Mus musculus

27 known processes

Ctsz

cathepsin Z

(Aliases: CTSX,AI787083,D2Wsu143e,AU019819)

Ctsz biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
sphingolipid catabolic processGO:003014970.445
leukocyte mediated cytotoxicityGO:0001909620.300
Mouse
ceramide metabolic processGO:0006672310.238
vacuole organizationGO:0007033380.211
glycosphingolipid catabolic processGO:004647950.169
sphingolipid metabolic processGO:0006665450.142
antigen processing and presentationGO:0019882470.134
cation homeostasisGO:00550802120.132
regulation of actin cytoskeleton organizationGO:0032956840.125
cytokine productionGO:00018163190.115
regulation of neuron apoptotic processGO:00435231220.113
sphingoid metabolic processGO:004651950.100
male gamete generationGO:00482322850.100
circulatory system processGO:00030131970.100
ceramide biosynthetic processGO:0046513200.097
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.096
Mouse
lysosome organizationGO:0007040210.096
cellular response to thyroid hormone stimulusGO:009706710.095
carbohydrate metabolic processGO:00059752300.095
antigen processing and presentation of exogenous antigenGO:0019884260.094
carbohydrate derivative catabolic processGO:19011362310.093
sphingosine metabolic processGO:000667040.089
adaptive immune responseGO:00022501550.089
Mouse
lymphocyte mediated immunityGO:00024491390.078
Mouse
regulation of epithelial cell proliferationGO:00506781410.077
lytic vacuole organizationGO:0080171210.075
positive regulation of interleukin 1 alpha productionGO:003273040.073
regulation of peptidase activityGO:0052547960.070
Mouse
glycolipid catabolic processGO:001937750.069
positive regulation of apoptotic signaling pathwayGO:2001235950.068
Mouse
glycolipid metabolic processGO:0006664250.066
cell type specific apoptotic processGO:00972852680.065
leukocyte mediated immunityGO:00024431740.064
Mouse
multicellular organism growthGO:00352641610.061
sensory perception of soundGO:0007605970.061
regulation of hydrolase activityGO:00513362460.061
Mouse
response to lipopolysaccharideGO:00324961280.060
regulation of interleukin 1 alpha productionGO:003265040.059
angiogenesisGO:00015252010.058
Zebrafish
sequestering of metal ionGO:0051238190.057
t cell activationGO:00421102890.057
metal ion homeostasisGO:00550651890.057
immune effector processGO:00022523210.057
Mouse
oxidation reduction processGO:00551143420.056
oligosaccharide catabolic processGO:000931320.056
male sex differentiationGO:00466611090.055
organic anion transportGO:00157111370.055
lipid transportGO:0006869980.055
membrane lipid catabolic processGO:004646680.055
neuromuscular process controlling balanceGO:0050885590.053
cellular homeostasisGO:00197252400.053
renal system processGO:0003014480.053
cation transportGO:00068123990.051
regulation of systemic arterial blood pressure by carotid body chemoreceptor signalingGO:000302710.049
reactive oxygen species biosynthetic processGO:190340980.048
carbohydrate catabolic processGO:0016052320.048
t cell mediated immunityGO:0002456500.047
Mouse
phagolysosome assemblyGO:000184530.046
divalent metal ion transportGO:00708381720.046
cellular response to hormone stimulusGO:00328701500.045
regulation of secretionGO:00510462740.045
inflammatory responseGO:00069542440.044
regulation of blood pressureGO:0008217930.044
neuron deathGO:00709971540.043
regulation of apoptotic signaling pathwayGO:20012331970.042
Mouse
divalent inorganic cation transportGO:00725111780.042
positive regulation of t cell mediated cytotoxicityGO:0001916150.042
cellular ion homeostasisGO:00068731650.042
negative regulation of cell proliferationGO:00082852960.042
regulation of membrane potentialGO:00423911920.041
antigen processing and presentation of peptide antigenGO:0048002290.041
vesicle organizationGO:0016050600.041
endocytosisGO:00068971680.041
maintenance of locationGO:0051235890.041
neuromuscular processGO:0050905990.040
regulation of cytokine productionGO:00018172660.039
calcium ion transportGO:00068161590.038
renal system developmentGO:00720012250.038
membrane lipid biosynthetic processGO:0046467320.037
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.037
negative regulation of cellular protein metabolic processGO:00322692470.037
reactive nitrogen species metabolic processGO:200105700.037
apoptotic signaling pathwayGO:00971903060.037
Mouse
cellular response to external stimulusGO:0071496880.037
purinergic nucleotide receptor signaling pathwayGO:003559030.037
regulation of cellular amine metabolic processGO:0033238200.037
multicellular organismal homeostasisGO:00488711640.037
ion transmembrane transportGO:00342203610.036
regulation of t cell activationGO:00508631700.036
negative regulation of neuron deathGO:1901215980.035
regulation of protein transportGO:00512231630.035
posttranscriptional regulation of gene expressionGO:00106081550.035
membrane lipid metabolic processGO:0006643530.035
neuronal action potentialGO:0019228540.034
skeletal system developmentGO:00015013560.034
multicellular organismal metabolic processGO:0044236280.034
cellular ketone metabolic processGO:0042180840.034
transmission of nerve impulseGO:0019226760.034
reactive oxygen species metabolic processGO:0072593840.034
organonitrogen compound catabolic processGO:19015652640.034
carboxylic acid transportGO:00469421000.033
neuron apoptotic processGO:00514021420.033
cellular lipid metabolic processGO:00442553230.033
defense response to other organismGO:00985421970.033
anion transportGO:00068201770.032
cellular chemical homeostasisGO:00550822150.032
lymphocyte activation involved in immune responseGO:0002285930.032
fat cell differentiationGO:00454441600.031
regulation of proteolysisGO:00301621640.031
Mouse
organic hydroxy compound metabolic processGO:19016152030.031
amine metabolic processGO:0009308450.031
multicellular organismal macromolecule metabolic processGO:0044259190.031
response to nutrient levelsGO:00316671090.031
innate immune responseGO:00450871570.031
regulation of vascular smooth muscle contractionGO:000305610.030
negative regulation of proteolysisGO:0045861740.030
cellular macromolecule catabolic processGO:00442652060.030
lymphocyte homeostasisGO:0002260640.030
lymphocyte proliferationGO:00466511640.030
response to molecule of bacterial originGO:00022371430.029
regulation of endopeptidase activityGO:0052548890.029
proteolysis involved in cellular protein catabolic processGO:00516031470.029
monocarboxylic acid metabolic processGO:00327871910.029
cellular amino acid metabolic processGO:00065201030.029
interspecies interaction between organismsGO:0044419830.029
organic acid transportGO:00158491010.028
regulation of lymphocyte activationGO:00512492400.028
multi multicellular organism processGO:00447061090.028
epithelial cell proliferationGO:00506731740.028
cellular divalent inorganic cation homeostasisGO:00725031270.028
cellular amine metabolic processGO:0044106440.027
arp2 3 complex mediated actin nucleationGO:003431430.027
t cell homeostasisGO:0043029350.027
hexose metabolic processGO:0019318980.027
engulfment of apoptotic cellGO:004365230.027
regulation of protein localizationGO:00328802310.027
tissue homeostasisGO:00018941150.027
vasodilationGO:0042311280.026
cellular lipid catabolic processGO:0044242520.026
glycosylceramide metabolic processGO:000667740.026
extracellular matrix organizationGO:00301981470.026
phospholipid transfer to membraneGO:000664920.025
positive regulation of cellular amine metabolic processGO:003324050.025
cellular protein catabolic processGO:00442571550.025
protein oligomerizationGO:0051259670.025
regulation of protein stabilityGO:0031647520.025
macromolecule catabolic processGO:00090572810.025
negative regulation of endoplasmic reticulum calcium ion concentrationGO:003247130.024
spermatogenesisGO:00072832840.024
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002824610.024
aromatic compound catabolic processGO:00194392860.024
defense response to bacteriumGO:00427421190.024
leukocyte proliferationGO:00706611720.023
positive regulation of immune effector processGO:00026991070.023
male gonad developmentGO:0008584880.023
leukocyte homeostasisGO:0001776790.023
nuclear membrane organizationGO:007176340.023
striated muscle tissue developmentGO:00147062930.023
immunoglobulin mediated immune responseGO:0016064690.023
epithelial tube branching involved in lung morphogenesisGO:0060441280.023
cellular metal ion homeostasisGO:00068751510.022
developmental maturationGO:00217001930.022
monosaccharide metabolic processGO:00059961060.022
purine containing compound catabolic processGO:00725232130.022
negative regulation of neuron apoptotic processGO:0043524920.022
fertilizationGO:00095661270.022
membrane organizationGO:00610242450.022
phagosome maturationGO:009038240.022
lateral inhibitionGO:004633110.021
glycoprotein metabolic processGO:00091001160.021
anatomical structure homeostasisGO:00602491450.021
extracellular structure organizationGO:00430621480.021
regulation of leukocyte mediated immunityGO:00027031040.021
regulation of cellular catabolic processGO:00313292420.021
sequestering of calcium ionGO:0051208180.021
glycosyl compound catabolic processGO:19016582060.021
leukocyte apoptotic processGO:0071887710.021
action potentialGO:0001508780.021
endomembrane system organizationGO:00102561470.021
regulation of ossificationGO:00302781120.021
regulation of establishment of protein localizationGO:00702011810.020
regulation of gamma aminobutyric acid secretionGO:001405220.020
negative regulation of vesicle fusionGO:003133910.020
axonogenesisGO:00074092740.020
lipid storageGO:0019915360.020
negative regulation of cell activationGO:00508661110.020
liposaccharide metabolic processGO:1903509270.020
regulation of system processGO:00440572000.020
membrane protein proteolysisGO:0033619100.020
regulation of cytokine secretionGO:0050707610.020
positive regulation of cellular component biogenesisGO:0044089940.020
regulation of cellular component biogenesisGO:00440871810.020
regulation of reactive oxygen species metabolic processGO:2000377400.019
response to extracellular stimulusGO:00099911270.019
regulation of interleukin 1 alpha secretionGO:005070530.019
regulation of t cell mediated immunityGO:0002709340.019
epidermis developmentGO:00085441870.019
regulation of cellular amino acid metabolic processGO:000652150.019
regulation of arp2 3 complex mediated actin nucleationGO:003431510.019
neuron projection guidanceGO:00974851410.019
monocarboxylic acid catabolic processGO:0072329270.019
hair cycleGO:0042633900.019
regulation of anatomical structure sizeGO:00900661780.019
long chain fatty acid transportGO:0015909150.019
maternal process involved in female pregnancyGO:0060135320.018
organelle assemblyGO:00709251770.018
negative regulation of protein metabolic processGO:00512482820.018
hormone metabolic processGO:0042445860.018
response to interleukin 4GO:0070670230.018
positive regulation of ossificationGO:0045778470.018
regulation of body fluid levelsGO:00508781620.018
t cell mediated cytotoxicityGO:0001913260.018
Mouse
protein catabolic processGO:00301632210.018
positive regulation of t cell mediated immunityGO:0002711240.018
superoxide metabolic processGO:0006801270.018
cytoplasmic transportGO:00164822340.018
iron ion homeostasisGO:0055072360.018
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.018
ceramide catabolic processGO:004651470.018
cytokine secretionGO:0050663720.018
myelinationGO:0042552740.018
multicellular organismal catabolic processGO:004424370.018
negative regulation of fibroblast proliferationGO:0048147140.018
carboxylic acid catabolic processGO:0046395510.018
regulation of leukocyte proliferationGO:00706631210.018
regulation of lymphocyte mediated immunityGO:0002706840.017
positive regulation of vasodilationGO:004590930.017
skeletal muscle organ developmentGO:00605381630.017
actin filament polymerizationGO:0030041440.017
protein processingGO:00164851630.017
muscle tissue developmentGO:00605373080.017
astrocyte cell migrationGO:004361530.017
organic acid catabolic processGO:0016054510.017
muscle cell differentiationGO:00426922610.017
leukocyte differentiationGO:00025213420.017
skin developmentGO:00435882200.017
protein autoprocessingGO:001654020.017
response to organic cyclic compoundGO:00140701980.017
positive regulation of cytokine productionGO:00018191740.017
regulation of adaptive immune responseGO:0002819900.017
erbb signaling pathwayGO:0038127320.017
cellular response to dna damage stimulusGO:00069742070.017
lung morphogenesisGO:0060425500.017
carbohydrate derivative biosynthetic processGO:19011371830.017
urogenital system developmentGO:00016552610.017
transmembrane transportGO:00550854120.017
cell adhesionGO:00071553290.017
regulation of cell activationGO:00508652890.017
ossificationGO:00015032160.016
glycosphingolipid metabolic processGO:0006687180.016
homeostasis of number of cellsGO:00488722100.016
regulation of tube sizeGO:0035150570.016
vascular process in circulatory systemGO:0003018620.016
interleukin 1 alpha secretionGO:005070330.016
protein secretionGO:00093061110.016
placenta developmentGO:00018901400.016
amino acid transportGO:0006865610.016
sensory system developmentGO:004888030.016
cellular response to nutrient levelsGO:0031669640.016
multicellular organismal signalingGO:0035637910.016
regulation of vesicle mediated transportGO:00606271390.016
muscle fiber developmentGO:0048747760.016
response to monosaccharideGO:0034284670.016
negative regulation of blood pressureGO:0045776220.016
regulation of cytoskeleton organizationGO:00514931220.015
protein localization to organelleGO:00333651850.015
nucleobase containing small molecule metabolic processGO:00550863520.015
negative regulation of intracellular signal transductionGO:19025321670.015
carbohydrate biosynthetic processGO:0016051740.015
regulation of protein serine threonine kinase activityGO:00719001570.015
interleukin 8 secretionGO:007260630.015
dephosphorylationGO:00163111290.015
nitrogen compound transportGO:00717052710.015
wound healingGO:00420601570.015
mesonephros developmentGO:0001823970.015
purine ribonucleotide catabolic processGO:00091542080.015
positive regulation of secretion by cellGO:19035321140.015
development of primary male sexual characteristicsGO:0046546880.015
response to organonitrogen compoundGO:00102432460.015
chemotaxisGO:00069352470.015
positive regulation of cell activationGO:00508671580.015
ear developmentGO:00435832000.015
i kappab kinase nf kappab signalingGO:0007249850.014
negative regulation of lymphocyte activationGO:0051250910.014
cellular response to cytokine stimulusGO:00713451890.014
cell recognitionGO:0008037830.014
small molecule catabolic processGO:0044282710.014
cellular nitrogen compound catabolic processGO:00442702800.014
regulation of protein secretionGO:0050708820.014
heterocycle catabolic processGO:00467002800.014
antigen processing and presentation of exogenous peptide antigenGO:0002478210.014
positive regulation of secretionGO:00510471300.014
regulation of blood vessel sizeGO:0050880560.014
regulation of cell shapeGO:0008360390.014
cellular calcium ion homeostasisGO:00068741190.014
bone developmentGO:00603481200.014
regulation of secretion by cellGO:19035302490.014
positive regulation of lymphocyte activationGO:00512511400.014
response to drugGO:0042493750.014
g1 s transition of mitotic cell cycleGO:0000082570.014
camera type eye developmentGO:00430102660.014
epithelium migrationGO:0090132630.014
peptide transportGO:00158331330.014
muscle contractionGO:00069361010.014
regulation of cellular ketone metabolic processGO:0010565660.014
intrinsic apoptotic signaling pathway in response to dna damageGO:0008630570.013
cellularizationGO:000734910.013
protein maturationGO:00516041760.013
negative regulation of cellular component organizationGO:00511291940.013
respiratory burstGO:004573080.013
biomineral tissue developmentGO:0031214640.013
collagen metabolic processGO:0032963170.013
cofactor transportGO:005118140.013
regulation of immunological synapse formationGO:200052020.013
respiratory tube developmentGO:00303231670.013
regulation of homeostatic processGO:00328441820.013
kidney developmentGO:00018222130.013
regulation of angiogenesisGO:0045765810.013
blood coagulationGO:0007596760.013
negative regulation of osteoblast proliferationGO:003368940.013
regulation of interleukin 6 productionGO:0032675550.013
regulation of inflammatory responseGO:00507271470.013
organism emergence from protective structureGO:007168440.013
response to nerve growth factorGO:199008930.013
positive regulation of epithelial cell proliferationGO:0050679680.013
protein localization to vacuoleGO:007266540.013
protein localization to cell leading edgeGO:190246310.013
regulation of metal ion transportGO:00109591060.013
regulation of cell motilityGO:20001452360.013
positive regulation of cell deathGO:00109422240.013
Mouse
homeostasis of number of cells within a tissueGO:0048873250.013
lateral line system developmentGO:004892510.012
interleukin 1 beta productionGO:0032611300.012
sterol homeostasisGO:0055092450.012
ribonucleoside catabolic processGO:00424542060.012
sensory perceptionGO:00076002450.012
metanephros developmentGO:0001656790.012
plasma cell differentiationGO:000231730.012
purine containing compound metabolic processGO:00725213110.012
establishment of organelle localizationGO:00516561220.012
blood vessel morphogenesisGO:00485142850.012
Zebrafish
exocytosisGO:00068871210.012
regulation of fibroblast proliferationGO:0048145340.012
lipid catabolic processGO:0016042690.012
regulation of lymphocyte proliferationGO:00506701170.012
cell killingGO:0001906670.012
Mouse
negative regulation of cytokine productionGO:0001818840.012
bone mineralizationGO:0030282540.012
antigen receptor mediated signaling pathwayGO:0050851640.012
positive regulation of endopeptidase activityGO:0010950430.012
glycosaminoglycan metabolic processGO:0030203340.012
defense response to gram positive bacteriumGO:0050830500.012
negative regulation of protein maturationGO:1903318790.012
negative regulation of defense responseGO:0031348770.012
cellular response to lipopolysaccharideGO:0071222770.012
organophosphate catabolic processGO:00464342320.012
rhythmic processGO:00485111740.012
regulation of cell migrationGO:00303342190.012
positive regulation of proteolysisGO:0045862850.011
Mouse
inorganic ion transmembrane transportGO:00986602340.011
regulation of interleukin 8 productionGO:003267730.011
cell activation involved in immune responseGO:00022631260.011
sulfur compound metabolic processGO:00067901000.011
membrane depolarizationGO:0051899640.011
myotube differentiationGO:00149021050.011
determination of left right symmetryGO:0007368800.011
aminoglycan metabolic processGO:0006022340.011
sensory organ morphogenesisGO:00905962420.011
response to inorganic substanceGO:0010035960.011
transition metal ion transportGO:0000041380.011
lipid biosynthetic processGO:00086101790.011
cellular response to molecule of bacterial originGO:0071219830.011
regulation of glutamate secretionGO:001404830.011
establishment of protein localization to vacuoleGO:007266640.011
nucleoside metabolic processGO:00091162460.011
lymphocyte apoptotic processGO:0070227540.011
small molecule biosynthetic processGO:00442831320.011
purine ribonucleoside catabolic processGO:00461302050.011
glial cell apoptotic processGO:003434930.011
calcium ion homeostasisGO:00550741270.011
regulation of t cell mediated cytotoxicityGO:0001914180.011
uropod organizationGO:003279620.011
response to starvationGO:0042594650.011
protein homooligomerizationGO:0051260430.011
blood circulationGO:00080151950.011
ribonucleotide metabolic processGO:00092592910.010
positive regulation of t cell proliferationGO:0042102520.010
response to iron ionGO:001003940.010
amide transportGO:00428861380.010
purine nucleoside catabolic processGO:00061522050.010
negative regulation of response to woundingGO:1903035770.010
positive regulation of leukocyte mediated cytotoxicityGO:0001912310.010
immune response in mucosal associated lymphoid tissueGO:000238620.010
regulation of hormone levelsGO:00108172110.010
epidermis morphogenesisGO:0048730330.010
positive regulation of homeostatic processGO:0032846640.010
nerve developmentGO:0021675670.010
notch signaling pathwayGO:0007219710.010
ribonucleoside metabolic processGO:00091192450.010
establishment of protein localization to organelleGO:00725941180.010
positive regulation of actin filament polymerizationGO:0030838260.010
regulation of protein maturationGO:1903317960.010
endothelial cell chemotaxisGO:003576730.010
negative regulation of transcription factor import into nucleusGO:0042992130.010
mitotic cell cycleGO:00002781950.010
nucleoside triphosphate metabolic processGO:00091412300.010
positive regulation of amino acid transportGO:005195740.010
hair follicle morphogenesisGO:0031069290.010

Ctsz disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
inherited metabolic disorderDOID:65500.800
disease of metabolismDOID:001466700.800
lysosomal storage diseaseDOID:321100.457
sphingolipidosisDOID:192700.457
lipid storage diseaseDOID:945500.457
brain diseaseDOID:93600.371
nervous system diseaseDOID:86300.371
disease of anatomical entityDOID:700.371
central nervous system diseaseDOID:33100.371
immune system diseaseDOID:291400.103
cerebral degenerationDOID:144300.071
neuromuscular diseaseDOID:44000.041
charcot marie tooth diseaseDOID:1059500.041
neuropathyDOID:87000.041
electroclinical syndromeDOID:005070100.034
epilepsy syndromeDOID:182600.034
primary immunodeficiency diseaseDOID:61200.023
variable age at onset electroclinical syndromeDOID:005070600.015
progressive myoclonus epilepsyDOID:89100.013
lymphatic system diseaseDOID:7500.012
connective tissue diseaseDOID:6500.011
musculoskeletal system diseaseDOID:1700.011
neuronal ceroid lipofuscinosisDOID:1450300.010