IMP: Integrative Multi-species Prediction

Mus musculus

62 known processes

Xcr1

chemokine (C motif) receptor 1

(Aliases: Ccxcr1,GPR5)

Entrez: 23832
Ensembl: ENSMUSG00000060509
UniProtKB: S4R1K3
UniProtKB: Q544D8

Process Predictions
Disease Predictions

Xcr1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
immune response activating signal transduction	GO:0002757	116	0.804	Mouse
positive regulation of monocyte extravasation	GO:2000439	1	0.801	Mouse
regulation of hematopoietic stem cell migration	GO:2000471	1	0.800	Mouse
negative regulation of eosinophil degranulation	GO:0043310	1	0.795	Mouse
positive regulation of t cell costimulation	GO:2000525	2	0.791	Mouse
hematopoietic stem cell migration	GO:0035701	1	0.791	Mouse
positive regulation of immunological synapse formation	GO:2000522	1	0.764	Mouse
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.756	Mouse
regulation of monocyte chemotaxis	GO:0090025	3	0.742	Mouse
positive regulation of t cell receptor signaling pathway	GO:0050862	4	0.692	Mouse
t cell extravasation	GO:0072683	4	0.685	Mouse
regulation of immunological synapse formation	GO:2000520	2	0.644	Mouse
eosinophil activation	GO:0043307	1	0.634	Mouse
regulation of t cell costimulation	GO:2000523	2	0.627	Mouse
regulation of eosinophil degranulation	GO:0043309	1	0.626	Mouse
eosinophil activation involved in immune response	GO:0002278	1	0.620	Mouse
response to molecule of bacterial origin	GO:0002237	143	0.617	Mouse
activation of immune response	GO:0002253	138	0.614	Mouse
monocyte extravasation	GO:0035696	2	0.612	Mouse
mature dendritic cell differentiation	GO:0097029	3	0.609	Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.588	Mouse
defense response to other organism	GO:0098542	197	0.565
immune effector process	GO:0002252	321	0.551	Mouse
helper t cell chemotaxis	GO:0035704	1	0.548	Mouse
positive regulation of cytokine production	GO:0001819	174	0.542	Mouse
regulation of monocyte extravasation	GO:2000437	2	0.533	Mouse
defense response to bacterium	GO:0042742	119	0.532
leukocyte mediated immunity	GO:0002443	174	0.522	Mouse
g protein coupled receptor signaling pathway	GO:0007186	243	0.515	Mouse
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.492	Mouse
regulation of cd8 positive alpha beta t cell extravasation	GO:2000449	3	0.492	Mouse
cd8 positive alpha beta t cell extravasation	GO:0035697	3	0.484	Mouse
t helper 17 cell chemotaxis	GO:0035705	1	0.480	Mouse
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.477	Mouse
positive regulation of immune complex clearance by monocytes and macrophages	GO:0090265	2	0.462	Mouse
cytokine mediated signaling pathway	GO:0019221	115	0.461	Mouse
positive regulation of defense response	GO:0031349	124	0.448	Mouse
innate immune response	GO:0045087	157	0.442	Mouse
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation	GO:2000526	1	0.430	Mouse
regulation of leukocyte mediated immunity	GO:0002703	104	0.426	Mouse
antigen processing and presentation	GO:0019882	47	0.421	Mouse
multicellular organismal signaling	GO:0035637	91	0.402
regulation of cytokine production	GO:0001817	266	0.402	Mouse
leukocyte activation involved in immune response	GO:0002366	126	0.388	Mouse
defense response to gram positive bacterium	GO:0050830	50	0.387
regulation of adaptive immune response	GO:0002819	90	0.383	Mouse
cation transport	GO:0006812	399	0.381
positive regulation of secretion	GO:0051047	130	0.377
positive regulation of t cell extravasation	GO:2000409	2	0.375	Mouse
regulation of inflammatory response to antigenic stimulus	GO:0002861	21	0.375	Mouse
cation homeostasis	GO:0055080	212	0.363
positive regulation of hematopoietic stem cell migration	GO:2000473	1	0.351	Mouse
inflammatory response	GO:0006954	244	0.349	Mouse
regulation of t cell activation	GO:0050863	170	0.345	Mouse
positive regulation of acute inflammatory response	GO:0002675	16	0.343	Mouse
regulation of homeostatic process	GO:0032844	182	0.341
lymphocyte proliferation	GO:0046651	164	0.337	Mouse
microglial cell activation	GO:0001774	3	0.336	Mouse
regulation of cytokine biosynthetic process	GO:0042035	59	0.333	Mouse
positive regulation of cell motility	GO:2000147	116	0.333	Mouse
alpha beta t cell activation	GO:0046631	91	0.331	Mouse
t cell activation	GO:0042110	289	0.327	Mouse
interleukin 12 secretion	GO:0072610	3	0.327	Mouse
positive regulation of monocyte chemotaxis	GO:0090026	2	0.326	Mouse
positive regulation of dendritic cell chemotaxis	GO:2000510	1	0.320	Mouse
myeloid cell activation involved in immune response	GO:0002275	34	0.320	Mouse
granulocyte chemotaxis	GO:0071621	39	0.313	Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.313	Mouse
myeloid cell differentiation	GO:0030099	233	0.312	Mouse
immune complex clearance by monocytes and macrophages	GO:0002436	2	0.307	Mouse
adaptive immune response	GO:0002250	155	0.305	Mouse
microglial cell activation involved in immune response	GO:0002282	1	0.303	Mouse
positive regulation of cytokine biosynthetic process	GO:0042108	40	0.301	Mouse
regulation of ion homeostasis	GO:2000021	64	0.297
tumor necrosis factor biosynthetic process	GO:0042533	10	0.295	Mouse
regulation of t cell extravasation	GO:2000407	3	0.288	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	183	0.284	Mouse
cellular response to cytokine stimulus	GO:0071345	189	0.283	Mouse
regulation of immune complex clearance by monocytes and macrophages	GO:0090264	2	0.256	Mouse
neutrophil chemotaxis	GO:0030593	36	0.248	Mouse
apoptotic signaling pathway	GO:0097190	306	0.245	Mouse
leukocyte chemotaxis	GO:0030595	69	0.244	Mouse
glycoprotein biosynthetic process	GO:0009101	89	0.243	Mouse
multicellular organismal homeostasis	GO:0048871	164	0.240
immune response regulating signaling pathway	GO:0002764	125	0.239	Mouse
eosinophil degranulation	GO:0043308	1	0.238	Mouse
myeloid leukocyte mediated immunity	GO:0002444	42	0.236	Mouse
thymic t cell selection	GO:0045061	22	0.234	Mouse
cell type specific apoptotic process	GO:0097285	268	0.234	Mouse
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.222
neutrophil migration	GO:1990266	37	0.221	Mouse
myeloid leukocyte migration	GO:0097529	57	0.217	Mouse
regulation of cell activation	GO:0050865	289	0.217	Mouse
regulation of inflammatory response	GO:0050727	147	0.216	Mouse
positive regulation of cell activation	GO:0050867	158	0.212	Mouse
negative regulation of phosphate metabolic process	GO:0045936	184	0.211
eosinophil mediated immunity	GO:0002447	1	0.211	Mouse
positive regulation of immune effector process	GO:0002699	107	0.209	Mouse
regulation of t cell proliferation	GO:0042129	92	0.206	Mouse
divalent metal ion transport	GO:0070838	172	0.204
negative regulation of growth	GO:0045926	99	0.201
alpha beta t cell proliferation	GO:0046633	21	0.200	Mouse
signal transduction in absence of ligand	GO:0038034	55	0.199	Mouse
leukocyte proliferation	GO:0070661	172	0.195	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.195
t cell proliferation	GO:0042098	120	0.192	Mouse
regulation of secretion by cell	GO:1903530	249	0.191	Mouse
regulation of cell motility	GO:2000145	236	0.191	Mouse
regulation of cytokine secretion	GO:0050707	61	0.190	Mouse
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.189	Mouse
regulation of tumor necrosis factor biosynthetic process	GO:0042534	10	0.188	Mouse
cerebral cortex cell migration	GO:0021795	44	0.187	Mouse
positive regulation of interferon gamma production	GO:0032729	39	0.174	Mouse
positive regulation of homeostatic process	GO:0032846	64	0.173
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.172
oligodendrocyte differentiation	GO:0048709	53	0.172	Mouse
regulation of leukocyte proliferation	GO:0070663	121	0.171	Mouse
mapk cascade	GO:0000165	281	0.170
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.168	Mouse
sequestering of calcium ion	GO:0051208	18	0.168
defense response to virus	GO:0051607	68	0.166
cell killing	GO:0001906	67	0.166
positive regulation of antigen receptor mediated signaling pathway	GO:0050857	9	0.165	Mouse
negative thymic t cell selection	GO:0045060	12	0.163	Mouse
regulation of interferon gamma production	GO:0032649	57	0.161	Mouse
negative regulation of immune system process	GO:0002683	209	0.161	Mouse
regulated secretory pathway	GO:0045055	32	0.161	Mouse
metal ion homeostasis	GO:0055065	189	0.154
positive regulation of inflammatory response to antigenic stimulus	GO:0002863	11	0.150	Mouse
positive regulation of cell migration	GO:0030335	109	0.150	Mouse
sequestering of metal ion	GO:0051238	19	0.150
positive regulation of cell killing	GO:0031343	33	0.149
cytokine biosynthetic process	GO:0042089	68	0.148	Mouse
positive regulation of inflammatory response	GO:0050729	47	0.146	Mouse
chemokine mediated signaling pathway	GO:0070098	17	0.146	Mouse
nitrogen compound transport	GO:0071705	271	0.146
regulation of humoral immune response	GO:0002920	22	0.144	Mouse
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.144
forebrain cell migration	GO:0021885	58	0.142	Mouse
cellular extravasation	GO:0045123	17	0.141	Mouse
granulocyte migration	GO:0097530	43	0.140	Mouse
negative regulation of homeostatic process	GO:0032845	71	0.139
lymphocyte migration	GO:0072676	26	0.138	Mouse
calcium ion transport into cytosol	GO:0060402	48	0.137
regulation of vascular endothelial growth factor production	GO:0010574	13	0.136	Mouse
leukocyte differentiation	GO:0002521	342	0.134	Mouse
positive regulation of tumor necrosis factor superfamily cytokine production	GO:1903557	31	0.133	Mouse
protein secretion	GO:0009306	111	0.132	Mouse
t cell selection	GO:0045058	34	0.129	Mouse
response to lipopolysaccharide	GO:0032496	128	0.128	Mouse
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.124
interspecies interaction between organisms	GO:0044419	83	0.123
regulation of establishment of protein localization	GO:0070201	181	0.123	Mouse
positive regulation of tumor necrosis factor production	GO:0032760	30	0.123	Mouse
release of sequestered calcium ion into cytosol	GO:0051209	42	0.123
acute inflammatory response to antigenic stimulus	GO:0002438	12	0.121	Mouse
activation of innate immune response	GO:0002218	56	0.119
hypersensitivity	GO:0002524	10	0.119	Mouse
t cell receptor signaling pathway	GO:0050852	46	0.119	Mouse
positive regulation of interleukin 12 production	GO:0032735	21	0.119	Mouse
neuron projection guidance	GO:0097485	141	0.118	Mouse
immune complex clearance	GO:0002434	2	0.117	Mouse
interleukin 1 production	GO:0032612	31	0.116	Mouse
vascular endothelial growth factor production	GO:0010573	13	0.114	Mouse
regulation of membrane potential	GO:0042391	192	0.114
humoral immune response	GO:0006959	57	0.114	Mouse
detection of yeast	GO:0001879	2	0.113
anatomical structure homeostasis	GO:0060249	145	0.112
inflammatory response to antigenic stimulus	GO:0002437	30	0.112	Mouse
positive regulation of acute inflammatory response to antigenic stimulus	GO:0002866	7	0.111	Mouse
regulation of secretion	GO:0051046	274	0.109	Mouse
regulation of protein secretion	GO:0050708	82	0.109	Mouse
regulation of defense response	GO:0031347	233	0.108	Mouse
positive regulation of granulocyte chemotaxis	GO:0071624	12	0.107	Mouse
cellular calcium ion homeostasis	GO:0006874	119	0.107
positive regulation of chemotaxis	GO:0050921	38	0.107	Mouse
regulation of map kinase activity	GO:0043405	120	0.106
cell activation involved in immune response	GO:0002263	126	0.106	Mouse
cellular ketone metabolic process	GO:0042180	84	0.105
positive regulation of angiogenesis	GO:0045766	46	0.104	Mouse
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.104	Mouse
regulation of kinase activity	GO:0043549	249	0.104
lymphocyte mediated immunity	GO:0002449	139	0.103
leukocyte migration	GO:0050900	124	0.103	Mouse
cell chemotaxis	GO:0060326	81	0.102	Mouse
positive regulation of bone remodeling	GO:0046852	13	0.100
telencephalon cell migration	GO:0022029	55	0.098	Mouse
reactive oxygen species metabolic process	GO:0072593	84	0.096
interferon gamma production	GO:0032609	67	0.096	Mouse
dendritic cell differentiation	GO:0097028	26	0.096	Mouse
regulation of neutrophil chemotaxis	GO:0090022	14	0.096	Mouse
telencephalon development	GO:0021537	186	0.095	Mouse
positive regulation of response to wounding	GO:1903036	66	0.095	Mouse
germ cell development	GO:0007281	185	0.095	Mouse
interleukin 12 production	GO:0032615	32	0.095	Mouse
endocytosis	GO:0006897	168	0.094
negative regulation of cell proliferation	GO:0008285	296	0.094
positive regulation of bone resorption	GO:0045780	13	0.094
cytokine secretion	GO:0050663	72	0.093	Mouse
regulation of hypersensitivity	GO:0002883	10	0.093	Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.091
positive regulation of cellular amine metabolic process	GO:0033240	5	0.091
regulation of lymphocyte proliferation	GO:0050670	117	0.089	Mouse
gliogenesis	GO:0042063	141	0.088	Mouse
regulation of response to wounding	GO:1903034	189	0.088	Mouse
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	54	0.088
maintenance of location	GO:0051235	89	0.086
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.085	Mouse
toll like receptor signaling pathway	GO:0002224	38	0.084
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.083
antigen receptor mediated signaling pathway	GO:0050851	64	0.083	Mouse
cell surface pattern recognition receptor signaling pathway	GO:0002752	2	0.083
regulation of glial cell differentiation	GO:0045685	41	0.083	Mouse
acid secretion	GO:0046717	33	0.082
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.081
muscle tissue development	GO:0060537	308	0.081
positive regulation of ion transport	GO:0043270	65	0.081
i kappab kinase nf kappab signaling	GO:0007249	85	0.081
regulation of cell migration	GO:0030334	219	0.079	Mouse
erk1 and erk2 cascade	GO:0070371	77	0.079
transmission of nerve impulse	GO:0019226	76	0.078
leukocyte degranulation	GO:0043299	27	0.077	Mouse
regulation of vesicle mediated transport	GO:0060627	139	0.077	Mouse
sensory perception of pain	GO:0019233	47	0.077	Mouse
positive regulation of cell death	GO:0010942	224	0.076
regulation of ion transport	GO:0043269	215	0.076
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.076
positive regulation of neutrophil chemotaxis	GO:0090023	12	0.076	Mouse
regulation of lymphocyte activation	GO:0051249	240	0.076	Mouse
stimulatory c type lectin receptor signaling pathway	GO:0002223	2	0.075
cellular homeostasis	GO:0019725	240	0.075
fat cell differentiation	GO:0045444	160	0.074
t cell costimulation	GO:0031295	14	0.074	Mouse
regulation of cellular amino acid metabolic process	GO:0006521	5	0.073
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	52	0.073
regulation of myeloid leukocyte mediated immunity	GO:0002886	25	0.073	Mouse
blood vessel morphogenesis	GO:0048514	285	0.072	Mouse
calcium mediated signaling	GO:0019722	46	0.072
divalent inorganic cation transport	GO:0072511	178	0.072
myeloid leukocyte activation	GO:0002274	83	0.072	Mouse
response to molecule of fungal origin	GO:0002238	4	0.071
regulation of granulocyte chemotaxis	GO:0071622	17	0.071	Mouse
positive regulation of t cell migration	GO:2000406	10	0.071	Mouse
regulation of epithelial cell proliferation	GO:0050678	141	0.071	Mouse
positive regulation of t cell proliferation	GO:0042102	52	0.070	Mouse
regulation of camp metabolic process	GO:0030814	30	0.068
cytokine production	GO:0001816	319	0.068	Mouse
regulation of gliogenesis	GO:0014013	50	0.068	Mouse
regulation of t cell receptor signaling pathway	GO:0050856	21	0.067	Mouse
regulation of interleukin 2 production	GO:0032663	28	0.066	Mouse
regulation of vasculature development	GO:1901342	88	0.066	Mouse
organic acid transport	GO:0015849	101	0.065
calcium ion transport	GO:0006816	159	0.065
negative regulation of defense response	GO:0031348	77	0.065	Mouse
positive regulation of oligodendrocyte differentiation	GO:0048714	9	0.065	Mouse
positive regulation of lymphocyte migration	GO:2000403	11	0.064	Mouse
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.064
activation of mapk activity	GO:0000187	59	0.064
negative regulation of phosphorylation	GO:0042326	166	0.063
bone resorption	GO:0045453	38	0.063
regulation of tumor necrosis factor production	GO:0032680	49	0.062	Mouse
positive regulation of phospholipase c activity	GO:0010863	2	0.062
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.062
cytosolic calcium ion homeostasis	GO:0051480	70	0.062
negative regulation of immune effector process	GO:0002698	55	0.062	Mouse
regulation of interleukin 12 production	GO:0032655	30	0.062	Mouse
regulation of regulated secretory pathway	GO:1903305	20	0.062	Mouse
positive regulation of leukocyte proliferation	GO:0070665	73	0.062	Mouse
positive regulation of cytokine secretion	GO:0050715	41	0.062
regulation of acute inflammatory response to antigenic stimulus	GO:0002864	10	0.062	Mouse
negative regulation of cell activation	GO:0050866	111	0.062	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.061	Mouse
macrophage activation involved in immune response	GO:0002281	7	0.061	Mouse
action potential	GO:0001508	78	0.061
anion transport	GO:0006820	177	0.061
leukocyte mediated cytotoxicity	GO:0001909	62	0.059
positive regulation of innate immune response	GO:0045089	80	0.059
axon guidance	GO:0007411	141	0.058	Mouse
chemotaxis	GO:0006935	247	0.057
tumor necrosis factor production	GO:0032640	50	0.057	Mouse
corticotropin releasing hormone secretion	GO:0043396	2	0.057
positive regulation of regulated secretory pathway	GO:1903307	10	0.056
regulation of chemotaxis	GO:0050920	53	0.056	Mouse
membrane organization	GO:0061024	245	0.056	Mouse
regulation of lymphocyte mediated immunity	GO:0002706	84	0.056
t helper 1 type immune response	GO:0042088	25	0.056	Mouse
lymphocyte activation involved in immune response	GO:0002285	93	0.055
regulation of g protein coupled receptor protein signaling pathway	GO:0008277	37	0.055
regulation of dendritic cell chemotaxis	GO:2000508	1	0.054	Mouse
negative t cell selection	GO:0043383	13	0.054	Mouse
carbohydrate transport	GO:0008643	62	0.054
glial cell differentiation	GO:0010001	131	0.053	Mouse
muscle cell differentiation	GO:0042692	261	0.053
motor neuron axon guidance	GO:0008045	26	0.053	Mouse
microglia differentiation	GO:0014004	2	0.053
monosaccharide transport	GO:0015749	58	0.053
purinergic nucleotide receptor signaling pathway	GO:0035590	3	0.053
cytokine metabolic process	GO:0042107	71	0.053	Mouse
granulocyte activation	GO:0036230	10	0.053	Mouse
negative regulation of multi organism process	GO:0043901	68	0.052
positive regulation of secretion by cell	GO:1903532	114	0.052
regulation of mapk cascade	GO:0043408	248	0.052
positive regulation of neutrophil migration	GO:1902624	12	0.052	Mouse
interleukin 1 beta secretion	GO:0050702	16	0.052	Mouse
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.052	Mouse
positive regulation of alpha beta t cell proliferation	GO:0046641	12	0.052	Mouse
tissue homeostasis	GO:0001894	115	0.051
positive regulation of glycoprotein metabolic process	GO:1903020	6	0.051	Mouse
g protein coupled receptor internalization	GO:0002031	3	0.051
positive regulation of natural killer cell mediated immunity	GO:0002717	16	0.051
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	4	0.051
gastrin induced gastric acid secretion	GO:0001698	1	0.051
icosanoid transport	GO:0071715	14	0.050
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation	GO:2000721	2	0.050
tolerance induction	GO:0002507	14	0.050	Mouse
regulation of phagocytosis	GO:0050764	33	0.050
positive regulation of glial cell differentiation	GO:0045687	21	0.050	Mouse
cellular response to lipopolysaccharide	GO:0071222	77	0.049
glucose transport	GO:0015758	56	0.049
fatty acid derivative transport	GO:1901571	14	0.049
reactive oxygen species biosynthetic process	GO:1903409	8	0.049
positive regulation of reactive oxygen species metabolic process	GO:2000379	11	0.049
cytosolic calcium ion transport	GO:0060401	48	0.049
positive regulation of humoral immune response	GO:0002922	11	0.048	Mouse
regulation of antigen processing and presentation	GO:0002577	10	0.048	Mouse
regulation of innate immune response	GO:0045088	91	0.048	Mouse
forebrain development	GO:0030900	302	0.048	Mouse
t cell mediated immunity	GO:0002456	50	0.048
natural killer cell mediated cytotoxicity	GO:0042267	29	0.047
wnt signaling pathway	GO:0016055	188	0.047
neuron migration	GO:0001764	122	0.047	Mouse
tissue remodeling	GO:0048771	102	0.047
angiogenesis	GO:0001525	201	0.047	Mouse
negative regulation of macrophage apoptotic process	GO:2000110	3	0.046	Mouse
regulation of natural killer cell mediated immunity	GO:0002715	19	0.046
cellular defense response	GO:0006968	6	0.046	Mouse
icosanoid secretion	GO:0032309	12	0.045
regulation of cell killing	GO:0031341	40	0.045
regulation of alpha beta t cell proliferation	GO:0046640	18	0.045	Mouse
regulation of renal sodium excretion	GO:0035813	3	0.045
positive regulation of map kinase activity	GO:0043406	84	0.045
response to extracellular stimulus	GO:0009991	127	0.045
positive regulation of cell development	GO:0010720	237	0.044	Mouse
innate immune response activating cell surface receptor signaling pathway	GO:0002220	4	0.044
pattern recognition receptor signaling pathway	GO:0002221	47	0.044
salivary gland development	GO:0007431	37	0.044
renal sodium excretion	GO:0035812	3	0.043
epithelial tube morphogenesis	GO:0060562	303	0.043	Mouse
positive regulation of t cell activation	GO:0050870	101	0.043	Mouse
response to organonitrogen compound	GO:0010243	246	0.043
regulation of leukocyte mediated cytotoxicity	GO:0001910	38	0.043
regulation of phospholipase c activity	GO:1900274	3	0.043
t cell chemotaxis	GO:0010818	6	0.043	Mouse
morphogenesis of a branching structure	GO:0001763	203	0.042	Mouse
ensheathment of neurons	GO:0007272	76	0.042	Mouse
regulation of interleukin 1 production	GO:0032652	26	0.042	Mouse
cell growth	GO:0016049	130	0.041
regulation of saliva secretion	GO:0046877	2	0.041
regulation of protein transport	GO:0051223	163	0.041	Mouse
regulation of t cell mediated immunity	GO:0002709	34	0.041
interleukin 1 beta production	GO:0032611	30	0.041	Mouse
regulation of acute inflammatory response	GO:0002673	27	0.041	Mouse
cellular response to molecule of bacterial origin	GO:0071219	83	0.041
cellular response to biotic stimulus	GO:0071216	92	0.041
sensory perception	GO:0007600	245	0.040	Mouse
cell cell recognition	GO:0009988	44	0.040	Mouse
regulation of calcium ion transport	GO:0051924	69	0.040
macrophage chemotaxis	GO:0048246	14	0.040	Mouse
regulation of protein localization	GO:0032880	231	0.040	Mouse
positive regulation of glycoprotein biosynthetic process	GO:0010560	6	0.040	Mouse
cognition	GO:0050890	149	0.039
myelination	GO:0042552	74	0.039	Mouse
negative regulation of synapse assembly	GO:0051964	3	0.039
glycoprotein metabolic process	GO:0009100	116	0.039	Mouse
reactive nitrogen species metabolic process	GO:2001057	0	0.039
negative regulation of cytokine production	GO:0001818	84	0.038
positive regulation of protein transport	GO:0051222	93	0.038
cellular amino acid metabolic process	GO:0006520	103	0.038
pallium development	GO:0021543	120	0.038	Mouse
synaptic transmission	GO:0007268	329	0.038
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.037
lymphocyte differentiation	GO:0030098	242	0.037	Mouse
macrophage apoptotic process	GO:0071888	7	0.037	Mouse
carboxylic acid transport	GO:0046942	100	0.037
negative regulation of vasculature development	GO:1901343	26	0.036	Mouse
regulation of bone resorption	GO:0045124	24	0.036
t cell differentiation	GO:0030217	174	0.036	Mouse
innate immune response activating signal transduction	GO:0002758	50	0.036
regulation of leukocyte degranulation	GO:0043300	20	0.035	Mouse
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.035	Mouse
positive regulation of protein secretion	GO:0050714	52	0.035
regulation of leukocyte differentiation	GO:1902105	159	0.034
regulation of metal ion transport	GO:0010959	106	0.034
regulation of system process	GO:0044057	200	0.034
t cell differentiation in thymus	GO:0033077	77	0.033	Mouse
cellular amine metabolic process	GO:0044106	44	0.033
regulation of erk1 and erk2 cascade	GO:0070372	71	0.033
branching morphogenesis of an epithelial tube	GO:0048754	159	0.033	Mouse
cerebral cortex development	GO:0021987	86	0.033	Mouse
positive regulation of epithelial cell proliferation	GO:0050679	68	0.033	Mouse
regulation of tissue remodeling	GO:0034103	38	0.032
leukocyte apoptotic process	GO:0071887	71	0.032	Mouse
lymph node development	GO:0048535	18	0.032	Mouse
macrophage activation	GO:0042116	27	0.032	Mouse
axonogenesis	GO:0007409	274	0.032	Mouse
activation of phospholipase c activity	GO:0007202	2	0.032
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.032	Mouse
regulation of stress activated mapk cascade	GO:0032872	69	0.032
regulation of dendritic cell antigen processing and presentation	GO:0002604	7	0.031	Mouse
positive regulation of jnk cascade	GO:0046330	46	0.031
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.031	Mouse
positive regulation of leukocyte differentiation	GO:1902107	86	0.031
regulation of protein kinase b signaling	GO:0051896	56	0.031
second messenger mediated signaling	GO:0019932	73	0.031
negative regulation of regulated secretory pathway	GO:1903306	7	0.031	Mouse
positive regulation of lymphocyte proliferation	GO:0050671	70	0.031	Mouse
positive regulation of lipid transport	GO:0032370	22	0.031
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.031
peptide hormone secretion	GO:0030072	109	0.030
regulation of transferase activity	GO:0051338	263	0.030
immunological synapse formation	GO:0001771	7	0.030	Mouse
developmental maturation	GO:0021700	193	0.030
positive regulation of interleukin 2 production	GO:0032743	19	0.030	Mouse
natural killer cell activation	GO:0030101	44	0.030
positive regulation of protein kinase b signaling	GO:0051897	32	0.029
regulation of anion transport	GO:0044070	27	0.029
regulation of toll like receptor 4 signaling pathway	GO:0034143	4	0.029
negative regulation of protein metabolic process	GO:0051248	282	0.029
response to interferon gamma	GO:0034341	34	0.029
regulation of protein kinase activity	GO:0045859	232	0.028
cell recognition	GO:0008037	83	0.028	Mouse
peptidyl tyrosine phosphorylation	GO:0018108	143	0.028
positive regulation of gliogenesis	GO:0014015	27	0.028	Mouse
regulation of multi organism process	GO:0043900	111	0.028
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.028
positive regulation of t helper 1 type immune response	GO:0002827	12	0.028	Mouse
metanephros development	GO:0001656	79	0.028
regulation of neutrophil migration	GO:1902622	14	0.028	Mouse
interleukin 1 secretion	GO:0050701	16	0.028	Mouse
response to transforming growth factor beta	GO:0071559	88	0.028
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.027
t cell migration	GO:0072678	19	0.027	Mouse
regulation of alpha beta t cell activation	GO:0046634	53	0.027	Mouse
phagocytosis	GO:0006909	66	0.027
canonical wnt signaling pathway	GO:0060070	130	0.027
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.027
positive regulation of antigen processing and presentation	GO:0002579	10	0.027	Mouse
regulation of glutamate secretion	GO:0014048	3	0.027
negative regulation of angiogenesis	GO:0016525	25	0.027	Mouse
exocytosis	GO:0006887	121	0.027	Mouse
learning or memory	GO:0007611	148	0.026
positive regulation of mapk cascade	GO:0043410	170	0.026
amine metabolic process	GO:0009308	45	0.026
neuronal action potential	GO:0019228	54	0.026
positive regulation of apoptotic process	GO:0043065	217	0.025
regulation of corticotropin releasing hormone secretion	GO:0043397	2	0.025
regulation of interleukin 1 alpha production	GO:0032650	4	0.025
cellular metal ion homeostasis	GO:0006875	151	0.025
regulation of calcium mediated signaling	GO:0050848	19	0.025
positive regulation of protein phosphorylation	GO:0001934	242	0.025
myeloid leukocyte differentiation	GO:0002573	119	0.025
somatostatin signaling pathway	GO:0038170	2	0.025
peptidyl tyrosine modification	GO:0018212	145	0.025
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.025
regulation of lymphocyte migration	GO:2000401	14	0.025	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.025
protein kinase b signaling	GO:0043491	74	0.025
intrinsic apoptotic signaling pathway	GO:0097193	132	0.025
interleukin 2 production	GO:0032623	33	0.025	Mouse
cytoplasmic transport	GO:0016482	234	0.024
positive regulation of hypersensitivity	GO:0002885	7	0.024	Mouse
regulation of bone remodeling	GO:0046850	28	0.024
monocarboxylic acid biosynthetic process	GO:0072330	61	0.024
positive regulation of kinase activity	GO:0033674	155	0.024
syncytium formation by plasma membrane fusion	GO:0000768	42	0.024
epithelial cell proliferation	GO:0050673	174	0.024	Mouse
positive regulation of organic acid transport	GO:0032892	11	0.024
inorganic ion transmembrane transport	GO:0098660	234	0.024
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.024
positive regulation of lymphocyte activation	GO:0051251	140	0.023	Mouse
posttranscriptional regulation of gene expression	GO:0010608	155	0.023
regulation of leukocyte apoptotic process	GO:2000106	56	0.023	Mouse
regulation of fatty acid transport	GO:2000191	10	0.023
homeostasis of number of cells	GO:0048872	210	0.023
protein localization to nucleus	GO:0034504	121	0.023
adenylate cyclase inhibiting g protein coupled receptor signaling pathway	GO:0007193	20	0.023
amino acid transport	GO:0006865	61	0.023
negative regulation of blood pressure	GO:0045776	22	0.023
cellular ion homeostasis	GO:0006873	165	0.023
fc receptor mediated inhibitory signaling pathway	GO:0002774	1	0.023
regulation of oligodendrocyte differentiation	GO:0048713	23	0.023	Mouse
positive regulation of calcium mediated signaling	GO:0050850	15	0.023
negative regulation of lymphocyte activation	GO:0051250	91	0.023
carbohydrate metabolic process	GO:0005975	230	0.023
plasma membrane organization	GO:0007009	90	0.023	Mouse

Xcr1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
human immunodeficiency virus infectious disease	DOID:526	0.026
acquired immunodeficiency syndrome	DOID:635	0.026
disease by infectious agent	DOID:0050117	0.026
viral infectious disease	DOID:934	0.026

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