IMP: Integrative Multi-species Prediction

Mus musculus

465 known processes

Bcl6

B-cell leukemia/lymphoma 6

(Aliases: Bcl5)

Ensembl: ENSMUSG00000022508
Entrez: 12053
UniProtKB: P41183
UniProtKB: Q544F9

Process Predictions
Disease Predictions

Bcl6 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
immune effector process	GO:0002252	321	0.915
adaptive immune response	GO:0002250	155	0.909
lymphocyte differentiation	GO:0030098	242	0.891
b cell activation	GO:0042113	161	0.845
alpha beta t cell differentiation	GO:0046632	69	0.819
germinal center formation	GO:0002467	16	0.789
leukocyte activation involved in immune response	GO:0002366	126	0.769
t cell differentiation	GO:0030217	174	0.764
regulation of cellular amine metabolic process	GO:0033238	20	0.725
regulation of b cell activation	GO:0050864	81	0.703
leukocyte differentiation	GO:0002521	342	0.690
t cell activation	GO:0042110	289	0.684
somatic diversification of immunoglobulins involved in immune response	GO:0002208	36	0.645
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.645
positive regulation of cell death	GO:0010942	224	0.603	Human
b cell activation involved in immune response	GO:0002312	50	0.579
activation of immune response	GO:0002253	138	0.563
dna metabolic process	GO:0006259	303	0.532
interleukin 5 secretion	GO:0072603	2	0.532
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.502
lymphocyte homeostasis	GO:0002260	64	0.494
apoptotic signaling pathway	GO:0097190	306	0.493	Zebrafish
amine metabolic process	GO:0009308	45	0.484
production of molecular mediator of immune response	GO:0002440	103	0.458
b cell mediated immunity	GO:0019724	71	0.453
regulation of lymphocyte activation	GO:0051249	240	0.451
b cell proliferation	GO:0042100	53	0.443
regulation of leukocyte differentiation	GO:1902105	159	0.439
regulation of b cell proliferation	GO:0030888	39	0.433
lymphocyte activation involved in immune response	GO:0002285	93	0.414
myeloid dendritic cell differentiation	GO:0043011	16	0.406
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.405
regulation of cellular amino acid metabolic process	GO:0006521	5	0.383
somatic diversification of immunoglobulins	GO:0016445	43	0.382
interleukin 10 secretion	GO:0072608	4	0.372
skin development	GO:0043588	220	0.372
regulation of lipid transport	GO:0032368	36	0.368
cellular response to biotic stimulus	GO:0071216	92	0.367
t cell activation involved in immune response	GO:0002286	43	0.354
epidermis development	GO:0008544	187	0.349
immunoglobulin mediated immune response	GO:0016064	69	0.346
regulation of leukocyte proliferation	GO:0070663	121	0.346
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.339
b cell differentiation	GO:0030183	78	0.333
regulation of kinase activity	GO:0043549	249	0.333
regulation of zinc ion transport	GO:0071579	2	0.332
lipid localization	GO:0010876	126	0.330
alpha beta t cell activation involved in immune response	GO:0002287	31	0.329
myeloid cell differentiation	GO:0030099	233	0.320
regulation of lymphocyte proliferation	GO:0050670	117	0.317
regulation of establishment of protein localization	GO:0070201	181	0.317
aromatic compound catabolic process	GO:0019439	286	0.313
embryonic placenta development	GO:0001892	98	0.312
immunoglobulin secretion	GO:0048305	17	0.311
alpha beta t cell activation	GO:0046631	91	0.300
leukocyte mediated immunity	GO:0002443	174	0.297
somatic cell dna recombination	GO:0016444	51	0.296
response to peptide	GO:1901652	136	0.294
b cell homeostasis	GO:0001782	34	0.293
negative regulation of zinc ion transport	GO:0071582	2	0.293
mammary gland epithelium development	GO:0061180	65	0.292
t cell differentiation involved in immune response	GO:0002292	30	0.288
protein modification by small protein conjugation or removal	GO:0070647	207	0.288
epithelial cell proliferation	GO:0050673	174	0.285
intracellular protein transport	GO:0006886	204	0.272	Human
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.270
regulation of antimicrobial humoral response	GO:0002759	3	0.269
cytokine production	GO:0001816	319	0.269
cation transport	GO:0006812	399	0.267
response to lipopolysaccharide	GO:0032496	128	0.265
regulation of body fluid levels	GO:0050878	162	0.265
regulation of interleukin 10 biosynthetic process	GO:0045074	1	0.262
response to oxidative stress	GO:0006979	123	0.261
regulation of zinc ion transmembrane transport	GO:0071580	2	0.256
protein import into nucleus	GO:0006606	95	0.255	Human
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.253
isotype switching	GO:0045190	36	0.250
mapk cascade	GO:0000165	281	0.247
regulation of organ growth	GO:0046620	61	0.240
ribonucleoside catabolic process	GO:0042454	206	0.240
positive regulation of production of molecular mediator of immune response	GO:0002702	45	0.239
cellular amino acid metabolic process	GO:0006520	103	0.236
positive regulation of b cell proliferation	GO:0030890	24	0.234
hematopoietic progenitor cell differentiation	GO:0002244	143	0.233
lipid transport	GO:0006869	98	0.231
cellular response to lipid	GO:0071396	145	0.230
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.228
nitrogen compound transport	GO:0071705	271	0.227
multicellular organism growth	GO:0035264	161	0.226
positive regulation of lipid transport	GO:0032370	22	0.225
regulation of protein serine threonine kinase activity	GO:0071900	157	0.224
positive regulation of cell development	GO:0010720	237	0.223
cellular ketone metabolic process	GO:0042180	84	0.220
tissue remodeling	GO:0048771	102	0.215
dna methylation	GO:0006306	43	0.215
negative regulation of zinc ion transmembrane transport	GO:0071583	2	0.214
cell type specific apoptotic process	GO:0097285	268	0.214
t helper cell differentiation	GO:0042093	28	0.213
regulation of protein kinase activity	GO:0045859	232	0.213
lymphocyte proliferation	GO:0046651	164	0.211
response to molecule of bacterial origin	GO:0002237	143	0.209
negative regulation of b cell proliferation	GO:0030889	13	0.208
myeloid dendritic cell activation	GO:0001773	25	0.208
inflammatory response	GO:0006954	244	0.207
odontogenesis	GO:0042476	78	0.207
cellular amine metabolic process	GO:0044106	44	0.206
glycosyl compound catabolic process	GO:1901658	206	0.206
cd4 positive alpha beta t cell activation	GO:0035710	45	0.205
positive regulation of cell activation	GO:0050867	158	0.199
developmental maturation	GO:0021700	193	0.198
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.196
glycerolipid biosynthetic process	GO:0045017	50	0.194
positive regulation of lymphocyte activation	GO:0051251	140	0.193
negative regulation of cellular protein metabolic process	GO:0032269	247	0.192
protein modification by small protein conjugation	GO:0032446	187	0.192
regulation of response to wounding	GO:1903034	189	0.191
regulation of protein targeting	GO:1903533	61	0.191
response to acid chemical	GO:0001101	111	0.190
cytoplasmic transport	GO:0016482	234	0.188	Human
synaptic transmission	GO:0007268	329	0.187
protein localization to organelle	GO:0033365	185	0.183	Human
lipid biosynthetic process	GO:0008610	179	0.183
positive regulation of growth	GO:0045927	104	0.181
cellular response to acid chemical	GO:0071229	68	0.180
carboxylic acid transport	GO:0046942	100	0.180
regulation of myeloid cell differentiation	GO:0045637	96	0.179
regulation of purine nucleotide catabolic process	GO:0033121	122	0.179
cell aging	GO:0007569	35	0.179
cellular metal ion homeostasis	GO:0006875	151	0.178
protein ubiquitination	GO:0016567	171	0.178
leukocyte homeostasis	GO:0001776	79	0.178
positive regulation of cellular amine metabolic process	GO:0033240	5	0.177
regulation of leukocyte mediated immunity	GO:0002703	104	0.175
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.175
regulation of cellular ketone metabolic process	GO:0010565	66	0.170
glycosyl compound metabolic process	GO:1901657	246	0.170
peptidyl serine phosphorylation	GO:0018105	74	0.168
marginal zone b cell differentiation	GO:0002315	2	0.167
defense response to other organism	GO:0098542	197	0.166
extrinsic apoptotic signaling pathway	GO:0097191	126	0.166
positive regulation of protein phosphorylation	GO:0001934	242	0.165
positive regulation of lymphocyte differentiation	GO:0045621	61	0.165
positive regulation of interleukin 12 production	GO:0032735	21	0.163
coagulation	GO:0050817	78	0.163
intracellular receptor signaling pathway	GO:0030522	74	0.163
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.162
nucleoside phosphate metabolic process	GO:0006753	338	0.161
cellular response to organonitrogen compound	GO:0071417	145	0.161
positive regulation of neuron differentiation	GO:0045666	141	0.160
maintenance of location	GO:0051235	89	0.160
regulation of neuron differentiation	GO:0045664	281	0.157
regulation of interleukin 13 secretion	GO:2000665	2	0.157
negative regulation of lymphocyte proliferation	GO:0050672	45	0.156
circadian rhythm	GO:0007623	114	0.156
regulation of membrane potential	GO:0042391	192	0.156
organophosphate catabolic process	GO:0046434	232	0.154
ribonucleotide metabolic process	GO:0009259	291	0.153
regulation of adaptive immune response	GO:0002819	90	0.153
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.151
cell activation involved in immune response	GO:0002263	126	0.151
protein catabolic process	GO:0030163	221	0.151
positive regulation of cellular catabolic process	GO:0031331	148	0.151
positive regulation of hydrolase activity	GO:0051345	148	0.150
regulation of metal ion transport	GO:0010959	106	0.149
negative regulation of protein metabolic process	GO:0051248	282	0.148
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.147
negative regulation of phosphorus metabolic process	GO:0010563	184	0.147
regulation of organ morphogenesis	GO:2000027	144	0.147
organic acid transport	GO:0015849	101	0.146
regulation of lymphocyte mediated immunity	GO:0002706	84	0.146
dna recombination	GO:0006310	92	0.146
somatic diversification of immune receptors via germline recombination within a single locus	GO:0002562	51	0.146
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.146
lymphocyte apoptotic process	GO:0070227	54	0.146
regulation of purine nucleotide metabolic process	GO:1900542	169	0.143
macromolecule methylation	GO:0043414	120	0.143
metal ion homeostasis	GO:0055065	189	0.143
negative regulation of proteolysis	GO:0045861	74	0.142
stem cell differentiation	GO:0048863	268	0.141
carbohydrate metabolic process	GO:0005975	230	0.141
modification dependent protein catabolic process	GO:0019941	133	0.141
glial cell apoptotic process	GO:0034349	3	0.141
cellular response to starvation	GO:0009267	57	0.139
regulation of synapse structural plasticity	GO:0051823	4	0.139
negative regulation of t cell activation	GO:0050868	65	0.139
stem cell development	GO:0048864	219	0.138
negative regulation of protein transport	GO:0051224	46	0.138
regulation of mapk cascade	GO:0043408	248	0.138
monosaccharide metabolic process	GO:0005996	106	0.136
purine ribonucleotide metabolic process	GO:0009150	290	0.135
response to inorganic substance	GO:0010035	96	0.135
ossification	GO:0001503	216	0.134
positive regulation of ras gtpase activity	GO:0032320	65	0.134
response to peptide hormone	GO:0043434	127	0.134
phosphatidylinositol metabolic process	GO:0046488	45	0.133
somatic diversification of immune receptors	GO:0002200	53	0.132
nucleotide metabolic process	GO:0009117	332	0.132
glycerolipid metabolic process	GO:0046486	122	0.131
regulation of interferon gamma production	GO:0032649	57	0.130
negative regulation of cell proliferation	GO:0008285	296	0.129
respiratory system development	GO:0060541	190	0.129
appendage development	GO:0048736	166	0.129
neuron apoptotic process	GO:0051402	142	0.129
cellular response to molecule of bacterial origin	GO:0071219	83	0.129
regulation of alpha beta t cell activation	GO:0046634	53	0.128
regulation of transferase activity	GO:0051338	263	0.128
organ growth	GO:0035265	117	0.128
organic anion transport	GO:0015711	137	0.127
multicellular organismal homeostasis	GO:0048871	164	0.127
phagocytosis	GO:0006909	66	0.127
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.127
cellular response to lipopolysaccharide	GO:0071222	77	0.126
regulation of proteolysis	GO:0030162	164	0.126
regulation of cellular catabolic process	GO:0031329	242	0.126
lipopolysaccharide mediated signaling pathway	GO:0031663	25	0.126
negative regulation of molecular function	GO:0044092	258	0.125
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.125
neuron maturation	GO:0042551	29	0.125
negative regulation of cell activation	GO:0050866	111	0.125
regulation of production of molecular mediator of immune response	GO:0002700	65	0.124
response to organic cyclic compound	GO:0014070	198	0.124
purine nucleotide metabolic process	GO:0006163	302	0.124
regulation of t cell proliferation	GO:0042129	92	0.123
cation homeostasis	GO:0055080	212	0.122
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.122	Zebrafish
regulation of canonical wnt signaling pathway	GO:0060828	82	0.121
positive regulation of gtpase activity	GO:0043547	85	0.120
myeloid leukocyte differentiation	GO:0002573	119	0.120
regulation of immunoglobulin secretion	GO:0051023	12	0.119
mesenchyme development	GO:0060485	152	0.118
macromolecule catabolic process	GO:0009057	281	0.118
t cell proliferation	GO:0042098	120	0.118
positive regulation of kinase activity	GO:0033674	155	0.118
regulation of cell adhesion	GO:0030155	154	0.118
activation of innate immune response	GO:0002218	56	0.117
axonogenesis	GO:0007409	274	0.117
peptidyl serine modification	GO:0018209	83	0.116
calcium ion homeostasis	GO:0055074	127	0.116
inorganic ion transmembrane transport	GO:0098660	234	0.115
negative regulation of protein phosphorylation	GO:0001933	126	0.115
transmembrane transport	GO:0055085	412	0.113
reactive oxygen species metabolic process	GO:0072593	84	0.112
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.112
regulation of immunoglobulin mediated immune response	GO:0002889	37	0.112
purine containing compound metabolic process	GO:0072521	311	0.112
cell fate commitment	GO:0045165	210	0.111
amide transport	GO:0042886	138	0.111
regulation of myotube differentiation	GO:0010830	62	0.111
negative regulation of protein modification process	GO:0031400	163	0.111
positive regulation of myotube differentiation	GO:0010831	24	0.110
homeostasis of number of cells	GO:0048872	210	0.109
fat cell differentiation	GO:0045444	160	0.109
positive regulation of t cell activation	GO:0050870	101	0.109
monocarboxylic acid transport	GO:0015718	44	0.109
ubiquitin dependent protein catabolic process	GO:0006511	129	0.108
humoral immune response	GO:0006959	57	0.108
regulation of inflammatory response	GO:0050727	147	0.108
negative regulation of fibroblast apoptotic process	GO:2000270	6	0.108
leukocyte proliferation	GO:0070661	172	0.108
mesenchymal cell differentiation	GO:0048762	107	0.106
regulation of cellular response to stress	GO:0080135	159	0.106
regulation of cytokine biosynthetic process	GO:0042035	59	0.106
regulation of map kinase activity	GO:0043405	120	0.106
peptidyl amino acid modification	GO:0018193	336	0.105
cellular macromolecule catabolic process	GO:0044265	206	0.105
skeletal system morphogenesis	GO:0048705	203	0.105
nik nf kappab signaling	GO:0038061	14	0.104
ion transmembrane transport	GO:0034220	361	0.104
hexose metabolic process	GO:0019318	98	0.103
positive regulation of secretion	GO:0051047	130	0.102
dna modification	GO:0006304	50	0.102
positive regulation of protein kinase activity	GO:0045860	144	0.102
toll like receptor signaling pathway	GO:0002224	38	0.102
chemotaxis	GO:0006935	247	0.102
regulation of jnk cascade	GO:0046328	62	0.101
nucleoside triphosphate catabolic process	GO:0009143	205	0.101
regulation of apoptotic signaling pathway	GO:2001233	197	0.101	Zebrafish
embryonic appendage morphogenesis	GO:0035113	126	0.100
spleen development	GO:0048536	39	0.099
regulation of synaptic plasticity	GO:0048167	87	0.099
positive regulation of fever generation by positive regulation of prostaglandin secretion	GO:0071812	2	0.099
extracellular matrix organization	GO:0030198	147	0.099
posttranscriptional regulation of gene expression	GO:0010608	155	0.098
multi multicellular organism process	GO:0044706	109	0.098
lipid modification	GO:0030258	65	0.098
regulation of cytokine production	GO:0001817	266	0.098
autophagy	GO:0006914	45	0.097
anion transport	GO:0006820	177	0.097
cellular response to extracellular stimulus	GO:0031668	81	0.097
regulation of neuron death	GO:1901214	134	0.097
tumor necrosis factor mediated signaling pathway	GO:0033209	13	0.097
muscle system process	GO:0003012	141	0.096
morphogenesis of a branching structure	GO:0001763	203	0.096
rhythmic process	GO:0048511	174	0.096
glucose metabolic process	GO:0006006	92	0.095
camera type eye development	GO:0043010	266	0.095	Zebrafish
immunoglobulin production	GO:0002377	73	0.095
skeletal muscle organ development	GO:0060538	163	0.095
regulation of neuron projection development	GO:0010975	169	0.095
immune response activating signal transduction	GO:0002757	116	0.094
regulation of lymphocyte apoptotic process	GO:0070228	41	0.094
peptide transport	GO:0015833	133	0.094
cellular lipid metabolic process	GO:0044255	323	0.093
regulation of peptidase activity	GO:0052547	96	0.093
regulation of interleukin 10 production	GO:0032653	21	0.093
nucleoside metabolic process	GO:0009116	246	0.092
positive regulation of b cell activation	GO:0050871	49	0.092
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.092
positive regulation of protein modification process	GO:0031401	299	0.092
regulation of homeostatic process	GO:0032844	182	0.091
regulation of defense response to bacterium	GO:1900424	3	0.091
erk1 and erk2 cascade	GO:0070371	77	0.089
purine ribonucleoside metabolic process	GO:0046128	241	0.089
negative regulation of intracellular signal transduction	GO:1902532	167	0.089
skeletal system development	GO:0001501	356	0.089
regulation of protein localization	GO:0032880	231	0.089
liver development	GO:0001889	66	0.089
organic cyclic compound catabolic process	GO:1901361	295	0.088
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.088
cognition	GO:0050890	149	0.088
cell adhesion	GO:0007155	329	0.087
cell differentiation involved in embryonic placenta development	GO:0060706	26	0.087
immune response regulating signaling pathway	GO:0002764	125	0.086
gliogenesis	GO:0042063	141	0.086
innate immune response activating signal transduction	GO:0002758	50	0.085
lymphocyte mediated immunity	GO:0002449	139	0.085
fertilization	GO:0009566	127	0.085
purine ribonucleotide catabolic process	GO:0009154	208	0.085
purine nucleoside metabolic process	GO:0042278	241	0.084
forebrain development	GO:0030900	302	0.084
immunoglobulin production involved in immunoglobulin mediated immune response	GO:0002381	43	0.083
canonical wnt signaling pathway	GO:0060070	130	0.083
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.083
organonitrogen compound biosynthetic process	GO:1901566	192	0.083
regulation of cd4 positive alpha beta t cell activation	GO:2000514	24	0.083
dendrite development	GO:0016358	115	0.083
cellular calcium ion homeostasis	GO:0006874	119	0.082
dna alkylation	GO:0006305	43	0.082
regulation of interleukin 5 secretion	GO:2000662	2	0.082
defense response to protozoan	GO:0042832	25	0.079
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.078
ribonucleoside metabolic process	GO:0009119	245	0.078
lipid phosphorylation	GO:0046834	25	0.078
positive regulation of translational initiation	GO:0045948	4	0.078
cellular response to external stimulus	GO:0071496	88	0.077
regulation of secretion by cell	GO:1903530	249	0.077
cellular ion homeostasis	GO:0006873	165	0.077
response to nutrient levels	GO:0031667	109	0.077
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.077
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.077
cation transmembrane transport	GO:0098655	266	0.077
gland development	GO:0048732	330	0.076
nerve development	GO:0021675	67	0.076
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.076
regulation of cell cycle	GO:0051726	281	0.076
regulation of lymphocyte differentiation	GO:0045619	107	0.076
cellular nitrogen compound catabolic process	GO:0044270	280	0.075
regulation of interleukin 10 secretion	GO:2001179	4	0.075
multicellular organismal signaling	GO:0035637	91	0.075
appendage morphogenesis	GO:0035107	149	0.075
response to starvation	GO:0042594	65	0.075
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	1	0.075
muscle contraction	GO:0006936	101	0.074
regulation of ion transmembrane transport	GO:0034765	119	0.074
positive regulation of immune effector process	GO:0002699	107	0.074
cellular chemical homeostasis	GO:0055082	215	0.074
positive regulation of gtp catabolic process	GO:0033126	85	0.074
somatic recombination of immunoglobulin gene segments	GO:0016447	42	0.073
regulation of interleukin 6 production	GO:0032675	55	0.073
covalent chromatin modification	GO:0016569	163	0.073
phosphatidylinositol phosphorylation	GO:0046854	23	0.072
regulation of mitotic cell cycle	GO:0007346	126	0.072
regulation of genetic imprinting	GO:2000653	5	0.072
cellular homeostasis	GO:0019725	240	0.071
membrane organization	GO:0061024	245	0.071
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.071
positive regulation of mapk cascade	GO:0043410	170	0.071
negative regulation of neuron death	GO:1901215	98	0.071
t helper 2 cell cytokine production	GO:0035745	4	0.071
acid secretion	GO:0046717	33	0.071
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.070
cellular amide metabolic process	GO:0043603	58	0.070
phosphatidylinositol 3 phosphate biosynthetic process	GO:0036092	6	0.070
germ cell development	GO:0007281	185	0.070
spermatogenesis	GO:0007283	284	0.069
hemostasis	GO:0007599	78	0.069
hair cycle	GO:0042633	90	0.069
regulation of nucleoside metabolic process	GO:0009118	130	0.069
cellular response to cytokine stimulus	GO:0071345	189	0.069
response to organonitrogen compound	GO:0010243	246	0.069
transmission of nerve impulse	GO:0019226	76	0.068
negative regulation of leukocyte proliferation	GO:0070664	46	0.068
regulation of cytokine secretion involved in immune response	GO:0002739	4	0.068
placenta development	GO:0001890	140	0.068
regulation of hydrolase activity	GO:0051336	246	0.068
muscle cell differentiation	GO:0042692	261	0.067
positive regulation of apoptotic process	GO:0043065	217	0.067	Human
respiratory tube development	GO:0030323	167	0.067
positive regulation of organ growth	GO:0046622	29	0.067
heart morphogenesis	GO:0003007	178	0.067
regulation of autophagy	GO:0010506	30	0.067
cell substrate adhesion	GO:0031589	130	0.067
regulation of nucleotide metabolic process	GO:0006140	169	0.066
cytokine production involved in immune response	GO:0002367	34	0.066
phospholipid metabolic process	GO:0006644	87	0.066
endodermal cell fate specification	GO:0001714	4	0.065
cellular protein catabolic process	GO:0044257	155	0.065
positive regulation of transferase activity	GO:0051347	167	0.065
monosaccharide transport	GO:0015749	58	0.065
synapse maturation	GO:0060074	14	0.064
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.064
regulation of epithelial cell proliferation	GO:0050678	141	0.064
regulation of protein import into nucleus	GO:0042306	52	0.064
regulation of ion transport	GO:0043269	215	0.064
regulation of protein transport	GO:0051223	163	0.064
regulation of striated muscle cell differentiation	GO:0051153	81	0.063
modification dependent macromolecule catabolic process	GO:0043632	133	0.063
cell maturation	GO:0048469	127	0.063
nuclear import	GO:0051170	95	0.063	Human
odontogenesis of dentin containing tooth	GO:0042475	66	0.063
response to hypoxia	GO:0001666	58	0.063
digestive tract development	GO:0048565	190	0.063
regulation of secretion	GO:0051046	274	0.062
muscle tissue development	GO:0060537	308	0.062
heterocycle catabolic process	GO:0046700	280	0.062
organic hydroxy compound metabolic process	GO:1901615	203	0.062
cellular response to nutrient levels	GO:0031669	64	0.062
mesenchymal cell development	GO:0014031	93	0.062
positive regulation of lymphocyte proliferation	GO:0050671	70	0.061
positive regulation of secretion by cell	GO:1903532	114	0.061
positive regulation of leukocyte differentiation	GO:1902107	86	0.061
learning or memory	GO:0007611	148	0.061
cellular response to dna damage stimulus	GO:0006974	207	0.061	Human
purine nucleoside catabolic process	GO:0006152	205	0.061
negative regulation of cellular catabolic process	GO:0031330	47	0.061
regulation of cytokine production involved in immune response	GO:0002718	26	0.061
intrinsic apoptotic signaling pathway	GO:0097193	132	0.060	Zebrafish
organonitrogen compound catabolic process	GO:1901565	264	0.060
neuron death	GO:0070997	154	0.060
action potential	GO:0001508	78	0.060
negative regulation of immune system process	GO:0002683	209	0.060
purine nucleotide catabolic process	GO:0006195	211	0.060
neural tube development	GO:0021915	160	0.060
divalent inorganic cation homeostasis	GO:0072507	138	0.060
nucleotide binding oligomerization domain containing signaling pathway	GO:0070423	6	0.059
digestive system development	GO:0055123	200	0.059
positive regulation of striated muscle cell differentiation	GO:0051155	35	0.058
regulation of dna methylation	GO:0044030	12	0.058
regulation of innate immune response	GO:0045088	91	0.058
negative regulation of protein maturation	GO:1903318	79	0.058
nucleotide catabolic process	GO:0009166	217	0.058
regulation of multi organism process	GO:0043900	111	0.058
regulation of t cell activation	GO:0050863	170	0.058
regulation of protein processing	GO:0070613	96	0.057
regulation of cell activation	GO:0050865	289	0.057
positive regulation of jun kinase activity	GO:0043507	30	0.056
regulation of hormone levels	GO:0010817	211	0.056
regulation of translation	GO:0006417	71	0.056
regulation of antibacterial peptide production	GO:0002786	1	0.056
gonad development	GO:0008406	141	0.056
regulation of transmembrane transport	GO:0034762	128	0.056
positive regulation of map kinase activity	GO:0043406	84	0.056
feeding behavior	GO:0007631	62	0.056
cell division	GO:0051301	120	0.056
regulation of cell migration	GO:0030334	219	0.056
t helper 2 cell differentiation	GO:0045064	12	0.056
nucleoside triphosphate metabolic process	GO:0009141	230	0.055
myeloid leukocyte activation	GO:0002274	83	0.055
engulfment of apoptotic cell	GO:0043652	3	0.055
ribose phosphate metabolic process	GO:0019693	291	0.055
regulation of cell size	GO:0008361	72	0.055
humoral immune response mediated by circulating immunoglobulin	GO:0002455	14	0.055
regulation of intracellular protein transport	GO:0033157	82	0.054
response to reactive oxygen species	GO:0000302	56	0.054
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.054
rho protein signal transduction	GO:0007266	32	0.054
translation	GO:0006412	93	0.054
regulation of anatomical structure size	GO:0090066	178	0.053
regulation of peptide hormone secretion	GO:0090276	75	0.053
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.053
regulation of anion transport	GO:0044070	27	0.053
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.053
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	1	0.053
positive regulation of translation	GO:0045727	19	0.053
extracellular structure organization	GO:0043062	148	0.052
neuron migration	GO:0001764	122	0.052
segmentation	GO:0035282	93	0.052
response to extracellular stimulus	GO:0009991	127	0.052
negative regulation of protein processing	GO:0010955	79	0.052
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.052
bmp signaling pathway	GO:0030509	93	0.052

Bcl6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
immune system disease	DOID:2914	0.116
disease of anatomical entity	DOID:7	0.116
hematopoietic system disease	DOID:74	0.116
primary immunodeficiency disease	DOID:612	0.073
blood protein disease	DOID:620	0.073
agammaglobulinemia	DOID:2583	0.073
common variable immunodeficiency	DOID:12177	0.073
b cell deficiency	DOID:2115	0.073

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