Mus musculus

85 known processes

Lrdd

leucine-rich and death domain containing

(Aliases: AU042446,1200011D09Rik,Pidd)

Lrdd biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
dna metabolic processGO:00062593030.157
cellular response to dna damage stimulusGO:00069742070.133
Human
lymphocyte differentiationGO:00300982420.113
cellular amino acid metabolic processGO:00065201030.095
apoptotic signaling pathwayGO:00971903060.085
regulation of cell cycle processGO:00105641600.081
Human
t cell activationGO:00421102890.065
regulation of cell activationGO:00508652890.063
homeostasis of number of cellsGO:00488722100.058
oxidation reduction processGO:00551143420.056
ras protein signal transductionGO:0007265770.056
positive regulation of apoptotic processGO:00430652170.055
response to organonitrogen compoundGO:00102432460.054
regulation of cytokine productionGO:00018172660.054
regulation of apoptotic signaling pathwayGO:20012331970.053
organelle assemblyGO:00709251770.052
regulation of cell cycleGO:00517262810.052
Human
meiotic nuclear divisionGO:00071261150.050
positive regulation of programmed cell deathGO:00430682180.049
microtubule based processGO:00070172360.049
positive regulation of cellular amino acid metabolic processGO:004576430.048
organelle fissionGO:00482851700.048
regulation of organelle organizationGO:00330432890.047
macromolecule catabolic processGO:00090572810.047
regulation of lymphocyte activationGO:00512492400.045
meiotic cell cycleGO:00513211220.045
regulation of cellular ketone metabolic processGO:0010565660.044
cellular ketone metabolic processGO:0042180840.044
cytokine productionGO:00018163190.044
regulation of cellular amino acid metabolic processGO:000652150.043
gland developmentGO:00487323300.043
rho protein signal transductionGO:0007266320.043
lymphocyte proliferationGO:00466511640.042
negative regulation of cellular component organizationGO:00511291940.042
leukocyte differentiationGO:00025213420.041
protein maturationGO:00516041760.041
leukocyte proliferationGO:00706611720.041
heterocycle catabolic processGO:00467002800.040
cellular component assembly involved in morphogenesisGO:00109271390.040
negative regulation of cell proliferationGO:00082852960.040
male gamete generationGO:00482322850.040
purine nucleoside catabolic processGO:00061522050.039
dna integrity checkpointGO:0031570280.039
Human
cation transportGO:00068123990.038
membrane organizationGO:00610242450.038
regulation of cellular amine metabolic processGO:0033238200.038
small gtpase mediated signal transductionGO:0007264970.037
transmembrane transportGO:00550854120.037
b cell activationGO:00421131610.036
striated muscle tissue developmentGO:00147062930.035
negative regulation of immune system processGO:00026832090.035
neuron deathGO:00709971540.035
cellular amine metabolic processGO:0044106440.035
mitotic cell cycleGO:00002781950.034
Human
microtubule cytoskeleton organizationGO:00002261570.034
g1 s transition of mitotic cell cycleGO:0000082570.034
Human
spermatogenesisGO:00072832840.033
germ cell developmentGO:00072811850.033
extrinsic apoptotic signaling pathwayGO:00971911260.033
purine nucleotide metabolic processGO:00061633020.032
skeletal system morphogenesisGO:00487052030.032
ion transmembrane transportGO:00342203610.032
nuclear divisionGO:00002801580.031
negative regulation of organelle organizationGO:0010639900.031
peptidyl amino acid modificationGO:00181933360.031
negative regulation of cell cycleGO:00457861230.030
Human
regulation of secretion by cellGO:19035302490.030
nucleobase containing small molecule metabolic processGO:00550863520.030
forebrain developmentGO:00309003020.030
immune effector processGO:00022523210.029
regulation of cellular component sizeGO:00325351210.029
skeletal system developmentGO:00015013560.029
endomembrane system organizationGO:00102561470.029
positive regulation of lymphocyte activationGO:00512511400.029
cell type specific apoptotic processGO:00972852680.029
positive regulation of proteolysisGO:0045862850.029
protein catabolic processGO:00301632210.028
negative regulation of protein modification processGO:00314001630.028
myeloid cell differentiationGO:00300992330.028
nucleoside triphosphate metabolic processGO:00091412300.028
positive regulation of cell deathGO:00109422240.028
regulation of cellular response to stressGO:00801351590.028
regulation of anatomical structure sizeGO:00900661780.028
hematopoietic progenitor cell differentiationGO:00022441430.028
negative regulation of protein metabolic processGO:00512482820.028
response to cell cycle checkpoint signalingGO:007239610.028
positive regulation of cellular amine metabolic processGO:003324050.027
purine ribonucleotide catabolic processGO:00091542080.027
compound eye developmentGO:004874910.027
locomotory behaviorGO:00076261950.027
aromatic compound catabolic processGO:00194392860.027
ribonucleoside metabolic processGO:00091192450.027
synaptic transmissionGO:00072683290.027
regulation of leukocyte differentiationGO:19021051590.027
leukocyte migrationGO:00509001240.026
positive regulation of cell cycle processGO:0090068610.026
Human
actin cytoskeleton organizationGO:00300362200.025
embryonic skeletal system developmentGO:00487061200.025
blood vessel morphogenesisGO:00485142850.025
negative regulation of cellular protein metabolic processGO:00322692470.025
positive regulation of cellular catabolic processGO:00313311480.025
protein processingGO:00164851630.025
regulation of mapk cascadeGO:00434082480.025
positive regulation of cell developmentGO:00107202370.025
amine metabolic processGO:0009308450.025
regulation of membrane potentialGO:00423911920.024
regulation of lymphocyte proliferationGO:00506701170.024
organophosphate catabolic processGO:00464342320.024
central nervous system neuron differentiationGO:00219531620.023
negative regulation of cellular amino acid metabolic processGO:004576300.023
negative regulation of nervous system developmentGO:00519611560.023
mapk cascadeGO:00001652810.023
digestive system developmentGO:00551232000.023
divalent metal ion transportGO:00708381720.023
muscle tissue developmentGO:00605373080.023
regulation of fat cell differentiationGO:0045598810.023
regulation of cell cycle g1 s phase transitionGO:1902806350.023
Human
regulation of transmembrane transportGO:00347621280.023
regulation of t cell activationGO:00508631700.022
regulation of proteolysisGO:00301621640.022
digestive tract developmentGO:00485651900.022
reactive oxygen species metabolic processGO:0072593840.022
nucleoside phosphate metabolic processGO:00067533380.022
calcium ion transportGO:00068161590.022
multicellular organismal homeostasisGO:00488711640.022
adaptive immune responseGO:00022501550.022
cytokinetic processGO:003250620.022
t cell proliferationGO:00420981200.022
cellular lipid metabolic processGO:00442553230.022
positive regulation of leukocyte differentiationGO:1902107860.021
neuron apoptotic processGO:00514021420.021
lymphocyte mediated immunityGO:00024491390.021
energy derivation by oxidation of organic compoundsGO:0015980770.021
regulation of homeostatic processGO:00328441820.021
regulation of leukocyte proliferationGO:00706631210.021
learning or memoryGO:00076111480.021
t cell differentiationGO:00302171740.021
negative regulation of cellular amine metabolic processGO:003323910.021
regulation of cellular catabolic processGO:00313292420.021
positive regulation of hydrolase activityGO:00513451480.020
cartilage developmentGO:00512161400.020
glycosyl compound metabolic processGO:19016572460.020
positive regulation of endopeptidase activityGO:0010950430.020
spermatid developmentGO:00072861080.020
cellular response to organonitrogen compoundGO:00714171450.020
ossificationGO:00015032160.020
regulation of mitotic cell cycle phase transitionGO:1901990730.020
Human
skeletal muscle organ developmentGO:00605381630.020
rhythmic processGO:00485111740.020
regulation of cell cycle phase transitionGO:1901987770.020
Human
regulation of defense responseGO:00313472330.019
ribonucleotide metabolic processGO:00092592910.019
cytokine mediated signaling pathwayGO:00192211150.019
cellular macromolecule catabolic processGO:00442652060.019
connective tissue developmentGO:00614481790.019
defense response to virusGO:0051607680.019
divalent inorganic cation transportGO:00725111780.019
regionalizationGO:00030023370.019
organelle localizationGO:00516401790.019
cellular response to cytokine stimulusGO:00713451890.019
regulation of protein catabolic processGO:00421761080.019
limb morphogenesisGO:00351081490.019
positive regulation of cell activationGO:00508671580.019
negative regulation of phosphorus metabolic processGO:00105631840.019
regulation of cellular component biogenesisGO:00440871810.019
positive regulation of leukocyte proliferationGO:0070665730.019
establishment or maintenance of cytoskeleton polarityGO:003095220.019
nucleoside triphosphate catabolic processGO:00091432050.019
positive regulation of neuron differentiationGO:00456661410.019
muscle cell differentiationGO:00426922610.019
male meiosisGO:0007140370.019
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.019
organonitrogen compound biosynthetic processGO:19015661920.019
purine ribonucleoside triphosphate catabolic processGO:00092071990.019
morphogenesis of a branching structureGO:00017632030.018
ribonucleoside triphosphate metabolic processGO:00091992200.018
regulation of interleukin 8 productionGO:003267730.018
purine ribonucleotide metabolic processGO:00091502900.018
cellular ion homeostasisGO:00068731650.018
generation of precursor metabolites and energyGO:00060911030.018
response to radiationGO:00093141650.018
t cell differentiation in thymusGO:0033077770.018
cellular response to biotic stimulusGO:0071216920.018
morphogenesis of a branching epitheliumGO:00611381930.018
germ line stem cell divisionGO:004207820.018
ribose phosphate metabolic processGO:00196932910.018
sensory organ morphogenesisGO:00905962420.018
interleukin 8 productionGO:003263740.018
camera type eye developmentGO:00430102660.018
purine nucleotide catabolic processGO:00061952110.018
dna damage checkpointGO:0000077260.018
Human
fat cell differentiationGO:00454441600.017
organonitrogen compound catabolic processGO:19015652640.017
b cell differentiationGO:0030183780.017
regulation of secretionGO:00510462740.017
regulation of t cell proliferationGO:0042129920.017
dna biosynthetic processGO:0071897220.017
purine ribonucleoside catabolic processGO:00461302050.017
regulation of protein serine threonine kinase activityGO:00719001570.017
positive regulation of organelle organizationGO:00106381280.017
negative regulation of cell cycle phase transitionGO:1901988480.017
Human
intrinsic apoptotic signaling pathwayGO:00971931320.017
modification dependent macromolecule catabolic processGO:00436321330.017
bone developmentGO:00603481200.017
negative regulation of molecular functionGO:00440922580.017
microtubule polymerization or depolymerizationGO:0031109260.017
lymphocyte activation involved in immune responseGO:0002285930.017
nucleoside phosphate catabolic processGO:19012922220.017
chromatin organizationGO:00063252060.017
limb developmentGO:00601731660.017
purine nucleoside metabolic processGO:00422782410.017
regulation of lymphocyte mediated immunityGO:0002706840.017
myosin filament assemblyGO:003103420.017
negative regulation of cell developmentGO:00107211690.017
regulation of reactive oxygen species metabolic processGO:2000377400.017
cellular protein complex assemblyGO:00436231160.017
regulation of cell cycle g2 m phase transitionGO:1902749100.016
thymus developmentGO:0048538410.016
regulation of hydrolase activityGO:00513362460.016
regulation of cell motilityGO:20001452360.016
intracellular protein transportGO:00068862040.016
mitotic cell cycle processGO:19030471590.016
Human
regulation of neuron differentiationGO:00456642810.016
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.016
negative regulation of phosphate metabolic processGO:00459361840.016
neuroblast differentiationGO:001401620.016
dna endoreduplicationGO:004202340.016
angiogenesisGO:00015252010.016
positive regulation of t cell activationGO:00508701010.016
nucleotide metabolic processGO:00091173320.016
positive regulation of cell cycleGO:0045787920.016
Human
positive regulation of protein phosphorylationGO:00019342420.016
ribonucleotide catabolic processGO:00092612080.016
posttranscriptional regulation of gene expressionGO:00106081550.016
leukocyte mediated cytotoxicityGO:0001909620.016
intestinal epithelial structure maintenanceGO:006072940.016
purine containing compound metabolic processGO:00725213110.016
regulation of body fluid levelsGO:00508781620.016
regulation of adaptive immune responseGO:0002819900.015
regulation of lymphocyte differentiationGO:00456191070.015
carbohydrate derivative catabolic processGO:19011362310.015
epithelial cell developmentGO:00020641590.015
circulatory system processGO:00030131970.015
cell cycle g1 s phase transitionGO:0044843570.015
Human
purine nucleoside triphosphate metabolic processGO:00091442260.015
g protein coupled acetylcholine receptor signaling pathwayGO:000721340.015
regulation of g1 s transition of mitotic cell cycleGO:2000045350.015
Human
myeloid leukocyte differentiationGO:00025731190.015
positive regulation of nervous system developmentGO:00519622210.015
appendage developmentGO:00487361660.015
regulation of ossificationGO:00302781120.015
dephosphorylationGO:00163111290.015
multicellular organism growthGO:00352641610.015
dna repairGO:00062811070.015
regulation of chromosome organizationGO:0033044830.015
cytoplasmic transportGO:00164822340.015
regulation of protein kinase activityGO:00458592320.015
defecationGO:003042110.015
purine ribonucleoside metabolic processGO:00461282410.015
response to organic cyclic compoundGO:00140701980.015
double strand break repairGO:0006302480.015
regulation of transferase activityGO:00513382630.014
cellular carbohydrate metabolic processGO:00442621190.014
negative regulation of cell cycle processGO:0010948690.014
Human
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.014
regulation of system processGO:00440572000.014
regulation of cytoskeleton organizationGO:00514931220.014
leukocyte mediated immunityGO:00024431740.014
development of primary sexual characteristicsGO:00451371430.014
purine ribonucleoside triphosphate metabolic processGO:00092052200.014
cognitionGO:00508901490.014
cell adhesionGO:00071553290.014
positive regulation of myeloid cell differentiationGO:0045639430.014
positive regulation of transferase activityGO:00513471670.014
cell divisionGO:00513011200.014
cellular response to lipopolysaccharideGO:0071222770.014
striated muscle cell developmentGO:00550021250.014
positive regulation of t cell proliferationGO:0042102520.014
positive regulation of cell cycle phase transitionGO:1901989170.014
glycosylationGO:0070085620.014
positive regulation of interleukin 8 productionGO:003275720.014
nucleotide catabolic processGO:00091662170.014
organic anion transportGO:00157111370.014
negative regulation of dna replicationGO:000815640.014
extracellular structure organizationGO:00430621480.013
endocytosisGO:00068971680.013
embryonic organ morphogenesisGO:00485622760.013
carbohydrate metabolic processGO:00059752300.013
protein modification by small protein conjugation or removalGO:00706472070.013
sensory perceptionGO:00076002450.013
organic cyclic compound catabolic processGO:19013612950.013
dna recombinationGO:0006310920.013
oocyte axis specificationGO:000730920.013
inflammatory responseGO:00069542440.013
regulation of kinase activityGO:00435492490.013
epithelial tube morphogenesisGO:00605623030.013
nucleoside catabolic processGO:00091642060.013
positive regulation of mapk cascadeGO:00434101700.013
cell fate commitmentGO:00451652100.013
cell cycle checkpointGO:0000075470.013
Human
regulation of ubiquitin protein ligase activity involved in mitotic cell cycleGO:005143910.013
ribonucleoside triphosphate catabolic processGO:00092031990.013
carboxylic acid biosynthetic processGO:0046394860.013
protein ubiquitinationGO:00165671710.013
positive regulation of cell projection organizationGO:0031346950.013
negative regulation of mitotic cell cycleGO:0045930580.013
Human
meiotic cell cycle processGO:1903046770.013
regulation of purine nucleotide metabolic processGO:19005421690.013
cellularizationGO:000734910.013
response to transforming growth factor betaGO:0071559880.013
myosin filament organizationGO:003103330.013
cellular glucan metabolic processGO:0006073320.012
lymphocyte apoptotic processGO:0070227540.012
female gamete generationGO:0007292740.012
lateral inhibitionGO:004633110.012
nuclear transportGO:00511691390.012
regulation of mitotic cell cycleGO:00073461260.012
Human
peptidyl serine modificationGO:0018209830.012
negative regulation of lymphocyte activationGO:0051250910.012
ribonucleoside catabolic processGO:00424542060.012
regulation of ion transportGO:00432692150.012
negative regulation of transferase activityGO:0051348850.012
modification dependent protein catabolic processGO:00199411330.012
positive regulation of protein modification processGO:00314012990.012
nucleic acid phosphodiester bond hydrolysisGO:0090305490.012
positive regulation of mitotic cell cycle phase transitionGO:1901992170.012
oocyte constructionGO:000730820.012
anatomical structure homeostasisGO:00602491450.012
regulation of myeloid leukocyte differentiationGO:0002761580.012
fertilizationGO:00095661270.012
morphogenesis of embryonic epitheliumGO:00163311590.012
regulation of cell migrationGO:00303342190.012
inorganic cation transmembrane transportGO:00986622070.012
neuroblast fate commitmentGO:001401710.012
chromosome organization involved in meiosisGO:0070192390.012
response to lipopolysaccharideGO:00324961280.012
regulation of ras gtpase activityGO:0032318880.012
respiratory tube developmentGO:00303231670.012
cellular response to growth factor stimulusGO:00713631970.012
negative regulation of intracellular signal transductionGO:19025321670.012
purine nucleoside triphosphate catabolic processGO:00091462030.012
negative regulation of apoptotic signaling pathwayGO:20012341040.012
regulation of leukocyte mediated cytotoxicityGO:0001910380.012
positive regulation of cytokine productionGO:00018191740.012
regulation of cell sizeGO:0008361720.012
response to acid chemicalGO:00011011110.012
hexose metabolic processGO:0019318980.012
maintenance of locationGO:0051235890.012
regulation of establishment of protein localizationGO:00702011810.012
regulation of hormone levelsGO:00108172110.012
carbohydrate derivative biosynthetic processGO:19011371830.012
macromolecule methylationGO:00434141200.012
wnt signaling pathwayGO:00160551880.012
chromosome segregationGO:0007059480.012
monocarboxylic acid metabolic processGO:00327871910.012
regulation of metal ion transportGO:00109591060.012
regulation of neuron apoptotic processGO:00435231220.011
regulation of innate immune responseGO:0045088910.011
regulation of endopeptidase activityGO:0052548890.011
response to insulinGO:00328681000.011
nucleoside metabolic processGO:00091162460.011
regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:1902041220.011
lymphocyte homeostasisGO:0002260640.011
organic acid biosynthetic processGO:0016053860.011
ear developmentGO:00435832000.011
regulation of nucleotide metabolic processGO:00061401690.011
anion transportGO:00068201770.011
exocytosisGO:00068871210.011
regulation of multi organism processGO:00439001110.011
regulation of ion transmembrane transportGO:00347651190.011
cytokine biosynthetic processGO:0042089680.011
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.011
b cell activation involved in immune responseGO:0002312500.011
regulation of b cell activationGO:0050864810.011
rna processingGO:00063961050.011
negative regulation of phosphorylationGO:00423261660.011
regulation of protein localizationGO:00328802310.011
cellular nitrogen compound catabolic processGO:00442702800.011
gonad developmentGO:00084061410.011
cilium morphogenesisGO:00602711020.011
skin developmentGO:00435882200.011
chondrocyte differentiationGO:0002062720.011
regulation of myeloid cell differentiationGO:0045637960.011
regulation of cell projection organizationGO:00313442060.011
mitochondrion organizationGO:00070051340.011
regulation of circadian rhythmGO:0042752580.011
columnar cuboidal epithelial cell differentiationGO:0002065820.011
cell killingGO:0001906670.011
regulation of proteolysis involved in cellular protein catabolic processGO:1903050560.011
embryonic skeletal system morphogenesisGO:0048704910.011
positive regulation of lymphocyte proliferationGO:0050671700.011
cellular response to lipidGO:00713961450.011
positive regulation of secretionGO:00510471300.011
cell growthGO:00160491300.011
nucleoside monophosphate metabolic processGO:0009123850.011
schwann cell proliferationGO:001401020.011
inorganic ion transmembrane transportGO:00986602340.011
regulation of response to woundingGO:19030341890.011
amide transportGO:00428861380.011
pallium developmentGO:00215431200.011
triglyceride metabolic processGO:0006641510.011
metaphase plate congressionGO:005131020.011
neuroepithelial cell differentiationGO:0060563370.011
nucleus organizationGO:0006997450.011
regulation of synaptic growth at neuromuscular junctionGO:000858240.011
mrna metabolic processGO:0016071840.010
extracellular matrix organizationGO:00301981470.010
fatty acid metabolic processGO:00066311210.010
actin filament organizationGO:00070151130.010
response to molecule of bacterial originGO:00022371430.010
positive regulation of nucleotide metabolic processGO:00459811140.010
regulation of protein bindingGO:0043393600.010
embryonic limb morphogenesisGO:00303261260.010
glycoprotein metabolic processGO:00091001160.010
monosaccharide metabolic processGO:00059961060.010
negative regulation of cell activationGO:00508661110.010
protein modification by small protein conjugationGO:00324461870.010
response to drugGO:0042493750.010
leukocyte apoptotic processGO:0071887710.010
negative regulation of neuron differentiationGO:00456651010.010
liver developmentGO:0001889660.010
embryonic digestive tract developmentGO:0048566270.010
innate immune responseGO:00450871570.010
actomyosin structure organizationGO:0031032560.010
developmental maturationGO:00217001930.010
cell maturationGO:00484691270.010
regulation of interferon gamma productionGO:0032649570.010
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrestGO:000697730.010
Human
reciprocal dna recombinationGO:0035825160.010

Lrdd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.054
immune system diseaseDOID:291400.054
congenital hypoplastic anemiaDOID:134200.017
hematopoietic system diseaseDOID:7400.017
aplastic anemiaDOID:1244900.017
anemiaDOID:235500.017
bone marrow diseaseDOID:496100.017
cancerDOID:16200.014
disease of cellular proliferationDOID:1456600.014
organ system cancerDOID:005068600.014
nervous system diseaseDOID:86300.011