IMP: Integrative Multi-species Prediction

Mus musculus

30 known processes

Psma1

proteasome (prosome, macropain) subunit, alpha type 1

(Aliases: HC2,C2,alpha-type,Pros-30)

Entrez: 26440
Ensembl: ENSMUSG00000030751
UniProtKB: Q3TS44
UniProtKB: Q9R1P4

Process Predictions
Disease Predictions

Psma1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
modification dependent macromolecule catabolic process	GO:0043632	133	0.991	Yeast
proteasomal ubiquitin independent protein catabolic process	GO:0010499	1	0.988	Yeast
cellular protein catabolic process	GO:0044257	155	0.973	Yeast
cellular macromolecule catabolic process	GO:0044265	206	0.967	Yeast
ubiquitin dependent protein catabolic process	GO:0006511	129	0.947	Yeast
modification dependent protein catabolic process	GO:0019941	133	0.887	Yeast
proteasomal protein catabolic process	GO:0010498	98	0.844	Yeast
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.842	Yeast
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.826	Yeast
cellular response to dna damage stimulus	GO:0006974	207	0.771
protein catabolic process	GO:0030163	221	0.702	Yeast
macromolecule catabolic process	GO:0009057	281	0.646	Yeast
multicellular organismal aging	GO:0010259	24	0.611	Worm
proteasome assembly	GO:0043248	1	0.508
male gamete generation	GO:0048232	285	0.369
microtubule cytoskeleton organization	GO:0000226	157	0.286
spermatid differentiation	GO:0048515	115	0.194
nucleoside triphosphate metabolic process	GO:0009141	230	0.163
oocyte anterior posterior axis specification	GO:0007314	2	0.157
determination of adult lifespan	GO:0008340	11	0.152	Worm
mitotic cell cycle	GO:0000278	195	0.135
positive regulation of dna templated transcription elongation	GO:0032786	2	0.134
engulfment of apoptotic cell	GO:0043652	3	0.121
spermatid development	GO:0007286	108	0.121
oocyte construction	GO:0007308	2	0.110
positive regulation of hydrolase activity	GO:0051345	148	0.104
mitochondrial transport	GO:0006839	36	0.101
microtubule based process	GO:0007017	236	0.098
maternal determination of anterior posterior axis embryo	GO:0008358	2	0.089
organelle fission	GO:0048285	170	0.083
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	23	0.078
spermatogenesis	GO:0007283	284	0.076
cellular nitrogen compound catabolic process	GO:0044270	280	0.075
oocyte axis specification	GO:0007309	2	0.073
germ cell development	GO:0007281	185	0.071
pole plasm assembly	GO:0007315	2	0.069
axonogenesis	GO:0007409	274	0.068
establishment of protein localization to organelle	GO:0072594	118	0.064
dna metabolic process	GO:0006259	303	0.062
regulation of cellular response to stress	GO:0080135	159	0.062
meiotic cell cycle	GO:0051321	122	0.060
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	2	0.057
positive regulation of cellular protein catabolic process	GO:1903364	34	0.056
negative regulation of molecular function	GO:0044092	258	0.055
ribonucleoside metabolic process	GO:0009119	245	0.054
mitochondrion organization	GO:0007005	134	0.053
aromatic compound catabolic process	GO:0019439	286	0.052
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	40	0.051
spindle organization	GO:0007051	28	0.048
organelle assembly	GO:0070925	177	0.048
transmembrane transport	GO:0055085	412	0.047
nucleotide metabolic process	GO:0009117	332	0.046
response to organonitrogen compound	GO:0010243	246	0.045
positive regulation of peptidase activity	GO:0010952	49	0.044
intracellular mrna localization	GO:0008298	4	0.041
guanosine containing compound metabolic process	GO:1901068	144	0.040
regulation of stress activated mapk cascade	GO:0032872	69	0.040
amine metabolic process	GO:0009308	45	0.038
regulation of protein maturation	GO:1903317	96	0.038
cellular protein complex assembly	GO:0043623	116	0.038
positive regulation of proteolysis	GO:0045862	85	0.037
nitrogen compound transport	GO:0071705	271	0.035
gonad development	GO:0008406	141	0.035
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	31	0.035
positive regulation of cell death	GO:0010942	224	0.034
inflammatory response	GO:0006954	244	0.034
protein secretion	GO:0009306	111	0.033
cellular amino acid metabolic process	GO:0006520	103	0.032
regulation of multi organism process	GO:0043900	111	0.032
protein targeting	GO:0006605	143	0.031
protein import	GO:0017038	101	0.031
chromatin modification	GO:0016568	187	0.031
dephosphorylation	GO:0016311	129	0.030
cytoplasmic transport	GO:0016482	234	0.030
response to temperature stimulus	GO:0009266	55	0.029
cellular amine metabolic process	GO:0044106	44	0.029
endocytosis	GO:0006897	168	0.029
negative regulation of immune system process	GO:0002683	209	0.029
forebrain development	GO:0030900	302	0.028
protein localization to mitochondrion	GO:0070585	15	0.028
response to oxidative stress	GO:0006979	123	0.028
purine containing compound metabolic process	GO:0072521	311	0.028
regulation of cellular amino acid metabolic process	GO:0006521	5	0.028
protein refolding	GO:0042026	1	0.027
meiotic cell cycle process	GO:1903046	77	0.027
carbohydrate homeostasis	GO:0033500	128	0.027
mitotic cell cycle process	GO:1903047	159	0.027
maintenance of location	GO:0051235	89	0.026
alcohol metabolic process	GO:0006066	116	0.026
negative regulation of cellular protein metabolic process	GO:0032269	247	0.026
positive regulation of cellular amine metabolic process	GO:0033240	5	0.025
cell maturation	GO:0048469	127	0.025
membrane organization	GO:0061024	245	0.025
protein maturation	GO:0051604	176	0.024
positive regulation of cell development	GO:0010720	237	0.024
regulation of cell cycle	GO:0051726	281	0.024
protein localization to membrane	GO:0072657	108	0.024
apoptotic signaling pathway	GO:0097190	306	0.024
positive regulation of cell cycle	GO:0045787	92	0.023
regulation of binding	GO:0051098	111	0.023
translation	GO:0006412	93	0.023
endomembrane system organization	GO:0010256	147	0.023
mitotic nuclear division	GO:0007067	48	0.023
oogenesis	GO:0048477	56	0.023
camera type eye development	GO:0043010	266	0.022
response to peptide	GO:1901652	136	0.022
cellular lipid metabolic process	GO:0044255	323	0.022
regionalization	GO:0003002	337	0.022
heterocycle catabolic process	GO:0046700	280	0.022
purine nucleotide catabolic process	GO:0006195	211	0.021
stem cell differentiation	GO:0048863	268	0.021
nucleoside metabolic process	GO:0009116	246	0.021
regulation of inflammatory response	GO:0050727	147	0.021
cellular response to oxidative stress	GO:0034599	76	0.021
body morphogenesis	GO:0010171	45	0.020
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.020
protein processing	GO:0016485	163	0.020
female gamete generation	GO:0007292	74	0.020
intracellular protein transport	GO:0006886	204	0.019
posttranscriptional regulation of gene expression	GO:0010608	155	0.019
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.019
nucleoside phosphate metabolic process	GO:0006753	338	0.019
regulation of cellular component biogenesis	GO:0044087	181	0.019
mrna processing	GO:0006397	63	0.019
regulation of proteasomal protein catabolic process	GO:0061136	46	0.019
mapk cascade	GO:0000165	281	0.019
regulation of histone h3 k4 methylation	GO:0051569	12	0.019
cell division	GO:0051301	120	0.018
developmental maturation	GO:0021700	193	0.018
negative regulation of cellular component organization	GO:0051129	194	0.018
positive regulation of protein modification process	GO:0031401	299	0.018
positive regulation of kinase activity	GO:0033674	155	0.018
regulation of cellular amine metabolic process	GO:0033238	20	0.018
telencephalon development	GO:0021537	186	0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.018
synaptic transmission	GO:0007268	329	0.018
stem cell development	GO:0048864	219	0.018
protein localization to organelle	GO:0033365	185	0.018
regulation of translation	GO:0006417	71	0.018
nucleotide catabolic process	GO:0009166	217	0.018
regulation of peptidase activity	GO:0052547	96	0.017
positive regulation of mapk cascade	GO:0043410	170	0.017
double strand break repair	GO:0006302	48	0.017
fertilization	GO:0009566	127	0.017
regulation of kinase activity	GO:0043549	249	0.017
positive regulation of cellular catabolic process	GO:0031331	148	0.017
cellular response to lipid	GO:0071396	145	0.017
stress activated mapk cascade	GO:0051403	80	0.017
regulation of cellular catabolic process	GO:0031329	242	0.017
dna repair	GO:0006281	107	0.016
lymphocyte proliferation	GO:0046651	164	0.016
establishment or maintenance of cell polarity	GO:0007163	86	0.016
leukocyte proliferation	GO:0070661	172	0.016
regulation of transferase activity	GO:0051338	263	0.016
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.016
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.016
response to lipopolysaccharide	GO:0032496	128	0.016
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.016
glucose homeostasis	GO:0042593	128	0.016
mitotic spindle organization	GO:0007052	10	0.015
negative regulation of protein processing	GO:0010955	79	0.015
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.015
protein homotrimerization	GO:0070207	4	0.015
regulation of cellular ketone metabolic process	GO:0010565	66	0.015
lipid localization	GO:0010876	126	0.015
nuclear import	GO:0051170	95	0.015
positive regulation of apoptotic process	GO:0043065	217	0.015
regulation of protein kinase activity	GO:0045859	232	0.015
cellular ketone metabolic process	GO:0042180	84	0.015
regulation of metal ion transport	GO:0010959	106	0.014
positive regulation of growth	GO:0045927	104	0.014
lipid biosynthetic process	GO:0008610	179	0.014
nucleobase containing compound transport	GO:0015931	27	0.014
ribonucleotide catabolic process	GO:0009261	208	0.014
extracellular structure organization	GO:0043062	148	0.014
regulation of reproductive process	GO:2000241	66	0.014
development of primary sexual characteristics	GO:0045137	143	0.014
t cell activation	GO:0042110	289	0.014
dendrite development	GO:0016358	115	0.014
double strand break repair via nonhomologous end joining	GO:0006303	10	0.014
purine ribonucleoside metabolic process	GO:0046128	241	0.014
compound eye development	GO:0048749	1	0.014
protein modification by small protein conjugation or removal	GO:0070647	207	0.014
inorganic cation transmembrane transport	GO:0098662	207	0.014
negative regulation of response to wounding	GO:1903035	77	0.014
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.014
single organism nuclear import	GO:1902593	95	0.014
response to alcohol	GO:0097305	48	0.013
non recombinational repair	GO:0000726	10	0.013
nuclear division	GO:0000280	158	0.013
response to organic cyclic compound	GO:0014070	198	0.013
negative regulation of protein metabolic process	GO:0051248	282	0.013
epithelial to mesenchymal transition	GO:0001837	47	0.013
spindle assembly involved in mitosis	GO:0090307	4	0.013
guanosine containing compound catabolic process	GO:1901069	144	0.013
digestive tract morphogenesis	GO:0048546	147	0.013
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.013
positive regulation of protein catabolic process	GO:0045732	60	0.013
protein deubiquitination	GO:0016579	19	0.013
regulation of endopeptidase activity	GO:0052548	89	0.013
mirna catabolic process	GO:0010587	2	0.013
zymogen activation	GO:0031638	41	0.012
regulation of proteolysis	GO:0030162	164	0.012
nucleoside phosphate catabolic process	GO:1901292	222	0.012
regulation of lymphocyte activation	GO:0051249	240	0.012
sperm individualization	GO:0007291	1	0.012
single fertilization	GO:0007338	82	0.012
regulation of membrane potential	GO:0042391	192	0.012
oocyte differentiation	GO:0009994	35	0.012
glycerolipid biosynthetic process	GO:0045017	50	0.012
cation transport	GO:0006812	399	0.012
molting cycle	GO:0042303	90	0.012	Worm
regulation of jnk cascade	GO:0046328	62	0.012
segmentation	GO:0035282	93	0.012
purine ribonucleotide metabolic process	GO:0009150	290	0.012
organic hydroxy compound metabolic process	GO:1901615	203	0.012
protein localization to chromatin	GO:0071168	3	0.011
adult locomotory behavior	GO:0008344	91	0.011
response to peptide hormone	GO:0043434	127	0.011
nucleus organization	GO:0006997	45	0.011
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.011
multi multicellular organism process	GO:0044706	109	0.011
morphogenesis of embryonic epithelium	GO:0016331	159	0.011
regulation of mapk cascade	GO:0043408	248	0.011
organic cyclic compound catabolic process	GO:1901361	295	0.011
nuclear transport	GO:0051169	139	0.011
organophosphate catabolic process	GO:0046434	232	0.011
rna processing	GO:0006396	105	0.011
er associated ubiquitin dependent protein catabolic process	GO:0030433	10	0.011
exocytosis	GO:0006887	121	0.011
regulation of ion transmembrane transporter activity	GO:0032412	54	0.011
regulation of exit from mitosis	GO:0007096	1	0.011
regulation of hydrolase activity	GO:0051336	246	0.011
stem cell maintenance	GO:0019827	130	0.011
protein autophosphorylation	GO:0046777	61	0.011
ribosomal large subunit assembly	GO:0000027	2	0.011
positive regulation of transcription initiation from rna polymerase ii promoter	GO:0060261	5	0.011
sensory perception	GO:0007600	245	0.011
maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000463	1	0.011
carbohydrate derivative catabolic process	GO:1901136	231	0.011
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.010
regulation of transmembrane transport	GO:0034762	128	0.010
organelle disassembly	GO:1903008	2	0.010
cellular chemical homeostasis	GO:0055082	215	0.010
mitotic cytokinesis	GO:0000281	4	0.010
peptidyl amino acid modification	GO:0018193	336	0.010

Psma1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.044
disease of anatomical entity	DOID:7	0.044
muscular disease	DOID:0080000	0.044
myopathy	DOID:423	0.024
muscle tissue disease	DOID:66	0.024
disease of metabolism	DOID:0014667	0.020
central nervous system disease	DOID:331	0.014
nervous system disease	DOID:863	0.014
neurodegenerative disease	DOID:1289	0.014
inherited metabolic disorder	DOID:655	0.011

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