IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Map3k8

mitogen-activated protein kinase kinase kinase 8

(Aliases: Estf,Est,Cot,Tpl-2,Tpl2,Cot/Tpl2,c-COT)

Ensembl: ENSMUSG00000024235
Entrez: 26410
UniProtKB: Q3UEB8
UniProtKB: Q07174

Process Predictions
Disease Predictions

Map3k8 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
activation of innate immune response	GO:0002218	56	0.998
toll like receptor signaling pathway	GO:0002224	38	0.997
positive regulation of innate immune response	GO:0045089	80	0.994
cytoplasmic pattern recognition receptor signaling pathway	GO:0002753	10	0.988
response to interleukin 12	GO:0070671	2	0.987
activation of immune response	GO:0002253	138	0.985
immune response activating signal transduction	GO:0002757	116	0.984
cellular response to molecule of bacterial origin	GO:0071219	83	0.980
cellular response to biotic stimulus	GO:0071216	92	0.979
regulation of innate immune response	GO:0045088	91	0.976
pattern recognition receptor signaling pathway	GO:0002221	47	0.971
cellular response to lipopolysaccharide	GO:0071222	77	0.959
cytokine production	GO:0001816	319	0.958
cytokine mediated signaling pathway	GO:0019221	115	0.956
regulation of defense response	GO:0031347	233	0.954
cellular response to cytokine stimulus	GO:0071345	189	0.953
i kappab kinase nf kappab signaling	GO:0007249	85	0.946
innate immune response activating signal transduction	GO:0002758	50	0.942
immune response regulating signaling pathway	GO:0002764	125	0.924
innate immune response	GO:0045087	157	0.917
positive regulation of defense response	GO:0031349	124	0.903
tumor necrosis factor production	GO:0032640	50	0.899
regulation of chemokine production	GO:0032642	30	0.887
regulation of tumor necrosis factor production	GO:0032680	49	0.886
positive regulation of cytokine production	GO:0001819	174	0.883
nucleotide binding oligomerization domain containing signaling pathway	GO:0070423	6	0.878
response to lipopolysaccharide	GO:0032496	128	0.857
regulation of cd8 positive alpha beta cytotoxic t cell extravasation	GO:2000452	2	0.850
regulation of cytokine production	GO:0001817	266	0.836
response to molecule of bacterial origin	GO:0002237	143	0.831
regulation of lymphocyte activation	GO:0051249	240	0.815
regulation of interleukin 6 production	GO:0032675	55	0.789
regulation of interleukin 8 production	GO:0032677	3	0.788
regulation of cell activation	GO:0050865	289	0.784
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.784
defense response to other organism	GO:0098542	197	0.778
defense response to virus	GO:0051607	68	0.762
ripoptosome assembly involved in necroptotic process	GO:1901026	6	0.737
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.704
positive regulation of cell activation	GO:0050867	158	0.702
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.689
response to interleukin 1	GO:0070555	11	0.680
nucleotide binding oligomerization domain containing 1 signaling pathway	GO:0070427	5	0.674
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.663
cellular response to lipid	GO:0071396	145	0.657
positive regulation of interleukin 8 production	GO:0032757	2	0.654
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.648
positive regulation of chemokine production	GO:0032722	22	0.639
positive regulation of lymphocyte activation	GO:0051251	140	0.634
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.631
positive regulation of t helper 1 cell differentiation	GO:0045627	4	0.630
interleukin 8 production	GO:0032637	4	0.596
t helper cell differentiation	GO:0042093	28	0.588
immune effector process	GO:0002252	321	0.588
positive regulation of tumor necrosis factor production	GO:0032760	30	0.585
alpha beta t cell activation involved in immune response	GO:0002287	31	0.580
t cell activation involved in immune response	GO:0002286	43	0.575
regulation of necroptotic process	GO:0060544	10	0.572
chemokine production	GO:0032602	34	0.569
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.564
inflammatory response	GO:0006954	244	0.564
cytokine metabolic process	GO:0042107	71	0.548
cell activation involved in immune response	GO:0002263	126	0.547
negative regulation of immune system process	GO:0002683	209	0.542
cellular response to peptidoglycan	GO:0071224	4	0.532
lymphocyte differentiation	GO:0030098	242	0.529
negative regulation of cytokine production	GO:0001818	84	0.525
positive regulation of response to cytokine stimulus	GO:0060760	11	0.521
peptidyl amino acid modification	GO:0018193	336	0.499
t cell activation	GO:0042110	289	0.494
positive regulation of t cell differentiation	GO:0045582	52	0.485
positive regulation of immature t cell proliferation	GO:0033091	4	0.461
cd4 positive alpha beta t cell activation	GO:0035710	45	0.450
regulation of leukocyte differentiation	GO:1902105	159	0.448
positive regulation of lymphocyte differentiation	GO:0045621	61	0.447
adaptive immune response	GO:0002250	155	0.444
cellular response to organonitrogen compound	GO:0071417	145	0.441
intracellular receptor signaling pathway	GO:0030522	74	0.436
t cell apoptotic process	GO:0070231	39	0.432
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.427
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.425
leukocyte activation involved in immune response	GO:0002366	126	0.420
t cell differentiation involved in immune response	GO:0002292	30	0.414
positive regulation of apoptotic process	GO:0043065	217	0.410
lipopolysaccharide mediated signaling pathway	GO:0031663	25	0.409
regulation of transferase activity	GO:0051338	263	0.404
positive regulation of interferon alpha production	GO:0032727	4	0.402
jnk cascade	GO:0007254	72	0.396
regulation of cellular amino acid metabolic process	GO:0006521	5	0.395
regulation of leukocyte proliferation	GO:0070663	121	0.394
regulation of defense response to fungus	GO:1900150	1	0.386
defense response to gram positive bacterium	GO:0050830	50	0.386
mapk cascade	GO:0000165	281	0.382
alpha beta t cell differentiation	GO:0046632	69	0.381
myeloid leukocyte activation	GO:0002274	83	0.379
type i interferon production	GO:0032606	29	0.377
response to organic cyclic compound	GO:0014070	198	0.376
homeostasis of number of cells	GO:0048872	210	0.368
toll like receptor 4 signaling pathway	GO:0034142	9	0.367
cell type specific apoptotic process	GO:0097285	268	0.366
positive regulation of nf kappab transcription factor activity	GO:0051092	30	0.351
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.349
t helper 1 cell differentiation	GO:0045063	13	0.348
nik nf kappab signaling	GO:0038061	14	0.348
regulation of interferon gamma production	GO:0032649	57	0.344
positive regulation of type i interferon production	GO:0032481	14	0.340
t helper 1 type immune response	GO:0042088	25	0.335
positive regulation of antimicrobial peptide production	GO:0002225	1	0.333
regulation of lymphocyte apoptotic process	GO:0070228	41	0.330
defense response to bacterium	GO:0042742	119	0.329
positive regulation of protein modification process	GO:0031401	299	0.321
positive regulation of programmed cell death	GO:0043068	218	0.316
nucleotide binding oligomerization domain containing 2 signaling pathway	GO:0070431	6	0.316
positive regulation of immune effector process	GO:0002699	107	0.312
antigen receptor mediated signaling pathway	GO:0050851	64	0.310
interleukin 6 production	GO:0032635	58	0.308
apoptotic signaling pathway	GO:0097190	306	0.300
positive regulation of stress activated mapk cascade	GO:0032874	48	0.298
toll like receptor 3 signaling pathway	GO:0034138	4	0.296
lymphocyte proliferation	GO:0046651	164	0.293
leukocyte migration	GO:0050900	124	0.288
regulation of toll like receptor signaling pathway	GO:0034121	20	0.278
reactive oxygen species metabolic process	GO:0072593	84	0.275
positive regulation of mapk cascade	GO:0043410	170	0.271
cellular ketone metabolic process	GO:0042180	84	0.269
positive regulation of cell death	GO:0010942	224	0.268
cellular amino acid metabolic process	GO:0006520	103	0.267
t cell proliferation	GO:0042098	120	0.266
regulation of interleukin 2 production	GO:0032663	28	0.265
antimicrobial peptide production	GO:0002775	2	0.260
necroptotic process	GO:0070266	21	0.259
carbohydrate metabolic process	GO:0005975	230	0.258
lymphocyte apoptotic process	GO:0070227	54	0.257
interferon gamma production	GO:0032609	67	0.256
regulation of t cell activation	GO:0050863	170	0.253
leukocyte proliferation	GO:0070661	172	0.247
positive regulation of interleukin 6 production	GO:0032755	37	0.241
positive regulation of type i interferon mediated signaling pathway	GO:0060340	4	0.239
regulation of response to cytokine stimulus	GO:0060759	23	0.237
b cell activation	GO:0042113	161	0.234
leukocyte differentiation	GO:0002521	342	0.232
reactive nitrogen species metabolic process	GO:2001057	0	0.231
regulation of t helper 1 cell differentiation	GO:0045625	7	0.231
positive regulation of lymphocyte proliferation	GO:0050671	70	0.228
regulation of leukocyte apoptotic process	GO:2000106	56	0.228
regulation of stress activated mapk cascade	GO:0032872	69	0.223
regulation of t cell differentiation	GO:0045580	83	0.222
negative regulation of phosphate metabolic process	GO:0045936	184	0.220
response to dsrna	GO:0043331	30	0.218
regulation of response to wounding	GO:1903034	189	0.218
regulation of defense response to bacterium	GO:1900424	3	0.213
stress activated protein kinase signaling cascade	GO:0031098	81	0.212
regulation of protein kinase activity	GO:0045859	232	0.211
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway	GO:0070428	3	0.211
regulation of necrotic cell death	GO:0010939	13	0.209
positive regulation of leukocyte differentiation	GO:1902107	86	0.208
myeloid cell differentiation	GO:0030099	233	0.208
regulation of interferon beta biosynthetic process	GO:0045357	4	0.206
negative regulation of lymphocyte activation	GO:0051250	91	0.205
interleukin 2 production	GO:0032623	33	0.205
alpha beta t cell activation	GO:0046631	91	0.205
leukocyte homeostasis	GO:0001776	79	0.204
regulation of cellular catabolic process	GO:0031329	242	0.203
interferon beta production	GO:0032608	16	0.202
lymphocyte activation involved in immune response	GO:0002285	93	0.202
regulation of multi organism process	GO:0043900	111	0.199
t cell differentiation	GO:0030217	174	0.199
regulation of adaptive immune response	GO:0002819	90	0.198
regulation of protein transport	GO:0051223	163	0.198
cellular amine metabolic process	GO:0044106	44	0.197
extrinsic apoptotic signaling pathway	GO:0097191	126	0.195
response to organonitrogen compound	GO:0010243	246	0.194
wound healing	GO:0042060	157	0.191
positive regulation of jnk cascade	GO:0046330	46	0.190
lymphocyte mediated immunity	GO:0002449	139	0.188
regulation of lymphocyte proliferation	GO:0050670	117	0.185
negative regulation of cell proliferation	GO:0008285	296	0.185
peptidyl tyrosine phosphorylation	GO:0018108	143	0.185
regulation of cellular response to stress	GO:0080135	159	0.184
interleukin 1 mediated signaling pathway	GO:0070498	4	0.182
t cell extravasation	GO:0072683	4	0.181
negative regulation of cellular protein metabolic process	GO:0032269	247	0.181
positive regulation of alpha beta t cell differentiation	GO:0046638	28	0.181
regulation of antimicrobial humoral response	GO:0002759	3	0.180
negative regulation of intracellular signal transduction	GO:1902532	167	0.180
positive regulation of interferon gamma production	GO:0032729	39	0.179
positive regulation of t cell activation	GO:0050870	101	0.178
positive regulation of antimicrobial humoral response	GO:0002760	2	0.176
regulation of cytokine production involved in immune response	GO:0002718	26	0.172
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.171
regulation of cell killing	GO:0031341	40	0.169
regulation of alpha beta t cell activation	GO:0046634	53	0.167
regulation of protein deacetylation	GO:0090311	17	0.166
interleukin 18 mediated signaling pathway	GO:0035655	2	0.166
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.165
regulation of cellular amine metabolic process	GO:0033238	20	0.164
leukocyte apoptotic process	GO:0071887	71	0.162
toll like receptor 7 signaling pathway	GO:0034154	4	0.160
regulation of cell migration	GO:0030334	219	0.160
regulation of secretion by cell	GO:1903530	249	0.160
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.159
cd8 positive alpha beta cytotoxic t cell extravasation	GO:0035698	2	0.159
regulation of cell motility	GO:2000145	236	0.157
positive regulation of protein phosphorylation	GO:0001934	242	0.155
regulation of lymphocyte differentiation	GO:0045619	107	0.155
cytokine biosynthetic process	GO:0042089	68	0.154
myeloid leukocyte differentiation	GO:0002573	119	0.152
regulation of leukocyte mediated immunity	GO:0002703	104	0.152
positive regulation of cellular amine metabolic process	GO:0033240	5	0.151
negative regulation of protein metabolic process	GO:0051248	282	0.149
regulation of ion transport	GO:0043269	215	0.148
negative regulation of defense response	GO:0031348	77	0.147
protein ubiquitination	GO:0016567	171	0.147
regulation of cd4 positive alpha beta t cell activation	GO:2000514	24	0.144
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.142
regulation of cellular ketone metabolic process	GO:0010565	66	0.142
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.141
regulation of response to biotic stimulus	GO:0002831	38	0.141
heterocycle catabolic process	GO:0046700	280	0.140
positive regulation of necrotic cell death	GO:0010940	1	0.136
negative regulation of inflammatory response	GO:0050728	61	0.136
cd8 positive alpha beta t cell extravasation	GO:0035697	3	0.135
interspecies interaction between organisms	GO:0044419	83	0.134
production of molecular mediator of immune response	GO:0002440	103	0.132
regulation of jnk cascade	GO:0046328	62	0.131
positive regulation of transferase activity	GO:0051347	167	0.131
protein deacetylation	GO:0006476	32	0.130
positive regulation of alpha beta t cell activation	GO:0046635	39	0.128
protein oligomerization	GO:0051259	67	0.128
wound healing involved in inflammatory response	GO:0002246	4	0.128
stress activated mapk cascade	GO:0051403	80	0.127
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.126
macromolecule deacylation	GO:0098732	37	0.124
t cell receptor signaling pathway	GO:0050852	46	0.124
macromolecule catabolic process	GO:0009057	281	0.123
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.123
protein modification by small protein conjugation or removal	GO:0070647	207	0.122
regulation of cytokine biosynthetic process	GO:0042035	59	0.121
positive regulation of cd4 positive alpha beta t cell differentiation	GO:0043372	14	0.121
cytoplasmic transport	GO:0016482	234	0.121
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.121
peptidyl serine modification	GO:0018209	83	0.121
regulation of antibacterial peptide biosynthetic process	GO:0002808	1	0.121
response to peptidoglycan	GO:0032494	9	0.120
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.120
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.119
negative regulation of nf kappab transcription factor activity	GO:0032088	15	0.119
organophosphate catabolic process	GO:0046434	232	0.119
granulocyte chemotaxis	GO:0071621	39	0.118
regulation of apoptotic signaling pathway	GO:2001233	197	0.118
response to interleukin 18	GO:0070673	4	0.116
interferon beta biosynthetic process	GO:0045350	4	0.116
purine containing compound metabolic process	GO:0072521	311	0.115
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.115
skin development	GO:0043588	220	0.115
regulation of t cell mediated immunity	GO:0002709	34	0.114
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.112
positive regulation of adaptive immune response	GO:0002821	61	0.112
regulation of alpha beta t cell differentiation	GO:0046637	35	0.110
carbohydrate derivative biosynthetic process	GO:1901137	183	0.110
regulation of t cell proliferation	GO:0042129	92	0.110
organic cyclic compound catabolic process	GO:1901361	295	0.109
macrophage activation	GO:0042116	27	0.109
regulation of activated t cell proliferation	GO:0046006	16	0.109
alpha beta t cell proliferation	GO:0046633	21	0.107
t cell differentiation in thymus	GO:0033077	77	0.107
regulation of protein complex assembly	GO:0043254	83	0.104
regulation of protein localization	GO:0032880	231	0.104
regulation of inflammatory response	GO:0050727	147	0.104
regulation of leukocyte mediated cytotoxicity	GO:0001910	38	0.104
regulation of b cell activation	GO:0050864	81	0.104
protein modification by small protein conjugation	GO:0032446	187	0.103
regulation of secretion	GO:0051046	274	0.102
response to exogenous dsrna	GO:0043330	22	0.102
regulation of nucleotide metabolic process	GO:0006140	169	0.101
anion transport	GO:0006820	177	0.101
positive regulation of hydrolase activity	GO:0051345	148	0.100
t cell mediated immunity	GO:0002456	50	0.100
programmed necrotic cell death	GO:0097300	28	0.099
regulation of erk1 and erk2 cascade	GO:0070372	71	0.099
negative regulation of cell activation	GO:0050866	111	0.099
regulation of establishment of protein localization	GO:0070201	181	0.098
ribonucleotide metabolic process	GO:0009259	291	0.097
leukocyte mediated immunity	GO:0002443	174	0.097
nucleotide binding domain leucine rich repeat containing receptor signaling pathway	GO:0035872	6	0.097
nucleobase containing small molecule metabolic process	GO:0055086	352	0.097
myeloid dendritic cell activation	GO:0001773	25	0.096
negative regulation of tumor necrosis factor production	GO:0032720	17	0.095
regulation of body fluid levels	GO:0050878	162	0.095
regulation of t helper 1 type immune response	GO:0002825	17	0.095
nucleoside phosphate metabolic process	GO:0006753	338	0.094
lymphocyte homeostasis	GO:0002260	64	0.094
regulation of endothelial cell apoptotic process	GO:2000351	9	0.094
peptidyl serine autophosphorylation	GO:0036289	1	0.093
positive regulation of t cell proliferation	GO:0042102	52	0.091
negative regulation of tumor necrosis factor superfamily cytokine production	GO:1903556	17	0.091
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.090
regulation of mapk cascade	GO:0043408	248	0.088
phagocytosis	GO:0006909	66	0.088
regulation of type i interferon production	GO:0032479	22	0.088
nitrogen compound transport	GO:0071705	271	0.088
reactive oxygen species biosynthetic process	GO:1903409	8	0.087
negative regulation of endothelial cell apoptotic process	GO:2000352	7	0.087
small gtpase mediated signal transduction	GO:0007264	97	0.087
negative regulation of multi organism process	GO:0043901	68	0.087
t cell homeostasis	GO:0043029	35	0.087
regulation of t cell apoptotic process	GO:0070232	28	0.087
positive regulation of chemokine biosynthetic process	GO:0045080	6	0.086
cellular response to growth factor stimulus	GO:0071363	197	0.086
type i interferon signaling pathway	GO:0060337	10	0.086
b 1 b cell homeostasis	GO:0001922	4	0.086
negative regulation of t cell activation	GO:0050868	65	0.086
purine containing compound catabolic process	GO:0072523	213	0.086
cellular response to organic cyclic compound	GO:0071407	87	0.086
response to molecule of fungal origin	GO:0002238	4	0.085
ras protein signal transduction	GO:0007265	77	0.085
leukocyte mediated cytotoxicity	GO:0001909	62	0.085
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	34	0.084
ribose phosphate metabolic process	GO:0019693	291	0.084
establishment of protein localization to organelle	GO:0072594	118	0.084
protein localization to organelle	GO:0033365	185	0.083
positive regulation of interferon beta biosynthetic process	GO:0045359	3	0.083
protein secretion	GO:0009306	111	0.083
purine nucleotide metabolic process	GO:0006163	302	0.083
nuclear transport	GO:0051169	139	0.083
purine ribonucleoside metabolic process	GO:0046128	241	0.083
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.083
positive regulation of protein kinase activity	GO:0045860	144	0.082
regulation of production of molecular mediator of immune response	GO:0002700	65	0.082
antibacterial peptide production	GO:0002778	2	0.081
intrinsic apoptotic signaling pathway	GO:0097193	132	0.081
necrotic cell death	GO:0070265	30	0.081
amine metabolic process	GO:0009308	45	0.081
positive regulation of cellular catabolic process	GO:0031331	148	0.080
t cell mediated cytotoxicity	GO:0001913	26	0.080
angiogenesis	GO:0001525	201	0.080
positive regulation of t helper 1 type immune response	GO:0002827	12	0.080
nucleocytoplasmic transport	GO:0006913	139	0.079
antimicrobial peptide biosynthetic process	GO:0002777	2	0.078
toll like receptor 9 signaling pathway	GO:0034162	6	0.078
positive regulation of proteolysis	GO:0045862	85	0.078
regulation of defense response to virus	GO:0050688	18	0.078
gland development	GO:0048732	330	0.077
regulation of ion transmembrane transport	GO:0034765	119	0.076
cellular nitrogen compound catabolic process	GO:0044270	280	0.076
regulation of defense response to virus by host	GO:0050691	8	0.076
negative regulation of protein phosphorylation	GO:0001933	126	0.075
transmembrane transport	GO:0055085	412	0.074
antibacterial peptide biosynthetic process	GO:0002780	2	0.074
negative regulation of interleukin 2 production	GO:0032703	8	0.073
response to radiation	GO:0009314	165	0.073
single organism nuclear import	GO:1902593	95	0.073
nucleotide metabolic process	GO:0009117	332	0.073
regulation of kinase activity	GO:0043549	249	0.073
response to lipoteichoic acid	GO:0070391	6	0.073
viral process	GO:0016032	41	0.072
inflammatory response to wounding	GO:0090594	4	0.071
regulation of lipopolysaccharide mediated signaling pathway	GO:0031664	9	0.070
osteoclast differentiation	GO:0030316	62	0.069
protein autophosphorylation	GO:0046777	61	0.069
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.069
purine nucleotide catabolic process	GO:0006195	211	0.069
compound eye development	GO:0048749	1	0.068
regulation of antimicrobial peptide production	GO:0002784	1	0.068
g protein coupled receptor signaling pathway	GO:0007186	243	0.068
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.068
cell killing	GO:0001906	67	0.068
b cell mediated immunity	GO:0019724	71	0.068
protein localization to nucleus	GO:0034504	121	0.067
negative regulation of molecular function	GO:0044092	258	0.067
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.067
negative regulation of protein modification process	GO:0031400	163	0.067
spleen development	GO:0048536	39	0.066
carbohydrate derivative catabolic process	GO:1901136	231	0.066
positive regulation of nucleotide catabolic process	GO:0030813	88	0.066
regulation of lymphocyte mediated immunity	GO:0002706	84	0.065
regulation of cd8 positive alpha beta t cell extravasation	GO:2000449	3	0.065
antigen processing and presentation	GO:0019882	47	0.065
regulation of hydrolase activity	GO:0051336	246	0.065
positive regulation of secretion by cell	GO:1903532	114	0.065
positive regulation of nucleotide metabolic process	GO:0045981	114	0.065
antibacterial humoral response	GO:0019731	8	0.065
posttranscriptional regulation of gene expression	GO:0010608	155	0.064
regulation of organelle organization	GO:0033043	289	0.064
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.064
response to type i interferon	GO:0034340	12	0.063
protein catabolic process	GO:0030163	221	0.063
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.063
lipid biosynthetic process	GO:0008610	179	0.062
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.062
negative regulation of interleukin 6 production	GO:0032715	17	0.062
immunoglobulin mediated immune response	GO:0016064	69	0.061
positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	25	0.061
positive regulation of cd4 positive alpha beta t cell activation	GO:2000516	16	0.061
engulfment of apoptotic cell	GO:0043652	3	0.061
regulation of vitamin d biosynthetic process	GO:0060556	1	0.060
negative regulation of toll like receptor signaling pathway	GO:0034122	14	0.060
aromatic compound catabolic process	GO:0019439	286	0.060
regulation of nucleotide binding oligomerization domain containing signaling pathway	GO:0070424	3	0.060
purine ribonucleotide metabolic process	GO:0009150	290	0.059
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.059
regulation of nucleocytoplasmic transport	GO:0046822	73	0.059
regulation of t cell extravasation	GO:2000407	3	0.058
regulation of intracellular protein transport	GO:0033157	82	0.058
intracellular protein transport	GO:0006886	204	0.058
glycosyl compound catabolic process	GO:1901658	206	0.058
toll like receptor 2 signaling pathway	GO:0034134	6	0.058
regulation of anion transport	GO:0044070	27	0.058
regulation of t cell mediated cytotoxicity	GO:0001914	18	0.058
regionalization	GO:0003002	337	0.057
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	1	0.057
glycosyl compound metabolic process	GO:1901657	246	0.057
regulation of cytoplasmic transport	GO:1903649	112	0.057
nucleoside triphosphate metabolic process	GO:0009141	230	0.056
purine nucleoside catabolic process	GO:0006152	205	0.056
positive regulation of interferon beta production	GO:0032728	8	0.056
response to light stimulus	GO:0009416	135	0.056
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.056
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.056
nitric oxide metabolic process	GO:0046209	25	0.055
cellular response to dna damage stimulus	GO:0006974	207	0.055
muscle tissue development	GO:0060537	308	0.055
macrophage differentiation	GO:0030225	20	0.054
protein maturation	GO:0051604	176	0.054
erk1 and erk2 cascade	GO:0070371	77	0.053
positive regulation of leukocyte proliferation	GO:0070665	73	0.053
nucleotide catabolic process	GO:0009166	217	0.052
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.052
positive regulation of macrophage activation	GO:0043032	10	0.052
immunoglobulin production	GO:0002377	73	0.052
response to peptide	GO:1901652	136	0.052
regulation of neuron differentiation	GO:0045664	281	0.051
protein import into nucleus	GO:0006606	95	0.051
ribonucleotide catabolic process	GO:0009261	208	0.051
granulocyte migration	GO:0097530	43	0.051
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.050
regulation of antimicrobial peptide biosynthetic process	GO:0002805	1	0.050
positive regulation of nervous system development	GO:0051962	221	0.050
cellular response to peptide	GO:1901653	92	0.050
negative regulation of phosphorus metabolic process	GO:0010563	184	0.050
mucopolysaccharide metabolic process	GO:1903510	25	0.050
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.050
regulation of protein ubiquitination	GO:0031396	52	0.049
regulation of purine nucleotide metabolic process	GO:1900542	169	0.049
purine nucleoside metabolic process	GO:0042278	241	0.048
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.048
protein deacylation	GO:0035601	36	0.048
positive regulation of inflammatory response	GO:0050729	47	0.047
natural killer cell activation	GO:0030101	44	0.047
interleukin 1 production	GO:0032612	31	0.047
membrane organization	GO:0061024	245	0.047
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.047
blood circulation	GO:0008015	195	0.047
response to growth factor	GO:0070848	198	0.047
regulation of protein serine threonine kinase activity	GO:0071900	157	0.047
regulation of macrophage activation	GO:0043030	17	0.046
cation homeostasis	GO:0055080	212	0.046
toxin transport	GO:1901998	38	0.046
positive regulation of protein transport	GO:0051222	93	0.046
negative regulation of t cell proliferation	GO:0042130	38	0.046
regulation of cd4 positive alpha beta t cell differentiation	GO:0043370	21	0.046
blood vessel morphogenesis	GO:0048514	285	0.045
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.045
activation induced cell death of t cells	GO:0006924	10	0.045
3 utr mediated mrna stabilization	GO:0070935	2	0.045
organonitrogen compound catabolic process	GO:1901565	264	0.045
regulation of interleukin 23 production	GO:0032667	2	0.045
peptidyl tyrosine modification	GO:0018212	145	0.044
positive regulation of necroptotic process	GO:0060545	1	0.044
regulation of alpha beta t cell proliferation	GO:0046640	18	0.044
rho protein signal transduction	GO:0007266	32	0.044
cellular carbohydrate metabolic process	GO:0044262	119	0.043
myd88 dependent toll like receptor signaling pathway	GO:0002755	7	0.043
positive regulation of secretion	GO:0051047	130	0.043
response to peptide hormone	GO:0043434	127	0.043
positive regulation of protein deacetylation	GO:0090312	9	0.042
regulation of oxidoreductase activity	GO:0051341	15	0.042
cellular macromolecule catabolic process	GO:0044265	206	0.042
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.042
positive regulation of production of molecular mediator of immune response	GO:0002702	45	0.042
regulation of type i interferon mediated signaling pathway	GO:0060338	7	0.041
regulation of nitric oxide biosynthetic process	GO:0045428	18	0.041
ribonucleoside catabolic process	GO:0042454	206	0.041
regulation of cellular component biogenesis	GO:0044087	181	0.041
amide transport	GO:0042886	138	0.040
regulation of interferon beta production	GO:0032648	13	0.040
organonitrogen compound biosynthetic process	GO:1901566	192	0.040
peptidyl serine phosphorylation	GO:0018105	74	0.040
rhythmic process	GO:0048511	174	0.040
protein targeting	GO:0006605	143	0.040
regulation of endopeptidase activity	GO:0052548	89	0.039
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.039
blood coagulation	GO:0007596	76	0.039
negative regulation of necroptotic process	GO:0060546	9	0.038
polysaccharide metabolic process	GO:0005976	39	0.038
regulation of antibacterial peptide production	GO:0002786	1	0.038

Map3k8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
cancer	DOID:162	0.277	Human
disease of cellular proliferation	DOID:14566	0.277	Human
organ system cancer	DOID:0050686	0.148	Human

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