IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Sil1

endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)

(Aliases: AI042831,wz,1810057E01Rik)

Ensembl: ENSMUSG00000024357
Entrez: 81500
UniProtKB: Q9EPK6

Process Predictions
Disease Predictions

Sil1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cellular amino acid metabolic process	GO:0006520	103	0.091
ketone catabolic process	GO:0042182	3	0.065
amine metabolic process	GO:0009308	45	0.051
regulation of cellular amino acid metabolic process	GO:0006521	5	0.045
cellular ketone metabolic process	GO:0042180	84	0.042
regulation of cellular ketone metabolic process	GO:0010565	66	0.041
nucleobase containing small molecule metabolic process	GO:0055086	352	0.037
oxidation reduction process	GO:0055114	342	0.036
macromolecule catabolic process	GO:0009057	281	0.036
lipid biosynthetic process	GO:0008610	179	0.033
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.031
cellular lipid metabolic process	GO:0044255	323	0.031
regulation of cellular amine metabolic process	GO:0033238	20	0.030
cellular macromolecule catabolic process	GO:0044265	206	0.030
positive regulation of cellular amine metabolic process	GO:0033240	5	0.028
regulation of membrane potential	GO:0042391	192	0.028
cellular amine metabolic process	GO:0044106	44	0.028
organonitrogen compound biosynthetic process	GO:1901566	192	0.027
organic hydroxy compound metabolic process	GO:1901615	203	0.027
small molecule biosynthetic process	GO:0044283	132	0.026
carbohydrate metabolic process	GO:0005975	230	0.026
peptidyl amino acid modification	GO:0018193	336	0.025
cofactor metabolic process	GO:0051186	80	0.024
transmembrane transport	GO:0055085	412	0.024
nucleotide metabolic process	GO:0009117	332	0.024
aldehyde catabolic process	GO:0046185	4	0.024
reactive oxygen species metabolic process	GO:0072593	84	0.023
alcohol metabolic process	GO:0006066	116	0.022
spermatogenesis	GO:0007283	284	0.022
cellular modified amino acid metabolic process	GO:0006575	63	0.021
negative regulation of protein metabolic process	GO:0051248	282	0.021
nucleoside phosphate metabolic process	GO:0006753	338	0.021
protein catabolic process	GO:0030163	221	0.021
negative regulation of cellular protein metabolic process	GO:0032269	247	0.021
nitrogen compound transport	GO:0071705	271	0.021
cation transport	GO:0006812	399	0.021
apoptotic signaling pathway	GO:0097190	306	0.021
cation transmembrane transport	GO:0098655	266	0.020
carboxylic acid biosynthetic process	GO:0046394	86	0.020
purine containing compound metabolic process	GO:0072521	311	0.020
steroid metabolic process	GO:0008202	119	0.020
carbohydrate derivative biosynthetic process	GO:1901137	183	0.019
multicellular organismal signaling	GO:0035637	91	0.019
monocarboxylic acid metabolic process	GO:0032787	191	0.019
organic hydroxy compound transport	GO:0015850	93	0.019
heterocycle catabolic process	GO:0046700	280	0.019
cellular protein catabolic process	GO:0044257	155	0.018
transmission of nerve impulse	GO:0019226	76	0.018
regulation of hormone levels	GO:0010817	211	0.018
aromatic compound catabolic process	GO:0019439	286	0.018
organic cyclic compound catabolic process	GO:1901361	295	0.018
dna metabolic process	GO:0006259	303	0.018
regulation of organelle organization	GO:0033043	289	0.018
nuclear division	GO:0000280	158	0.018
posttranscriptional regulation of gene expression	GO:0010608	155	0.017
negative regulation of cellular amine metabolic process	GO:0033239	1	0.017
protein ubiquitination	GO:0016567	171	0.017
neuronal action potential	GO:0019228	54	0.017
embryonic organ morphogenesis	GO:0048562	276	0.017
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.017
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.016
mapk cascade	GO:0000165	281	0.016
response to organonitrogen compound	GO:0010243	246	0.016
action potential	GO:0001508	78	0.015
small molecule catabolic process	GO:0044282	71	0.015
regulation of transferase activity	GO:0051338	263	0.015
regulation of interleukin 8 production	GO:0032677	3	0.015
male gamete generation	GO:0048232	285	0.015
interleukin 8 production	GO:0032637	4	0.015
ion transmembrane transport	GO:0034220	361	0.015
modification dependent protein catabolic process	GO:0019941	133	0.015
negative regulation of protein modification process	GO:0031400	163	0.015
lateral inhibition	GO:0046331	1	0.015
cellular nitrogen compound catabolic process	GO:0044270	280	0.015
regulation of cell activation	GO:0050865	289	0.015
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.014
positive regulation of programmed cell death	GO:0043068	218	0.014
protein maturation	GO:0051604	176	0.014
renal system development	GO:0072001	225	0.014
regulation of protein localization	GO:0032880	231	0.014
positive regulation of protein modification process	GO:0031401	299	0.014
regulation of lymphocyte activation	GO:0051249	240	0.014
organic acid biosynthetic process	GO:0016053	86	0.014
skeletal system development	GO:0001501	356	0.014
l ascorbic acid metabolic process	GO:0019852	4	0.014
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.014
sensory organ morphogenesis	GO:0090596	242	0.014
cytokine production	GO:0001816	319	0.014
locomotory behavior	GO:0007626	195	0.014
positive regulation of apoptotic process	GO:0043065	217	0.014
cellular response to lipid	GO:0071396	145	0.014
fat cell differentiation	GO:0045444	160	0.014
sensory perception	GO:0007600	245	0.014
regulation of protein kinase activity	GO:0045859	232	0.013
reactive oxygen species biosynthetic process	GO:1903409	8	0.013
membrane organization	GO:0061024	245	0.013
cell type specific apoptotic process	GO:0097285	268	0.013
camera type eye development	GO:0043010	266	0.013
modification dependent macromolecule catabolic process	GO:0043632	133	0.013
response to organic cyclic compound	GO:0014070	198	0.013
negative regulation of cell proliferation	GO:0008285	296	0.013
protein processing	GO:0016485	163	0.013
purine nucleoside metabolic process	GO:0042278	241	0.013
negative regulation of phosphorylation	GO:0042326	166	0.013
positive regulation of interleukin 8 production	GO:0032757	2	0.013
hematopoietic progenitor cell differentiation	GO:0002244	143	0.013
regulation of defense response	GO:0031347	233	0.013
regulation of cytokine production	GO:0001817	266	0.013
organelle fission	GO:0048285	170	0.012
neuron death	GO:0070997	154	0.012
sulfur compound metabolic process	GO:0006790	100	0.012
ear development	GO:0043583	200	0.012
reactive nitrogen species metabolic process	GO:2001057	0	0.012
meiotic nuclear division	GO:0007126	115	0.012
proteasomal protein catabolic process	GO:0010498	98	0.012
coenzyme a biosynthetic process	GO:0015937	5	0.012
organophosphate biosynthetic process	GO:0090407	122	0.012
cellular response to organonitrogen compound	GO:0071417	145	0.012
protein modification by small protein conjugation	GO:0032446	187	0.012
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.012
plasma lipoprotein particle clearance	GO:0034381	13	0.012
purine nucleotide metabolic process	GO:0006163	302	0.012
cellular response to dna damage stimulus	GO:0006974	207	0.012
protein modification by small protein conjugation or removal	GO:0070647	207	0.012
negative regulation of protein phosphorylation	GO:0001933	126	0.012
synaptic transmission	GO:0007268	329	0.012
response to molecule of bacterial origin	GO:0002237	143	0.012
leukocyte differentiation	GO:0002521	342	0.012
bone development	GO:0060348	120	0.012
response to lipopolysaccharide	GO:0032496	128	0.011
positive regulation of cell death	GO:0010942	224	0.011
ribonucleoside metabolic process	GO:0009119	245	0.011
spermatid development	GO:0007286	108	0.011
inflammatory response	GO:0006954	244	0.011
regulation of mapk cascade	GO:0043408	248	0.011
skin development	GO:0043588	220	0.011
cellular aldehyde metabolic process	GO:0006081	12	0.011
germ cell development	GO:0007281	185	0.011
regulation of apoptotic signaling pathway	GO:2001233	197	0.011
chromatin organization	GO:0006325	206	0.011
kidney development	GO:0001822	213	0.011
inorganic cation transmembrane transport	GO:0098662	207	0.011
carbohydrate derivative catabolic process	GO:1901136	231	0.011
regulation of system process	GO:0044057	200	0.011
cellular response to biotic stimulus	GO:0071216	92	0.011
anatomical structure homeostasis	GO:0060249	145	0.011
ribose phosphate metabolic process	GO:0019693	291	0.011
intrinsic apoptotic signaling pathway	GO:0097193	132	0.011
response to acid chemical	GO:0001101	111	0.011
cellular amide metabolic process	GO:0043603	58	0.011
hormone metabolic process	GO:0042445	86	0.011
spermatid differentiation	GO:0048515	115	0.011
negative regulation of phosphate metabolic process	GO:0045936	184	0.011
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.011
immune effector process	GO:0002252	321	0.011
axon ensheathment	GO:0008366	76	0.011
monosaccharide metabolic process	GO:0005996	106	0.011
ubiquitin dependent protein catabolic process	GO:0006511	129	0.011
nucleoside catabolic process	GO:0009164	206	0.011
negative regulation of immune system process	GO:0002683	209	0.011
ensheathment of neurons	GO:0007272	76	0.010
nucleoside bisphosphate biosynthetic process	GO:0033866	6	0.010
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.010
regulation of cell cycle	GO:0051726	281	0.010
regulation of protein catabolic process	GO:0042176	108	0.010
negative regulation of intracellular signal transduction	GO:1902532	167	0.010
striated muscle tissue development	GO:0014706	293	0.010
cytoplasmic transport	GO:0016482	234	0.010
dephosphorylation	GO:0016311	129	0.010
glycoprotein biosynthetic process	GO:0009101	89	0.010
intracellular protein transport	GO:0006886	204	0.010
regulation of secretion	GO:0051046	274	0.010
microtubule based process	GO:0007017	236	0.010
glycosyl compound metabolic process	GO:1901657	246	0.010
circulatory system process	GO:0003013	197	0.010
cellular response to lipopolysaccharide	GO:0071222	77	0.010
organophosphate catabolic process	GO:0046434	232	0.010
ear morphogenesis	GO:0042471	118	0.010

Sil1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.040
disease of anatomical entity	DOID:7	0.040
disease of metabolism	DOID:0014667	0.034
sensory system disease	DOID:0050155	0.030
eye disease	DOID:5614	0.016
eye and adnexa disease	DOID:1492	0.016
inherited metabolic disorder	DOID:655	0.014
musculoskeletal system disease	DOID:17	0.012
connective tissue disease	DOID:65	0.012
central nervous system disease	DOID:331	0.011
neurodegenerative disease	DOID:1289	0.011
bone disease	DOID:0080001	0.011

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