Mus musculus

146 known processes

Nlrp3

NLR family, pyrin domain containing 3

(Aliases: MWS,AGTAVPRL,MGC129375,Cias1,FCU,FCAS,Mmig1,NALP3,AII/AVP,Pypaf1)

Nlrp3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
defense response to other organismGO:00985421970.987
regulation of cell activationGO:00508652890.970
negative regulation of cell activationGO:00508661110.950
cytokine productionGO:00018163190.948
t cell activationGO:00421102890.946
regulation of defense responseGO:00313472330.914
antibacterial peptide productionGO:000277820.881
Mouse
negative regulation of immune system processGO:00026832090.879
Mouse
interleukin 6 productionGO:0032635580.870
Mouse
extrinsic apoptotic signaling pathwayGO:00971911260.865
regulation of chemokine secretionGO:009019640.859
regulation of interleukin 6 productionGO:0032675550.851
Mouse
regulation of response to woundingGO:19030341890.835
positive regulation of immune effector processGO:00026991070.833
Mouse
cytokine secretionGO:0050663720.832
myeloid leukocyte activationGO:0002274830.798
negative regulation of inflammatory response to antigenic stimulusGO:0002862100.794
Mouse
defense response to bacteriumGO:00427421190.789
Mouse
interleukin 10 secretionGO:007260840.787
inflammatory responseGO:00069542440.785
regulation of cellular amine metabolic processGO:0033238200.782
positive regulation of defense responseGO:00313491240.775
Mouse
cellular response to cytokine stimulusGO:00713451890.753
Mouse
regulation of chemokine productionGO:0032642300.753
regulation of inflammatory responseGO:00507271470.748
positive regulation of innate immune responseGO:0045089800.731
Mouse
cellular response to peptidoglycanGO:007122440.723
Mouse
regulation of t cell proliferationGO:0042129920.717
t cell proliferationGO:00420981200.702
negative regulation of necroptotic processGO:006054690.700
regulation of t cell activationGO:00508631700.679
leukocyte activation involved in immune responseGO:00023661260.668
response to peptidoglycanGO:003249490.656
Mouse
i kappab kinase nf kappab signalingGO:0007249850.655
Human Mouse
regulation of lymphocyte activationGO:00512492400.647
response to molecule of bacterial originGO:00022371430.638
Human Mouse
antimicrobial peptide productionGO:000277520.631
Mouse
positive regulation of cytokine productionGO:00018191740.617
regulation of interferon gamma productionGO:0032649570.611
Mouse
negative regulation of inflammatory responseGO:0050728610.608
Human Mouse
leukocyte differentiationGO:00025213420.574
adaptive immune responseGO:00022501550.571
Mouse
regulation of lymphocyte differentiationGO:00456191070.565
negative regulation of necrotic cell deathGO:0060547110.564
positive regulation of apoptotic signaling pathwayGO:2001235950.553
leukocyte mediated immunityGO:00024431740.549
Mouse
interleukin 8 productionGO:003263740.542
negative regulation of adaptive immune responseGO:0002820250.532
Mouse
negative regulation of cytokine productionGO:0001818840.531
Human Mouse
regulation of defense response to bacteriumGO:190042430.526
Mouse
activation of innate immune responseGO:0002218560.516
Mouse
negative regulation of cellular protein metabolic processGO:00322692470.511
protein secretionGO:00093061110.508
negative regulation of lymphocyte activationGO:0051250910.506
production of molecular mediator of immune responseGO:00024401030.505
Mouse
cytokine mediated signaling pathwayGO:00192211150.500
regulation of transferase activityGO:00513382630.488
Mouse
positive regulation of lymphocyte proliferationGO:0050671700.472
defense response to gram negative bacteriumGO:0050829280.470
myeloid dendritic cell activationGO:0001773250.462
cellular response to biotic stimulusGO:0071216920.457
Human Mouse
cell activation involved in immune responseGO:00022631260.457
negative regulation of protein metabolic processGO:00512482820.446
pattern recognition receptor signaling pathwayGO:0002221470.440
Mouse
necroptotic processGO:0070266210.435
regulation of lymphocyte apoptotic processGO:0070228410.428
regulation of t cell differentiationGO:0045580830.420
interleukin 18 mediated signaling pathwayGO:003565520.414
cellular response to lipopolysaccharideGO:0071222770.412
Human
regulation of cytokine productionGO:00018172660.412
positive regulation of t cell proliferationGO:0042102520.410
positive regulation of antibacterial peptide biosynthetic processGO:000696310.403
Mouse
cellular amine metabolic processGO:0044106440.399
toll like receptor signaling pathwayGO:0002224380.394
Mouse
regulation of secretion by cellGO:19035302490.391
negative regulation of b cell activationGO:0050869270.385
positive regulation of chemokine secretionGO:009019740.382
positive regulation of interferon gamma productionGO:0032729390.381
interleukin 1 productionGO:0032612310.378
regulation of tumor necrosis factor productionGO:0032680490.376
Mouse
regulation of toll like receptor signaling pathwayGO:0034121200.374
Mouse
neutrophil mediated killing of gram negative bacteriumGO:007094540.372
regulation of proteolysisGO:00301621640.367
protein processingGO:00164851630.360
negative regulation of molecular functionGO:00440922580.359
Human Mouse
t helper cell differentiationGO:0042093280.356
positive regulation of interleukin 6 productionGO:0032755370.351
Mouse
regulation of cell migrationGO:00303342190.350
Mouse
activation of mapk activity involved in innate immune responseGO:003541920.349
Mouse
toll like receptor 9 signaling pathwayGO:003416260.345
regulation of necroptotic processGO:0060544100.341
positive regulation of interleukin 8 productionGO:003275720.328
response to lipopolysaccharideGO:00324961280.326
Human Mouse
response to radiationGO:00093141650.320
regulation of peptidyl tyrosine phosphorylationGO:0050730930.318
Mouse
positive regulation of membrane protein ectodomain proteolysisGO:005104430.316
macromolecule catabolic processGO:00090572810.315
toll like receptor 7 signaling pathwayGO:003415440.306
cellular response to dna damage stimulusGO:00069742070.304
lymphocyte activation involved in immune responseGO:0002285930.301
regulation of innate immune responseGO:0045088910.300
Mouse
inflammatory response to woundingGO:009059440.293
antibacterial peptide biosynthetic processGO:000278020.287
Mouse
negative regulation of interleukin 6 productionGO:0032715170.286
regulation of antimicrobial humoral responseGO:000275930.284
Mouse
regulation of protein kinase activityGO:00458592320.279
Mouse
interleukin 2 biosynthetic processGO:0042094150.276
regulation of cysteine type endopeptidase activityGO:2000116650.272
positive regulation of production of molecular mediator of immune responseGO:0002702450.272
Mouse
regulation of interleukin 10 secretionGO:200117940.268
regulation of cell motilityGO:20001452360.267
Mouse
leukocyte migrationGO:00509001240.265
Mouse
interleukin 6 biosynthetic processGO:0042226120.256
positive regulation of protein secretionGO:0050714520.254
positive regulation of apoptotic processGO:00430652170.253
protein maturationGO:00516041760.252
regulation of secretionGO:00510462740.250
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.249
positive regulation of interleukin 1 secretionGO:0050716140.248
chemotaxisGO:00069352470.245
Mouse
negative regulation of interferon gamma productionGO:0032689180.245
Mouse
interleukin 11 mediated signaling pathwayGO:003815420.242
regulation of protein secretionGO:0050708820.241
intrinsic apoptotic signaling pathwayGO:00971931320.238
cellular response to lipidGO:00713961450.235
Human
t cell differentiationGO:00302171740.234
detection of molecule of bacterial originGO:003249020.230
reactive oxygen species metabolic processGO:0072593840.228
t cell apoptotic processGO:0070231390.228
programmed necrotic cell deathGO:0097300280.227
glial cell apoptotic processGO:003434930.227
chemokine secretionGO:009019550.226
positive regulation of stress activated mapk cascadeGO:0032874480.225
Mouse
regulation of protein localizationGO:00328802310.220
antimicrobial peptide biosynthetic processGO:000277720.219
Mouse
cell divisionGO:00513011200.215
regulation of lymphocyte proliferationGO:00506701170.213
negative regulation of t cell activationGO:0050868650.212
antibacterial humoral responseGO:001973180.212
Mouse
somatic diversification of immune receptorsGO:0002200530.211
myeloid cell differentiationGO:00300992330.206
positive regulation of interleukin 8 secretionGO:200048410.205
negative regulation of transferase activityGO:0051348850.200
response to interleukin 1GO:0070555110.200
regulation of peptidase activityGO:0052547960.199
positive regulation of proteolysisGO:0045862850.196
regulation of intrinsic apoptotic signaling pathwayGO:2001242610.195
negative regulation of phosphorus metabolic processGO:00105631840.190
Mouse
b cell activationGO:00421131610.190
amine metabolic processGO:0009308450.182
regulation of cell cycleGO:00517262810.182
negative regulation of leukocyte proliferationGO:0070664460.182
negative regulation of lymphocyte proliferationGO:0050672450.181
regulation of kinase activityGO:00435492490.180
Mouse
regulation of cellular ketone metabolic processGO:0010565660.176
regulation of cellular catabolic processGO:00313292420.175
Mouse
interspecies interaction between organismsGO:0044419830.170
Mouse
detection of fungusGO:001604620.169
positive regulation of protein transportGO:0051222930.164
negative regulation of chemokine productionGO:003268240.161
angiogenesisGO:00015252010.161
protein modification by small protein conjugation or removalGO:00706472070.159
Mouse
cellular response to molecule of bacterial originGO:0071219830.159
Human Mouse
regulation of antibacterial peptide biosynthetic processGO:000280810.158
Mouse
positive regulation of antimicrobial peptide productionGO:000222510.156
Mouse
negative regulation of cell proliferationGO:00082852960.156
negative regulation of kinase activityGO:0033673810.155
regulation of protein processingGO:0070613960.152
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.151
regulation of cellular amino acid metabolic processGO:000652150.150
positive regulation of t cell activationGO:00508701010.150
interferon gamma productionGO:0032609670.148
Mouse
positive regulation of toll like receptor 9 signaling pathwayGO:003416520.148
regulation of interleukin 8 productionGO:003267730.147
chromatin organizationGO:00063252060.146
organonitrogen compound biosynthetic processGO:19015661920.146
Mouse
defense response to virusGO:0051607680.146
positive regulation of peptidase activityGO:0010952490.145
interleukin 18 productionGO:003262140.145
g protein coupled receptor signaling pathwayGO:00071862430.144
regulation of necrotic cell deathGO:0010939130.143
activation of immune responseGO:00022531380.143
Mouse
homeostasis of number of cellsGO:00488722100.142
interleukin 27 mediated signaling pathwayGO:007010610.140
tyrosine phosphorylation of stat1 proteinGO:004250830.139
regulation of protein transportGO:00512231630.139
negative regulation of t cell proliferationGO:0042130380.139
purine containing compound metabolic processGO:00725213110.137
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.137
Mouse
leukocyte proliferationGO:00706611720.136
regulation of activated t cell proliferationGO:0046006160.136
positive regulation of defense response to bacteriumGO:190042610.135
Mouse
chemokine metabolic processGO:0050755100.135
positive regulation of cell deathGO:00109422240.134
negative regulation of protein modification processGO:00314001630.133
regulation of establishment of protein localizationGO:00702011810.133
nucleotide metabolic processGO:00091173320.132
organic hydroxy compound metabolic processGO:19016152030.132
positive regulation of mapk cascadeGO:00434101700.130
Mouse
positive regulation of cellular amino acid metabolic processGO:004576430.130
nuclear divisionGO:00002801580.130
lymphocyte differentiationGO:00300982420.129
somatic recombination of immunoglobulin genes involved in immune responseGO:0002204360.129
cell surface pattern recognition receptor signaling pathwayGO:000275220.128
regulation of cellular response to stressGO:00801351590.127
Mouse
necrotic cell deathGO:0070265300.126
regulation of intracellular transportGO:00323861590.125
Human
positive regulation of erk1 and erk2 cascadeGO:0070374470.125
Mouse
regulation of adaptive immune responseGO:0002819900.124
Mouse
regulation of leukocyte mediated immunityGO:00027031040.123
Mouse
positive regulation of t cell differentiationGO:0045582520.123
wound healing involved in inflammatory responseGO:000224640.123
tumor necrosis factor superfamily cytokine productionGO:0071706510.122
Mouse
dna metabolic processGO:00062593030.122
phagocytosisGO:0006909660.122
Mouse
t cell activation involved in immune responseGO:0002286430.121
regulation of response to biotic stimulusGO:0002831380.120
Mouse
negative regulation of phosphate metabolic processGO:00459361840.120
Mouse
response to oxidative stressGO:00069791230.120
cellular response to interleukin 18GO:007135130.119
positive regulation of chemotaxisGO:0050921380.118
tyrosine phosphorylation of stat proteinGO:0007260230.115
immune effector processGO:00022523210.115
negative regulation of defense responseGO:0031348770.114
Human Mouse
regulation of thymocyte apoptotic processGO:0070243140.114
response to tumor necrosis factorGO:0034612260.114
negative regulation of phosphorylationGO:00423261660.113
Mouse
lymphocyte proliferationGO:00466511640.113
compound eye developmentGO:004874910.112
regulation of apoptotic signaling pathwayGO:20012331970.112
response to atpGO:003319880.111
rho protein signal transductionGO:0007266320.110
negative regulation of apoptotic signaling pathwayGO:20012341040.110
jak stat cascadeGO:0007259420.109
cytoplasmic pattern recognition receptor signaling pathwayGO:0002753100.109
Mouse
serotonin secretion by mast cellGO:000255210.109
interleukin 33 mediated signaling pathwayGO:003817210.108
myeloid leukocyte mediated immunityGO:0002444420.107
myeloid dendritic cell differentiationGO:0043011160.107
regulation of leukocyte proliferationGO:00706631210.107
regulation of protein maturationGO:1903317960.106
lymphocyte apoptotic processGO:0070227540.106
regulation of erk1 and erk2 cascadeGO:0070372710.106
Mouse
positive regulation of phagocytosisGO:0050766260.105
Mouse
somatic recombination of immunoglobulin gene segmentsGO:0016447420.105
regulation of protein serine threonine kinase activityGO:00719001570.105
Mouse
positive regulation of response to woundingGO:1903036660.105
negative regulation of protein processingGO:0010955790.104
regulation of adiponectin secretionGO:007016320.104
regulation of response to cytokine stimulusGO:0060759230.103
cellular macromolecule catabolic processGO:00442652060.103
cell fate commitmentGO:00451652100.102
regulation of endopeptidase activityGO:0052548890.102
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.102
mapk cascadeGO:00001652810.101
Mouse
regulation of inflammatory response to antigenic stimulusGO:0002861210.101
Mouse
nucleobase containing small molecule metabolic processGO:00550863520.100
heterocycle catabolic processGO:00467002800.099
regulation of hydrolase activityGO:00513362460.099
positive regulation of programmed cell deathGO:00430682180.098
regulation of toll like receptor 2 signaling pathwayGO:003413530.098
Mouse
nitrogen compound transportGO:00717052710.097
Human
regulation of autophagyGO:0010506300.097
Mouse
positive regulation of interleukin 18 productionGO:003274120.097
regulation of leukocyte differentiationGO:19021051590.095
sensory perceptionGO:00076002450.094
necroptotic signaling pathwayGO:009752730.094
regulation of antibacterial peptide productionGO:000278610.091
Mouse
defense response to gram positive bacteriumGO:0050830500.091
Mouse
t cell differentiation involved in immune responseGO:0002292300.091
positive regulation of interleukin 1 alpha secretionGO:005071730.090
positive regulation of macrophage activationGO:0043032100.090
negative regulation of hydrolase activityGO:0051346710.089
negative regulation of intracellular signal transductionGO:19025321670.089
Human Mouse
purine nucleoside triphosphate metabolic processGO:00091442260.089
regulation of tyrosine phosphorylation of stat proteinGO:0042509200.088
lipopolysaccharide mediated signaling pathwayGO:0031663250.087
positive regulation of leukocyte proliferationGO:0070665730.087
negative regulation of cell cycleGO:00457861230.087
myeloid leukocyte differentiationGO:00025731190.087
regulation of protein targetingGO:1903533610.087
Human
regulation of interleukin 1 secretionGO:0050704150.086
negative regulation of serotonin secretionGO:001406320.086
response to organonitrogen compoundGO:00102432460.086
Mouse
apoptotic signaling pathwayGO:00971903060.086
positive regulation of chemokine productionGO:0032722220.085
positive regulation of cysteine type endopeptidase activityGO:2001056390.085
regulation of interleukin 1 alpha productionGO:003265040.084
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.083
response to dsrnaGO:0043331300.083
Mouse
response to growth factorGO:00708481980.083
response to light stimulusGO:00094161350.083
lung developmentGO:00303241640.081
regulation of cellular component biogenesisGO:00440871810.080
positive regulation of protein modification processGO:00314012990.080
Mouse
tumor necrosis factor productionGO:0032640500.080
Mouse
regulation of interleukin 1 beta productionGO:0032651250.080
ribonucleotide metabolic processGO:00092592910.080
cellular response to tumor necrosis factorGO:0071356210.080
tumor necrosis factor mediated signaling pathwayGO:0033209130.080
peptide transportGO:00158331330.079
Human
chemokine productionGO:0032602340.079
Mouse
leukocyte homeostasisGO:0001776790.078
regulation of execution phase of apoptosisGO:190011790.078
epidermis developmentGO:00085441870.078
negative regulation of leukocyte differentiationGO:1902106510.078
neuron deathGO:00709971540.077
negative regulation of activated t cell proliferationGO:004600770.077
ripoptosome assembly involved in necroptotic processGO:190102660.077
positive regulation of extrinsic apoptotic signaling pathwayGO:2001238340.077
cd4 positive alpha beta t cell cytokine productionGO:003574340.076
regulation of stress activated mapk cascadeGO:0032872690.076
Mouse
regulation of membrane potentialGO:00423911920.076
negative regulation of map kinase activityGO:0043407340.076
ribose phosphate metabolic processGO:00196932910.075
modulation of growth of symbiont involved in interaction with hostGO:0044144190.075
Mouse
interferon beta biosynthetic processGO:004535040.075
symbiosis encompassing mutualism through parasitismGO:0044403830.075
Mouse
negative regulation of secretionGO:0051048610.075
Human
t cell migrationGO:0072678190.075
alpha beta t cell proliferationGO:0046633210.075
protein heterooligomerizationGO:0051291140.075
cellularizationGO:000734910.074
divalent inorganic cation homeostasisGO:00725071380.074
positive regulation of map kinase activityGO:0043406840.074
Mouse
negative regulation of protein serine threonine kinase activityGO:0071901490.074
negative regulation of endopeptidase activityGO:0010951440.074
regulation of jak stat cascadeGO:0046425340.074
keratinocyte differentiationGO:0030216480.073
negative regulation of chronic inflammatory responseGO:000267730.073
immunoglobulin mediated immune responseGO:0016064690.073
Mouse
positive regulation of protein phosphorylationGO:00019342420.073
Mouse
response to oxygen levelsGO:0070482620.073
antibacterial peptide secretionGO:000277910.073
keratinocyte migrationGO:005154630.073
positive regulation of lymphocyte activationGO:00512511400.073
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.072
negative regulation of mast cell degranulationGO:004330540.072
nucleoside phosphate metabolic processGO:00067533380.071
regulation of neuron apoptotic processGO:00435231220.071
positive regulation of organelle organizationGO:00106381280.071
regulation of chronic inflammatory response to antigenic stimulusGO:000287430.071
small gtpase mediated signal transductionGO:0007264970.070
single organism cell adhesionGO:00986021560.070
nucleic acid phosphodiester bond hydrolysisGO:0090305490.070
regulation of acute inflammatory responseGO:0002673270.069
Human
interleukin 2 productionGO:0032623330.069
Mouse
regulation of mapk cascadeGO:00434082480.069
Mouse
negative regulation of interleukin 5 productionGO:003271440.069
neutrophil chemotaxisGO:0030593360.068
Mouse
positive regulation by symbiont of defense related host nitric oxide productionGO:005234710.068
response to drugGO:0042493750.068
aromatic compound catabolic processGO:00194392860.068
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.068
negative regulation of cellular component organizationGO:00511291940.067
embryonic epithelial tube formationGO:00018381300.067
organelle fissionGO:00482851700.067
regulation of interleukin 1 productionGO:0032652260.067
b cell homeostasisGO:0001782340.066
regulation of hormone levelsGO:00108172110.066
dna catabolic process endonucleolyticGO:0000737150.066
protein catabolic processGO:00301632210.066
innate immune response activating cell surface receptor signaling pathwayGO:000222040.066
signal transduction in absence of ligandGO:0038034550.065
interleukin 1 beta productionGO:0032611300.064
regulation of interleukin 1 alpha secretionGO:005070530.064
regulation of immunoglobulin mediated immune responseGO:0002889370.064
Mouse
regulation of action potentialGO:009890040.064
isotype switchingGO:0045190360.063
regulation of cytokine production involved in immune responseGO:0002718260.063
b cell activation involved in immune responseGO:0002312500.063
epithelial tube morphogenesisGO:00605623030.062
positive regulation of lymphocyte differentiationGO:0045621610.061
nuclear transportGO:00511691390.061
Human
negative regulation of chemokine biosynthetic processGO:004507920.061
pyroptosisGO:007026980.060
response to host defensesGO:005220030.060
immune response regulating cell surface receptor signaling pathwayGO:0002768800.060
regulation of map kinase activityGO:00434051200.059
Mouse
positive regulation of cellular amine metabolic processGO:003324050.059
negative regulation of protein phosphorylationGO:00019331260.059
somatic diversification of immunoglobulins involved in immune responseGO:0002208360.059
regulation of t helper 1 type immune responseGO:0002825170.059
Mouse
negative regulation of phagocytosisGO:005076540.058
positive regulation of interleukin 1 alpha productionGO:003273040.058
positive regulation of activation of membrane attack complexGO:000197020.058
hormone secretionGO:00468791280.058
carbohydrate derivative catabolic processGO:19011362310.057
regulation of mast cell activationGO:0033003210.057
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.057
positive regulation of kinase activityGO:00336741550.057
Mouse
ectopic germ cell programmed cell deathGO:003523490.056
hindbrain developmentGO:00309021280.056
regulation of immunoglobulin productionGO:0002637420.056
natural killer cell activationGO:0030101440.056
positive regulation of interleukin 1 beta productionGO:0032731160.056
release of cytochrome c from mitochondriaGO:0001836230.056
intrinsic apoptotic signaling pathway by p53 class mediatorGO:0072332350.055
interleukin 1 alpha secretionGO:005070330.055
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.055
Mouse
dna recombinationGO:0006310920.055
positive regulation of leukocyte mediated immunityGO:0002705700.055
Mouse
positive regulation of nf kappab transcription factor activityGO:0051092300.055
Human Mouse
cellular amino acid metabolic processGO:00065201030.055
myd88 dependent toll like receptor signaling pathwayGO:000275570.055
positive regulation of leukocyte differentiationGO:1902107860.054
histone modificationGO:00165701590.054
chemokine biosynthetic processGO:004203380.054
muscle cell developmentGO:00550011330.054
positive regulation of cell migrationGO:00303351090.054
engulfment of apoptotic cellGO:004365230.054
blood vessel morphogenesisGO:00485142850.054
purine ribonucleoside triphosphate metabolic processGO:00092052200.053
regulation of interleukin 8 secretionGO:200048220.053
respiratory tube developmentGO:00303231670.053
organonitrogen compound catabolic processGO:19015652640.053
response to organic cyclic compoundGO:00140701980.053
Mouse
positive regulation of antimicrobial peptide biosynthetic processGO:000280710.053
Mouse
spermatid developmentGO:00072861080.052
cellular homeostasisGO:00197252400.051
negative regulation of response to woundingGO:1903035770.051
Human Mouse
regulation of cd4 positive alpha beta t cell activationGO:2000514240.051
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathwayGO:200126930.051
killing of cells in other organism involved in symbiotic interactionGO:0051883130.050
negative regulation of myeloid dendritic cell activationGO:003088630.050
nucleocytoplasmic transportGO:00069131390.050
Human
negative regulation of growth of symbiont involved in interaction with hostGO:0044146190.050
Mouse
regulation of ion transportGO:00432692150.049
regulation of lymphocyte migrationGO:2000401140.049
single organismal cell cell adhesionGO:00163371310.049
immunoglobulin transcytosis in epithelial cellsGO:000241420.048
regulation of nucleocytoplasmic transportGO:0046822730.048
Human
phosphatidylinositol mediated signalingGO:0048015410.048
somatic diversification of immunoglobulinsGO:0016445430.048
mitochondrion organizationGO:00070051340.048
lymphocyte migrationGO:0072676260.048
adiponectin secretionGO:007016220.048
muscle cell differentiationGO:00426922610.048
endocytosisGO:00068971680.047
Mouse
macromolecule methylationGO:00434141200.047
skin developmentGO:00435882200.047
cellular response to external stimulusGO:0071496880.047
regulation of membrane protein ectodomain proteolysisGO:005104330.047
cellular response to interferon betaGO:0035458210.047
positive regulation of cytoplasmic transportGO:1903651400.047
lymphocyte homeostasisGO:0002260640.047
positive regulation of transcription factor import into nucleusGO:004299380.047
positive regulation of jnk cascadeGO:0046330460.046
Mouse
regulation of acute inflammatory response to non antigenic stimulusGO:000287720.046
purinergic receptor signaling pathwayGO:003558770.046
anion transportGO:00068201770.046
cytokine production involved in immune responseGO:0002367340.046
negative regulation of macrophage apoptotic processGO:200011030.046
Mouse
transmembrane transportGO:00550854120.046
chronic inflammatory response to antigenic stimulusGO:000243930.045
negative regulation of protein maturationGO:1903318790.045
positive regulation of interleukin 6 secretionGO:200077810.045
regulation of dna recombinationGO:0000018340.045
negative regulation of cellular amine metabolic processGO:003323910.044
positive regulation of transferase activityGO:00513471670.044
Mouse
wound healingGO:00420601570.044
Mouse
positive regulation of intrinsic apoptotic signaling pathwayGO:2001244250.044
internal peptidyl lysine acetylationGO:0018393420.044
positive regulation of cell activationGO:00508671580.044
cellular calcium ion homeostasisGO:00068741190.044
positive regulation of isotype switching to igg isotypesGO:004830470.044
cd4 positive alpha beta t cell activationGO:0035710450.043
humoral immune responseGO:0006959570.043
Mouse
positive regulation of monocyte chemotaxisGO:009002620.043
regulation of muscle tissue developmentGO:1901861970.043
macrophage activationGO:0042116270.043
sperm individualizationGO:000729110.043
digestive system developmentGO:00551232000.043
regulation of peptide transportGO:0090087910.043
Human
positive regulation of reactive oxygen species biosynthetic processGO:190342820.043
neural tube developmentGO:00219151600.042
mast cell activationGO:0045576270.042
neutrophil mediated killing of symbiont cellGO:007094380.042
cellular response to transforming growth factor beta stimulusGO:0071560880.042
positive regulation of hemostasisGO:1900048100.042
detection of lipopolysaccharideGO:003249710.042
positive regulation of neutrophil mediated killing of symbiont cellGO:007096110.041
negative regulation of protein secretionGO:0050709200.041
Human
epithelial tube formationGO:00721751300.041
nucleotide binding oligomerization domain containing signaling pathwayGO:007042360.041
Mouse
tissue homeostasisGO:00018941150.041
ribonucleoside triphosphate metabolic processGO:00091992200.041
negative regulation of t cell mediated immunityGO:000271090.041
Mouse
organic cyclic compound catabolic processGO:19013612950.041
jnk cascadeGO:0007254720.041
Mouse
peptidyl serine modificationGO:0018209830.041

Nlrp3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.912
disease of cellular proliferationDOID:1456600.912
organ system cancerDOID:005068600.654
immune system diseaseDOID:291400.155
disease of anatomical entityDOID:700.155
lymphatic system diseaseDOID:7500.155
gastrointestinal system cancerDOID:311900.104
immune system cancerDOID:006008300.058