IMP: Integrative Multi-species Prediction

Mus musculus

57 known processes

Fxr1

fragile X mental retardation gene 1, autosomal homolog

(Aliases: AI851072,1110050J02Rik,9530073J07Rik,Fxr1h,Fxr1p)

Ensembl: ENSMUSG00000027680
Entrez: 14359
UniProtKB: Q61584

Process Predictions
Disease Predictions

Fxr1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
translational initiation	GO:0006413	24	0.440	Mouse
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.376	Fly
axoneme assembly	GO:0035082	15	0.366	Fly
cilium morphogenesis	GO:0060271	102	0.298	Fly
translation	GO:0006412	93	0.274
oocyte construction	GO:0007308	2	0.234	Fly
male gamete generation	GO:0048232	285	0.234	Fly
regulation of insulin receptor signaling pathway	GO:0046626	21	0.193	Fly
negative regulation of insulin receptor signaling pathway	GO:0046627	14	0.189	Fly
cellularization	GO:0007349	1	0.185	Fly
nucleic acid transport	GO:0050657	18	0.172	Fly
olfactory learning	GO:0008355	2	0.167	Fly
synaptic transmission	GO:0007268	329	0.162	Fly
spermatogenesis	GO:0007283	284	0.161	Fly
rna localization	GO:0006403	23	0.159	Fly
response to peptide hormone	GO:0043434	127	0.154	Fly
negative regulation of cellular protein metabolic process	GO:0032269	247	0.150
nitrogen compound transport	GO:0071705	271	0.147	Fly
organelle assembly	GO:0070925	177	0.147	Fly
stem cell differentiation	GO:0048863	268	0.147
spermatid differentiation	GO:0048515	115	0.146	Fly
microtubule based process	GO:0007017	236	0.137	Fly
cellular response to insulin stimulus	GO:0032869	78	0.133	Fly
negative regulation of translation	GO:0017148	22	0.131
habituation	GO:0046959	3	0.131	Fly
germ cell development	GO:0007281	185	0.131	Fly
stem cell development	GO:0048864	219	0.128
cilium assembly	GO:0042384	81	0.128	Fly
negative regulation of translational initiation	GO:0045947	4	0.123	Mouse
regulation of translation	GO:0006417	71	0.112
cellular component assembly involved in morphogenesis	GO:0010927	139	0.112	Fly
negative regulation of cellular response to insulin stimulus	GO:1900077	16	0.104	Fly
insulin receptor signaling pathway	GO:0008286	49	0.103	Fly
macromolecule catabolic process	GO:0009057	281	0.103
heterochromatin organization	GO:0070828	4	0.102	Fly
cellular protein catabolic process	GO:0044257	155	0.099
posttranscriptional regulation of gene expression	GO:0010608	155	0.098
response to organonitrogen compound	GO:0010243	246	0.097	Fly
regulation of translational initiation	GO:0006446	15	0.097	Mouse
establishment of rna localization	GO:0051236	18	0.095	Fly
synapse organization	GO:0050808	125	0.094	Fly
cellular response to peptide hormone stimulus	GO:0071375	92	0.091	Fly
negative regulation of cellular component organization	GO:0051129	194	0.089	Fly
cellular macromolecule catabolic process	GO:0044265	206	0.087
detection of stimulus	GO:0051606	84	0.085	Fly
chromatin modification	GO:0016568	187	0.083	Fly
response to peptide	GO:1901652	136	0.083	Fly
regulation of neurotransmitter levels	GO:0001505	87	0.081	Fly
nucleoside triphosphate metabolic process	GO:0009141	230	0.081
cellular response to organonitrogen compound	GO:0071417	145	0.081	Fly
nucleoside triphosphate catabolic process	GO:0009143	205	0.079
aromatic compound catabolic process	GO:0019439	286	0.076
spermatid development	GO:0007286	108	0.075	Fly
cellular response to peptide	GO:1901653	92	0.075	Fly
negative regulation of protein metabolic process	GO:0051248	282	0.073
purine containing compound metabolic process	GO:0072521	311	0.073
nucleoside metabolic process	GO:0009116	246	0.073
negative regulation of growth	GO:0045926	99	0.072	Fly
nucleoside phosphate catabolic process	GO:1901292	222	0.071
regulation of synapse structural plasticity	GO:0051823	4	0.066	Fly
cellular response to hormone stimulus	GO:0032870	150	0.065	Fly
sensory perception of touch	GO:0050975	2	0.065	Fly
heterochromatin assembly	GO:0031507	2	0.064	Fly
purine ribonucleotide catabolic process	GO:0009154	208	0.064
response to insulin	GO:0032868	100	0.064	Fly
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.063
dna conformation change	GO:0071103	37	0.062	Fly
cellular nitrogen compound catabolic process	GO:0044270	280	0.062
male courtship behavior	GO:0008049	2	0.062	Fly
locomotory behavior	GO:0007626	195	0.061	Fly
protein catabolic process	GO:0030163	221	0.061
organic cyclic compound catabolic process	GO:1901361	295	0.060
neurotransmitter secretion	GO:0007269	62	0.060	Fly
dna metabolic process	GO:0006259	303	0.059	Fly
regulation of cell cycle	GO:0051726	281	0.058	Fly
negative regulation of neuron differentiation	GO:0045665	101	0.058	Fly
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.057
regulation of cellular component biogenesis	GO:0044087	181	0.057	Fly
mitotic cell cycle	GO:0000278	195	0.055	Fly
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.054
heterocycle catabolic process	GO:0046700	280	0.052
fertilization	GO:0009566	127	0.052
negative regulation of cell development	GO:0010721	169	0.052	Fly
glycosyl compound metabolic process	GO:1901657	246	0.051
carbohydrate derivative catabolic process	GO:1901136	231	0.051
modification dependent macromolecule catabolic process	GO:0043632	133	0.050
rna transport	GO:0050658	18	0.049	Fly
dendrite development	GO:0016358	115	0.049	Fly
negative regulation of neuron projection development	GO:0010977	50	0.048	Fly
ribose phosphate metabolic process	GO:0019693	291	0.047
morphogenesis of a branching structure	GO:0001763	203	0.047
purine ribonucleoside catabolic process	GO:0046130	205	0.047
regulation of neuron differentiation	GO:0045664	281	0.047	Fly
protein modification by small protein conjugation or removal	GO:0070647	207	0.047
ribonucleotide catabolic process	GO:0009261	208	0.046
purine ribonucleotide metabolic process	GO:0009150	290	0.045
regulation of system process	GO:0044057	200	0.045	Fly
negative regulation of dendrite development	GO:2000171	9	0.045	Fly
ribonucleotide metabolic process	GO:0009259	291	0.045
nucleotide metabolic process	GO:0009117	332	0.045
striated muscle tissue development	GO:0014706	293	0.044	Zebrafish
cognition	GO:0050890	149	0.043	Fly
negative regulation of cell projection organization	GO:0031345	56	0.043	Fly
nucleotide catabolic process	GO:0009166	217	0.042
cell maturation	GO:0048469	127	0.041	Fly
purine ribonucleoside metabolic process	GO:0046128	241	0.040
chromatin organization	GO:0006325	206	0.040	Fly
regulation of neural precursor cell proliferation	GO:2000177	70	0.040	Fly
maintenance of location	GO:0051235	89	0.040
regulation of mitotic cell cycle	GO:0007346	126	0.039	Fly
proteasomal protein catabolic process	GO:0010498	98	0.039
purine nucleoside catabolic process	GO:0006152	205	0.039
protein modification by small protein conjugation	GO:0032446	187	0.038
negative regulation of nervous system development	GO:0051961	156	0.038	Fly
ribonucleoside catabolic process	GO:0042454	206	0.038
detection of abiotic stimulus	GO:0009582	60	0.038	Fly
atp catabolic process	GO:0006200	55	0.037
nucleoside phosphate metabolic process	GO:0006753	338	0.037
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.037
developmental maturation	GO:0021700	193	0.037	Fly
neural precursor cell proliferation	GO:0061351	121	0.037	Fly
organophosphate catabolic process	GO:0046434	232	0.036
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.036
multi multicellular organism process	GO:0044706	109	0.035	Fly
multicellular organism growth	GO:0035264	161	0.035
nucleoside catabolic process	GO:0009164	206	0.034
learning or memory	GO:0007611	148	0.033	Fly
regulation of stem cell proliferation	GO:0072091	78	0.033	Fly
purine nucleoside metabolic process	GO:0042278	241	0.033
detection of mechanical stimulus involved in sensory perception	GO:0050974	23	0.033	Fly
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.033	Fly
regulation of kinase activity	GO:0043549	249	0.033
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.032
rhythmic process	GO:0048511	174	0.032	Fly
cell recognition	GO:0008037	83	0.032	Fly
chemotaxis	GO:0006935	247	0.032	Fly
cellular amine metabolic process	GO:0044106	44	0.031
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.030
apoptotic signaling pathway	GO:0097190	306	0.030
purine nucleotide catabolic process	GO:0006195	211	0.030
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.030
regulation of cell cycle phase transition	GO:1901987	77	0.030
dna packaging	GO:0006323	30	0.030	Fly
muscle tissue development	GO:0060537	308	0.029	Zebrafish
nuclear division	GO:0000280	158	0.029
axonal fasciculation	GO:0007413	15	0.029	Fly
regulation of cellular response to insulin stimulus	GO:1900076	30	0.029	Fly
purine containing compound catabolic process	GO:0072523	213	0.029
transmembrane transport	GO:0055085	412	0.028
regulation of cell projection organization	GO:0031344	206	0.028	Fly
regulation of cellular ketone metabolic process	GO:0010565	66	0.028
positive regulation of nervous system development	GO:0051962	221	0.028	Fly
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.028
amine metabolic process	GO:0009308	45	0.027
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.027
rna interference	GO:0016246	2	0.026
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.026
cell fate commitment	GO:0045165	210	0.026	Fly
purine nucleotide metabolic process	GO:0006163	302	0.026
glycosyl compound catabolic process	GO:1901658	206	0.026
nucleobase containing small molecule metabolic process	GO:0055086	352	0.026
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.025
muscle cell differentiation	GO:0042692	261	0.025	Zebrafish
nucleoside monophosphate catabolic process	GO:0009125	59	0.025
regulation of synapse assembly	GO:0051963	29	0.025	Fly
organonitrogen compound catabolic process	GO:1901565	264	0.025
cellular protein complex assembly	GO:0043623	116	0.025
nucleocytoplasmic transport	GO:0006913	139	0.025
cellular ketone metabolic process	GO:0042180	84	0.025
intracellular protein transport	GO:0006886	204	0.025
cytoplasmic transport	GO:0016482	234	0.024
membrane organization	GO:0061024	245	0.024
mitotic nuclear division	GO:0007067	48	0.024
connective tissue development	GO:0061448	179	0.024
peptidyl amino acid modification	GO:0018193	336	0.024
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.024
negative regulation of cell morphogenesis involved in differentiation	GO:0010771	48	0.024	Fly
chromatin assembly	GO:0031497	13	0.024	Fly
protein ubiquitination	GO:0016567	171	0.024
organelle localization	GO:0051640	179	0.023
detection of external stimulus	GO:0009581	61	0.023	Fly
cellular response to dna damage stimulus	GO:0006974	207	0.023
associative learning	GO:0008306	61	0.023	Fly
detection of mechanical stimulus	GO:0050982	27	0.023	Fly
stem cell maintenance	GO:0019827	130	0.023
modification dependent protein catabolic process	GO:0019941	133	0.022
lipid localization	GO:0010876	126	0.022
development of primary sexual characteristics	GO:0045137	143	0.022
mitotic cell cycle process	GO:1903047	159	0.022
ribonucleoside metabolic process	GO:0009119	245	0.022
mitochondrion organization	GO:0007005	134	0.022
cell growth	GO:0016049	130	0.022
memory	GO:0007613	58	0.022	Fly
positive regulation of programmed cell death	GO:0043068	218	0.022
regulation of cellular amine metabolic process	GO:0033238	20	0.021
neuromuscular synaptic transmission	GO:0007274	16	0.021	Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.021
regulation of protein catabolic process	GO:0042176	108	0.021
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.021
nucleoside monophosphate metabolic process	GO:0009123	85	0.020
learning	GO:0007612	98	0.020	Fly
regulation of neurological system process	GO:0031644	22	0.020	Fly
oogenesis	GO:0048477	56	0.020	Fly
microtubule cytoskeleton organization	GO:0000226	157	0.020	Fly
protein maturation	GO:0051604	176	0.020
oocyte differentiation	GO:0009994	35	0.019	Fly
regulation of organelle organization	GO:0033043	289	0.019
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.019
chromatin assembly or disassembly	GO:0006333	16	0.019	Fly
cartilage development	GO:0051216	140	0.019
regulation of cellular response to stress	GO:0080135	159	0.019
synapse assembly	GO:0007416	56	0.017	Fly
cation homeostasis	GO:0055080	212	0.017
cation transport	GO:0006812	399	0.017
regionalization	GO:0003002	337	0.017	Zebrafish Fly
meiotic cell cycle	GO:0051321	122	0.017
atp metabolic process	GO:0046034	75	0.017
cell fate specification	GO:0001708	72	0.017
negative regulation of mitotic cell cycle	GO:0045930	58	0.017
cellular homeostasis	GO:0019725	240	0.017
regulation of protein localization	GO:0032880	231	0.017
neural tube development	GO:0021915	160	0.017
positive regulation of cell death	GO:0010942	224	0.017
regulation of hydrolase activity	GO:0051336	246	0.017
neural tube patterning	GO:0021532	43	0.017
adult behavior	GO:0030534	135	0.016
neuron projection guidance	GO:0097485	141	0.016	Fly
negative regulation of protein modification process	GO:0031400	163	0.016
positive regulation of stem cell proliferation	GO:2000648	59	0.016	Fly
epithelial to mesenchymal transition	GO:0001837	47	0.016
detection of stimulus involved in sensory perception	GO:0050906	44	0.016	Fly
regulation of intracellular transport	GO:0032386	159	0.016
female gamete generation	GO:0007292	74	0.016	Fly
protein refolding	GO:0042026	1	0.016
stem cell proliferation	GO:0072089	117	0.016	Fly
nuclear transport	GO:0051169	139	0.016
oocyte development	GO:0048599	33	0.015	Fly
regulation of protein maturation	GO:1903317	96	0.015
negative regulation of intracellular signal transduction	GO:1902532	167	0.015
cation transmembrane transport	GO:0098655	266	0.015
regulation of cellular amino acid metabolic process	GO:0006521	5	0.015
regulation of transferase activity	GO:0051338	263	0.015
regulation of establishment of protein localization	GO:0070201	181	0.015
regulation of embryonic development	GO:0045995	71	0.015	Fly
meiotic nuclear division	GO:0007126	115	0.015
protein processing	GO:0016485	163	0.015
adaptive immune response	GO:0002250	155	0.015
leukocyte mediated immunity	GO:0002443	174	0.014
positive regulation of apoptotic process	GO:0043065	217	0.014
establishment of organelle localization	GO:0051656	122	0.014
positive regulation of cell cycle	GO:0045787	92	0.014
positive regulation of cellular amine metabolic process	GO:0033240	5	0.014
multi organism reproductive behavior	GO:0044705	29	0.014	Fly
negative regulation of protein maturation	GO:1903318	79	0.014
t cell activation	GO:0042110	289	0.014
regulation of cell migration	GO:0030334	219	0.014
cellular amino acid metabolic process	GO:0006520	103	0.014
regulation of cell motility	GO:2000145	236	0.014
response to light stimulus	GO:0009416	135	0.014
positive regulation of cellular catabolic process	GO:0031331	148	0.014
immune effector process	GO:0002252	321	0.014
regulation of proteolysis	GO:0030162	164	0.013
short term memory	GO:0007614	5	0.013	Fly
negative regulation of phosphorylation	GO:0042326	166	0.013
axonogenesis	GO:0007409	274	0.013	Fly
cell adhesion	GO:0007155	329	0.013
oocyte axis specification	GO:0007309	2	0.013	Fly
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.013
response to inorganic substance	GO:0010035	96	0.013
rna processing	GO:0006396	105	0.013
cellular chemical homeostasis	GO:0055082	215	0.013
inflammatory response	GO:0006954	244	0.013
regulation of cellular component size	GO:0032535	121	0.013
skeletal system development	GO:0001501	356	0.013
mating	GO:0007618	27	0.013	Fly
response to growth factor	GO:0070848	198	0.013
ubiquitin dependent protein catabolic process	GO:0006511	129	0.013
regulation of protein serine threonine kinase activity	GO:0071900	157	0.013
regulation of protein transport	GO:0051223	163	0.013
histone modification	GO:0016570	159	0.012
mapk cascade	GO:0000165	281	0.012
rhythmic behavior	GO:0007622	15	0.012	Fly
b cell activation	GO:0042113	161	0.012
negative regulation of phosphate metabolic process	GO:0045936	184	0.012
regulation of cellular protein catabolic process	GO:1903362	61	0.012
neural crest formation	GO:0014029	2	0.012
regulation of ion transport	GO:0043269	215	0.012
organelle fission	GO:0048285	170	0.012
forebrain development	GO:0030900	302	0.012
protein localization to organelle	GO:0033365	185	0.012
neuron migration	GO:0001764	122	0.012
single fertilization	GO:0007338	82	0.012
myosin filament organization	GO:0031033	3	0.012
regulation of cytoplasmic transport	GO:1903649	112	0.012
carbohydrate homeostasis	GO:0033500	128	0.012
myosin filament assembly	GO:0031034	2	0.012
ion transmembrane transport	GO:0034220	361	0.011
negative regulation of immune system process	GO:0002683	209	0.011
mating behavior	GO:0007617	20	0.011	Fly
sister chromatid segregation	GO:0000819	20	0.011
regulation of protein kinase activity	GO:0045859	232	0.011
striated muscle myosin thick filament assembly	GO:0071688	1	0.011
cell activation involved in immune response	GO:0002263	126	0.011
blastocyst development	GO:0001824	80	0.011
regulation of chromosome organization	GO:0033044	83	0.011
lymphocyte activation involved in immune response	GO:0002285	93	0.011
intracellular receptor signaling pathway	GO:0030522	74	0.011
mesenchyme development	GO:0060485	152	0.011
regulation of cell activation	GO:0050865	289	0.011
negative regulation of molecular function	GO:0044092	258	0.011
negative regulation of phosphorus metabolic process	GO:0010563	184	0.011
regulation of transmembrane transport	GO:0034762	128	0.011
regulation of neuroblast proliferation	GO:1902692	27	0.011	Fly
multicellular organismal signaling	GO:0035637	91	0.011
negative regulation of synapse assembly	GO:0051964	3	0.011	Fly
regulation of protein processing	GO:0070613	96	0.011
regulation of proteasomal protein catabolic process	GO:0061136	46	0.011
ossification	GO:0001503	216	0.011
regulation of purine nucleotide metabolic process	GO:1900542	169	0.011
striated muscle cell development	GO:0055002	125	0.011	Zebrafish
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.011
establishment of protein localization to organelle	GO:0072594	118	0.010
lymphocyte mediated immunity	GO:0002449	139	0.010
inorganic cation transmembrane transport	GO:0098662	207	0.010
compound eye development	GO:0048749	1	0.010
ras protein signal transduction	GO:0007265	77	0.010
endocytosis	GO:0006897	168	0.010
regulation of nucleocytoplasmic transport	GO:0046822	73	0.010
sleep	GO:0030431	7	0.010	Fly
negative regulation of cell proliferation	GO:0008285	296	0.010
skeletal muscle organ development	GO:0060538	163	0.010	Zebrafish
macromolecular complex disassembly	GO:0032984	43	0.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.010
nucleic acid phosphodiester bond hydrolysis	GO:0090305	49	0.010
negative regulation of organelle organization	GO:0010639	90	0.010
neuron death	GO:0070997	154	0.010
endomembrane system organization	GO:0010256	147	0.010
multicellular organismal homeostasis	GO:0048871	164	0.010
regulation of secretion by cell	GO:1903530	249	0.010
developmental growth involved in morphogenesis	GO:0060560	138	0.010

Fxr1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.269
central nervous system disease	DOID:331	0.269
disease of anatomical entity	DOID:7	0.269
neurodegenerative disease	DOID:1289	0.051
reproductive system disease	DOID:15	0.024
cancer	DOID:162	0.013
disease of cellular proliferation	DOID:14566	0.013
organ system cancer	DOID:0050686	0.013
x linked disease	DOID:0050735	0.011

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