Mus musculus

0 known processes

Klhl34

kelch-like 34 (Drosophila)

(Aliases: Gm388)

Klhl34 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cation transmembrane transportGO:00986552660.115
ion transmembrane transportGO:00342203610.112
male gamete generationGO:00482322850.097
transmembrane transportGO:00550854120.085
inorganic cation transmembrane transportGO:00986622070.076
inorganic ion transmembrane transportGO:00986602340.076
g protein coupled receptor signaling pathwayGO:00071862430.073
muscle tissue developmentGO:00605373080.073
skeletal system developmentGO:00015013560.069
nitrogen compound transportGO:00717052710.063
cellular amino acid metabolic processGO:00065201030.058
spermatogenesisGO:00072832840.053
cellular amine metabolic processGO:0044106440.048
regulation of cellular ketone metabolic processGO:0010565660.045
negative regulation of intracellular signal transductionGO:19025321670.043
cation transportGO:00068123990.041
cell adhesionGO:00071553290.040
kidney developmentGO:00018222130.040
cellular response to lipidGO:00713961450.039
nucleotide metabolic processGO:00091173320.038
positive regulation of cell developmentGO:00107202370.036
striated muscle tissue developmentGO:00147062930.036
regulation of cellular amino acid metabolic processGO:000652150.036
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.035
cellular ketone metabolic processGO:0042180840.035
apoptotic signaling pathwayGO:00971903060.035
regulation of system processGO:00440572000.035
small gtpase mediated signal transductionGO:0007264970.035
anion transportGO:00068201770.035
regulation of ion transmembrane transportGO:00347651190.035
response to organonitrogen compoundGO:00102432460.035
ras protein signal transductionGO:0007265770.035
muscle cell differentiationGO:00426922610.035
regulation of secretion by cellGO:19035302490.034
regulation of membrane potentialGO:00423911920.034
metal ion homeostasisGO:00550651890.034
cell type specific apoptotic processGO:00972852680.033
gland developmentGO:00487323300.033
positive regulation of cellular amino acid metabolic processGO:004576430.033
regulation of cellular amine metabolic processGO:0033238200.033
cellular response to growth factor stimulusGO:00713631970.033
regulation of neuron differentiationGO:00456642810.032
camera type eye developmentGO:00430102660.032
regulation of secretionGO:00510462740.031
cell fate commitmentGO:00451652100.031
purine containing compound metabolic processGO:00725213110.031
amine metabolic processGO:0009308450.031
sensory perceptionGO:00076002450.031
lymphocyte differentiationGO:00300982420.031
purine nucleotide metabolic processGO:00061633020.031
cellular chemical homeostasisGO:00550822150.031
respiratory tube developmentGO:00303231670.030
blood vessel morphogenesisGO:00485142850.030
organic acid transportGO:00158491010.030
urogenital system developmentGO:00016552610.030
rho protein signal transductionGO:0007266320.030
organic cyclic compound catabolic processGO:19013612950.030
positive regulation of protein modification processGO:00314012990.029
regulation of lymphocyte activationGO:00512492400.029
organic anion transportGO:00157111370.029
retina development in camera type eyeGO:00600411190.029
renal system developmentGO:00720012250.028
nucleoside phosphate metabolic processGO:00067533380.028
epithelial tube morphogenesisGO:00605623030.028
transmission of nerve impulseGO:0019226760.028
hormone secretionGO:00468791280.028
negative regulation of cell proliferationGO:00082852960.027
skin developmentGO:00435882200.027
fat cell differentiationGO:00454441600.027
regulation of hormone levelsGO:00108172110.027
sensory organ morphogenesisGO:00905962420.027
connective tissue developmentGO:00614481790.027
cellular homeostasisGO:00197252400.027
ribonucleotide metabolic processGO:00092592910.027
exocytosisGO:00068871210.026
cellular lipid metabolic processGO:00442553230.026
aromatic compound catabolic processGO:00194392860.026
carbohydrate metabolic processGO:00059752300.026
carboxylic acid transportGO:00469421000.026
cellular response to molecule of bacterial originGO:0071219830.025
ossificationGO:00015032160.025
wound healingGO:00420601570.025
multicellular organismal signalingGO:0035637910.025
glucose homeostasisGO:00425931280.025
respiratory system developmentGO:00605411900.025
muscle adaptationGO:0043500390.025
myotube differentiationGO:00149021050.024
methionine transportGO:001582110.024
positive regulation of cellular amine metabolic processGO:003324050.024
cytoplasmic transportGO:00164822340.024
adult behaviorGO:00305341350.024
negative regulation of immune system processGO:00026832090.024
peptide transportGO:00158331330.024
synaptic transmissionGO:00072683290.024
morphogenesis of a branching structureGO:00017632030.023
cellular response to organonitrogen compoundGO:00714171450.023
t cell activationGO:00421102890.023
placenta developmentGO:00018901400.023
leukocyte differentiationGO:00025213420.023
regulation of apoptotic signaling pathwayGO:20012331970.023
wnt signaling pathwayGO:00160551880.023
protein catabolic processGO:00301632210.023
b cell activationGO:00421131610.023
regionalizationGO:00030023370.023
response to growth factorGO:00708481980.023
ribose phosphate metabolic processGO:00196932910.022
nucleoside metabolic processGO:00091162460.022
myeloid cell differentiationGO:00300992330.022
regulation of ion transportGO:00432692150.022
locomotory behaviorGO:00076261950.022
cation homeostasisGO:00550802120.022
amide transportGO:00428861380.022
developmental cell growthGO:0048588840.022
cellular metal ion homeostasisGO:00068751510.022
muscle system processGO:00030121410.022
peptidyl amino acid modificationGO:00181933360.022
regulation of protein kinase activityGO:00458592320.022
regulation of kinase activityGO:00435492490.022
regulation of body fluid levelsGO:00508781620.021
epithelial cell developmentGO:00020641590.021
regulation of transferase activityGO:00513382630.021
germ cell developmentGO:00072811850.021
organ growthGO:00352651170.021
regulation of nucleoside metabolic processGO:00091181300.021
multicellular organismal homeostasisGO:00488711640.021
mitotic cell cycleGO:00002781950.021
epidermis developmentGO:00085441870.021
regulation of leukocyte differentiationGO:19021051590.021
heart morphogenesisGO:00030071780.021
morphogenesis of a branching epitheliumGO:00611381930.021
digestive tract morphogenesisGO:00485461470.021
cellular nitrogen compound catabolic processGO:00442702800.021
mapk cascadeGO:00001652810.020
neuron apoptotic processGO:00514021420.020
response to organic cyclic compoundGO:00140701980.020
response to acid chemicalGO:00011011110.020
cellular response to biotic stimulusGO:0071216920.020
lateral inhibitionGO:004633110.020
purine ribonucleoside triphosphate metabolic processGO:00092052200.020
embryonic organ morphogenesisGO:00485622760.020
regulation of cell migrationGO:00303342190.020
cartilage developmentGO:00512161400.020
purine ribonucleotide metabolic processGO:00091502900.020
conditioned taste aversionGO:000166140.020
positive regulation of protein phosphorylationGO:00019342420.020
lung developmentGO:00303241640.020
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.020
nucleoside triphosphate metabolic processGO:00091412300.020
regulation of transmembrane transportGO:00347621280.020
macromolecule catabolic processGO:00090572810.020
angiogenesisGO:00015252010.020
regulation of cellular catabolic processGO:00313292420.020
cellular response to amino acid stimulusGO:0071230290.020
carbohydrate homeostasisGO:00335001280.020
positive regulation of kinase activityGO:00336741550.020
digestive system developmentGO:00551232000.020
homeostasis of number of cellsGO:00488722100.019
regulation of homeostatic processGO:00328441820.019
monocarboxylic acid metabolic processGO:00327871910.019
posttranscriptional regulation of gene expressionGO:00106081550.019
purine ribonucleotide catabolic processGO:00091542080.019
regulation of hydrolase activityGO:00513362460.019
multi multicellular organism processGO:00447061090.019
insulin secretionGO:0030073890.019
purine nucleoside triphosphate metabolic processGO:00091442260.019
regulation of cell motilityGO:20001452360.019
cell growth involved in cardiac muscle cell developmentGO:006104930.019
regulation of reproductive processGO:2000241660.019
organonitrogen compound catabolic processGO:19015652640.019
calcium ion homeostasisGO:00550741270.019
response to lipopolysaccharideGO:00324961280.018
regulation of cell cycleGO:00517262810.018
organelle fissionGO:00482851700.018
digestive tract developmentGO:00485651900.018
regulation of cytokine productionGO:00018172660.018
positive regulation of nervous system developmentGO:00519622210.018
regulation of fat cell differentiationGO:0045598810.018
protein maturationGO:00516041760.018
ribonucleoside triphosphate metabolic processGO:00091992200.018
multicellular organismal response to stressGO:0033555620.018
microtubule based processGO:00070172360.018
neural tube formationGO:00018411080.018
c4 dicarboxylate transportGO:001574030.018
regulation of mapk cascadeGO:00434082480.018
positive regulation of secretionGO:00510471300.018
positive regulation of apoptotic processGO:00430652170.018
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.018
positive regulation of programmed cell deathGO:00430682180.017
floor plate morphogenesisGO:003350530.017
reactive oxygen species metabolic processGO:0072593840.017
learning or memoryGO:00076111480.017
regulation of organelle organizationGO:00330432890.017
forebrain developmentGO:00309003020.017
mitotic cell cycle processGO:19030471590.017
muscle cell developmentGO:00550011330.017
organonitrogen compound biosynthetic processGO:19015661920.017
cardiocyte differentiationGO:0035051870.017
glycosyl compound metabolic processGO:19016572460.017
epithelial tube formationGO:00721751300.017
divalent inorganic cation transportGO:00725111780.017
striated muscle cell developmentGO:00550021250.017
regulation of neuron apoptotic processGO:00435231220.017
regulation of anatomical structure sizeGO:00900661780.017
cell divisionGO:00513011200.017
regulation of muscle system processGO:0090257800.017
regulation of establishment of protein localizationGO:00702011810.017
anatomical structure homeostasisGO:00602491450.017
negative regulation of phosphate metabolic processGO:00459361840.017
hematopoietic progenitor cell differentiationGO:00022441430.017
divalent inorganic cation homeostasisGO:00725071380.017
leukocyte apoptotic processGO:0071887710.017
immune effector processGO:00022523210.017
regulation of striated muscle cell differentiationGO:0051153810.017
positive regulation of secretion by cellGO:19035321140.017
organic hydroxy compound metabolic processGO:19016152030.017
mesenchyme developmentGO:00604851520.017
regulation of protein localizationGO:00328802310.016
negative regulation of molecular functionGO:00440922580.016
positive regulation of hydrolase activityGO:00513451480.016
skeletal system morphogenesisGO:00487052030.016
nucleobase containing small molecule metabolic processGO:00550863520.016
cell recognitionGO:0008037830.016
regulation of muscle tissue developmentGO:1901861970.016
cognitionGO:00508901490.016
positive regulation of cell deathGO:00109422240.016
nucleoside phosphate catabolic processGO:19012922220.016
regulation of cell activationGO:00508652890.016
cytokine productionGO:00018163190.016
regulation of neuron projection developmentGO:00109751690.016
ribonucleoside metabolic processGO:00091192450.016
stem cell developmentGO:00488642190.016
regulation of bmp signaling pathwayGO:0030510600.016
protein ubiquitinationGO:00165671710.016
embryonic epithelial tube formationGO:00018381300.016
carbohydrate derivative catabolic processGO:19011362310.016
inflammatory responseGO:00069542440.016
immune response regulating signaling pathwayGO:00027641250.016
extracellular matrix organizationGO:00301981470.016
regulation of purine nucleotide metabolic processGO:19005421690.016
organelle assemblyGO:00709251770.016
regulation of cell adhesionGO:00301551540.016
negative regulation of cellular protein metabolic processGO:00322692470.016
spermatid differentiationGO:00485151150.016
response to amino acidGO:0043200370.016
fertilizationGO:00095661270.016
response to light stimulusGO:00094161350.016
regulation of cell projection organizationGO:00313442060.016
neuron deathGO:00709971540.015
cellular protein catabolic processGO:00442571550.015
membrane organizationGO:00610242450.015
leukocyte migrationGO:00509001240.015
amino acid transportGO:0006865610.015
dendrite developmentGO:00163581150.015
ear developmentGO:00435832000.015
chemotaxisGO:00069352470.015
ribonucleoside triphosphate catabolic processGO:00092031990.015
multicellular organism growthGO:00352641610.015
negative regulation of cell developmentGO:00107211690.015
neuronal action potentialGO:0019228540.015
regulation of ras protein signal transductionGO:00465781140.015
regulation of cellular component biogenesisGO:00440871810.015
defense response to other organismGO:00985421970.015
ribonucleoside catabolic processGO:00424542060.015
developmental maturationGO:00217001930.015
skeletal muscle organ developmentGO:00605381630.015
spermatid developmentGO:00072861080.015
limb developmentGO:00601731660.015
positive regulation of cell motilityGO:20001471160.015
epithelial cell proliferationGO:00506731740.015
purine ribonucleoside catabolic processGO:00461302050.015
pallium developmentGO:00215431200.015
peptide hormone secretionGO:00300721090.015
physiological cardiac muscle hypertrophyGO:000330130.015
response to radiationGO:00093141650.015
cellular response to acid chemicalGO:0071229680.015
anion transmembrane transportGO:0098656710.015
purine nucleoside metabolic processGO:00422782410.015
regulation of ossificationGO:00302781120.015
cellular response to lipopolysaccharideGO:0071222770.015
response to molecule of bacterial originGO:00022371430.015
activation of immune responseGO:00022531380.015
cellular response to hormone stimulusGO:00328701500.015
cellular ion homeostasisGO:00068731650.015
neural tube developmentGO:00219151600.015
negative regulation of protein metabolic processGO:00512482820.014
positive regulation of nucleotide catabolic processGO:0030813880.014
chromatin organizationGO:00063252060.014
bmp signaling pathwayGO:0030509930.014
neural precursor cell proliferationGO:00613511210.014
olfactory learningGO:000835520.014
purine ribonucleoside metabolic processGO:00461282410.014
ear morphogenesisGO:00424711180.014
negative regulation of cell motilityGO:2000146610.014
positive regulation of transferase activityGO:00513471670.014
regulation of peptide transportGO:0090087910.014
positive regulation of neuron differentiationGO:00456661410.014
peptide secretionGO:00027901140.014
regulation of cell cycle processGO:00105641600.014
central nervous system neuron differentiationGO:00219531620.014
muscle contractionGO:00069361010.014
regulation of nucleotide metabolic processGO:00061401690.014
cellular response to dna damage stimulusGO:00069742070.014
negative regulation of phosphorylationGO:00423261660.014
reactive oxygen species biosynthetic processGO:190340980.014
regulation of proteolysisGO:00301621640.014
purine nucleoside catabolic processGO:00061522050.014
lipid localizationGO:00108761260.014
tube closureGO:0060606910.014
organophosphate catabolic processGO:00464342320.014
cell maturationGO:00484691270.014
purine nucleoside triphosphate catabolic processGO:00091462030.014
intrinsic apoptotic signaling pathwayGO:00971931320.014
purine ribonucleoside triphosphate catabolic processGO:00092071990.014
oxidation reduction processGO:00551143420.014
cardiac chamber developmentGO:00032051080.014
cardiac muscle cell differentiationGO:0055007690.014
b cell differentiationGO:0030183780.014
modification dependent protein catabolic processGO:00199411330.014
cellular carbohydrate metabolic processGO:00442621190.014
regulation of peptide hormone secretionGO:0090276750.013
intracellular protein transportGO:00068862040.013
innate immune responseGO:00450871570.013
tendon cell differentiationGO:003599040.013
cardiac cell developmentGO:0055006410.013
regulation of protein serine threonine kinase activityGO:00719001570.013
nucleoside catabolic processGO:00091642060.013
tissue remodelingGO:00487711020.013
response to extracellular stimulusGO:00099911270.013
nucleoside triphosphate catabolic processGO:00091432050.013
small molecule biosynthetic processGO:00442831320.013
response to insulinGO:00328681000.013
cardiac ventricle developmentGO:0003231830.013
adult locomotory behaviorGO:0008344910.013
regulation of organ growthGO:0046620610.013
tissue homeostasisGO:00018941150.013
regulation of wnt signaling pathwayGO:00301111230.013
appendage morphogenesisGO:00351071490.013
nucleocytoplasmic transportGO:00069131390.013
regulation of vesicle mediated transportGO:00606271390.013
protein localization to organelleGO:00333651850.013
leukocyte proliferationGO:00706611720.013
protein modification by small protein conjugation or removalGO:00706472070.013
regulation of reactive oxygen species metabolic processGO:2000377400.013
nuclear divisionGO:00002801580.013
regulation of lymphocyte differentiationGO:00456191070.013
protein processingGO:00164851630.013
regulation of cell substrate adhesionGO:0010810730.013
peptidyl tyrosine modificationGO:00182121450.013
regulation of reactive oxygen species biosynthetic processGO:190342620.013
immune response activating cell surface receptor signaling pathwayGO:0002429720.013
calcium ion dependent exocytosisGO:0017156350.013
regulation of map kinase activityGO:00434051200.013
purine containing compound catabolic processGO:00725232130.013
divalent metal ion transportGO:00708381720.013
generation of precursor metabolites and energyGO:00060911030.012
purine nucleotide catabolic processGO:00061952110.012
protein secretionGO:00093061110.012
potassium ion transportGO:0006813520.012
blastocyst developmentGO:0001824800.012
cellular macromolecule catabolic processGO:00442652060.012
developmental growth involved in morphogenesisGO:00605601380.012
negative regulation of phosphorus metabolic processGO:00105631840.012
cell growthGO:00160491300.012
negative regulation of neuron differentiationGO:00456651010.012
chromatin modificationGO:00165681870.012
circulatory system processGO:00030131970.012
sequestering of calcium ionGO:0051208180.012
cell substrate adhesionGO:00315891300.012
cerebellum developmentGO:0021549770.012
regulation of protein transportGO:00512231630.012
reactive nitrogen species metabolic processGO:200105700.012
transition metal ion homeostasisGO:0055076540.012
action potentialGO:0001508780.012
blood circulationGO:00080151950.012
axonogenesisGO:00074092740.012
regulation of mitotic cell cycleGO:00073461260.012
regulation of hormone secretionGO:0046883880.012
glial cell differentiationGO:00100011310.012
ribonucleotide catabolic processGO:00092612080.012
morphogenesis of embryonic epitheliumGO:00163311590.012
heart processGO:0003015940.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.012
heart contractionGO:0060047930.012
actin cytoskeleton organizationGO:00300362200.012
embryonic placenta developmentGO:0001892980.012
single fertilizationGO:0007338820.012
cell matrix adhesionGO:0007160680.012
heterocycle catabolic processGO:00467002800.012
nuclear transportGO:00511691390.012
cellular divalent inorganic cation homeostasisGO:00725031270.012
limb morphogenesisGO:00351081490.012
defense response to bacteriumGO:00427421190.012
single organism cell adhesionGO:00986021560.012
negative regulation of synapse assemblyGO:005196430.012
primary neural tube formationGO:0014020950.012
glycerolipid metabolic processGO:00464861220.012
neuron neuron synaptic transmissionGO:0007270690.012
regulation of actin filament based processGO:0032970990.012
bone developmentGO:00603481200.012
regulation of heart growthGO:0060420310.012
regulation of peptidase activityGO:0052547960.012
regulation of cytoplasmic transportGO:19036491120.012
regulation of multi organism processGO:00439001110.011
regulation of exocytosisGO:0017157610.011
negative regulation of endothelial cell migrationGO:001059640.011
negative regulation of bmp signaling pathwayGO:0030514350.011
response to peptideGO:19016521360.011
ubiquitin dependent protein catabolic processGO:00065111290.011
positive regulation of protein transportGO:0051222930.011
immune response regulating cell surface receptor signaling pathwayGO:0002768800.011
sequestering of metal ionGO:0051238190.011
bone morphogenesisGO:0060349780.011
response to nutrient levelsGO:00316671090.011
myeloid leukocyte differentiationGO:00025731190.011
extracellular structure organizationGO:00430621480.011
ureteric bud developmentGO:0001657940.011
negative regulation of neuron deathGO:1901215980.011
positive regulation of purine nucleotide metabolic processGO:19005441140.011
sodium ion transportGO:0006814730.011
regulation of protein complex assemblyGO:0043254830.011
microtubule cytoskeleton organizationGO:00002261570.011
carbohydrate derivative biosynthetic processGO:19011371830.011
cardiac chamber morphogenesisGO:0003206930.011
positive regulation of protein serine threonine kinase activityGO:00719021060.011
neural tube closureGO:0001843900.011
nucleotide catabolic processGO:00091662170.011
positive regulation of cell migrationGO:00303351090.011
glycosyl compound catabolic processGO:19016582060.011
stem cell proliferationGO:00720891170.011
photoreceptor cell differentiationGO:0046530520.011
response to transforming growth factor betaGO:0071559880.011
mesonephros developmentGO:0001823970.011
positive regulation of growthGO:00459271040.011
cellular response to cytokine stimulusGO:00713451890.011
stem cell differentiationGO:00488632680.011
regulation of nucleotide catabolic processGO:00308111220.011
kidney epithelium developmentGO:00720731210.011
positive regulation of mapk cascadeGO:00434101700.011
positive regulation of cellular catabolic processGO:00313311480.011
alanine transportGO:003232840.011
regulation of peptide secretionGO:0002791770.011
cellular response to transforming growth factor beta stimulusGO:0071560880.011
regulation of cell cycle phase transitionGO:1901987770.011
regulation of neuron deathGO:19012141340.011
regulation of intracellular transportGO:00323861590.011
gliogenesisGO:00420631410.011
positive regulation of lymphocyte activationGO:00512511400.011
methylationGO:00322591340.011
mesonephric epithelium developmentGO:0072163940.011
sensory perception of soundGO:0007605970.011
lymphocyte homeostasisGO:0002260640.011
regulation of organ morphogenesisGO:20000271440.011
t cell differentiation in thymusGO:0033077770.011
regulation of metal ion transportGO:00109591060.010
response to inorganic substanceGO:0010035960.010
cellular calcium ion homeostasisGO:00068741190.010
sodium ion transmembrane transportGO:0035725490.010
negative regulation of growthGO:0045926990.010
regulation of response to woundingGO:19030341890.010
branching morphogenesis of an epithelial tubeGO:00487541590.010
positive regulation of immune effector processGO:00026991070.010
calcium ion transportGO:00068161590.010
tube formationGO:00351481400.010
cellular response to extracellular stimulusGO:0031668810.010
negative regulation of cell activationGO:00508661110.010
regulation of heart contractionGO:0008016770.010
polarity specification of proximal distal axisGO:001008520.010
negative regulation of nervous system developmentGO:00519611560.010
regulation of purine nucleotide catabolic processGO:00331211220.010
negative regulation of protein phosphorylationGO:00019331260.010
regulation of cellular carbohydrate metabolic processGO:0010675750.010
gtp catabolic processGO:00061841430.010
regulation of synaptic growth at neuromuscular junctionGO:000858240.010
purine ribonucleoside monophosphate metabolic processGO:0009167800.010
protein targetingGO:00066051430.010
lipid transportGO:0006869980.010
regulation of myotube differentiationGO:0010830620.010
determination of left right symmetryGO:0007368800.010
ensheathment of neuronsGO:0007272760.010
gene silencingGO:0016458380.010
striated muscle hypertrophyGO:0014897240.010
regulation of myeloid cell differentiationGO:0045637960.010
cell chemotaxisGO:0060326810.010
positive regulation of cell cycleGO:0045787920.010
regulation of cardiac muscle tissue growthGO:0055021260.010
positive regulation of reactive oxygen species biosynthetic processGO:190342820.010
positive regulation of leukocyte differentiationGO:1902107860.010
negative regulation of cellular amino acid metabolic processGO:004576300.010
interleukin 8 productionGO:003263740.010
leukocyte mediated immunityGO:00024431740.010

Klhl34 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.024
disease of anatomical entityDOID:700.024
central nervous system diseaseDOID:33100.016
musculoskeletal system diseaseDOID:1700.012
cardiovascular system diseaseDOID:128700.011