Mus musculus

27 known processes

Ctsb

cathepsin B

(Aliases: CB)

Ctsb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of angiotensin levels in bloodGO:000200240.843
renin angiotensin regulation of aldosterone productionGO:000201830.740
natural killer cell degranulationGO:004332030.712
natural killer cell activation involved in immune responseGO:0002323100.698
ceramide metabolic processGO:0006672310.693
regulation of angiotensin metabolic processGO:006017740.638
peptide metabolic processGO:0006518460.636
vacuole organizationGO:0007033380.606
immune effector processGO:00022523210.558
cell killingGO:0001906670.447
male sex differentiationGO:00466611090.441
leukocyte mediated cytotoxicityGO:0001909620.431
membrane protein proteolysisGO:0033619100.428
leukocyte mediated immunityGO:00024431740.379
lymphocyte mediated immunityGO:00024491390.364
granzyme mediated apoptotic signaling pathwayGO:000862610.359
renal system processGO:0003014480.350
organelle assemblyGO:00709251770.333
extracellular matrix organizationGO:00301981470.333
positive regulation of leukocyte mediated cytotoxicityGO:0001912310.321
necrotic cell deathGO:0070265300.295
antigen processing and presentationGO:0019882470.282
apoptotic signaling pathwayGO:00971903060.266
male gonad developmentGO:0008584880.266
kidney developmentGO:00018222130.256
antigen processing and presentation of peptide antigenGO:0048002290.250
developmental maturationGO:00217001930.234
cellular response to hormone stimulusGO:00328701500.212
Human
renal system process involved in regulation of systemic arterial blood pressureGO:0003071150.204
protein processingGO:00164851630.202
regulation of cell killingGO:0031341400.198
development of primary sexual characteristicsGO:00451371430.194
renal system developmentGO:00720012250.182
antigen processing and presentation of exogenous peptide antigenGO:0002478210.177
gonad developmentGO:00084061410.171
regulation of systemic arterial blood pressureGO:0003073610.166
hormone metabolic processGO:0042445860.165
cellular amide metabolic processGO:0043603580.163
positive regulation of lymphocyte activationGO:00512511400.163
antigen processing and presentation of exogenous antigenGO:0019884260.159
positive regulation of apoptotic signaling pathwayGO:2001235950.152
regulation of epithelial cell proliferationGO:00506781410.148
glycosphingolipid catabolic processGO:004647950.137
development of primary male sexual characteristicsGO:0046546880.134
protein autoprocessingGO:001654020.132
epidermis developmentGO:00085441870.131
sphingolipid metabolic processGO:0006665450.131
microtubule based transportGO:0010970500.130
regulation of leukocyte mediated immunityGO:00027031040.130
regulation of systemic arterial blood pressure by circulatory renin angiotensinGO:0001991130.130
cellular component assembly involved in morphogenesisGO:00109271390.125
peptide hormone processingGO:001648690.122
carbohydrate derivative catabolic processGO:19011362310.121
lymphocyte activation involved in immune responseGO:0002285930.121
regulation of lymphocyte activationGO:00512492400.108
positive regulation of exocytosisGO:0045921200.108
oligosaccharide catabolic processGO:000931320.107
glycolipid metabolic processGO:0006664250.107
regulation of protein stabilityGO:0031647520.105
hormone mediated signaling pathwayGO:0009755230.102
cytoskeleton dependent intracellular transportGO:0030705500.101
positive regulation of natural killer cell mediated immunityGO:0002717160.101
autophagic vacuole assemblyGO:0000045130.099
positive regulation of response to woundingGO:1903036660.097
adaptive immune responseGO:00022501550.097
angiogenesisGO:00015252010.095
regulation of response to woundingGO:19030341890.093
maintenance of locationGO:0051235890.090
response to organic cyclic compoundGO:00140701980.090
Rat
response to extracellular stimulusGO:00099911270.088
regulation of hormone levelsGO:00108172110.082
mesonephros developmentGO:0001823970.078
negative regulation of response to oxidative stressGO:1902883100.078
cation homeostasisGO:00550802120.076
regulation of blood pressureGO:0008217930.074
protein maturationGO:00516041760.072
regulation of neuron apoptotic processGO:00435231220.072
regulation of apoptotic signaling pathwayGO:20012331970.071
positive regulation of inflammatory responseGO:0050729470.070
regulation of leukocyte mediated cytotoxicityGO:0001910380.068
sphingolipid catabolic processGO:003014970.068
regulation of response to oxidative stressGO:1902882190.068
regulation of systemic arterial blood pressure mediated by a chemical signalGO:0003044330.068
regulation of systemic arterial blood pressure by renin angiotensinGO:0003081200.067
regulation of cellular response to stressGO:00801351590.066
cellular homeostasisGO:00197252400.065
ceramide catabolic processGO:004651470.064
natural killer cell mediated immunityGO:0002228290.063
positive regulation of necrotic cell deathGO:001094010.062
inflammatory responseGO:00069542440.062
posttranscriptional regulation of gene expressionGO:00106081550.062
cell activation involved in immune responseGO:00022631260.062
antigen processing and presentation of peptide or polysaccharide antigen via mhc class iiGO:0002504170.061
regulation of lymphocyte mediated immunityGO:0002706840.061
regulation of peptidase activityGO:0052547960.060
endocrine processGO:0050886390.058
microtubule based processGO:00070172360.058
cellular chemical homeostasisGO:00550822150.057
positive regulation of innate immune responseGO:0045089800.057
glycolipid catabolic processGO:001937750.057
cell recognitionGO:0008037830.057
positive regulation of cell deathGO:00109422240.056
regulation of defense responseGO:00313472330.056
calcium ion transportGO:00068161590.055
regulation of proteolysisGO:00301621640.055
negative regulation of neuron deathGO:1901215980.054
cellular response to extracellular stimulusGO:0031668810.054
positive regulation of defense responseGO:00313491240.054
circulatory system processGO:00030131970.053
response to nutrient levelsGO:00316671090.052
antigen processing and presentation of exogenous peptide antigen via mhc class iiGO:0019886140.052
feeding behaviorGO:0007631620.051
i kappab kinase nf kappab signalingGO:0007249850.050
regulation of systemic arterial blood pressure by hormoneGO:0001990250.050
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.050
macroautophagyGO:0016236210.050
leukocyte degranulationGO:0043299270.050
response to oxidative stressGO:00069791230.049
small molecule catabolic processGO:0044282710.049
cellular response to nutrient levelsGO:0031669640.049
molting cycleGO:0042303900.047
cellular macromolecule catabolic processGO:00442652060.046
Human
extracellular structure organizationGO:00430621480.046
multicellular organismal agingGO:0010259240.046
Worm
male gamete generationGO:00482322850.045
Rat
regulation of blood volume by renin angiotensinGO:000201670.045
germ cell developmentGO:00072811850.045
membrane lipid catabolic processGO:004646680.045
lipid catabolic processGO:0016042690.045
ion transmembrane transportGO:00342203610.044
natural killer cell mediated cytotoxicityGO:0042267290.044
reactive oxygen species metabolic processGO:0072593840.043
phospholipid metabolic processGO:0006644870.042
divalent inorganic cation transportGO:00725111780.041
decidualizationGO:0046697100.041
cellular lipid catabolic processGO:0044242520.041
defense response to gram positive bacteriumGO:0050830500.041
regulation of secretionGO:00510462740.041
skeletal system developmentGO:00015013560.040
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.040
lipid storageGO:0019915360.039
positive regulation of programmed cell deathGO:00430682180.039
metal ion homeostasisGO:00550651890.039
regulation of natural killer cell activationGO:0032814220.039
positive regulation of natural killer cell mediated cytotoxicityGO:0045954160.038
keratinocyte proliferationGO:0043616210.037
regulation of phosphatidylcholine catabolic processGO:001089920.036
cation transportGO:00068123990.036
autophagyGO:0006914450.035
Rat
neuron apoptotic processGO:00514021420.035
sphingosine metabolic processGO:000667040.035
regulation of natural killer cell mediated immunityGO:0002715190.035
respiratory tube developmentGO:00303231670.035
sterol metabolic processGO:0016125580.034
leukocyte activation involved in immune responseGO:00023661260.033
transmission of nerve impulseGO:0019226760.032
antigen processing and presentation of peptide antigen via mhc class iiGO:0002495170.032
regulation of syncytium formation by plasma membrane fusionGO:0060142230.032
glycosylceramide metabolic processGO:000667740.031
lung morphogenesisGO:0060425500.031
t cell mediated cytotoxicityGO:0001913260.030
regulated secretory pathwayGO:0045055320.030
regulation of vesicle mediated transportGO:00606271390.030
sequestering of metal ionGO:0051238190.029
positive regulation of cell activationGO:00508671580.029
developmental growth involved in morphogenesisGO:00605601380.029
response to starvationGO:0042594650.029
muscle contractionGO:00069361010.029
cellular ion homeostasisGO:00068731650.028
spermatogenesisGO:00072832840.028
Rat
positive regulation of macroautophagyGO:001623930.028
protein stabilizationGO:0050821250.028
positive regulation of apoptotic processGO:00430652170.028
cytokine productionGO:00018163190.028
engulfment of apoptotic cellGO:004365230.028
positive regulation of immune effector processGO:00026991070.027
multi multicellular organism processGO:00447061090.027
t cell activationGO:00421102890.027
gland developmentGO:00487323300.027
protein catabolic processGO:00301632210.027
Human
morphogenesis of a branching structureGO:00017632030.026
neuronal action potentialGO:0019228540.026
blood circulationGO:00080151950.026
muscle cell differentiationGO:00426922610.026
macromolecule catabolic processGO:00090572810.025
Human
positive regulation of lymphocyte mediated immunityGO:0002708620.025
positive regulation of cell killingGO:0031343330.025
endocytosisGO:00068971680.025
Worm
regulation of cytokine productionGO:00018172660.025
leukocyte differentiationGO:00025213420.025
alcohol metabolic processGO:00060661160.025
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.025
regulation of membrane potentialGO:00423911920.024
regulation of microtubule based processGO:0032886520.024
glycoprotein metabolic processGO:00091001160.024
epithelial tube branching involved in lung morphogenesisGO:0060441280.024
cellular metal ion homeostasisGO:00068751510.024
regulation of system processGO:00440572000.024
organic hydroxy compound biosynthetic processGO:1901617770.024
l ascorbic acid metabolic processGO:001985240.024
lipid localizationGO:00108761260.024
anatomical structure maturationGO:0071695490.023
triglyceride metabolic processGO:0006641510.023
cell maturationGO:00484691270.023
response to molecule of bacterial originGO:00022371430.023
organic acid catabolic processGO:0016054510.023
regulation of leukocyte apoptotic processGO:2000106560.023
regulation of angiogenesisGO:0045765810.023
iron ion homeostasisGO:0055072360.023
regulation of cell activationGO:00508652890.022
cation transmembrane transportGO:00986552660.022
divalent metal ion transportGO:00708381720.022
cell adhesionGO:00071553290.022
negative regulation of keratinocyte proliferationGO:001083970.022
cell type specific apoptotic processGO:00972852680.022
organic acid transportGO:00158491010.022
protein lipid complex subunit organizationGO:0071825120.022
regulation of neuron deathGO:19012141340.022
cellular response to starvationGO:0009267570.022
t cell mediated immunityGO:0002456500.021
carbohydrate catabolic processGO:0016052320.021
production of molecular mediator of immune responseGO:00024401030.021
regulation of bindingGO:00510981110.021
multicellular organismal catabolic processGO:004424370.021
Human
vacuolar transportGO:0007034110.021
regulation of hemostasisGO:1900046280.021
respiratory system developmentGO:00605411900.021
glycerolipid metabolic processGO:00464861220.020
regulation of cell motilityGO:20001452360.020
oxidation reduction processGO:00551143420.020
transmembrane transportGO:00550854120.020
negative regulation of neuron apoptotic processGO:0043524920.020
hair cycleGO:0042633900.020
regulation of removal of superoxide radicalsGO:200012140.020
lysosomal transportGO:0007041100.020
regulation of erbb signaling pathwayGO:1901184160.019
sulfur compound metabolic processGO:00067901000.019
acetylcholine transportGO:001587020.019
response to monosaccharideGO:0034284670.019
Rat
nerve developmentGO:0021675670.019
regulation of cellular response to oxidative stressGO:1900407190.019
response to reactive oxygen speciesGO:0000302560.019
positive regulation of secretion by cellGO:19035321140.019
positive regulation of cellular amine metabolic processGO:003324050.019
homeostasis of number of cellsGO:00488722100.019
circadian sleep wake cycle rem sleepGO:004274710.019
regulation of endocytosisGO:0030100690.019
cholesterol metabolic processGO:0008203560.018
negative regulation of erbb signaling pathwayGO:190118570.018
response to steroid hormoneGO:0048545560.018
nucleotide metabolic processGO:00091173320.018
nucleoside phosphate metabolic processGO:00067533380.018
organic hydroxy compound metabolic processGO:19016152030.018
lipid modificationGO:0030258650.018
determination of left right symmetryGO:0007368800.018
regulation of regulated secretory pathwayGO:1903305200.018
prostate gland developmentGO:0030850480.018
regulation of immunological synapse formationGO:200052020.017
actin cytoskeleton organizationGO:00300362200.017
monocarboxylic acid transportGO:0015718440.017
establishment of planar polarityGO:0001736280.017
wound healingGO:00420601570.017
Zebrafish
liposaccharide metabolic processGO:1903509270.017
sterol transportGO:0015918380.017
positive regulation of mapk cascadeGO:00434101700.017
multicellular organismal signalingGO:0035637910.017
regulation of actin cytoskeleton organizationGO:0032956840.017
organic anion transportGO:00157111370.016
rho protein signal transductionGO:0007266320.016
fibrinolysisGO:004273030.016
multicellular organismal homeostasisGO:00488711640.016
morphogenesis of a branching epitheliumGO:00611381930.016
regulation of myeloid cell apoptotic processGO:0033032190.016
negative regulation of cell proliferationGO:00082852960.016
negative regulation of cellular response to oxidative stressGO:1900408100.016
cellular amino acid metabolic processGO:00065201030.016
positive regulation of chemotaxisGO:0050921380.016
lysosome organizationGO:0007040210.015
negative regulation of immune effector processGO:0002698550.015
cell cell recognitionGO:0009988440.015
amyloid precursor protein biosynthetic processGO:004298330.015
positive regulation of neutrophil apoptotic processGO:003303110.015
cellular protein catabolic processGO:00442571550.015
Human
neuromuscular process controlling balanceGO:0050885590.015
protein localization to vacuoleGO:007266540.015
lung developmentGO:00303241640.015
reactive oxygen species biosynthetic processGO:190340980.015
regulation of inflammatory responseGO:00507271470.015
muscle system processGO:00030121410.015
phospholipid transfer to membraneGO:000664920.015
water soluble vitamin biosynthetic processGO:004236430.015
camera type eye developmentGO:00430102660.015
superoxide metabolic processGO:0006801270.015
small molecule biosynthetic processGO:00442831320.014
female gamete generationGO:0007292740.014
small gtpase mediated signal transductionGO:0007264970.014
negative regulation of proteolysisGO:0045861740.014
muscle cell developmentGO:00550011330.014
alpha beta t cell activationGO:0046631910.014
cytoplasmic transportGO:00164822340.014
microtubule based movementGO:0007018840.014
cell chemotaxisGO:0060326810.014
regulation of keratinocyte proliferationGO:0010837150.014
positive regulation of membrane protein ectodomain proteolysisGO:005104430.014
catagenGO:004263750.014
regulation of protein catabolic processGO:00421761080.014
negative regulation of platelet derived growth factor receptor alpha signaling pathwayGO:200058420.014
positive regulation of endocytosisGO:0045807420.014
striated muscle cell developmentGO:00550021250.014
glycerolipid catabolic processGO:0046503160.013
eosinophil migrationGO:007267730.013
forebrain radial glial cell differentiationGO:002186140.013
sertoli cell differentiationGO:0060008180.013
heterocycle catabolic processGO:00467002800.013
sensory system developmentGO:004888030.013
regulation of natural killer cell mediated cytotoxicityGO:0042269190.013
negative regulation of epithelial cell proliferationGO:0050680640.013
defense response to bacteriumGO:00427421190.013
maternal process involved in female pregnancyGO:0060135320.013
response to lipopolysaccharideGO:00324961280.013
aromatic compound catabolic processGO:00194392860.013
hair cycle phaseGO:0044851160.013
ceramide biosynthetic processGO:0046513200.013
blood vessel morphogenesisGO:00485142850.013
positive regulation of homeostatic processGO:0032846640.013
cellular lipid metabolic processGO:00442553230.013
cellular response to acid chemicalGO:0071229680.013
cellular response to oxidative stressGO:0034599760.013
lipid transportGO:0006869980.013
regulation of body fluid levelsGO:00508781620.013
organ growthGO:00352651170.013
regulation of transferase activityGO:00513382630.013
myelinationGO:0042552740.013
lateral line system developmentGO:004892510.013
regulation of adaptive immune responseGO:0002819900.013
notochord cell differentiationGO:006003410.012
intracellular sterol transportGO:003236630.012
regulation of wnt signaling pathwayGO:00301111230.012
positive regulation of nervous system developmentGO:00519622210.012
positive regulation of leukocyte mediated immunityGO:0002705700.012
positive regulation of cellular amino acid metabolic processGO:004576430.012
regulation of protein transportGO:00512231630.012
response to acid chemicalGO:00011011110.012
regulation of leukocyte degranulationGO:0043300200.012
lymphocyte costimulationGO:0031294150.012
single fertilizationGO:0007338820.012
nucleobase containing small molecule metabolic processGO:00550863520.012
skin developmentGO:00435882200.012
blood coagulationGO:0007596760.012
extrinsic apoptotic signaling pathway via death domain receptorsGO:0008625340.012
positive regulation of eosinophil migrationGO:200041820.012
fertilizationGO:00095661270.012
action potentialGO:0001508780.012
natural killer cell activationGO:0030101440.012
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.011
cellular response to organonitrogen compoundGO:00714171450.011
defense response to other organismGO:00985421970.011
carbohydrate derivative biosynthetic processGO:19011371830.011
carboxylic acid transportGO:00469421000.011
protein oligomerizationGO:0051259670.011
neuron projection regenerationGO:0031102140.011
cellular response to hydroperoxideGO:007144740.011
glycosaminoglycan metabolic processGO:0030203340.011
tissue homeostasisGO:00018941150.011
adult locomotory behaviorGO:0008344910.011
urogenital system developmentGO:00016552610.011
myosin filament organizationGO:003103330.011
cellular ketone metabolic processGO:0042180840.011
positive regulation of regulated secretory pathwayGO:1903307100.011
skin morphogenesisGO:0043589380.011
organonitrogen compound catabolic processGO:19015652640.011
carbohydrate homeostasisGO:00335001280.011
regulation of intracellular transportGO:00323861590.011
regulation of cytoskeleton organizationGO:00514931220.011
meiotic nuclear divisionGO:00071261150.011
leukocyte chemotaxisGO:0030595690.010
negative regulation of apoptotic signaling pathwayGO:20012341040.010
regulation of cellular amine metabolic processGO:0033238200.010
fat soluble vitamin biosynthetic processGO:004236240.010
myosin filament assemblyGO:003103420.010
learning or memoryGO:00076111480.010
thymocyte migrationGO:007267920.010
lateral inhibitionGO:004633110.010
positive regulation of leukocyte degranulationGO:0043302100.010
myeloid leukocyte migrationGO:0097529570.010
negative regulation of intracellular signal transductionGO:19025321670.010
bone developmentGO:00603481200.010
negative regulation of vesicle fusionGO:003133910.010
epithelial cell proliferationGO:00506731740.010
blastocyst developmentGO:0001824800.010
t cell activation involved in immune responseGO:0002286430.010
establishment of vesicle localizationGO:0051650810.010
striated muscle tissue developmentGO:00147062930.010
Rat
plasma cell differentiationGO:000231730.010
anatomical structure homeostasisGO:00602491450.010
regulation of exocytosisGO:0017157610.010

Ctsb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
lysosomal storage diseaseDOID:321100.993
disease of metabolismDOID:001466700.993
inherited metabolic disorderDOID:65500.993
lipid storage diseaseDOID:945500.972
central nervous system diseaseDOID:33100.702
nervous system diseaseDOID:86300.702
disease of anatomical entityDOID:700.702
sphingolipidosisDOID:192700.576
brain diseaseDOID:93600.335
neuronal ceroid lipofuscinosisDOID:1450300.231
cerebral degenerationDOID:144300.172
charcot marie tooth diseaseDOID:1059500.047
neuropathyDOID:87000.047
neuromuscular diseaseDOID:44000.047
immune system diseaseDOID:291400.033
lymphatic system diseaseDOID:7500.031
electroclinical syndromeDOID:005070100.027
epilepsy syndromeDOID:182600.027
retinal diseaseDOID:567900.027
eye diseaseDOID:561400.027
retinal degenerationDOID:846600.027
sensory system diseaseDOID:005015500.027
eye and adnexa diseaseDOID:149200.027
cognitive disorderDOID:156100.020
disease of mental healthDOID:15000.020
variable age at onset electroclinical syndromeDOID:005070600.018
acquired metabolic diseaseDOID:006015800.018
progressive myoclonus epilepsyDOID:89100.016
musculoskeletal system diseaseDOID:1700.012
connective tissue diseaseDOID:6500.012