Mus musculus

83 known processes

Pde4a

phosphodiesterase 4A, cAMP specific

(Aliases: Dpde2,D9Ertd60e)

Pde4a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transmembrane transportGO:00550854120.218
Mouse
inorganic cation transmembrane transportGO:00986622070.198
Mouse
organophosphate catabolic processGO:00464342320.165
nucleobase containing small molecule metabolic processGO:00550863520.125
cation transportGO:00068123990.118
Mouse
carbohydrate derivative catabolic processGO:19011362310.097
inorganic ion transmembrane transportGO:00986602340.093
Mouse
membrane organizationGO:00610242450.089
ion transmembrane transportGO:00342203610.084
Mouse
synaptic transmissionGO:00072683290.083
Mouse Fly
regulation of cellular amino acid metabolic processGO:000652150.081
regulation of transmembrane transportGO:00347621280.071
Mouse
purine nucleoside catabolic processGO:00061522050.070
organic anion transportGO:00157111370.066
glycosyl compound catabolic processGO:19016582060.062
organic cyclic compound catabolic processGO:19013612950.060
rho protein signal transductionGO:0007266320.059
nucleoside phosphate metabolic processGO:00067533380.059
positive regulation of cellular catabolic processGO:00313311480.057
regulation of cellular amine metabolic processGO:0033238200.055
Mouse
cation transmembrane transportGO:00986552660.055
Mouse
cellular ketone metabolic processGO:0042180840.051
purine ribonucleotide metabolic processGO:00091502900.051
dorsal ventral axon guidanceGO:003356330.051
aromatic compound catabolic processGO:00194392860.051
positive regulation of cellular amine metabolic processGO:003324050.050
purine nucleoside metabolic processGO:00422782410.049
ribose phosphate metabolic processGO:00196932910.049
plasma membrane organizationGO:0007009900.049
synaptic transmission glutamatergicGO:0035249360.047
homeostasis of number of cellsGO:00488722100.047
Mouse
ribonucleoside metabolic processGO:00091192450.047
multicellular organismal signalingGO:0035637910.046
regulation of purine nucleotide catabolic processGO:00331211220.044
oxidation reduction processGO:00551143420.044
purine ribonucleoside triphosphate catabolic processGO:00092071990.043
regulation of cell migrationGO:00303342190.042
nucleoside triphosphate metabolic processGO:00091412300.041
ras protein signal transductionGO:0007265770.041
purine ribonucleoside triphosphate metabolic processGO:00092052200.041
endomembrane system organizationGO:00102561470.040
g protein coupled receptor signaling pathwayGO:00071862430.040
ribonucleoside triphosphate metabolic processGO:00091992200.040
apoptotic signaling pathwayGO:00971903060.039
purine ribonucleoside metabolic processGO:00461282410.038
ribonucleotide catabolic processGO:00092612080.038
small gtpase mediated signal transductionGO:0007264970.038
purine nucleotide metabolic processGO:00061633020.038
actin cytoskeleton organizationGO:00300362200.038
nucleotide catabolic processGO:00091662170.037
nuclear divisionGO:00002801580.037
regulation of inward rectifier potassium channel activityGO:190197910.037
regulation of membrane potentialGO:00423911920.037
regulation of metal ion transportGO:00109591060.036
Mouse
myeloid cell differentiationGO:00300992330.036
regulation of cellular catabolic processGO:00313292420.036
cellular amino acid metabolic processGO:00065201030.036
cellular lipid metabolic processGO:00442553230.035
cellular component assembly involved in morphogenesisGO:00109271390.035
organonitrogen compound catabolic processGO:19015652640.035
nucleoside triphosphate catabolic processGO:00091432050.035
renal sodium ion transportGO:000309620.034
protein localization to membraneGO:00726571080.033
purine containing compound metabolic processGO:00725213110.033
purine ribonucleotide catabolic processGO:00091542080.033
nucleoside metabolic processGO:00091162460.033
divalent metal ion transportGO:00708381720.033
Mouse
cellular nitrogen compound catabolic processGO:00442702800.033
regulation of cell activationGO:00508652890.033
regulation of ion transportGO:00432692150.033
Mouse
organelle fissionGO:00482851700.031
regulation of engulfment of apoptotic cellGO:190107420.031
hematopoietic progenitor cell differentiationGO:00022441430.031
amine metabolic processGO:0009308450.030
Mouse
nucleotide metabolic processGO:00091173320.030
ribonucleoside triphosphate catabolic processGO:00092031990.030
regulation of neurotransmitter levelsGO:0001505870.030
Mouse
purine nucleoside triphosphate metabolic processGO:00091442260.030
peptidyl amino acid modificationGO:00181933360.029
Mouse
purine ribonucleoside catabolic processGO:00461302050.029
regulation of g protein activated inward rectifier potassium channel activityGO:190012810.028
glycosyl compound metabolic processGO:19016572460.028
macromolecule catabolic processGO:00090572810.028
regulation of cellular ketone metabolic processGO:0010565660.028
glycerolipid metabolic processGO:00464861220.028
regulation of nucleoside metabolic processGO:00091181300.028
neuron deathGO:00709971540.028
immune response regulating signaling pathwayGO:00027641250.027
peptidyl serine phosphorylationGO:0018105740.027
Mouse
dephosphorylationGO:00163111290.027
g protein coupled acetylcholine receptor signaling pathwayGO:000721340.027
gtp metabolic processGO:00460391440.027
cellular amine metabolic processGO:0044106440.027
Mouse
protein catabolic processGO:00301632210.027
circulatory system processGO:00030131970.027
Mouse
synaptic vesicle localizationGO:0097479590.027
transmission of nerve impulseGO:0019226760.026
actin filament organizationGO:00070151130.026
purine nucleoside triphosphate catabolic processGO:00091462030.026
regulation of nucleotide catabolic processGO:00308111220.026
negative regulation of immune system processGO:00026832090.026
cellular protein complex assemblyGO:00436231160.026
potassium ion transportGO:0006813520.026
regulation of defense responseGO:00313472330.025
action potentialGO:0001508780.025
intracellular protein transportGO:00068862040.025
gtp catabolic processGO:00061841430.025
glycerophospholipid metabolic processGO:0006650710.025
neuron neuron synaptic transmissionGO:0007270690.024
regulation of cell motilityGO:20001452360.024
regulation of ion transmembrane transporter activityGO:0032412540.024
Mouse
anion transportGO:00068201770.024
fat cell differentiationGO:00454441600.024
meiotic cell cycleGO:00513211220.024
positive regulation of nucleoside metabolic processGO:0045979910.024
regulation of cellular component biogenesisGO:00440871810.023
sensory perceptionGO:00076002450.023
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.023
memoryGO:0007613580.023
Fly
regulation of ion transmembrane transportGO:00347651190.023
Mouse
regulation of cell cycleGO:00517262810.023
positive regulation of organelle organizationGO:00106381280.023
rac protein signal transductionGO:0016601130.023
leukocyte differentiationGO:00025213420.022
negative regulation of protein modification processGO:00314001630.022
Mouse
carbohydrate derivative biosynthetic processGO:19011371830.022
positive regulation of protein modification processGO:00314012990.022
positive regulation of nucleotide metabolic processGO:00459811140.022
regulation of organelle organizationGO:00330432890.022
single organism cell adhesionGO:00986021560.022
adult behaviorGO:00305341350.022
neuron apoptotic processGO:00514021420.022
wnt signaling pathwayGO:00160551880.021
muscle contractionGO:00069361010.021
Mouse
establishment of vesicle localizationGO:0051650810.021
regulation of voltage gated calcium channel activityGO:190138540.021
Mouse
t cell activationGO:00421102890.021
regulation of gtp catabolic processGO:00331241130.021
peptidyl tyrosine phosphorylationGO:00181081430.021
positive regulation of cell developmentGO:00107202370.021
purine nucleotide catabolic processGO:00061952110.021
protein targetingGO:00066051430.021
response to molecule of bacterial originGO:00022371430.021
Mouse
positive regulation of purine nucleotide catabolic processGO:0033123880.021
peptidyl tyrosine modificationGO:00182121450.021
positive regulation of homeostatic processGO:0032846640.021
activation of immune responseGO:00022531380.020
cardiac muscle cell contractionGO:008600370.020
Mouse
organelle localizationGO:00516401790.020
negative regulation of cell activationGO:00508661110.020
engulfment of apoptotic cellGO:004365230.020
inflammatory responseGO:00069542440.020
establishment of protein localization to membraneGO:0090150540.020
energy derivation by oxidation of organic compoundsGO:0015980770.020
positive regulation of leukocyte differentiationGO:1902107860.020
negative regulation of cell motilityGO:2000146610.019
regulation of lymphocyte activationGO:00512492400.019
protein localization to plasma membraneGO:0072659570.019
regulation of cardiac muscle contractionGO:0055117210.019
Mouse
posttranscriptional regulation of gene expressionGO:00106081550.019
adult locomotory behaviorGO:0008344910.019
positive regulation of cellular amino acid metabolic processGO:004576430.019
cytoplasmic transportGO:00164822340.019
Mouse
regulation of synaptic growth at neuromuscular junctionGO:000858240.019
compound eye developmentGO:004874910.019
regulation of calcium ion transmembrane transporter activityGO:1901019200.019
Mouse
regulation of body fluid levelsGO:00508781620.018
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activityGO:2000311110.018
positive regulation of gtp catabolic processGO:0033126850.018
rna interferenceGO:001624620.018
guanosine containing compound metabolic processGO:19010681440.018
regulation of vesicle mediated transportGO:00606271390.018
spermatogenesisGO:00072832840.018
regulation of actin filament based processGO:0032970990.018
Mouse
mapk cascadeGO:00001652810.017
positive regulation of apoptotic processGO:00430652170.017
regulation of apoptotic signaling pathwayGO:20012331970.017
tissue homeostasisGO:00018941150.017
nucleoside phosphate catabolic processGO:19012922220.017
stem cell differentiationGO:00488632680.017
positive regulation of cell morphogenesis involved in differentiationGO:0010770720.017
positive regulation of protein phosphorylationGO:00019342420.017
microtubule based processGO:00070172360.017
positive regulation of membrane protein ectodomain proteolysisGO:005104430.017
lymphocyte differentiationGO:00300982420.017
nucleoside catabolic processGO:00091642060.017
ribonucleoside catabolic processGO:00424542060.017
male gamete generationGO:00482322850.017
cellular response to biotic stimulusGO:0071216920.017
Mouse
mitotic cell cycle processGO:19030471590.017
regulation of transporter activityGO:0032409570.016
Mouse
cellular response to organonitrogen compoundGO:00714171450.016
Mouse
regulation of purine nucleotide metabolic processGO:19005421690.016
proteolysis involved in cellular protein catabolic processGO:00516031470.016
ribonucleoside monophosphate metabolic processGO:0009161800.016
heterocycle catabolic processGO:00467002800.016
positive regulation of purine nucleotide metabolic processGO:19005441140.016
calcium ion transmembrane transportGO:0070588850.016
Mouse
amino acid transportGO:0006865610.016
locomotory behaviorGO:00076261950.016
Mouse
l glutamate import into cellGO:199012330.016
regulation of establishment of protein localizationGO:00702011810.016
neuronal action potentialGO:0019228540.016
cation homeostasisGO:00550802120.016
Mouse
lipid modificationGO:0030258650.016
ensheathment of neuronsGO:0007272760.016
modification dependent protein catabolic processGO:00199411330.016
calcium ion transportGO:00068161590.016
Mouse
regulation of glutamate receptor signaling pathwayGO:1900449160.015
regulation of myeloid cell differentiationGO:0045637960.015
potassium ion homeostasisGO:005507540.015
synaptic vesicle transportGO:0048489570.015
regulation of nucleotide metabolic processGO:00061401690.015
organic acid transportGO:00158491010.015
guanosine containing compound catabolic processGO:19010691440.015
male meiosisGO:0007140370.015
cellular protein catabolic processGO:00442571550.015
immune response regulating cell surface receptor signaling pathwayGO:0002768800.015
potassium ion importGO:001010710.015
sodium ion transportGO:0006814730.015
cellular response to acid chemicalGO:0071229680.015
negative regulation of protein phosphorylationGO:00019331260.015
Mouse
response to acid chemicalGO:00011011110.015
positive regulation of nervous system developmentGO:00519622210.015
regulation of system processGO:00440572000.015
Mouse
regulation of cell projection organizationGO:00313442060.015
purine containing compound catabolic processGO:00725232130.015
amino acid import into cellGO:190283740.014
regulation of inflammatory responseGO:00507271470.014
regulation of cytoskeleton organizationGO:00514931220.014
negative regulation of phosphate metabolic processGO:00459361840.014
Mouse
regulation of neuron deathGO:19012141340.014
male anatomical structure morphogenesisGO:009059840.014
defecationGO:003042110.014
skeletal system developmentGO:00015013560.014
cell growthGO:00160491300.014
Fly
spermatid differentiationGO:00485151150.014
ribonucleotide metabolic processGO:00092592910.014
response to organic cyclic compoundGO:00140701980.014
Mouse
axonogenesisGO:00074092740.014
Fly
phosphatidylinositol metabolic processGO:0046488450.014
regulation of receptor activityGO:0010469410.014
regulation of canonical wnt signaling pathwayGO:0060828820.014
maintenance of locationGO:0051235890.014
intracellular mrna localizationGO:000829840.014
regulation of cation channel activityGO:2001257220.014
Mouse
regulation of protein transportGO:00512231630.014
synapse assemblyGO:0007416560.014
regulation of epithelial cell proliferationGO:00506781410.014
regulation of response to woundingGO:19030341890.014
positive regulation of renal sodium excretionGO:003581520.014
epithelial cell proliferationGO:00506731740.014
organelle assemblyGO:00709251770.014
osteoclast differentiationGO:0030316620.014
regulation of resting membrane potentialGO:006007530.014
blood circulationGO:00080151950.014
Mouse
regulation of fat cell differentiationGO:0045598810.014
actomyosin structure organizationGO:0031032560.014
prevention of polyspermyGO:006046840.014
single fertilizationGO:0007338820.013
immune response activating signal transductionGO:00027571160.013
negative regulation of phosphorylationGO:00423261660.013
Mouse
cellular potassium ion transportGO:0071804430.013
glycoprotein biosynthetic processGO:0009101890.013
response to lipopolysaccharideGO:00324961280.013
Mouse
negative regulation of protein metabolic processGO:00512482820.013
Mouse
establishment of endothelial blood brain barrierGO:001404530.013
regulation of long term synaptic depressionGO:190045230.013
cellular response to hormone stimulusGO:00328701500.013
positive regulation of cytoskeleton organizationGO:0051495490.013
leukocyte migrationGO:00509001240.013
Mouse
modification dependent macromolecule catabolic processGO:00436321330.013
embryonic genitalia morphogenesisGO:003053840.013
lipid biosynthetic processGO:00086101790.013
positive regulation of mapk cascadeGO:00434101700.013
protein autophosphorylationGO:0046777610.013
organophosphate ester transportGO:0015748280.013
positive regulation of neuron projection developmentGO:0010976790.013
nucleoside monophosphate metabolic processGO:0009123850.013
divalent inorganic cation transportGO:00725111780.013
Mouse
positive regulation of phagocytosis engulfmentGO:006010030.013
positive regulation of cell projection organizationGO:0031346950.013
ubiquitin dependent protein catabolic processGO:00065111290.013
glycoprotein metabolic processGO:00091001160.013
regulation of homeostatic processGO:00328441820.013
Mouse
purine ribonucleoside monophosphate metabolic processGO:0009167800.013
regulation of hydrolase activityGO:00513362460.013
regulation of leukocyte proliferationGO:00706631210.013
regulation of cell substrate adhesionGO:0010810730.013
developmental maturationGO:00217001930.013
leukocyte homeostasisGO:0001776790.013
Mouse
negative regulation of cellular amine metabolic processGO:003323910.013
regulation of t cell activationGO:00508631700.013
positive regulation of nucleotide catabolic processGO:0030813880.013
carboxylic acid transportGO:00469421000.013
establishment of organelle localizationGO:00516561220.013
regulation of protein secretionGO:0050708820.012
cell adhesionGO:00071553290.012
exocytosisGO:00068871210.012
positive regulation of hydrolase activityGO:00513451480.012
glutamate receptor signaling pathwayGO:0007215350.012
actin filament based movementGO:0030048230.012
Mouse
vesicle organizationGO:0016050600.012
substantia nigra developmentGO:002176220.012
actin mediated cell contractionGO:0070252150.012
Mouse
protein modification by small protein conjugationGO:00324461870.012
negative regulation of neuron apoptotic processGO:0043524920.012
amino acid uptake involved in synaptic transmissionGO:005193330.012
l glutamate uptake involved in synaptic transmissionGO:005193530.012
positive regulation of rho gtpase activityGO:0032321410.012
cell type specific apoptotic processGO:00972852680.012
carbohydrate metabolic processGO:00059752300.012
organonitrogen compound biosynthetic processGO:19015661920.012
response to inorganic substanceGO:0010035960.012
microtubule cytoskeleton organizationGO:00002261570.012
establishment of synaptic vesicle localizationGO:0097480570.012
mitotic cell cycleGO:00002781950.012
cell activation involved in immune responseGO:00022631260.012
purine nucleoside monophosphate metabolic processGO:0009126810.012
protein kinase b signalingGO:0043491740.012
molting cycleGO:0042303900.012
neuromuscular processGO:0050905990.012
peptidyl serine modificationGO:0018209830.012
Mouse
cellular response to dna damage stimulusGO:00069742070.012
positive regulation of ion transportGO:0043270650.012
mesodermal cell migrationGO:000807840.012
positive regulation of cellular component biogenesisGO:0044089940.012
asymmetric neuroblast divisionGO:005505910.012
regulation of protein kinase activityGO:00458592320.011
protein modification by small protein conjugation or removalGO:00706472070.011
positive regulation of cytosolic calcium ion concentrationGO:0007204650.011
Mouse
response to radiationGO:00093141650.011
Mouse
monovalent inorganic cation homeostasisGO:0055067330.011
single organismal cell cell adhesionGO:00163371310.011
cardiac muscle cell action potentialGO:0086001110.011
wound healingGO:00420601570.011
response to painGO:0048265260.011
regulation of ras protein signal transductionGO:00465781140.011
regulation of secretion by cellGO:19035302490.011
mitotic cytokinesisGO:000028140.011
regulation of proteolysisGO:00301621640.011
axon ensheathmentGO:0008366760.011
generation of precursor metabolites and energyGO:00060911030.011
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188540.011
cognitionGO:00508901490.011
Mouse Fly
regulation of intracellular transportGO:00323861590.011
Mouse
nitrogen compound transportGO:00717052710.011
neurotransmitter secretionGO:0007269620.011
negative regulation of phosphorus metabolic processGO:00105631840.011
Mouse
regulation of membrane protein ectodomain proteolysisGO:005104330.011
regulation of mitotic cell cycle phase transitionGO:1901990730.011
arp2 3 complex mediated actin nucleationGO:003431430.011
microtubule cytoskeleton organization involved in mitosisGO:190285040.011
organophosphate biosynthetic processGO:00904071220.011
cell junction organizationGO:0034330770.011
positive regulation of apoptotic cell clearanceGO:200042730.011
telencephalon developmentGO:00215371860.011
regulation of calcium ion transmembrane transportGO:1903169200.011
Mouse
regulation of cell cycle processGO:00105641600.011
cellular homeostasisGO:00197252400.011
Mouse
nuclear transportGO:00511691390.011
positive regulation of defense responseGO:00313491240.011
phosphatidylethanolamine metabolic processGO:004633720.011
negative regulation of cell proliferationGO:00082852960.011
macromolecule methylationGO:00434141200.011
anatomical structure maturationGO:0071695490.011
cellular metal ion homeostasisGO:00068751510.011
Mouse
reactive oxygen species metabolic processGO:0072593840.011
blood vessel morphogenesisGO:00485142850.011
immune effector processGO:00022523210.011
regulation of anatomical structure sizeGO:00900661780.011
dicarboxylic acid transportGO:0006835290.010
fatty acid metabolic processGO:00066311210.010
regulation of cell growthGO:0001558910.010
sequestering of metal ionGO:0051238190.010
response to light stimulusGO:00094161350.010
Mouse
acid secretionGO:0046717330.010
camp metabolic processGO:0046058400.010
behavioral response to nutrientGO:005178010.010
regulation of cell sizeGO:0008361720.010
positive regulation of gtpase activityGO:0043547850.010
negative regulation of molecular functionGO:00440922580.010
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.010
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161880.010
directional locomotionGO:003305830.010
vesicle localizationGO:0051648860.010
cellular polysaccharide metabolic processGO:0044264380.010
actin filament bundle assemblyGO:0051017400.010
regulation of leukocyte differentiationGO:19021051590.010
protein polymerizationGO:0051258570.010
cell cell junction organizationGO:0045216720.010
cellular response to insulin stimulusGO:0032869780.010
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.010

Pde4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
muscle tissue diseaseDOID:6600.039
muscular diseaseDOID:008000000.039
musculoskeletal system diseaseDOID:1700.039
disease of anatomical entityDOID:700.039
nervous system diseaseDOID:86300.037
central nervous system diseaseDOID:33100.031
brain diseaseDOID:93600.026
epilepsy syndromeDOID:182600.026
electroclinical syndromeDOID:005070100.026
cancerDOID:16200.017
disease of cellular proliferationDOID:1456600.017
organ system cancerDOID:005068600.015
cardiovascular system diseaseDOID:128700.011
connective tissue diseaseDOID:6500.011
bone diseaseDOID:008000100.011