Mus musculus

170 known processes

Lin28a

lin-28 homolog A (C. elegans)

(Aliases: ENSMUSG00000070700,Lin28,Tex17,AL024421,Lin-28,Gm10299,lin-28A)

Lin28a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
male gamete generationGO:00482322850.398
gene silencing by mirnaGO:0035195100.347
mirna catabolic processGO:001058720.308
meiotic cell cycleGO:00513211220.284
spermatogenesisGO:00072832840.261
macromolecule catabolic processGO:00090572810.193
pre mirna processingGO:003105430.175
regulation of cell cycleGO:00517262810.172
histone modificationGO:00165701590.133
covalent chromatin modificationGO:00165691630.133
gene silencing by rnaGO:0031047190.132
rna 3 end processingGO:0031123200.131
nuclear divisionGO:00002801580.125
rna catabolic processGO:0006401290.124
regulation of cell cycle processGO:00105641600.122
camera type eye developmentGO:00430102660.114
development of primary sexual characteristicsGO:00451371430.108
regulation of cell cycle checkpointGO:190197690.106
cytokine productionGO:00018163190.102
organelle fissionGO:00482851700.098
regulation of cellular ketone metabolic processGO:0010565660.093
posttranscriptional gene silencingGO:0016441100.092
embryonic placenta developmentGO:0001892980.081
heterocycle catabolic processGO:00467002800.075
defense response to other organismGO:00985421970.073
response to organic cyclic compoundGO:00140701980.072
gene silencingGO:0016458380.069
skeletal system developmentGO:00015013560.068
response to organonitrogen compoundGO:00102432460.067
cellular amine metabolic processGO:0044106440.064
placenta developmentGO:00018901400.063
response to molecule of bacterial originGO:00022371430.063
apoptotic signaling pathwayGO:00971903060.062
gonad developmentGO:00084061410.062
regulation of organelle organizationGO:00330432890.061
regulation of neuron differentiationGO:00456642810.060
cell cycle checkpointGO:0000075470.060
meiotic nuclear divisionGO:00071261150.060
positive regulation of growthGO:00459271040.060
cellular nitrogen compound catabolic processGO:00442702800.059
innate immune responseGO:00450871570.059
germ cell developmentGO:00072811850.059
regulation of cytokine productionGO:00018172660.057
cellular macromolecule catabolic processGO:00442652060.054
positive regulation of protein modification processGO:00314012990.052
chromatin organizationGO:00063252060.051
regulation of cellular amino acid metabolic processGO:000652150.050
peptidyl amino acid modificationGO:00181933360.050
negative regulation of cellular component organizationGO:00511291940.048
positive regulation of cell developmentGO:00107202370.048
rna processingGO:00063961050.048
protein homotrimerizationGO:007020740.048
protein dealkylationGO:0008214130.046
regionalizationGO:00030023370.045
muscle tissue developmentGO:00605373080.043
regulation of apoptotic signaling pathwayGO:20012331970.042
neuron deathGO:00709971540.042
skeletal muscle organ developmentGO:00605381630.042
respiratory system developmentGO:00605411900.041
posttranscriptional gene silencing by rnaGO:0035194100.040
protein localization to organelleGO:00333651850.040
production of small rna involved in gene silencing by rnaGO:007091860.039
regulation of bindingGO:00510981110.039
positive regulation of protein phosphorylationGO:00019342420.039
negative regulation of cell proliferationGO:00082852960.039
response to acid chemicalGO:00011011110.038
forebrain developmentGO:00309003020.038
response to lipopolysaccharideGO:00324961280.038
organic cyclic compound catabolic processGO:19013612950.037
sensory organ morphogenesisGO:00905962420.037
telencephalon developmentGO:00215371860.037
defense response to bacteriumGO:00427421190.036
lymphocyte differentiationGO:00300982420.036
regulation of neuron projection developmentGO:00109751690.036
multicellular organism growthGO:00352641610.035
fat cell differentiationGO:00454441600.035
pallium developmentGO:00215431200.034
leukocyte differentiationGO:00025213420.034
immune effector processGO:00022523210.034
histone demethylationGO:0016577130.034
regulation of lymphocyte activationGO:00512492400.034
endocytosisGO:00068971680.034
regulation of cellular component sizeGO:00325351210.034
regulation of cellular amine metabolic processGO:0033238200.034
genitalia developmentGO:0048806370.033
chromatin modificationGO:00165681870.033
axonogenesisGO:00074092740.033
skeletal system morphogenesisGO:00487052030.033
protein oligomerizationGO:0051259670.032
synaptic transmissionGO:00072683290.032
multi multicellular organism processGO:00447061090.032
Worm
cell type specific apoptotic processGO:00972852680.031
mapk cascadeGO:00001652810.031
tumor necrosis factor superfamily cytokine productionGO:0071706510.031
neuron projection guidanceGO:00974851410.031
regulation of neuron apoptotic processGO:00435231220.030
positive regulation of apoptotic processGO:00430652170.030
histone lysine demethylationGO:0070076130.030
gland developmentGO:00487323300.030
small gtpase mediated signal transductionGO:0007264970.030
regulation of cell projection organizationGO:00313442060.030
negative regulation of molecular functionGO:00440922580.030
negative regulation of cytokine productionGO:0001818840.030
regulation of cell motilityGO:20001452360.029
inner ear morphogenesisGO:00424721010.029
chemotaxisGO:00069352470.029
cellular amino acid metabolic processGO:00065201030.029
protein modification by small protein conjugationGO:00324461870.029
negative regulation of cellular amino acid metabolic processGO:004576300.029
amine metabolic processGO:0009308450.029
striated muscle tissue developmentGO:00147062930.029
positive regulation of cell deathGO:00109422240.029
microtubule based processGO:00070172360.029
negative regulation of cellular protein metabolic processGO:00322692470.028
negative regulation of cell developmentGO:00107211690.028
reactive oxygen species metabolic processGO:0072593840.028
development of primary male sexual characteristicsGO:0046546880.028
positive regulation of nervous system developmentGO:00519622210.028
demethylationGO:0070988230.028
ribonucleotide metabolic processGO:00092592910.027
regulation of anatomical structure sizeGO:00900661780.027
dendrite developmentGO:00163581150.027
cell fate commitmentGO:00451652100.027
Worm
negative regulation of cell cycleGO:00457861230.027
intracellular protein transportGO:00068862040.027
spermatid developmentGO:00072861080.027
positive regulation of neuron differentiationGO:00456661410.026
myotube differentiationGO:00149021050.026
mitotic cell cycle processGO:19030471590.026
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555500.026
negative regulation of protein metabolic processGO:00512482820.025
regulation of fat cell differentiationGO:0045598810.025
ossificationGO:00015032160.025
protein demethylationGO:0006482130.025
t cell differentiationGO:00302171740.025
regulation of neuron deathGO:19012141340.025
extracellular structure organizationGO:00430621480.025
rho protein signal transductionGO:0007266320.025
t cell activationGO:00421102890.025
neuron migrationGO:00017641220.024
protein ubiquitinationGO:00165671710.024
cellular chemical homeostasisGO:00550822150.024
female meiotic divisionGO:0007143210.023
central nervous system neuron differentiationGO:00219531620.023
synapse organizationGO:00508081250.023
meiosis iGO:0007127600.023
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.023
protein homooligomerizationGO:0051260430.023
nucleoside triphosphate metabolic processGO:00091412300.023
nucleocytoplasmic transportGO:00069131390.023
tube closureGO:0060606910.023
regulation of cell activationGO:00508652890.023
regulation of protein localizationGO:00328802310.023
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.023
methylationGO:00322591340.023
negative regulation of nervous system developmentGO:00519611560.023
positive regulation of bindingGO:0051099490.023
protein modification by small protein conjugation or removalGO:00706472070.022
organ growthGO:00352651170.022
cell maturationGO:00484691270.022
negative regulation of tumor necrosis factor superfamily cytokine productionGO:1903556170.022
spermatid differentiationGO:00485151150.022
negative regulation of apoptotic signaling pathwayGO:20012341040.022
regulation of endopeptidase activityGO:0052548890.022
organophosphate biosynthetic processGO:00904071220.022
respiratory tube developmentGO:00303231670.022
embryonic organ morphogenesisGO:00485622760.021
membrane organizationGO:00610242450.021
regulation of cell morphogenesis involved in differentiationGO:00107691510.021
defense response to fungusGO:0050832120.021
cell growthGO:00160491300.021
retina development in camera type eyeGO:00600411190.021
asymmetric stem cell divisionGO:009872230.020
bone developmentGO:00603481200.020
cellular homeostasisGO:00197252400.020
cellular lipid metabolic processGO:00442553230.020
regulation of synaptic growth at neuromuscular junctionGO:000858240.020
bmp signaling pathwayGO:0030509930.020
peptidyl tyrosine phosphorylationGO:00181081430.020
cell divisionGO:00513011200.020
connective tissue developmentGO:00614481790.020
reactive oxygen species biosynthetic processGO:190340980.020
positive regulation of programmed cell deathGO:00430682180.020
regulation of reactive oxygen species metabolic processGO:2000377400.020
protein localization to nucleusGO:00345041210.020
heart morphogenesisGO:00030071780.020
lung developmentGO:00303241640.020
cation transmembrane transportGO:00986552660.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.019
nucleoside metabolic processGO:00091162460.019
regulation of proteolysisGO:00301621640.019
limb developmentGO:00601731660.019
protein catabolic processGO:00301632210.019
multicellular organismal agingGO:0010259240.019
response to peptide hormoneGO:00434341270.019
negative regulation of organelle organizationGO:0010639900.019
male gonad developmentGO:0008584880.019
positive regulation of cellular amino acid metabolic processGO:004576430.019
cellular protein catabolic processGO:00442571550.019
regulation of multi organism processGO:00439001110.019
regulation of ion transportGO:00432692150.019
negative regulation of synapse assemblyGO:005196430.018
spindle checkpointGO:0031577120.018
male sex differentiationGO:00466611090.018
synapse assemblyGO:0007416560.018
negative regulation of tumor necrosis factor productionGO:0032720170.018
regulation of mapk cascadeGO:00434082480.018
negative regulation of neuron apoptotic processGO:0043524920.018
cerebral cortex developmentGO:0021987860.018
ribonucleoside catabolic processGO:00424542060.018
neural tube closureGO:0001843900.018
ribonucleoside triphosphate catabolic processGO:00092031990.018
regulation of wnt signaling pathwayGO:00301111230.018
female sex differentiationGO:0046660840.018
ion transmembrane transportGO:00342203610.018
regulation of cell sizeGO:0008361720.018
aromatic compound catabolic processGO:00194392860.018
male meiosisGO:0007140370.018
response to topologically incorrect proteinGO:0035966250.017
regulation of sequence specific dna binding transcription factor activityGO:00510901060.017
cation transportGO:00068123990.017
translationGO:0006412930.017
regulation of response to woundingGO:19030341890.017
carbohydrate metabolic processGO:00059752300.017
muscle cell differentiationGO:00426922610.017
axon guidanceGO:00074111410.017
ribonucleoside triphosphate metabolic processGO:00091992200.017
oxidation reduction processGO:00551143420.017
response to radiationGO:00093141650.017
oogenesisGO:0048477560.017
positive regulation of transferase activityGO:00513471670.017
stem cell maintenanceGO:00198271300.017
hematopoietic progenitor cell differentiationGO:00022441430.017
tube formationGO:00351481400.017
purine ribonucleotide metabolic processGO:00091502900.016
skeletal muscle cell differentiationGO:0035914660.016
regulation of t cell activationGO:00508631700.016
regulation of transferase activityGO:00513382630.016
wnt signaling pathwayGO:00160551880.016
ear morphogenesisGO:00424711180.016
nitrogen compound transportGO:00717052710.016
protein processingGO:00164851630.016
embryonic process involved in female pregnancyGO:006013670.016
cellular ketone metabolic processGO:0042180840.016
regulation of cellular component biogenesisGO:00440871810.016
blastocyst developmentGO:0001824800.016
tumor necrosis factor productionGO:0032640500.016
dna metabolic processGO:00062593030.016
macromolecule methylationGO:00434141200.016
lateral inhibitionGO:004633110.016
microtubule based movementGO:0007018840.016
peptide transportGO:00158331330.016
purine containing compound catabolic processGO:00725232130.016
morphogenesis of embryonic epitheliumGO:00163311590.016
blood vessel morphogenesisGO:00485142850.016
epidermis developmentGO:00085441870.015
extrinsic apoptotic signaling pathwayGO:00971911260.015
neuroblast differentiationGO:001401620.015
regulation of establishment of protein localizationGO:00702011810.015
actin cytoskeleton organizationGO:00300362200.015
response to dsrnaGO:0043331300.015
leukocyte mediated immunityGO:00024431740.015
regulation of protein kinase activityGO:00458592320.015
notch signaling pathwayGO:0007219710.015
asymmetric neuroblast divisionGO:005505910.015
nuclear transportGO:00511691390.015
nucleoside triphosphate catabolic processGO:00091432050.015
myeloid cell differentiationGO:00300992330.015
dsrna fragmentationGO:003105060.015
purine ribonucleoside triphosphate catabolic processGO:00092071990.015
dna methylation involved in gamete generationGO:0043046150.015
cell adhesionGO:00071553290.015
ras protein signal transductionGO:0007265770.015
appendage morphogenesisGO:00351071490.015
positive regulation of glial cell proliferationGO:006025240.015
negative regulation of intracellular signal transductionGO:19025321670.015
morphogenesis of a branching structureGO:00017632030.015
nucleoside phosphate catabolic processGO:19012922220.015
negative regulation of neuron deathGO:1901215980.015
leukocyte proliferationGO:00706611720.015
regulation of nuclear divisionGO:0051783560.015
negative regulation of protein modification processGO:00314001630.015
regulation of intracellular transportGO:00323861590.015
inorganic ion transmembrane transportGO:00986602340.015
nucleotide catabolic processGO:00091662170.015
cellular protein complex assemblyGO:00436231160.014
intrinsic apoptotic signaling pathwayGO:00971931320.014
negative regulation of immune system processGO:00026832090.014
organelle assemblyGO:00709251770.014
cellular ion homeostasisGO:00068731650.014
ncrna processingGO:0034470260.014
regulation of cytoplasmic transportGO:19036491120.014
negative regulation of hormone metabolic processGO:003235140.014
nucleotide metabolic processGO:00091173320.014
negative regulation of cellular amine metabolic processGO:003323910.014
regulation of transmembrane transportGO:00347621280.014
posttranscriptional regulation of gene expressionGO:00106081550.014
developmental cell growthGO:0048588840.014
regulation of reactive oxygen species biosynthetic processGO:190342620.014
neuron apoptotic processGO:00514021420.014
maintenance of locationGO:0051235890.014
regulation of secretion by cellGO:19035302490.014
transmembrane transportGO:00550854120.014
lymphocyte proliferationGO:00466511640.014
dna recombinationGO:0006310920.014
positive regulation of cell activationGO:00508671580.014
protein maturationGO:00516041760.014
extracellular matrix organizationGO:00301981470.014
stem cell proliferationGO:00720891170.014
muscle cell developmentGO:00550011330.013
regulation of chromosome organizationGO:0033044830.013
microtubule cytoskeleton organizationGO:00002261570.013
receptor mediated endocytosisGO:0006898510.013
positive regulation of organ growthGO:0046622290.013
cytoplasmic transportGO:00164822340.013
limb morphogenesisGO:00351081490.013
stem cell developmentGO:00488642190.013
modification dependent protein catabolic processGO:00199411330.013
amide transportGO:00428861380.013
regulation of reproductive processGO:2000241660.013
protein import into nucleusGO:0006606950.013
regulation of defense responseGO:00313472330.013
regulation of translationGO:0006417710.013
regulation of hormone levelsGO:00108172110.013
positive regulation of organelle organizationGO:00106381280.013
ventral spinal cord developmentGO:0021517480.013
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.013
modification dependent macromolecule catabolic processGO:00436321330.013
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.013
homeostasis of number of cellsGO:00488722100.013
glycosyl compound catabolic processGO:19016582060.013
purine ribonucleotide catabolic processGO:00091542080.013
glycosyl compound metabolic processGO:19016572460.013
defense response to gram negative bacteriumGO:0050829280.013
bone morphogenesisGO:0060349780.013
negative regulation of neuron differentiationGO:00456651010.013
proteolysis involved in cellular protein catabolic processGO:00516031470.013
odontogenesis of dentin containing toothGO:0042475660.013
protein importGO:00170381010.013
dna methylationGO:0006306430.013
embryonic limb morphogenesisGO:00303261260.013
inorganic cation transmembrane transportGO:00986622070.013
regulation of organ morphogenesisGO:20000271440.013
protein localization to membraneGO:00726571080.013
regulation of tumor necrosis factor productionGO:0032680490.012
purine ribonucleoside metabolic processGO:00461282410.012
positive regulation of neuron projection developmentGO:0010976790.012
divalent metal ion transportGO:00708381720.012
regulation of lymphocyte differentiationGO:00456191070.012
single organism cell adhesionGO:00986021560.012
compound eye developmentGO:004874910.012
ribose phosphate metabolic processGO:00196932910.012
angiogenesisGO:00015252010.012
regulation of cell cycle phase transitionGO:1901987770.012
organonitrogen compound catabolic processGO:19015652640.012
g protein coupled receptor signaling pathwayGO:00071862430.012
epithelial tube morphogenesisGO:00605623030.012
nucleobase containing small molecule metabolic processGO:00550863520.012
spinal cord developmentGO:0021510810.012
regulation of meiotic cell cycleGO:0051445340.012
cellular response to organonitrogen compoundGO:00714171450.012
meiotic cell cycle processGO:1903046770.012
regulation of myeloid cell differentiationGO:0045637960.012
regulation of cytoskeleton organizationGO:00514931220.012
mirna metabolic processGO:0010586100.012
neural tube formationGO:00018411080.012
establishment of tissue polarityGO:0007164280.012
sensory perceptionGO:00076002450.012
photoreceptor cell developmentGO:0042461400.012
fertilizationGO:00095661270.012
purine nucleoside triphosphate metabolic processGO:00091442260.012
cellular response to dsrnaGO:0071359120.012
regulation of protein targetingGO:1903533610.012
glial cell differentiationGO:00100011310.012
purine nucleotide catabolic processGO:00061952110.012
detection of abiotic stimulusGO:0009582600.012
multicellular organismal signalingGO:0035637910.012
divalent inorganic cation homeostasisGO:00725071380.011
regulation of secretionGO:00510462740.011
phospholipid metabolic processGO:0006644870.011
epithelial cell developmentGO:00020641590.011
gliogenesisGO:00420631410.011
ear developmentGO:00435832000.011
anatomical structure homeostasisGO:00602491450.011
regulation of protein serine threonine kinase activityGO:00719001570.011
cellular response to lipidGO:00713961450.011
somite developmentGO:0061053810.011
negative regulation of protein processingGO:0010955790.011
cell differentiation in spinal cordGO:0021515530.011
metal ion homeostasisGO:00550651890.011
sertoli cell differentiationGO:0060008180.011
symbiosis encompassing mutualism through parasitismGO:0044403830.011
purine ribonucleoside triphosphate metabolic processGO:00092052200.011
protein polymerizationGO:0051258570.011
establishment of protein localization to organelleGO:00725941180.011
positive regulation of neuron projection regenerationGO:007057220.011
tissue homeostasisGO:00018941150.011
actin filament polymerizationGO:0030041440.011
inflammatory responseGO:00069542440.011
positive regulation of cell cycle processGO:0090068610.011
negative regulation of wnt signaling pathwayGO:0030178730.011
developmental growth involved in morphogenesisGO:00605601380.011
limbic system developmentGO:0021761720.011
blastocyst formationGO:0001825330.011
regulation of peptidase activityGO:0052547960.011
purine nucleoside metabolic processGO:00422782410.011
regulation of cellular response to stressGO:00801351590.011
purine containing compound metabolic processGO:00725213110.011
sertoli cell developmentGO:0060009150.011
regulation of ossificationGO:00302781120.011
regulation of actin filament based processGO:0032970990.011
neural tube developmentGO:00219151600.011
alpha beta t cell activationGO:0046631910.011
regenerationGO:0031099380.011
Zebrafish
rhythmic processGO:00485111740.011
cartilage developmentGO:00512161400.011
b cell activationGO:00421131610.011
regulation of cell migrationGO:00303342190.011
forebrain cell migrationGO:0021885580.011
single organism nuclear importGO:1902593950.011
reactive nitrogen species metabolic processGO:200105700.011
primary neural tube formationGO:0014020950.011
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
ribonucleoside metabolic processGO:00091192450.011
single organismal cell cell adhesionGO:00163371310.011
protein trimerizationGO:0070206130.011
carbohydrate derivative catabolic processGO:19011362310.010
nucleoside phosphate metabolic processGO:00067533380.010
regulation of lymphocyte mediated immunityGO:0002706840.010
vagus nerve developmentGO:002156430.010
glucose importGO:0046323320.010
developmental maturationGO:00217001930.010
action potentialGO:0001508780.010
ovulation cycleGO:0042698590.010
mitotic cell cycleGO:00002781950.010
cation homeostasisGO:00550802120.010
organonitrogen compound biosynthetic processGO:19015661920.010
cellular response to hormone stimulusGO:00328701500.010
regulation of hydrolase activityGO:00513362460.010
sensory system developmentGO:004888030.010
photoreceptor cell differentiationGO:0046530520.010
glycerolipid metabolic processGO:00464861220.010
regulation of protein maturationGO:1903317960.010
regulation of cellular catabolic processGO:00313292420.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.010
appendage developmentGO:00487361660.010
regulation of b cell activationGO:0050864810.010
nuclear importGO:0051170950.010
negative regulation of sequence specific dna binding transcription factor activityGO:0043433400.010
positive regulation of cellular amine metabolic processGO:003324050.010
regulation of cell adhesionGO:00301551540.010
alpha amino acid metabolic processGO:1901605590.010
myeloid leukocyte differentiationGO:00025731190.010
regulation of muscle tissue developmentGO:1901861970.010
regulation of cell divisionGO:0051302760.010
embryonic epithelial tube formationGO:00018381300.010

Lin28a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.048
nervous system diseaseDOID:86300.048
sensory system diseaseDOID:005015500.026
eye and adnexa diseaseDOID:149200.014
musculoskeletal system diseaseDOID:1700.011
eye diseaseDOID:561400.011
disease of cellular proliferationDOID:1456600.011
immune system diseaseDOID:291400.011