Mus musculus

62 known processes

Plk4

polo-like kinase 4 (Drosophila)

(Aliases: Sak,1700028H20,Stk18,AI385771)

Plk4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
mitotic cell cycle processGO:19030471590.963
Fly
nuclear divisionGO:00002801580.945
Fly
mitotic cell cycleGO:00002781950.924
Fly
meiotic cell cycle processGO:1903046770.905
organelle fissionGO:00482851700.904
Fly
microtubule cytoskeleton organizationGO:00002261570.878
regulation of cell cycle processGO:00105641600.822
Human Fly
dna metabolic processGO:00062593030.805
microtubule based processGO:00070172360.738
gonad developmentGO:00084061410.689
meiosis iGO:0007127600.687
mitotic sister chromatid segregationGO:0000070140.674
mitotic chromosome condensationGO:000707610.655
meiotic cell cycleGO:00513211220.623
Fly
regulation of mitotic cell cycleGO:00073461260.613
mitotic nuclear divisionGO:0007067480.597
chromosome segregationGO:0007059480.565
centrosome organizationGO:0051297260.561
cellular response to dna damage stimulusGO:00069742070.548
regulation of cell cycleGO:00517262810.535
Human Fly
microtubule organizing center organizationGO:0031023280.522
regulation of mitosisGO:0007088290.466
spindle assembly involved in mitosisGO:009030740.458
female meiotic divisionGO:0007143210.444
dna packagingGO:0006323300.426
attachment of spindle microtubules to kinetochoreGO:000860840.420
spindle assemblyGO:0051225130.409
meiotic nuclear divisionGO:00071261150.408
Fly
chromosome organization involved in meiosisGO:0070192390.404
mitotic spindle organizationGO:0007052100.398
Fly
negative regulation of cell cycleGO:00457861230.362
sister chromatid segregationGO:0000819200.358
centrosome cycleGO:0007098230.339
regulation of cell divisionGO:0051302760.325
meiotic chromosome segregationGO:0045132190.321
regulation of spindle organizationGO:009022420.314
regulation of nuclear divisionGO:0051783560.313
cell cycle checkpointGO:0000075470.291
cell divisionGO:00513011200.287
dna recombinationGO:0006310920.281
dna conformation changeGO:0071103370.271
regulation of organelle organizationGO:00330432890.271
Human Fly
cellular macromolecule catabolic processGO:00442652060.270
organelle assemblyGO:00709251770.269
negative regulation of cellular component organizationGO:00511291940.268
regulation of microtubule based processGO:0032886520.262
Human Fly
male meiosisGO:0007140370.255
Fly
synapsisGO:0007129340.250
cellular protein catabolic processGO:00442571550.246
female meiosis chromosome segregationGO:001632110.242
regulation of mitotic cell cycle phase transitionGO:1901990730.237
ribonucleoside triphosphate catabolic processGO:00092031990.229
negative regulation of mitotic cell cycle phase transitionGO:1901991450.225
regulation of cellular catabolic processGO:00313292420.216
microtubule cytoskeleton organization involved in mitosisGO:190285040.213
centromere complex assemblyGO:003450830.199
male gamete generationGO:00482322850.198
Fly
dna replicationGO:0006260520.196
aromatic compound catabolic processGO:00194392860.191
double strand break repair via homologous recombinationGO:0000724210.190
spindle organizationGO:0007051280.181
Fly
nucleobase containing small molecule metabolic processGO:00550863520.179
regulation of attachment of spindle microtubules to kinetochoreGO:005198830.171
ribonucleoside triphosphate metabolic processGO:00091992200.165
development of primary sexual characteristicsGO:00451371430.165
centrosome separationGO:005129940.165
regulation of meiosis iGO:006063170.163
purine nucleotide metabolic processGO:00061633020.162
nucleic acid phosphodiester bond hydrolysisGO:0090305490.161
negative regulation of nuclear divisionGO:0051784190.158
mitotic cytokinesisGO:000028140.156
ubiquitin dependent protein catabolic processGO:00065111290.156
nucleoside triphosphate metabolic processGO:00091412300.155
double strand break repairGO:0006302480.153
glycosyl compound metabolic processGO:19016572460.150
ribose phosphate metabolic processGO:00196932910.146
intrinsic apoptotic signaling pathwayGO:00971931320.143
centrosome duplicationGO:0051298160.143
negative regulation of cell cycle phase transitionGO:1901988480.134
regulation of cell cycle phase transitionGO:1901987770.131
positive regulation of cell cycleGO:0045787920.131
Human
purine containing compound metabolic processGO:00725213110.131
nucleotide metabolic processGO:00091173320.129
mitotic sister chromatid separationGO:005130690.127
negative regulation of cell cycle processGO:0010948690.121
negative regulation of meiotic cell cycle phase transitionGO:190199430.121
negative regulation of mitotic cell cycleGO:0045930580.115
response to radiationGO:00093141650.111
nucleoside phosphate catabolic processGO:19012922220.111
protein catabolic processGO:00301632210.110
Fly
glycosyl compound catabolic processGO:19016582060.110
spindle assembly involved in meiosisGO:009030640.110
spindle assembly involved in female meiosisGO:000705630.105
establishment of organelle localizationGO:00516561220.104
rac protein signal transductionGO:0016601130.103
dna repairGO:00062811070.103
negative regulation of organelle organizationGO:0010639900.102
peptidyl amino acid modificationGO:00181933360.102
maintenance of locationGO:0051235890.101
organic cyclic compound catabolic processGO:19013612950.100
regulation of transferase activityGO:00513382630.100
nucleoside phosphate metabolic processGO:00067533380.096
carbohydrate derivative catabolic processGO:19011362310.096
developmental maturationGO:00217001930.094
purine nucleoside triphosphate catabolic processGO:00091462030.094
positive regulation of mitotic cell cycleGO:0045931410.093
purine nucleoside triphosphate metabolic processGO:00091442260.090
cellular nitrogen compound catabolic processGO:00442702800.089
ribonucleotide metabolic processGO:00092592910.089
positive regulation of nucleotide catabolic processGO:0030813880.086
purine ribonucleotide catabolic processGO:00091542080.086
chromosome separationGO:0051304140.085
regulation of purine nucleotide metabolic processGO:19005421690.085
genitalia developmentGO:0048806370.085
regulation of kinase activityGO:00435492490.085
ribonucleoside catabolic processGO:00424542060.085
cellular protein complex disassemblyGO:0043624360.084
negative regulation of cellular protein metabolic processGO:00322692470.084
positive regulation of nucleotide metabolic processGO:00459811140.083
regulation of cytoskeleton organizationGO:00514931220.082
Human Fly
regulation of nucleoside metabolic processGO:00091181300.082
regulation of chromosome segregationGO:0051983210.081
regulation of chromosome organizationGO:0033044830.080
negative regulation of meiotic cell cycleGO:0051447140.079
regulation of nucleotide metabolic processGO:00061401690.078
cellular response to ionizing radiationGO:0071479110.077
response to light stimulusGO:00094161350.074
nuclear dna replicationGO:003326030.073
positive regulation of gtp catabolic processGO:0033126850.073
negative regulation of proteolysisGO:0045861740.071
positive regulation of purine nucleotide metabolic processGO:19005441140.070
cellular ketone metabolic processGO:0042180840.070
microtubule based movementGO:0007018840.069
regulation of protein complex disassemblyGO:0043244280.069
macromolecule catabolic processGO:00090572810.069
Fly
nucleoside catabolic processGO:00091642060.069
protein localization to nucleusGO:00345041210.069
purine ribonucleotide metabolic processGO:00091502900.068
organophosphate catabolic processGO:00464342320.068
recombinational repairGO:0000725210.068
regulation of microtubule cytoskeleton organizationGO:0070507370.067
Human Fly
purine nucleoside metabolic processGO:00422782410.067
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434400.066
positive regulation of organelle organizationGO:00106381280.066
Human
nucleoside triphosphate catabolic processGO:00091432050.065
purine nucleoside catabolic processGO:00061522050.064
cellular amino acid metabolic processGO:00065201030.063
cellular response to abiotic stimulusGO:0071214560.063
reciprocal dna recombinationGO:0035825160.062
cellular response to radiationGO:0071478280.061
regulation of protein kinase activityGO:00458592320.059
cdc42 protein signal transductionGO:003248800.059
positive regulation of apoptotic processGO:00430652170.059
dna replication independent nucleosome assemblyGO:000633610.059
positive regulation of cellular catabolic processGO:00313311480.058
purine nucleotide catabolic processGO:00061952110.058
purine ribonucleoside metabolic processGO:00461282410.058
dna endoreduplicationGO:004202340.058
translesion synthesisGO:001998510.058
meiotic chromosome condensationGO:001003230.057
regulation of protein serine threonine kinase activityGO:00719001570.057
purine ribonucleoside triphosphate catabolic processGO:00092071990.056
positive regulation of hydrolase activityGO:00513451480.055
histone threonine phosphorylationGO:003540510.055
positive regulation of nucleoside metabolic processGO:0045979910.055
chromatin organizationGO:00063252060.055
microtubule anchoringGO:003445390.054
positive regulation of protein modification processGO:00314012990.054
regulation of protein maturationGO:1903317960.054
cellular response to organic cyclic compoundGO:0071407870.053
cytokinesisGO:0000910170.053
non recombinational repairGO:0000726100.053
organonitrogen compound catabolic processGO:19015652640.052
nucleoside metabolic processGO:00091162460.051
neural tube developmentGO:00219151600.051
regulation of proteasomal protein catabolic processGO:0061136460.051
oocyte maturationGO:0001556180.051
meiotic cytokinesisGO:003320650.050
regulation of cellular amine metabolic processGO:0033238200.050
amine metabolic processGO:0009308450.049
chromatin remodeling at centromereGO:003105520.049
covalent chromatin modificationGO:00165691630.049
chromatin modificationGO:00165681870.048
negative regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032435150.047
synaptonemal complex assemblyGO:0007130130.046
negative regulation of protein phosphorylationGO:00019331260.045
regulation of cellular ketone metabolic processGO:0010565660.045
receptor mediated endocytosisGO:0006898510.045
protein depolymerizationGO:0051261340.044
heterochromatin organizationGO:007082840.043
protein complex disassemblyGO:0043241400.043
cellular response to organonitrogen compoundGO:00714171450.042
cellular amine metabolic processGO:0044106440.042
proteolysis involved in cellular protein catabolic processGO:00516031470.042
negative regulation of microtubule polymerization or depolymerizationGO:0031111150.041
negative regulation of protein metabolic processGO:00512482820.041
ribonucleotide catabolic processGO:00092612080.041
regulation of microtubule depolymerizationGO:0031114130.040
regulation of protein localizationGO:00328802310.040
ras protein signal transductionGO:0007265770.040
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079160.039
dna catabolic process endonucleolyticGO:0000737150.039
regulation of dna replicationGO:0006275170.039
negative regulation of cell divisionGO:0051782240.039
positive regulation of purine nucleotide catabolic processGO:0033123880.039
proteasomal protein catabolic processGO:0010498980.039
muscle cell differentiationGO:00426922610.038
negative regulation of phosphate metabolic processGO:00459361840.038
organelle localizationGO:00516401790.038
purine ribonucleoside catabolic processGO:00461302050.038
purine ribonucleoside triphosphate metabolic processGO:00092052200.038
dna catabolic processGO:0006308190.037
homeostasis of number of cellsGO:00488722100.037
digestive tract morphogenesisGO:00485461470.037
response to oxygen levelsGO:0070482620.036
cell fate commitmentGO:00451652100.036
regulation of double strand break repair via homologous recombinationGO:001056920.035
positive regulation of transferase activityGO:00513471670.035
cellular response to inorganic substanceGO:0071241370.035
regulation of cellular amino acid metabolic processGO:000652150.035
dna dependent dna replicationGO:0006261240.035
regulation of hydrolase activityGO:00513362460.034
dna ligationGO:000626630.034
regulation of cellular response to stressGO:00801351590.033
histone phosphorylationGO:001657290.033
positive regulation of protein kinase activityGO:00458601440.032
response to uvGO:0009411440.032
cellular response to lipidGO:00713961450.032
single fertilizationGO:0007338820.032
negative regulation of cellular protein catabolic processGO:1903363220.031
regulation of bindingGO:00510981110.031
apoptotic signaling pathwayGO:00971903060.031
positive regulation of kinase activityGO:00336741550.031
response to inorganic substanceGO:0010035960.030
purine containing compound catabolic processGO:00725232130.030
regulation of chromatin bindingGO:003556170.030
positive regulation of cell cycle processGO:0090068610.030
Human
positive regulation of gtpase activityGO:0043547850.030
response to oxidative stressGO:00069791230.030
mitotic centrosome separationGO:000710040.029
modification dependent protein catabolic processGO:00199411330.029
cell cycle g2 m phase transitionGO:0044839200.029
regulation of purine nucleotide catabolic processGO:00331211220.029
regulation of cellular protein catabolic processGO:1903362610.029
chromosome condensationGO:0030261100.028
cellular response to acid chemicalGO:0071229680.028
rna interferenceGO:001624620.028
modification dependent macromolecule catabolic processGO:00436321330.028
regulation of protein depolymerizationGO:1901879260.028
macromolecule methylationGO:00434141200.028
spindle assembly involved in female meiosis iGO:000705720.028
rho protein signal transductionGO:0007266320.027
negative regulation of intracellular signal transductionGO:19025321670.027
female gamete generationGO:0007292740.027
meiotic dna double strand break formationGO:004213830.027
mesodermal cell migrationGO:000807840.027
negative regulation of protein depolymerizationGO:1901880210.027
cell maturationGO:00484691270.026
small gtpase mediated signal transductionGO:0007264970.026
female meiosis iGO:000714470.026
positive regulation of cell divisionGO:0051781310.026
negative regulation of protein modification processGO:00314001630.026
negative regulation of molecular functionGO:00440922580.026
response to decreased oxygen levelsGO:0036293590.026
metaphase plate congressionGO:005131020.026
regulation of dna dependent dna replicationGO:009032980.025
neural tube closureGO:0001843900.025
cell cycle g1 s phase transitionGO:0044843570.025
regulation of mitotic sister chromatid segregationGO:0033047120.025
establishment or maintenance of cell polarityGO:0007163860.025
response to organic cyclic compoundGO:00140701980.025
regulation of dna recombinationGO:0000018340.025
male meiosis iGO:0007141160.024
regulation of histone modificationGO:0031056560.024
spermatogenesisGO:00072832840.024
Fly
multi multicellular organism processGO:00447061090.024
endocytosisGO:00068971680.024
regulation of rho gtpase activityGO:0032319580.024
ribonucleoside metabolic processGO:00091192450.024
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.024
mitotic spindle assembly checkpointGO:000709470.024
nucleotide catabolic processGO:00091662170.024
histone acetylationGO:0016573410.023
positive regulation of cellular amine metabolic processGO:003324050.023
response to organonitrogen compoundGO:00102432460.023
protein import into nucleusGO:0006606950.023
atp catabolic processGO:0006200550.023
mitotic recombinationGO:000631230.022
spindle checkpointGO:0031577120.022
protein localization to organelleGO:00333651850.022
germ cell developmentGO:00072811850.022
Fly
neural tube formationGO:00018411080.022
cellular response to hormone stimulusGO:00328701500.022
regulation of cell projection organizationGO:00313442060.022
positive regulation of cellular amino acid metabolic processGO:004576430.021
protein maturationGO:00516041760.021
mitotic g2 dna damage checkpointGO:000709580.021
organism emergence from protective structureGO:007168440.021
negative regulation of protein complex disassemblyGO:0043242220.020
purine nucleoside monophosphate metabolic processGO:0009126810.020
negative regulation of sister chromatid segregationGO:003304670.020
purine ribonucleoside monophosphate metabolic processGO:0009167800.020
gtp metabolic processGO:00460391440.019
negative regulation of mitosisGO:0045839100.019
regulation of response to dna damage stimulusGO:2001020340.019
microtubule depolymerizationGO:0007019150.019
response to hypoxiaGO:0001666580.019
neural precursor cell proliferationGO:00613511210.019
reciprocal meiotic recombinationGO:0007131160.018
negative regulation of phosphorylationGO:00423261660.018
meiotic spindle organizationGO:000021290.018
protein modification by small protein conjugation or removalGO:00706472070.018
regulation of protein processingGO:0070613960.018
regulation of microtubule polymerization or depolymerizationGO:0031110200.018
protein importGO:00170381010.018
digestive system developmentGO:00551232000.018
negative regulation of wnt signaling pathwayGO:0030178730.018
positive regulation of cell cycle phase transitionGO:1901989170.018
positive regulation of cytoskeleton organizationGO:0051495490.018
Human
cellularizationGO:000734910.018
regulation of gtp catabolic processGO:00331241130.018
regulation of lymphocyte activationGO:00512492400.018
mitotic cell cycle embryonicGO:004544850.018
Fly
regulation of chromatin modificationGO:1903308570.018
wnt signaling pathwayGO:00160551880.017
microtubule polymerization or depolymerizationGO:0031109260.017
inner cell mass cell proliferationGO:0001833150.017
kinetochore organizationGO:005138320.017
negative regulation of phosphorus metabolic processGO:00105631840.017
nucleoside monophosphate metabolic processGO:0009123850.017
protein oligomerizationGO:0051259670.017
mitotic cell cycle checkpointGO:0007093310.017
positive regulation of nervous system developmentGO:00519622210.017
actin cytoskeleton organizationGO:00300362200.017
single organism nuclear importGO:1902593950.017
regulation of mitotic sister chromatid separationGO:0010965120.017
heterocycle catabolic processGO:00467002800.017
guanosine containing compound metabolic processGO:19010681440.016
regulation of apoptotic signaling pathwayGO:20012331970.016
regulation of intracellular protein transportGO:0033157820.016
maintenance of location in cellGO:0051651240.016
positive regulation of intracellular transportGO:0032388700.016
macromolecular complex disassemblyGO:0032984430.016
regulation of response to woundingGO:19030341890.016
peptidyl lysine modificationGO:0018205770.016
cellular response to decreased oxygen levelsGO:0036294180.016
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.016
regulation of neuron projection developmentGO:00109751690.016
axonogenesisGO:00074092740.016
regulation of ras gtpase activityGO:0032318880.015
neuron migrationGO:00017641220.015
posttranscriptional regulation of gene expressionGO:00106081550.015
Fly
muscle tissue developmentGO:00605373080.015
regulation of cellular component sizeGO:00325351210.015
negative regulation of mitotic sister chromatid segregationGO:003304870.015
oocyte differentiationGO:0009994350.015
ribonucleoside monophosphate metabolic processGO:0009161800.015
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.015
cell type specific apoptotic processGO:00972852680.015
g1 s transition of mitotic cell cycleGO:0000082570.015
meiosis iiGO:000713570.015
dendrite developmentGO:00163581150.015
dna biosynthetic processGO:0071897220.015
negative regulation of proteolysis involved in cellular protein catabolic processGO:1903051220.015
cohesin localization to chromatinGO:007192110.015
leukocyte apoptotic processGO:0071887710.015
gene silencing by rnaGO:0031047190.014
negative regulation of chromosome organizationGO:2001251300.014
negative regulation of protein catabolic processGO:0042177360.014
positive regulation of meiotic cell cycleGO:0051446150.014
organophosphate biosynthetic processGO:00904071220.014
protein secretionGO:00093061110.014
response to metal ionGO:0010038470.014
engulfment of apoptotic cellGO:004365230.014
regulation of wnt signaling pathwayGO:00301111230.014
cytokinetic processGO:003250620.014
negative regulation of protein maturationGO:1903318790.014
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.014
striated muscle cell developmentGO:00550021250.013
protein modification by small protein conjugationGO:00324461870.013
regulation of chromatin organizationGO:1902275570.013
positive regulation of chromatin modificationGO:1903310280.013
regulation of actin filament based processGO:0032970990.013
leukocyte proliferationGO:00706611720.013
regulation of cytokinesisGO:003246550.013
mesoderm morphogenesisGO:0048332640.013
regulation of cell cycle g2 m phase transitionGO:1902749100.013
body morphogenesisGO:0010171450.013
blastocyst developmentGO:0001824800.013
regulation of rho protein signal transductionGO:0035023710.013
endomembrane system organizationGO:00102561470.013
guanosine containing compound catabolic processGO:19010691440.013
regulation of neuron differentiationGO:00456642810.013
actomyosin structure organizationGO:0031032560.013
wound healingGO:00420601570.012
regulation of circadian rhythmGO:0042752580.012
regulation of cell activationGO:00508652890.012
organic hydroxy compound metabolic processGO:19016152030.012
response to inactivityGO:001485440.012
purine ribonucleoside monophosphate catabolic processGO:0009169570.012
positive regulation of cell deathGO:00109422240.012
posttranscriptional gene silencingGO:0016441100.012
meiotic cell cycle checkpointGO:003331320.012
regulation of metaphase anaphase transition of cell cycleGO:190209990.012
dna modificationGO:0006304500.012
atp metabolic processGO:0046034750.012
nuclear importGO:0051170950.012
asymmetric neuroblast divisionGO:005505910.012
regulation of systemic arterial blood pressure by vasopressinGO:000199230.012
regulation of protein localization to nucleusGO:1900180600.012
positive regulation of cell developmentGO:00107202370.012
intracellular protein transportGO:00068862040.012
gtp catabolic processGO:00061841430.012
internal protein amino acid acetylationGO:0006475420.012
dephosphorylationGO:00163111290.012
membrane organizationGO:00610242450.012
establishment of protein localization to organelleGO:00725941180.011
cellular lipid metabolic processGO:00442553230.011
protein acylationGO:0043543640.011
protein homooligomerizationGO:0051260430.011
negative regulation of mitotic metaphase anaphase transitionGO:004584170.011
positive regulation of protein localization to nucleusGO:1900182300.011
protein ubiquitinationGO:00165671710.011
response to ionizing radiationGO:0010212420.011
regulation of embryonic developmentGO:0045995710.011
regulation of mitotic spindle organizationGO:006023620.011
regulation of system processGO:00440572000.011
spermatid differentiationGO:00485151150.011
Fly
regulation of rac protein signal transductionGO:0035020190.011
regulation of histone acetylationGO:0035065190.011
anatomical structure homeostasisGO:00602491450.011
nucleoside monophosphate catabolic processGO:0009125590.011
regulation of lipid metabolic processGO:00192161180.011
negative regulation of cytoskeleton organizationGO:0051494360.011
microtubule slidingGO:005101210.011
positive regulation of nfat protein import into nucleusGO:005153310.011
embryonic epithelial tube formationGO:00018381300.011
ossificationGO:00015032160.011
mapk cascadeGO:00001652810.010
blood vessel morphogenesisGO:00485142850.010
gastrulationGO:00073691160.010
cellular response to oxygen levelsGO:0071453200.010
positive regulation of protein serine threonine kinase activityGO:00719021060.010
positive regulation of programmed cell deathGO:00430682180.010
response to alkaloidGO:0043279340.010
muscle cell developmentGO:00550011330.010
peptidyl serine modificationGO:0018209830.010
positive regulation of protein phosphorylationGO:00019342420.010
protein localization to chromosome centromeric regionGO:007145910.010
t cell differentiationGO:00302171740.010
regulation of ras protein signal transductionGO:00465781140.010
dna integrity checkpointGO:0031570280.010

Plk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
physical disorderDOID:008001500.012
disease of cellular proliferationDOID:1456600.012