Mus musculus

0 known processes

Map3k8

mitogen-activated protein kinase kinase kinase 8

(Aliases: Estf,Est,Cot,Tpl-2,Tpl2,Cot/Tpl2,c-COT)

Map3k8 biological process predictions


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Biological processGO term IDProcess sizeProbabilityFunc Analog Org
activation of innate immune responseGO:0002218560.998
toll like receptor signaling pathwayGO:0002224380.997
positive regulation of innate immune responseGO:0045089800.994
cytoplasmic pattern recognition receptor signaling pathwayGO:0002753100.988
response to interleukin 12GO:007067120.987
activation of immune responseGO:00022531380.985
immune response activating signal transductionGO:00027571160.984
cellular response to molecule of bacterial originGO:0071219830.980
cellular response to biotic stimulusGO:0071216920.979
regulation of innate immune responseGO:0045088910.976
pattern recognition receptor signaling pathwayGO:0002221470.971
cellular response to lipopolysaccharideGO:0071222770.959
cytokine productionGO:00018163190.958
cytokine mediated signaling pathwayGO:00192211150.956
regulation of defense responseGO:00313472330.954
cellular response to cytokine stimulusGO:00713451890.953
i kappab kinase nf kappab signalingGO:0007249850.946
innate immune response activating signal transductionGO:0002758500.942
immune response regulating signaling pathwayGO:00027641250.924
innate immune responseGO:00450871570.917
positive regulation of defense responseGO:00313491240.903
tumor necrosis factor productionGO:0032640500.899
regulation of chemokine productionGO:0032642300.887
regulation of tumor necrosis factor productionGO:0032680490.886
positive regulation of cytokine productionGO:00018191740.883
nucleotide binding oligomerization domain containing signaling pathwayGO:007042360.878
response to lipopolysaccharideGO:00324961280.857
regulation of cd8 positive alpha beta cytotoxic t cell extravasationGO:200045220.850
regulation of cytokine productionGO:00018172660.836
response to molecule of bacterial originGO:00022371430.831
regulation of lymphocyte activationGO:00512492400.815
regulation of interleukin 6 productionGO:0032675550.789
regulation of interleukin 8 productionGO:003267730.788
regulation of cell activationGO:00508652890.784
tumor necrosis factor superfamily cytokine productionGO:0071706510.784
defense response to other organismGO:00985421970.778
defense response to virusGO:0051607680.762
ripoptosome assembly involved in necroptotic processGO:190102660.737
alpha beta t cell differentiation involved in immune responseGO:0002293300.704
positive regulation of cell activationGO:00508671580.702
cd4 positive alpha beta t cell differentiation involved in immune responseGO:0002294280.689
response to interleukin 1GO:0070555110.680
nucleotide binding oligomerization domain containing 1 signaling pathwayGO:007042750.674
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555500.663
cellular response to lipidGO:00713961450.657
positive regulation of interleukin 8 productionGO:003275720.654
regulation of sequence specific dna binding transcription factor activityGO:00510901060.648
positive regulation of chemokine productionGO:0032722220.639
positive regulation of lymphocyte activationGO:00512511400.634
regulation of reactive oxygen species metabolic processGO:2000377400.631
positive regulation of t helper 1 cell differentiationGO:004562740.630
interleukin 8 productionGO:003263740.596
t helper cell differentiationGO:0042093280.588
immune effector processGO:00022523210.588
positive regulation of tumor necrosis factor productionGO:0032760300.585
alpha beta t cell activation involved in immune responseGO:0002287310.580
t cell activation involved in immune responseGO:0002286430.575
regulation of necroptotic processGO:0060544100.572
chemokine productionGO:0032602340.569
cd4 positive alpha beta t cell differentiationGO:0043367410.564
inflammatory responseGO:00069542440.564
cytokine metabolic processGO:0042107710.548
cell activation involved in immune responseGO:00022631260.547
negative regulation of immune system processGO:00026832090.542
cellular response to peptidoglycanGO:007122440.532
lymphocyte differentiationGO:00300982420.529
negative regulation of cytokine productionGO:0001818840.525
positive regulation of response to cytokine stimulusGO:0060760110.521
peptidyl amino acid modificationGO:00181933360.499
t cell activationGO:00421102890.494
positive regulation of t cell differentiationGO:0045582520.485
positive regulation of immature t cell proliferationGO:003309140.461
cd4 positive alpha beta t cell activationGO:0035710450.450
regulation of leukocyte differentiationGO:19021051590.448
positive regulation of lymphocyte differentiationGO:0045621610.447
adaptive immune responseGO:00022501550.444
cellular response to organonitrogen compoundGO:00714171450.441
intracellular receptor signaling pathwayGO:0030522740.436
t cell apoptotic processGO:0070231390.432
positive regulation of cytokine biosynthetic processGO:0042108400.427
positive regulation of reactive oxygen species metabolic processGO:2000379110.425
leukocyte activation involved in immune responseGO:00023661260.420
t cell differentiation involved in immune responseGO:0002292300.414
positive regulation of apoptotic processGO:00430652170.410
lipopolysaccharide mediated signaling pathwayGO:0031663250.409
regulation of transferase activityGO:00513382630.404
positive regulation of interferon alpha productionGO:003272740.402
jnk cascadeGO:0007254720.396
regulation of cellular amino acid metabolic processGO:000652150.395
regulation of leukocyte proliferationGO:00706631210.394
regulation of defense response to fungusGO:190015010.386
defense response to gram positive bacteriumGO:0050830500.386
mapk cascadeGO:00001652810.382
alpha beta t cell differentiationGO:0046632690.381
myeloid leukocyte activationGO:0002274830.379
type i interferon productionGO:0032606290.377
response to organic cyclic compoundGO:00140701980.376
homeostasis of number of cellsGO:00488722100.368
toll like receptor 4 signaling pathwayGO:003414290.367
cell type specific apoptotic processGO:00972852680.366
positive regulation of nf kappab transcription factor activityGO:0051092300.351
positive regulation of erk1 and erk2 cascadeGO:0070374470.349
t helper 1 cell differentiationGO:0045063130.348
nik nf kappab signalingGO:0038061140.348
regulation of interferon gamma productionGO:0032649570.344
positive regulation of type i interferon productionGO:0032481140.340
t helper 1 type immune responseGO:0042088250.335
positive regulation of antimicrobial peptide productionGO:000222510.333
regulation of lymphocyte apoptotic processGO:0070228410.330
defense response to bacteriumGO:00427421190.329
positive regulation of protein modification processGO:00314012990.321
positive regulation of programmed cell deathGO:00430682180.316
nucleotide binding oligomerization domain containing 2 signaling pathwayGO:007043160.316
positive regulation of immune effector processGO:00026991070.312
antigen receptor mediated signaling pathwayGO:0050851640.310
interleukin 6 productionGO:0032635580.308
apoptotic signaling pathwayGO:00971903060.300
positive regulation of stress activated mapk cascadeGO:0032874480.298
toll like receptor 3 signaling pathwayGO:003413840.296
lymphocyte proliferationGO:00466511640.293
leukocyte migrationGO:00509001240.288
regulation of toll like receptor signaling pathwayGO:0034121200.278
reactive oxygen species metabolic processGO:0072593840.275
positive regulation of mapk cascadeGO:00434101700.271
cellular ketone metabolic processGO:0042180840.269
positive regulation of cell deathGO:00109422240.268
cellular amino acid metabolic processGO:00065201030.267
t cell proliferationGO:00420981200.266
regulation of interleukin 2 productionGO:0032663280.265
antimicrobial peptide productionGO:000277520.260
necroptotic processGO:0070266210.259
carbohydrate metabolic processGO:00059752300.258
lymphocyte apoptotic processGO:0070227540.257
interferon gamma productionGO:0032609670.256
regulation of t cell activationGO:00508631700.253
leukocyte proliferationGO:00706611720.247
positive regulation of interleukin 6 productionGO:0032755370.241
positive regulation of type i interferon mediated signaling pathwayGO:006034040.239
regulation of response to cytokine stimulusGO:0060759230.237
b cell activationGO:00421131610.234
leukocyte differentiationGO:00025213420.232
reactive nitrogen species metabolic processGO:200105700.231
regulation of t helper 1 cell differentiationGO:004562570.231
positive regulation of lymphocyte proliferationGO:0050671700.228
regulation of leukocyte apoptotic processGO:2000106560.228
regulation of stress activated mapk cascadeGO:0032872690.223
regulation of t cell differentiationGO:0045580830.222
negative regulation of phosphate metabolic processGO:00459361840.220
response to dsrnaGO:0043331300.218
regulation of response to woundingGO:19030341890.218
regulation of defense response to bacteriumGO:190042430.213
stress activated protein kinase signaling cascadeGO:0031098810.212
regulation of protein kinase activityGO:00458592320.211
regulation of nucleotide binding oligomerization domain containing 1 signaling pathwayGO:007042830.211
regulation of necrotic cell deathGO:0010939130.209
positive regulation of leukocyte differentiationGO:1902107860.208
myeloid cell differentiationGO:00300992330.208
regulation of interferon beta biosynthetic processGO:004535740.206
negative regulation of lymphocyte activationGO:0051250910.205
interleukin 2 productionGO:0032623330.205
alpha beta t cell activationGO:0046631910.205
leukocyte homeostasisGO:0001776790.204
regulation of cellular catabolic processGO:00313292420.203
interferon beta productionGO:0032608160.202
lymphocyte activation involved in immune responseGO:0002285930.202
regulation of multi organism processGO:00439001110.199
t cell differentiationGO:00302171740.199
regulation of adaptive immune responseGO:0002819900.198
regulation of protein transportGO:00512231630.198
cellular amine metabolic processGO:0044106440.197
extrinsic apoptotic signaling pathwayGO:00971911260.195
response to organonitrogen compoundGO:00102432460.194
wound healingGO:00420601570.191
positive regulation of jnk cascadeGO:0046330460.190
lymphocyte mediated immunityGO:00024491390.188
regulation of lymphocyte proliferationGO:00506701170.185
negative regulation of cell proliferationGO:00082852960.185
peptidyl tyrosine phosphorylationGO:00181081430.185
regulation of cellular response to stressGO:00801351590.184
interleukin 1 mediated signaling pathwayGO:007049840.182
t cell extravasationGO:007268340.181
negative regulation of cellular protein metabolic processGO:00322692470.181
positive regulation of alpha beta t cell differentiationGO:0046638280.181
regulation of antimicrobial humoral responseGO:000275930.180
negative regulation of intracellular signal transductionGO:19025321670.180
positive regulation of interferon gamma productionGO:0032729390.179
positive regulation of t cell activationGO:00508701010.178
positive regulation of antimicrobial humoral responseGO:000276020.176
regulation of cytokine production involved in immune responseGO:0002718260.172
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.171
regulation of cell killingGO:0031341400.169
regulation of alpha beta t cell activationGO:0046634530.167
regulation of protein deacetylationGO:0090311170.166
interleukin 18 mediated signaling pathwayGO:003565520.166
positive regulation of apoptotic signaling pathwayGO:2001235950.165
regulation of cellular amine metabolic processGO:0033238200.164
leukocyte apoptotic processGO:0071887710.162
toll like receptor 7 signaling pathwayGO:003415440.160
regulation of cell migrationGO:00303342190.160
regulation of secretion by cellGO:19035302490.160
immune response regulating cell surface receptor signaling pathwayGO:0002768800.159
cd8 positive alpha beta cytotoxic t cell extravasationGO:003569820.159
regulation of cell motilityGO:20001452360.157
positive regulation of protein phosphorylationGO:00019342420.155
regulation of lymphocyte differentiationGO:00456191070.155
cytokine biosynthetic processGO:0042089680.154
myeloid leukocyte differentiationGO:00025731190.152
regulation of leukocyte mediated immunityGO:00027031040.152
positive regulation of cellular amine metabolic processGO:003324050.151
negative regulation of protein metabolic processGO:00512482820.149
regulation of ion transportGO:00432692150.148
negative regulation of defense responseGO:0031348770.147
protein ubiquitinationGO:00165671710.147
regulation of cd4 positive alpha beta t cell activationGO:2000514240.144
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.142
regulation of cellular ketone metabolic processGO:0010565660.142
symbiosis encompassing mutualism through parasitismGO:0044403830.141
regulation of response to biotic stimulusGO:0002831380.141
heterocycle catabolic processGO:00467002800.140
positive regulation of necrotic cell deathGO:001094010.136
negative regulation of inflammatory responseGO:0050728610.136
cd8 positive alpha beta t cell extravasationGO:003569730.135
interspecies interaction between organismsGO:0044419830.134
production of molecular mediator of immune responseGO:00024401030.132
regulation of jnk cascadeGO:0046328620.131
positive regulation of transferase activityGO:00513471670.131
protein deacetylationGO:0006476320.130
positive regulation of alpha beta t cell activationGO:0046635390.128
protein oligomerizationGO:0051259670.128
wound healing involved in inflammatory responseGO:000224640.128
stress activated mapk cascadeGO:0051403800.127
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.126
macromolecule deacylationGO:0098732370.124
t cell receptor signaling pathwayGO:0050852460.124
macromolecule catabolic processGO:00090572810.123
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.123
protein modification by small protein conjugation or removalGO:00706472070.122
regulation of cytokine biosynthetic processGO:0042035590.121
positive regulation of cd4 positive alpha beta t cell differentiationGO:0043372140.121
cytoplasmic transportGO:00164822340.121
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.121
peptidyl serine modificationGO:0018209830.121
regulation of antibacterial peptide biosynthetic processGO:000280810.121
response to peptidoglycanGO:003249490.120
regulation of reactive oxygen species biosynthetic processGO:190342620.120
negative regulation of apoptotic signaling pathwayGO:20012341040.119
negative regulation of nf kappab transcription factor activityGO:0032088150.119
organophosphate catabolic processGO:00464342320.119
granulocyte chemotaxisGO:0071621390.118
regulation of apoptotic signaling pathwayGO:20012331970.118
response to interleukin 18GO:007067340.116
interferon beta biosynthetic processGO:004535040.116
purine containing compound metabolic processGO:00725213110.115
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.115
skin developmentGO:00435882200.115
regulation of t cell mediated immunityGO:0002709340.114
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.112
positive regulation of adaptive immune responseGO:0002821610.112
regulation of alpha beta t cell differentiationGO:0046637350.110
carbohydrate derivative biosynthetic processGO:19011371830.110
regulation of t cell proliferationGO:0042129920.110
organic cyclic compound catabolic processGO:19013612950.109
macrophage activationGO:0042116270.109
regulation of activated t cell proliferationGO:0046006160.109
alpha beta t cell proliferationGO:0046633210.107
t cell differentiation in thymusGO:0033077770.107
regulation of protein complex assemblyGO:0043254830.104
regulation of protein localizationGO:00328802310.104
regulation of inflammatory responseGO:00507271470.104
regulation of leukocyte mediated cytotoxicityGO:0001910380.104
regulation of b cell activationGO:0050864810.104
protein modification by small protein conjugationGO:00324461870.103
regulation of secretionGO:00510462740.102
response to exogenous dsrnaGO:0043330220.102
regulation of nucleotide metabolic processGO:00061401690.101
anion transportGO:00068201770.101
positive regulation of hydrolase activityGO:00513451480.100
t cell mediated immunityGO:0002456500.100
programmed necrotic cell deathGO:0097300280.099
regulation of erk1 and erk2 cascadeGO:0070372710.099
negative regulation of cell activationGO:00508661110.099
regulation of establishment of protein localizationGO:00702011810.098
ribonucleotide metabolic processGO:00092592910.097
leukocyte mediated immunityGO:00024431740.097
nucleotide binding domain leucine rich repeat containing receptor signaling pathwayGO:003587260.097
nucleobase containing small molecule metabolic processGO:00550863520.097
myeloid dendritic cell activationGO:0001773250.096
negative regulation of tumor necrosis factor productionGO:0032720170.095
regulation of body fluid levelsGO:00508781620.095
regulation of t helper 1 type immune responseGO:0002825170.095
nucleoside phosphate metabolic processGO:00067533380.094
lymphocyte homeostasisGO:0002260640.094
regulation of endothelial cell apoptotic processGO:200035190.094
peptidyl serine autophosphorylationGO:003628910.093
positive regulation of t cell proliferationGO:0042102520.091
negative regulation of tumor necrosis factor superfamily cytokine productionGO:1903556170.091
purine ribonucleoside triphosphate metabolic processGO:00092052200.090
regulation of mapk cascadeGO:00434082480.088
phagocytosisGO:0006909660.088
regulation of type i interferon productionGO:0032479220.088
nitrogen compound transportGO:00717052710.088
reactive oxygen species biosynthetic processGO:190340980.087
negative regulation of endothelial cell apoptotic processGO:200035270.087
small gtpase mediated signal transductionGO:0007264970.087
negative regulation of multi organism processGO:0043901680.087
t cell homeostasisGO:0043029350.087
regulation of t cell apoptotic processGO:0070232280.087
positive regulation of chemokine biosynthetic processGO:004508060.086
cellular response to growth factor stimulusGO:00713631970.086
type i interferon signaling pathwayGO:0060337100.086
b 1 b cell homeostasisGO:000192240.086
negative regulation of t cell activationGO:0050868650.086
purine containing compound catabolic processGO:00725232130.086
cellular response to organic cyclic compoundGO:0071407870.086
response to molecule of fungal originGO:000223840.085
ras protein signal transductionGO:0007265770.085
leukocyte mediated cytotoxicityGO:0001909620.085
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.084
ribose phosphate metabolic processGO:00196932910.084
establishment of protein localization to organelleGO:00725941180.084
protein localization to organelleGO:00333651850.083
positive regulation of interferon beta biosynthetic processGO:004535930.083
protein secretionGO:00093061110.083
purine nucleotide metabolic processGO:00061633020.083
nuclear transportGO:00511691390.083
purine ribonucleoside metabolic processGO:00461282410.083
regulation of symbiosis encompassing mutualism through parasitismGO:0043903520.083
positive regulation of protein kinase activityGO:00458601440.082
regulation of production of molecular mediator of immune responseGO:0002700650.082
antibacterial peptide productionGO:000277820.081
intrinsic apoptotic signaling pathwayGO:00971931320.081
necrotic cell deathGO:0070265300.081
amine metabolic processGO:0009308450.081
positive regulation of cellular catabolic processGO:00313311480.080
t cell mediated cytotoxicityGO:0001913260.080
angiogenesisGO:00015252010.080
positive regulation of t helper 1 type immune responseGO:0002827120.080
nucleocytoplasmic transportGO:00069131390.079
antimicrobial peptide biosynthetic processGO:000277720.078
toll like receptor 9 signaling pathwayGO:003416260.078
positive regulation of proteolysisGO:0045862850.078
regulation of defense response to virusGO:0050688180.078
gland developmentGO:00487323300.077
regulation of ion transmembrane transportGO:00347651190.076
cellular nitrogen compound catabolic processGO:00442702800.076
regulation of defense response to virus by hostGO:005069180.076
negative regulation of protein phosphorylationGO:00019331260.075
transmembrane transportGO:00550854120.074
antibacterial peptide biosynthetic processGO:000278020.074
negative regulation of interleukin 2 productionGO:003270380.073
response to radiationGO:00093141650.073
single organism nuclear importGO:1902593950.073
nucleotide metabolic processGO:00091173320.073
regulation of kinase activityGO:00435492490.073
response to lipoteichoic acidGO:007039160.073
viral processGO:0016032410.072
inflammatory response to woundingGO:009059440.071
regulation of lipopolysaccharide mediated signaling pathwayGO:003166490.070
osteoclast differentiationGO:0030316620.069
protein autophosphorylationGO:0046777610.069
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.069
purine nucleotide catabolic processGO:00061952110.069
compound eye developmentGO:004874910.068
regulation of antimicrobial peptide productionGO:000278410.068
g protein coupled receptor signaling pathwayGO:00071862430.068
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.068
cell killingGO:0001906670.068
b cell mediated immunityGO:0019724710.068
protein localization to nucleusGO:00345041210.067
negative regulation of molecular functionGO:00440922580.067
regulation of protein modification by small protein conjugation or removalGO:1903320570.067
negative regulation of protein modification processGO:00314001630.067
spleen developmentGO:0048536390.066
carbohydrate derivative catabolic processGO:19011362310.066
positive regulation of nucleotide catabolic processGO:0030813880.066
regulation of lymphocyte mediated immunityGO:0002706840.065
regulation of cd8 positive alpha beta t cell extravasationGO:200044930.065
antigen processing and presentationGO:0019882470.065
regulation of hydrolase activityGO:00513362460.065
positive regulation of secretion by cellGO:19035321140.065
positive regulation of nucleotide metabolic processGO:00459811140.065
antibacterial humoral responseGO:001973180.065
posttranscriptional regulation of gene expressionGO:00106081550.064
regulation of organelle organizationGO:00330432890.064
negative regulation of sequence specific dna binding transcription factor activityGO:0043433400.064
response to type i interferonGO:0034340120.063
protein catabolic processGO:00301632210.063
purine nucleoside triphosphate metabolic processGO:00091442260.063
lipid biosynthetic processGO:00086101790.062
purine ribonucleoside triphosphate catabolic processGO:00092071990.062
negative regulation of interleukin 6 productionGO:0032715170.062
immunoglobulin mediated immune responseGO:0016064690.061
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244250.061
positive regulation of cd4 positive alpha beta t cell activationGO:2000516160.061
engulfment of apoptotic cellGO:004365230.061
regulation of vitamin d biosynthetic processGO:006055610.060
negative regulation of toll like receptor signaling pathwayGO:0034122140.060
aromatic compound catabolic processGO:00194392860.060
regulation of nucleotide binding oligomerization domain containing signaling pathwayGO:007042430.060
purine ribonucleotide metabolic processGO:00091502900.059
negative regulation of cellular amino acid metabolic processGO:004576300.059
regulation of nucleocytoplasmic transportGO:0046822730.059
regulation of t cell extravasationGO:200040730.058
regulation of intracellular protein transportGO:0033157820.058
intracellular protein transportGO:00068862040.058
glycosyl compound catabolic processGO:19016582060.058
toll like receptor 2 signaling pathwayGO:003413460.058
regulation of anion transportGO:0044070270.058
regulation of t cell mediated cytotoxicityGO:0001914180.058
regionalizationGO:00030023370.057
positive regulation of antibacterial peptide biosynthetic processGO:000696310.057
glycosyl compound metabolic processGO:19016572460.057
regulation of cytoplasmic transportGO:19036491120.057
nucleoside triphosphate metabolic processGO:00091412300.056
purine nucleoside catabolic processGO:00061522050.056
positive regulation of interferon beta productionGO:003272880.056
response to light stimulusGO:00094161350.056
positive regulation of cysteine type endopeptidase activityGO:2001056390.056
immune response activating cell surface receptor signaling pathwayGO:0002429720.056
nitric oxide metabolic processGO:0046209250.055
cellular response to dna damage stimulusGO:00069742070.055
muscle tissue developmentGO:00605373080.055
macrophage differentiationGO:0030225200.054
protein maturationGO:00516041760.054
erk1 and erk2 cascadeGO:0070371770.053
positive regulation of leukocyte proliferationGO:0070665730.053
nucleotide catabolic processGO:00091662170.052
positive regulation of reactive oxygen species biosynthetic processGO:190342820.052
positive regulation of macrophage activationGO:0043032100.052
immunoglobulin productionGO:0002377730.052
response to peptideGO:19016521360.052
regulation of neuron differentiationGO:00456642810.051
protein import into nucleusGO:0006606950.051
ribonucleotide catabolic processGO:00092612080.051
granulocyte migrationGO:0097530430.051
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.050
regulation of antimicrobial peptide biosynthetic processGO:000280510.050
positive regulation of nervous system developmentGO:00519622210.050
cellular response to peptideGO:1901653920.050
negative regulation of phosphorus metabolic processGO:00105631840.050
mucopolysaccharide metabolic processGO:1903510250.050
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238340.050
regulation of protein ubiquitinationGO:0031396520.049
regulation of purine nucleotide metabolic processGO:19005421690.049
purine nucleoside metabolic processGO:00422782410.048
positive regulation of myeloid leukocyte differentiationGO:0002763260.048
protein deacylationGO:0035601360.048
positive regulation of inflammatory responseGO:0050729470.047
natural killer cell activationGO:0030101440.047
interleukin 1 productionGO:0032612310.047
membrane organizationGO:00610242450.047
positive regulation of purine nucleotide metabolic processGO:19005441140.047
blood circulationGO:00080151950.047
response to growth factorGO:00708481980.047
regulation of protein serine threonine kinase activityGO:00719001570.047
regulation of macrophage activationGO:0043030170.046
cation homeostasisGO:00550802120.046
toxin transportGO:1901998380.046
positive regulation of protein transportGO:0051222930.046
negative regulation of t cell proliferationGO:0042130380.046
regulation of cd4 positive alpha beta t cell differentiationGO:0043370210.046
blood vessel morphogenesisGO:00485142850.045
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.045
activation induced cell death of t cellsGO:0006924100.045
3 utr mediated mrna stabilizationGO:007093520.045
organonitrogen compound catabolic processGO:19015652640.045
regulation of interleukin 23 productionGO:003266720.045
peptidyl tyrosine modificationGO:00182121450.044
positive regulation of necroptotic processGO:006054510.044
regulation of alpha beta t cell proliferationGO:0046640180.044
rho protein signal transductionGO:0007266320.044
cellular carbohydrate metabolic processGO:00442621190.043
myd88 dependent toll like receptor signaling pathwayGO:000275570.043
positive regulation of secretionGO:00510471300.043
response to peptide hormoneGO:00434341270.043
positive regulation of protein deacetylationGO:009031290.042
regulation of oxidoreductase activityGO:0051341150.042
cellular macromolecule catabolic processGO:00442652060.042
ribonucleoside triphosphate metabolic processGO:00091992200.042
positive regulation of production of molecular mediator of immune responseGO:0002702450.042
regulation of type i interferon mediated signaling pathwayGO:006033870.041
regulation of nitric oxide biosynthetic processGO:0045428180.041
ribonucleoside catabolic processGO:00424542060.041
regulation of cellular component biogenesisGO:00440871810.041
amide transportGO:00428861380.040
regulation of interferon beta productionGO:0032648130.040
organonitrogen compound biosynthetic processGO:19015661920.040
peptidyl serine phosphorylationGO:0018105740.040
rhythmic processGO:00485111740.040
protein targetingGO:00066051430.040
regulation of endopeptidase activityGO:0052548890.039
positive regulation of cellular amino acid metabolic processGO:004576430.039
blood coagulationGO:0007596760.039
negative regulation of necroptotic processGO:006054690.038
polysaccharide metabolic processGO:0005976390.038
regulation of antibacterial peptide productionGO:000278610.038

Map3k8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.277
Human
disease of cellular proliferationDOID:1456600.277
Human
organ system cancerDOID:005068600.148
Human