Mus musculus

95 known processes

Rpe65

retinal pigment epithelium 65

(Aliases: rd12,LCA2,A930029L06Rik,65kDa,RP20,Mord1)

Rpe65 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
rhodopsin mediated signaling pathwayGO:001605640.741
phototransductionGO:0007602170.702
Fly
cellular lipid metabolic processGO:00442553230.267
inflammatory responseGO:00069542440.258
positive regulation of kinase activityGO:00336741550.199
cellular ketone metabolic processGO:0042180840.183
activation of immune responseGO:00022531380.183
metencephalon developmentGO:0022037890.156
negative regulation of defense responseGO:0031348770.149
detection of stimulusGO:0051606840.148
Fly
regulation of response to woundingGO:19030341890.147
regulation of cellular ketone metabolic processGO:0010565660.146
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.144
regulation of lipid metabolic processGO:00192161180.139
vitamin a metabolic processGO:000677620.132
Fly
regulation of transferase activityGO:00513382630.131
regulation of feeding behaviorGO:006025930.128
regulation of kinase activityGO:00435492490.119
i kappab kinase nf kappab signalingGO:0007249850.111
detection of light stimulusGO:0009583250.111
Fly
regulation of protein serine threonine kinase activityGO:00719001570.108
positive regulation of protein kinase activityGO:00458601440.106
hexose metabolic processGO:0019318980.105
terpenoid metabolic processGO:0006721250.103
oxidation reduction processGO:00551143420.102
Mouse Fly
negative regulation of protein phosphorylationGO:00019331260.102
adaptive immune responseGO:00022501550.098
mapk cascadeGO:00001652810.097
monocarboxylic acid metabolic processGO:00327871910.097
positive regulation of transferase activityGO:00513471670.094
b cell mediated immunityGO:0019724710.090
g protein coupled receptor signaling pathwayGO:00071862430.088
negative regulation of platelet derived growth factor receptor signaling pathwayGO:001064270.087
fatty acid metabolic processGO:00066311210.086
cellular response to light stimulusGO:0071482190.081
Fly
phototransduction visible lightGO:000760360.078
Fly
response to radiationGO:00093141650.074
Fly
cellular response to insulin stimulusGO:0032869780.073
negative regulation of molecular functionGO:00440922580.072
response to drugGO:0042493750.072
fertilizationGO:00095661270.069
detection of visible lightGO:0009584140.068
Fly
cellular response to hormone stimulusGO:00328701500.068
transmission of nerve impulseGO:0019226760.068
glucose metabolic processGO:0006006920.068
regulation of multi organism processGO:00439001110.067
negative regulation of intracellular signal transductionGO:19025321670.067
lymphocyte mediated immunityGO:00024491390.066
cation transportGO:00068123990.066
cellular carbohydrate metabolic processGO:00442621190.065
cerebellum developmentGO:0021549770.063
striated muscle tissue developmentGO:00147062930.062
hindbrain morphogenesisGO:0021575460.062
humoral immune responseGO:0006959570.061
macromolecule catabolic processGO:00090572810.060
response to peptideGO:19016521360.060
immunoglobulin mediated immune responseGO:0016064690.059
negative regulation of phosphate metabolic processGO:00459361840.059
response to organonitrogen compoundGO:00102432460.058
response to organic cyclic compoundGO:00140701980.058
sensory perceptionGO:00076002450.057
carbohydrate transportGO:0008643620.056
isoprenoid metabolic processGO:0006720290.056
regulation of map kinase activityGO:00434051200.055
regulation of protein kinase activityGO:00458592320.054
photoreceptor cell developmentGO:0042461400.054
carbohydrate biosynthetic processGO:0016051740.053
camera type eye developmentGO:00430102660.052
regulation of cell migrationGO:00303342190.052
carbohydrate homeostasisGO:00335001280.051
regulation of platelet derived growth factor receptor alpha signaling pathwayGO:200058320.049
positive regulation of protein serine threonine kinase activityGO:00719021060.049
negative regulation of map kinase activityGO:0043407340.048
amine metabolic processGO:0009308450.048
negative regulation of response to woundingGO:1903035770.047
synaptic transmissionGO:00072683290.047
negative regulation of cellular protein metabolic processGO:00322692470.047
regulation of glomerulus developmentGO:009019260.047
negative regulation of inflammatory responseGO:0050728610.047
response to monosaccharideGO:0034284670.046
cellular response to organonitrogen compoundGO:00714171450.045
regulation of defense responseGO:00313472330.045
negative regulation of phosphorus metabolic processGO:00105631840.045
positive regulation of protein modification processGO:00314012990.045
protein processingGO:00164851630.044
protein catabolic processGO:00301632210.044
organonitrogen compound biosynthetic processGO:19015661920.044
ion transmembrane transportGO:00342203610.044
regulation of system processGO:00440572000.044
negative regulation of protein metabolic processGO:00512482820.044
retina development in camera type eyeGO:00600411190.043
organic anion transportGO:00157111370.042
anatomical structure homeostasisGO:00602491450.042
response to insulinGO:00328681000.042
regulation of inflammatory responseGO:00507271470.041
glucose homeostasisGO:00425931280.041
protein activation cascadeGO:0072376190.041
regulation of cellular amino acid metabolic processGO:000652150.041
leukocyte mediated immunityGO:00024431740.040
single fertilizationGO:0007338820.040
positive regulation of cell developmentGO:00107202370.039
neuronal action potentialGO:0019228540.039
action potentialGO:0001508780.039
fat soluble vitamin metabolic processGO:0006775110.039
Fly
negative regulation of protein serine threonine kinase activityGO:0071901490.039
cellular response to peptideGO:1901653920.039
cerebellar cortex developmentGO:0021695480.039
carbohydrate metabolic processGO:00059752300.038
urogenital system developmentGO:00016552610.038
protein secretionGO:00093061110.038
complement activationGO:0006956160.037
regulation of glucose metabolic processGO:0010906600.037
purine ribonucleotide metabolic processGO:00091502900.037
binding of sperm to zona pellucidaGO:0007339340.036
photoreceptor cell differentiationGO:0046530520.036
negative regulation of mapk cascadeGO:0043409650.036
cation homeostasisGO:00550802120.036
vitamin metabolic processGO:0006766230.036
Fly
response to oxidative stressGO:00069791230.035
multicellular organismal signalingGO:0035637910.034
transmembrane transportGO:00550854120.033
cerebellum morphogenesisGO:0021587420.033
axon ensheathmentGO:0008366760.033
calcium ion dependent exocytosisGO:0017156350.033
peptidyl amino acid modificationGO:00181933360.033
cell type specific apoptotic processGO:00972852680.033
blood circulationGO:00080151950.033
cellular response to peptide hormone stimulusGO:0071375920.033
monosaccharide transportGO:0015749580.033
synapse organizationGO:00508081250.032
divalent inorganic cation transportGO:00725111780.032
sulfur compound metabolic processGO:00067901000.031
retinoid metabolic processGO:0001523240.031
cell adhesionGO:00071553290.031
negative regulation of kinase activityGO:0033673810.031
multi multicellular organism processGO:00447061090.031
cellular chemical homeostasisGO:00550822150.031
sperm egg recognitionGO:0035036370.030
platelet derived growth factor receptor alpha signaling pathwayGO:003579030.030
regulation of proteolysisGO:00301621640.030
fat cell differentiationGO:00454441600.030
hexose biosynthetic processGO:0019319390.030
regulation of mapk cascadeGO:00434082480.029
exocytosisGO:00068871210.029
myelinationGO:0042552740.029
monosaccharide metabolic processGO:00059961060.028
regulation of cellular carbohydrate metabolic processGO:0010675750.028
negative regulation of transferase activityGO:0051348850.028
circulatory system processGO:00030131970.028
response to light stimulusGO:00094161350.028
Fly
regulation of cell motilityGO:20001452360.027
regulation of hormone levelsGO:00108172110.027
regulation of secretion by cellGO:19035302490.027
positive regulation of cellular component biogenesisGO:0044089940.027
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.027
protein maturationGO:00516041760.026
cell recognitionGO:0008037830.026
activation of mapk activity involved in innate immune responseGO:003541920.026
immune effector processGO:00022523210.026
nucleoside phosphate metabolic processGO:00067533380.026
cell differentiation in hindbrainGO:0021533240.026
organic acid transportGO:00158491010.026
cerebellar cortex morphogenesisGO:0021696320.026
lipid localizationGO:00108761260.026
positive regulation of metanephric glomerulus developmentGO:007230040.025
cellular lipid catabolic processGO:0044242520.025
Mouse
metanephric glomerular epithelial cell differentiationGO:007231220.025
cellular divalent inorganic cation homeostasisGO:00725031270.025
ensheathment of neuronsGO:0007272760.025
detection of abiotic stimulusGO:0009582600.025
Fly
gluconeogenesisGO:0006094390.025
lipid oxidationGO:0034440290.025
lipid transportGO:0006869980.024
regulation of eosinophil migrationGO:200041620.024
cellular amino acid metabolic processGO:00065201030.024
organic hydroxy compound metabolic processGO:19016152030.024
brown fat cell differentiationGO:0050873360.024
negative regulation of multi organism processGO:0043901680.024
regulation of carbohydrate biosynthetic processGO:0043255400.024
cell cell adhesionGO:0098609410.024
negative regulation of cell developmentGO:00107211690.023
regulation of metanephric mesenchymal cell migrationGO:200058920.023
hindbrain developmentGO:00309021280.023
renal system processGO:0003014480.023
cellular response to radiationGO:0071478280.023
Fly
regulation of glucose transportGO:0010827320.023
glucose importGO:0046323320.023
multicellular organismal homeostasisGO:00488711640.023
neuron deathGO:00709971540.023
metanephric glomerular visceral epithelial cell developmentGO:007224920.022
positive regulation of proteolysisGO:0045862850.022
humoral immune response mediated by circulating immunoglobulinGO:0002455140.022
response to lipopolysaccharideGO:00324961280.022
response to acid chemicalGO:00011011110.022
regulation of ion homeostasisGO:2000021640.022
regulation of carbohydrate metabolic processGO:0006109750.022
regulation of secretionGO:00510462740.022
wound healingGO:00420601570.022
cellular calcium ion homeostasisGO:00068741190.022
detection of chemical stimulus involved in sensory perception of smellGO:005091140.022
negative regulation of platelet derived growth factor receptor alpha signaling pathwayGO:200058420.022
regulation of cellular amine metabolic processGO:0033238200.021
metanephric glomerular epithelium developmentGO:007224430.021
regulation of acetylcholine secretion neurotransmissionGO:001405620.021
hexose transportGO:0008645560.021
cellular response to abiotic stimulusGO:0071214560.021
regulation of cellular component biogenesisGO:00440871810.020
monosaccharide biosynthetic processGO:0046364440.020
nitrogen compound transportGO:00717052710.019
small molecule catabolic processGO:0044282710.019
apoptotic signaling pathwayGO:00971903060.019
cerebellar granular layer developmentGO:0021681130.019
protein homooligomerizationGO:0051260430.019
sensory perception of light stimulusGO:0050953540.019
defense response to other organismGO:00985421970.019
neuron neuron synaptic transmissionGO:0007270690.019
maintenance of locationGO:0051235890.019
retina homeostasisGO:0001895230.019
regulation of hydrolase activityGO:00513362460.019
detection of chemical stimulus involved in sensory perception of tasteGO:005091230.019
renal system developmentGO:00720012250.019
protein localization to organelleGO:00333651850.019
hormone metabolic processGO:0042445860.019
negative regulation of cellular amino acid metabolic processGO:004576300.019
regulation of fat cell differentiationGO:0045598810.019
regulation of glucose importGO:0046324260.018
positive regulation of eosinophil migrationGO:200041820.018
lipid modificationGO:0030258650.018
eosinophil migrationGO:007267730.018
lipid biosynthetic processGO:00086101790.018
Fly
cellular nitrogen compound catabolic processGO:00442702800.018
cell maturationGO:00484691270.018
positive regulation of thymocyte migrationGO:200041220.018
negative regulation of neuron deathGO:1901215980.018
cellular homeostasisGO:00197252400.018
negative regulation of protein modification processGO:00314001630.018
regulation of protein kinase b signalingGO:0051896560.017
ribonucleotide metabolic processGO:00092592910.017
associative learningGO:0008306610.017
ribose phosphate metabolic processGO:00196932910.017
negative regulation of cellular carbohydrate metabolic processGO:0010677190.017
positive regulation of glucose transportGO:0010828160.017
cell cell recognitionGO:0009988440.017
dendrite developmentGO:00163581150.017
positive regulation of nervous system developmentGO:00519622210.017
purine containing compound metabolic processGO:00725213110.017
platelet derived growth factor receptor signaling pathwayGO:0048008320.017
primary alcohol metabolic processGO:0034308110.016
peptidyl serine modificationGO:0018209830.016
skeletal muscle organ developmentGO:00605381630.016
nucleobase containing small molecule metabolic processGO:00550863520.016
cellular amine metabolic processGO:0044106440.016
protein oligomerizationGO:0051259670.016
glomerular visceral epithelial cell developmentGO:007201560.016
eye photoreceptor cell developmentGO:0042462310.016
positive regulation of cellular amine metabolic processGO:003324050.016
response to molecule of bacterial originGO:00022371430.016
glycosyl compound metabolic processGO:19016572460.016
learningGO:0007612980.016
sensory perception of mechanical stimulusGO:00509541070.016
ear developmentGO:00435832000.016
regulation of protein catabolic processGO:00421761080.016
detection of external stimulusGO:0009581610.016
Fly
negative regulation of fat cell differentiationGO:0045599360.016
positive regulation of protein kinase b signalingGO:0051897320.015
organic acid catabolic processGO:0016054510.015
locomotory behaviorGO:00076261950.015
thymocyte migrationGO:007267920.015
rhythmic processGO:00485111740.015
glomerulus developmentGO:0032835400.015
tissue homeostasisGO:00018941150.015
fatty acid oxidationGO:0019395280.015
sperm motilityGO:0030317470.015
prevention of polyspermyGO:006046840.015
cell differentiation involved in metanephros developmentGO:0072202120.015
regulation of neurotransmitter levelsGO:0001505870.015
endomembrane system organizationGO:00102561470.015
axonogenesisGO:00074092740.015
positive regulation of lipid metabolic processGO:0045834400.015
alcohol metabolic processGO:00060661160.015
posttranscriptional regulation of gene expressionGO:00106081550.015
germ cell developmentGO:00072811850.015
nucleoside phosphate catabolic processGO:19012922220.014
regulation of homeostatic processGO:00328441820.014
regulation of reactive oxygen species metabolic processGO:2000377400.014
Mouse
regulation of thymocyte migrationGO:200041020.014
synapse assemblyGO:0007416560.014
anion transportGO:00068201770.014
cognitionGO:00508901490.014
cerebellar granular layer morphogenesisGO:0021683100.014
epithelial cell developmentGO:00020641590.014
peptide metabolic processGO:0006518460.014
cellular amide metabolic processGO:0043603580.014
cellular response to lipidGO:00713961450.014
visual perceptionGO:0007601520.014
regulation of vesicle mediated transportGO:00606271390.014
cell migration involved in metanephros developmentGO:003578820.014
metanephric glomerular epithelial cell developmentGO:007231320.014
cellular macromolecule catabolic processGO:00442652060.014
regulation of cellular response to stressGO:00801351590.013
negative regulation of gluconeogenesisGO:004572190.013
regulation of establishment of protein localizationGO:00702011810.013
regulation of protein maturationGO:1903317960.013
cerebellar granular layer formationGO:002168490.013
single organismal cell cell adhesionGO:00163371310.013
response to inorganic substanceGO:0010035960.013
calcium ion homeostasisGO:00550741270.013
carboxylic acid transportGO:00469421000.013
organic cyclic compound catabolic processGO:19013612950.013
activation of mapk activityGO:0000187590.013
diterpenoid metabolic processGO:0016101240.013
male gamete generationGO:00482322850.013
positive regulation of cellular amino acid metabolic processGO:004576430.013
innate immune responseGO:00450871570.013
regulation of blood pressureGO:0008217930.013
chondroitin sulfate metabolic processGO:0030204170.013
cell divisionGO:00513011200.013
negative regulation of cell migrationGO:0030336590.013
glucose transportGO:0015758560.013
zymogen activationGO:0031638410.013
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.013
cellular response to cytokine stimulusGO:00713451890.013
positive regulation of secretion by cellGO:19035321140.013
negative regulation of carbohydrate metabolic processGO:0045912190.013
cerebellar cortex formationGO:0021697220.013
oocyte axis specificationGO:000730920.012
negative regulation of neuron apoptotic processGO:0043524920.012
nuclear transportGO:00511691390.012
sequestering of calcium ionGO:0051208180.012
sequestering of metal ionGO:0051238190.012
regulation of lipid transportGO:0032368360.012
cellular response to carbohydrate stimulusGO:0071322500.012
muscle contractionGO:00069361010.012
nucleoside metabolic processGO:00091162460.012
photoreceptor cell maintenanceGO:0045494190.012
myotube differentiationGO:00149021050.012
negative regulation of hydrolase activityGO:0051346710.012
regulation of gluconeogenesisGO:0006111300.012
cellular glucose homeostasisGO:0001678520.012
cellular extravasationGO:0045123170.012
negative regulation of endothelial cell migrationGO:001059640.012
divalent inorganic cation homeostasisGO:00725071380.012
leukocyte chemotaxisGO:0030595690.012
small gtpase mediated signal transductionGO:0007264970.012
regulation of endopeptidase activityGO:0052548890.012
positive regulation of membrane protein ectodomain proteolysisGO:005104430.012
olfactory learningGO:000835520.012
regulation of membrane protein ectodomain proteolysisGO:005104330.012
protein trimerizationGO:0070206130.012
regulation of platelet derived growth factor receptor signaling pathwayGO:001064090.012
divalent metal ion transportGO:00708381720.011
circadian rhythmGO:00076231140.011
amino acid transportGO:0006865610.011
regulation of protein localizationGO:00328802310.011
adult walking behaviorGO:0007628410.011
regulation of membrane potentialGO:00423911920.011
Mouse
positive regulation of lipid transportGO:0032370220.011
nucleocytoplasmic transportGO:00069131390.011
positive regulation of protein catabolic processGO:0045732600.011
regulation of fatty acid metabolic processGO:0019217280.011
activation of innate immune responseGO:0002218560.011
heart processGO:0003015940.011
heterophilic cell cell adhesion via plasma membrane cell adhesion moleculesGO:0007157200.011
acetate ester transportGO:190137420.011
cellular response to transforming growth factor beta stimulusGO:0071560880.011
protein heterooligomerizationGO:0051291140.011
compound eye developmentGO:004874910.011
neuron apoptotic processGO:00514021420.011
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:0007188540.011
regulation of circadian rhythmGO:0042752580.011
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.011
regulation of exocytosisGO:0017157610.011
negative regulation of cellular amine metabolic processGO:003323910.011
defense response to bacteriumGO:00427421190.011
organophosphate catabolic processGO:00464342320.011
regulation of blood circulationGO:1903522930.011
negative regulation of protein maturationGO:1903318790.011
negative regulation of protein processingGO:0010955790.011
carboxylic acid catabolic processGO:0046395510.011
protein importGO:00170381010.011
regulation of organelle organizationGO:00330432890.011
muscle system processGO:00030121410.011
kidney developmentGO:00018222130.011
heterocycle catabolic processGO:00467002800.011
regulation of peptidase activityGO:0052547960.011
striated muscle cell developmentGO:00550021250.011
eye photoreceptor cell differentiationGO:0001754410.010
detection of stimulus involved in sensory perceptionGO:0050906440.010
pma inducible membrane protein ectodomain proteolysisGO:005108810.010
myeloid leukocyte migrationGO:0097529570.010
visual behaviorGO:0007632450.010
muscle tissue developmentGO:00605373080.010
cellularizationGO:000734910.010
intracellular protein transportGO:00068862040.010
metanephric mesenchymal cell migrationGO:003578920.010
cellular response to organic cyclic compoundGO:0071407870.010
small molecule biosynthetic processGO:00442831320.010
Fly

Rpe65 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
eye diseaseDOID:561400.577
nervous system diseaseDOID:86300.577
eye and adnexa diseaseDOID:149200.577
disease of anatomical entityDOID:700.577
sensory system diseaseDOID:005015500.577
night blindnessDOID:849900.577
retinal diseaseDOID:567900.577
retinitis pigmentosaDOID:1058400.378
retinal degenerationDOID:846600.378
central nervous system diseaseDOID:33100.011