IMP: Integrative Multi-species Prediction

Mus musculus

5 known processes

Matn4

matrilin 4

(Aliases: matrilin-4)

Ensembl: ENSMUSG00000016995
Entrez: 17183
UniProtKB: O89029
UniProtKB: F2Z3U4

Process Predictions
Disease Predictions

Matn4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
skeletal system development	GO:0001501	356	0.745	Mouse
axonogenesis	GO:0007409	274	0.627	Mouse
skeletal system morphogenesis	GO:0048705	203	0.580	Mouse
neuron projection extension	GO:1990138	64	0.516
ossification	GO:0001503	216	0.495	Mouse
chondrocyte differentiation	GO:0002062	72	0.472	Mouse
telencephalon development	GO:0021537	186	0.465
chondrocyte development	GO:0002063	24	0.459	Mouse
respiratory tube development	GO:0030323	167	0.458
extracellular matrix organization	GO:0030198	147	0.445
negative regulation of cell development	GO:0010721	169	0.409
cell substrate adhesion	GO:0031589	130	0.404
negative regulation of neuron projection development	GO:0010977	50	0.386
negative regulation of axon extension	GO:0030517	19	0.351
endochondral bone morphogenesis	GO:0060350	50	0.350	Mouse
lung development	GO:0030324	164	0.341
positive regulation of programmed cell death	GO:0043068	218	0.335
sensory perception	GO:0007600	245	0.326
placenta development	GO:0001890	140	0.315
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.313
regulation of body fluid levels	GO:0050878	162	0.309
connective tissue development	GO:0061448	179	0.307	Mouse
bone morphogenesis	GO:0060349	78	0.303	Mouse
cell growth	GO:0016049	130	0.291
pallium development	GO:0021543	120	0.290
regulation of neuron projection development	GO:0010975	169	0.283
bone development	GO:0060348	120	0.281	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.280
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.279
rho protein signal transduction	GO:0007266	32	0.279
chemotaxis	GO:0006935	247	0.258	Mouse
neuron migration	GO:0001764	122	0.258	Mouse
cell adhesion	GO:0007155	329	0.258
blood vessel morphogenesis	GO:0048514	285	0.244
positive regulation of protein modification process	GO:0031401	299	0.240
epithelial tube formation	GO:0072175	130	0.239
synaptic transmission	GO:0007268	329	0.232
mapk cascade	GO:0000165	281	0.230
positive regulation of cell development	GO:0010720	237	0.229
ras protein signal transduction	GO:0007265	77	0.228
cartilage development	GO:0051216	140	0.225	Mouse
regulation of cell substrate adhesion	GO:0010810	73	0.223
coagulation	GO:0050817	78	0.219
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.213
cardiac septum morphogenesis	GO:0060411	46	0.207
forebrain development	GO:0030900	302	0.207
central nervous system neuron differentiation	GO:0021953	162	0.205
mesonephric tubule development	GO:0072164	94	0.205
blood coagulation	GO:0007596	76	0.203
embryonic epithelial tube formation	GO:0001838	130	0.203
regulation of chemotaxis	GO:0050920	53	0.203
cation homeostasis	GO:0055080	212	0.203
camera type eye development	GO:0043010	266	0.201
epithelial cell development	GO:0002064	159	0.201
regulation of protein kinase activity	GO:0045859	232	0.197
cardiac septum development	GO:0003279	59	0.197
cellular response to growth factor stimulus	GO:0071363	197	0.197
appendage morphogenesis	GO:0035107	149	0.196
negative regulation of cell growth	GO:0030308	44	0.192
regulation of axon extension	GO:0030516	43	0.191
regulation of kinase activity	GO:0043549	249	0.189
regulation of cell motility	GO:2000145	236	0.189
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.188
developmental growth involved in morphogenesis	GO:0060560	138	0.186	Mouse
striated muscle tissue development	GO:0014706	293	0.185
digestive tract development	GO:0048565	190	0.185
heart morphogenesis	GO:0003007	178	0.180
negative regulation of growth	GO:0045926	99	0.179
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.177
developmental cell growth	GO:0048588	84	0.175
cell type specific apoptotic process	GO:0097285	268	0.175
wound healing	GO:0042060	157	0.172
regulation of cell projection organization	GO:0031344	206	0.168
guanosine containing compound catabolic process	GO:1901069	144	0.165
cellular homeostasis	GO:0019725	240	0.163
tube formation	GO:0035148	140	0.163
aromatic compound catabolic process	GO:0019439	286	0.163
epithelial tube morphogenesis	GO:0060562	303	0.162
regulation of response to wounding	GO:1903034	189	0.162
negative regulation of axon guidance	GO:1902668	8	0.160
metanephros morphogenesis	GO:0003338	24	0.159
regulation of chondrocyte differentiation	GO:0032330	33	0.159
skeletal muscle organ development	GO:0060538	163	0.158
digestive system development	GO:0055123	200	0.158
heart contraction	GO:0060047	93	0.156
kidney epithelium development	GO:0072073	121	0.156
positive regulation of cellular amine metabolic process	GO:0033240	5	0.150
neuron projection guidance	GO:0097485	141	0.150	Mouse
regulation of wound healing	GO:0061041	40	0.150
lymphocyte differentiation	GO:0030098	242	0.149
developmental maturation	GO:0021700	193	0.148
regulation of neuron differentiation	GO:0045664	281	0.148
regulation of cellular amino acid metabolic process	GO:0006521	5	0.147
regulation of ion transport	GO:0043269	215	0.146
heterocycle catabolic process	GO:0046700	280	0.145
negative regulation of cell projection organization	GO:0031345	56	0.144
muscle cell differentiation	GO:0042692	261	0.143
regulation of cellular ketone metabolic process	GO:0010565	66	0.143
positive regulation of transferase activity	GO:0051347	167	0.141
maintenance of cell number	GO:0098727	3	0.140
response to growth factor	GO:0070848	198	0.140
cardiac chamber development	GO:0003205	108	0.140
neural tube formation	GO:0001841	108	0.137
regulation of transferase activity	GO:0051338	263	0.135
inorganic cation transmembrane transport	GO:0098662	207	0.135
mesonephros development	GO:0001823	97	0.134
purine ribonucleotide catabolic process	GO:0009154	208	0.134
satellite cell activation involved in skeletal muscle regeneration	GO:0014901	3	0.130
glycoprotein metabolic process	GO:0009100	116	0.128
ear morphogenesis	GO:0042471	118	0.125
cellular metal ion homeostasis	GO:0006875	151	0.125
mesenchymal cell differentiation	GO:0048762	107	0.125
hemostasis	GO:0007599	78	0.124
negative regulation of cellular component organization	GO:0051129	194	0.124
organophosphate catabolic process	GO:0046434	232	0.124
positive regulation of protein phosphorylation	GO:0001934	242	0.123
regulation of cellular amine metabolic process	GO:0033238	20	0.122
regulation of cell adhesion	GO:0030155	154	0.121
morphogenesis of embryonic epithelium	GO:0016331	159	0.121
membrane organization	GO:0061024	245	0.120
transmembrane transport	GO:0055085	412	0.120
regulation of protein localization	GO:0032880	231	0.119
regulation of cartilage development	GO:0061035	44	0.119
cellular nitrogen compound catabolic process	GO:0044270	280	0.119
regulation of cellular component biogenesis	GO:0044087	181	0.118
regulation of anatomical structure size	GO:0090066	178	0.118
positive regulation of cell adhesion	GO:0045785	80	0.117
axon guidance	GO:0007411	141	0.116	Mouse
positive regulation of cell death	GO:0010942	224	0.116
action potential	GO:0001508	78	0.116
bone mineralization	GO:0030282	54	0.116	Mouse
nucleoside triphosphate catabolic process	GO:0009143	205	0.115
postganglionic parasympathetic nervous system development	GO:0021784	2	0.114
regulation of neural precursor cell proliferation	GO:2000177	70	0.114
ear development	GO:0043583	200	0.114
cation transmembrane transport	GO:0098655	266	0.112
platelet activation	GO:0030168	40	0.112
negative regulation of cell morphogenesis involved in differentiation	GO:0010771	48	0.110
ventricular septum development	GO:0003281	42	0.110
positive regulation of apoptotic process	GO:0043065	217	0.110
outflow tract morphogenesis	GO:0003151	53	0.110
purine nucleotide catabolic process	GO:0006195	211	0.109
renal vesicle induction	GO:0072034	3	0.108
regulation of cellular component size	GO:0032535	121	0.108
regulation of extent of cell growth	GO:0061387	52	0.108
locomotory behavior	GO:0007626	195	0.108
regionalization	GO:0003002	337	0.107
apoptotic signaling pathway	GO:0097190	306	0.107
positive regulation of protein transport	GO:0051222	93	0.107
regulation of canonical wnt signaling pathway	GO:0060828	82	0.105
nucleoside triphosphate metabolic process	GO:0009141	230	0.105
positive regulation of protein kinase activity	GO:0045860	144	0.105
urogenital system development	GO:0001655	261	0.105
peptidyl amino acid modification	GO:0018193	336	0.105
regulation of mapk cascade	GO:0043408	248	0.104
cellular amine metabolic process	GO:0044106	44	0.104
mesodermal cell migration	GO:0008078	4	0.103
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.103
muscle tissue development	GO:0060537	308	0.102
ribonucleoside catabolic process	GO:0042454	206	0.102
regulation of endocytosis	GO:0030100	69	0.101
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	GO:0014834	3	0.100
extracellular structure organization	GO:0043062	148	0.100
mesonephric epithelium development	GO:0072163	94	0.099
muscular septum morphogenesis	GO:0003150	4	0.099
cation transport	GO:0006812	399	0.099
regulation of cellular response to stress	GO:0080135	159	0.098
cerebral cortex development	GO:0021987	86	0.098
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.098
gland development	GO:0048732	330	0.098
tissue remodeling	GO:0048771	102	0.097
cardiac chamber morphogenesis	GO:0003206	93	0.097
small gtpase mediated signal transduction	GO:0007264	97	0.096
cerebellum development	GO:0021549	77	0.096
nucleoside metabolic process	GO:0009116	246	0.096
regulation of protein serine threonine kinase activity	GO:0071900	157	0.096
carbohydrate derivative catabolic process	GO:1901136	231	0.095
metal ion homeostasis	GO:0055065	189	0.095
blood circulation	GO:0008015	195	0.094
wnt signaling pathway	GO:0016055	188	0.094
positive regulation of cell migration	GO:0030335	109	0.094
actin cytoskeleton organization	GO:0030036	220	0.094
response to organic cyclic compound	GO:0014070	198	0.094
regulation of cell cell adhesion mediated by cadherin	GO:2000047	2	0.093
cell maturation	GO:0048469	127	0.093
regulation of secretion	GO:0051046	274	0.093
neural tube closure	GO:0001843	90	0.092
neural tube development	GO:0021915	160	0.092
positive regulation of cell substrate adhesion	GO:0010811	47	0.092
anatomical structure homeostasis	GO:0060249	145	0.091
autonomic nervous system development	GO:0048483	43	0.091
cellular chemical homeostasis	GO:0055082	215	0.090
skin development	GO:0043588	220	0.090
purine nucleotide metabolic process	GO:0006163	302	0.089
response to acid chemical	GO:0001101	111	0.089
positive regulation of nervous system development	GO:0051962	221	0.088
gonad development	GO:0008406	141	0.087
proteoglycan metabolic process	GO:0006029	38	0.087
g protein coupled receptor signaling pathway	GO:0007186	243	0.086
regulation of heart contraction	GO:0008016	77	0.086
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.085
nucleoside phosphate catabolic process	GO:1901292	222	0.085
response to organonitrogen compound	GO:0010243	246	0.085
positive regulation of cell projection organization	GO:0031346	95	0.084
synapse organization	GO:0050808	125	0.084
negative regulation of cell motility	GO:2000146	61	0.084
muscle system process	GO:0003012	141	0.083
metanephric loop of henle development	GO:0072236	4	0.083
embryonic placenta development	GO:0001892	98	0.083
regulation of cell activation	GO:0050865	289	0.083
ribonucleotide metabolic process	GO:0009259	291	0.083
positive regulation of mapk cascade	GO:0043410	170	0.083
positive regulation of secretion by cell	GO:1903532	114	0.081
t cell activation	GO:0042110	289	0.081
regulation of cell migration	GO:0030334	219	0.080
regulation of cell size	GO:0008361	72	0.080
gastrulation	GO:0007369	116	0.080
nucleobase containing small molecule metabolic process	GO:0055086	352	0.079
sympathetic nervous system development	GO:0048485	22	0.079
purine nucleoside catabolic process	GO:0006152	205	0.079
neuron projection extension involved in neuron projection guidance	GO:1902284	14	0.079
nerve development	GO:0021675	67	0.079
limb bud formation	GO:0060174	10	0.078
positive regulation of kinase activity	GO:0033674	155	0.078
negative regulation of neuron differentiation	GO:0045665	101	0.078
sensory perception of mechanical stimulus	GO:0050954	107	0.077
divalent inorganic cation transport	GO:0072511	178	0.077
regulation of cell growth	GO:0001558	91	0.077
sensory organ morphogenesis	GO:0090596	242	0.076
positive regulation of ras gtpase activity	GO:0032320	65	0.076
sensory perception of chemical stimulus	GO:0007606	51	0.076
regulation of map kinase activity	GO:0043405	120	0.076
positive regulation of protein secretion	GO:0050714	52	0.076
extrinsic apoptotic signaling pathway	GO:0097191	126	0.076
calcium ion homeostasis	GO:0055074	127	0.075
cardiac ventricle development	GO:0003231	83	0.075
respiratory system development	GO:0060541	190	0.075
positive regulation of gtpase activity	GO:0043547	85	0.075
regeneration	GO:0031099	38	0.074	Mouse
regulation of secretion by cell	GO:1903530	249	0.074
single organism cell adhesion	GO:0098602	156	0.074
renal system development	GO:0072001	225	0.074
purine nucleoside metabolic process	GO:0042278	241	0.074
myotube differentiation	GO:0014902	105	0.074
positive regulation of proteolysis	GO:0045862	85	0.073
b cell activation	GO:0042113	161	0.073
metencephalon development	GO:0022037	89	0.072
epithelial cell proliferation	GO:0050673	174	0.072
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.072
thyroid stimulating hormone secreting cell differentiation	GO:0060129	4	0.071
metanephros development	GO:0001656	79	0.071
hindbrain development	GO:0030902	128	0.070
kidney development	GO:0001822	213	0.070
positive regulation of map kinase activity	GO:0043406	84	0.070
morphogenesis of a branching structure	GO:0001763	203	0.070
regulation of organ morphogenesis	GO:2000027	144	0.070
hepaticobiliary system development	GO:0061008	67	0.069
cellular response to external stimulus	GO:0071496	88	0.069
stem cell proliferation	GO:0072089	117	0.069
positive regulation of neuron projection development	GO:0010976	79	0.069
ameboidal type cell migration	GO:0001667	128	0.068
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.068
bmp signaling pathway	GO:0030509	93	0.068
cellular ion homeostasis	GO:0006873	165	0.068
wnt signaling pathway calcium modulating pathway	GO:0007223	2	0.067
positive regulation of cell cell adhesion mediated by cadherin	GO:2000049	2	0.067
positive regulation of neuron differentiation	GO:0045666	141	0.067
regulation of establishment of protein localization	GO:0070201	181	0.066
trunk neural crest cell migration	GO:0036484	4	0.066
regulation of bone mineralization	GO:0030500	31	0.066	Mouse
regulation of wnt signaling pathway	GO:0030111	123	0.066
protein localization to membrane	GO:0072657	108	0.066
peptidyl tyrosine phosphorylation	GO:0018108	143	0.066
spermatogenesis	GO:0007283	284	0.065
purine ribonucleoside catabolic process	GO:0046130	205	0.065
astrocyte fate commitment	GO:0060018	4	0.065
non canonical wnt signaling pathway	GO:0035567	33	0.064
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.064
ribose phosphate metabolic process	GO:0019693	291	0.064
glycosyl compound metabolic process	GO:1901657	246	0.063
muscle cell development	GO:0055001	133	0.063
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway	GO:0051482	4	0.063
bone trabecula morphogenesis	GO:0061430	12	0.063
nucleoside phosphate metabolic process	GO:0006753	338	0.062
negative regulation of phosphorus metabolic process	GO:0010563	184	0.062
t cell differentiation	GO:0030217	174	0.062
cellular ketone metabolic process	GO:0042180	84	0.062
organ growth	GO:0035265	117	0.062	Mouse
regulation of organelle organization	GO:0033043	289	0.062
cardiac ventricle morphogenesis	GO:0003208	50	0.062
placenta blood vessel development	GO:0060674	31	0.062
limb development	GO:0060173	166	0.062
single organismal cell cell adhesion	GO:0016337	131	0.062
septum primum development	GO:0003284	4	0.062
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.061
cytoplasmic transport	GO:0016482	234	0.061
nucleoside catabolic process	GO:0009164	206	0.061
striated muscle cell development	GO:0055002	125	0.061
ribonucleoside metabolic process	GO:0009119	245	0.061
glycosyl compound catabolic process	GO:1901658	206	0.060
liver development	GO:0001889	66	0.060
primary neural tube formation	GO:0014020	95	0.060
ventricular septum morphogenesis	GO:0060412	27	0.060
regulation of systemic arterial blood pressure	GO:0003073	61	0.060
macromolecule catabolic process	GO:0009057	281	0.060
neuron apoptotic process	GO:0051402	142	0.060
stress activated protein kinase signaling cascade	GO:0031098	81	0.060
sensory perception of sound	GO:0007605	97	0.059
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.059
somatotropin secreting cell differentiation	GO:0060126	4	0.059
multicellular organismal signaling	GO:0035637	91	0.059
regulation of tube size	GO:0035150	57	0.059
regulation of protein transport	GO:0051223	163	0.059
protein catabolic process	GO:0030163	221	0.059
forebrain generation of neurons	GO:0021872	63	0.058
progesterone secretion	GO:0042701	1	0.058
central nervous system morphogenesis	GO:0021551	2	0.058
skeletal muscle fiber development	GO:0048741	58	0.058
purine containing compound metabolic process	GO:0072521	311	0.058
organonitrogen compound catabolic process	GO:1901565	264	0.058
mesonephric tubule morphogenesis	GO:0072171	63	0.058
determination of heart left right asymmetry	GO:0061371	48	0.058
cellular lipid metabolic process	GO:0044255	323	0.058
regulation of axon guidance	GO:1902667	13	0.058
angiogenesis	GO:0001525	201	0.057
nephron tubule morphogenesis	GO:0072078	68	0.057
cognition	GO:0050890	149	0.057
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.057
inorganic ion transmembrane transport	GO:0098660	234	0.057
molting cycle	GO:0042303	90	0.056
regulation of protein secretion	GO:0050708	82	0.056
cellular component assembly involved in morphogenesis	GO:0010927	139	0.056
neuronal action potential	GO:0019228	54	0.056
synapse assembly	GO:0007416	56	0.055
labyrinthine layer blood vessel development	GO:0060716	21	0.055
circulatory system process	GO:0003013	197	0.055
oviduct development	GO:0060066	3	0.055
multicellular organism growth	GO:0035264	161	0.055
cartilage development involved in endochondral bone morphogenesis	GO:0060351	24	0.055	Mouse
cardiac muscle tissue development	GO:0048738	130	0.055
positive regulation of hydrolase activity	GO:0051345	148	0.055
limbic system development	GO:0021761	72	0.054
neural crest cell differentiation	GO:0014033	54	0.054
hair follicle development	GO:0001942	85	0.053
inflammatory response	GO:0006954	244	0.053
establishment of planar polarity involved in neural tube closure	GO:0090177	15	0.053
branching morphogenesis of an epithelial tube	GO:0048754	159	0.053
planar cell polarity pathway involved in pericardium morphogenesis	GO:0061354	2	0.053
inner ear morphogenesis	GO:0042472	101	0.052
muscle tissue morphogenesis	GO:0060415	53	0.052
regulation of cytokine production	GO:0001817	266	0.052
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.052
regulation of ossification	GO:0030278	112	0.052	Mouse
hindbrain tangential cell migration	GO:0021934	2	0.052
regulation of ras gtpase activity	GO:0032318	88	0.051
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.051
limb morphogenesis	GO:0035108	149	0.051
trabecula morphogenesis	GO:0061383	40	0.051
mesoderm formation	GO:0001707	62	0.051
gtp metabolic process	GO:0046039	144	0.051
regulation of renin secretion into blood stream	GO:1900133	4	0.051
endomembrane system organization	GO:0010256	147	0.051
wnt signaling pathway involved in forebrain neuroblast division	GO:0021874	2	0.051
amine metabolic process	GO:0009308	45	0.051
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.050
regulation of muscle tissue development	GO:1901861	97	0.050
multicellular organismal homeostasis	GO:0048871	164	0.050
regulation of blood vessel size	GO:0050880	56	0.050
purine ribonucleotide metabolic process	GO:0009150	290	0.050
digestive tract morphogenesis	GO:0048546	147	0.050
axon extension involved in axon guidance	GO:0048846	14	0.050
negative regulation of response to wounding	GO:1903035	77	0.050
response to inorganic substance	GO:0010035	96	0.049
divalent metal ion transport	GO:0070838	172	0.049
response to amino acid	GO:0043200	37	0.049
positive regulation of cytokine production	GO:0001819	174	0.049
cellular calcium ion homeostasis	GO:0006874	119	0.049
embryonic appendage morphogenesis	GO:0035113	126	0.049
endodermal cell fate specification	GO:0001714	4	0.049
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.048
nephron epithelium development	GO:0072009	92	0.048
embryonic organ morphogenesis	GO:0048562	276	0.048
positive regulation of neuron apoptotic process	GO:0043525	25	0.048
embryonic heart tube development	GO:0035050	65	0.048
ensheathment of neurons	GO:0007272	76	0.048
planar cell polarity pathway involved in ventricular septum morphogenesis	GO:0061348	2	0.048
negative regulation of cell proliferation	GO:0008285	296	0.048
establishment of tissue polarity	GO:0007164	28	0.048
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.048
peripheral nervous system development	GO:0007422	53	0.048
renal tubule morphogenesis	GO:0061333	72	0.048
negative regulation of gastrulation	GO:2000542	3	0.048
glial cell differentiation	GO:0010001	131	0.047
establishment of planar polarity	GO:0001736	28	0.047
calcium ion transport	GO:0006816	159	0.047
ureteric bud development	GO:0001657	94	0.047
ion transmembrane transport	GO:0034220	361	0.047
forebrain neuron differentiation	GO:0021879	52	0.047
regulation of satellite cell activation involved in skeletal muscle regeneration	GO:0014717	3	0.047
cell matrix adhesion	GO:0007160	68	0.046
cell chemotaxis	GO:0060326	81	0.046
salivary gland development	GO:0007431	37	0.046
non canonical wnt signaling pathway involved in heart development	GO:0061341	3	0.046
regulation of system process	GO:0044057	200	0.046
semaphorin plexin signaling pathway	GO:0071526	21	0.046
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.045
hypophysis morphogenesis	GO:0048850	3	0.045
regulation of nucleoside metabolic process	GO:0009118	130	0.045
regulation of hormone secretion	GO:0046883	88	0.045
cranial nerve development	GO:0021545	41	0.045
purine ribonucleoside metabolic process	GO:0046128	241	0.045
guanosine containing compound metabolic process	GO:1901068	144	0.045
negative regulation of synapse assembly	GO:0051964	3	0.045
cell communication by chemical coupling	GO:0010643	2	0.045
regulation of ventricular cardiac muscle cell membrane depolarization	GO:0060373	2	0.045
peptidyl tyrosine modification	GO:0018212	145	0.044
tissue homeostasis	GO:0001894	115	0.044
somitogenesis	GO:0001756	69	0.044
regulation of cellular catabolic process	GO:0031329	242	0.044
embryonic placenta morphogenesis	GO:0060669	25	0.044
regulation of transmembrane transport	GO:0034762	128	0.044
purine containing compound catabolic process	GO:0072523	213	0.044
positive regulation of gtp catabolic process	GO:0033126	85	0.044
intestinal epithelial structure maintenance	GO:0060729	4	0.044
regulation of rho protein signal transduction	GO:0035023	71	0.044
central nervous system neuron development	GO:0021954	67	0.043
tissue migration	GO:0090130	68	0.043
regulation of neuron apoptotic process	GO:0043523	122	0.043
regulation of establishment of planar polarity	GO:0090175	28	0.043
determination of left right symmetry	GO:0007368	80	0.043
immune effector process	GO:0002252	321	0.043
appendage development	GO:0048736	166	0.043
cellular response to lipid	GO:0071396	145	0.043
regulation of vesicle mediated transport	GO:0060627	139	0.043
labyrinthine layer development	GO:0060711	49	0.043
smoothened signaling pathway	GO:0007224	105	0.043
nucleotide catabolic process	GO:0009166	217	0.042
regulation of peptide transport	GO:0090087	91	0.042
regulation of mitotic cell cycle	GO:0007346	126	0.042
leukocyte migration	GO:0050900	124	0.042
activation of mapk activity	GO:0000187	59	0.041
negative regulation of cell activation	GO:0050866	111	0.041
regulation of anagen	GO:0051884	1	0.041
canonical wnt signaling pathway involved in regulation of cell proliferation	GO:0044340	3	0.041
regulation of biomineral tissue development	GO:0070167	33	0.041	Mouse
hematopoietic progenitor cell differentiation	GO:0002244	143	0.041
morphogenesis of a polarized epithelium	GO:0001738	37	0.041
embryonic digit morphogenesis	GO:0042733	56	0.041
regulation of inflammatory response	GO:0050727	147	0.041
hair cycle	GO:0042633	90	0.041
myoblast differentiation	GO:0045445	52	0.040
innate immune response	GO:0045087	157	0.040
cell recognition	GO:0008037	83	0.040
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.040
trabecula formation	GO:0060343	24	0.040
transmission of nerve impulse	GO:0019226	76	0.039
lateral sprouting involved in mammary gland duct morphogenesis	GO:0060599	2	0.039
regulation of metal ion transport	GO:0010959	106	0.039
positive regulation of peptidase activity	GO:0010952	49	0.039
regulation of hydrolase activity	GO:0051336	246	0.039
organic cyclic compound catabolic process	GO:1901361	295	0.039
muscle contraction	GO:0006936	101	0.039
positive regulation of stem cell proliferation	GO:2000648	59	0.039
nitrogen compound transport	GO:0071705	271	0.039
myotube cell development	GO:0014904	60	0.039
regulation of ras protein signal transduction	GO:0046578	114	0.039
wnt signaling pathway planar cell polarity pathway	GO:0060071	27	0.038
response to endoplasmic reticulum stress	GO:0034976	53	0.038
positive regulation of organelle organization	GO:0010638	128	0.038
cell aggregation	GO:0098743	18	0.038
response to extracellular stimulus	GO:0009991	127	0.038
male gamete generation	GO:0048232	285	0.037
tertiary branching involved in mammary gland duct morphogenesis	GO:0060748	3	0.037
planar cell polarity pathway involved in neural tube closure	GO:0090179	14	0.037
endocytosis	GO:0006897	168	0.037
cartilage condensation	GO:0001502	18	0.037
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	61	0.037
cell differentiation involved in embryonic placenta development	GO:0060706	26	0.037
nephron tubule development	GO:0072080	84	0.037
response to light stimulus	GO:0009416	135	0.037
lung alveolus development	GO:0048286	45	0.037
muscle fiber development	GO:0048747	76	0.037
negative regulation of chemotaxis	GO:0050922	11	0.037
nephron development	GO:0072006	109	0.037
insulin secretion	GO:0030073	89	0.037
interleukin 8 production	GO:0032637	4	0.036
negative regulation of cell adhesion	GO:0007162	45	0.036
canonical wnt signaling pathway	GO:0060070	130	0.036
regulation of homeostatic process	GO:0032844	182	0.036
prostate gland development	GO:0030850	48	0.036
segmentation	GO:0035282	93	0.036
negative chemotaxis	GO:0050919	14	0.036

Matn4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.101
musculoskeletal system disease	DOID:17	0.101
connective tissue disease	DOID:65	0.101
nervous system disease	DOID:863	0.078

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