IMP: Integrative Multi-species Prediction

Mus musculus

74 known processes

Sumo2

SMT3 suppressor of mif two 3 homolog 2 (yeast)

(Aliases: Smt3h2,Smt3A,Smt3b,SUMO-2)

Ensembl: ENSMUSG00000020738
Entrez: 170930
UniProtKB: P61957

Process Predictions
Disease Predictions

Sumo2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	43	0.289
rna splicing	GO:0008380	54	0.270
rna splicing via transesterification reactions	GO:0000375	43	0.261
rna interference	GO:0016246	2	0.225
mrna processing	GO:0006397	63	0.199
development of primary sexual characteristics	GO:0045137	143	0.184
cation transmembrane transport	GO:0098655	266	0.166
gene silencing by rna	GO:0031047	19	0.130
mrna splicing via spliceosome	GO:0000398	43	0.109
germ cell development	GO:0007281	185	0.100
inorganic ion transmembrane transport	GO:0098660	234	0.098
posttranscriptional regulation of gene expression	GO:0010608	155	0.085
small gtpase mediated signal transduction	GO:0007264	97	0.080
inorganic cation transmembrane transport	GO:0098662	207	0.079
microtubule cytoskeleton organization	GO:0000226	157	0.078
ion transmembrane transport	GO:0034220	361	0.076
ras protein signal transduction	GO:0007265	77	0.075
nucleotide metabolic process	GO:0009117	332	0.075
negative regulation of molecular function	GO:0044092	258	0.069
cation transport	GO:0006812	399	0.067
regulation of cell cycle	GO:0051726	281	0.064
aromatic compound catabolic process	GO:0019439	286	0.063
transmembrane transport	GO:0055085	412	0.059
cellular response to dna damage stimulus	GO:0006974	207	0.059
chromatin modification	GO:0016568	187	0.059
mrna metabolic process	GO:0016071	84	0.058
regulation of proteolysis	GO:0030162	164	0.058	Mouse
posttranscriptional gene silencing by rna	GO:0035194	10	0.057
regulation of ion transmembrane transport	GO:0034765	119	0.056
organic cyclic compound catabolic process	GO:1901361	295	0.055
nucleobase containing small molecule metabolic process	GO:0055086	352	0.055
regulation of cellular component biogenesis	GO:0044087	181	0.054
cardiac muscle contraction	GO:0060048	32	0.053
regulation of mrna metabolic process	GO:1903311	43	0.052
purine containing compound catabolic process	GO:0072523	213	0.052
meiotic nuclear division	GO:0007126	115	0.049
cell type specific apoptotic process	GO:0097285	268	0.046
cellular nitrogen compound catabolic process	GO:0044270	280	0.046
positive regulation of glycogen catabolic process	GO:0045819	2	0.045
positive regulation of protein phosphorylation	GO:0001934	242	0.043
microtubule based process	GO:0007017	236	0.043
meiotic cell cycle	GO:0051321	122	0.043
spermatogenesis	GO:0007283	284	0.043
positive regulation of cell death	GO:0010942	224	0.043
oocyte construction	GO:0007308	2	0.042
substantia nigra development	GO:0021762	2	0.042
positive regulation of programmed cell death	GO:0043068	218	0.042
regulation of organelle organization	GO:0033043	289	0.042
ribonucleoside catabolic process	GO:0042454	206	0.042
regulation of mitotic cell cycle	GO:0007346	126	0.041
regulation of nucleotide metabolic process	GO:0006140	169	0.040
positive regulation of protein modification process	GO:0031401	299	0.040	Mouse
lung development	GO:0030324	164	0.039
positive regulation of apoptotic process	GO:0043065	217	0.039
rna processing	GO:0006396	105	0.038
gonad development	GO:0008406	141	0.038
oogenesis	GO:0048477	56	0.038
segmentation	GO:0035282	93	0.037
cell division	GO:0051301	120	0.036
regulation of transmembrane transport	GO:0034762	128	0.036
heterocycle catabolic process	GO:0046700	280	0.036
regulation of mrna processing	GO:0050684	41	0.035
regulation of transferase activity	GO:0051338	263	0.035
regulation of mrna splicing via spliceosome	GO:0048024	32	0.035
spermatid development	GO:0007286	108	0.034
amine metabolic process	GO:0009308	45	0.034
organophosphate catabolic process	GO:0046434	232	0.034
protein modification by small protein conjugation or removal	GO:0070647	207	0.034
response to organic cyclic compound	GO:0014070	198	0.034
regulation of lymphocyte activation	GO:0051249	240	0.033
regulation of cellular catabolic process	GO:0031329	242	0.033	Mouse
regulation of binding	GO:0051098	111	0.033
regulation of glycogen catabolic process	GO:0005981	2	0.032
regulation of hydrolase activity	GO:0051336	246	0.032
nucleotide catabolic process	GO:0009166	217	0.031
positive regulation of cellular amine metabolic process	GO:0033240	5	0.031
regulation of ras protein signal transduction	GO:0046578	114	0.031
oocyte axis specification	GO:0007309	2	0.031
positive regulation of organelle organization	GO:0010638	128	0.030
cellular homeostasis	GO:0019725	240	0.030
negative regulation of protein metabolic process	GO:0051248	282	0.030
nucleoside phosphate metabolic process	GO:0006753	338	0.030
negative regulation of mrna processing	GO:0050686	12	0.030
regulation of protein kinase activity	GO:0045859	232	0.029
heart process	GO:0003015	94	0.029
mrna catabolic process	GO:0006402	22	0.029
regulation of cellular amine metabolic process	GO:0033238	20	0.029
regulation of multi organism process	GO:0043900	111	0.029
cellular ketone metabolic process	GO:0042180	84	0.028
regulation of cell activation	GO:0050865	289	0.028
apoptotic signaling pathway	GO:0097190	306	0.028
dna recombination	GO:0006310	92	0.028
ossification	GO:0001503	216	0.027
regulation of kinase activity	GO:0043549	249	0.027
regulation of rna splicing	GO:0043484	37	0.027
negative regulation of rna splicing	GO:0033119	12	0.027
cytoplasmic transport	GO:0016482	234	0.027
divalent inorganic cation transport	GO:0072511	178	0.026
cellular macromolecule catabolic process	GO:0044265	206	0.026	Mouse
regulation of mapk cascade	GO:0043408	248	0.026
purine nucleotide catabolic process	GO:0006195	211	0.026
mitotic cell cycle process	GO:1903047	159	0.026
purine ribonucleoside catabolic process	GO:0046130	205	0.025
leukocyte differentiation	GO:0002521	342	0.025
pole plasm assembly	GO:0007315	2	0.025
muscle system process	GO:0003012	141	0.025
cellular amine metabolic process	GO:0044106	44	0.024
lymphocyte differentiation	GO:0030098	242	0.024
carbohydrate metabolic process	GO:0005975	230	0.024
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.024
epidermis development	GO:0008544	187	0.024
regulation of cell division	GO:0051302	76	0.024
peptidyl amino acid modification	GO:0018193	336	0.024
calcium ion transport	GO:0006816	159	0.024
cell growth	GO:0016049	130	0.024
female gamete generation	GO:0007292	74	0.024
heart contraction	GO:0060047	93	0.023
regulation of nuclear division	GO:0051783	56	0.023
translesion synthesis	GO:0019985	1	0.023
chromatin remodeling	GO:0006338	32	0.023
purine ribonucleoside metabolic process	GO:0046128	241	0.023
purine containing compound metabolic process	GO:0072521	311	0.023
respiratory tube development	GO:0030323	167	0.023
purine ribonucleoside monophosphate catabolic process	GO:0009169	57	0.023
glycosyl compound metabolic process	GO:1901657	246	0.023
regulation of cellular amino acid metabolic process	GO:0006521	5	0.023
striated muscle tissue development	GO:0014706	293	0.022
nucleoside monophosphate catabolic process	GO:0009125	59	0.022
wound healing	GO:0042060	157	0.021
regulation of cellular ketone metabolic process	GO:0010565	66	0.021
purine nucleoside metabolic process	GO:0042278	241	0.021
oocyte anterior posterior axis specification	GO:0007314	2	0.021
dna replication independent nucleosome assembly	GO:0006336	1	0.021
divalent metal ion transport	GO:0070838	172	0.021
stem cell development	GO:0048864	219	0.021
regulation of lymphocyte differentiation	GO:0045619	107	0.021
intracellular receptor signaling pathway	GO:0030522	74	0.021
regulation of cellular response to stress	GO:0080135	159	0.020
regulation of striated muscle cell differentiation	GO:0051153	81	0.020
protein maturation	GO:0051604	176	0.020
body morphogenesis	GO:0010171	45	0.020
mitotic cell cycle	GO:0000278	195	0.020
regulation of reproductive process	GO:2000241	66	0.020
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.019	Mouse
double strand break repair	GO:0006302	48	0.019
ribonucleotide catabolic process	GO:0009261	208	0.019
stem cell differentiation	GO:0048863	268	0.019
male sex differentiation	GO:0046661	109	0.019
regionalization	GO:0003002	337	0.019
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.019
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.019
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.019
carbohydrate derivative catabolic process	GO:1901136	231	0.019
striated muscle contraction	GO:0006941	45	0.019
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.019
organonitrogen compound biosynthetic process	GO:1901566	192	0.018
positive regulation of nucleotide metabolic process	GO:0045981	114	0.018
rna localization	GO:0006403	23	0.018
regulation of ion transmembrane transporter activity	GO:0032412	54	0.018
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.018
protein modification by small protein conjugation	GO:0032446	187	0.018
male gamete generation	GO:0048232	285	0.018
cellular polysaccharide catabolic process	GO:0044247	5	0.018
blood circulation	GO:0008015	195	0.018
mapk cascade	GO:0000165	281	0.018
glycosyl compound catabolic process	GO:1901658	206	0.018
regulation of muscle contraction	GO:0006937	49	0.018
regulation of protein catabolic process	GO:0042176	108	0.018	Mouse
purine nucleoside monophosphate metabolic process	GO:0009126	81	0.018
b cell activation	GO:0042113	161	0.018
regulation of nucleoside metabolic process	GO:0009118	130	0.017
regulation of cell cycle process	GO:0010564	160	0.017
response to radiation	GO:0009314	165	0.017
stem cell maintenance	GO:0019827	130	0.017
response to light stimulus	GO:0009416	135	0.017
purine nucleoside catabolic process	GO:0006152	205	0.017
response to steroid hormone	GO:0048545	56	0.017
purine nucleotide metabolic process	GO:0006163	302	0.017
developmental maturation	GO:0021700	193	0.017
regulation of system process	GO:0044057	200	0.017
cellular response to organic cyclic compound	GO:0071407	87	0.016
positive regulation of cellular catabolic process	GO:0031331	148	0.016	Mouse
organelle localization	GO:0051640	179	0.016
skin development	GO:0043588	220	0.016
atp metabolic process	GO:0046034	75	0.016
response to inorganic substance	GO:0010035	96	0.016
cellular response to cytokine stimulus	GO:0071345	189	0.016
muscle cell differentiation	GO:0042692	261	0.016
positive regulation of hydrolase activity	GO:0051345	148	0.016
regulation of cellular protein catabolic process	GO:1903362	61	0.016	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.016
gene silencing	GO:0016458	38	0.016
regulation of protein complex assembly	GO:0043254	83	0.016
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.015
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.015
skeletal system development	GO:0001501	356	0.015
protein processing	GO:0016485	163	0.015
regulation of ion transport	GO:0043269	215	0.015
ribonucleoside monophosphate catabolic process	GO:0009158	57	0.015
dna repair	GO:0006281	107	0.015
regulation of nucleotide catabolic process	GO:0030811	122	0.015
purine nucleoside monophosphate catabolic process	GO:0009128	58	0.015
positive regulation of transferase activity	GO:0051347	167	0.015
genitalia development	GO:0048806	37	0.015
modification dependent macromolecule catabolic process	GO:0043632	133	0.015	Mouse
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.015
calcium ion transmembrane transport	GO:0070588	85	0.015
regulation of protein processing	GO:0070613	96	0.015
ribose phosphate metabolic process	GO:0019693	291	0.015
regulation of calcium ion transport	GO:0051924	69	0.014
establishment of organelle localization	GO:0051656	122	0.014
response to molecule of bacterial origin	GO:0002237	143	0.014
regulation of erk1 and erk2 cascade	GO:0070372	71	0.014
posttranscriptional gene silencing	GO:0016441	10	0.014
purine ribonucleotide catabolic process	GO:0009154	208	0.014
nucleoside catabolic process	GO:0009164	206	0.014
macromolecule catabolic process	GO:0009057	281	0.014	Mouse
positive regulation of cell cycle	GO:0045787	92	0.014
regulation of blood circulation	GO:1903522	93	0.014
negative regulation of intracellular signal transduction	GO:1902532	167	0.014
organelle fission	GO:0048285	170	0.014
regulation of transporter activity	GO:0032409	57	0.014
regulation of purine nucleotide metabolic process	GO:1900542	169	0.014
cell maturation	GO:0048469	127	0.014
oocyte development	GO:0048599	33	0.014
heart morphogenesis	GO:0003007	178	0.014
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.013
regulation of apoptotic signaling pathway	GO:2001233	197	0.013
regulation of muscle tissue development	GO:1901861	97	0.013
response to oxidative stress	GO:0006979	123	0.013
positive regulation of atpase activity	GO:0032781	3	0.013
regulation of purine nucleotide catabolic process	GO:0033121	122	0.013
cell fate commitment	GO:0045165	210	0.013
positive regulation of calcium ion transport	GO:0051928	27	0.013
negative regulation of cellular component organization	GO:0051129	194	0.013
g protein coupled receptor signaling pathway	GO:0007186	243	0.013
organonitrogen compound catabolic process	GO:1901565	264	0.013
sequestering of metal ion	GO:0051238	19	0.013
negative regulation of cellular protein metabolic process	GO:0032269	247	0.013
ubiquitin dependent protein catabolic process	GO:0006511	129	0.013	Mouse
negative regulation of cell activation	GO:0050866	111	0.013
actin mediated cell contraction	GO:0070252	15	0.013
response to lipopolysaccharide	GO:0032496	128	0.013
purine ribonucleotide metabolic process	GO:0009150	290	0.013
regulation of heart contraction	GO:0008016	77	0.013
regulation of striated muscle contraction	GO:0006942	25	0.013
atp catabolic process	GO:0006200	55	0.013
respiratory system development	GO:0060541	190	0.012
regulation of peptidase activity	GO:0052547	96	0.012
male gonad development	GO:0008584	88	0.012
epithelial cell proliferation	GO:0050673	174	0.012
regulation of cardiac muscle contraction	GO:0055117	21	0.012
lipid localization	GO:0010876	126	0.012
positive regulation of proteolysis	GO:0045862	85	0.012	Mouse
nitrogen compound transport	GO:0071705	271	0.012
fertilization	GO:0009566	127	0.012
positive regulation of neuron differentiation	GO:0045666	141	0.012
telencephalon development	GO:0021537	186	0.012
cellular response to lipid	GO:0071396	145	0.012
cellular protein catabolic process	GO:0044257	155	0.012	Mouse
locomotory behavior	GO:0007626	195	0.012
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.012
cognition	GO:0050890	149	0.012
signal transduction by p53 class mediator	GO:0072331	51	0.012
negative regulation of protein modification process	GO:0031400	163	0.012
cellular lipid metabolic process	GO:0044255	323	0.012
cytokine production	GO:0001816	319	0.012
cellular chemical homeostasis	GO:0055082	215	0.011
regulation of myotube differentiation	GO:0010830	62	0.011
nucleoside metabolic process	GO:0009116	246	0.011
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.011
circulatory system process	GO:0003013	197	0.011
positive regulation of mapk cascade	GO:0043410	170	0.011
single fertilization	GO:0007338	82	0.011
cellular polysaccharide metabolic process	GO:0044264	38	0.011
cellular ion homeostasis	GO:0006873	165	0.011
centrosome organization	GO:0051297	26	0.011
cellular glucan metabolic process	GO:0006073	32	0.011
regulation of body fluid levels	GO:0050878	162	0.011
nucleoside triphosphate metabolic process	GO:0009141	230	0.011
dna metabolic process	GO:0006259	303	0.011
positive regulation of protein kinase activity	GO:0045860	144	0.011
regulation of chromosome organization	GO:0033044	83	0.011
neural nucleus development	GO:0048857	22	0.011
development of primary male sexual characteristics	GO:0046546	88	0.011
nucleoside phosphate catabolic process	GO:1901292	222	0.011
lipid biosynthetic process	GO:0008610	179	0.011
internal protein amino acid acetylation	GO:0006475	42	0.011
translation	GO:0006412	93	0.011
regulation of secretion	GO:0051046	274	0.011
regulation of cytoskeleton organization	GO:0051493	122	0.011
regulation of carbohydrate metabolic process	GO:0006109	75	0.011
regulation of cell cycle phase transition	GO:1901987	77	0.011
regulation of ion homeostasis	GO:2000021	64	0.011
regulation of response to dna damage stimulus	GO:2001020	34	0.010
regulation of neuron death	GO:1901214	134	0.010
nucleocytoplasmic transport	GO:0006913	139	0.010
embryonic organ morphogenesis	GO:0048562	276	0.010
negative regulation of phagocytosis	GO:0050765	4	0.010
muscle tissue development	GO:0060537	308	0.010
internal peptidyl lysine acetylation	GO:0018393	42	0.010
regulation of epithelial cell proliferation	GO:0050678	141	0.010
t cell activation	GO:0042110	289	0.010
adult locomotory behavior	GO:0008344	91	0.010
negative regulation of organelle organization	GO:0010639	90	0.010
sensory perception	GO:0007600	245	0.010
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.010
negative regulation of b cell differentiation	GO:0045578	4	0.010
blood vessel morphogenesis	GO:0048514	285	0.010
thermosensory behavior	GO:0040040	1	0.010
regulation of cell growth	GO:0001558	91	0.010
regulation of metal ion transport	GO:0010959	106	0.010
centrosome cycle	GO:0007098	23	0.010
chromatin organization	GO:0006325	206	0.010

Sumo2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
physical disorder	DOID:0080015	0.017
nervous system disease	DOID:863	0.014
disease of anatomical entity	DOID:7	0.014

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network