IMP: Integrative Multi-species Prediction

Mus musculus

128 known processes

Flt3

FMS-like tyrosine kinase 3

(Aliases: Flt-3,Flk2,B230315G04,Flk-2,MGC124378,wmfl,CD135,Ly72,MGC124377)

Entrez: 14255
Ensembl: ENSMUSG00000042817
UniProtKB: Q3UEW6
UniProtKB: Q3TQF1
UniProtKB: Q00342

Process Predictions
Disease Predictions

Flt3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
t cell activation	GO:0042110	289	0.714
leukocyte differentiation	GO:0002521	342	0.712
immune response activating signal transduction	GO:0002757	116	0.621
cytokine production	GO:0001816	319	0.609	Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.594
activation of immune response	GO:0002253	138	0.583
cell recognition	GO:0008037	83	0.552
myeloid cell differentiation	GO:0030099	233	0.540	Mouse
positive regulation of cytokine production	GO:0001819	174	0.501
response to lipopolysaccharide	GO:0032496	128	0.498
hematopoietic stem cell migration	GO:0035701	1	0.479
regulation of cytokine production	GO:0001817	266	0.476
lymphocyte proliferation	GO:0046651	164	0.449
lymphocyte differentiation	GO:0030098	242	0.443
regulation of t cell activation	GO:0050863	170	0.438
transmembrane transport	GO:0055085	412	0.425	Mouse
cytokine biosynthetic process	GO:0042089	68	0.402
membrane organization	GO:0061024	245	0.397
regulation of ion homeostasis	GO:2000021	64	0.397
regulation of monocyte chemotaxis	GO:0090025	3	0.389
adaptive immune response	GO:0002250	155	0.384
positive regulation of tumor necrosis factor superfamily cytokine production	GO:1903557	31	0.367
regulation of adaptive immune response	GO:0002819	90	0.366
positive regulation of monocyte chemotaxis	GO:0090026	2	0.353
regulation of cytokine biosynthetic process	GO:0042035	59	0.350
positive regulation of t cell activation	GO:0050870	101	0.343
positive regulation of tumor necrosis factor production	GO:0032760	30	0.340
cell cell recognition	GO:0009988	44	0.326
mature dendritic cell differentiation	GO:0097029	3	0.322
cell chemotaxis	GO:0060326	81	0.322	Mouse
regulation of establishment of protein localization	GO:0070201	181	0.321
defense response to other organism	GO:0098542	197	0.320
sequestering of calcium ion	GO:0051208	18	0.316
action potential	GO:0001508	78	0.304
cellular response to lipid	GO:0071396	145	0.303	Rat
t cell differentiation	GO:0030217	174	0.299
cytokine mediated signaling pathway	GO:0019221	115	0.297
regulation of leukocyte apoptotic process	GO:2000106	56	0.272
leukocyte activation involved in immune response	GO:0002366	126	0.265
alpha beta t cell activation	GO:0046631	91	0.243
divalent inorganic cation transport	GO:0072511	178	0.240	Mouse
single organismal cell cell adhesion	GO:0016337	131	0.236	Mouse
activation of innate immune response	GO:0002218	56	0.236
regulation of lymphocyte activation	GO:0051249	240	0.235
negative regulation of immune system process	GO:0002683	209	0.233
regulation of response to wounding	GO:1903034	189	0.232
immune response regulating signaling pathway	GO:0002764	125	0.230
regulation of membrane potential	GO:0042391	192	0.218
natural killer cell activation	GO:0030101	44	0.213
cytosolic calcium ion transport	GO:0060401	48	0.211
lymphocyte mediated immunity	GO:0002449	139	0.210
germ cell development	GO:0007281	185	0.207	Mouse Fly
immune effector process	GO:0002252	321	0.206	Mouse
regulation of intracellular transport	GO:0032386	159	0.200
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.198
regulation of tumor necrosis factor production	GO:0032680	49	0.198
defense response to bacterium	GO:0042742	119	0.197
multicellular organismal signaling	GO:0035637	91	0.197
tumor necrosis factor production	GO:0032640	50	0.197
regulation of lymphocyte proliferation	GO:0050670	117	0.197
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.195
myeloid leukocyte differentiation	GO:0002573	119	0.194	Mouse
leukocyte chemotaxis	GO:0030595	69	0.191
t cell proliferation	GO:0042098	120	0.190
mapk cascade	GO:0000165	281	0.187	Mouse Fly
inflammatory response	GO:0006954	244	0.183	Mouse
negative regulation of homeostatic process	GO:0032845	71	0.180
regulation of vesicle mediated transport	GO:0060627	139	0.179
positive regulation of protein secretion	GO:0050714	52	0.177
blood vessel morphogenesis	GO:0048514	285	0.175	Mouse
regulation of protein localization	GO:0032880	231	0.175
protein secretion	GO:0009306	111	0.164
cell activation involved in immune response	GO:0002263	126	0.163
cytokine secretion	GO:0050663	72	0.163
cell killing	GO:0001906	67	0.162
regulation of type 2 immune response	GO:0002828	18	0.161
glycoprotein biosynthetic process	GO:0009101	89	0.160
cytokine metabolic process	GO:0042107	71	0.160
muscle cell development	GO:0055001	133	0.157	Mouse
humoral immune response	GO:0006959	57	0.156	Fly
neuronal action potential	GO:0019228	54	0.155
cellular amino acid metabolic process	GO:0006520	103	0.152
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.151
metal ion homeostasis	GO:0055065	189	0.151	Mouse
cellular response to molecule of bacterial origin	GO:0071219	83	0.149
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.149
actin cytoskeleton organization	GO:0030036	220	0.149	Mouse Fly
regulation of defense response	GO:0031347	233	0.147
phagocytosis	GO:0006909	66	0.146
sequestering of metal ion	GO:0051238	19	0.146
transmission of nerve impulse	GO:0019226	76	0.145
epithelial tube morphogenesis	GO:0060562	303	0.145	Mouse Fly
positive regulation of neuron differentiation	GO:0045666	141	0.144
carbohydrate derivative biosynthetic process	GO:1901137	183	0.143
positive regulation of defense response	GO:0031349	124	0.142
regulation of leukocyte mediated immunity	GO:0002703	104	0.140
positive regulation of cell development	GO:0010720	237	0.139
cation transport	GO:0006812	399	0.139	Mouse
reactive oxygen species metabolic process	GO:0072593	84	0.139	Mouse
cell type specific apoptotic process	GO:0097285	268	0.139
leukocyte apoptotic process	GO:0071887	71	0.136
regulation of endocytosis	GO:0030100	69	0.134
stimulatory c type lectin receptor signaling pathway	GO:0002223	2	0.134
g protein coupled receptor signaling pathway	GO:0007186	243	0.134
regulation of interferon gamma production	GO:0032649	57	0.133
myeloid leukocyte migration	GO:0097529	57	0.133
cellular response to lipopolysaccharide	GO:0071222	77	0.132
monocyte extravasation	GO:0035696	2	0.132
cellular calcium ion homeostasis	GO:0006874	119	0.132
regulation of protein transport	GO:0051223	163	0.132
axon ensheathment	GO:0008366	76	0.131
negative regulation of multi organism process	GO:0043901	68	0.131
angiogenesis	GO:0001525	201	0.128	Mouse
negative regulation of cell activation	GO:0050866	111	0.128
chemokine mediated signaling pathway	GO:0070098	17	0.126
axonogenesis	GO:0007409	274	0.126
regulation of hematopoietic stem cell migration	GO:2000471	1	0.124
positive regulation of phagocytosis	GO:0050766	26	0.124
gliogenesis	GO:0042063	141	0.121
regulation of cytokine secretion	GO:0050707	61	0.120
regulation of secretion by cell	GO:1903530	249	0.120
cellular response to cytokine stimulus	GO:0071345	189	0.119
cytoplasmic transport	GO:0016482	234	0.119
positive regulation of protein modification process	GO:0031401	299	0.119
positive regulation of interferon gamma production	GO:0032729	39	0.118
positive regulation of gliogenesis	GO:0014015	27	0.118
innate immune response	GO:0045087	157	0.118	Fly
ion transmembrane transport	GO:0034220	361	0.118	Mouse
regulation of anatomical structure size	GO:0090066	178	0.118
regulation of homeostatic process	GO:0032844	182	0.118
anatomical structure homeostasis	GO:0060249	145	0.118	Mouse
interleukin 12 secretion	GO:0072610	3	0.117
divalent metal ion transport	GO:0070838	172	0.116	Mouse
synaptic transmission	GO:0007268	329	0.114
leukocyte migration	GO:0050900	124	0.114
cellular response to biotic stimulus	GO:0071216	92	0.111
regulation of cellular amine metabolic process	GO:0033238	20	0.111
regulation of kinase activity	GO:0043549	249	0.111	Mouse
helper t cell chemotaxis	GO:0035704	1	0.110
positive regulation of cell projection organization	GO:0031346	95	0.109
endocytosis	GO:0006897	168	0.109
small gtpase mediated signal transduction	GO:0007264	97	0.109
b cell activation	GO:0042113	161	0.108
chemotaxis	GO:0006935	247	0.108	Mouse
positive regulation of immune effector process	GO:0002699	107	0.107
myeloid leukocyte mediated immunity	GO:0002444	42	0.106
granulocyte migration	GO:0097530	43	0.102
positive regulation of nervous system development	GO:0051962	221	0.101
regulation of cell projection organization	GO:0031344	206	0.101
leukocyte proliferation	GO:0070661	172	0.101
leukocyte mediated immunity	GO:0002443	174	0.100	Mouse
amine metabolic process	GO:0009308	45	0.099
reactive nitrogen species metabolic process	GO:2001057	0	0.099
regulation of cellular response to stress	GO:0080135	159	0.099
regulation of ion transport	GO:0043269	215	0.098	Mouse
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.098
neuron projection guidance	GO:0097485	141	0.097
regulation of neuron projection development	GO:0010975	169	0.096
leukocyte mediated cytotoxicity	GO:0001909	62	0.096
myeloid leukocyte activation	GO:0002274	83	0.096
single organism cell adhesion	GO:0098602	156	0.096	Mouse
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.094
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.094
defense response to virus	GO:0051607	68	0.092
granulocyte chemotaxis	GO:0071621	39	0.092
positive regulation of cytosolic calcium ion concentration	GO:0007204	65	0.090
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.090
negative regulation of defense response	GO:0031348	77	0.090
detection of other organism	GO:0098543	8	0.090
regulation of protein secretion	GO:0050708	82	0.090
positive regulation of angiogenesis	GO:0045766	46	0.089	Mouse
homeostasis of number of cells	GO:0048872	210	0.088
activation of mapk activity involved in innate immune response	GO:0035419	2	0.088
innate immune response activating signal transduction	GO:0002758	50	0.088
regulation of innate immune response	GO:0045088	91	0.088
negative regulation of phagocytosis	GO:0050765	4	0.087
eosinophil activation	GO:0043307	1	0.087
eosinophil degranulation	GO:0043308	1	0.087
regulation of epithelial cell proliferation	GO:0050678	141	0.087	Mouse
glial cell development	GO:0021782	54	0.087
eosinophil mediated immunity	GO:0002447	1	0.086
negative regulation of immune effector process	GO:0002698	55	0.085
regulation of t cell proliferation	GO:0042129	92	0.085
multicellular organismal homeostasis	GO:0048871	164	0.084	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.084	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.084
eosinophil migration	GO:0072677	3	0.084
cation homeostasis	GO:0055080	212	0.084	Mouse
response to molecule of bacterial origin	GO:0002237	143	0.083
membrane invagination	GO:0010324	17	0.083
cognition	GO:0050890	149	0.083
calcium ion transport into cytosol	GO:0060402	48	0.081
regulation of transferase activity	GO:0051338	263	0.080	Mouse
ensheathment of neurons	GO:0007272	76	0.078
regulation of phagocytosis	GO:0050764	33	0.078
positive regulation of lymphocyte activation	GO:0051251	140	0.078
myelination	GO:0042552	74	0.077
cytosolic calcium ion homeostasis	GO:0051480	70	0.077
regulation of interleukin 12 production	GO:0032655	30	0.077
negative regulation of macrophage apoptotic process	GO:2000110	3	0.077
regulation of cellular component size	GO:0032535	121	0.076
positive regulation of neuron projection development	GO:0010976	79	0.076
regulation of apoptotic signaling pathway	GO:2001233	197	0.076
learning or memory	GO:0007611	148	0.075
calcium ion transport	GO:0006816	159	0.075	Mouse
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.075
interferon gamma production	GO:0032609	67	0.074
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.072
positive regulation of cell activation	GO:0050867	158	0.072
regulation of cell activation	GO:0050865	289	0.071
positive regulation of innate immune response	GO:0045089	80	0.071
forebrain development	GO:0030900	302	0.071
cellular lipid metabolic process	GO:0044255	323	0.071	Mouse
maintenance of location	GO:0051235	89	0.071
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.069	Mouse
single fertilization	GO:0007338	82	0.069
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.069
regulation of leukocyte proliferation	GO:0070663	121	0.069
regulation of neuron differentiation	GO:0045664	281	0.069
exocytosis	GO:0006887	121	0.068
muscle tissue development	GO:0060537	308	0.068	Mouse
endomembrane system organization	GO:0010256	147	0.068
pattern recognition receptor signaling pathway	GO:0002221	47	0.068
interleukin 12 production	GO:0032615	32	0.067
glial cell differentiation	GO:0010001	131	0.067
circulatory system process	GO:0003013	197	0.067
detection of yeast	GO:0001879	2	0.067
regulation of cellular component biogenesis	GO:0044087	181	0.067
t helper 17 cell chemotaxis	GO:0035705	1	0.067
positive regulation of endocytosis	GO:0045807	42	0.066
peptidyl tyrosine phosphorylation	GO:0018108	143	0.066
regulation of t cell differentiation	GO:0045580	83	0.066
response to organic cyclic compound	GO:0014070	198	0.066	Rat
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.066
activation of membrane attack complex	GO:0001905	4	0.065
cd4 positive alpha beta t cell activation	GO:0035710	45	0.065
positive regulation of leukocyte proliferation	GO:0070665	73	0.065
bone remodeling	GO:0046849	53	0.064
positive regulation of adaptive immune response	GO:0002821	61	0.063
positive regulation of dendritic cell chemotaxis	GO:2000510	1	0.063
glycoprotein metabolic process	GO:0009100	116	0.063
positive regulation of leukocyte differentiation	GO:1902107	86	0.063
epidermis development	GO:0008544	187	0.062
response to growth factor	GO:0070848	198	0.062	Mouse
alpha beta t cell differentiation	GO:0046632	69	0.062
response to organonitrogen compound	GO:0010243	246	0.062	Mouse Rat Fly
t helper 1 type immune response	GO:0042088	25	0.061
regulation of metal ion transport	GO:0010959	106	0.061	Mouse
cellular homeostasis	GO:0019725	240	0.060
regulation of leukocyte differentiation	GO:1902105	159	0.058
neutrophil migration	GO:1990266	37	0.058
positive regulation of protein transport	GO:0051222	93	0.058
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.058
actomyosin structure organization	GO:0031032	56	0.058	Mouse
response to molecule of fungal origin	GO:0002238	4	0.057
response to drug	GO:0042493	75	0.057
positive regulation of interleukin 12 production	GO:0032735	21	0.057
regulation of cell migration	GO:0030334	219	0.056	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.056
cellular ketone metabolic process	GO:0042180	84	0.056
dendritic cell differentiation	GO:0097028	26	0.055
regulation of t helper 2 cell cytokine production	GO:2000551	3	0.055
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.054
regulation of cytoplasmic transport	GO:1903649	112	0.054
jnk cascade	GO:0007254	72	0.054
blood circulation	GO:0008015	195	0.054
neutrophil chemotaxis	GO:0030593	36	0.053
cd8 positive alpha beta t cell extravasation	GO:0035697	3	0.053
nitrogen compound transport	GO:0071705	271	0.053
positive regulation of t cell extravasation	GO:2000409	2	0.053
regulation of inflammatory response	GO:0050727	147	0.052
protein localization to nucleus	GO:0034504	121	0.052
cellular ion homeostasis	GO:0006873	165	0.052
establishment of protein localization to organelle	GO:0072594	118	0.052
response to transforming growth factor beta	GO:0071559	88	0.052
axon guidance	GO:0007411	141	0.052
regulation of cellular amino acid metabolic process	GO:0006521	5	0.051
natural killer cell mediated cytotoxicity	GO:0042267	29	0.051
intracellular protein transport	GO:0006886	204	0.051
t cell selection	GO:0045058	34	0.051
divalent inorganic cation homeostasis	GO:0072507	138	0.051	Mouse
protein localization to organelle	GO:0033365	185	0.051
acute inflammatory response	GO:0002526	41	0.051
telencephalon development	GO:0021537	186	0.050
positive regulation of immunological synapse formation	GO:2000522	1	0.050
regulation of immune complex clearance by monocytes and macrophages	GO:0090264	2	0.050
positive regulation of t cell proliferation	GO:0042102	52	0.050
inorganic anion transport	GO:0015698	43	0.050
generation of precursor metabolites and energy	GO:0006091	103	0.049
t cell differentiation in thymus	GO:0033077	77	0.049
positive regulation of monocyte extravasation	GO:2000439	1	0.049
microglial cell activation involved in immune response	GO:0002282	1	0.049
purine nucleotide metabolic process	GO:0006163	302	0.049
regulation of multi organism process	GO:0043900	111	0.049
positive regulation of t cell differentiation	GO:0045582	52	0.049
positive regulation of cytokine secretion	GO:0050715	41	0.048
positive regulation of hydrolase activity	GO:0051345	148	0.048
positive regulation of protein kinase activity	GO:0045860	144	0.048	Mouse
protein targeting	GO:0006605	143	0.047
negative regulation of eosinophil degranulation	GO:0043310	1	0.047
positive regulation of response to wounding	GO:1903036	66	0.047
regulation of t cell costimulation	GO:2000523	2	0.047
positive regulation of homeostatic process	GO:0032846	64	0.047
regulation of myeloid cell apoptotic process	GO:0033032	19	0.046
phospholipid metabolic process	GO:0006644	87	0.046	Mouse
neutrophil differentiation	GO:0030223	3	0.046
b cell proliferation	GO:0042100	53	0.046
negative regulation of cell proliferation	GO:0008285	296	0.046
regulation of gliogenesis	GO:0014013	50	0.046
regulation of cellular catabolic process	GO:0031329	242	0.046
regulation of interleukin 1 production	GO:0032652	26	0.046
regulation of lymphocyte differentiation	GO:0045619	107	0.046
striated muscle cell development	GO:0055002	125	0.045	Mouse
innate immune response activating cell surface receptor signaling pathway	GO:0002220	4	0.045
nuclear transport	GO:0051169	139	0.045
regulation of calcium ion transport	GO:0051924	69	0.045	Mouse
regulation of glial cell differentiation	GO:0045685	41	0.045
regulation of mapk cascade	GO:0043408	248	0.044	Mouse Fly
cytokine production involved in immune response	GO:0002367	34	0.044	Mouse
positive regulation of lymphocyte migration	GO:2000403	11	0.044
cell adhesion	GO:0007155	329	0.044	Mouse
antigen processing and presentation	GO:0019882	47	0.044
regulation of inflammatory response to antigenic stimulus	GO:0002861	21	0.044
calcium ion homeostasis	GO:0055074	127	0.044	Mouse
myeloid cell apoptotic process	GO:0033028	22	0.044
regulation of dendritic cell chemotaxis	GO:2000508	1	0.044
extrinsic apoptotic signaling pathway	GO:0097191	126	0.044
regulation of cell motility	GO:2000145	236	0.044	Mouse
tissue remodeling	GO:0048771	102	0.043	Mouse
regulation of immunological synapse formation	GO:2000520	2	0.043
release of sequestered calcium ion into cytosol	GO:0051209	42	0.042
regulation of organelle organization	GO:0033043	289	0.042	Mouse
peptidyl tyrosine modification	GO:0018212	145	0.042
positive regulation of transferase activity	GO:0051347	167	0.042	Mouse
eosinophil activation involved in immune response	GO:0002278	1	0.041
regulation of eosinophil degranulation	GO:0043309	1	0.041
cellular response to dna damage stimulus	GO:0006974	207	0.041	Fly
nucleotide metabolic process	GO:0009117	332	0.041
plasma membrane organization	GO:0007009	90	0.041
microglial cell activation	GO:0001774	3	0.041
macromolecule catabolic process	GO:0009057	281	0.041
regulation of monocyte extravasation	GO:2000437	2	0.041
stress activated protein kinase signaling cascade	GO:0031098	81	0.040
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	68	0.040
positive regulation of t cell receptor signaling pathway	GO:0050862	4	0.040
carbohydrate metabolic process	GO:0005975	230	0.040
fertilization	GO:0009566	127	0.040
regulation of lymphocyte mediated immunity	GO:0002706	84	0.040
skeletal muscle fiber development	GO:0048741	58	0.039
positive regulation of cellular catabolic process	GO:0031331	148	0.039
positive regulation of t cell costimulation	GO:2000525	2	0.039
positive regulation of interferon alpha production	GO:0032727	4	0.039
membrane depolarization	GO:0051899	64	0.039
regulation of cd8 positive alpha beta t cell extravasation	GO:2000449	3	0.039
organelle assembly	GO:0070925	177	0.039	Mouse
regulation of t cell extravasation	GO:2000407	3	0.039
wnt signaling pathway	GO:0016055	188	0.039
interspecies interaction between organisms	GO:0044419	83	0.038
actin filament organization	GO:0007015	113	0.038	Fly
regulation of alpha beta t cell activation	GO:0046634	53	0.038
regulation of blood circulation	GO:1903522	93	0.038
t cell migration	GO:0072678	19	0.038
cell growth	GO:0016049	130	0.038
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.037	Mouse
negative regulation of cellular component organization	GO:0051129	194	0.037
negative regulation of cytokine production	GO:0001818	84	0.037
positive regulation of inflammatory response	GO:0050729	47	0.037
positive regulation of hematopoietic stem cell migration	GO:2000473	1	0.037
regulation of stress activated mapk cascade	GO:0032872	69	0.037
purine containing compound metabolic process	GO:0072521	311	0.036
positive regulation of kinase activity	GO:0033674	155	0.036	Mouse
negative regulation of leukocyte apoptotic process	GO:2000107	31	0.036
sodium ion transport	GO:0006814	73	0.036
monocarboxylic acid metabolic process	GO:0032787	191	0.036
cellular metal ion homeostasis	GO:0006875	151	0.036
tissue homeostasis	GO:0001894	115	0.036	Mouse
interleukin 8 production	GO:0032637	4	0.035
detection of fungus	GO:0016046	2	0.035
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.035
lymphocyte activation involved in immune response	GO:0002285	93	0.035
regulation of hydrolase activity	GO:0051336	246	0.035
pallium development	GO:0021543	120	0.035
nucleobase containing small molecule metabolic process	GO:0055086	352	0.034
learning	GO:0007612	98	0.034
regulation of vasculature development	GO:1901342	88	0.034	Mouse
lymphocyte migration	GO:0072676	26	0.034
oligodendrocyte differentiation	GO:0048709	53	0.034
negative regulation of phosphorylation	GO:0042326	166	0.034
cell maturation	GO:0048469	127	0.034	Mouse
osteoclast differentiation	GO:0030316	62	0.033	Mouse
positive regulation of natural killer cell mediated immunity	GO:0002717	16	0.033
gland development	GO:0048732	330	0.033	Mouse Fly
regulation of acute inflammatory response	GO:0002673	27	0.033
cellular response to hormone stimulus	GO:0032870	150	0.033	Mouse Rat Fly
positive regulation of activation of membrane attack complex	GO:0001970	2	0.033
cellular amine metabolic process	GO:0044106	44	0.033
positive regulation of jnk cascade	GO:0046330	46	0.032
developmental cell growth	GO:0048588	84	0.032
organophosphate catabolic process	GO:0046434	232	0.032
immune complex clearance by monocytes and macrophages	GO:0002436	2	0.032
muscle cell differentiation	GO:0042692	261	0.032	Mouse
protein maturation	GO:0051604	176	0.032
cellular glucan metabolic process	GO:0006073	32	0.032
regulation of neutrophil chemotaxis	GO:0090022	14	0.032
negative regulation of protein metabolic process	GO:0051248	282	0.032
positive regulation of calcium ion transport	GO:0051928	27	0.032	Mouse
regulation of secretion	GO:0051046	274	0.031
glucose transport	GO:0015758	56	0.031
negative regulation of leukocyte mediated immunity	GO:0002704	29	0.031
single organism nuclear import	GO:1902593	95	0.031
positive regulation of thymocyte migration	GO:2000412	2	0.031
stress activated mapk cascade	GO:0051403	80	0.031
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.031	Mouse Fly
skeletal muscle organ development	GO:0060538	163	0.031
erk1 and erk2 cascade	GO:0070371	77	0.030	Mouse
regulation of humoral immune response	GO:0002920	22	0.030
heart process	GO:0003015	94	0.030
ribonucleotide metabolic process	GO:0009259	291	0.030
regulation of myeloid cell differentiation	GO:0045637	96	0.030
ribose phosphate metabolic process	GO:0019693	291	0.029
cellular response to growth factor stimulus	GO:0071363	197	0.029	Mouse
interleukin 1 secretion	GO:0050701	16	0.029
digestive system development	GO:0055123	200	0.029	Mouse Fly
oxidation reduction process	GO:0055114	342	0.029
organelle fission	GO:0048285	170	0.029	Mouse
positive regulation of cellular component biogenesis	GO:0044089	94	0.029
anion transport	GO:0006820	177	0.029
response to reactive oxygen species	GO:0000302	56	0.029
positive regulation of cellular amine metabolic process	GO:0033240	5	0.029
reactive oxygen species biosynthetic process	GO:1903409	8	0.028
branching morphogenesis of an epithelial tube	GO:0048754	159	0.028	Mouse
positive regulation of oligodendrocyte differentiation	GO:0048714	9	0.028
cell surface pattern recognition receptor signaling pathway	GO:0002752	2	0.028
purinergic nucleotide receptor signaling pathway	GO:0035590	3	0.028
protein modification by small protein conjugation	GO:0032446	187	0.028
negative regulation of phosphorus metabolic process	GO:0010563	184	0.028
t cell receptor signaling pathway	GO:0050852	46	0.028
locomotory behavior	GO:0007626	195	0.028
negative regulation of molecular function	GO:0044092	258	0.028
regulation of cytoskeleton organization	GO:0051493	122	0.028	Mouse
positive regulation of ion transport	GO:0043270	65	0.028	Mouse
inflammatory response to antigenic stimulus	GO:0002437	30	0.028
peptidyl amino acid modification	GO:0018193	336	0.028
cellular chemical homeostasis	GO:0055082	215	0.028
natural killer cell mediated immunity	GO:0002228	29	0.028
activation of mapk activity	GO:0000187	59	0.028
protein import into nucleus	GO:0006606	95	0.027
purine ribonucleoside metabolic process	GO:0046128	241	0.027
carboxylic acid biosynthetic process	GO:0046394	86	0.027
regulation of granulocyte chemotaxis	GO:0071622	17	0.027
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.027
hematopoietic progenitor cell differentiation	GO:0002244	143	0.027
immune complex clearance	GO:0002434	2	0.027
inflammatory cell apoptotic process	GO:0006925	11	0.027
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.027
positive regulation of behavior	GO:0048520	40	0.027	Mouse
positive regulation of intracellular transport	GO:0032388	70	0.027
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.027
regulation of jnk cascade	GO:0046328	62	0.027
urogenital system development	GO:0001655	261	0.027	Mouse Fly
response to oxidative stress	GO:0006979	123	0.027
multicellular organism growth	GO:0035264	161	0.027
purine nucleoside metabolic process	GO:0042278	241	0.026
spermatogenesis	GO:0007283	284	0.026	Mouse
cellular nitrogen compound catabolic process	GO:0044270	280	0.026
cellular response to molecule of fungal origin	GO:0071226	2	0.026
regulation of intracellular protein transport	GO:0033157	82	0.026
positive regulation of cardiac muscle cell apoptotic process	GO:0010666	3	0.026
positive regulation of glial cell differentiation	GO:0045687	21	0.026
fatty acid biosynthetic process	GO:0006633	41	0.026
regulation of eosinophil migration	GO:2000416	2	0.026
myotube differentiation	GO:0014902	105	0.025
negative regulation of lymphocyte proliferation	GO:0050672	45	0.025
regulation of bone remodeling	GO:0046850	28	0.025
regulation of purine nucleotide metabolic process	GO:1900542	169	0.025
bone resorption	GO:0045453	38	0.025
granulocyte differentiation	GO:0030851	17	0.025
energy derivation by oxidation of organic compounds	GO:0015980	77	0.025
regulation of thymocyte migration	GO:2000410	2	0.025
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.025
nucleoside phosphate metabolic process	GO:0006753	338	0.025
positive regulation of proteolysis	GO:0045862	85	0.025
regulation of actin filament based process	GO:0032970	99	0.025	Mouse
regulation of angiogenesis	GO:0045765	81	0.025	Mouse
positive regulation of inflammatory response to antigenic stimulus	GO:0002863	11	0.025
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002823	23	0.025
regulation of tumor necrosis factor biosynthetic process	GO:0042534	10	0.024
positive regulation of vasoconstriction	GO:0045907	4	0.024

Flt3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
disease by infectious agent	DOID:0050117	0.313
viral infectious disease	DOID:934	0.313
acquired immunodeficiency syndrome	DOID:635	0.192
human immunodeficiency virus infectious disease	DOID:526	0.192
disease of anatomical entity	DOID:7	0.076
immune system disease	DOID:2914	0.076
cancer	DOID:162	0.038	Human
disease of cellular proliferation	DOID:14566	0.038	Human
nervous system disease	DOID:863	0.035
central nervous system disease	DOID:331	0.035
organ system cancer	DOID:0050686	0.026	Human

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