IMP: Integrative Multi-species Prediction

Mus musculus

43 known processes

Cdkn2b

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

(Aliases: MTS2,AV083695,p15,p15(INK4b),p15INK4b,INK4b)

Ensembl: ENSMUSG00000073802
Entrez: 12579
UniProtKB: P55271
UniProtKB: Q549R4

Process Predictions
Disease Predictions

Cdkn2b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of immune system process	GO:0002683	209	0.308	Mouse
cell adhesion	GO:0007155	329	0.188
regulation of leukocyte differentiation	GO:1902105	159	0.173	Mouse
regulation of cell activation	GO:0050865	289	0.165	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.158
cellular amino acid metabolic process	GO:0006520	103	0.152
response to organic cyclic compound	GO:0014070	198	0.150	Rat
negative regulation of phosphate metabolic process	GO:0045936	184	0.143	Human Mouse
leukocyte differentiation	GO:0002521	342	0.129	Mouse
male gamete generation	GO:0048232	285	0.119
negative regulation of molecular function	GO:0044092	258	0.114	Human Mouse
regulation of cell cycle	GO:0051726	281	0.113
regulation of cellular amine metabolic process	GO:0033238	20	0.112
leukocyte migration	GO:0050900	124	0.110
negative regulation of lymphocyte activation	GO:0051250	91	0.105	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.105	Mouse
cellular amine metabolic process	GO:0044106	44	0.104
negative regulation of phosphorylation	GO:0042326	166	0.103	Human Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.103	Human Mouse
t cell differentiation	GO:0030217	174	0.100	Mouse
lymphocyte differentiation	GO:0030098	242	0.100	Mouse
camera type eye development	GO:0043010	266	0.099
positive regulation of programmed cell death	GO:0043068	218	0.093	Mouse
germ cell development	GO:0007281	185	0.092
cytokine production	GO:0001816	319	0.091
negative regulation of t cell activation	GO:0050868	65	0.085	Mouse
blood vessel morphogenesis	GO:0048514	285	0.084
extracellular structure organization	GO:0043062	148	0.082
regulation of cell motility	GO:2000145	236	0.081
negative regulation of protein metabolic process	GO:0051248	282	0.081	Human Mouse
negative regulation of protein maturation	GO:1903318	79	0.079	Mouse
response to molecule of bacterial origin	GO:0002237	143	0.078
regulation of cell adhesion	GO:0030155	154	0.078
placenta development	GO:0001890	140	0.076
negative regulation of cellular protein metabolic process	GO:0032269	247	0.075	Human Mouse
response to acid chemical	GO:0001101	111	0.075
negative regulation of cell activation	GO:0050866	111	0.073	Mouse
positive regulation of cell death	GO:0010942	224	0.073	Mouse
spermatogenesis	GO:0007283	284	0.072
gland development	GO:0048732	330	0.069	Mouse Rat
dna metabolic process	GO:0006259	303	0.067
negative regulation of cell cycle	GO:0045786	123	0.066
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.066	Mouse
extracellular matrix organization	GO:0030198	147	0.065
t cell activation	GO:0042110	289	0.063	Mouse
regulation of cellular catabolic process	GO:0031329	242	0.063	Mouse
cell chemotaxis	GO:0060326	81	0.063
nuclear division	GO:0000280	158	0.063
stem cell development	GO:0048864	219	0.063	Mouse
cell growth	GO:0016049	130	0.062	Mouse
response to reactive oxygen species	GO:0000302	56	0.062	Mouse
cellular ketone metabolic process	GO:0042180	84	0.062
regulation of t cell activation	GO:0050863	170	0.060	Mouse
striated muscle tissue development	GO:0014706	293	0.057
developmental maturation	GO:0021700	193	0.057
leukocyte chemotaxis	GO:0030595	69	0.057
amine metabolic process	GO:0009308	45	0.056
regulation of secretion	GO:0051046	274	0.056
response to oxidative stress	GO:0006979	123	0.056	Mouse
production of molecular mediator of immune response	GO:0002440	103	0.055
regulation of cellular amino acid metabolic process	GO:0006521	5	0.054
positive regulation of protein modification process	GO:0031401	299	0.054
organelle fission	GO:0048285	170	0.053
negative regulation of protein modification process	GO:0031400	163	0.053	Human Mouse
response to oxygen levels	GO:0070482	62	0.052
alpha beta t cell differentiation	GO:0046632	69	0.052
synaptic transmission	GO:0007268	329	0.052
regulation of defense response	GO:0031347	233	0.051
regulation of protein localization	GO:0032880	231	0.050
apoptotic signaling pathway	GO:0097190	306	0.050
protein maturation	GO:0051604	176	0.050	Mouse
nephron development	GO:0072006	109	0.049
protein modification by small protein conjugation or removal	GO:0070647	207	0.048	Mouse
respiratory system development	GO:0060541	190	0.047
regulation of organ morphogenesis	GO:2000027	144	0.047	Mouse
regulation of t cell differentiation	GO:0045580	83	0.047	Mouse
regulation of protein transport	GO:0051223	163	0.047
regionalization	GO:0003002	337	0.047
chemotaxis	GO:0006935	247	0.047
dephosphorylation	GO:0016311	129	0.046
ion transmembrane transport	GO:0034220	361	0.046
single organism cell adhesion	GO:0098602	156	0.046
muscle cell differentiation	GO:0042692	261	0.046
myeloid leukocyte migration	GO:0097529	57	0.045
organ growth	GO:0035265	117	0.045
mitotic cell cycle process	GO:1903047	159	0.045
intrinsic apoptotic signaling pathway	GO:0097193	132	0.045
single organismal cell cell adhesion	GO:0016337	131	0.044
regulation of intracellular transport	GO:0032386	159	0.044	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.044
defense response to bacterium	GO:0042742	119	0.044
regulation of proteolysis	GO:0030162	164	0.044	Mouse
establishment of protein localization to organelle	GO:0072594	118	0.043
transmembrane transport	GO:0055085	412	0.043
cellular response to dna damage stimulus	GO:0006974	207	0.043
mitotic cell cycle	GO:0000278	195	0.043
lymphocyte proliferation	GO:0046651	164	0.043	Mouse
homeostasis of number of cells	GO:0048872	210	0.043
negative regulation of protein processing	GO:0010955	79	0.042	Mouse
meiotic cell cycle	GO:0051321	122	0.042
positive regulation of neuron differentiation	GO:0045666	141	0.042
regulation of transferase activity	GO:0051338	263	0.042	Human Mouse
regulation of hydrolase activity	GO:0051336	246	0.041
modification dependent macromolecule catabolic process	GO:0043632	133	0.041	Mouse
cellular macromolecule catabolic process	GO:0044265	206	0.041	Mouse
inflammatory response	GO:0006954	244	0.041
fertilization	GO:0009566	127	0.041
modification dependent protein catabolic process	GO:0019941	133	0.041	Mouse
wound healing	GO:0042060	157	0.041
cellular response to lipid	GO:0071396	145	0.040
positive regulation of cell cycle	GO:0045787	92	0.040
adaptive immune response	GO:0002250	155	0.040
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.040
protein modification by small protein conjugation	GO:0032446	187	0.040	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	5	0.039
response to inorganic substance	GO:0010035	96	0.039	Mouse
adult behavior	GO:0030534	135	0.039
response to drug	GO:0042493	75	0.039
intracellular protein transport	GO:0006886	204	0.039
morphogenesis of a branching epithelium	GO:0061138	193	0.039
immune effector process	GO:0002252	321	0.039
sensory organ morphogenesis	GO:0090596	242	0.039
epithelial cell development	GO:0002064	159	0.038
regulation of kinase activity	GO:0043549	249	0.038	Human Mouse
response to nutrient levels	GO:0031667	109	0.038	Human
regulation of protein serine threonine kinase activity	GO:0071900	157	0.038	Human Mouse
regulation of mitotic cell cycle	GO:0007346	126	0.038
response to lipopolysaccharide	GO:0032496	128	0.038
regulation of hormone levels	GO:0010817	211	0.038
positive regulation of apoptotic process	GO:0043065	217	0.038	Mouse
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.038	Mouse
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.038	Human
response to growth factor	GO:0070848	198	0.037	Human
regulation of neuron differentiation	GO:0045664	281	0.037
macromolecule catabolic process	GO:0009057	281	0.037	Mouse
epidermis development	GO:0008544	187	0.037	Mouse
kidney epithelium development	GO:0072073	121	0.037
cation transport	GO:0006812	399	0.037
negative regulation of endopeptidase activity	GO:0010951	44	0.036
steroid metabolic process	GO:0008202	119	0.036
regulation of apoptotic signaling pathway	GO:2001233	197	0.036
cellular response to acid chemical	GO:0071229	68	0.035
regulation of cellular response to stress	GO:0080135	159	0.035
regulation of establishment of protein localization	GO:0070201	181	0.035
angiogenesis	GO:0001525	201	0.034
cellular response to inorganic substance	GO:0071241	37	0.034
regulation of protein processing	GO:0070613	96	0.034	Mouse
mesonephric tubule morphogenesis	GO:0072171	63	0.034
nitrogen compound transport	GO:0071705	271	0.034
regulation of epithelial cell proliferation	GO:0050678	141	0.034	Human Mouse
positive regulation of cell motility	GO:2000147	116	0.034
epithelial cell proliferation	GO:0050673	174	0.034	Human Mouse
amide transport	GO:0042886	138	0.034
glomerular mesangial cell development	GO:0072144	3	0.034
negative regulation of cell proliferation	GO:0008285	296	0.033	Human Mouse Rat
negative regulation of t cell differentiation	GO:0045581	23	0.033	Mouse
gastrulation	GO:0007369	116	0.033
regulation of membrane potential	GO:0042391	192	0.033
regulation of neuron projection development	GO:0010975	169	0.033
cellular response to external stimulus	GO:0071496	88	0.033	Human
positive regulation of cell activation	GO:0050867	158	0.033
heterocycle catabolic process	GO:0046700	280	0.032
segmentation	GO:0035282	93	0.032
epithelial tube morphogenesis	GO:0060562	303	0.032
chromatin organization	GO:0006325	206	0.032
protein targeting	GO:0006605	143	0.032
protein ubiquitination	GO:0016567	171	0.032	Mouse
positive regulation of lymphocyte activation	GO:0051251	140	0.032
cellular response to oxidative stress	GO:0034599	76	0.032	Mouse
positive regulation of cell migration	GO:0030335	109	0.032
leukocyte activation involved in immune response	GO:0002366	126	0.032
cellular nitrogen compound catabolic process	GO:0044270	280	0.032
aromatic compound catabolic process	GO:0019439	286	0.032
negative regulation of hydrolase activity	GO:0051346	71	0.032
response to organonitrogen compound	GO:0010243	246	0.031
hematopoietic progenitor cell differentiation	GO:0002244	143	0.031	Human
heart morphogenesis	GO:0003007	178	0.031
peptidyl amino acid modification	GO:0018193	336	0.031
digestive tract development	GO:0048565	190	0.031
positive regulation of defense response	GO:0031349	124	0.031
response to decreased oxygen levels	GO:0036293	59	0.031
cell type specific apoptotic process	GO:0097285	268	0.030	Mouse
branching morphogenesis of an epithelial tube	GO:0048754	159	0.030
ureteric bud development	GO:0001657	94	0.030
ribonucleoside catabolic process	GO:0042454	206	0.030
fat cell differentiation	GO:0045444	160	0.030
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.030	Mouse
regulation of cell cycle process	GO:0010564	160	0.030
regulation of protein maturation	GO:1903317	96	0.030	Mouse
organic cyclic compound catabolic process	GO:1901361	295	0.030
leukocyte mediated immunity	GO:0002443	174	0.030
development of primary sexual characteristics	GO:0045137	143	0.030
nephron epithelium development	GO:0072009	92	0.029
regulation of protein catabolic process	GO:0042176	108	0.029	Mouse
antimicrobial peptide biosynthetic process	GO:0002777	2	0.029
response to amino acid	GO:0043200	37	0.029
positive regulation of intracellular transport	GO:0032388	70	0.029
regulation of secretion by cell	GO:1903530	249	0.029
cytokine mediated signaling pathway	GO:0019221	115	0.029
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.028
regulation of cell substrate adhesion	GO:0010810	73	0.028
muscle tissue development	GO:0060537	308	0.028
peptidyl tyrosine phosphorylation	GO:0018108	143	0.028
antimicrobial peptide production	GO:0002775	2	0.028
g1 s transition of mitotic cell cycle	GO:0000082	57	0.028
central nervous system neuron differentiation	GO:0021953	162	0.028
regulation of embryonic development	GO:0045995	71	0.028
renal system development	GO:0072001	225	0.027
chromatin modification	GO:0016568	187	0.027
development of primary female sexual characteristics	GO:0046545	73	0.027
negative regulation of transferase activity	GO:0051348	85	0.027	Human Mouse
positive regulation of epithelial cell proliferation	GO:0050679	68	0.027
kidney morphogenesis	GO:0060993	83	0.027
regulation of protein kinase activity	GO:0045859	232	0.027	Human Mouse
carbohydrate metabolic process	GO:0005975	230	0.027
intermediate filament cytoskeleton organization	GO:0045104	26	0.027
oxidation reduction process	GO:0055114	342	0.027
mitochondrion organization	GO:0007005	134	0.027
regulation of monocyte chemotaxis	GO:0090025	3	0.027
leukocyte degranulation	GO:0043299	27	0.026
negative regulation of proteolysis	GO:0045861	74	0.026	Mouse
positive regulation of stem cell proliferation	GO:2000648	59	0.026
endomembrane system organization	GO:0010256	147	0.026
carbohydrate homeostasis	GO:0033500	128	0.026	Mouse
positive regulation of kinase activity	GO:0033674	155	0.026
skeletal muscle organ development	GO:0060538	163	0.026
cell activation involved in immune response	GO:0002263	126	0.026
positive regulation of cell adhesion	GO:0045785	80	0.026
purine nucleotide catabolic process	GO:0006195	211	0.026
positive regulation of nervous system development	GO:0051962	221	0.025
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.025
regulation of transcription from rna polymerase iii promoter	GO:0006359	2	0.025
regulation of mapk cascade	GO:0043408	248	0.025
regulation of organelle organization	GO:0033043	289	0.025
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.025
nucleobase containing small molecule metabolic process	GO:0055086	352	0.025
digestive system development	GO:0055123	200	0.025
regulation of binding	GO:0051098	111	0.025	Mouse
antibacterial peptide biosynthetic process	GO:0002780	2	0.025
regulation of response to wounding	GO:1903034	189	0.025
regulation of innate immune response	GO:0045088	91	0.025
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.025
gonad development	GO:0008406	141	0.025
leukocyte proliferation	GO:0070661	172	0.024	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.024
protein catabolic process	GO:0030163	221	0.024	Mouse
forebrain development	GO:0030900	302	0.024
regulation of muscle tissue development	GO:1901861	97	0.024
negative regulation of cellular component organization	GO:0051129	194	0.024
embryonic placenta development	GO:0001892	98	0.024
positive regulation of secretion by cell	GO:1903532	114	0.024
skeletal system morphogenesis	GO:0048705	203	0.024
regulation of cytoplasmic transport	GO:1903649	112	0.024	Mouse
myeloid leukocyte differentiation	GO:0002573	119	0.024
cellular response to cytokine stimulus	GO:0071345	189	0.024
regulation of intracellular protein transport	GO:0033157	82	0.023
intermediate filament based process	GO:0045103	27	0.023
stem cell proliferation	GO:0072089	117	0.023
response to metal ion	GO:0010038	47	0.023
compound eye development	GO:0048749	1	0.023
nucleoside triphosphate metabolic process	GO:0009141	230	0.023
glycosyl compound catabolic process	GO:1901658	206	0.023
regulation of multi organism process	GO:0043900	111	0.023
cellular response to amino acid stimulus	GO:0071230	29	0.023
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.023	Human
peptidyl tyrosine modification	GO:0018212	145	0.023
i kappab kinase nf kappab signaling	GO:0007249	85	0.023
nucleoside phosphate catabolic process	GO:1901292	222	0.023
response to radiation	GO:0009314	165	0.023
locomotory behavior	GO:0007626	195	0.023
negative regulation of protein phosphorylation	GO:0001933	126	0.023	Human Mouse
neuronal action potential	GO:0019228	54	0.023
regulation of peptidase activity	GO:0052547	96	0.022
protein localization to organelle	GO:0033365	185	0.022
peptide transport	GO:0015833	133	0.022
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.022
ribonucleotide catabolic process	GO:0009261	208	0.022
purine ribonucleotide catabolic process	GO:0009154	208	0.022
regulation of interleukin 8 secretion	GO:2000482	2	0.022
regulation of lymphocyte differentiation	GO:0045619	107	0.022	Mouse
organonitrogen compound biosynthetic process	GO:1901566	192	0.022
posttranscriptional regulation of gene expression	GO:0010608	155	0.022	Mouse
positive regulation of secretion	GO:0051047	130	0.022
positive regulation of protein kinase activity	GO:0045860	144	0.022
stem cell differentiation	GO:0048863	268	0.022	Mouse
morphogenesis of embryonic epithelium	GO:0016331	159	0.022
regulation of lymphocyte proliferation	GO:0050670	117	0.022	Mouse
protein import into nucleus	GO:0006606	95	0.022
divalent metal ion transport	GO:0070838	172	0.022
response to transforming growth factor beta	GO:0071559	88	0.022	Human
negative regulation of cytokine production	GO:0001818	84	0.021
alpha beta t cell activation	GO:0046631	91	0.021
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.021	Human
reactive oxygen species metabolic process	GO:0072593	84	0.021
skin development	GO:0043588	220	0.021	Mouse
nephron tubule development	GO:0072080	84	0.021
morphogenesis of a branching structure	GO:0001763	203	0.021
negative regulation of cellular amine metabolic process	GO:0033239	1	0.021
single fertilization	GO:0007338	82	0.021
cellular response to starvation	GO:0009267	57	0.021
regulation of cell projection organization	GO:0031344	206	0.021
meiosis i	GO:0007127	60	0.021
mapk cascade	GO:0000165	281	0.020
t cell proliferation	GO:0042098	120	0.020	Mouse
sensory perception	GO:0007600	245	0.020
mesonephros development	GO:0001823	97	0.020
endocytosis	GO:0006897	168	0.020
activation of immune response	GO:0002253	138	0.020
interleukin 8 secretion	GO:0072606	3	0.020
neural tube development	GO:0021915	160	0.020
purine ribonucleoside catabolic process	GO:0046130	205	0.020
positive regulation of leukocyte differentiation	GO:1902107	86	0.020
organonitrogen compound catabolic process	GO:1901565	264	0.020
negative regulation of leukocyte differentiation	GO:1902106	51	0.020	Mouse
somitogenesis	GO:0001756	69	0.020
spermatid differentiation	GO:0048515	115	0.020
small gtpase mediated signal transduction	GO:0007264	97	0.020
protein localization to nucleus	GO:0034504	121	0.020
lung development	GO:0030324	164	0.020
cardiac muscle tissue development	GO:0048738	130	0.020
skeletal system development	GO:0001501	356	0.020
ribonucleotide metabolic process	GO:0009259	291	0.020
b cell activation	GO:0042113	161	0.020	Mouse
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.020
regulation of organ growth	GO:0046620	61	0.020
g protein coupled receptor signaling pathway	GO:0007186	243	0.020
action potential	GO:0001508	78	0.020
negative regulation of cell motility	GO:2000146	61	0.019
cellular response to molecule of bacterial origin	GO:0071219	83	0.019
divalent inorganic cation transport	GO:0072511	178	0.019
positive regulation of hydrolase activity	GO:0051345	148	0.019
interleukin 8 production	GO:0032637	4	0.019
ubiquitin dependent protein catabolic process	GO:0006511	129	0.019	Mouse
regulation of chromosome organization	GO:0033044	83	0.019
covalent chromatin modification	GO:0016569	163	0.019
female gonad development	GO:0008585	71	0.019
purine nucleoside catabolic process	GO:0006152	205	0.019
nucleocytoplasmic transport	GO:0006913	139	0.019	Mouse
negative regulation of peptidase activity	GO:0010466	46	0.019
regulation of leukocyte proliferation	GO:0070663	121	0.019	Mouse
organophosphate catabolic process	GO:0046434	232	0.019
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.019
cellular response to organic cyclic compound	GO:0071407	87	0.019
regulation of cytokine secretion	GO:0050707	61	0.019
multicellular organism growth	GO:0035264	161	0.019
positive regulation of immune effector process	GO:0002699	107	0.019
regulation of cell growth	GO:0001558	91	0.019	Mouse
regulation of eosinophil migration	GO:2000416	2	0.019
protein processing	GO:0016485	163	0.019	Mouse
regulation of t cell proliferation	GO:0042129	92	0.019	Mouse
purine containing compound catabolic process	GO:0072523	213	0.019
dna recombination	GO:0006310	92	0.018
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway	GO:0051482	4	0.018
b cell mediated immunity	GO:0019724	71	0.018
positive regulation of interleukin 6 secretion	GO:2000778	1	0.018
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.018
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.018
polarity specification of proximal distal axis	GO:0010085	2	0.018
female gamete generation	GO:0007292	74	0.018
lymphocyte mediated immunity	GO:0002449	139	0.018
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.018	Human
epithelial tube formation	GO:0072175	130	0.018
negative regulation of growth	GO:0045926	99	0.018	Mouse
renal tubule development	GO:0061326	87	0.018
sensory perception of mechanical stimulus	GO:0050954	107	0.018
cell cycle g1 s phase transition	GO:0044843	57	0.018
antibacterial peptide production	GO:0002778	2	0.018
regulation of defense response to bacterium	GO:1900424	3	0.018
positive regulation of epidermis development	GO:0045684	13	0.018
embryonic organ morphogenesis	GO:0048562	276	0.018
cellular response to lipopolysaccharide	GO:0071222	77	0.018
embryonic epithelial tube formation	GO:0001838	130	0.018
pole plasm assembly	GO:0007315	2	0.018
defense response to other organism	GO:0098542	197	0.018
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.018
response to calcium ion	GO:0051592	20	0.018
multicellular organismal homeostasis	GO:0048871	164	0.018
cellular protein catabolic process	GO:0044257	155	0.018	Mouse
carbohydrate derivative catabolic process	GO:1901136	231	0.018
embryonic eye morphogenesis	GO:0048048	29	0.018
tube formation	GO:0035148	140	0.018
regulation of protein targeting	GO:1903533	61	0.018
immunoglobulin production	GO:0002377	73	0.017
organic hydroxy compound transport	GO:0015850	93	0.017
rna processing	GO:0006396	105	0.017
mesangial cell differentiation	GO:0072007	4	0.017
response to tumor necrosis factor	GO:0034612	26	0.017
regulation of b cell activation	GO:0050864	81	0.017	Mouse
leukocyte apoptotic process	GO:0071887	71	0.017	Mouse
developmental growth involved in morphogenesis	GO:0060560	138	0.017
regulation of inflammatory response	GO:0050727	147	0.017
spermatid development	GO:0007286	108	0.017
regulation of kidney development	GO:0090183	40	0.017
negative regulation of neuron differentiation	GO:0045665	101	0.017
smooth muscle contraction	GO:0006939	44	0.017
positive regulation of cell cycle process	GO:0090068	61	0.017
immune response activating signal transduction	GO:0002757	116	0.017
anion transport	GO:0006820	177	0.017
peptide secretion	GO:0002790	114	0.017
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.017	Human
connective tissue development	GO:0061448	179	0.017
purine nucleoside metabolic process	GO:0042278	241	0.017
bmp signaling pathway	GO:0030509	93	0.017
nephron morphogenesis	GO:0072028	69	0.017
purine ribonucleoside metabolic process	GO:0046128	241	0.017
multi multicellular organism process	GO:0044706	109	0.017
cellular response to organonitrogen compound	GO:0071417	145	0.017
dna repair	GO:0006281	107	0.017
cognition	GO:0050890	149	0.017
response to hypoxia	GO:0001666	58	0.017
hepaticobiliary system development	GO:0061008	67	0.016	Rat
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.016
positive regulation of cytokine production	GO:0001819	174	0.016
ossification	GO:0001503	216	0.016
meiotic nuclear division	GO:0007126	115	0.016
multicellular organismal signaling	GO:0035637	91	0.016
gtp metabolic process	GO:0046039	144	0.016
negative regulation of response to wounding	GO:1903035	77	0.016
nucleotide catabolic process	GO:0009166	217	0.016
ribonucleoside metabolic process	GO:0009119	245	0.016
microtubule based process	GO:0007017	236	0.016
regulation of protein secretion	GO:0050708	82	0.016
nephron epithelium morphogenesis	GO:0072088	68	0.016
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.016
actin cytoskeleton organization	GO:0030036	220	0.016
regulation of endopeptidase activity	GO:0052548	89	0.016
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.016
regulation of synaptic plasticity	GO:0048167	87	0.016
signal transduction by p53 class mediator	GO:0072331	51	0.016
positive regulation of protein transport	GO:0051222	93	0.016
purine nucleotide metabolic process	GO:0006163	302	0.016
positive regulation of eosinophil migration	GO:2000418	2	0.016
transcription from rna polymerase iii promoter	GO:0006383	3	0.016
protein secretion	GO:0009306	111	0.016
nucleoside phosphate metabolic process	GO:0006753	338	0.016
neural crest cell development	GO:0014032	48	0.016
microtubule cytoskeleton organization	GO:0000226	157	0.016
stem cell maintenance	GO:0019827	130	0.016	Mouse
somatic sex determination	GO:0018993	2	0.016
nephrogenic mesenchyme development	GO:0072076	3	0.016
negative regulation of kinase activity	GO:0033673	81	0.016	Human Mouse
cell substrate adhesion	GO:0031589	130	0.016
gtp catabolic process	GO:0006184	143	0.015
cellular response to fibroblast growth factor stimulus	GO:0044344	47	0.015
nucleoside metabolic process	GO:0009116	246	0.015
response to extracellular stimulus	GO:0009991	127	0.015	Human
somite development	GO:0061053	81	0.015
endocrine system development	GO:0035270	98	0.015
single organism nuclear import	GO:1902593	95	0.015
leukocyte mediated cytotoxicity	GO:0001909	62	0.015
limb development	GO:0060173	166	0.015
regulation of ion transport	GO:0043269	215	0.015
regulation of action potential	GO:0098900	4	0.015
response to steroid hormone	GO:0048545	56	0.015
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.015
ras protein signal transduction	GO:0007265	77	0.015
neutrophil mediated immunity	GO:0002446	19	0.015
mammary gland alveolus development	GO:0060749	22	0.015
regulation of angiogenesis	GO:0045765	81	0.015
exocytosis	GO:0006887	121	0.015
response to retinoic acid	GO:0032526	56	0.015
regulation of alpha beta t cell differentiation	GO:0046637	35	0.015
mitotic nuclear division	GO:0007067	48	0.015
regulation of interleukin 8 production	GO:0032677	3	0.015
regulation of lipid metabolic process	GO:0019216	118	0.015
regulation of stem cell proliferation	GO:0072091	78	0.015
glycosyl compound metabolic process	GO:1901657	246	0.015
organelle localization	GO:0051640	179	0.015
regulation of nucleotide metabolic process	GO:0006140	169	0.015
positive regulation of cytokine secretion	GO:0050715	41	0.015
myotube differentiation	GO:0014902	105	0.015
adult locomotory behavior	GO:0008344	91	0.015
positive regulation of organelle organization	GO:0010638	128	0.015
hindbrain development	GO:0030902	128	0.015
glucose homeostasis	GO:0042593	128	0.015	Mouse
glomerular mesangial cell differentiation	GO:0072008	3	0.015
cellular response to growth factor stimulus	GO:0071363	197	0.015	Human
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	34	0.015
positive regulation of t helper 1 cell differentiation	GO:0045627	4	0.015
mrna metabolic process	GO:0016071	84	0.015
positive regulation of protein phosphorylation	GO:0001934	242	0.015
cellular response to biotic stimulus	GO:0071216	92	0.015
regulation of cellular component biogenesis	GO:0044087	181	0.015
telencephalon development	GO:0021537	186	0.015
sprouting angiogenesis	GO:0002040	26	0.015
cellular response to extracellular stimulus	GO:0031668	81	0.015	Human
midgut development	GO:0007494	4	0.014
alcohol metabolic process	GO:0006066	116	0.014
positive regulation of cell development	GO:0010720	237	0.014	Mouse
cellular response to calcium ion	GO:0071277	14	0.014
myeloid cell differentiation	GO:0030099	233	0.014	Human
positive regulation of mitotic cell cycle	GO:0045931	41	0.014
regulation of vasculature development	GO:1901342	88	0.014
response to vitamin a	GO:0033189	1	0.014

Cdkn2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.045
disease of anatomical entity	DOID:7	0.045
eye and adnexa disease	DOID:1492	0.022
sensory system disease	DOID:0050155	0.022
eye disease	DOID:5614	0.017

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