Mus musculus

16 known processes

Kdm4a

lysine (K)-specific demethylase 4A

(Aliases: Jmjd2,Jmjd2a,JHDM3A,mKIAA0677,MGC28562,D4Ertd222e)

Kdm4a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nucleosome disassemblyGO:000633710.184
protein dna complex disassemblyGO:003298610.136
chromatin disassemblyGO:003149810.124
chromatin organizationGO:00063252060.084
Human Yeast Mouse Worm Fly
regulation of cell cycleGO:00517262810.059
cellular amino acid metabolic processGO:00065201030.052
amine metabolic processGO:0009308450.051
male gamete generationGO:00482322850.050
chromatin modificationGO:00165681870.050
Human Yeast Mouse Worm Fly
negative regulation of cell proliferationGO:00082852960.050
purine ribonucleotide metabolic processGO:00091502900.049
spermatogenesisGO:00072832840.047
nucleoside phosphate metabolic processGO:00067533380.047
nucleobase containing small molecule metabolic processGO:00550863520.045
cellular amine metabolic processGO:0044106440.045
regulation of cellular ketone metabolic processGO:0010565660.043
response to organonitrogen compoundGO:00102432460.042
camera type eye developmentGO:00430102660.042
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.041
purine nucleoside metabolic processGO:00422782410.041
purine containing compound metabolic processGO:00725213110.041
regulation of cellular catabolic processGO:00313292420.041
nucleotide metabolic processGO:00091173320.040
organonitrogen compound catabolic processGO:19015652640.039
purine nucleotide metabolic processGO:00061633020.039
ribonucleoside metabolic processGO:00091192450.039
purine ribonucleoside catabolic processGO:00461302050.039
ribose phosphate metabolic processGO:00196932910.038
positive regulation of cellular amino acid metabolic processGO:004576430.038
organic cyclic compound catabolic processGO:19013612950.038
covalent chromatin modificationGO:00165691630.038
Human Yeast Mouse Worm Fly
regulation of cellular amino acid metabolic processGO:000652150.037
histone modificationGO:00165701590.037
Human Yeast Mouse Worm Fly
peptidyl amino acid modificationGO:00181933360.037
cellular lipid metabolic processGO:00442553230.037
Yeast
nucleotide catabolic processGO:00091662170.037
purine nucleoside triphosphate metabolic processGO:00091442260.036
positive regulation of cellular amine metabolic processGO:003324050.036
ribonucleotide metabolic processGO:00092592910.036
organophosphate catabolic processGO:00464342320.036
nucleoside triphosphate metabolic processGO:00091412300.036
nucleoside metabolic processGO:00091162460.035
cellular nitrogen compound catabolic processGO:00442702800.034
purine ribonucleoside metabolic processGO:00461282410.034
cellular ketone metabolic processGO:0042180840.034
carbohydrate metabolic processGO:00059752300.034
ribonucleoside catabolic processGO:00424542060.033
regionalizationGO:00030023370.032
carbohydrate derivative catabolic processGO:19011362310.032
purine ribonucleoside triphosphate metabolic processGO:00092052200.032
ras protein signal transductionGO:0007265770.032
small gtpase mediated signal transductionGO:0007264970.032
aromatic compound catabolic processGO:00194392860.032
negative regulation of protein metabolic processGO:00512482820.031
nucleoside phosphate catabolic processGO:19012922220.031
cell adhesionGO:00071553290.030
forebrain developmentGO:00309003020.030
regulation of cellular amine metabolic processGO:0033238200.030
gene silencingGO:0016458380.029
regulation of membrane potentialGO:00423911920.029
macromolecule catabolic processGO:00090572810.029
glycosyl compound catabolic processGO:19016582060.029
apoptotic signaling pathwayGO:00971903060.028
purine ribonucleoside triphosphate catabolic processGO:00092071990.028
regulation of hydrolase activityGO:00513362460.028
leukocyte differentiationGO:00025213420.027
purine nucleoside catabolic processGO:00061522050.027
muscle cell differentiationGO:00426922610.027
ion transmembrane transportGO:00342203610.027
methylationGO:00322591340.027
transmembrane transportGO:00550854120.027
epithelial tube morphogenesisGO:00605623030.027
gtp catabolic processGO:00061841430.027
dna metabolic processGO:00062593030.026
regulation of organelle organizationGO:00330432890.026
regulation of neuron differentiationGO:00456642810.026
Rat
regulation of cell cycle processGO:00105641600.026
protein maturationGO:00516041760.026
positive regulation of cellular catabolic processGO:00313311480.026
purine containing compound catabolic processGO:00725232130.026
stem cell proliferationGO:00720891170.025
cellular response to organonitrogen compoundGO:00714171450.025
carbohydrate derivative biosynthetic processGO:19011371830.025
macromolecule methylationGO:00434141200.025
glycosyl compound metabolic processGO:19016572460.025
muscle tissue developmentGO:00605373080.024
regulation of nucleotide metabolic processGO:00061401690.024
rho protein signal transductionGO:0007266320.024
membrane organizationGO:00610242450.024
negative regulation of cell developmentGO:00107211690.024
Rat
protein modification by small protein conjugation or removalGO:00706472070.024
nucleoside triphosphate catabolic processGO:00091432050.024
purine nucleoside triphosphate catabolic processGO:00091462030.024
heterocycle catabolic processGO:00467002800.024
organic hydroxy compound metabolic processGO:19016152030.023
sensory organ morphogenesisGO:00905962420.023
regulation of secretion by cellGO:19035302490.023
cellular response to hormone stimulusGO:00328701500.023
placenta developmentGO:00018901400.023
nitrogen compound transportGO:00717052710.023
regulation of hormone levelsGO:00108172110.023
protein processingGO:00164851630.023
ribonucleoside triphosphate metabolic processGO:00091992200.023
axonogenesisGO:00074092740.022
cation transmembrane transportGO:00986552660.022
negative regulation of nervous system developmentGO:00519611560.022
Rat
viral gene expressionGO:001908030.022
cell type specific apoptotic processGO:00972852680.022
posttranscriptional regulation of gene expressionGO:00106081550.022
neural tube developmentGO:00219151600.022
protein ubiquitinationGO:00165671710.022
negative regulation of cellular protein metabolic processGO:00322692470.022
response to peptide hormoneGO:00434341270.022
regulation of cellular response to stressGO:00801351590.022
protein catabolic processGO:00301632210.022
positive regulation of hydrolase activityGO:00513451480.022
protein methylationGO:0006479810.021
oocyte axis specificationGO:000730920.021
ribonucleotide catabolic processGO:00092612080.021
cellular macromolecule catabolic processGO:00442652060.021
cation transportGO:00068123990.021
skeletal system developmentGO:00015013560.021
alcohol metabolic processGO:00060661160.021
cellular homeostasisGO:00197252400.021
guanosine containing compound metabolic processGO:19010681440.021
microtubule based processGO:00070172360.020
purine nucleotide catabolic processGO:00061952110.020
regulation of secretionGO:00510462740.020
embryonic organ morphogenesisGO:00485622760.020
purine ribonucleotide catabolic processGO:00091542080.020
cellular response to dna damage stimulusGO:00069742070.020
lipid biosynthetic processGO:00086101790.020
Yeast
organonitrogen compound biosynthetic processGO:19015661920.020
response to peptideGO:19016521360.020
striated muscle tissue developmentGO:00147062930.020
immune effector processGO:00022523210.020
stem cell differentiationGO:00488632680.020
regulation of anatomical structure sizeGO:00900661780.020
synaptic transmissionGO:00072683290.019
positive regulation of apoptotic processGO:00430652170.019
cellular response to lipidGO:00713961450.019
oocyte constructionGO:000730820.019
regulation of chromatin silencingGO:003193520.019
neural precursor cell proliferationGO:00613511210.019
negative regulation of cellular component organizationGO:00511291940.019
mitotic cell cycleGO:00002781950.019
maintenance of locationGO:0051235890.019
regulation of purine nucleotide metabolic processGO:19005421690.019
ribonucleoside triphosphate catabolic processGO:00092031990.019
endocytosisGO:00068971680.019
intrinsic apoptotic signaling pathwayGO:00971931320.019
response to lipopolysaccharideGO:00324961280.019
positive regulation of nucleotide metabolic processGO:00459811140.018
regulation of cell activationGO:00508652890.018
positive regulation of protein modification processGO:00314012990.018
wnt signaling pathwayGO:00160551880.018
embryonic epithelial tube formationGO:00018381300.018
response to insulinGO:00328681000.018
cell substrate adhesionGO:00315891300.018
reactive oxygen species metabolic processGO:0072593840.018
g protein coupled receptor signaling pathwayGO:00071862430.018
epithelial tube formationGO:00721751300.018
developmental maturationGO:00217001930.018
gtp metabolic processGO:00460391440.018
protein complex disassemblyGO:0043241400.018
negative regulation of growthGO:0045926990.018
regulation of apoptotic signaling pathwayGO:20012331970.018
protein modification by small protein conjugationGO:00324461870.018
regulation of lymphocyte activationGO:00512492400.017
positive regulation of programmed cell deathGO:00430682180.017
macromolecular complex disassemblyGO:0032984430.017
nucleoside catabolic processGO:00091642060.017
heart morphogenesisGO:00030071780.017
reactive oxygen species biosynthetic processGO:190340980.017
multicellular organismal signalingGO:0035637910.017
response to acid chemicalGO:00011011110.017
positive regulation of gtpase activityGO:0043547850.017
germ cell developmentGO:00072811850.017
positive regulation of purine nucleotide metabolic processGO:19005441140.017
positive regulation of nervous system developmentGO:00519622210.017
Rat
blood circulationGO:00080151950.017
monocarboxylic acid metabolic processGO:00327871910.017
gland developmentGO:00487323300.017
regulation of cell adhesionGO:00301551540.017
glycoprotein metabolic processGO:00091001160.017
guanosine containing compound catabolic processGO:19010691440.017
regulation of purine nucleotide catabolic processGO:00331211220.017
lymphocyte differentiationGO:00300982420.017
microtubule cytoskeleton organizationGO:00002261570.017
negative regulation of cell cycleGO:00457861230.016
response to molecule of bacterial originGO:00022371430.016
positive regulation of cell developmentGO:00107202370.016
Rat
positive regulation of cell deathGO:00109422240.016
epithelial cell developmentGO:00020641590.016
small molecule biosynthetic processGO:00442831320.016
ubiquitin dependent protein catabolic processGO:00065111290.016
positive regulation of cell activationGO:00508671580.016
regulation of protein localizationGO:00328802310.016
organelle localizationGO:00516401790.016
sensory perceptionGO:00076002450.016
cytokine productionGO:00018163190.016
oxidation reduction processGO:00551143420.016
Human Yeast Worm Fly
regulation of nucleoside metabolic processGO:00091181300.016
rhythmic processGO:00485111740.016
regulation of cell migrationGO:00303342190.016
mitotic cell cycle processGO:19030471590.016
regulation of cytokine productionGO:00018172660.016
actin cytoskeleton organizationGO:00300362200.016
multicellular organismal homeostasisGO:00488711640.016
response to organic cyclic compoundGO:00140701980.016
inorganic ion transmembrane transportGO:00986602340.016
protein alkylationGO:0008213810.016
circulatory system processGO:00030131970.016
inorganic cation transmembrane transportGO:00986622070.015
neural tube formationGO:00018411080.015
proteasomal protein catabolic processGO:0010498980.015
appendage developmentGO:00487361660.015
cellular carbohydrate metabolic processGO:00442621190.015
gonad developmentGO:00084061410.015
spermatid differentiationGO:00485151150.015
retina development in camera type eyeGO:00600411190.015
regulation of cell motilityGO:20001452360.015
endomembrane system organizationGO:00102561470.015
negative regulation of molecular functionGO:00440922580.015
regulation of mitotic cell cycleGO:00073461260.015
cilium morphogenesisGO:00602711020.015
proteolysis involved in cellular protein catabolic processGO:00516031470.015
cellular component assembly involved in morphogenesisGO:00109271390.015
tube formationGO:00351481400.015
regulation of mapk cascadeGO:00434082480.015
negative regulation of intracellular signal transductionGO:19025321670.015
regulation of cell projection organizationGO:00313442060.015
regulation of multi organism processGO:00439001110.015
positive regulation of gtp catabolic processGO:0033126850.015
meiotic cell cycleGO:00513211220.015
regulation of protein catabolic processGO:00421761080.015
peptidyl lysine modificationGO:0018205770.015
cellular response to growth factor stimulusGO:00713631970.015
cardiac chamber developmentGO:00032051080.014
primary neural tube formationGO:0014020950.014
respiratory system developmentGO:00605411900.014
neural tube closureGO:0001843900.014
tube closureGO:0060606910.014
hindbrain developmentGO:00309021280.014
mapk cascadeGO:00001652810.014
histone methylationGO:0016571710.014
ossificationGO:00015032160.014
myeloid cell differentiationGO:00300992330.014
positive regulation of organelle organizationGO:00106381280.014
organophosphate biosynthetic processGO:00904071220.014
Yeast
negative regulation of protein modification processGO:00314001630.014
action potentialGO:0001508780.014
glycoprotein biosynthetic processGO:0009101890.014
cellular protein catabolic processGO:00442571550.014
limb morphogenesisGO:00351081490.014
transmission of nerve impulseGO:0019226760.014
multi multicellular organism processGO:00447061090.014
skin developmentGO:00435882200.014
t cell activationGO:00421102890.014
spermatid developmentGO:00072861080.014
anion transportGO:00068201770.014
regulation of reactive oxygen species metabolic processGO:2000377400.014
regulation of neuron projection developmentGO:00109751690.014
regulation of synaptic growth at neuromuscular junctionGO:000858240.014
response to growth factorGO:00708481980.014
regulation of transferase activityGO:00513382630.014
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.014
regulation of gtp catabolic processGO:00331241130.014
myeloid cell homeostasisGO:00022621140.014
morphogenesis of embryonic epitheliumGO:00163311590.014
telencephalon developmentGO:00215371860.014
regulation of cell growthGO:0001558910.014
regulation of body fluid levelsGO:00508781620.014
cytoplasmic transportGO:00164822340.013
negative regulation of cellular amine metabolic processGO:003323910.013
regulation of defense responseGO:00313472330.013
blood vessel morphogenesisGO:00485142850.013
compound eye developmentGO:004874910.013
cilium assemblyGO:0042384810.013
regulation of reactive oxygen species biosynthetic processGO:190342620.013
regulation of proteolysisGO:00301621640.013
sequestering of calcium ionGO:0051208180.013
limb developmentGO:00601731660.013
negative regulation of phosphorus metabolic processGO:00105631840.013
neuron migrationGO:00017641220.013
neuronal action potentialGO:0019228540.013
blastocyst developmentGO:0001824800.013
Mouse
homeostasis of number of cellsGO:00488722100.013
positive regulation of proteolysisGO:0045862850.013
histone lysine methylationGO:0034968500.013
positive regulation of purine nucleotide catabolic processGO:0033123880.013
cellular alcohol metabolic processGO:004410730.013
sequestering of metal ionGO:0051238190.013
regulation of cellular component biogenesisGO:00440871810.013
regulation of neural precursor cell proliferationGO:2000177700.013
lymphocyte proliferationGO:00466511640.013
locomotory behaviorGO:00076261950.013
neuron deathGO:00709971540.013
organic acid biosynthetic processGO:0016053860.013
cellular chemical homeostasisGO:00550822150.013
positive regulation of nucleoside metabolic processGO:0045979910.013
maternal determination of anterior posterior axis embryoGO:000835820.013
hormone secretionGO:00468791280.013
intracellular protein transportGO:00068862040.013
organelle fissionGO:00482851700.013
reactive nitrogen species metabolic processGO:200105700.013
glucose homeostasisGO:00425931280.013
dna repairGO:00062811070.013
cellular protein complex assemblyGO:00436231160.013
myosin filament assemblyGO:003103420.013
extracellular structure organizationGO:00430621480.013
organelle assemblyGO:00709251770.013
muscle system processGO:00030121410.013
metal ion homeostasisGO:00550651890.012
regulation of vesicle mediated transportGO:00606271390.012
respiratory tube developmentGO:00303231670.012
regulation of nucleotide catabolic processGO:00308111220.012
regulation of homeostatic processGO:00328441820.012
carbohydrate homeostasisGO:00335001280.012
multicellular organism growthGO:00352641610.012
response to inorganic substanceGO:0010035960.012
regulation of cellular component sizeGO:00325351210.012
cellular response to biotic stimulusGO:0071216920.012
negative regulation of phosphate metabolic processGO:00459361840.012
lateral inhibitionGO:004633110.012
positive regulation of nucleotide catabolic processGO:0030813880.012
exocytosisGO:00068871210.012
cellular response to peptide hormone stimulusGO:0071375920.012
stem cell maintenanceGO:00198271300.012
regulation of ras protein signal transductionGO:00465781140.012
myosin filament organizationGO:003103330.012
positive regulation of lymphocyte activationGO:00512511400.012
regulation of kinase activityGO:00435492490.012
chemotaxisGO:00069352470.012
cellular response to nutrient levelsGO:0031669640.012
regulation of stem cell proliferationGO:0072091780.012
positive regulation of cytokine productionGO:00018191740.012
cellular response to peptideGO:1901653920.012
response to light stimulusGO:00094161350.012
modification dependent protein catabolic processGO:00199411330.012
small molecule catabolic processGO:0044282710.012
regulation of establishment of protein localizationGO:00702011810.012
myeloid leukocyte differentiationGO:00025731190.012
negative regulation of cellular amino acid metabolic processGO:004576300.012
response to radiationGO:00093141650.012
stem cell developmentGO:00488642190.012
extracellular matrix organizationGO:00301981470.012
asymmetric stem cell divisionGO:009872230.012
nuclear divisionGO:00002801580.012
steroid metabolic processGO:00082021190.012
central nervous system neuron differentiationGO:00219531620.012
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.012
regulation of system processGO:00440572000.012
divalent inorganic cation transportGO:00725111780.012
regulation of cell morphogenesis involved in differentiationGO:00107691510.011
inflammatory responseGO:00069542440.011
dna recombinationGO:0006310920.011
single organism cell adhesionGO:00986021560.011
fatty acid metabolic processGO:00066311210.011
response to nutrient levelsGO:00316671090.011
Yeast Rat
regulation of protein kinase activityGO:00458592320.011
cell divisionGO:00513011200.011
leukocyte proliferationGO:00706611720.011
canonical wnt signaling pathwayGO:00600701300.011
b cell activationGO:00421131610.011
regulation of t cell activationGO:00508631700.011
cellular response to extracellular stimulusGO:0031668810.011
regulation of protein processingGO:0070613960.011
negative regulation of neuron deathGO:1901215980.011
cation homeostasisGO:00550802120.011
cellular response to external stimulusGO:0071496880.011
regulation of neuron deathGO:19012141340.011
response to extracellular stimulusGO:00099911270.011
Yeast Rat
regulation of wnt signaling pathwayGO:00301111230.011
appendage morphogenesisGO:00351071490.011
cell activation involved in immune responseGO:00022631260.011
regulation of bindingGO:00510981110.011
protein targetingGO:00066051430.011
innate immune responseGO:00450871570.011
cell growthGO:00160491300.011
establishment of organelle localizationGO:00516561220.011
development of primary sexual characteristicsGO:00451371430.011
regulation of cell cycle phase transitionGO:1901987770.011
mitotic cytokinesisGO:000028140.011
engulfment of apoptotic cellGO:004365230.011
regulation of cytoskeleton organizationGO:00514931220.011
digestive system developmentGO:00551232000.011
leukocyte activation involved in immune responseGO:00023661260.011
cellular response to cytokine stimulusGO:00713451890.011
cellular ion homeostasisGO:00068731650.011
male sex differentiationGO:00466611090.011
positive regulation of neuron differentiationGO:00456661410.011
Rat
peptide transportGO:00158331330.011
lung developmentGO:00303241640.011
positive regulation of protein phosphorylationGO:00019342420.011
cognitionGO:00508901490.011
hematopoietic progenitor cell differentiationGO:00022441430.011
carboxylic acid biosynthetic processGO:0046394860.011
positive regulation of ras gtpase activityGO:0032320650.011
amide transportGO:00428861380.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
regulation of protein maturationGO:1903317960.011
positive regulation of cell adhesionGO:0045785800.011
regulation of ras gtpase activityGO:0032318880.011
g1 s transition of mitotic cell cycleGO:0000082570.011
modification dependent macromolecule catabolic processGO:00436321330.011
epidermis developmentGO:00085441870.011
tissue homeostasisGO:00018941150.011
dna modificationGO:0006304500.011
cellular metal ion homeostasisGO:00068751510.011
neuron apoptotic processGO:00514021420.011
regulation of hormone secretionGO:0046883880.011
learning or memoryGO:00076111480.011
connective tissue developmentGO:00614481790.011
cellular response to molecule of bacterial originGO:0071219830.010
dendrite developmentGO:00163581150.010
organic anion transportGO:00157111370.010
response to oxidative stressGO:00069791230.010
protein localization to membraneGO:00726571080.010
negative regulation of neuron apoptotic processGO:0043524920.010
mitochondrion organizationGO:00070051340.010
embryonic appendage morphogenesisGO:00351131260.010
cardiac chamber morphogenesisGO:0003206930.010
meiotic nuclear divisionGO:00071261150.010
negative regulation of protein processingGO:0010955790.010
anatomical structure homeostasisGO:00602491450.010
cell cycle g1 s phase transitionGO:0044843570.010
cellular response to acid chemicalGO:0071229680.010
negative regulation of protein phosphorylationGO:00019331260.010
sulfur compound metabolic processGO:00067901000.010
negative regulation of phosphorylationGO:00423261660.010
negative regulation of organelle organizationGO:0010639900.010
adult behaviorGO:00305341350.010
fertilizationGO:00095661270.010
establishment or maintenance of cytoskeleton polarityGO:003095220.010
organic hydroxy compound biosynthetic processGO:1901617770.010
extrinsic apoptotic signaling pathwayGO:00971911260.010
urogenital system developmentGO:00016552610.010
rna interferenceGO:001624620.010
fat cell differentiationGO:00454441600.010
cytokinetic processGO:003250620.010
negative regulation of gene silencingGO:006096920.010
peptide secretionGO:00027901140.010
calcium ion transportGO:00068161590.010
bone developmentGO:00603481200.010
ear developmentGO:00435832000.010
cellular response to lipopolysaccharideGO:0071222770.010

Kdm4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.026
nervous system diseaseDOID:86300.026
disease of metabolismDOID:001466700.017
central nervous system diseaseDOID:33100.015
disease of cellular proliferationDOID:1456600.014
organ system cancerDOID:005068600.014
cancerDOID:16200.014
inherited metabolic disorderDOID:65500.012
musculoskeletal system diseaseDOID:1700.010
immune system diseaseDOID:291400.010