IMP: Integrative Multi-species Prediction

Mus musculus

48 known processes

Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

(Aliases: AA409156,1110067B02Rik,mKIAA1479,Sema6D-2,Sema6D-1,Sema6D-6,Sema6D-5,Sema6D-4,D330011G23)

Entrez: 214968
Ensembl: ENSMUSG00000027200
UniProtKB: Q76KF0
UniProtKB: A2AW73

Process Predictions
Disease Predictions

Sema6d biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
neuron projection extension	GO:1990138	64	0.884	Mouse
t cell activation	GO:0042110	289	0.744	Mouse
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.715
transmembrane transport	GO:0055085	412	0.626
inflammatory response	GO:0006954	244	0.599
regulation of ras gtpase activity	GO:0032318	88	0.594	Mouse
sympathetic neuron projection guidance	GO:0097491	4	0.569	Mouse
cellular metal ion homeostasis	GO:0006875	151	0.561
branchiomotor neuron axon guidance	GO:0021785	7	0.549	Mouse
stem cell differentiation	GO:0048863	268	0.544	Mouse
nucleotide catabolic process	GO:0009166	217	0.519	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.517
ion transmembrane transport	GO:0034220	361	0.501
blood circulation	GO:0008015	195	0.501	Mouse
small gtpase mediated signal transduction	GO:0007264	97	0.500
g protein coupled receptor signaling pathway	GO:0007186	243	0.494
ras protein signal transduction	GO:0007265	77	0.466
regulation of nucleotide metabolic process	GO:0006140	169	0.464	Mouse
axonogenesis	GO:0007409	274	0.447	Mouse Fly
leukocyte migration	GO:0050900	124	0.437
regulation of cell migration	GO:0030334	219	0.436
myeloid cell differentiation	GO:0030099	233	0.435
trunk neural crest cell migration	GO:0036484	4	0.410	Mouse
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation	GO:2000721	2	0.404
cation transport	GO:0006812	399	0.400
regulation of system process	GO:0044057	200	0.397	Mouse
cation homeostasis	GO:0055080	212	0.392
cerebellar granule cell precursor tangential migration	GO:0021935	1	0.387
trigeminal nerve morphogenesis	GO:0021636	6	0.382	Mouse
leukocyte activation involved in immune response	GO:0002366	126	0.382	Mouse
glycoprotein metabolic process	GO:0009100	116	0.378
heart contraction	GO:0060047	93	0.374	Mouse
negative regulation of cellular amine metabolic process	GO:0033239	1	0.366
semaphorin plexin signaling pathway involved in bone trabecula morphogenesis	GO:1900220	2	0.357	Mouse
neuron projection guidance	GO:0097485	141	0.355	Mouse Fly
regulation of blood circulation	GO:1903522	93	0.352	Mouse
sympathetic neuron projection extension	GO:0097490	4	0.351	Mouse
cell adhesion	GO:0007155	329	0.350
negative regulation of phosphate metabolic process	GO:0045936	184	0.348	Mouse
branching morphogenesis of an epithelial tube	GO:0048754	159	0.344
negative regulation of protein metabolic process	GO:0051248	282	0.339	Mouse
developmental cell growth	GO:0048588	84	0.330	Mouse
purine containing compound metabolic process	GO:0072521	311	0.327	Mouse
negative regulation of cellular component organization	GO:0051129	194	0.324	Mouse
negative regulation of peptidyl serine phosphorylation	GO:0033137	10	0.321
apoptotic signaling pathway	GO:0097190	306	0.318
smooth muscle cell migration	GO:0014909	10	0.312
gliogenesis	GO:0042063	141	0.310
positive regulation of cell development	GO:0010720	237	0.306	Mouse
purine nucleotide metabolic process	GO:0006163	302	0.299	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.298
gtp catabolic process	GO:0006184	143	0.298	Mouse
regulation of cell cycle	GO:0051726	281	0.294
ribose phosphate metabolic process	GO:0019693	291	0.293	Mouse
microglia development	GO:0014005	2	0.292
positive regulation of cell migration	GO:0030335	109	0.291
regulation of membrane potential	GO:0042391	192	0.290
lymphocyte activation involved in immune response	GO:0002285	93	0.289	Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.286	Mouse
negative regulation of cell growth	GO:0030308	44	0.283	Mouse
positive regulation of cell motility	GO:2000147	116	0.283
mapk cascade	GO:0000165	281	0.277
semaphorin plexin signaling pathway involved in neuron projection guidance	GO:1902285	6	0.277	Mouse
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.276	Mouse
t cell differentiation	GO:0030217	174	0.275	Mouse
positive regulation of purine nucleotide catabolic process	GO:0033123	88	0.269	Mouse
homeostasis of number of cells	GO:0048872	210	0.268
nucleoside phosphate metabolic process	GO:0006753	338	0.267	Mouse
fat cell differentiation	GO:0045444	160	0.266
cell growth	GO:0016049	130	0.262	Mouse
regulation of axon guidance	GO:1902667	13	0.260	Mouse Fly
negative regulation of ras protein signal transduction	GO:0046580	18	0.259
regulation of ion transport	GO:0043269	215	0.259
action potential	GO:0001508	78	0.255
lymphocyte differentiation	GO:0030098	242	0.255	Mouse
positive regulation of neuron differentiation	GO:0045666	141	0.253	Mouse
angiogenesis	GO:0001525	201	0.250	Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.249
leukocyte differentiation	GO:0002521	342	0.248	Mouse
negative regulation of axon guidance	GO:1902668	8	0.248	Mouse
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.246	Mouse
heterocycle catabolic process	GO:0046700	280	0.245	Mouse
regulation of rho protein signal transduction	GO:0035023	71	0.242	Mouse
purine ribonucleotide metabolic process	GO:0009150	290	0.236	Mouse
epithelial tube morphogenesis	GO:0060562	303	0.236	Mouse
transmission of nerve impulse	GO:0019226	76	0.230
ribonucleoside metabolic process	GO:0009119	245	0.229	Mouse
cytokine mediated signaling pathway	GO:0019221	115	0.227
extrinsic apoptotic signaling pathway	GO:0097191	126	0.225
purine ribonucleotide catabolic process	GO:0009154	208	0.225	Mouse
regulation of cell activation	GO:0050865	289	0.225
regulation of cell motility	GO:2000145	236	0.224
semaphorin plexin signaling pathway involved in axon guidance	GO:1902287	6	0.222	Mouse
granulocyte migration	GO:0097530	43	0.222
neuron migration	GO:0001764	122	0.217	Mouse
cellular homeostasis	GO:0019725	240	0.217
cellular calcium ion homeostasis	GO:0006874	119	0.215
guanosine containing compound catabolic process	GO:1901069	144	0.214	Mouse
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.213
organonitrogen compound catabolic process	GO:1901565	264	0.212	Mouse
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway	GO:0051482	4	0.211
positive regulation of gtp catabolic process	GO:0033126	85	0.211	Mouse
peptidyl amino acid modification	GO:0018193	336	0.210	Mouse
regulation of map kinase activity	GO:0043405	120	0.210
positive regulation of nucleoside metabolic process	GO:0045979	91	0.207	Mouse
positive regulation of behavior	GO:0048520	40	0.207
purine nucleoside catabolic process	GO:0006152	205	0.202	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.202
glycoprotein biosynthetic process	GO:0009101	89	0.199
regulation of erk1 and erk2 cascade	GO:0070372	71	0.198
cellular response to cytokine stimulus	GO:0071345	189	0.198
positive regulation of ras gtpase activity	GO:0032320	65	0.198	Mouse
positive regulation of nervous system development	GO:0051962	221	0.197	Mouse
actin cytoskeleton organization	GO:0030036	220	0.196
nucleoside catabolic process	GO:0009164	206	0.194	Mouse
immune effector process	GO:0002252	321	0.194	Mouse
rho protein signal transduction	GO:0007266	32	0.194
regulation of cell size	GO:0008361	72	0.194	Mouse Fly
positive regulation of nucleotide metabolic process	GO:0045981	114	0.192	Mouse
cellular ketone metabolic process	GO:0042180	84	0.191
positive regulation of lymphocyte activation	GO:0051251	140	0.188
rhythmic process	GO:0048511	174	0.188
regulation of inflammatory response	GO:0050727	147	0.186
purine containing compound catabolic process	GO:0072523	213	0.186	Mouse
positive regulation of t cell activation	GO:0050870	101	0.185
cytokine production	GO:0001816	319	0.184
leukocyte homeostasis	GO:0001776	79	0.184
cerebral cortex cell migration	GO:0021795	44	0.183	Mouse
regulation of neuron differentiation	GO:0045664	281	0.181	Mouse Fly
inorganic ion transmembrane transport	GO:0098660	234	0.181
positive regulation of cellular catabolic process	GO:0031331	148	0.180	Mouse
blood vessel morphogenesis	GO:0048514	285	0.179	Mouse
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.179	Mouse
regulation of ion transmembrane transport	GO:0034765	119	0.178
gonadotrophin releasing hormone neuronal migration to the hypothalamus	GO:0021828	3	0.177	Mouse
gtp metabolic process	GO:0046039	144	0.175	Mouse
eye photoreceptor cell differentiation	GO:0001754	41	0.174
purine ribonucleoside metabolic process	GO:0046128	241	0.173	Mouse
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.169
blood coagulation	GO:0007596	76	0.166
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.165
positive regulation of mapk cascade	GO:0043410	170	0.165
epithelial cell migration	GO:0010631	63	0.164	Mouse
neutrophil chemotaxis	GO:0030593	36	0.164
positive regulation of cell activation	GO:0050867	158	0.164
regulation of ras protein signal transduction	GO:0046578	114	0.163	Mouse
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.162
organophosphate catabolic process	GO:0046434	232	0.161	Mouse
peptidyl tyrosine phosphorylation	GO:0018108	143	0.161	Mouse
positive regulation of map kinase activity	GO:0043406	84	0.159
negative regulation of phosphorus metabolic process	GO:0010563	184	0.157	Mouse
metal ion homeostasis	GO:0055065	189	0.156
neural crest cell migration involved in autonomic nervous system development	GO:1901166	5	0.156	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.154
t cell migration	GO:0072678	19	0.154
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.154	Mouse
telencephalon development	GO:0021537	186	0.153	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.153
regulation of cellular component size	GO:0032535	121	0.152	Mouse Fly
positive regulation of chemotaxis	GO:0050921	38	0.152
regulation of extent of cell growth	GO:0061387	52	0.152	Mouse
regulation of purine nucleotide catabolic process	GO:0033121	122	0.151	Mouse
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.150
t cell activation involved in immune response	GO:0002286	43	0.150	Mouse
morphogenesis of a branching structure	GO:0001763	203	0.149	Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.148
regulation of mapk cascade	GO:0043408	248	0.148
ameboidal type cell migration	GO:0001667	128	0.147	Mouse
myeloid leukocyte migration	GO:0097529	57	0.147
anion transport	GO:0006820	177	0.147
positive regulation of protein modification process	GO:0031401	299	0.147	Mouse
neuronal action potential	GO:0019228	54	0.145
axon guidance	GO:0007411	141	0.145	Mouse Fly
regulation of muscle system process	GO:0090257	80	0.145
positive regulation of ion transport	GO:0043270	65	0.144
learning or memory	GO:0007611	148	0.144
immune response activating signal transduction	GO:0002757	116	0.144
glial cell differentiation	GO:0010001	131	0.143
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.143	Mouse Fly
anatomical structure homeostasis	GO:0060249	145	0.142
cell activation involved in immune response	GO:0002263	126	0.142	Mouse
locomotory behavior	GO:0007626	195	0.141	Fly
regulation of chemotaxis	GO:0050920	53	0.141	Mouse Fly
cellular extravasation	GO:0045123	17	0.140
protein kinase b signaling	GO:0043491	74	0.137
cerebral cortex tangential migration using cell axon interactions	GO:0021824	3	0.136	Mouse
alpha beta t cell activation	GO:0046631	91	0.136	Mouse
response to organonitrogen compound	GO:0010243	246	0.136
purine nucleoside metabolic process	GO:0042278	241	0.136	Mouse
regulation of body fluid levels	GO:0050878	162	0.136
nucleotide metabolic process	GO:0009117	332	0.135	Mouse
purine nucleotide catabolic process	GO:0006195	211	0.135	Mouse
monocyte extravasation	GO:0035696	2	0.134
glycosyl compound catabolic process	GO:1901658	206	0.134	Mouse
sequestering of calcium ion	GO:0051208	18	0.133
regulation of angiogenesis	GO:0045765	81	0.133	Mouse
granulocyte chemotaxis	GO:0071621	39	0.132
positive regulation of leukocyte proliferation	GO:0070665	73	0.132
ventral trunk neural crest cell migration	GO:0036486	4	0.132	Mouse
negative regulation of phosphorylation	GO:0042326	166	0.131	Mouse
erk1 and erk2 cascade	GO:0070371	77	0.131
positive regulation of cellular amine metabolic process	GO:0033240	5	0.131
divalent metal ion transport	GO:0070838	172	0.130
cell chemotaxis	GO:0060326	81	0.129
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.129
axon extension involved in axon guidance	GO:0048846	14	0.128	Mouse
regulation of gtp catabolic process	GO:0033124	113	0.128	Mouse
regulation of response to wounding	GO:1903034	189	0.128
regulation of protein serine threonine kinase activity	GO:0071900	157	0.127
peptidyl tyrosine modification	GO:0018212	145	0.127	Mouse
wnt signaling pathway	GO:0016055	188	0.127
pallium development	GO:0021543	120	0.125	Mouse
divalent inorganic cation transport	GO:0072511	178	0.124
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.124
regulation of muscle contraction	GO:0006937	49	0.124
regulation of anatomical structure size	GO:0090066	178	0.123	Mouse Fly
leukocyte chemotaxis	GO:0030595	69	0.123
regulation of vasculature development	GO:1901342	88	0.122	Mouse
multicellular organismal homeostasis	GO:0048871	164	0.122
negative regulation of growth	GO:0045926	99	0.120	Mouse
brown fat cell differentiation	GO:0050873	36	0.120
cd4 positive alpha beta t cell activation	GO:0035710	45	0.119	Mouse
regulation of metal ion transport	GO:0010959	106	0.119
positive regulation of kinase activity	GO:0033674	155	0.119
immune response regulating signaling pathway	GO:0002764	125	0.118
myeloid cell homeostasis	GO:0002262	114	0.118
facial nerve structural organization	GO:0021612	10	0.117	Mouse
regulation of ion homeostasis	GO:2000021	64	0.117
gland development	GO:0048732	330	0.117	Mouse
regulation of transmembrane transport	GO:0034762	128	0.117
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.117	Mouse
microglia differentiation	GO:0014004	2	0.117
regulation of cytokine production	GO:0001817	266	0.117
embryonic placenta development	GO:0001892	98	0.115
antigen receptor mediated signaling pathway	GO:0050851	64	0.115
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.115
regulation of purine nucleotide metabolic process	GO:1900542	169	0.115	Mouse
telencephalon cell migration	GO:0022029	55	0.114	Mouse
regulation of homeostatic process	GO:0032844	182	0.113
calcium ion homeostasis	GO:0055074	127	0.113
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.113
relaxation of vascular smooth muscle	GO:0060087	7	0.113
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.111
membrane organization	GO:0061024	245	0.111
glial cell development	GO:0021782	54	0.110
regulation of axon extension	GO:0030516	43	0.110	Mouse
regulation of osteoblast proliferation	GO:0033688	15	0.110
amino acid transport	GO:0006865	61	0.109
extracellular structure organization	GO:0043062	148	0.109
exocrine system development	GO:0035272	45	0.109	Mouse
synaptic transmission	GO:0007268	329	0.109
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.109	Mouse
facioacoustic ganglion development	GO:1903375	3	0.108	Mouse
cell matrix adhesion	GO:0007160	68	0.107
regulation of t cell differentiation	GO:0045580	83	0.105
divalent inorganic cation homeostasis	GO:0072507	138	0.105
negative regulation of neuron death	GO:1901215	98	0.104
regulation of phospholipase c activity	GO:1900274	3	0.104
cell division	GO:0051301	120	0.104
regulation of t cell activation	GO:0050863	170	0.103
maintenance of location	GO:0051235	89	0.103
defense response to other organism	GO:0098542	197	0.102
tissue homeostasis	GO:0001894	115	0.102
organonitrogen compound biosynthetic process	GO:1901566	192	0.102
memory	GO:0007613	58	0.102
regulation of smooth muscle cell migration	GO:0014910	6	0.101
regulation of organelle organization	GO:0033043	289	0.100
motor neuron axon guidance	GO:0008045	26	0.100	Mouse Fly
regulation of monocyte extravasation	GO:2000437	2	0.099
positive regulation of gtpase activity	GO:0043547	85	0.098	Mouse
purine nucleotide biosynthetic process	GO:0006164	65	0.098
cellular amine metabolic process	GO:0044106	44	0.098
negative regulation of synaptic vesicle transport	GO:1902804	3	0.096
fibroblast proliferation	GO:0048144	35	0.096
nucleobase containing small molecule metabolic process	GO:0055086	352	0.096	Mouse
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	26	0.096
positive regulation of organelle organization	GO:0010638	128	0.095
positive regulation of smooth muscle cell migration	GO:0014911	4	0.094
response to light stimulus	GO:0009416	135	0.093
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.093
muscle contraction	GO:0006936	101	0.093
blood vessel remodeling	GO:0001974	33	0.093
cellular response to growth factor stimulus	GO:0071363	197	0.093
regulation of protein kinase activity	GO:0045859	232	0.093
neutrophil migration	GO:1990266	37	0.093
morphogenesis of a branching epithelium	GO:0061138	193	0.092	Mouse
chemotaxis	GO:0006935	247	0.092	Mouse Fly
organic acid transport	GO:0015849	101	0.092
regulation of nucleoside metabolic process	GO:0009118	130	0.092	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.091
response to lipopolysaccharide	GO:0032496	128	0.090
positive regulation of homeostatic process	GO:0032846	64	0.090
sensory perception	GO:0007600	245	0.089
sphingolipid metabolic process	GO:0006665	45	0.089
osteoclast differentiation	GO:0030316	62	0.089
response to peptide hormone	GO:0043434	127	0.089
neuron apoptotic process	GO:0051402	142	0.089
regulation of leukocyte differentiation	GO:1902105	159	0.088
cation transmembrane transport	GO:0098655	266	0.087
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.087
amine metabolic process	GO:0009308	45	0.086
digestive tract development	GO:0048565	190	0.086
regulation of stress activated mapk cascade	GO:0032872	69	0.086
activation of mapk activity	GO:0000187	59	0.085
forebrain cell migration	GO:0021885	58	0.085	Mouse
sodium ion transport	GO:0006814	73	0.084
regulation of heart contraction	GO:0008016	77	0.084	Mouse
glycerolipid metabolic process	GO:0046486	122	0.084
glycerophospholipid metabolic process	GO:0006650	71	0.083
photoreceptor cell development	GO:0042461	40	0.083
macrophage differentiation	GO:0030225	20	0.082
muscle cell differentiation	GO:0042692	261	0.082	Mouse
regulation of cytoskeleton organization	GO:0051493	122	0.082
neural tube formation	GO:0001841	108	0.082	Mouse
regulation of cell projection organization	GO:0031344	206	0.082	Mouse Fly
negative regulation of cellular protein metabolic process	GO:0032269	247	0.081	Mouse
regulation of alpha beta t cell activation	GO:0046634	53	0.081
cell migration involved in vasculogenesis	GO:0035441	2	0.081
positive regulation of phospholipase c activity	GO:0010863	2	0.081
hemostasis	GO:0007599	78	0.081
heart process	GO:0003015	94	0.080	Mouse
second messenger mediated signaling	GO:0019932	73	0.080
positive regulation of leukocyte differentiation	GO:1902107	86	0.080
vascular endothelial growth factor receptor signaling pathway	GO:0048010	24	0.080
platelet activation	GO:0030168	40	0.080
negative regulation of neuron apoptotic process	GO:0043524	92	0.079
actin filament organization	GO:0007015	113	0.079
positive regulation of metanephric mesenchymal cell migration	GO:2000591	1	0.078
cellular response to organonitrogen compound	GO:0071417	145	0.078
salivary gland development	GO:0007431	37	0.078	Mouse
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.078	Mouse
negative regulation of protein phosphorylation	GO:0001933	126	0.077	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.077
wound healing	GO:0042060	157	0.076
adaptive immune response	GO:0002250	155	0.076	Mouse
g protein coupled acetylcholine receptor signaling pathway	GO:0007213	4	0.076
ribonucleotide catabolic process	GO:0009261	208	0.075	Mouse
smooth muscle cell chemotaxis	GO:0071670	2	0.075
anatomical structure arrangement	GO:0048532	20	0.075	Mouse
regulation of protein kinase b signaling	GO:0051896	56	0.074
positive regulation of calcium ion transport	GO:0051928	27	0.074
positive regulation of endothelial cell proliferation	GO:0001938	17	0.073
negative regulation of insulin receptor signaling pathway	GO:0046627	14	0.073
reactive oxygen species metabolic process	GO:0072593	84	0.073
regulation of fibroblast proliferation	GO:0048145	34	0.072
eye photoreceptor cell development	GO:0042462	31	0.072
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway	GO:0035793	1	0.072
substrate dependent cell migration	GO:0006929	18	0.072	Mouse
neuromuscular process	GO:0050905	99	0.072	Fly
b cell activation	GO:0042113	161	0.071
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.071
signal transduction in absence of ligand	GO:0038034	55	0.071
cellular ion homeostasis	GO:0006873	165	0.071
plasma membrane organization	GO:0007009	90	0.070
nucleoside triphosphate catabolic process	GO:0009143	205	0.070	Mouse
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.070
positive regulation of protein kinase b signaling	GO:0051897	32	0.070
regulation of rho gtpase activity	GO:0032319	58	0.069	Mouse
positive regulation of sodium ion transport	GO:0010765	13	0.069
positive regulation of ion transmembrane transport	GO:0034767	24	0.069
myofibril assembly	GO:0030239	34	0.069
germ cell development	GO:0007281	185	0.069
acute inflammatory response	GO:0002526	41	0.069
lymphocyte proliferation	GO:0046651	164	0.069
inorganic cation transmembrane transport	GO:0098662	207	0.069
mesenchymal cell differentiation	GO:0048762	107	0.068	Mouse
hypothalamus gonadotrophin releasing hormone neuron development	GO:0021888	4	0.067	Mouse
nitrogen compound transport	GO:0071705	271	0.067
establishment of neuroblast polarity	GO:0045200	1	0.067
negative regulation of immune system process	GO:0002683	209	0.067
intracellular protein transport	GO:0006886	204	0.067
retina development in camera type eye	GO:0060041	119	0.067
regulation of neuron death	GO:1901214	134	0.067
central nervous system neuron differentiation	GO:0021953	162	0.066	Mouse
regulation of cardiac muscle contraction	GO:0055117	21	0.066
t cell receptor signaling pathway	GO:0050852	46	0.066
cellular response to peptide	GO:1901653	92	0.065
positive regulation of fibroblast proliferation	GO:0048146	20	0.065
protein autophosphorylation	GO:0046777	61	0.065
response to organic cyclic compound	GO:0014070	198	0.065
limbic system development	GO:0021761	72	0.065	Mouse
stem cell proliferation	GO:0072089	117	0.065
mucopolysaccharide metabolic process	GO:1903510	25	0.064
defense response to virus	GO:0051607	68	0.064
positive regulation of epithelial cell proliferation	GO:0050679	68	0.064
myelination	GO:0042552	74	0.064
regulation of adaptive immune response	GO:0002819	90	0.063
cytoplasmic transport	GO:0016482	234	0.063
positive regulation of nucleotide catabolic process	GO:0030813	88	0.063	Mouse
lymphocyte migration	GO:0072676	26	0.063
visual learning	GO:0008542	44	0.062
heart morphogenesis	GO:0003007	178	0.062
cognition	GO:0050890	149	0.062
metanephric mesenchymal cell migration	GO:0035789	2	0.062
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.062
development of primary sexual characteristics	GO:0045137	143	0.062	Mouse Worm
chemorepulsion of branchiomotor axon	GO:0021793	1	0.061
amino acid transmembrane transport	GO:0003333	37	0.061
negative regulation of protein modification process	GO:0031400	163	0.061	Mouse
carboxylic acid transport	GO:0046942	100	0.061
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.061	Mouse
cytokine production involved in immune response	GO:0002367	34	0.060
regulation of cell adhesion	GO:0030155	154	0.060
hindbrain development	GO:0030902	128	0.060	Mouse
glycosyl compound metabolic process	GO:1901657	246	0.059	Mouse
response to defenses of other organism involved in symbiotic interaction	GO:0052173	3	0.059
carbohydrate derivative catabolic process	GO:1901136	231	0.059	Mouse
microtubule cytoskeleton organization	GO:0000226	157	0.059
smooth muscle tissue development	GO:0048745	22	0.059
t cell differentiation in thymus	GO:0033077	77	0.058
positive regulation of immunological synapse formation	GO:2000522	1	0.058
positive regulation of protein kinase activity	GO:0045860	144	0.058
regulation of vasculogenesis	GO:2001212	9	0.058
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.057
embryonic epithelial tube formation	GO:0001838	130	0.057	Mouse
epidermis development	GO:0008544	187	0.057
negative regulation of cytoskeleton organization	GO:0051494	36	0.057
cytosolic calcium ion transport	GO:0060401	48	0.057
platelet derived growth factor receptor signaling pathway	GO:0048008	32	0.057
cell fate commitment	GO:0045165	210	0.056
ensheathment of neurons	GO:0007272	76	0.056
development of primary female sexual characteristics	GO:0046545	73	0.056
organic anion transport	GO:0015711	137	0.056
ribonucleoside catabolic process	GO:0042454	206	0.056	Mouse
muscle cell migration	GO:0014812	19	0.056
microtubule based process	GO:0007017	236	0.056
mating behavior sex discrimination	GO:0048047	1	0.056
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.056	Mouse
regulation of nucleotide catabolic process	GO:0030811	122	0.055	Mouse
hindbrain tangential cell migration	GO:0021934	2	0.055
cardiac muscle contraction	GO:0060048	32	0.055
tissue remodeling	GO:0048771	102	0.055
coagulation	GO:0050817	78	0.055
alpha beta t cell activation involved in immune response	GO:0002287	31	0.055	Mouse
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.055
carbohydrate metabolic process	GO:0005975	230	0.055
regulation of kinase activity	GO:0043549	249	0.055
positive regulation of transmembrane transport	GO:0034764	29	0.054
nuclear division	GO:0000280	158	0.054
digestive system development	GO:0055123	200	0.054
aromatic compound catabolic process	GO:0019439	286	0.054	Mouse
photoreceptor cell differentiation	GO:0046530	52	0.054
anatomical structure maturation	GO:0071695	49	0.054	Mouse
negative regulation of cell proliferation	GO:0008285	296	0.054
regulation of transferase activity	GO:0051338	263	0.053
ribonucleotide biosynthetic process	GO:0009260	59	0.053
regulation of neuron migration	GO:2001222	22	0.053	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.053	Mouse
cerebral cortex development	GO:0021987	86	0.053	Mouse
cell substrate adhesion	GO:0031589	130	0.053
regulation of ion transmembrane transporter activity	GO:0032412	54	0.053
regulation of defense response	GO:0031347	233	0.053
stem cell development	GO:0048864	219	0.052	Mouse
protein modification by small protein conjugation	GO:0032446	187	0.052
positive regulation of hydrolase activity	GO:0051345	148	0.052	Mouse
labyrinthine layer development	GO:0060711	49	0.052
regulation of voltage gated calcium channel activity	GO:1901385	4	0.052
cellular chemical homeostasis	GO:0055082	215	0.052
oligodendrocyte differentiation	GO:0048709	53	0.052
innate immune response	GO:0045087	157	0.052
associative learning	GO:0008306	61	0.051
multicellular organismal signaling	GO:0035637	91	0.051
t helper 2 cell differentiation	GO:0045064	12	0.051
protein catabolic process	GO:0030163	221	0.051
morphogenesis of embryonic epithelium	GO:0016331	159	0.051	Mouse
erythrocyte differentiation	GO:0030218	88	0.051
generation of precursor metabolites and energy	GO:0006091	103	0.051
regulation of alpha beta t cell differentiation	GO:0046637	35	0.050
phospholipid metabolic process	GO:0006644	87	0.050
negative regulation of cell morphogenesis involved in differentiation	GO:0010771	48	0.050	Mouse
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.050
regulation of apoptotic signaling pathway	GO:2001233	197	0.050
skin development	GO:0043588	220	0.050
actomyosin structure organization	GO:0031032	56	0.050
response to insulin	GO:0032868	100	0.049
multicellular organismal response to stress	GO:0033555	62	0.049
regulation of lymphocyte differentiation	GO:0045619	107	0.049
endothelial cell differentiation	GO:0045446	41	0.049
response to growth factor	GO:0070848	198	0.049
positive regulation of necrotic cell death	GO:0010940	1	0.048
salivary gland morphogenesis	GO:0007435	33	0.048	Mouse
regulation of leukocyte mediated immunity	GO:0002703	104	0.048
behavioral response to nutrient	GO:0051780	1	0.048
pigmentation	GO:0043473	71	0.048
negative regulation of neuron differentiation	GO:0045665	101	0.048	Mouse
lipid transport	GO:0006869	98	0.047
peptidyl serine phosphorylation	GO:0018105	74	0.047
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.047
sympathetic nervous system development	GO:0048485	22	0.047	Mouse
organelle localization	GO:0051640	179	0.047	Mouse
canonical wnt signaling pathway	GO:0060070	130	0.047
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.047
hypothalamic tangential migration using cell axon interactions	GO:0021856	3	0.047	Mouse
membrane lipid metabolic process	GO:0006643	53	0.046
t helper cell differentiation	GO:0042093	28	0.046	Mouse
purine ribonucleoside catabolic process	GO:0046130	205	0.046	Mouse
sequestering of metal ion	GO:0051238	19	0.046

Sema6d disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	cancer	DOID:162	0	0.078
	disease of cellular proliferation	DOID:14566	0	0.078

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