Mus musculus

2 known processes

Smpd2

sphingomyelin phosphodiesterase 2, neutral

(Aliases: AW108287,nSMase,nSMase1)

Smpd2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular lipid metabolic processGO:00442553230.320
monocarboxylic acid metabolic processGO:00327871910.166
regulation of cellular ketone metabolic processGO:0010565660.150
cellular ketone metabolic processGO:0042180840.124
regulation of cellular amino acid metabolic processGO:000652150.108
oxidation reduction processGO:00551143420.089
cellular amino acid metabolic processGO:00065201030.088
cellular lipid catabolic processGO:0044242520.085
amine metabolic processGO:0009308450.079
cytoplasmic transportGO:00164822340.075
vacuole organizationGO:0007033380.068
regulation of cellular amine metabolic processGO:0033238200.064
cation transportGO:00068123990.064
steroid metabolic processGO:00082021190.061
regulation of synaptic growth at neuromuscular junctionGO:000858240.055
membrane organizationGO:00610242450.052
mapk cascadeGO:00001652810.052
glycerolipid metabolic processGO:00464861220.051
cellular response to extracellular stimulusGO:0031668810.050
peptidyl amino acid modificationGO:00181933360.050
carboxylic acid catabolic processGO:0046395510.049
negative regulation of cell proliferationGO:00082852960.049
nitrogen compound transportGO:00717052710.048
skin developmentGO:00435882200.047
response to extracellular stimulusGO:00099911270.047
regulation of vacuole organizationGO:004408840.047
endocytosisGO:00068971680.046
regulation of hormone levelsGO:00108172110.046
transmembrane transportGO:00550854120.046
regulation of mapk cascadeGO:00434082480.046
maintenance of locationGO:0051235890.046
nucleoside phosphate metabolic processGO:00067533380.044
nucleotide metabolic processGO:00091173320.043
organic acid catabolic processGO:0016054510.041
cytokine productionGO:00018163190.041
cellular response to starvationGO:0009267570.041
regulation of organelle organizationGO:00330432890.041
purine nucleotide metabolic processGO:00061633020.041
regulation of cellular catabolic processGO:00313292420.039
lipid localizationGO:00108761260.038
lipid biosynthetic processGO:00086101790.038
small molecule catabolic processGO:0044282710.038
monocarboxylic acid catabolic processGO:0072329270.037
cellular amine metabolic processGO:0044106440.036
protein targetingGO:00066051430.036
response to nutrient levelsGO:00316671090.036
nucleobase containing small molecule metabolic processGO:00550863520.035
response to light stimulusGO:00094161350.035
regulation of cholesterol metabolic processGO:0090181140.035
organic hydroxy compound metabolic processGO:19016152030.034
peptide hormone secretionGO:00300721090.034
positive regulation of cellular amino acid metabolic processGO:004576430.034
protein maturationGO:00516041760.032
macroautophagyGO:0016236210.032
response to starvationGO:0042594650.032
regulation of cytokine productionGO:00018172660.032
organonitrogen compound catabolic processGO:19015652640.032
ribonucleotide metabolic processGO:00092592910.032
skeletal system developmentGO:00015013560.031
purine containing compound metabolic processGO:00725213110.030
proteolysis involved in cellular protein catabolic processGO:00516031470.030
fatty acid oxidationGO:0019395280.030
positive regulation of protein modification processGO:00314012990.029
transmission of nerve impulseGO:0019226760.029
ubiquitin dependent protein catabolic processGO:00065111290.028
protein localization to peroxisomeGO:007266240.028
protein localization to organelleGO:00333651850.027
negative regulation of protein metabolic processGO:00512482820.027
regulation of membrane potentialGO:00423911920.027
nucleoside metabolic processGO:00091162460.026
regulation of cellular component biogenesisGO:00440871810.026
organonitrogen compound biosynthetic processGO:19015661920.026
positive regulation of protein phosphorylationGO:00019342420.026
cellular component assembly involved in morphogenesisGO:00109271390.026
organophosphate biosynthetic processGO:00904071220.025
protein processingGO:00164851630.025
cellular response to nutrient levelsGO:0031669640.025
multicellular organism growthGO:00352641610.025
positive regulation of cellular amine metabolic processGO:003324050.025
lateral inhibitionGO:004633110.025
covalent chromatin modificationGO:00165691630.025
histone modificationGO:00165701590.024
glycosyl compound metabolic processGO:19016572460.024
germ cell developmentGO:00072811850.024
intracellular protein transportGO:00068862040.024
negative regulation of nervous system developmentGO:00519611560.024
aromatic compound catabolic processGO:00194392860.024
lipid modificationGO:0030258650.024
muscle cell differentiationGO:00426922610.024
organic cyclic compound catabolic processGO:19013612950.024
fatty acid metabolic processGO:00066311210.024
regulation of t cell proliferationGO:0042129920.024
establishment of protein localization to organelleGO:00725941180.024
protein importGO:00170381010.024
regulation of cell activationGO:00508652890.023
negative regulation of phosphorylationGO:00423261660.023
regulation of neuron differentiationGO:00456642810.023
myeloid leukocyte differentiationGO:00025731190.023
negative regulation of cellular protein metabolic processGO:00322692470.023
hematopoietic progenitor cell differentiationGO:00022441430.023
regulation of secretionGO:00510462740.023
nucleoside triphosphate metabolic processGO:00091412300.023
regulation of lipid metabolic processGO:00192161180.023
response to growth factorGO:00708481980.023
nucleotide catabolic processGO:00091662170.023
cofactor metabolic processGO:0051186800.022
microtubule based processGO:00070172360.022
t cell activationGO:00421102890.022
regulation of cellular response to stressGO:00801351590.022
negative regulation of phosphate metabolic processGO:00459361840.022
blood vessel morphogenesisGO:00485142850.022
response to radiationGO:00093141650.022
glycosyl compound catabolic processGO:19016582060.022
rhythmic processGO:00485111740.021
purine ribonucleotide metabolic processGO:00091502900.021
neutral lipid metabolic processGO:0006638570.021
metal ion homeostasisGO:00550651890.021
locomotory behaviorGO:00076261950.021
cellular response to external stimulusGO:0071496880.021
epidermis developmentGO:00085441870.021
smoothened signaling pathwayGO:00072241050.021
chromatin modificationGO:00165681870.021
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.021
cellular nitrogen compound catabolic processGO:00442702800.020
organelle assemblyGO:00709251770.020
nucleoside phosphate catabolic processGO:19012922220.020
negative regulation of cellular amino acid metabolic processGO:004576300.020
carbohydrate derivative catabolic processGO:19011362310.020
regulation of transferase activityGO:00513382630.020
sulfur compound metabolic processGO:00067901000.020
purine nucleoside metabolic processGO:00422782410.020
positive regulation of programmed cell deathGO:00430682180.020
negative regulation of cytokine productionGO:0001818840.020
protein catabolic processGO:00301632210.020
negative regulation of cell developmentGO:00107211690.020
lipid catabolic processGO:0016042690.020
cellular response to growth factor stimulusGO:00713631970.020
cell adhesionGO:00071553290.020
purine ribonucleoside metabolic processGO:00461282410.020
regulation of cell motilityGO:20001452360.020
modification dependent protein catabolic processGO:00199411330.019
regulation of secretion by cellGO:19035302490.019
purine nucleoside triphosphate metabolic processGO:00091442260.019
negative regulation of synapse assemblyGO:005196430.019
peroxisomal transportGO:004357440.019
ribonucleoside triphosphate catabolic processGO:00092031990.019
nuclear transportGO:00511691390.019
proteasomal protein catabolic processGO:0010498980.019
central nervous system neuron differentiationGO:00219531620.019
chemotaxisGO:00069352470.019
purine containing compound catabolic processGO:00725232130.019
regulation of vesicle mediated transportGO:00606271390.019
protein import into peroxisome matrixGO:001655830.019
cellular macromolecule catabolic processGO:00442652060.019
neuronal action potentialGO:0019228540.018
response to organonitrogen compoundGO:00102432460.018
regulation of bindingGO:00510981110.018
cytokine biosynthetic processGO:0042089680.018
leukocyte differentiationGO:00025213420.018
endomembrane system organizationGO:00102561470.018
cation transmembrane transportGO:00986552660.018
innate immune responseGO:00450871570.018
peptide secretionGO:00027901140.018
regulation of protein serine threonine kinase activityGO:00719001570.018
striated muscle tissue developmentGO:00147062930.018
inorganic cation transmembrane transportGO:00986622070.018
cellular divalent inorganic cation homeostasisGO:00725031270.017
organic acid biosynthetic processGO:0016053860.017
sensory perceptionGO:00076002450.017
posttranscriptional regulation of gene expressionGO:00106081550.017
forebrain developmentGO:00309003020.017
small molecule biosynthetic processGO:00442831320.017
heterocycle catabolic processGO:00467002800.017
negative regulation of intracellular signal transductionGO:19025321670.017
urogenital system developmentGO:00016552610.017
multicellular organismal homeostasisGO:00488711640.017
ameboidal type cell migrationGO:00016671280.017
ribonucleotide catabolic processGO:00092612080.017
regulation of lymphocyte proliferationGO:00506701170.017
alpha amino acid metabolic processGO:1901605590.017
regulation of kinase activityGO:00435492490.017
embryonic organ morphogenesisGO:00485622760.016
nucleoside catabolic processGO:00091642060.016
negative regulation of cellular amine metabolic processGO:003323910.016
protein ubiquitinationGO:00165671710.016
methylationGO:00322591340.016
response to drugGO:0042493750.016
response to organic cyclic compoundGO:00140701980.016
inorganic ion transmembrane transportGO:00986602340.016
ossificationGO:00015032160.016
stem cell developmentGO:00488642190.016
spermatogenesisGO:00072832840.016
positive regulation of cell activationGO:00508671580.016
positive regulation of kinase activityGO:00336741550.016
protein modification by small protein conjugationGO:00324461870.016
positive regulation of cell developmentGO:00107202370.016
telencephalon developmentGO:00215371860.016
positive regulation of mapk cascadeGO:00434101700.016
very long chain fatty acid catabolic processGO:004276020.016
regulation of hydrolase activityGO:00513362460.016
regulation of t cell activationGO:00508631700.016
regulation of endocytosisGO:0030100690.016
regulation of protein kinase activityGO:00458592320.016
reactive nitrogen species metabolic processGO:200105700.016
carbohydrate homeostasisGO:00335001280.016
cardiac chamber morphogenesisGO:0003206930.016
regulation of hormone secretionGO:0046883880.015
multicellular organismal signalingGO:0035637910.015
fatty acid beta oxidationGO:0006635160.015
negative regulation of neuron projection developmentGO:0010977500.015
very long chain fatty acid metabolic processGO:000003880.015
kidney developmentGO:00018222130.015
regulation of map kinase activityGO:00434051200.015
regulation of protein maturationGO:1903317960.015
purine nucleotide catabolic processGO:00061952110.015
regulation of cell cycleGO:00517262810.015
amide transportGO:00428861380.015
anion transportGO:00068201770.015
organophosphate catabolic processGO:00464342320.015
cognitionGO:00508901490.015
inflammatory responseGO:00069542440.015
cation homeostasisGO:00550802120.015
neuron migrationGO:00017641220.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.015
muscle tissue developmentGO:00605373080.015
cellular response to lipidGO:00713961450.015
ribonucleoside metabolic processGO:00091192450.015
ribonucleoside triphosphate metabolic processGO:00091992200.015
positive regulation of lymphocyte activationGO:00512511400.015
cellular homeostasisGO:00197252400.015
regulation of intracellular transportGO:00323861590.015
regulation of apoptotic signaling pathwayGO:20012331970.015
negative regulation of cellular component organizationGO:00511291940.015
macromolecule catabolic processGO:00090572810.015
regulation of osteoblast differentiationGO:0045667670.015
gland developmentGO:00487323300.014
compound eye developmentGO:004874910.014
protein localization to nucleusGO:00345041210.014
regulation of cellular component sizeGO:00325351210.014
camera type eye developmentGO:00430102660.014
protein targeting to peroxisomeGO:000662540.014
positive regulation of t cell activationGO:00508701010.014
cellular ion homeostasisGO:00068731650.014
g protein coupled receptor signaling pathwayGO:00071862430.014
cellular chemical homeostasisGO:00550822150.014
neural tube developmentGO:00219151600.014
circulatory system processGO:00030131970.014
epithelial cell proliferationGO:00506731740.014
polysaccharide metabolic processGO:0005976390.014
positive regulation of protein kinase activityGO:00458601440.014
synapse organizationGO:00508081250.014
tube formationGO:00351481400.014
embryonic epithelial tube formationGO:00018381300.014
cytokine metabolic processGO:0042107710.014
sphingosine 1 phosphate signaling pathwayGO:000337630.014
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.013
regulation of leukocyte proliferationGO:00706631210.013
cellular metal ion homeostasisGO:00068751510.013
ribose phosphate metabolic processGO:00196932910.013
immune effector processGO:00022523210.013
sterol metabolic processGO:0016125580.013
cellular response to cytokine stimulusGO:00713451890.013
purine nucleoside catabolic processGO:00061522050.013
action potentialGO:0001508780.013
myeloid cell differentiationGO:00300992330.013
negative regulation of cellular catabolic processGO:0031330470.013
nucleocytoplasmic transportGO:00069131390.013
regulation of cell projection organizationGO:00313442060.013
organelle fissionGO:00482851700.013
cellular carbohydrate metabolic processGO:00442621190.013
lymphocyte proliferationGO:00466511640.013
peptidyl lysine modificationGO:0018205770.013
plasma membrane organizationGO:0007009900.013
autophagic vacuole assemblyGO:0000045130.013
regulation of ion transportGO:00432692150.013
chromatin organizationGO:00063252060.013
epithelial tube morphogenesisGO:00605623030.013
t cell proliferationGO:00420981200.013
regulation of response to biotic stimulusGO:0002831380.013
alcohol metabolic processGO:00060661160.013
connective tissue developmentGO:00614481790.013
angiogenesisGO:00015252010.013
ras protein signal transductionGO:0007265770.013
bone developmentGO:00603481200.013
regulation of cytokine biosynthetic processGO:0042035590.013
modification dependent macromolecule catabolic processGO:00436321330.013
nuclear divisionGO:00002801580.013
regulation of autophagic vacuole assemblyGO:200078540.013
single organism cell adhesionGO:00986021560.013
ion transmembrane transportGO:00342203610.013
glial cell differentiationGO:00100011310.013
regulation of protein localizationGO:00328802310.012
purine ribonucleoside catabolic processGO:00461302050.012
apoptotic signaling pathwayGO:00971903060.012
positive regulation of organelle organizationGO:00106381280.012
ear developmentGO:00435832000.012
cellular response to biotic stimulusGO:0071216920.012
defense response to other organismGO:00985421970.012
regulation of lymphocyte activationGO:00512492400.012
regulation of peptidyl tyrosine phosphorylationGO:0050730930.012
gtp metabolic processGO:00460391440.012
membrane fusionGO:0061025380.012
purine ribonucleotide catabolic processGO:00091542080.012
regulation of defense responseGO:00313472330.012
dna metabolic processGO:00062593030.012
organelle localizationGO:00516401790.012
heart morphogenesisGO:00030071780.012
myelinationGO:0042552740.012
renal system developmentGO:00720012250.012
lymphocyte differentiationGO:00300982420.012
peptide transportGO:00158331330.012
macromolecule methylationGO:00434141200.012
actin filament organizationGO:00070151130.012
ribonucleoside catabolic processGO:00424542060.012
cellular protein catabolic processGO:00442571550.012
learning or memoryGO:00076111480.012
hormone secretionGO:00468791280.012
synaptic transmissionGO:00072683290.012
skeletal muscle organ developmentGO:00605381630.012
negative regulation of neuron differentiationGO:00456651010.012
nucleoside triphosphate catabolic processGO:00091432050.012
negative regulation of organelle organizationGO:0010639900.011
negative regulation of secretionGO:0051048610.011
negative regulation of phosphorus metabolic processGO:00105631840.011
lipid homeostasisGO:0055088630.011
neuromuscular processGO:0050905990.011
purine nucleoside triphosphate catabolic processGO:00091462030.011
negative regulation of molecular functionGO:00440922580.011
intrinsic apoptotic signaling pathwayGO:00971931320.011
purine ribonucleoside triphosphate catabolic processGO:00092071990.011
positive regulation of cytokine productionGO:00018191740.011
glycerophospholipid metabolic processGO:0006650710.011
leukocyte migrationGO:00509001240.011
protein modification by small protein conjugation or removalGO:00706472070.011
actin cytoskeleton organizationGO:00300362200.011
positive regulation of hydrolase activityGO:00513451480.011
mitochondrion organizationGO:00070051340.011
regulation of reactive oxygen species metabolic processGO:2000377400.011
calcium ion homeostasisGO:00550741270.011
cellular calcium ion homeostasisGO:00068741190.011
negative regulation of growthGO:0045926990.011
cellular response to transforming growth factor beta stimulusGO:0071560880.011
cellular response to organonitrogen compoundGO:00714171450.011
regulation of cytoskeleton organizationGO:00514931220.011
protein localization to membraneGO:00726571080.011
cellular response to acid chemicalGO:0071229680.011
hormone metabolic processGO:0042445860.011
reactive oxygen species metabolic processGO:0072593840.011
gastrulationGO:00073691160.011
epithelial tube formationGO:00721751300.011
peptidyl tyrosine modificationGO:00182121450.011
peptidyl tyrosine phosphorylationGO:00181081430.011
establishment of protein localization to peroxisomeGO:007266340.011
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.011
divalent inorganic cation transportGO:00725111780.011
response to acid chemicalGO:00011011110.011
nuclear importGO:0051170950.011
regulation of multi organism processGO:00439001110.011
leukocyte proliferationGO:00706611720.011
negative regulation of protein phosphorylationGO:00019331260.011
lipid oxidationGO:0034440290.011
positive regulation of transferase activityGO:00513471670.010
regulation of cell adhesionGO:00301551540.010
organic hydroxy compound biosynthetic processGO:1901617770.010
regulation of attachment of spindle microtubules to kinetochoreGO:005198830.010
male gamete generationGO:00482322850.010
development of primary sexual characteristicsGO:00451371430.010
nucleotide biosynthetic processGO:0009165780.010
negative regulation of chemokine productionGO:003268240.010
positive regulation of cell deathGO:00109422240.010
homeostasis of number of cellsGO:00488722100.010
negative regulation of apoptotic signaling pathwayGO:20012341040.010
tissue homeostasisGO:00018941150.010
divalent inorganic cation homeostasisGO:00725071380.010
cardiac chamber developmentGO:00032051080.010
spermatid developmentGO:00072861080.010
regulation of reproductive processGO:2000241660.010

Smpd2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.033
inherited metabolic disorderDOID:65500.033
disease of anatomical entityDOID:700.012
nervous system diseaseDOID:86300.012
central nervous system diseaseDOID:33100.012
immune system diseaseDOID:291400.010