportGO:00323861590.027
regulation of lymphocyte mediated immunityGO:0002706840.026
anatomical structure homeostasisGO:00602491450.026
cellular response to hormone stimulusGO:00328701500.025
response to lipopolysaccharideGO:00324961280.025
glycerophospholipid metabolic processGO:0006650710.025
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.025
cellular macromolecule catabolic processGO:00442652060.025
male gamete generationGO:00482322850.025
regulation of protein localizationGO:00328802310.025
purine containing compound metabolic processGO:00725213110.024
regulation of inflammatory responseGO:00507271470.024
purine nucleoside catabolic processGO:00061522050.024
monocarboxylic acid catabolic processGO:0072329270.024
negative regulation of cellular protein metabolic processGO:00322692470.024
response to organonitrogen compoundGO:00102432460.024
cellular response to cytokine stimulusGO:00713451890.024
cation transmembrane transportGO:00986552660.023
cellular ion homeostasisGO:00068731650.023
regulation of protein processingGO:0070613960.023
purine ribonucleotide catabolic processGO:00091542080.023
regulation of organelle organizationGO:00330432890.023
organophosphate catabolic processGO:00464342320.023
peptidyl amino acid modificationGO:00181933360.023
positive regulation of protein modification processGO:00314012990.023
metal ion homeostasisGO:00550651890.023
regulation of hormone levelsGO:00108172110.023
ribonucleoside triphosphate metabolic processGO:00091992200.023
regulation of kinase activityGO:00435492490.023
cellular chemical homeostasisGO:00550822150.022
response to organic cyclic compoundGO:00140701980.022
nitrogen compound transportGO:00717052710.022
positive regulation of cellular amine metabolic processGO:003324050.022
carbohydrate metabolic processGO:00059752300.022
regulation of cytokine productionGO:00018172660.022
negative regulation of molecular functionGO:00440922580.022
cellular response to lipidGO:00713961450.022
nucleotide catabolic processGO:00091662170.022
positive regulation of secretionGO:00510471300.021
regulation of lymphocyte activationGO:00512492400.021
regulation of cell cycleGO:00517262810.021
t cell mediated immunityGO:0002456500.021
extrinsic apoptotic signaling pathwayGO:00971911260.021
alcohol metabolic processGO:00060661160.021
lipid biosynthetic processGO:00086101790.021
regulation of complement activation classical pathwayGO:003045010.021
positive regulation of protein phosphorylationGO:00019342420.021
regulation of response to woundingGO:19030341890.020
transmission of nerve impulseGO:0019226760.020
striated muscle tissue developmentGO:00147062930.020
nucleoside triphosphate metabolic processGO:00091412300.020
lymphocyte proliferationGO:00466511640.020
regulation of peptidase activityGO:0052547960.020
positive regulation of protein transportGO:0051222930.020
response to oxidative stressGO:00069791230.020
regulation of proteolysisGO:00301621640.020
negative regulation of cell proliferationGO:00082852960.019
negative regulation of glycoprotein metabolic processGO:190301930.019
carbohydrate derivative catabolic processGO:19011362310.019
reactive oxygen species metabolic processGO:0072593840.019
nucleoside catabolic processGO:00091642060.019
protein ubiquitinationGO:00165671710.019
divalent metal ion transportGO:00708381720.019
positive regulation of cytokine productionGO:00018191740.019
positive regulation of secretion by cellGO:19035321140.019
ribose phosphate metabolic processGO:00196932910.019
negative regulation of protein modification processGO:00314001630.018
cell type specific apoptotic processGO:00972852680.018
intracellular protein transportGO:00068862040.018
sequestering of metal ionGO:0051238190.018
protein localization to organelleGO:00333651850.018
response to molecule of bacterial originGO:00022371430.018
carboxylic acid catabolic processGO:0046395510.018
muscle tissue developmentGO:00605373080.018
monocarboxylic acid metabolic processGO:00327871910.018
phospholipid metabolic processGO:0006644870.018
sequestering of calcium ionGO:0051208180.018
nucleoside phosphate catabolic processGO:19012922220.018
lipid localizationGO:00108761260.018
cellular divalent inorganic cation homeostasisGO:00725031270.018
compound eye developmentGO:004874910.018
proteolysis involved in cellular protein catabolic processGO:00516031470.018
leukocyte differentiationGO:00025213420.018
cellular metal ion homeostasisGO:00068751510.018
purine ribonucleoside metabolic processGO:00461282410.018
positive regulation of hydrolase activityGO:00513451480.018
ribonucleotide metabolic processGO:00092592910.018
defense response to bacteriumGO:00427421190.018
regulation of reactive oxygen species biosynthetic processGO:190342620.018
purine nucleoside metabolic processGO:00422782410.018
multicellular organismal signalingGO:0035637910.018
ossificationGO:00015032160.018
cell killingGO:0001906670.018
sensory perceptionGO:00076002450.018
regulation of cell activationGO:00508652890.018
purine nucleoside triphosphate metabolic processGO:00091442260.017
homeostasis of number of cellsGO:00488722100.017
glucose homeostasisGO:00425931280.017
regulation of homeostatic processGO:00328441820.017
cellular homeostasisGO:00197252400.017
reactive nitrogen species metabolic processGO:200105700.017
positive regulation of cellular catabolic processGO:00313311480.017
organic acid biosynthetic processGO:0016053860.017
leukocyte mediated cytotoxicityGO:0001909620.017
g protein coupled receptor signaling pathwayGO:00071862430.017
cation homeostasisGO:00550802120.017
positive regulation of defense responseGO:00313491240.017
nucleoside triphosphate catabolic processGO:00091432050.017
regulation of lymphocyte proliferationGO:00506701170.017
glycerolipid biosynthetic processGO:0045017500.017
multicellular organismal homeostasisGO:00488711640.017
ribonucleotide catabolic processGO:00092612080.017
regulation of t cell activationGO:00508631700.017
purine ribonucleoside catabolic processGO:00461302050.017
carbohydrate derivative biosynthetic processGO:19011371830.017
dna metabolic processGO:00062593030.016
negative regulation of protein phosphorylationGO:00019331260.016
purine containing compound catabolic processGO:00725232130.016
regulation of adaptive immune responseGO:0002819900.016
cellular response to organonitrogen compoundGO:00714171450.016
regulation of body fluid levelsGO:00508781620.016
muscle cell differentiationGO:00426922610.016
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.016
regulation of purine nucleotide catabolic processGO:00331211220.016
membrane organizationGO:00610242450.016
innate immune responseGO:00450871570.016
purine ribonucleoside triphosphate metabolic processGO:00092052200.016
neuronal action potentialGO:0019228540.016
t cell proliferationGO:00420981200.016
dephosphorylationGO:00163111290.016
circulatory system processGO:00030131970.016
small molecule biosynthetic processGO:00442831320.016
negative regulation of cellular amino acid metabolic processGO:004576300.016
leukocyte activation involved in immune responseGO:00023661260.015
fat cell differentiationGO:00454441600.015
purine nucleotide catabolic processGO:00061952110.015
humoral immune responseGO:0006959570.015
negative regulation of protein processingGO:0010955790.015
rho protein signal transductionGO:0007266320.015
protein modification by small protein conjugation or removalGO:00706472070.015
multi multicellular organism processGO:00447061090.015
developmental maturationGO:00217001930.015
organelle fissionGO:00482851700.015
autophagyGO:0006914450.015
ribonucleoside triphosphate catabolic processGO:00092031990.015
negative regulation of immune system processGO:00026832090.015
purine nucleotide metabolic processGO:00061633020.015
activation of immune responseGO:00022531380.015
regulation of bindingGO:00510981110.015
regulation of nucleotide catabolic processGO:00308111220.015
inorganic cation transmembrane transportGO:00986622070.015
epithelial cell proliferationGO:00506731740.015
regulation of vesicle mediated transportGO:00606271390.014
negative regulation of cellular amine metabolic processGO:003323910.014
tissue homeostasisGO:00018941150.014
regulation of cytoplasmic transportGO:19036491120.014
pyruvate transportGO:000684820.014
regulation of protein kinase activityGO:00458592320.014
cell activation involved in immune responseGO:00022631260.014
glycoprotein metabolic processGO:00091001160.014
organonitrogen compound biosynthetic processGO:19015661920.014
negative regulation of protein maturationGO:1903318790.014
response to growth factorGO:00708481980.014
leukocyte proliferationGO:00706611720.014
cellular nitrogen compound catabolic processGO:00442702800.014
response to inorganic substanceGO:0010035960.014
blood circulationGO:00080151950.014
positive regulation of mapk cascadeGO:00434101700.014
cellular calcium ion homeostasisGO:00068741190.014
carbohydrate homeostasisGO:00335001280.014
action potentialGO:0001508780.014
positive regulation of organelle organizationGO:00106381280.014
signal transduction in absence of ligandGO:0038034550.014
fertilizationGO:00095661270.014
posttranscriptional regulation of gene expressionGO:00106081550.014
peptide metabolic processGO:0006518460.014
regulation of cellular response to stressGO:00801351590.014
purine nucleoside triphosphate catabolic processGO:00091462030.014
calcium ion transportGO:00068161590.014
cellular response to thyroid hormone stimulusGO:009706710.014
lipid transportGO:0006869980.014
divalent inorganic cation homeostasisGO:00725071380.013
protein targetingGO:00066051430.013
divalent inorganic cation transportGO:00725111780.013
negative regulation of cell activationGO:00508661110.013
positive regulation of immune effector processGO:00026991070.013
reactive oxygen species biosynthetic processGO:190340980.013
calcium ion homeostasisGO:00550741270.013
positive regulation of apoptotic signaling pathwayGO:2001235950.013
exocytosisGO:00068871210.013
protein importGO:00170381010.013
production of molecular mediator of immune responseGO:00024401030.013
regulation of cell cycle processGO:00105641600.013
regulation of epithelial cell proliferationGO:00506781410.013
single fertilizationGO:0007338820.013
regulation of neuron apoptotic processGO:00435231220.013
meiotic cell cycleGO:00513211220.013
positive regulation of transferase activityGO:00513471670.013
wound healingGO:00420601570.013
cellular protein complex assemblyGO:00436231160.013
immune response regulating signaling pathwayGO:00027641250.013
peptide transportGO:00158331330.013
phosphatidylethanolamine biosynthetic processGO:000664620.013
negative regulation of cellular component organizationGO:00511291940.013
alpha beta t cell activationGO:0046631910.012
regulation of multi organism processGO:00439001110.012
hormone secretionGO:00468791280.012
phospholipid biosynthetic processGO:0008654360.012
protein secretionGO:00093061110.012
glycerophospholipid biosynthetic processGO:0046474320.012
mitochondrion organizationGO:00070051340.012
regulation of reactive oxygen species metabolic processGO:2000377400.012
regulation of nucleotide metabolic processGO:00061401690.012
regulation of neurotransmitter levelsGO:0001505870.012
cellular biogenic amine metabolic processGO:0006576280.012
response to light stimulusGO:00094161350.012
peptide hormone secretionGO:00300721090.012
positive regulation of intracellular transportGO:0032388700.012
positive regulation of protein kinase activityGO:00458601440.012
peptide secretionGO:00027901140.012
nucleocytoplasmic transportGO:00069131390.012
glycosyl compound catabolic processGO:19016582060.012
establishment of vesicle localizationGO:0051650810.012
myelinationGO:0042552740.012
regulation of system processGO:00440572000.012
nuclear divisionGO:00002801580.012
regulation of lipid metabolic processGO:00192161180.011
regulation of ossificationGO:00302781120.011
negative regulation of hydrolase activityGO:0051346710.011
hexose metabolic processGO:0019318980.011
endomembrane system organizationGO:00102561470.011
microtubule based processGO:00070172360.011
synaptic transmissionGO:00072683290.011
protein modification by small protein conjugationGO:00324461870.011
peptidyl tyrosine modificationGO:00182121450.011
positive regulation of nucleotide metabolic processGO:00459811140.011
selenium compound metabolic processGO:000188730.011
response to acid chemicalGO:00011011110.011
inorganic ion transmembrane transportGO:00986602340.011
regulation of protein catabolic processGO:00421761080.011
positive regulation of nervous system developmentGO:00519622210.011
gland developmentGO:00487323300.011
cellular response to organic cyclic compoundGO:0071407870.011
lipid catabolic processGO:0016042690.011
male courtship behaviorGO:000804920.011
positive regulation of gtp catabolic processGO:0033126850.011
locomotory behaviorGO:00076261950.011
purine ribonucleotide metabolic processGO:00091502900.011
regulation of voltage gated calcium channel activityGO:190138540.011
ear developmentGO:00435832000.011
cellular protein catabolic processGO:00442571550.011
regulation of ion transportGO:00432692150.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.011
skeletal system developmentGO:00015013560.011
stem cell differentiationGO:00488632680.011
regulation of neuron projection developmentGO:00109751690.011
spermatid differentiationGO:00485151150.011
regulation of neuron differentiationGO:00456642810.011
negative regulation of response to woundingGO:1903035770.011
cytokine metabolic processGO:0042107710.011
angiogenesisGO:00015252010.011
response to radiationGO:00093141650.011
purine ribonucleoside triphosphate catabolic processGO:00092071990.011
ensheathment of neuronsGO:0007272760.011
respiratory tube developmentGO:00303231670.011
blood coagulationGO:0007596760.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.011
response to steroid hormoneGO:0048545560.011
muscle contractionGO:00069361010.011
mitotic cell cycle processGO:19030471590.011
positive regulation of nucleotide catabolic processGO:0030813880.011
fatty acid alpha oxidationGO:000156120.011
skin developmentGO:00435882200.011
amide transportGO:00428861380.011
cellular response to growth factor stimulusGO:00713631970.011
zymogen activationGO:0031638410.011
regulation of cellular component biogenesisGO:00440871810.011
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.011
regulation of interleukin 8 secretionGO:200048220.011
organelle localizationGO:00516401790.011
regulation of leukocyte proliferationGO:00706631210.011
response to drugGO:0042493750.010
positive regulation of cell motilityGO:20001471160.010
negative regulation of complement activationGO:004591630.010
establishment of protein localization to organelleGO:00725941180.010
tissue remodelingGO:00487711020.010
coagulationGO:0050817780.010
renal system developmentGO:00720012250.010
lateral inhibitionGO:004633110.010
positive regulation of lymphocyte activationGO:00512511400.010
hematopoietic progenitor cell differentiationGO:00022441430.010
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.010
regulation of antimicrobial peptide biosynthetic processGO:000280510.010
myeloid leukocyte differentiationGO:00025731190.010
negative regulation of immune effector processGO:0002698550.010
monosaccharide metabolic processGO:00059961060.010
microtubule cytoskeleton organizationGO:00002261570.010
organic hydroxy compound transportGO:0015850930.010
urogenital system developmentGO:00016552610.010
membrane lipid metabolic processGO:0006643530.010
single organism nuclear importGO:1902593950.010
myeloid cell differentiationGO:00300992330.010
regulation of t cell proliferationGO:0042129920.010
extracellular structure organizationGO:00430621480.010
regulation of interleukin 1 alpha productionGO:003265040.010
germ cell developmentGO:00072811850.010
regulation of nucleoside metabolic processGO:00091181300.010
regulation of endopeptidase activityGO:0052548890.010

Smpdl3a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.101
inherited metabolic disorderDOID:65500.069
disease of anatomical entityDOID:700.044
nervous system diseaseDOID:86300.044
sensory system diseaseDOID:005015500.020
eye diseaseDOID:561400.020
eye and adnexa diseaseDOID:149200.020
central nervous system diseaseDOID:33100.016
retinal diseaseDOID:567900.016
retinal degenerationDOID:846600.016
acquired metabolic diseaseDOID:006015800.012
brain diseaseDOID:93600.011
lysosomal storage diseaseDOID:321100.010
neurodegenerative diseaseDOID:128900.010