Mus musculus

79 known processes

Spen

SPEN homolog, transcriptional regulator (Drosophila)

(Aliases: mKIAA0929,Mint)

Spen biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
internal protein amino acid acetylationGO:0006475420.292
covalent chromatin modificationGO:00165691630.288
chromatin modificationGO:00165681870.209
histone h3 acetylationGO:0043966140.193
chromatin organizationGO:00063252060.166
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296820.146
internal peptidyl lysine acetylationGO:0018393420.136
positive regulation of dna templated transcription elongationGO:003278620.131
peptidyl lysine modificationGO:0018205770.116
histone acetylationGO:0016573410.110
cell fate commitmentGO:00451652100.108
Fly
histone modificationGO:00165701590.099
embryonic organ morphogenesisGO:00485622760.093
regulation of histone h3 k4 methylationGO:0051569120.088
nucleoside metabolic processGO:00091162460.085
regionalizationGO:00030023370.084
Fly
regulation of cell cycleGO:00517262810.082
negative regulation of cell proliferationGO:00082852960.074
peptidyl amino acid modificationGO:00181933360.073
protein acylationGO:0043543640.072
cellular ketone metabolic processGO:0042180840.070
regulation of histone methylationGO:0031060300.067
neural precursor cell proliferationGO:00613511210.065
peptidyl lysine acetylationGO:0018394450.065
histone h4 k16 acetylationGO:004398430.062
stem cell proliferationGO:00720891170.062
organic cyclic compound catabolic processGO:19013612950.061
ribonucleoside triphosphate catabolic processGO:00092031990.061
negative regulation of protein metabolic processGO:00512482820.058
purine nucleotide metabolic processGO:00061633020.057
nucleoside catabolic processGO:00091642060.055
axonogenesisGO:00074092740.055
Fly
purine nucleoside metabolic processGO:00422782410.054
regulation of transcription during meiosisGO:005103710.054
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.051
Fly
respiratory tube developmentGO:00303231670.050
methylationGO:00322591340.049
purine ribonucleotide metabolic processGO:00091502900.049
neuron projection guidanceGO:00974851410.048
Fly
regulation of histone modificationGO:0031056560.048
wnt signaling pathwayGO:00160551880.047
Fly
nucleotide catabolic processGO:00091662170.046
protein methylationGO:0006479810.043
heterocycle catabolic processGO:00467002800.043
purine ribonucleoside metabolic processGO:00461282410.043
microtubule based processGO:00070172360.042
purine ribonucleoside triphosphate metabolic processGO:00092052200.042
regulation of chromatin modificationGO:1903308570.042
histone lysine methylationGO:0034968500.042
macromolecule methylationGO:00434141200.041
leukocyte differentiationGO:00025213420.041
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.041
purine nucleoside catabolic processGO:00061522050.040
purine nucleoside triphosphate metabolic processGO:00091442260.040
rho protein signal transductionGO:0007266320.040
aromatic compound catabolic processGO:00194392860.038
purine containing compound catabolic processGO:00725232130.038
gonad developmentGO:00084061410.037
lung developmentGO:00303241640.037
nucleoside phosphate metabolic processGO:00067533380.037
regulation of organelle organizationGO:00330432890.037
protein alkylationGO:0008213810.036
cellular lipid metabolic processGO:00442553230.036
purine nucleotide catabolic processGO:00061952110.036
negative regulation of molecular functionGO:00440922580.035
ribose phosphate metabolic processGO:00196932910.035
ribonucleotide metabolic processGO:00092592910.035
negative regulation of protein modification processGO:00314001630.034
glycosyl compound metabolic processGO:19016572460.034
lipid biosynthetic processGO:00086101790.034
regulation of cellular catabolic processGO:00313292420.034
regulation of mitotic cell cycleGO:00073461260.033
regulation of cell morphogenesis involved in differentiationGO:00107691510.033
purine ribonucleotide catabolic processGO:00091542080.033
purine nucleoside triphosphate catabolic processGO:00091462030.033
purine containing compound metabolic processGO:00725213110.033
purine ribonucleoside triphosphate catabolic processGO:00092071990.033
regulation of membrane potentialGO:00423911920.033
nucleobase containing small molecule metabolic processGO:00550863520.032
nucleoside triphosphate metabolic processGO:00091412300.031
cellular homeostasisGO:00197252400.030
regulation of bindingGO:00510981110.030
forebrain developmentGO:00309003020.030
myotube differentiationGO:00149021050.030
organonitrogen compound catabolic processGO:19015652640.030
ribonucleoside metabolic processGO:00091192450.029
carbohydrate derivative catabolic processGO:19011362310.029
regulation of neuron differentiationGO:00456642810.029
negative regulation of cellular protein metabolic processGO:00322692470.029
monosaccharide metabolic processGO:00059961060.029
lymphocyte differentiationGO:00300982420.028
positive regulation of nucleoside metabolic processGO:0045979910.028
cellular amino acid metabolic processGO:00065201030.028
rhythmic processGO:00485111740.027
nucleotide metabolic processGO:00091173320.027
regulation of chromosome organizationGO:0033044830.027
male gamete generationGO:00482322850.027
immune effector processGO:00022523210.027
response to organonitrogen compoundGO:00102432460.027
dephosphorylationGO:00163111290.027
cellular response to dna damage stimulusGO:00069742070.026
regulation of cellular ketone metabolic processGO:0010565660.026
lung alveolus developmentGO:0048286450.026
histone methylationGO:0016571710.026
guanosine containing compound metabolic processGO:19010681440.026
histone h3 k4 trimethylationGO:008018250.026
positive regulation of neuron differentiationGO:00456661410.026
hindbrain developmentGO:00309021280.025
mitotic cell cycle processGO:19030471590.025
regulation of cellular response to stressGO:00801351590.025
regulation of cell cycle processGO:00105641600.025
multicellular organismal signalingGO:0035637910.025
protein catabolic processGO:00301632210.024
ras protein signal transductionGO:0007265770.024
ovarian follicle developmentGO:0001541400.023
nucleoside triphosphate catabolic processGO:00091432050.023
rna processingGO:00063961050.023
stem cell differentiationGO:00488632680.023
Fly
negative regulation of triglyceride metabolic processGO:009020940.023
skeletal system morphogenesisGO:00487052030.023
asymmetric stem cell divisionGO:009872230.022
cellular nitrogen compound catabolic processGO:00442702800.022
glycosyl compound catabolic processGO:19016582060.022
organophosphate catabolic processGO:00464342320.022
cytoplasmic transportGO:00164822340.022
transmission of nerve impulseGO:0019226760.022
cation homeostasisGO:00550802120.022
regulation of purine nucleotide catabolic processGO:00331211220.022
microtubule cytoskeleton organizationGO:00002261570.021
ribonucleotide catabolic processGO:00092612080.021
camera type eye developmentGO:00430102660.021
nucleoside phosphate catabolic processGO:19012922220.021
acylglycerol biosynthetic processGO:0046463180.021
carbohydrate metabolic processGO:00059752300.021
negative regulation of cell cycle processGO:0010948690.021
skeletal system developmentGO:00015013560.021
cellular macromolecule catabolic processGO:00442652060.021
regulation of cell motilityGO:20001452360.021
anion transportGO:00068201770.021
blood vessel morphogenesisGO:00485142850.021
Mouse
positive regulation of nervous system developmentGO:00519622210.021
Human
cellular response to organonitrogen compoundGO:00714171450.020
gtp catabolic processGO:00061841430.020
second messenger mediated signalingGO:0019932730.020
regulation of mrna processingGO:0050684410.020
regulation of sequence specific dna binding transcription factor activityGO:00510901060.020
muscle tissue developmentGO:00605373080.020
negative regulation of cell cycleGO:00457861230.020
purine ribonucleoside catabolic processGO:00461302050.020
bone developmentGO:00603481200.019
lens development in camera type eyeGO:0002088620.019
negative regulation of mesenchymal cell proliferationGO:007220130.019
positive regulation of cellular amino acid metabolic processGO:004576430.019
jak stat cascadeGO:0007259420.019
regulation of leukocyte differentiationGO:19021051590.019
adult behaviorGO:00305341350.019
protein localization to organelleGO:00333651850.019
spermatogenesisGO:00072832840.019
striated muscle tissue developmentGO:00147062930.019
regulation of nucleotide metabolic processGO:00061401690.019
negative regulation of phosphorus metabolic processGO:00105631840.019
sequestering of calcium ionGO:0051208180.019
regulation of stem cell proliferationGO:0072091780.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.019
compound eye developmentGO:004874910.019
Fly
cellular chemical homeostasisGO:00550822150.019
protein localization to cell junctionGO:190241430.019
macromolecule catabolic processGO:00090572810.019
myeloid cell differentiationGO:00300992330.019
Mouse
compartment pattern specificationGO:000738640.018
mitotic cell cycleGO:00002781950.018
gene silencingGO:0016458380.018
ribonucleoside catabolic processGO:00424542060.018
chemotaxisGO:00069352470.018
Fly
positive regulation of protein phosphorylationGO:00019342420.018
zygotic determination of anterior posterior axis embryoGO:000735430.018
homeostasis of number of cellsGO:00488722100.018
rna splicingGO:0008380540.018
ear developmentGO:00435832000.018
cellular amine metabolic processGO:0044106440.018
development of primary female sexual characteristicsGO:0046545730.018
triglyceride biosynthetic processGO:0019432170.018
organelle localizationGO:00516401790.018
development of primary sexual characteristicsGO:00451371430.018
endocytosisGO:00068971680.017
telencephalon developmentGO:00215371860.017
dna methylationGO:0006306430.017
negative regulation of triglyceride biosynthetic processGO:001086820.017
locomotory behaviorGO:00076261950.017
transmembrane transportGO:00550854120.017
nuclear divisionGO:00002801580.017
ribonucleoside monophosphate metabolic processGO:0009161800.017
germ cell developmentGO:00072811850.017
protein autophosphorylationGO:0046777610.017
cellular carbohydrate metabolic processGO:00442621190.017
cellular ion homeostasisGO:00068731650.017
axon guidanceGO:00074111410.017
Fly
amine metabolic processGO:0009308450.016
dna alkylationGO:0006305430.016
mapk cascadeGO:00001652810.016
sensory organ morphogenesisGO:00905962420.016
exocytosisGO:00068871210.016
regulation of secretion by cellGO:19035302490.016
atp metabolic processGO:0046034750.016
regulation of wnt signaling pathwayGO:00301111230.016
Fly
protein modification by small protein conjugationGO:00324461870.016
regulation of lipid metabolic processGO:00192161180.016
carboxylic acid biosynthetic processGO:0046394860.016
mrna metabolic processGO:0016071840.016
organelle fissionGO:00482851700.016
response to molecule of bacterial originGO:00022371430.016
ribonucleoside triphosphate metabolic processGO:00091992200.016
regulation of rho protein signal transductionGO:0035023710.016
histone h4 k12 acetylationGO:004398320.016
regulation of protein localizationGO:00328802310.016
asymmetric neuroblast divisionGO:005505910.016
circadian rhythmGO:00076231140.016
cartilage developmentGO:00512161400.016
histone h4 acetylationGO:0043967100.016
response to peptide hormoneGO:00434341270.016
sensory perceptionGO:00076002450.016
regulation of response to drugGO:200102320.016
cell adhesionGO:00071553290.016
platelet derived growth factor receptor alpha signaling pathwayGO:003579030.015
positive regulation of neuron projection developmentGO:0010976790.015
inflammatory responseGO:00069542440.015
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377430.015
circulatory system processGO:00030131970.015
negative regulation of homeostatic processGO:0032845710.015
positive regulation of cell projection organizationGO:0031346950.015
metal ion homeostasisGO:00550651890.015
positive regulation of mapk cascadeGO:00434101700.015
regulation of cellular carbohydrate metabolic processGO:0010675750.015
epithelial cell developmentGO:00020641590.015
cardiac muscle cell differentiationGO:0055007690.015
mrna transcription from rna polymerase ii promoterGO:004278940.015
response to organic cyclic compoundGO:00140701980.015
synaptic transmissionGO:00072683290.015
nitrogen compound transportGO:00717052710.015
sequestering of metal ionGO:0051238190.015
dna modificationGO:0006304500.015
blastocyst developmentGO:0001824800.015
stem cell developmentGO:00488642190.015
regulation of homeostatic processGO:00328441820.015
gtp metabolic processGO:00460391440.015
negative regulation of cell cycle phase transitionGO:1901988480.015
positive regulation of bindingGO:0051099490.015
cation transportGO:00068123990.015
regulation of protein serine threonine kinase activityGO:00719001570.015
peptidyl lysine trimethylationGO:0018023120.015
positive regulation of cell migrationGO:00303351090.014
histone h3 k14 acetylationGO:004415430.014
cellular response to peptide hormone stimulusGO:0071375920.014
blastocyst growthGO:0001832230.014
regulation of vesicle mediated transportGO:00606271390.014
establishment of organelle localizationGO:00516561220.014
regulation of mapk cascadeGO:00434082480.014
single organismal cell cell adhesionGO:00163371310.014
connective tissue developmentGO:00614481790.014
appendage morphogenesisGO:00351071490.014
Fly
proteasomal protein catabolic processGO:0010498980.014
ameboidal type cell migrationGO:00016671280.014
sensory perception of mechanical stimulusGO:00509541070.014
neuron migrationGO:00017641220.014
regulation of protein processingGO:0070613960.014
regulation of cellular amino acid metabolic processGO:000652150.014
canonical wnt signaling pathwayGO:00600701300.014
purine nucleoside monophosphate catabolic processGO:0009128580.014
action potentialGO:0001508780.014
negative regulation of protein maturationGO:1903318790.014
response to peptideGO:19016521360.014
regulation of chromatin organizationGO:1902275570.014
positive regulation of purine nucleotide metabolic processGO:19005441140.014
regulation of lymphocyte anergyGO:000291140.014
cellular response to ethanolGO:007136130.014
stress activated mapk cascadeGO:0051403800.013
negative regulation of platelet derived growth factor receptor alpha signaling pathwayGO:200058420.013
fat cell differentiationGO:00454441600.013
regulation of fibroblast proliferationGO:0048145340.013
regulation of hydrolase activityGO:00513362460.013
regulation of mrna splicing via spliceosomeGO:0048024320.013
cellularizationGO:000734910.013
retrograde transport endosome to golgiGO:004214720.013
defecationGO:003042110.013
organic acid biosynthetic processGO:0016053860.013
male meiosis iGO:0007141160.013
neuroblast differentiationGO:001401620.013
Fly
t cell differentiationGO:00302171740.013
negative regulation of phosphate metabolic processGO:00459361840.013
nucleoside monophosphate catabolic processGO:0009125590.013
organ growthGO:00352651170.013
translationGO:0006412930.013
gland developmentGO:00487323300.013
positive regulation of apoptotic processGO:00430652170.013
positive regulation of cellular amine metabolic processGO:003324050.013
carbohydrate homeostasisGO:00335001280.013
memoryGO:0007613580.013
embryonic hemopoiesisGO:0035162230.013
cartilage development involved in endochondral bone morphogenesisGO:0060351240.013
male meiosisGO:0007140370.013
nucleocytoplasmic transportGO:00069131390.013
kidney developmentGO:00018222130.013
guanosine containing compound catabolic processGO:19010691440.013
negative regulation of immune system processGO:00026832090.013
Mouse
response to insulinGO:00328681000.013
neutral lipid biosynthetic processGO:0046460180.013
g1 s transition of mitotic cell cycleGO:0000082570.012
hexose biosynthetic processGO:0019319390.012
regulation of lipid biosynthetic processGO:0046890540.012
female sex differentiationGO:0046660840.012
regulation of secretionGO:00510462740.012
regulation of transferase activityGO:00513382630.012
regulation of triglyceride biosynthetic processGO:0010866100.012
positive regulation of nucleotide metabolic processGO:00459811140.012
respiratory system developmentGO:00605411900.012
renal system developmentGO:00720012250.012
neuronal action potentialGO:0019228540.012
ribonucleoside monophosphate catabolic processGO:0009158570.012
positive regulation of programmed cell deathGO:00430682180.012
regulation of mrna metabolic processGO:1903311430.012
cellular protein catabolic processGO:00442571550.012
purine ribonucleoside monophosphate catabolic processGO:0009169570.012
negative regulation of intracellular signal transductionGO:19025321670.012
neuroblast fate commitmentGO:001401710.012
Fly
spermatid differentiationGO:00485151150.012
regulation of neuron projection developmentGO:00109751690.012
regulation of dna bindingGO:0051101390.012
regulation of intracellular transportGO:00323861590.012
embryonic genitalia morphogenesisGO:003053840.012
carbohydrate biosynthetic processGO:0016051740.012
regulation of mitotic cell cycle phase transitionGO:1901990730.012
modification dependent macromolecule catabolic processGO:00436321330.012
t cell activationGO:00421102890.012
cardiac muscle tissue developmentGO:00487381300.012
regulation of cell projection organizationGO:00313442060.012
regulation of purine nucleotide metabolic processGO:19005421690.012
mrna processingGO:0006397630.012
female gamete generationGO:0007292740.012
rna interferenceGO:001624620.012
regulation of striated muscle cell differentiationGO:0051153810.012
small molecule biosynthetic processGO:00442831320.012
histone h3 k4 methylationGO:0051568230.012
purine ribonucleoside monophosphate metabolic processGO:0009167800.012
nucleoside monophosphate metabolic processGO:0009123850.012
regulation of protein bindingGO:0043393600.012
regulation of fat cell differentiationGO:0045598810.012
positive regulation of protein modification processGO:00314012990.012
cellular response to hormone stimulusGO:00328701500.011
regulation of protein maturationGO:1903317960.011
regulation of translationGO:0006417710.011
muscle system processGO:00030121410.011
protein modification by small protein conjugation or removalGO:00706472070.011
regulation of transforming growth factor beta receptor signaling pathwayGO:0017015430.011
cell divisionGO:00513011200.011
epithelial tube morphogenesisGO:00605623030.011
Mouse
regulation of cell activationGO:00508652890.011
peptide transportGO:00158331330.011
limb morphogenesisGO:00351081490.011
alpha beta t cell differentiationGO:0046632690.011
g protein coupled receptor signaling pathwayGO:00071862430.011
primary neural tube formationGO:0014020950.011
cellular metal ion homeostasisGO:00068751510.011
regulation of reactive oxygen species biosynthetic processGO:190342620.011
monocarboxylic acid metabolic processGO:00327871910.011
nuclear transportGO:00511691390.011
central nervous system neuron differentiationGO:00219531620.011
monosaccharide biosynthetic processGO:0046364440.011
purine nucleoside monophosphate metabolic processGO:0009126810.011
glucose homeostasisGO:00425931280.011
regulation of cell adhesionGO:00301551540.011
myeloid leukocyte differentiationGO:00025731190.011
positive regulation of cell developmentGO:00107202370.011
Human
gliogenesisGO:00420631410.011
Fly
response to radiationGO:00093141650.011
intracellular protein transportGO:00068862040.011
inner cell mass cell proliferationGO:0001833150.011
regulation of system processGO:00440572000.011
epithalamus developmentGO:002153820.011
limb developmentGO:00601731660.011
positive regulation of purine nucleotide catabolic processGO:0033123880.011
cytokine productionGO:00018163190.011
digestive tract developmentGO:00485651900.011
actin filament organizationGO:00070151130.011
neuroblast proliferationGO:0007405490.011
cell proliferation in forebrainGO:0021846300.011
cell type specific apoptotic processGO:00972852680.011
negative regulation of cell developmentGO:00107211690.011
establishment of planar polarityGO:0001736280.011
Fly
glycerolipid biosynthetic processGO:0045017500.011
regulation of response to woundingGO:19030341890.011
mitotic cytokinesisGO:000028140.011
heart morphogenesisGO:00030071780.011
Mouse
posttranscriptional regulation of gene expressionGO:00106081550.011
smoothened signaling pathwayGO:00072241050.011
regulation of ion transportGO:00432692150.011
urogenital system developmentGO:00016552610.011
glycerolipid metabolic processGO:00464861220.010
regulation of stress activated mapk cascadeGO:0032872690.010
monocarboxylic acid biosynthetic processGO:0072330610.010
response to extracellular stimulusGO:00099911270.010
calcium ion homeostasisGO:00550741270.010
protein localization to nucleusGO:00345041210.010
dna metabolic processGO:00062593030.010
chromatin remodelingGO:0006338320.010
regulation of extent of cell growthGO:0061387520.010
negative regulation of sequence specific dna binding transcription factor activityGO:0043433400.010
appendage developmentGO:00487361660.010
Fly
ion transmembrane transportGO:00342203610.010
regulation of hippo signalingGO:003533010.010
negative regulation of organelle organizationGO:0010639900.010
smad protein signal transductionGO:0060395210.010
i kappab kinase nf kappab signalingGO:0007249850.010
regulation of cell migrationGO:00303342190.010
response to light stimulusGO:00094161350.010
regulation of rna splicingGO:0043484370.010
multi multicellular organism processGO:00447061090.010
regulation of lamellipodium assemblyGO:001059130.010
small gtpase mediated signal transductionGO:0007264970.010
muscle cell differentiationGO:00426922610.010
oocyte axis specificationGO:000730920.010
organic anion transportGO:00157111370.010
spleen developmentGO:0048536390.010
Mouse

Spen disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.041
disease of anatomical entityDOID:700.041
disease of mental healthDOID:15000.014
musculoskeletal system diseaseDOID:1700.013
hematopoietic system diseaseDOID:7400.013
immune system diseaseDOID:291400.013
disease of cellular proliferationDOID:1456600.012
cancerDOID:16200.012
hematologic cancerDOID:253100.012
organ system cancerDOID:005068600.012
immune system cancerDOID:006008300.012
central nervous system diseaseDOID:33100.011
neurodegenerative diseaseDOID:128900.011