Mus musculus

54 known processes

Spire1

spire homolog 1 (Drosophila)

(Aliases: AW550622,Spir-1,AI415299,AU022898,6030430B19Rik)

Spire1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
transmembrane transportGO:00550854120.066
amine metabolic processGO:0009308450.062
cation transportGO:00068123990.059
ion transmembrane transportGO:00342203610.051
cellular amine metabolic processGO:0044106440.051
cellular lipid metabolic processGO:00442553230.049
regulation of cellular ketone metabolic processGO:0010565660.047
cellular amino acid metabolic processGO:00065201030.047
nucleobase containing small molecule metabolic processGO:00550863520.046
purine containing compound metabolic processGO:00725213110.044
organic cyclic compound catabolic processGO:19013612950.044
regulation of cellular catabolic processGO:00313292420.043
purine nucleotide metabolic processGO:00061633020.043
purine ribonucleoside metabolic processGO:00461282410.043
small gtpase mediated signal transductionGO:0007264970.043
anion transportGO:00068201770.043
regulation of cellular amino acid metabolic processGO:000652150.043
regulation of cellular amine metabolic processGO:0033238200.041
regulation of membrane potentialGO:00423911920.040
regulation of organelle organizationGO:00330432890.039
purine nucleoside metabolic processGO:00422782410.039
aromatic compound catabolic processGO:00194392860.039
membrane organizationGO:00610242450.039
nucleoside phosphate metabolic processGO:00067533380.039
ras protein signal transductionGO:0007265770.039
nucleoside triphosphate metabolic processGO:00091412300.038
nucleotide metabolic processGO:00091173320.038
ribonucleoside metabolic processGO:00091192450.038
ribonucleotide metabolic processGO:00092592910.038
cellular ketone metabolic processGO:0042180840.038
positive regulation of cellular amino acid metabolic processGO:004576430.038
cation transmembrane transportGO:00986552660.037
purine ribonucleotide metabolic processGO:00091502900.037
organophosphate catabolic processGO:00464342320.036
organonitrogen compound catabolic processGO:19015652640.035
ribose phosphate metabolic processGO:00196932910.035
cellular nitrogen compound catabolic processGO:00442702800.035
regulation of hydrolase activityGO:00513362460.035
ribonucleoside triphosphate catabolic processGO:00092031990.034
multicellular organismal signalingGO:0035637910.034
heterocycle catabolic processGO:00467002800.033
glycosyl compound metabolic processGO:19016572460.033
nucleoside catabolic processGO:00091642060.032
ribonucleoside triphosphate metabolic processGO:00091992200.032
inorganic ion transmembrane transportGO:00986602340.032
nitrogen compound transportGO:00717052710.032
neuronal action potentialGO:0019228540.032
purine containing compound catabolic processGO:00725232130.031
glycosyl compound catabolic processGO:19016582060.031
lipid biosynthetic processGO:00086101790.031
nucleoside metabolic processGO:00091162460.031
positive regulation of purine nucleotide metabolic processGO:19005441140.030
negative regulation of cellular amine metabolic processGO:003323910.030
response to organonitrogen compoundGO:00102432460.030
ribonucleoside catabolic processGO:00424542060.030
protein modification by small protein conjugation or removalGO:00706472070.029
negative regulation of protein metabolic processGO:00512482820.029
purine ribonucleoside catabolic processGO:00461302050.029
purine nucleotide catabolic processGO:00061952110.029
purine nucleoside triphosphate metabolic processGO:00091442260.029
positive regulation of cellular catabolic processGO:00313311480.028
carbohydrate derivative catabolic processGO:19011362310.028
action potentialGO:0001508780.028
purine nucleoside catabolic processGO:00061522050.028
organelle localizationGO:00516401790.028
regulation of gtp catabolic processGO:00331241130.028
positive regulation of cellular amine metabolic processGO:003324050.028
inorganic cation transmembrane transportGO:00986622070.028
gtp metabolic processGO:00460391440.028
guanosine containing compound metabolic processGO:19010681440.028
transmission of nerve impulseGO:0019226760.028
regulation of nucleotide metabolic processGO:00061401690.027
regulation of protein kinase activityGO:00458592320.027
negative regulation of cellular protein metabolic processGO:00322692470.027
nucleoside phosphate catabolic processGO:19012922220.027
carboxylic acid biosynthetic processGO:0046394860.027
oxidation reduction processGO:00551143420.027
organonitrogen compound biosynthetic processGO:19015661920.027
apoptotic signaling pathwayGO:00971903060.027
regulation of anatomical structure sizeGO:00900661780.026
purine ribonucleoside triphosphate metabolic processGO:00092052200.026
actin cytoskeleton organizationGO:00300362200.026
axonogenesisGO:00074092740.026
negative regulation of cellular component organizationGO:00511291940.026
regulation of transmembrane transportGO:00347621280.026
protein catabolic processGO:00301632210.026
ribonucleotide catabolic processGO:00092612080.026
endomembrane system organizationGO:00102561470.026
negative regulation of cellular amino acid metabolic processGO:004576300.026
peptidyl amino acid modificationGO:00181933360.025
divalent metal ion transportGO:00708381720.025
positive regulation of gtp catabolic processGO:0033126850.025
regulation of neuron differentiationGO:00456642810.025
regulation of ion transportGO:00432692150.025
purine ribonucleotide catabolic processGO:00091542080.024
purine nucleoside triphosphate catabolic processGO:00091462030.024
striated muscle tissue developmentGO:00147062930.024
microtubule based processGO:00070172360.024
regulation of ion transmembrane transportGO:00347651190.024
purine ribonucleoside triphosphate catabolic processGO:00092071990.024
regulation of transferase activityGO:00513382630.024
macromolecule catabolic processGO:00090572810.024
small molecule biosynthetic processGO:00442831320.024
regulation of vesicle mediated transportGO:00606271390.024
protein ubiquitinationGO:00165671710.024
nucleoside triphosphate catabolic processGO:00091432050.024
organic hydroxy compound metabolic processGO:19016152030.024
guanosine containing compound catabolic processGO:19010691440.024
protein localization to membraneGO:00726571080.024
cellular macromolecule catabolic processGO:00442652060.024
cellular homeostasisGO:00197252400.024
negative regulation of phosphate metabolic processGO:00459361840.024
cellular response to organonitrogen compoundGO:00714171450.024
regulation of purine nucleotide metabolic processGO:19005421690.023
regulation of kinase activityGO:00435492490.023
monocarboxylic acid metabolic processGO:00327871910.023
positive regulation of hydrolase activityGO:00513451480.023
positive regulation of purine nucleotide catabolic processGO:0033123880.023
mapk cascadeGO:00001652810.022
regulation of cellular component biogenesisGO:00440871810.022
regulation of purine nucleotide catabolic processGO:00331211220.022
locomotory behaviorGO:00076261950.022
regulation of nucleoside metabolic processGO:00091181300.022
gtp catabolic processGO:00061841430.022
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.022
rho protein signal transductionGO:0007266320.022
synaptic transmissionGO:00072683290.022
positive regulation of nucleotide metabolic processGO:00459811140.022
negative regulation of molecular functionGO:00440922580.022
carbohydrate metabolic processGO:00059752300.022
organic anion transportGO:00157111370.022
nucleotide catabolic processGO:00091662170.022
divalent inorganic cation transportGO:00725111780.022
regulation of cytoskeleton organizationGO:00514931220.022
maintenance of locationGO:0051235890.021
protein modification by small protein conjugationGO:00324461870.021
regulation of cell projection organizationGO:00313442060.021
positive regulation of nucleoside metabolic processGO:0045979910.021
negative regulation of phosphorus metabolic processGO:00105631840.021
neuron deathGO:00709971540.021
regulation of nucleotide catabolic processGO:00308111220.021
male gamete generationGO:00482322850.020
positive regulation of gtpase activityGO:0043547850.020
muscle cell differentiationGO:00426922610.020
regulation of cell cycleGO:00517262810.020
muscle tissue developmentGO:00605373080.020
cytoplasmic transportGO:00164822340.020
chemotaxisGO:00069352470.020
sensory perceptionGO:00076002450.019
positive regulation of protein modification processGO:00314012990.019
cell type specific apoptotic processGO:00972852680.019
camera type eye developmentGO:00430102660.019
sensory organ morphogenesisGO:00905962420.019
microtubule cytoskeleton organizationGO:00002261570.019
protein maturationGO:00516041760.019
cellular chemical homeostasisGO:00550822150.019
reactive oxygen species metabolic processGO:0072593840.019
negative regulation of phosphorylationGO:00423261660.019
immune effector processGO:00022523210.019
positive regulation of nucleotide catabolic processGO:0030813880.019
negative regulation of protein modification processGO:00314001630.018
posttranscriptional regulation of gene expressionGO:00106081550.018
organic acid transportGO:00158491010.018
amino acid transmembrane transportGO:0003333370.018
regulation of cellular component sizeGO:00325351210.018
g protein coupled receptor signaling pathwayGO:00071862430.018
regulation of synaptic growth at neuromuscular junctionGO:000858240.018
axon ensheathmentGO:0008366760.018
intracellular protein transportGO:00068862040.018
spermatogenesisGO:00072832840.018
cellular response to hormone stimulusGO:00328701500.018
carboxylic acid transportGO:00469421000.018
response to peptideGO:19016521360.018
regulation of protein localizationGO:00328802310.017
compound eye developmentGO:004874910.017
regulation of homeostatic processGO:00328441820.017
endocytosisGO:00068971680.017
organic acid biosynthetic processGO:0016053860.017
carbohydrate derivative biosynthetic processGO:19011371830.017
negative regulation of intracellular signal transductionGO:19025321670.017
learning or memoryGO:00076111480.017
cell adhesionGO:00071553290.017
calcium ion transportGO:00068161590.017
gland developmentGO:00487323300.017
plasma membrane organizationGO:0007009900.017
fat cell differentiationGO:00454441600.017
myeloid cell differentiationGO:00300992330.017
response to organic cyclic compoundGO:00140701980.017
forebrain developmentGO:00309003020.017
establishment of organelle localizationGO:00516561220.017
calcium ion transmembrane transportGO:0070588850.016
glycerolipid metabolic processGO:00464861220.016
regulation of apoptotic signaling pathwayGO:20012331970.016
positive regulation of cell developmentGO:00107202370.016
organelle assemblyGO:00709251770.016
regulation of mapk cascadeGO:00434082480.016
engulfment of apoptotic cellGO:004365230.016
cation homeostasisGO:00550802120.016
fatty acid metabolic processGO:00066311210.016
modification dependent protein catabolic processGO:00199411330.016
cellular protein catabolic processGO:00442571550.016
regulation of actin filament based processGO:0032970990.016
protein localization to plasma membraneGO:0072659570.016
protein localization to organelleGO:00333651850.016
positive regulation of protein phosphorylationGO:00019342420.016
cellular ion homeostasisGO:00068731650.016
positive regulation of kinase activityGO:00336741550.016
regulation of cell morphogenesis involved in differentiationGO:00107691510.015
protein processingGO:00164851630.015
regulation of protein serine threonine kinase activityGO:00719001570.015
epithelial tube morphogenesisGO:00605623030.015
developmental maturationGO:00217001930.015
skeletal muscle organ developmentGO:00605381630.015
negative regulation of protein phosphorylationGO:00019331260.015
cellular protein complex assemblyGO:00436231160.015
cellular component assembly involved in morphogenesisGO:00109271390.015
negative regulation of cell proliferationGO:00082852960.015
leukocyte differentiationGO:00025213420.015
neuromuscular processGO:0050905990.015
rhythmic processGO:00485111740.015
regulation of cell motilityGO:20001452360.015
regulation of secretion by cellGO:19035302490.015
neuron apoptotic processGO:00514021420.015
regulation of neuron deathGO:19012141340.015
regulation of ion transmembrane transporter activityGO:0032412540.015
lipid localizationGO:00108761260.015
homeostasis of number of cellsGO:00488722100.015
exocytosisGO:00068871210.015
skeletal system developmentGO:00015013560.015
synapse organizationGO:00508081250.015
negative regulation of cell developmentGO:00107211690.015
positive regulation of ras gtpase activityGO:0032320650.015
dna metabolic processGO:00062593030.015
regulation of hormone levelsGO:00108172110.015
negative regulation of neuron apoptotic processGO:0043524920.015
morphogenesis of embryonic epitheliumGO:00163311590.014
germ cell developmentGO:00072811850.014
regulation of cell migrationGO:00303342190.014
circulatory system processGO:00030131970.014
retrograde transport endosome to golgiGO:004214720.014
proteolysis involved in cellular protein catabolic processGO:00516031470.014
actin filament organizationGO:00070151130.014
regulation of metal ion transportGO:00109591060.014
cognitionGO:00508901490.014
angiogenesisGO:00015252010.014
hematopoietic progenitor cell differentiationGO:00022441430.014
adult behaviorGO:00305341350.014
response to peptide hormoneGO:00434341270.014
establishment of vesicle localizationGO:0051650810.014
protein targetingGO:00066051430.014
lateral inhibitionGO:004633110.014
cytokine productionGO:00018163190.014
nuclear divisionGO:00002801580.014
positive regulation of nervous system developmentGO:00519622210.014
positive regulation of transferase activityGO:00513471670.014
vesicle localizationGO:0051648860.014
negative regulation of neuron deathGO:1901215980.014
phospholipid metabolic processGO:0006644870.014
regulation of neuron apoptotic processGO:00435231220.014
developmental growth involved in morphogenesisGO:00605601380.014
cellular metal ion homeostasisGO:00068751510.014
cellular response to dna damage stimulusGO:00069742070.014
dephosphorylationGO:00163111290.014
ubiquitin dependent protein catabolic processGO:00065111290.013
anion transmembrane transportGO:0098656710.013
regulation of secretionGO:00510462740.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.013
multicellular organismal homeostasisGO:00488711640.013
regulation of cellular response to stressGO:00801351590.013
regulation of proteolysisGO:00301621640.013
amide transportGO:00428861380.013
organelle fissionGO:00482851700.013
response to insulinGO:00328681000.013
negative regulation of nervous system developmentGO:00519611560.013
positive regulation of organelle organizationGO:00106381280.013
myosin filament assemblyGO:003103420.013
response to growth factorGO:00708481980.013
regulation of ras protein signal transductionGO:00465781140.013
monocarboxylic acid biosynthetic processGO:0072330610.013
lipid transportGO:0006869980.013
carbohydrate homeostasisGO:00335001280.013
morphogenesis of a branching structureGO:00017632030.013
response to acid chemicalGO:00011011110.013
regulation of reactive oxygen species metabolic processGO:2000377400.013
microtubule nucleationGO:000702020.013
cofactor metabolic processGO:0051186800.013
hexose metabolic processGO:0019318980.013
neural tube developmentGO:00219151600.013
alcohol metabolic processGO:00060661160.013
ensheathment of neuronsGO:0007272760.013
blood vessel morphogenesisGO:00485142850.013
mitotic cell cycleGO:00002781950.013
regulation of transporter activityGO:0032409570.013
skin developmentGO:00435882200.013
regulation of protein catabolic processGO:00421761080.013
striated muscle myosin thick filament assemblyGO:007168810.013
fertilizationGO:00095661270.013
multicellular organism growthGO:00352641610.012
protein polymerizationGO:0051258570.012
regulation of actin cytoskeleton organizationGO:0032956840.012
amino acid transportGO:0006865610.012
metal ion homeostasisGO:00550651890.012
epithelial cell developmentGO:00020641590.012
glucose homeostasisGO:00425931280.012
actin filament based movementGO:0030048230.012
chromatin organizationGO:00063252060.012
regulation of neuron projection developmentGO:00109751690.012
wnt signaling pathwayGO:00160551880.012
tube formationGO:00351481400.012
cell growthGO:00160491300.012
cellular response to peptide hormone stimulusGO:0071375920.012
modification dependent macromolecule catabolic processGO:00436321330.012
response to inorganic substanceGO:0010035960.012
muscle system processGO:00030121410.012
regulation of cell sizeGO:0008361720.012
ossificationGO:00015032160.012
ear developmentGO:00435832000.012
cell divisionGO:00513011200.012
spermatid differentiationGO:00485151150.012
blood circulationGO:00080151950.012
lymphocyte differentiationGO:00300982420.012
regulation of establishment of protein localizationGO:00702011810.012
regulation of lymphocyte activationGO:00512492400.012
glycoprotein metabolic processGO:00091001160.012
t cell activationGO:00421102890.012
cellular response to growth factor stimulusGO:00713631970.012
regulation of ras gtpase activityGO:0032318880.012
embryonic epithelial tube formationGO:00018381300.012
neural tube formationGO:00018411080.012
positive regulation of protein kinase activityGO:00458601440.012
organophosphate biosynthetic processGO:00904071220.012
regulation of endocytosisGO:0030100690.012
positive regulation of protein serine threonine kinase activityGO:00719021060.012
sequestering of calcium ionGO:0051208180.012
spermatid developmentGO:00072861080.012
establishment or maintenance of cytoskeleton polarityGO:003095220.012
retina development in camera type eyeGO:00600411190.012
regulation of intracellular transportGO:00323861590.012
regulation of calcium ion transportGO:0051924690.012
neuron projection guidanceGO:00974851410.012
response to radiationGO:00093141650.012
mitochondrion organizationGO:00070051340.012
regulation of cell activationGO:00508652890.011
positive regulation of cell deathGO:00109422240.011
regionalizationGO:00030023370.011
negative regulation of growthGO:0045926990.011
organic hydroxy compound biosynthetic processGO:1901617770.011
respiratory system developmentGO:00605411900.011
myotube differentiationGO:00149021050.011
reactive nitrogen species metabolic processGO:200105700.011
positive regulation of neuron differentiationGO:00456661410.011
dendrite developmentGO:00163581150.011
actin polymerization or depolymerizationGO:0008154540.011
cellular carbohydrate metabolic processGO:00442621190.011
glycerophospholipid metabolic processGO:0006650710.011
cellular response to cytokine stimulusGO:00713451890.011
inflammatory responseGO:00069542440.011
regulation of reactive oxygen species biosynthetic processGO:190342620.011
development of primary sexual characteristicsGO:00451371430.011
regulation of lipid metabolic processGO:00192161180.011
regulation of cell adhesionGO:00301551540.011
single organism cell adhesionGO:00986021560.011
embryonic organ morphogenesisGO:00485622760.011
negative regulation of organelle organizationGO:0010639900.011
peptide transportGO:00158331330.011
regulation of cell cycle processGO:00105641600.011
regulation of system processGO:00440572000.011
tissue homeostasisGO:00018941150.011
sulfur compound metabolic processGO:00067901000.011
positive regulation of smooth muscle cell migrationGO:001491140.011
mitotic cell cycle processGO:19030471590.011
fatty acid biosynthetic processGO:0006633410.011
myosin filament organizationGO:003103330.011
vesicle organizationGO:0016050600.011
learningGO:0007612980.011
muscle contractionGO:00069361010.011
negative regulation of apoptotic signaling pathwayGO:20012341040.011
intracellular mrna localizationGO:000829840.011
neuron migrationGO:00017641220.011
methylationGO:00322591340.011
telencephalon developmentGO:00215371860.011
regulation of feeding behaviorGO:006025930.011
response to extracellular stimulusGO:00099911270.011
epithelial tube formationGO:00721751300.011
regulation of map kinase activityGO:00434051200.011
hormone secretionGO:00468791280.011
cellular response to peptideGO:1901653920.011
anatomical structure homeostasisGO:00602491450.011
divalent inorganic cation homeostasisGO:00725071380.010
midgut developmentGO:000749440.010
reactive oxygen species biosynthetic processGO:190340980.010
circadian rhythmGO:00076231140.010
extrinsic apoptotic signaling pathwayGO:00971911260.010
calcium ion homeostasisGO:00550741270.010
response to nutrient levelsGO:00316671090.010
negative regulation of transferase activityGO:0051348850.010
leukocyte migrationGO:00509001240.010
positive regulation of cellular component biogenesisGO:0044089940.010
establishment or maintenance of microtubule cytoskeleton polarityGO:003095110.010
epidermis developmentGO:00085441870.010
cell maturationGO:00484691270.010
carbohydrate transportGO:0008643620.010
wound healingGO:00420601570.010
cellular response to insulin stimulusGO:0032869780.010
establishment of protein localization to organelleGO:00725941180.010
striated muscle cell developmentGO:00550021250.010
response to oxygen levelsGO:0070482620.010
epithelial cell proliferationGO:00506731740.010
monosaccharide metabolic processGO:00059961060.010
response to light stimulusGO:00094161350.010
positive regulation of apoptotic processGO:00430652170.010
proteasomal protein catabolic processGO:0010498980.010
membrane lipid metabolic processGO:0006643530.010

Spire1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.032
disease of anatomical entityDOID:700.032
central nervous system diseaseDOID:33100.019
immune system diseaseDOID:291400.017
hematopoietic system diseaseDOID:7400.015
cancerDOID:16200.014
organ system cancerDOID:005068600.014
disease of cellular proliferationDOID:1456600.014
disease of metabolismDOID:001466700.012
inherited metabolic disorderDOID:65500.012
musculoskeletal system diseaseDOID:1700.012
connective tissue diseaseDOID:6500.011
neurodegenerative diseaseDOID:128900.010