IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Spa17

sperm autoantigenic protein 17

(Aliases: Sp17)

Entrez: 20686
Ensembl: ENSMUSG00000001948
UniProtKB: Q545M2
UniProtKB: Q62252

Process Predictions
Disease Predictions

Spa17 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cilium morphogenesis	GO:0060271	102	0.665
cilium assembly	GO:0042384	81	0.538
cellular component assembly involved in morphogenesis	GO:0010927	139	0.198
organelle assembly	GO:0070925	177	0.159
spermatogenesis	GO:0007283	284	0.127
spermatid differentiation	GO:0048515	115	0.085
male gamete generation	GO:0048232	285	0.079
cytoskeleton dependent intracellular transport	GO:0030705	50	0.074
microtubule based movement	GO:0007018	84	0.066
intraciliary transport	GO:0042073	9	0.059
smoothened signaling pathway	GO:0007224	105	0.055
intraciliary retrograde transport	GO:0035721	3	0.052
microtubule based process	GO:0007017	236	0.051
chromatin disassembly	GO:0031498	1	0.050
camera type eye development	GO:0043010	266	0.040
protein maturation	GO:0051604	176	0.037
microtubule based transport	GO:0010970	50	0.035
regionalization	GO:0003002	337	0.032
amine metabolic process	GO:0009308	45	0.032
nucleoside phosphate metabolic process	GO:0006753	338	0.031
purine containing compound metabolic process	GO:0072521	311	0.030
spermatid development	GO:0007286	108	0.029
cilium movement	GO:0003341	28	0.027
cellular amine metabolic process	GO:0044106	44	0.026
sensory organ morphogenesis	GO:0090596	242	0.026
heterocycle catabolic process	GO:0046700	280	0.025
renal system development	GO:0072001	225	0.025
cellular amino acid metabolic process	GO:0006520	103	0.025
apoptotic signaling pathway	GO:0097190	306	0.025
nucleobase containing small molecule metabolic process	GO:0055086	352	0.024
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.024
regulation of cellular amine metabolic process	GO:0033238	20	0.024
limb development	GO:0060173	166	0.024
ribonucleoside catabolic process	GO:0042454	206	0.024
positive regulation of cellular amine metabolic process	GO:0033240	5	0.023
aromatic compound catabolic process	GO:0019439	286	0.023
hematopoietic progenitor cell differentiation	GO:0002244	143	0.023
regulation of cellular amino acid metabolic process	GO:0006521	5	0.022
intracellular protein transport	GO:0006886	204	0.022
axoneme assembly	GO:0035082	15	0.022
photoreceptor cell differentiation	GO:0046530	52	0.021
transmembrane transport	GO:0055085	412	0.021
germ cell development	GO:0007281	185	0.021
cellular nitrogen compound catabolic process	GO:0044270	280	0.021
regulation of cell cycle	GO:0051726	281	0.021
nucleoside phosphate catabolic process	GO:1901292	222	0.020
purine nucleotide catabolic process	GO:0006195	211	0.020
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.020
organophosphate catabolic process	GO:0046434	232	0.019
protein dna complex disassembly	GO:0032986	1	0.019
retina development in camera type eye	GO:0060041	119	0.019
purine nucleotide metabolic process	GO:0006163	302	0.019
ribonucleotide metabolic process	GO:0009259	291	0.019
regulation of binding	GO:0051098	111	0.019
urogenital system development	GO:0001655	261	0.019
organic cyclic compound catabolic process	GO:1901361	295	0.019
glycosyl compound catabolic process	GO:1901658	206	0.019
posttranscriptional regulation of gene expression	GO:0010608	155	0.018
regulation of organelle organization	GO:0033043	289	0.018
determination of left right symmetry	GO:0007368	80	0.018
glycosyl compound metabolic process	GO:1901657	246	0.018
skeletal system development	GO:0001501	356	0.018
nucleotide metabolic process	GO:0009117	332	0.018
ribose phosphate metabolic process	GO:0019693	291	0.017
sensory perception	GO:0007600	245	0.017
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.017
purine nucleoside metabolic process	GO:0042278	241	0.017
muscle tissue development	GO:0060537	308	0.017
homeostasis of number of cells	GO:0048872	210	0.017
regulation of protein localization	GO:0032880	231	0.017
purine ribonucleotide catabolic process	GO:0009154	208	0.017
cellular ketone metabolic process	GO:0042180	84	0.016
nucleoside triphosphate metabolic process	GO:0009141	230	0.016
regulation of cellular ketone metabolic process	GO:0010565	66	0.016
sperm motility	GO:0030317	47	0.016
kidney development	GO:0001822	213	0.016
fat cell differentiation	GO:0045444	160	0.016
nucleotide catabolic process	GO:0009166	217	0.016
embryonic limb morphogenesis	GO:0030326	126	0.016
nucleosome disassembly	GO:0006337	1	0.016
regulation of cell projection organization	GO:0031344	206	0.016
appendage development	GO:0048736	166	0.015
embryonic organ morphogenesis	GO:0048562	276	0.015
negative regulation of phosphate metabolic process	GO:0045936	184	0.015
protein processing	GO:0016485	163	0.015
organonitrogen compound catabolic process	GO:1901565	264	0.015
maintenance of location	GO:0051235	89	0.015
actin cytoskeleton organization	GO:0030036	220	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.015
embryonic appendage morphogenesis	GO:0035113	126	0.015
protein catabolic process	GO:0030163	221	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.014
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.014
cellular response to dna damage stimulus	GO:0006974	207	0.014
carbohydrate derivative catabolic process	GO:1901136	231	0.014
nucleoside catabolic process	GO:0009164	206	0.014
purine containing compound catabolic process	GO:0072523	213	0.014
purine nucleoside catabolic process	GO:0006152	205	0.014
purine ribonucleotide metabolic process	GO:0009150	290	0.014
small gtpase mediated signal transduction	GO:0007264	97	0.014
ribonucleoside metabolic process	GO:0009119	245	0.014
purine ribonucleoside metabolic process	GO:0046128	241	0.014
photoreceptor cell development	GO:0042461	40	0.014
organelle localization	GO:0051640	179	0.014
regulation of membrane potential	GO:0042391	192	0.014
muscle cell differentiation	GO:0042692	261	0.013
negative regulation of protein metabolic process	GO:0051248	282	0.013
nucleoside metabolic process	GO:0009116	246	0.013
dna repair	GO:0006281	107	0.013
negative regulation of cell proliferation	GO:0008285	296	0.013
regulation of cell cycle process	GO:0010564	160	0.013
negative regulation of immune system process	GO:0002683	209	0.013
regulation of apoptotic signaling pathway	GO:2001233	197	0.013
nucleoside triphosphate catabolic process	GO:0009143	205	0.013
epithelial cilium movement	GO:0003351	12	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.013
negative regulation of molecular function	GO:0044092	258	0.013
cation transport	GO:0006812	399	0.013
dna metabolic process	GO:0006259	303	0.013
negative regulation of protein modification process	GO:0031400	163	0.013
inflammatory response	GO:0006954	244	0.013
circulatory system process	GO:0003013	197	0.013
xenobiotic catabolic process	GO:0042178	1	0.013
actin filament based movement	GO:0030048	23	0.013
positive regulation of protein modification process	GO:0031401	299	0.012
regulation of hydrolase activity	GO:0051336	246	0.012
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.012
cellular protein complex assembly	GO:0043623	116	0.012
cell substrate adhesion	GO:0031589	130	0.012
appendage morphogenesis	GO:0035107	149	0.012
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.012
protein localization to organelle	GO:0033365	185	0.012
negative regulation of cellular protein metabolic process	GO:0032269	247	0.012
fertilization	GO:0009566	127	0.012
cellular response to growth factor stimulus	GO:0071363	197	0.012
locomotory behavior	GO:0007626	195	0.012
glutathione metabolic process	GO:0006749	16	0.012
leukocyte migration	GO:0050900	124	0.012
response to oxidative stress	GO:0006979	123	0.012
nucleoside monophosphate metabolic process	GO:0009123	85	0.012
positive regulation of protein phosphorylation	GO:0001934	242	0.012
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.012
negative regulation of phosphorylation	GO:0042326	166	0.012
t cell activation	GO:0042110	289	0.012
blood circulation	GO:0008015	195	0.011
morphogenesis of embryonic epithelium	GO:0016331	159	0.011
positive regulation of binding	GO:0051099	49	0.011
muscle system process	GO:0003012	141	0.011
positive regulation of cell development	GO:0010720	237	0.011
cytoplasmic transport	GO:0016482	234	0.011
establishment of organelle localization	GO:0051656	122	0.011
neural tube development	GO:0021915	160	0.011
carboxylic acid transport	GO:0046942	100	0.011
negative regulation of intracellular signal transduction	GO:1902532	167	0.011
macromolecule catabolic process	GO:0009057	281	0.011
negative regulation of phosphorus metabolic process	GO:0010563	184	0.011
reactive oxygen species metabolic process	GO:0072593	84	0.011
wnt signaling pathway	GO:0016055	188	0.011
cell adhesion	GO:0007155	329	0.011
regulation of nucleotide metabolic process	GO:0006140	169	0.011
meiosis i	GO:0007127	60	0.011
mitochondrion organization	GO:0007005	134	0.011
skin development	GO:0043588	220	0.011
purine ribonucleoside monophosphate metabolic process	GO:0009167	80	0.011
purine ribonucleoside catabolic process	GO:0046130	205	0.011
ribonucleotide catabolic process	GO:0009261	208	0.011
inorganic cation transmembrane transport	GO:0098662	207	0.011
protein targeting	GO:0006605	143	0.011
nuclear division	GO:0000280	158	0.011
response to inorganic substance	GO:0010035	96	0.011
inorganic ion transmembrane transport	GO:0098660	234	0.011
cation transmembrane transport	GO:0098655	266	0.011
eye photoreceptor cell differentiation	GO:0001754	41	0.011
regulation of cellular component biogenesis	GO:0044087	181	0.011
striated muscle tissue development	GO:0014706	293	0.011
muscle contraction	GO:0006936	101	0.011
atp metabolic process	GO:0046034	75	0.011
chromatin organization	GO:0006325	206	0.011
transmission of nerve impulse	GO:0019226	76	0.011
membrane organization	GO:0061024	245	0.011
protein modification by small protein conjugation or removal	GO:0070647	207	0.011
regulation of purine nucleotide metabolic process	GO:1900542	169	0.010
limb morphogenesis	GO:0035108	149	0.010
organelle fission	GO:0048285	170	0.010
digestive tract development	GO:0048565	190	0.010
negative regulation of cell cycle	GO:0045786	123	0.010
ras protein signal transduction	GO:0007265	77	0.010
developmental maturation	GO:0021700	193	0.010
regulation of system process	GO:0044057	200	0.010
regulation of protein processing	GO:0070613	96	0.010
sequestering of calcium ion	GO:0051208	18	0.010
dephosphorylation	GO:0016311	129	0.010
multicellular organismal homeostasis	GO:0048871	164	0.010
male genitalia morphogenesis	GO:0048808	4	0.010
response to organic cyclic compound	GO:0014070	198	0.010
tissue homeostasis	GO:0001894	115	0.010
skeletal muscle organ development	GO:0060538	163	0.010
carbohydrate derivative biosynthetic process	GO:1901137	183	0.010
ventricular system development	GO:0021591	27	0.010
epithelial tube formation	GO:0072175	130	0.010
positive regulation of apoptotic process	GO:0043065	217	0.010
cellular lipid metabolic process	GO:0044255	323	0.010

Spa17 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.031
sensory system disease	DOID:0050155	0.031
disease of anatomical entity	DOID:7	0.031
eye and adnexa disease	DOID:1492	0.031
eye disease	DOID:5614	0.016
retinal disease	DOID:5679	0.013
musculoskeletal system disease	DOID:17	0.013
retinal degeneration	DOID:8466	0.013
bone disease	DOID:0080001	0.012
connective tissue disease	DOID:65	0.012
cardiovascular system disease	DOID:1287	0.011
cancer	DOID:162	0.010
disease of cellular proliferation	DOID:14566	0.010
organ system cancer	DOID:0050686	0.010

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