Mus musculus

12 known processes

Adamts5

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

(Aliases: ADAMTS1,9530092O11Rik,AI481094,ADAMTS11,ADAM-TS5,ASMP-2)

Adamts5 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
extracellular matrix organizationGO:00301981470.195
Mouse
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.158
extracellular structure organizationGO:00430621480.137
Mouse
kidney developmentGO:00018222130.112
Mouse
positive regulation of peptidase activityGO:0010952490.104
bone developmentGO:00603481200.099
renal system developmentGO:00720012250.095
Mouse
regulation of cellular ketone metabolic processGO:0010565660.095
positive regulation of cellular amine metabolic processGO:003324050.091
camera type eye developmentGO:00430102660.091
transmembrane transportGO:00550854120.090
negative regulation of cell proliferationGO:00082852960.090
skin developmentGO:00435882200.085
reactive oxygen species metabolic processGO:0072593840.076
respiratory system developmentGO:00605411900.074
respiratory tube developmentGO:00303231670.073
apoptotic signaling pathwayGO:00971903060.067
regulation of cellular amine metabolic processGO:0033238200.064
cation transportGO:00068123990.064
epithelial tube morphogenesisGO:00605623030.062
positive regulation of proteolysisGO:0045862850.054
response to radiationGO:00093141650.053
stem cell differentiationGO:00488632680.053
cell adhesionGO:00071553290.053
connective tissue developmentGO:00614481790.052
regulation of apoptotic signaling pathwayGO:20012331970.051
sensory organ morphogenesisGO:00905962420.050
regulation of peptidase activityGO:0052547960.048
positive regulation of nervous system developmentGO:00519622210.047
generation of precursor metabolites and energyGO:00060911030.045
anatomical structure homeostasisGO:00602491450.044
collagen fibril organizationGO:0030199320.044
regulation of endopeptidase activityGO:0052548890.043
regulation of hydrolase activityGO:00513362460.043
regulation of neuron projection developmentGO:00109751690.042
lung developmentGO:00303241640.042
compound eye developmentGO:004874910.042
response to organic cyclic compoundGO:00140701980.041
single organismal cell cell adhesionGO:00163371310.040
chondrocyte differentiationGO:0002062720.038
endocytosisGO:00068971680.038
heart morphogenesisGO:00030071780.037
Mouse
regulation of proteolysisGO:00301621640.037
nephron developmentGO:00720061090.037
skeletal system developmentGO:00015013560.037
response to amino acidGO:0043200370.037
response to growth factorGO:00708481980.036
cellular amine metabolic processGO:0044106440.036
small gtpase mediated signal transductionGO:0007264970.036
regulation of transmembrane transportGO:00347621280.035
cellular response to growth factor stimulusGO:00713631970.035
positive regulation of cellular amino acid metabolic processGO:004576430.034
tube formationGO:00351481400.034
regulation of system processGO:00440572000.034
engulfment of apoptotic cellGO:004365230.033
ear morphogenesisGO:00424711180.033
regulation of cellular amino acid metabolic processGO:000652150.033
negative regulation of protein metabolic processGO:00512482820.033
striated muscle tissue developmentGO:00147062930.033
cartilage developmentGO:00512161400.033
morphogenesis of embryonic epitheliumGO:00163311590.033
urogenital system developmentGO:00016552610.031
Mouse
oxidation reduction processGO:00551143420.031
negative regulation of cellular component organizationGO:00511291940.031
forebrain developmentGO:00309003020.031
negative regulation of cellular amine metabolic processGO:003323910.031
intrinsic apoptotic signaling pathwayGO:00971931320.031
muscle tissue developmentGO:00605373080.031
positive regulation of endopeptidase activityGO:0010950430.031
ear developmentGO:00435832000.030
sensory system developmentGO:004888030.030
protein modification by small protein conjugation or removalGO:00706472070.030
cellular amino acid metabolic processGO:00065201030.029
muscle cell differentiationGO:00426922610.029
amine metabolic processGO:0009308450.029
cellular response to amino acid stimulusGO:0071230290.029
telencephalon developmentGO:00215371860.029
negative regulation of apoptotic signaling pathwayGO:20012341040.028
cardiac chamber developmentGO:00032051080.028
Mouse
neural tube developmentGO:00219151600.028
embryonic epithelial tube formationGO:00018381300.028
regulation of cytokine productionGO:00018172660.028
dendrite developmentGO:00163581150.028
nitrogen compound transportGO:00717052710.027
ras protein signal transductionGO:0007265770.027
neural tube formationGO:00018411080.027
immune effector processGO:00022523210.027
b cell activationGO:00421131610.027
regulation of organ morphogenesisGO:20000271440.027
response to oxidative stressGO:00069791230.027
peptidyl amino acid modificationGO:00181933360.027
positive regulation of cell substrate adhesionGO:0010811470.027
regulation of kinase activityGO:00435492490.027
epidermis developmentGO:00085441870.026
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.026
regulation of cell cycleGO:00517262810.026
skeletal system morphogenesisGO:00487052030.026
cell substrate adhesionGO:00315891300.026
elastic fiber assemblyGO:004825140.026
regulation of protein kinase activityGO:00458592320.026
regulation of reactive oxygen species metabolic processGO:2000377400.026
protein modification by small protein conjugationGO:00324461870.026
protein processingGO:00164851630.025
cytokine productionGO:00018163190.025
inter male aggressive behaviorGO:000212130.025
physiological cardiac muscle hypertrophyGO:000330130.025
cellular ketone metabolic processGO:0042180840.025
developmental maturationGO:00217001930.025
appendage developmentGO:00487361660.025
response to transforming growth factor betaGO:0071559880.024
divalent metal ion transportGO:00708381720.024
tissue homeostasisGO:00018941150.024
posttranscriptional regulation of gene expressionGO:00106081550.024
cellular response to abiotic stimulusGO:0071214560.024
protein maturationGO:00516041760.024
positive regulation of cell deathGO:00109422240.023
organelle fissionGO:00482851700.023
palate developmentGO:0060021760.023
response to endoplasmic reticulum stressGO:0034976530.023
cellular response to organonitrogen compoundGO:00714171450.023
sensory perceptionGO:00076002450.023
positive regulation of protein modification processGO:00314012990.022
trunk segmentationGO:003529040.022
digestive system developmentGO:00551232000.022
positive regulation of programmed cell deathGO:00430682180.022
extrinsic apoptotic signaling pathwayGO:00971911260.022
negative regulation of cellular amino acid metabolic processGO:004576300.022
peptidyl tyrosine modificationGO:00182121450.022
regulation of ion transportGO:00432692150.022
blood vessel morphogenesisGO:00485142850.022
striated muscle cell developmentGO:00550021250.022
epithelial cell proliferationGO:00506731740.022
synapse organizationGO:00508081250.022
peptidyl tyrosine phosphorylationGO:00181081430.021
acetylcholine secretion neurotransmissionGO:001405520.021
phagocytosisGO:0006909660.021
cellular response to acid chemicalGO:0071229680.021
regulation of cell motilityGO:20001452360.021
negative regulation of intracellular signal transductionGO:19025321670.021
female gonad developmentGO:0008585710.021
Mouse
transforming growth factor beta receptor signaling pathwayGO:0007179710.020
mitotic cell cycleGO:00002781950.020
negative regulation of phosphorylationGO:00423261660.020
negative regulation of phosphorus metabolic processGO:00105631840.020
cellular response to transforming growth factor beta stimulusGO:0071560880.020
regulation of fibroblast proliferationGO:0048145340.020
response to organonitrogen compoundGO:00102432460.020
negative regulation of catenin import into nucleusGO:003541420.020
energy derivation by oxidation of organic compoundsGO:0015980770.020
cellular lipid metabolic processGO:00442553230.020
organelle localizationGO:00516401790.020
renal tubule morphogenesisGO:0061333720.019
regulation of bmp signaling pathwayGO:0030510600.019
mitotic cell cycle processGO:19030471590.019
organelle assemblyGO:00709251770.019
regulation of organelle organizationGO:00330432890.019
regulation of cell projection organizationGO:00313442060.019
cellular response to oxidative stressGO:0034599760.019
cellular response to fibroblast growth factor stimulusGO:0044344470.019
innate immune responseGO:00450871570.019
response to lipopolysaccharideGO:00324961280.019
locomotory behaviorGO:00076261950.019
ion transmembrane transportGO:00342203610.018
regulation of cell cycle processGO:00105641600.018
regulation of lymphocyte activationGO:00512492400.018
branching morphogenesis of an epithelial tubeGO:00487541590.018
intracellular receptor signaling pathwayGO:0030522740.018
development of primary sexual characteristicsGO:00451371430.018
Mouse Worm
cytoplasmic transportGO:00164822340.018
Worm
lateral line system developmentGO:004892510.018
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.018
kidney morphogenesisGO:0060993830.018
negative regulation of protein modification processGO:00314001630.018
retina development in camera type eyeGO:00600411190.018
negative regulation of growthGO:0045926990.017
regulation of angiogenesisGO:0045765810.017
reactive oxygen species biosynthetic processGO:190340980.017
regulation of cellular component biogenesisGO:00440871810.017
establishment of organelle localizationGO:00516561220.017
organic hydroxy compound metabolic processGO:19016152030.017
bone morphogenesisGO:0060349780.017
protein ubiquitinationGO:00165671710.017
epithelium migrationGO:0090132630.017
mesoderm developmentGO:00074981000.017
limb morphogenesisGO:00351081490.017
nucleoside phosphate metabolic processGO:00067533380.017
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.017
tissue remodelingGO:00487711020.017
negative regulation of epithelial cell proliferationGO:0050680640.017
hematopoietic progenitor cell differentiationGO:00022441430.017
regulation of neuron differentiationGO:00456642810.017
tube closureGO:0060606910.017
regulation of endocytosisGO:0030100690.017
regionalizationGO:00030023370.017
regulation of mitotic cell cycleGO:00073461260.017
positive regulation of cell adhesionGO:0045785800.017
regulation of cell migrationGO:00303342190.017
endomembrane system organizationGO:00102561470.017
regulation of hormone levelsGO:00108172110.017
embryonic organ morphogenesisGO:00485622760.016
ceramide biosynthetic processGO:0046513200.016
angiogenesisGO:00015252010.016
protein oligomerizationGO:0051259670.016
regulation of cell activationGO:00508652890.016
lateral inhibitionGO:004633110.016
biomineral tissue developmentGO:0031214640.016
sensory perception of mechanical stimulusGO:00509541070.016
smoothened signaling pathwayGO:00072241050.016
negative regulation of cell developmentGO:00107211690.016
telencephalon cell migrationGO:0022029550.016
sequestering of calcium ionGO:0051208180.016
rhythmic processGO:00485111740.016
Mouse
regulation of cellular response to stressGO:00801351590.016
adult behaviorGO:00305341350.016
regulation of wnt signaling pathwayGO:00301111230.016
divalent inorganic cation transportGO:00725111780.016
membrane organizationGO:00610242450.016
regulation of membrane potentialGO:00423911920.016
nuclear divisionGO:00002801580.015
negative regulation of ossificationGO:0030279490.015
microtubule based processGO:00070172360.015
acetylcholine transportGO:001587020.015
myeloid cell differentiationGO:00300992330.015
defense response to other organismGO:00985421970.015
mitochondrion organizationGO:00070051340.015
pallium developmentGO:00215431200.015
regulation of cysteine type endopeptidase activityGO:2000116650.015
positive regulation of apoptotic signaling pathwayGO:2001235950.015
morphogenesis of a branching epitheliumGO:00611381930.015
cardiac muscle tissue developmentGO:00487381300.015
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.015
signal transduction in absence of ligandGO:0038034550.015
regulation of cell growth involved in cardiac muscle cell developmentGO:006105030.015
positive regulation of kinase activityGO:00336741550.015
acetate ester transportGO:190137420.015
cardiac ventricle developmentGO:0003231830.014
regulation of organ growthGO:0046620610.014
cellular response to lipidGO:00713961450.014
regulation of cell adhesionGO:00301551540.014
nephron epithelium developmentGO:0072009920.014
physiological muscle hypertrophyGO:000329830.014
neuron migrationGO:00017641220.014
ameboidal type cell migrationGO:00016671280.014
muscle cell developmentGO:00550011330.014
cell growthGO:00160491300.014
nephron tubule developmentGO:0072080840.014
epithelial cell migrationGO:0010631630.014
cell growth involved in cardiac muscle cell developmentGO:006104930.014
positive regulation of apoptotic processGO:00430652170.014
macromolecule catabolic processGO:00090572810.014
heart contractionGO:0060047930.014
neuromuscular processGO:0050905990.014
spinal cord developmentGO:0021510810.014
inner ear morphogenesisGO:00424721010.014
regulation of protein processingGO:0070613960.014
regulation of ossificationGO:00302781120.014
positive regulation of mapk cascadeGO:00434101700.014
cellular glucan metabolic processGO:0006073320.014
positive regulation of cysteine type endopeptidase activityGO:2001056390.014
sequestering of metal ionGO:0051238190.014
cardiac chamber morphogenesisGO:0003206930.014
Mouse
positive regulation of defense responseGO:00313491240.014
neurotransmitter transportGO:0006836760.014
negative regulation of transforming growth factor beta receptor signaling pathwayGO:0030512260.014
cellular carbohydrate metabolic processGO:00442621190.014
regulation of transferase activityGO:00513382630.013
positive regulation of neuron differentiationGO:00456661410.013
establishment of planar polarityGO:0001736280.013
cellular macromolecule catabolic processGO:00442652060.013
negative regulation of nervous system developmentGO:00519611560.013
cellular response to inorganic substanceGO:0071241370.013
positive regulation of interleukin 8 productionGO:003275720.013
single organism cell adhesionGO:00986021560.013
sensory perception of light stimulusGO:0050953540.013
multicellular organismal homeostasisGO:00488711640.013
inorganic cation transmembrane transportGO:00986622070.013
metal ion homeostasisGO:00550651890.013
negative regulation of cellular protein metabolic processGO:00322692470.013
spermatogenesisGO:00072832840.013
meiotic cell cycleGO:00513211220.013
ureteric bud morphogenesisGO:0060675620.013
morphogenesis of a branching structureGO:00017632030.013
cell fate commitmentGO:00451652100.013
embryonic placenta developmentGO:0001892980.013
neural tube closureGO:0001843900.013
digestive tract developmentGO:00485651900.013
skeletal muscle satellite cell maintenance involved in skeletal muscle regenerationGO:001483430.013
establishment of tissue polarityGO:0007164280.013
cellular protein complex assemblyGO:00436231160.013
positive regulation of phospholipase activityGO:001051830.013
mesonephros developmentGO:0001823970.013
response to acid chemicalGO:00011011110.013
regulation of neurotransmitter levelsGO:0001505870.013
positive regulation of protein kinase activityGO:00458601440.013
positive regulation of cytokine productionGO:00018191740.013
cellular response to lipopolysaccharideGO:0071222770.013
response to inorganic substanceGO:0010035960.013
female gamete generationGO:0007292740.013
Mouse
cell cell adhesionGO:0098609410.013
mesonephric duct morphogenesisGO:007218040.013
ossificationGO:00015032160.013
hair follicle developmentGO:0001942850.013
negative regulation of cell cycleGO:00457861230.013
organonitrogen compound biosynthetic processGO:19015661920.013
cell junction organizationGO:0034330770.012
sensory perception of soundGO:0007605970.012
canonical wnt signaling pathwayGO:00600701300.012
ureteric bud developmentGO:0001657940.012
lipid biosynthetic processGO:00086101790.012
aromatic compound catabolic processGO:00194392860.012
hormone secretionGO:00468791280.012
fibroblast proliferationGO:0048144350.012
covalent chromatin modificationGO:00165691630.012
cellular ion homeostasisGO:00068731650.012
leukocyte proliferationGO:00706611720.012
sphingolipid metabolic processGO:0006665450.012
regulation of cell morphogenesis involved in differentiationGO:00107691510.012
wnt signaling pathwayGO:00160551880.012
response to molecule of bacterial originGO:00022371430.012
bmp signaling pathwayGO:0030509930.012
negative regulation of organelle organizationGO:0010639900.012
primary neural tube formationGO:0014020950.012
positive regulation of homeostatic processGO:0032846640.012
cognitionGO:00508901490.012
membrane lipid metabolic processGO:0006643530.012
glial cell differentiationGO:00100011310.012
extrinsic apoptotic signaling pathway in absence of ligandGO:0097192550.012
regulation of epithelial cell proliferationGO:00506781410.012
labyrinthine layer developmentGO:0060711490.012
glycogen metabolic processGO:0005977320.012
gland developmentGO:00487323300.012
negative regulation of phosphate metabolic processGO:00459361840.012
regulation of ion homeostasisGO:2000021640.012
embryonic skeletal system developmentGO:00487061200.012
regulation of actin filament based processGO:0032970990.012
polysaccharide metabolic processGO:0005976390.012
cellular response to superoxideGO:0071451140.012
cellular component assembly involved in morphogenesisGO:00109271390.012
cation homeostasisGO:00550802120.012
lung alveolus developmentGO:0048286450.012
regulation of intracellular transportGO:00323861590.012
cellular response to molecule of bacterial originGO:0071219830.012
membrane lipid biosynthetic processGO:0046467320.012
heterocycle catabolic processGO:00467002800.011
cellular polysaccharide metabolic processGO:0044264380.011
cation transmembrane transportGO:00986552660.011
protein localization to organelleGO:00333651850.011
regulation of osteoblast differentiationGO:0045667670.011
cellular response to dna damage stimulusGO:00069742070.011
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.011
somite developmentGO:0061053810.011
positive regulation of cell projection organizationGO:0031346950.011
negative regulation of bmp signaling pathwayGO:0030514350.011
meiotic cell cycle processGO:1903046770.011
development of primary female sexual characteristicsGO:0046545730.011
Mouse
monocarboxylic acid metabolic processGO:00327871910.011
positive regulation of reactive oxygen species metabolic processGO:2000379110.011
regulation of testosterone biosynthetic processGO:200022420.011
negative regulation of molecular functionGO:00440922580.011
forebrain cell migrationGO:0021885580.011
regulation of cell substrate adhesionGO:0010810730.011
endothelial cell migrationGO:0043542440.011
regulation of cellular response to growth factor stimulusGO:0090287820.011
positive regulation of transferase activityGO:00513471670.011
kidney epithelium developmentGO:00720731210.011
neurotransmitter secretionGO:0007269620.011
regulation of removal of superoxide radicalsGO:200012140.011
regulation of muscle tissue developmentGO:1901861970.011
regulation of mapk cascadeGO:00434082480.011
organ growthGO:00352651170.011
regulation of cytoplasmic transportGO:19036491120.011
rho protein signal transductionGO:0007266320.011
male gamete generationGO:00482322850.011
regulation of translationGO:0006417710.011
regulation of sphingolipid biosynthetic processGO:009015310.011
translationGO:0006412930.011
regulation of homeostatic processGO:00328441820.011
regulation of b cell activationGO:0050864810.011
cerebral cortex developmentGO:0021987860.011
blood circulationGO:00080151950.010
midgut developmentGO:000749440.010
response to reactive oxygen speciesGO:0000302560.010
epithelial tube formationGO:00721751300.010
sphingolipid biosynthetic processGO:0030148260.010
reactive nitrogen species metabolic processGO:200105700.010
limb developmentGO:00601731660.010
regulation of stem cell proliferationGO:0072091780.010
epithelial cell developmentGO:00020641590.010
response to oxygen radicalGO:0000305160.010
developmental programmed cell deathGO:0010623410.010
wound healingGO:00420601570.010
cellular response to biotic stimulusGO:0071216920.010
response to decreased oxygen levelsGO:0036293590.010
meiotic nuclear divisionGO:00071261150.010
spermatid developmentGO:00072861080.010
intracellular protein transportGO:00068862040.010

Adamts5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.083
musculoskeletal system diseaseDOID:1700.083
muscle tissue diseaseDOID:6600.076
muscular diseaseDOID:008000000.076
myopathyDOID:42300.076
nervous system diseaseDOID:86300.048
sensory system diseaseDOID:005015500.021
eye and adnexa diseaseDOID:149200.021
eye diseaseDOID:561400.018
retinal diseaseDOID:567900.018
retinal degenerationDOID:846600.018
cardiovascular system diseaseDOID:128700.017
heart diseaseDOID:11400.017
cardiomyopathyDOID:005070000.017
intrinsic cardiomyopathyDOID:006003600.015
central nervous system diseaseDOID:33100.013
disease of cellular proliferationDOID:1456600.010
cancerDOID:16200.010