IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Cyp21a1

cytochrome P450, family 21, subfamily a, polypeptide 1

(Aliases: 21OH,MGC156449,Cyp21a2-ps,Cyp21-ps1,Oh21-1,Cyp21,Cyp21B,Cyp21a2ps,21OHB,21OHA,Oh21-2,21-OH,CYP21OH-A)

Entrez: 13079
Ensembl: ENSMUSG00000024365
UniProtKB: Q3UJ92
UniProtKB: P03940

Process Predictions
Disease Predictions

Cyp21a1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
oxidation reduction process	GO:0055114	342	0.299	Mouse Rat
regulation of inflammatory response	GO:0050727	147	0.255
cytokine mediated signaling pathway	GO:0019221	115	0.202
cellular homeostasis	GO:0019725	240	0.198
positive regulation of blood pressure	GO:0045777	21	0.185
cellular ketone metabolic process	GO:0042180	84	0.183	Rat
apoptotic signaling pathway	GO:0097190	306	0.169	Mouse
gland development	GO:0048732	330	0.139
cellular response to cytokine stimulus	GO:0071345	189	0.128
regulation of body fluid levels	GO:0050878	162	0.120
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.115
cellular ion homeostasis	GO:0006873	165	0.114
cellular lipid metabolic process	GO:0044255	323	0.111	Mouse
regulation of ion transport	GO:0043269	215	0.111
anatomical structure homeostasis	GO:0060249	145	0.100
regulation of blood circulation	GO:1903522	93	0.092
nucleobase containing small molecule metabolic process	GO:0055086	352	0.083
positive regulation of apoptotic process	GO:0043065	217	0.081	Mouse
regulation of secretion	GO:0051046	274	0.078
regulation of cellular amine metabolic process	GO:0033238	20	0.078
maintenance of location	GO:0051235	89	0.078
peptide transport	GO:0015833	133	0.077
cellular amino acid metabolic process	GO:0006520	103	0.075
response to organonitrogen compound	GO:0010243	246	0.074	Rat
tissue homeostasis	GO:0001894	115	0.074
regulation of response to wounding	GO:1903034	189	0.074
organic hydroxy compound metabolic process	GO:1901615	203	0.071	Mouse
membrane organization	GO:0061024	245	0.071
regulation of defense response	GO:0031347	233	0.069
divalent inorganic cation transport	GO:0072511	178	0.066
regulation of metal ion transport	GO:0010959	106	0.063
epithelial tube morphogenesis	GO:0060562	303	0.063
divalent inorganic cation homeostasis	GO:0072507	138	0.063
extrinsic apoptotic signaling pathway	GO:0097191	126	0.062
inflammatory response	GO:0006954	244	0.061
regulation of hormone levels	GO:0010817	211	0.060	Mouse Rat
regulation of homeostatic process	GO:0032844	182	0.059
intracellular protein transport	GO:0006886	204	0.059
fatty acid metabolic process	GO:0006631	121	0.058	Mouse
regulation of cell motility	GO:2000145	236	0.058	Mouse
response to organic cyclic compound	GO:0014070	198	0.056
central nervous system neuron differentiation	GO:0021953	162	0.056
cellular chemical homeostasis	GO:0055082	215	0.055
neuronal action potential	GO:0019228	54	0.055
negative regulation of defense response	GO:0031348	77	0.055
nitrogen compound transport	GO:0071705	271	0.054
regulation of secretion by cell	GO:1903530	249	0.054
peptide secretion	GO:0002790	114	0.053
cellular metal ion homeostasis	GO:0006875	151	0.053
dna metabolic process	GO:0006259	303	0.052
skeletal system development	GO:0001501	356	0.052
regulation of hormone secretion	GO:0046883	88	0.050
organonitrogen compound catabolic process	GO:1901565	264	0.050
circulatory system process	GO:0003013	197	0.050
generation of precursor metabolites and energy	GO:0006091	103	0.049	Mouse
myelination	GO:0042552	74	0.048
reactive oxygen species metabolic process	GO:0072593	84	0.047	Mouse
wnt signaling pathway	GO:0016055	188	0.047
response to lipopolysaccharide	GO:0032496	128	0.047
response to peptide hormone	GO:0043434	127	0.046	Rat
carbohydrate metabolic process	GO:0005975	230	0.046
peptide hormone secretion	GO:0030072	109	0.046
cation homeostasis	GO:0055080	212	0.046
regulation of cellular amino acid metabolic process	GO:0006521	5	0.046
smooth muscle contraction	GO:0006939	44	0.045
transmembrane transport	GO:0055085	412	0.045
cell type specific apoptotic process	GO:0097285	268	0.045
lipid catabolic process	GO:0016042	69	0.044	Mouse
calcium ion homeostasis	GO:0055074	127	0.044
regulation of system process	GO:0044057	200	0.043
pallium development	GO:0021543	120	0.043
heart contraction	GO:0060047	93	0.043
regulation of blood pressure	GO:0008217	93	0.043
cellular calcium ion homeostasis	GO:0006874	119	0.043
hormone secretion	GO:0046879	128	0.043
forebrain development	GO:0030900	302	0.042
reactive oxygen species biosynthetic process	GO:1903409	8	0.042	Mouse
macromolecule catabolic process	GO:0009057	281	0.042
multicellular organismal homeostasis	GO:0048871	164	0.041
regulation of membrane potential	GO:0042391	192	0.041
positive regulation of cellular amine metabolic process	GO:0033240	5	0.041
organic cyclic compound catabolic process	GO:1901361	295	0.041
blood circulation	GO:0008015	195	0.040
action potential	GO:0001508	78	0.040
cellular response to inorganic substance	GO:0071241	37	0.039	Mouse
intermediate filament organization	GO:0045109	15	0.039
angiogenesis	GO:0001525	201	0.039	Mouse
gastrin induced gastric acid secretion	GO:0001698	1	0.039
regulation of vasculature development	GO:1901342	88	0.038	Mouse
nucleotide metabolic process	GO:0009117	332	0.038
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.038
intermediate filament cytoskeleton organization	GO:0045104	26	0.037
regulation of proteolysis	GO:0030162	164	0.037
heart process	GO:0003015	94	0.037
feeding behavior	GO:0007631	62	0.037
positive regulation of cell motility	GO:2000147	116	0.036
regulation of peptide secretion	GO:0002791	77	0.036
nucleotide catabolic process	GO:0009166	217	0.036
vitamin d biosynthetic process	GO:0042368	3	0.035
regulation of glial cell differentiation	GO:0045685	41	0.035
morphogenesis of a branching epithelium	GO:0061138	193	0.035
response to inorganic substance	GO:0010035	96	0.035	Mouse
wound healing	GO:0042060	157	0.034
g protein coupled receptor signaling pathway	GO:0007186	243	0.034
regulation of purine nucleotide metabolic process	GO:1900542	169	0.034
regulation of gliogenesis	GO:0014013	50	0.034
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.034
regulation of hydrolase activity	GO:0051336	246	0.034
regulation of systemic arterial blood pressure	GO:0003073	61	0.033
protein targeting	GO:0006605	143	0.033
positive regulation of secretion by cell	GO:1903532	114	0.033
positive regulation of cytokine production	GO:0001819	174	0.032	Mouse
blood vessel morphogenesis	GO:0048514	285	0.032	Mouse
ribonucleoside metabolic process	GO:0009119	245	0.032
organonitrogen compound biosynthetic process	GO:1901566	192	0.032
nucleoside phosphate catabolic process	GO:1901292	222	0.032
protein localization to organelle	GO:0033365	185	0.031
metal ion homeostasis	GO:0055065	189	0.031
regulation of epithelial cell proliferation	GO:0050678	141	0.031
t cell extravasation	GO:0072683	4	0.031
cellular amine metabolic process	GO:0044106	44	0.030
directional locomotion	GO:0033058	3	0.030
satellite cell activation involved in skeletal muscle regeneration	GO:0014901	3	0.030
neural precursor cell proliferation	GO:0061351	121	0.030
glycosyl compound metabolic process	GO:1901657	246	0.030
positive regulation of programmed cell death	GO:0043068	218	0.030	Mouse
cation transport	GO:0006812	399	0.029
protein catabolic process	GO:0030163	221	0.029
regulation of establishment of protein localization	GO:0070201	181	0.029
response to alkaloid	GO:0043279	34	0.029
lipid biosynthetic process	GO:0008610	179	0.029	Mouse Rat
steroid metabolic process	GO:0008202	119	0.028	Mouse Rat
regulation of map kinase activity	GO:0043405	120	0.028
immune complex clearance	GO:0002434	2	0.028
c21 steroid hormone biosynthetic process	GO:0006700	3	0.028	Rat
regulation of monocyte extravasation	GO:2000437	2	0.028
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.028
positive regulation of cell death	GO:0010942	224	0.028	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.027
protein secretion	GO:0009306	111	0.027
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.027	Mouse
cytosolic calcium ion homeostasis	GO:0051480	70	0.027
sensory perception	GO:0007600	245	0.027
posttranscriptional regulation of gene expression	GO:0010608	155	0.027
rhythmic process	GO:0048511	174	0.027
divalent metal ion transport	GO:0070838	172	0.027
regulation of cell migration	GO:0030334	219	0.027	Mouse
energy derivation by oxidation of organic compounds	GO:0015980	77	0.027	Mouse
regulation of angiogenesis	GO:0045765	81	0.026	Mouse
nuclear import	GO:0051170	95	0.026
protein maturation	GO:0051604	176	0.026
fat cell differentiation	GO:0045444	160	0.026
glycoprotein metabolic process	GO:0009100	116	0.025
positive regulation of homeostatic process	GO:0032846	64	0.025
g protein coupled receptor internalization	GO:0002031	3	0.025
regulation of protein kinase activity	GO:0045859	232	0.025
tissue remodeling	GO:0048771	102	0.025
single organism nuclear import	GO:1902593	95	0.025
adult behavior	GO:0030534	135	0.025
sulfur compound metabolic process	GO:0006790	100	0.025
negative regulation of protein metabolic process	GO:0051248	282	0.025
muscle system process	GO:0003012	141	0.025
monocarboxylic acid metabolic process	GO:0032787	191	0.025	Mouse
glial cell differentiation	GO:0010001	131	0.024
hexose transport	GO:0008645	56	0.024
fat soluble vitamin biosynthetic process	GO:0042362	4	0.024
nucleoside metabolic process	GO:0009116	246	0.024
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	GO:2000526	1	0.024
positive regulation of cell development	GO:0010720	237	0.024
methylation	GO:0032259	134	0.024
cellular response to organonitrogen compound	GO:0071417	145	0.024	Rat
organic hydroxy compound transport	GO:0015850	93	0.024
immune effector process	GO:0002252	321	0.023
positive regulation of hormone secretion	GO:0046887	38	0.023
protein import into nucleus	GO:0006606	95	0.023
oligodendrocyte differentiation	GO:0048709	53	0.023
transmission of nerve impulse	GO:0019226	76	0.023
positive regulation of glycolytic process	GO:0045821	4	0.023
myeloid leukocyte differentiation	GO:0002573	119	0.023
circadian rhythm	GO:0007623	114	0.023
cellular response to lipid	GO:0071396	145	0.023
compound eye development	GO:0048749	1	0.023
purine ribonucleoside metabolic process	GO:0046128	241	0.022
organelle localization	GO:0051640	179	0.022
purine nucleotide catabolic process	GO:0006195	211	0.022
immune complex clearance by monocytes and macrophages	GO:0002436	2	0.022
ribonucleoside catabolic process	GO:0042454	206	0.022
protein localization to nucleus	GO:0034504	121	0.022
nucleoside catabolic process	GO:0009164	206	0.022
negative regulation of phosphate metabolic process	GO:0045936	184	0.021
leukocyte migration	GO:0050900	124	0.021
inorganic cation transmembrane transport	GO:0098662	207	0.021
muscle contraction	GO:0006936	101	0.021
cellular response to acid chemical	GO:0071229	68	0.021
amine metabolic process	GO:0009308	45	0.021	Mouse
negative regulation of eosinophil degranulation	GO:0043310	1	0.021
fucosylation	GO:0036065	9	0.021
carbohydrate derivative biosynthetic process	GO:1901137	183	0.021
epithelial cell proliferation	GO:0050673	174	0.021
neuron apoptotic process	GO:0051402	142	0.021
hormone metabolic process	GO:0042445	86	0.021	Mouse Rat
purine containing compound catabolic process	GO:0072523	213	0.021
microglial cell activation	GO:0001774	3	0.021
t helper 17 cell chemotaxis	GO:0035705	1	0.021
regulation of peptide hormone secretion	GO:0090276	75	0.021
sodium ion homeostasis	GO:0055078	7	0.020
progesterone metabolic process	GO:0042448	4	0.020	Rat
glycosyl compound catabolic process	GO:1901658	206	0.020
mitochondrion organization	GO:0007005	134	0.020
cellular response to cadmium ion	GO:0071276	3	0.020	Mouse
regulation of systemic arterial blood pressure mediated by a chemical signal	GO:0003044	33	0.020
multicellular organism growth	GO:0035264	161	0.020
telencephalon development	GO:0021537	186	0.020
glucose metabolic process	GO:0006006	92	0.020
regulation of immunological synapse formation	GO:2000520	2	0.020
cytokine production	GO:0001816	319	0.020	Mouse
glucose transport	GO:0015758	56	0.020
endocrine system development	GO:0035270	98	0.020
ribose phosphate metabolic process	GO:0019693	291	0.020
negative regulation of interleukin 5 secretion	GO:2000663	1	0.020
small molecule biosynthetic process	GO:0044283	132	0.019
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.019
positive regulation of protein phosphorylation	GO:0001934	242	0.019
purine nucleotide metabolic process	GO:0006163	302	0.019
glucose import	GO:0046323	32	0.019
phasic smooth muscle contraction	GO:0014821	8	0.019
hematopoietic stem cell migration	GO:0035701	1	0.019
neutral lipid metabolic process	GO:0006638	57	0.019
negative regulation of epithelial cell proliferation	GO:0050680	64	0.018
aromatic compound catabolic process	GO:0019439	286	0.018
cofactor metabolic process	GO:0051186	80	0.018	Mouse
regulation of cellular catabolic process	GO:0031329	242	0.018
cellular carbohydrate metabolic process	GO:0044262	119	0.018
peptidyl amino acid modification	GO:0018193	336	0.018
establishment of protein localization to organelle	GO:0072594	118	0.018
positive regulation of cell migration	GO:0030335	109	0.018
regulation of feeding behavior	GO:0060259	3	0.018
neuron migration	GO:0001764	122	0.018
response to molecule of bacterial origin	GO:0002237	143	0.018
monosaccharide transport	GO:0015749	58	0.018
leukocyte activation involved in immune response	GO:0002366	126	0.018
cytoplasmic transport	GO:0016482	234	0.018
positive regulation of cell activation	GO:0050867	158	0.018
macromolecule methylation	GO:0043414	120	0.018
regulation of anatomical structure size	GO:0090066	178	0.018
homeostasis of number of cells	GO:0048872	210	0.018
positive regulation of protein modification process	GO:0031401	299	0.018
purine containing compound metabolic process	GO:0072521	311	0.017
positive regulation of monocyte extravasation	GO:2000439	1	0.017
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.017
insulin secretion	GO:0030073	89	0.017
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.017
positive regulation of t cell receptor signaling pathway	GO:0050862	4	0.017
response to nutrient levels	GO:0031667	109	0.017
response to metal ion	GO:0010038	47	0.017	Mouse
regulation of synaptic plasticity	GO:0048167	87	0.017
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.017
epithelial cell development	GO:0002064	159	0.017
purine ribonucleoside catabolic process	GO:0046130	205	0.017
regulation of lymphocyte activation	GO:0051249	240	0.017
operant conditioning	GO:0035106	2	0.017
heterocycle catabolic process	GO:0046700	280	0.017
circadian regulation of gene expression	GO:0032922	48	0.017
morphogenesis of a branching structure	GO:0001763	203	0.017
purine nucleotide biosynthetic process	GO:0006164	65	0.017
mapk cascade	GO:0000165	281	0.017
organic hydroxy compound biosynthetic process	GO:1901617	77	0.016
muscle tissue development	GO:0060537	308	0.016
cellular alcohol metabolic process	GO:0044107	3	0.016
vascular process in circulatory system	GO:0003018	62	0.016
negative regulation of cellular protein metabolic process	GO:0032269	247	0.016
negative regulation of muscle contraction	GO:0045932	12	0.016
response to bile acid	GO:1903412	1	0.016
protein modification by small protein conjugation or removal	GO:0070647	207	0.016
long chain fatty acid metabolic process	GO:0001676	26	0.016	Mouse
response to insulin	GO:0032868	100	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.016
positive regulation of dendritic cell chemotaxis	GO:2000510	1	0.016
cellular response to temperature stimulus	GO:0071502	2	0.016
regulation of hematopoietic stem cell migration	GO:2000471	1	0.016
negative regulation of secretion	GO:0051048	61	0.016
amide transport	GO:0042886	138	0.016
activation of immune response	GO:0002253	138	0.015
dephosphorylation	GO:0016311	129	0.015
regulation of cytokine production	GO:0001817	266	0.015	Mouse
regulation of satellite cell activation involved in skeletal muscle regeneration	GO:0014717	3	0.015
interspecies interaction between organisms	GO:0044419	83	0.015
tissue migration	GO:0090130	68	0.015	Mouse
positive regulation of peptide hormone secretion	GO:0090277	31	0.015
nucleoside phosphate metabolic process	GO:0006753	338	0.015
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.015
purine nucleoside metabolic process	GO:0042278	241	0.015
response to oxygen levels	GO:0070482	62	0.015
negative regulation of inflammatory response	GO:0050728	61	0.015
negative regulation of vasculature development	GO:1901343	26	0.015
regulation of tissue remodeling	GO:0034103	38	0.015
locomotory behavior	GO:0007626	195	0.015
intermediate filament based process	GO:0045103	27	0.015
glial cell development	GO:0021782	54	0.015
positive regulation of protein catabolic process	GO:0045732	60	0.015
negative regulation of cell proliferation	GO:0008285	296	0.015	Mouse
negative regulation of nervous system development	GO:0051961	156	0.015
sequestering of metal ion	GO:0051238	19	0.014
regulation of interleukin 5 secretion	GO:2000662	2	0.014
somatostatin signaling pathway	GO:0038170	2	0.014
regulation of cellular ketone metabolic process	GO:0010565	66	0.014
sensory perception of pain	GO:0019233	47	0.014
lipid transport	GO:0006869	98	0.014
molting cycle	GO:0042303	90	0.014
regulation of protein secretion	GO:0050708	82	0.014
negative regulation of response to wounding	GO:1903035	77	0.014
forebrain neuron differentiation	GO:0021879	52	0.014
positive regulation of hydrolase activity	GO:0051345	148	0.014
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	4	0.014
digestive system development	GO:0055123	200	0.014
regulation of lymphocyte mediated immunity	GO:0002706	84	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.014
purine ribonucleotide metabolic process	GO:0009150	290	0.013
regulation of ion homeostasis	GO:2000021	64	0.013
ameboidal type cell migration	GO:0001667	128	0.013	Mouse
protein import	GO:0017038	101	0.013
regulation of heart contraction	GO:0008016	77	0.013
intrinsic apoptotic signaling pathway	GO:0097193	132	0.013	Mouse
regulation of blood vessel size	GO:0050880	56	0.013
cyclic purine nucleotide metabolic process	GO:0052652	43	0.013
epithelial cell morphogenesis	GO:0003382	41	0.013
endomembrane system organization	GO:0010256	147	0.013
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.013
mitral valve development	GO:0003174	4	0.013
regulation of protein catabolic process	GO:0042176	108	0.013
bone remodeling	GO:0046849	53	0.013
leukocyte differentiation	GO:0002521	342	0.013
multi organism behavior	GO:0051705	62	0.013
cell cell recognition	GO:0009988	44	0.013
positive regulation of chemotaxis	GO:0050921	38	0.013
positive regulation of t cell extravasation	GO:2000409	2	0.013
positive regulation of gliogenesis	GO:0014015	27	0.013
ribonucleotide metabolic process	GO:0009259	291	0.013
organophosphate biosynthetic process	GO:0090407	122	0.013
cerebral cortex development	GO:0021987	86	0.013
vascular endothelial growth factor production	GO:0010573	13	0.013	Mouse
regulation of cellular component biogenesis	GO:0044087	181	0.013
lipid localization	GO:0010876	126	0.013
steroid biosynthetic process	GO:0006694	47	0.013	Mouse Rat
intracellular receptor signaling pathway	GO:0030522	74	0.013
pigment metabolic process	GO:0042440	32	0.013
renal system process	GO:0003014	48	0.013
positive regulation of proteolysis	GO:0045862	85	0.013
response to phenylpropanoid	GO:0080184	22	0.013
sequestering of calcium ion	GO:0051208	18	0.013
regulation of innate immune response	GO:0045088	91	0.013
regulation of urea metabolic process	GO:0034255	1	0.013
vasodilation	GO:0042311	28	0.013
positive regulation of vasoconstriction	GO:0045907	4	0.013
regulation of kinase activity	GO:0043549	249	0.013
vasodilation by norepinephrine epinephrine involved in regulation of systemic arterial blood pressure	GO:0002025	3	0.013
regulation of renal sodium excretion	GO:0035813	3	0.013
regulation of ion transmembrane transport	GO:0034765	119	0.013
response to tumor necrosis factor	GO:0034612	26	0.012
regulation of lipid transport	GO:0032368	36	0.012
keratinocyte migration	GO:0051546	3	0.012
purine ribonucleotide catabolic process	GO:0009154	208	0.012
epithelial cell migration	GO:0010631	63	0.012	Mouse
engulfment of apoptotic cell	GO:0043652	3	0.012
regulation of nucleotide metabolic process	GO:0006140	169	0.012
bone resorption	GO:0045453	38	0.012
response to alcohol	GO:0097305	48	0.012
myeloid cell differentiation	GO:0030099	233	0.012
positive regulation of lipid transport	GO:0032370	22	0.012
regulation of glutamate metabolic process	GO:2000211	1	0.012
regulation of peptide transport	GO:0090087	91	0.012
ion transmembrane transport	GO:0034220	361	0.012
regulation of renin secretion into blood stream	GO:1900133	4	0.012
transition metal ion transport	GO:0000041	38	0.012
striated muscle tissue development	GO:0014706	293	0.012
calcium ion transport	GO:0006816	159	0.012
carbohydrate transport	GO:0008643	62	0.012
regulation of tube size	GO:0035150	57	0.012
nucleocytoplasmic transport	GO:0006913	139	0.012
b cell activation	GO:0042113	161	0.012
interleukin 13 secretion	GO:0072611	2	0.012
acid secretion	GO:0046717	33	0.012
phenol containing compound metabolic process	GO:0018958	60	0.012
negative regulation of phosphorus metabolic process	GO:0010563	184	0.012
negative regulation of immune system process	GO:0002683	209	0.012
positive regulation of immunological synapse formation	GO:2000522	1	0.012
histamine induced gastric acid secretion	GO:0001697	1	0.012
epithelium migration	GO:0090132	63	0.012	Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.012
glycoprotein biosynthetic process	GO:0009101	89	0.012
regulation of interleukin 13 secretion	GO:2000665	2	0.012
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.012
cellular nitrogen compound catabolic process	GO:0044270	280	0.012
response to oxidative stress	GO:0006979	123	0.012	Mouse
purine nucleoside catabolic process	GO:0006152	205	0.012
regulation of organ morphogenesis	GO:2000027	144	0.012
regulation of protein localization	GO:0032880	231	0.012
positive regulation of mapk cascade	GO:0043410	170	0.012
habituation	GO:0046959	3	0.012
regulation of neuron differentiation	GO:0045664	281	0.012
carbohydrate derivative catabolic process	GO:1901136	231	0.012
chromatin organization	GO:0006325	206	0.012
cell activation involved in immune response	GO:0002263	126	0.011
regulation of transmembrane transport	GO:0034762	128	0.011
neurotransmitter transport	GO:0006836	76	0.011
protein processing	GO:0016485	163	0.011
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	3	0.011
covalent chromatin modification	GO:0016569	163	0.011
multi multicellular organism process	GO:0044706	109	0.011
nucleoside triphosphate catabolic process	GO:0009143	205	0.011
eosinophil mediated immunity	GO:0002447	1	0.011
digestion	GO:0007586	40	0.011
response to peptide	GO:1901652	136	0.011	Rat
cytokine metabolic process	GO:0042107	71	0.011
regulation of neurological system process	GO:0031644	22	0.011
regulation of cell activation	GO:0050865	289	0.011
corticotropin releasing hormone secretion	GO:0043396	2	0.011
lymphocyte activation involved in immune response	GO:0002285	93	0.011
membrane fusion	GO:0061025	38	0.011
regulation of acute inflammatory response	GO:0002673	27	0.011
kidney development	GO:0001822	213	0.011
negative regulation of angiogenesis	GO:0016525	25	0.011
forebrain cell migration	GO:0021885	58	0.011
negative regulation of homeostatic process	GO:0032845	71	0.011
calcitriol biosynthetic process from calciol	GO:0036378	3	0.011
glycosylation	GO:0070085	62	0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.011
nucleoside triphosphate metabolic process	GO:0009141	230	0.011
carbohydrate biosynthetic process	GO:0016051	74	0.011
male gamete generation	GO:0048232	285	0.011
activation of mapk activity	GO:0000187	59	0.011
renal sodium excretion	GO:0035812	3	0.011
glycogen metabolic process	GO:0005977	32	0.010
protein methylation	GO:0006479	81	0.010
maintenance of protein location in nucleus	GO:0051457	2	0.010
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.010
hair follicle morphogenesis	GO:0031069	29	0.010
glucocorticoid metabolic process	GO:0008211	9	0.010	Mouse
ribonucleotide catabolic process	GO:0009261	208	0.010
regulation of systemic arterial blood pressure by hormone	GO:0001990	25	0.010
histone modification	GO:0016570	159	0.010
rna processing	GO:0006396	105	0.010

Cyp21a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.053
inherited metabolic disorder	DOID:655	0.053
disease of anatomical entity	DOID:7	0.020
nervous system disease	DOID:863	0.020
lipid metabolism disorder	DOID:3146	0.016
cancer	DOID:162	0.013
disease of cellular proliferation	DOID:14566	0.013

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