Mus musculus

14 known processes

Herc2

hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2

(Aliases: rjs,KIAA0393,jdf2,D7H15F32S1,D15F32S1h,mKIAA0393,D7H15F37S1)

Herc2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
male gamete generationGO:00482322850.072
cellular amino acid metabolic processGO:00065201030.056
spermatogenesisGO:00072832840.052
regulation of cellular amine metabolic processGO:0033238200.050
macromolecule catabolic processGO:00090572810.049
purine nucleotide metabolic processGO:00061633020.049
covalent chromatin modificationGO:00165691630.048
regulation of cellular amino acid metabolic processGO:000652150.047
protein modification by small protein conjugationGO:00324461870.046
Human
cation transmembrane transportGO:00986552660.044
peptidyl amino acid modificationGO:00181933360.044
protein catabolic processGO:00301632210.043
cellular protein catabolic processGO:00442571550.042
ubiquitin dependent protein catabolic processGO:00065111290.042
amine metabolic processGO:0009308450.040
protein modification by small protein conjugation or removalGO:00706472070.040
Human
endomembrane system organizationGO:00102561470.040
rhythmic processGO:00485111740.039
sequestering of calcium ionGO:0051208180.039
circadian rhythmGO:00076231140.039
cellular amine metabolic processGO:0044106440.039
nucleobase containing small molecule metabolic processGO:00550863520.038
negative regulation of cellular protein metabolic processGO:00322692470.037
cellular ketone metabolic processGO:0042180840.037
nucleotide metabolic processGO:00091173320.037
apoptotic signaling pathwayGO:00971903060.037
aromatic compound catabolic processGO:00194392860.036
nucleoside phosphate catabolic processGO:19012922220.035
cellular macromolecule catabolic processGO:00442652060.034
regulation of organelle organizationGO:00330432890.034
positive regulation of protein modification processGO:00314012990.034
positive regulation of cellular amine metabolic processGO:003324050.034
divalent inorganic cation transportGO:00725111780.034
sequestering of metal ionGO:0051238190.033
purine containing compound metabolic processGO:00725213110.033
cognitionGO:00508901490.033
chromatin organizationGO:00063252060.033
dna metabolic processGO:00062593030.032
Human
heterocycle catabolic processGO:00467002800.032
regulation of cellular ketone metabolic processGO:0010565660.032
ras protein signal transductionGO:0007265770.032
glycosyl compound metabolic processGO:19016572460.032
organic cyclic compound catabolic processGO:19013612950.032
positive regulation of cellular amino acid metabolic processGO:004576430.031
protein ubiquitinationGO:00165671710.031
Human
regulation of cell cycleGO:00517262810.030
inorganic cation transmembrane transportGO:00986622070.030
ribonucleoside catabolic processGO:00424542060.030
cellular nitrogen compound catabolic processGO:00442702800.029
actin cytoskeleton organizationGO:00300362200.029
negative regulation of protein metabolic processGO:00512482820.029
nucleoside phosphate metabolic processGO:00067533380.029
modification dependent protein catabolic processGO:00199411330.029
axonogenesisGO:00074092740.029
ribose phosphate metabolic processGO:00196932910.029
response to organonitrogen compoundGO:00102432460.028
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.028
cation transportGO:00068123990.027
ribonucleotide metabolic processGO:00092592910.027
purine nucleotide catabolic processGO:00061952110.027
purine ribonucleotide metabolic processGO:00091502900.027
positive regulation of cellular catabolic processGO:00313311480.027
proteolysis involved in cellular protein catabolic processGO:00516031470.027
memoryGO:0007613580.027
hematopoietic progenitor cell differentiationGO:00022441430.027
transmembrane transportGO:00550854120.026
regulation of cellular catabolic processGO:00313292420.026
synaptic transmissionGO:00072683290.026
protein maturationGO:00516041760.025
cellular response to dna damage stimulusGO:00069742070.025
Human
histone modificationGO:00165701590.025
small gtpase mediated signal transductionGO:0007264970.025
cellular ion homeostasisGO:00068731650.025
immune effector processGO:00022523210.025
learning or memoryGO:00076111480.025
dna repairGO:00062811070.025
Human
metal ion homeostasisGO:00550651890.024
ion transmembrane transportGO:00342203610.024
regionalizationGO:00030023370.024
carbohydrate derivative catabolic processGO:19011362310.024
regulation of system processGO:00440572000.024
purine nucleoside metabolic processGO:00422782410.023
purine containing compound catabolic processGO:00725232130.023
nucleoside triphosphate catabolic processGO:00091432050.023
nucleoside triphosphate metabolic processGO:00091412300.023
cellular metal ion homeostasisGO:00068751510.023
organelle localizationGO:00516401790.022
organonitrogen compound catabolic processGO:19015652640.022
extracellular matrix organizationGO:00301981470.022
organonitrogen compound biosynthetic processGO:19015661920.022
nucleoside catabolic processGO:00091642060.022
ribonucleoside triphosphate metabolic processGO:00091992200.022
cytoplasmic transportGO:00164822340.022
sensory perceptionGO:00076002450.021
regulation of chromatin modificationGO:1903308570.021
lateral inhibitionGO:004633110.021
regulation of chromosome organizationGO:0033044830.021
compound eye developmentGO:004874910.021
nucleoside metabolic processGO:00091162460.021
purine ribonucleoside catabolic processGO:00461302050.021
regulation of synaptic growth at neuromuscular junctionGO:000858240.021
modification dependent macromolecule catabolic processGO:00436321330.021
regulation of cellular component biogenesisGO:00440871810.021
cell adhesionGO:00071553290.021
cellular lipid metabolic processGO:00442553230.020
response to growth factorGO:00708481980.020
regulation of proteolysisGO:00301621640.020
divalent metal ion transportGO:00708381720.020
ribonucleotide catabolic processGO:00092612080.020
inorganic ion transmembrane transportGO:00986602340.020
actin filament polymerizationGO:0030041440.020
ribonucleoside metabolic processGO:00091192450.020
calcium ion transport into cytosolGO:0060402480.020
purine ribonucleoside triphosphate catabolic processGO:00092071990.020
learningGO:0007612980.020
purine nucleoside catabolic processGO:00061522050.020
cellular calcium ion homeostasisGO:00068741190.020
purine ribonucleotide catabolic processGO:00091542080.019
intracellular protein transportGO:00068862040.019
negative regulation of cellular amine metabolic processGO:003323910.019
vesicle localizationGO:0051648860.019
cellular homeostasisGO:00197252400.019
endocytosisGO:00068971680.019
membrane organizationGO:00610242450.019
calcium ion transmembrane transportGO:0070588850.018
regulation of apoptotic signaling pathwayGO:20012331970.018
rho protein signal transductionGO:0007266320.018
regulation of intracellular transportGO:00323861590.018
methylationGO:00322591340.018
posttranscriptional regulation of gene expressionGO:00106081550.018
regulation of reactive oxygen species metabolic processGO:2000377400.018
innate immune responseGO:00450871570.018
mitotic cytokinesisGO:000028140.018
regulation of reactive oxygen species biosynthetic processGO:190342620.018
cellular protein complex assemblyGO:00436231160.018
purine nucleoside triphosphate metabolic processGO:00091442260.018
reactive oxygen species metabolic processGO:0072593840.018
chromatin modificationGO:00165681870.018
regulation of cell cycle processGO:00105641600.018
response to radiationGO:00093141650.018
positive regulation of protein phosphorylationGO:00019342420.018
intrinsic apoptotic signaling pathwayGO:00971931320.017
regulation of membrane potentialGO:00423911920.017
cellular chemical homeostasisGO:00550822150.017
nuclear divisionGO:00002801580.017
regulation of voltage gated calcium channel activityGO:190138540.017
positive regulation of cell developmentGO:00107202370.017
microtubule cytoskeleton organization involved in mitosisGO:190285040.017
divalent inorganic cation homeostasisGO:00725071380.017
skeletal system developmentGO:00015013560.017
macromolecule methylationGO:00434141200.017
cation homeostasisGO:00550802120.017
carbohydrate metabolic processGO:00059752300.017
protein localization to membraneGO:00726571080.017
regulation of protein catabolic processGO:00421761080.017
microtubule cytoskeleton organizationGO:00002261570.017
microtubule based processGO:00070172360.017
regulation of transferase activityGO:00513382630.016
negative regulation of cellular component organizationGO:00511291940.016
glycosyl compound catabolic processGO:19016582060.016
cell growthGO:00160491300.016
protein localization to organelleGO:00333651850.016
purine nucleoside triphosphate catabolic processGO:00091462030.016
protein processingGO:00164851630.016
organophosphate catabolic processGO:00464342320.016
positive regulation of organelle organizationGO:00106381280.016
olfactory learningGO:000835520.016
regulation of cell motilityGO:20001452360.016
mitotic cell cycleGO:00002781950.016
cellular response to growth factor stimulusGO:00713631970.016
cellular response to organonitrogen compoundGO:00714171450.016
locomotory behaviorGO:00076261950.016
regulation of cell migrationGO:00303342190.016
establishment of organelle localizationGO:00516561220.016
leukocyte differentiationGO:00025213420.016
histone methylationGO:0016571710.016
cellular component assembly involved in morphogenesisGO:00109271390.015
dendrite developmentGO:00163581150.015
regulation of defense responseGO:00313472330.015
protein methylationGO:0006479810.015
fertilizationGO:00095661270.015
inflammatory responseGO:00069542440.015
spermatid differentiationGO:00485151150.015
organelle assemblyGO:00709251770.015
negative regulation of synapse assemblyGO:005196430.015
nitrogen compound transportGO:00717052710.015
regulation of hydrolase activityGO:00513362460.015
purine ribonucleoside triphosphate metabolic processGO:00092052200.015
purine ribonucleoside metabolic processGO:00461282410.015
myeloid cell differentiationGO:00300992330.015
regulation of purine nucleotide catabolic processGO:00331211220.015
neuromuscular processGO:0050905990.015
fat cell differentiationGO:00454441600.015
regulation of hormone levelsGO:00108172110.015
positive regulation of proteolysisGO:0045862850.015
nucleotide catabolic processGO:00091662170.015
multicellular organism growthGO:00352641610.015
translationGO:0006412930.015
calcium ion homeostasisGO:00550741270.015
mitotic cell cycle processGO:19030471590.015
action potentialGO:0001508780.015
oocyte axis specificationGO:000730920.015
reactive oxygen species biosynthetic processGO:190340980.014
negative regulation of protein phosphorylationGO:00019331260.014
peptidyl serine phosphorylationGO:0018105740.014
regulation of protein maturationGO:1903317960.014
wnt signaling pathwayGO:00160551880.014
ribonucleoside monophosphate metabolic processGO:0009161800.014
actin polymerization or depolymerizationGO:0008154540.014
regulation of ion homeostasisGO:2000021640.014
carbohydrate derivative biosynthetic processGO:19011371830.014
peptidyl serine modificationGO:0018209830.014
protein polymerizationGO:0051258570.014
response to endoplasmic reticulum stressGO:0034976530.014
cell type specific apoptotic processGO:00972852680.014
cell activation involved in immune responseGO:00022631260.014
negative regulation of cell proliferationGO:00082852960.014
glycoprotein metabolic processGO:00091001160.014
establishment of vesicle localizationGO:0051650810.014
organic anion transportGO:00157111370.013
positive regulation of reactive oxygen species biosynthetic processGO:190342820.013
release of sequestered calcium ion into cytosolGO:0051209420.013
regulation of cell adhesionGO:00301551540.013
striated muscle myosin thick filament assemblyGO:007168810.013
g protein coupled receptor signaling pathwayGO:00071862430.013
adult locomotory behaviorGO:0008344910.013
second messenger mediated signalingGO:0019932730.013
terminal button organizationGO:007255330.013
response to light stimulusGO:00094161350.013
ossificationGO:00015032160.013
embryonic organ morphogenesisGO:00485622760.013
positive regulation of nervous system developmentGO:00519622210.013
negative regulation of phosphorus metabolic processGO:00105631840.013
response to inorganic substanceGO:0010035960.013
cellular divalent inorganic cation homeostasisGO:00725031270.013
myeloid leukocyte activationGO:0002274830.013
maintenance of locationGO:0051235890.013
regulation of protein kinase activityGO:00458592320.013
microtubule based movementGO:0007018840.013
defecationGO:003042110.013
small molecule biosynthetic processGO:00442831320.013
negative regulation of protein modification processGO:00314001630.013
cell recognitionGO:0008037830.013
axon guidanceGO:00074111410.013
rna interferenceGO:001624620.013
germ cell developmentGO:00072811850.013
positive regulation of cell deathGO:00109422240.013
actin filament organizationGO:00070151130.013
regulation of protein processingGO:0070613960.013
cytosolic calcium ion transportGO:0060401480.013
cytosolic calcium ion homeostasisGO:0051480700.012
monocarboxylic acid metabolic processGO:00327871910.012
cellularizationGO:000734910.012
regulation of neurotransmitter levelsGO:0001505870.012
regulation of cytoskeleton organizationGO:00514931220.012
regulation of vesicle mediated transportGO:00606271390.012
regulation of inflammatory responseGO:00507271470.012
nucleoside monophosphate metabolic processGO:0009123850.012
regulation of feeding behaviorGO:006025930.012
respiratory system developmentGO:00605411900.012
cytokinetic processGO:003250620.012
cytokine mediated signaling pathwayGO:00192211150.012
atp metabolic processGO:0046034750.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.012
protein polyubiquitinationGO:0000209330.012
nuclear transportGO:00511691390.012
spermatid developmentGO:00072861080.012
actin filament based movementGO:0030048230.012
regulation of translationGO:0006417710.012
regulation of ion transmembrane transportGO:00347651190.012
negative regulation of proteolysisGO:0045861740.012
adult behaviorGO:00305341350.012
leukocyte activation involved in immune responseGO:00023661260.012
development of primary sexual characteristicsGO:00451371430.012
histone lysine methylationGO:0034968500.012
nucleocytoplasmic transportGO:00069131390.012
cilium morphogenesisGO:00602711020.012
circadian regulation of gene expressionGO:0032922480.012
gonad developmentGO:00084061410.012
ribonucleoside monophosphate catabolic processGO:0009158570.012
regulation of cellular component sizeGO:00325351210.012
protein autophosphorylationGO:0046777610.012
positive regulation of apoptotic processGO:00430652170.012
response to oxygen levelsGO:0070482620.012
regulation of circadian rhythmGO:0042752580.012
negative regulation of nervous system developmentGO:00519611560.012
single fertilizationGO:0007338820.012
organ growthGO:00352651170.012
mapk cascadeGO:00001652810.012
response to transforming growth factor betaGO:0071559880.012
cellular response to lipopolysaccharideGO:0071222770.012
protein alkylationGO:0008213810.012
ribonucleoside triphosphate catabolic processGO:00092031990.012
organic hydroxy compound metabolic processGO:19016152030.012
glycerophospholipid metabolic processGO:0006650710.012
positive regulation of cell adhesionGO:0045785800.012
cellular response to molecule of bacterial originGO:0071219830.012
purine nucleoside monophosphate metabolic processGO:0009126810.012
myosin filament organizationGO:003103330.012
regulation of kinase activityGO:00435492490.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.011
male courtship behaviorGO:000804920.011
regulation of protein complex assemblyGO:0043254830.011
extracellular structure organizationGO:00430621480.011
meiotic cell cycleGO:00513211220.011
anion transportGO:00068201770.011
negative regulation of phosphorylationGO:00423261660.011
negative regulation of cell migrationGO:0030336590.011
muscle system processGO:00030121410.011
regulation of cell substrate adhesionGO:0010810730.011
blood vessel morphogenesisGO:00485142850.011
regulation of histone modificationGO:0031056560.011
cytokine productionGO:00018163190.011
exocytosisGO:00068871210.011
negative regulation of molecular functionGO:00440922580.011
regulation of establishment of protein localizationGO:00702011810.011
engulfment of apoptotic cellGO:004365230.011
oocyte anterior posterior axis specificationGO:000731420.011
epithelial cell developmentGO:00020641590.011
muscle cell differentiationGO:00426922610.011
regulation of response to woundingGO:19030341890.011
regulation of cytoplasmic transportGO:19036491120.011
positive regulation of hydrolase activityGO:00513451480.011
reactive nitrogen species metabolic processGO:200105700.011
regulation of protein localizationGO:00328802310.011
positive regulation of programmed cell deathGO:00430682180.011
plasma membrane organizationGO:0007009900.011
positive regulation of reactive oxygen species metabolic processGO:2000379110.011
stem cell differentiationGO:00488632680.011
regulation of anatomical structure sizeGO:00900661780.011
cellular response to biotic stimulusGO:0071216920.011
positive regulation of transferase activityGO:00513471670.011
negative regulation of phosphate metabolic processGO:00459361840.011
proteasomal protein catabolic processGO:0010498980.011
macromolecule glycosylationGO:0043413550.011
cell substrate adhesionGO:00315891300.011
regulation of mapk cascadeGO:00434082480.011
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244250.010
organelle fissionGO:00482851700.010
regulation of ion transportGO:00432692150.010
phospholipid metabolic processGO:0006644870.010
synaptic vesicle localizationGO:0097479590.010
establishment of mitochondrion localizationGO:005165440.010
negative regulation of cell developmentGO:00107211690.010
calcium ion transportGO:00068161590.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.010
glycoprotein biosynthetic processGO:0009101890.010
cell divisionGO:00513011200.010
negative regulation of endothelial cell migrationGO:001059640.010
establishment of blood nerve barrierGO:000806530.010
regulation of cytokine productionGO:00018172660.010
positive regulation of cell cycleGO:0045787920.010
mrna metabolic processGO:0016071840.010
guanosine containing compound catabolic processGO:19010691440.010
synaptic vesicle transportGO:0048489570.010
cellular response to cytokine stimulusGO:00713451890.010
positive regulation of cell cycle processGO:0090068610.010
synapse organizationGO:00508081250.010
regulation of homeostatic processGO:00328441820.010
regulation of circadian sleep wake cycle sleepGO:004518730.010
protein oligomerizationGO:0051259670.010
purine ribonucleoside monophosphate catabolic processGO:0009169570.010
peptide hormone secretionGO:00300721090.010
positive regulation of neuron differentiationGO:00456661410.010

Herc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.045
nervous system diseaseDOID:86300.045
central nervous system diseaseDOID:33100.025
musculoskeletal system diseaseDOID:1700.025
immune system diseaseDOID:291400.017
cancerDOID:16200.015
disease of cellular proliferationDOID:1456600.015
organ system cancerDOID:005068600.015
muscle tissue diseaseDOID:6600.014
muscular diseaseDOID:008000000.014
connective tissue diseaseDOID:6500.014
neurodegenerative diseaseDOID:128900.013
hematopoietic system diseaseDOID:7400.011
disease of mental healthDOID:15000.010