Mus musculus

0 known processes

Eif2c4

eukaryotic translation initiation factor 2C, 4

(Aliases: KIAA1567,5730550L01Rik,Ago4,AI481660)

Eif2c4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
purine nucleotide metabolic processGO:00061633020.065
small gtpase mediated signal transductionGO:0007264970.061
nucleobase containing small molecule metabolic processGO:00550863520.060
regulation of cellular amino acid metabolic processGO:000652150.059
cellular amino acid metabolic processGO:00065201030.059
organic cyclic compound catabolic processGO:19013612950.058
Human
amine metabolic processGO:0009308450.056
ribonucleoside metabolic processGO:00091192450.056
cellular amine metabolic processGO:0044106440.055
heterocycle catabolic processGO:00467002800.053
Human
nucleotide metabolic processGO:00091173320.052
glycosyl compound metabolic processGO:19016572460.051
regulation of cellular amine metabolic processGO:0033238200.051
ras protein signal transductionGO:0007265770.051
ribose phosphate metabolic processGO:00196932910.050
regulation of cellular ketone metabolic processGO:0010565660.049
ribonucleotide metabolic processGO:00092592910.048
ribonucleoside triphosphate catabolic processGO:00092031990.047
aromatic compound catabolic processGO:00194392860.047
Human
ribonucleoside catabolic processGO:00424542060.046
purine nucleoside catabolic processGO:00061522050.045
purine nucleoside triphosphate metabolic processGO:00091442260.045
nucleoside catabolic processGO:00091642060.045
organophosphate catabolic processGO:00464342320.045
purine ribonucleoside catabolic processGO:00461302050.044
nucleoside phosphate metabolic processGO:00067533380.044
membrane organizationGO:00610242450.044
nucleoside phosphate catabolic processGO:19012922220.044
purine containing compound metabolic processGO:00725213110.043
ribonucleoside triphosphate metabolic processGO:00091992200.043
positive regulation of cellular amino acid metabolic processGO:004576430.043
nucleotide catabolic processGO:00091662170.042
cellular ketone metabolic processGO:0042180840.042
positive regulation of cellular catabolic processGO:00313311480.042
regulation of neuron differentiationGO:00456642810.041
cellular nitrogen compound catabolic processGO:00442702800.041
Human
rho protein signal transductionGO:0007266320.041
purine containing compound catabolic processGO:00725232130.041
regulation of cellular catabolic processGO:00313292420.040
organonitrogen compound catabolic processGO:19015652640.040
nucleoside metabolic processGO:00091162460.040
macromolecule catabolic processGO:00090572810.039
Human
microtubule based processGO:00070172360.038
forebrain developmentGO:00309003020.037
purine nucleoside metabolic processGO:00422782410.037
positive regulation of cellular amine metabolic processGO:003324050.036
transmembrane transportGO:00550854120.036
nucleoside triphosphate catabolic processGO:00091432050.036
guanosine containing compound catabolic processGO:19010691440.036
purine ribonucleotide metabolic processGO:00091502900.036
purine ribonucleoside triphosphate metabolic processGO:00092052200.036
purine nucleotide catabolic processGO:00061952110.036
purine ribonucleoside triphosphate catabolic processGO:00092071990.035
regulation of hydrolase activityGO:00513362460.035
regulation of nucleotide metabolic processGO:00061401690.035
guanosine containing compound metabolic processGO:19010681440.034
purine ribonucleotide catabolic processGO:00091542080.034
regulation of nucleoside metabolic processGO:00091181300.034
actin cytoskeleton organizationGO:00300362200.034
male gamete generationGO:00482322850.033
skeletal system developmentGO:00015013560.033
regulation of nucleotide catabolic processGO:00308111220.033
carbohydrate derivative catabolic processGO:19011362310.032
muscle tissue developmentGO:00605373080.032
dephosphorylationGO:00163111290.032
positive regulation of hydrolase activityGO:00513451480.032
nucleoside triphosphate metabolic processGO:00091412300.032
negative regulation of cellular component organizationGO:00511291940.031
purine nucleoside triphosphate catabolic processGO:00091462030.030
gtp metabolic processGO:00460391440.030
muscle cell differentiationGO:00426922610.030
ossificationGO:00015032160.029
regulation of purine nucleotide catabolic processGO:00331211220.029
purine ribonucleoside metabolic processGO:00461282410.028
cation transportGO:00068123990.028
striated muscle tissue developmentGO:00147062930.028
cellular component assembly involved in morphogenesisGO:00109271390.028
protein catabolic processGO:00301632210.028
response to organonitrogen compoundGO:00102432460.028
leukocyte differentiationGO:00025213420.028
regulation of organelle organizationGO:00330432890.028
positive regulation of protein modification processGO:00314012990.027
cellular response to organonitrogen compoundGO:00714171450.027
camera type eye developmentGO:00430102660.027
glycosyl compound catabolic processGO:19016582060.027
gland developmentGO:00487323300.027
regulation of neuron projection developmentGO:00109751690.027
ribonucleotide catabolic processGO:00092612080.026
peptidyl amino acid modificationGO:00181933360.026
organelle assemblyGO:00709251770.026
regulation of cell projection organizationGO:00313442060.026
protein modification by small protein conjugation or removalGO:00706472070.026
response to growth factorGO:00708481980.026
mapk cascadeGO:00001652810.026
ion transmembrane transportGO:00342203610.026
homeostasis of number of cellsGO:00488722100.026
organelle localizationGO:00516401790.025
spermatogenesisGO:00072832840.025
epithelial tube morphogenesisGO:00605623030.025
posttranscriptional regulation of gene expressionGO:00106081550.025
Human
positive regulation of nervous system developmentGO:00519622210.025
regulation of mapk cascadeGO:00434082480.024
regulation of purine nucleotide metabolic processGO:19005421690.024
maintenance of locationGO:0051235890.024
cellular protein catabolic processGO:00442571550.024
protein ubiquitinationGO:00165671710.024
positive regulation of nucleotide metabolic processGO:00459811140.024
cellular protein complex assemblyGO:00436231160.024
regulation of cell activationGO:00508652890.024
negative regulation of protein metabolic processGO:00512482820.024
Human
g protein coupled receptor signaling pathwayGO:00071862430.024
regionalizationGO:00030023370.023
cytoplasmic transportGO:00164822340.023
regulation of homeostatic processGO:00328441820.023
regulation of anatomical structure sizeGO:00900661780.023
positive regulation of purine nucleotide catabolic processGO:0033123880.023
negative regulation of cellular amine metabolic processGO:003323910.022
negative regulation of intracellular signal transductionGO:19025321670.022
positive regulation of cell developmentGO:00107202370.022
regulation of lymphocyte activationGO:00512492400.022
positive regulation of purine nucleotide metabolic processGO:19005441140.022
t cell activationGO:00421102890.022
regulation of gtp catabolic processGO:00331241130.022
multicellular organism growthGO:00352641610.022
negative regulation of cellular amino acid metabolic processGO:004576300.022
cell type specific apoptotic processGO:00972852680.022
gtp catabolic processGO:00061841430.021
lymphocyte differentiationGO:00300982420.021
positive regulation of gtp catabolic processGO:0033126850.021
myosin filament assemblyGO:003103420.021
multicellular organismal signalingGO:0035637910.021
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.021
immune effector processGO:00022523210.021
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.021
axonogenesisGO:00074092740.021
protein modification by small protein conjugationGO:00324461870.021
regulation of protein localizationGO:00328802310.021
regulation of cellular component biogenesisGO:00440871810.020
digestive system developmentGO:00551232000.020
positive regulation of programmed cell deathGO:00430682180.020
renal system developmentGO:00720012250.020
cellular homeostasisGO:00197252400.020
telencephalon developmentGO:00215371860.020
cell adhesionGO:00071553290.020
nitrogen compound transportGO:00717052710.020
regulation of secretion by cellGO:19035302490.020
endomembrane system organizationGO:00102561470.020
cytokine productionGO:00018163190.020
positive regulation of nucleoside metabolic processGO:0045979910.020
positive regulation of nucleotide catabolic processGO:0030813880.020
apoptotic signaling pathwayGO:00971903060.019
regulation of ras protein signal transductionGO:00465781140.019
cation transmembrane transportGO:00986552660.019
organic hydroxy compound metabolic processGO:19016152030.019
regulation of intracellular transportGO:00323861590.019
negative regulation of cellular protein metabolic processGO:00322692470.019
Human
regulation of secretionGO:00510462740.019
positive regulation of ras gtpase activityGO:0032320650.019
positive regulation of protein phosphorylationGO:00019342420.019
regulation of apoptotic signaling pathwayGO:20012331970.019
myosin filament organizationGO:003103330.019
negative regulation of cell proliferationGO:00082852960.019
regulation of hormone levelsGO:00108172110.019
cellular response to lipidGO:00713961450.019
sensory organ morphogenesisGO:00905962420.019
regulation of cellular component sizeGO:00325351210.019
negative regulation of phosphorus metabolic processGO:00105631840.019
regulation of synaptic growth at neuromuscular junctionGO:000858240.019
embryonic organ morphogenesisGO:00485622760.019
regulation of actin filament based processGO:0032970990.019
response to radiationGO:00093141650.019
heart morphogenesisGO:00030071780.018
regulation of membrane potentialGO:00423911920.018
inorganic ion transmembrane transportGO:00986602340.018
morphogenesis of embryonic epitheliumGO:00163311590.018
cellular chemical homeostasisGO:00550822150.018
regulation of cell cycleGO:00517262810.018
positive regulation of apoptotic processGO:00430652170.018
circulatory system processGO:00030131970.018
synaptic transmissionGO:00072683290.018
mitotic cell cycle processGO:19030471590.018
oxidation reduction processGO:00551143420.018
cellular response to hormone stimulusGO:00328701500.018
protein localization to membraneGO:00726571080.018
microtubule cytoskeleton organizationGO:00002261570.018
skeletal muscle organ developmentGO:00605381630.018
regulation of cytoskeleton organizationGO:00514931220.017
striated muscle myosin thick filament assemblyGO:007168810.017
positive regulation of organelle organizationGO:00106381280.017
limb developmentGO:00601731660.017
modification dependent protein catabolic processGO:00199411330.017
negative regulation of nervous system developmentGO:00519611560.017
regulation of transferase activityGO:00513382630.017
inorganic cation transmembrane transportGO:00986622070.017
dna metabolic processGO:00062593030.017
proteolysis involved in cellular protein catabolic processGO:00516031470.017
locomotory behaviorGO:00076261950.017
regulation of t cell activationGO:00508631700.017
blood circulationGO:00080151950.017
blood vessel morphogenesisGO:00485142850.017
developmental maturationGO:00217001930.017
reactive oxygen species metabolic processGO:0072593840.017
regulation of ras gtpase activityGO:0032318880.017
organonitrogen compound biosynthetic processGO:19015661920.017
regulation of cell morphogenesis involved in differentiationGO:00107691510.017
negative regulation of molecular functionGO:00440922580.017
negative regulation of phosphate metabolic processGO:00459361840.016
hematopoietic progenitor cell differentiationGO:00022441430.016
developmental growth involved in morphogenesisGO:00605601380.016
cellular macromolecule catabolic processGO:00442652060.016
Human
urogenital system developmentGO:00016552610.016
positive regulation of gtpase activityGO:0043547850.016
protein maturationGO:00516041760.016
myotube differentiationGO:00149021050.016
modification dependent macromolecule catabolic processGO:00436321330.016
wnt signaling pathwayGO:00160551880.016
alpha beta t cell activationGO:0046631910.016
regulation of system processGO:00440572000.016
carbohydrate metabolic processGO:00059752300.016
stem cell differentiationGO:00488632680.016
chromatin organizationGO:00063252060.016
tube formationGO:00351481400.016
cellular response to dna damage stimulusGO:00069742070.016
cilium morphogenesisGO:00602711020.016
positive regulation of cell deathGO:00109422240.016
limb morphogenesisGO:00351081490.015
germ cell developmentGO:00072811850.015
regulation of defense responseGO:00313472330.015
positive regulation of transferase activityGO:00513471670.015
regulation of protein transportGO:00512231630.015
response to organic cyclic compoundGO:00140701980.015
neuronal action potentialGO:0019228540.015
angiogenesisGO:00015252010.015
skeletal system morphogenesisGO:00487052030.015
metencephalon developmentGO:0022037890.015
divalent inorganic cation transportGO:00725111780.015
embryonic epithelial tube formationGO:00018381300.015
ubiquitin dependent protein catabolic processGO:00065111290.015
negative regulation of cell developmentGO:00107211690.015
regulation of cell motilityGO:20001452360.015
cation homeostasisGO:00550802120.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.015
kidney developmentGO:00018222130.015
negative regulation of immune system processGO:00026832090.015
regulation of establishment of protein localizationGO:00702011810.015
response to light stimulusGO:00094161350.015
protein targetingGO:00066051430.015
multi multicellular organism processGO:00447061090.015
action potentialGO:0001508780.015
regulation of cellular response to stressGO:00801351590.015
positive regulation of neuron differentiationGO:00456661410.015
mitotic cell cycleGO:00002781950.015
cellular ion homeostasisGO:00068731650.015
myeloid cell differentiationGO:00300992330.015
regulation of kinase activityGO:00435492490.015
chemotaxisGO:00069352470.015
neural tube developmentGO:00219151600.015
protein localization to nucleusGO:00345041210.015
morphogenesis of a branching epitheliumGO:00611381930.014
retina development in camera type eyeGO:00600411190.014
leukocyte mediated immunityGO:00024431740.014
protein localization to organelleGO:00333651850.014
sensory perceptionGO:00076002450.014
cellular response to biotic stimulusGO:0071216920.014
amide transportGO:00428861380.014
adaptive immune responseGO:00022501550.014
respiratory system developmentGO:00605411900.014
lipid localizationGO:00108761260.014
intracellular protein transportGO:00068862040.014
lateral inhibitionGO:004633110.014
lymphocyte proliferationGO:00466511640.014
regulation of protein kinase activityGO:00458592320.014
muscle system processGO:00030121410.014
multicellular organismal homeostasisGO:00488711640.014
cellular response to growth factor stimulusGO:00713631970.014
cellular response to cytokine stimulusGO:00713451890.014
t cell differentiationGO:00302171740.014
dendrite developmentGO:00163581150.014
regulation of bindingGO:00510981110.014
protein polymerizationGO:0051258570.014
response to molecule of bacterial originGO:00022371430.014
methylationGO:00322591340.014
lymphocyte mediated immunityGO:00024491390.014
synapse organizationGO:00508081250.014
sequestering of metal ionGO:0051238190.014
spermatid differentiationGO:00485151150.014
primary neural tube formationGO:0014020950.014
regulation of vesicle mediated transportGO:00606271390.014
actin filament organizationGO:00070151130.014
neural tube formationGO:00018411080.014
immune response regulating signaling pathwayGO:00027641250.014
appendage developmentGO:00487361660.013
cellular lipid metabolic processGO:00442553230.013
anatomical structure homeostasisGO:00602491450.013
regulation of ion transmembrane transportGO:00347651190.013
pallium developmentGO:00215431200.013
activation of immune responseGO:00022531380.013
compound eye developmentGO:004874910.013
wound healingGO:00420601570.013
regulation of ion transportGO:00432692150.013
establishment of organelle localizationGO:00516561220.013
positive regulation of protein catabolic processGO:0045732600.013
transmission of nerve impulseGO:0019226760.013
regulation of protein catabolic processGO:00421761080.013
adult behaviorGO:00305341350.013
morphogenesis of a branching structureGO:00017632030.013
endocytosisGO:00068971680.013
spermatid developmentGO:00072861080.013
peptide hormone secretionGO:00300721090.013
response to lipopolysaccharideGO:00324961280.013
regulation of proteolysisGO:00301621640.013
divalent metal ion transportGO:00708381720.013
neural tube closureGO:0001843900.013
positive regulation of growthGO:00459271040.013
regulation of epithelial cell proliferationGO:00506781410.013
gene silencingGO:0016458380.013
Human
organic hydroxy compound transportGO:0015850930.013
metal ion homeostasisGO:00550651890.013
negative regulation of synapse assemblyGO:005196430.013
innate immune responseGO:00450871570.013
central nervous system neuron differentiationGO:00219531620.013
positive regulation of protein kinase activityGO:00458601440.013
nucleocytoplasmic transportGO:00069131390.013
rna processingGO:00063961050.013
regulation of cytoplasmic transportGO:19036491120.013
regulation of cell migrationGO:00303342190.013
protein processingGO:00164851630.013
cellular response to lipopolysaccharideGO:0071222770.013
limbic system developmentGO:0021761720.013
glucose homeostasisGO:00425931280.013
hindbrain developmentGO:00309021280.013
skin developmentGO:00435882200.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.013
response to amino acidGO:0043200370.012
cognitionGO:00508901490.012
actomyosin structure organizationGO:0031032560.012
regulation of sequence specific dna binding transcription factor activityGO:00510901060.012
respiratory tube developmentGO:00303231670.012
response to sterolGO:003631440.012
plasma membrane organizationGO:0007009900.012
b cell activationGO:00421131610.012
actin filament polymerizationGO:0030041440.012
nucleoside monophosphate metabolic processGO:0009123850.012
carbohydrate derivative biosynthetic processGO:19011371830.012
epithelial tube formationGO:00721751300.012
cell divisionGO:00513011200.012
regulation of cell adhesionGO:00301551540.012
lung developmentGO:00303241640.012
carbohydrate homeostasisGO:00335001280.012
positive regulation of neuron projection developmentGO:0010976790.012
hormone secretionGO:00468791280.012
appendage morphogenesisGO:00351071490.012
positive regulation of kinase activityGO:00336741550.012
response to nutrient levelsGO:00316671090.012
reactive nitrogen species metabolic processGO:200105700.012
organelle fissionGO:00482851700.012
purine ribonucleoside monophosphate metabolic processGO:0009167800.012
bone developmentGO:00603481200.012
regulation of leukocyte differentiationGO:19021051590.012
muscle contractionGO:00069361010.012
mrna metabolic processGO:0016071840.012
Human
sequestering of calcium ionGO:0051208180.012
connective tissue developmentGO:00614481790.012
positive regulation of cell projection organizationGO:0031346950.012
smoothened signaling pathwayGO:00072241050.012
regulation of cell cycle processGO:00105641600.012
tissue homeostasisGO:00018941150.012
cell activation involved in immune responseGO:00022631260.012
cellular carbohydrate metabolic processGO:00442621190.012
midgut developmentGO:000749440.012
response to acid chemicalGO:00011011110.012
fat cell differentiationGO:00454441600.012
heart contractionGO:0060047930.012
inflammatory responseGO:00069542440.012
cellular response to acid chemicalGO:0071229680.012
digestive tract developmentGO:00485651900.012
retrograde transport endosome to golgiGO:004214720.012
cytokinetic processGO:003250620.012
epithelial cell proliferationGO:00506731740.012
cellular response to organic cyclic compoundGO:0071407870.012
striated muscle cell developmentGO:00550021250.012
mitotic cytokinesisGO:000028140.011
peptide secretionGO:00027901140.011
cardiac chamber developmentGO:00032051080.011
dorsal ventral axon guidanceGO:003356330.011
membrane tubulationGO:009732040.011
muscle cell developmentGO:00550011330.011
rhythmic processGO:00485111740.011
establishment or maintenance of cytoskeleton polarityGO:003095220.011
organophosphate biosynthetic processGO:00904071220.011
vesicle localizationGO:0051648860.011
rab protein signal transductionGO:003248210.011
regulation of wnt signaling pathwayGO:00301111230.011
negative regulation of protein phosphorylationGO:00019331260.011
negative regulation of organelle organizationGO:0010639900.011
exocytosisGO:00068871210.011
response to extracellular stimulusGO:00099911270.011
monocarboxylic acid metabolic processGO:00327871910.011
photoreceptor cell differentiationGO:0046530520.011
intrinsic apoptotic signaling pathwayGO:00971931320.011
peptide transportGO:00158331330.011
negative regulation of phosphorylationGO:00423261660.011
negative regulation of protein modification processGO:00314001630.011
myeloid leukocyte differentiationGO:00025731190.011
regulation of transmembrane transportGO:00347621280.011
neuron deathGO:00709971540.011
cell recognitionGO:0008037830.011
extracellular structure organizationGO:00430621480.011
embryonic limb morphogenesisGO:00303261260.011
response to inorganic substanceGO:0010035960.011
neuron migrationGO:00017641220.011
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.011
epidermis developmentGO:00085441870.011
immune response activating signal transductionGO:00027571160.011
leukocyte activation involved in immune responseGO:00023661260.011
response to insulinGO:00328681000.011
microtubule based movementGO:0007018840.011
regulation of ossificationGO:00302781120.011
regulation of translationGO:0006417710.011
Human
lipid biosynthetic processGO:00086101790.011
negative regulation of growthGO:0045926990.011
cellular response to amino acid stimulusGO:0071230290.011
response to peptide hormoneGO:00434341270.011
regulation of cell substrate adhesionGO:0010810730.011
negative regulation of apoptotic signaling pathwayGO:20012341040.011
small molecule biosynthetic processGO:00442831320.011
stem cell developmentGO:00488642190.011
cardiocyte differentiationGO:0035051870.011
regulation of protein complex assemblyGO:0043254830.011
cellularizationGO:000734910.011
neuromuscular processGO:0050905990.011
regulation of striated muscle cell differentiationGO:0051153810.011
organic anion transportGO:00157111370.011
bmp signaling pathwayGO:0030509930.011
tube closureGO:0060606910.011
extracellular matrix organizationGO:00301981470.011
regulation of lymphocyte differentiationGO:00456191070.011
calcium ion homeostasisGO:00550741270.011
regulation of response to woundingGO:19030341890.011
establishment of vesicle localizationGO:0051650810.011
palate developmentGO:0060021760.011
regulation of feeding behaviorGO:006025930.011
leukocyte proliferationGO:00706611720.010
developmental cell growthGO:0048588840.010
myeloid cell homeostasisGO:00022621140.010
regulation of rho protein signal transductionGO:0035023710.010
neuron projection guidanceGO:00974851410.010
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.010
lipid transportGO:0006869980.010
anion transportGO:00068201770.010
mesodermal cell migrationGO:000807840.010
cell substrate adhesionGO:00315891300.010
calcium ion transportGO:00068161590.010
localization within membraneGO:005166840.010
cellular response to molecule of bacterial originGO:0071219830.010
regulation of protein serine threonine kinase activityGO:00719001570.010
regulation of cytokine productionGO:00018172660.010
regulation of body fluid levelsGO:00508781620.010
striated muscle contractionGO:0006941450.010
cell growthGO:00160491300.010
oocyte constructionGO:000730820.010
development of primary male sexual characteristicsGO:0046546880.010
regulation of reactive oxygen species metabolic processGO:2000377400.010
immune response regulating cell surface receptor signaling pathwayGO:0002768800.010
nuclear divisionGO:00002801580.010
learning or memoryGO:00076111480.010
ribonucleoside monophosphate metabolic processGO:0009161800.010
response to oxidative stressGO:00069791230.010
cardiac muscle tissue developmentGO:00487381300.010
placenta developmentGO:00018901400.010
cerebellum developmentGO:0021549770.010
response to transforming growth factor betaGO:0071559880.010
positive regulation of cell activationGO:00508671580.010
habituationGO:004695930.010
nucleotide biosynthetic processGO:0009165780.010
reactive oxygen species biosynthetic processGO:190340980.010
divalent inorganic cation homeostasisGO:00725071380.010
single organismal cell cell adhesionGO:00163371310.010
myelinationGO:0042552740.010

Eif2c4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.036
nervous system diseaseDOID:86300.036
central nervous system diseaseDOID:33100.018
organ system cancerDOID:005068600.016
disease of cellular proliferationDOID:1456600.016
cancerDOID:16200.016
musculoskeletal system diseaseDOID:1700.014
immune system diseaseDOID:291400.011
hematopoietic system diseaseDOID:7400.011
sensory system diseaseDOID:005015500.011
connective tissue diseaseDOID:6500.010
eye and adnexa diseaseDOID:149200.010