| copper ion transport | GO:0006825 | 10 | 0.199 | |
| regulation of resting membrane potential | GO:0060075 | 3 | 0.167 | |
| modification dependent macromolecule catabolic process | GO:0043632 | 133 | 0.151 | |
| cellular protein catabolic process | GO:0044257 | 155 | 0.107 | |
| proteolysis involved in cellular protein catabolic process | GO:0051603 | 147 | 0.097 | |
| protein maturation | GO:0051604 | 176 | 0.091 | Human |
| regulation of epidermal growth factor activated receptor activity | GO:0007176 | 7 | 0.083 | |
| negative regulation of protein processing | GO:0010955 | 79 | 0.069 | |
| modification dependent protein catabolic process | GO:0019941 | 133 | 0.068 | |
| protein modification by small protein conjugation | GO:0032446 | 187 | 0.064 | |
| macromolecule catabolic process | GO:0009057 | 281 | 0.063 | |
| regulation of cellular amino acid metabolic process | GO:0006521 | 5 | 0.061 | |
| choline transport | GO:0015871 | 3 | 0.059 | |
| ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway | GO:0043162 | 3 | 0.057 | |
| lateral inhibition | GO:0046331 | 1 | 0.056 | |
| protein catabolic process | GO:0030163 | 221 | 0.054 | |
| ubiquitin dependent protein catabolic process | GO:0006511 | 129 | 0.053 | |
| negative regulation of protein metabolic process | GO:0051248 | 282 | 0.050 | |
| negative regulation of cellular protein metabolic process | GO:0032269 | 247 | 0.049 | |
| negative regulation of protein modification process | GO:0031400 | 163 | 0.044 | |
| notch receptor processing | GO:0007220 | 4 | 0.044 | |
| cellular macromolecule catabolic process | GO:0044265 | 206 | 0.043 | |
| transmembrane transport | GO:0055085 | 412 | 0.042 | |
| positive regulation of cell death | GO:0010942 | 224 | 0.042 | |
| regulation of kinase activity | GO:0043549 | 249 | 0.041 | |
| cation transport | GO:0006812 | 399 | 0.041 | |
| proteasome mediated ubiquitin dependent protein catabolic process | GO:0043161 | 88 | 0.038 | |
| ion transmembrane transport | GO:0034220 | 361 | 0.037 | |
| ribose phosphate metabolic process | GO:0019693 | 291 | 0.036 | |
| cellular amino acid metabolic process | GO:0006520 | 103 | 0.036 | |
| regulation of cellular catabolic process | GO:0031329 | 242 | 0.036 | |
| notch signaling pathway | GO:0007219 | 71 | 0.036 | Worm |
| protein processing | GO:0016485 | 163 | 0.036 | Human |
| protein modification by small protein conjugation or removal | GO:0070647 | 207 | 0.036 | |
| regulation of protein processing | GO:0070613 | 96 | 0.035 | |
| regulation of apoptotic signaling pathway | GO:2001233 | 197 | 0.035 | |
| regulation of proteolysis | GO:0030162 | 164 | 0.035 | |
| spermatogenesis | GO:0007283 | 284 | 0.035 | |
| negative regulation of molecular function | GO:0044092 | 258 | 0.034 | |
| embryonic organ morphogenesis | GO:0048562 | 276 | 0.034 | |
| apoptotic signaling pathway | GO:0097190 | 306 | 0.033 | |
| negative regulation of cellular amino acid metabolic process | GO:0045763 | 0 | 0.033 | |
| mitochondrion organization | GO:0007005 | 134 | 0.032 | |
| extrinsic apoptotic signaling pathway via death domain receptors | GO:0008625 | 34 | 0.031 | |
| protein ubiquitination | GO:0016567 | 171 | 0.031 | |
| regulation of protein maturation | GO:1903317 | 96 | 0.031 | |
| proteasomal protein catabolic process | GO:0010498 | 98 | 0.030 | |
| regulation of neuron differentiation | GO:0045664 | 281 | 0.029 | |
| microtubule based process | GO:0007017 | 236 | 0.029 | |
| negative regulation of epidermal growth factor activated receptor activity | GO:0007175 | 3 | 0.028 | |
| beta amyloid metabolic process | GO:0050435 | 14 | 0.028 | |
| cation transmembrane transport | GO:0098655 | 266 | 0.028 | |
| cellular ketone metabolic process | GO:0042180 | 84 | 0.028 | |
| cellular protein complex assembly | GO:0043623 | 116 | 0.027 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 66 | 0.027 | |
| negative regulation of proteolysis | GO:0045861 | 74 | 0.027 | |
| negative regulation of protein tyrosine kinase activity | GO:0061099 | 3 | 0.027 | |
| transition metal ion transport | GO:0000041 | 38 | 0.026 | |
| negative regulation of protein maturation | GO:1903318 | 79 | 0.026 | |
| regulation of cellular protein catabolic process | GO:1903362 | 61 | 0.026 | |
| inorganic ion transmembrane transport | GO:0098660 | 234 | 0.025 | |
| determination of left right symmetry | GO:0007368 | 80 | 0.025 | |
| organelle fission | GO:0048285 | 170 | 0.025 | |
| positive regulation of apoptotic signaling pathway | GO:2001235 | 95 | 0.025 | |
| endomembrane system organization | GO:0010256 | 147 | 0.024 | |
| cellular divalent inorganic cation homeostasis | GO:0072503 | 127 | 0.024 | |
| positive regulation of proteolysis | GO:0045862 | 85 | 0.024 | |
| cellular amine metabolic process | GO:0044106 | 44 | 0.024 | |
| regulation of hydrolase activity | GO:0051336 | 246 | 0.023 | |
| negative regulation of cellular catabolic process | GO:0031330 | 47 | 0.023 | |
| regulation of cellular component biogenesis | GO:0044087 | 181 | 0.022 | |
| transmembrane receptor protein tyrosine kinase signaling pathway | GO:0007169 | 247 | 0.022 | |
| cytoplasmic transport | GO:0016482 | 234 | 0.022 | |
| divalent inorganic cation transport | GO:0072511 | 178 | 0.022 | |
| growth involved in heart morphogenesis | GO:0003241 | 4 | 0.021 | |
| regulation of cellular amine metabolic process | GO:0033238 | 20 | 0.021 | |
| regulation of membrane potential | GO:0042391 | 192 | 0.021 | |
| response to extracellular stimulus | GO:0009991 | 127 | 0.021 | |
| regulation of transferase activity | GO:0051338 | 263 | 0.021 | |
| negative regulation of cell development | GO:0010721 | 169 | 0.021 | |
| regulation of neurotransmitter levels | GO:0001505 | 87 | 0.020 | |
| endoplasmic reticulum calcium ion homeostasis | GO:0032469 | 11 | 0.020 | |
| epithelial cell proliferation | GO:0050673 | 174 | 0.020 | |
| ossification | GO:0001503 | 216 | 0.020 | |
| purine ribonucleotide metabolic process | GO:0009150 | 290 | 0.019 | |
| membrane lipid biosynthetic process | GO:0046467 | 32 | 0.019 | |
| inorganic cation transmembrane transport | GO:0098662 | 207 | 0.019 | |
| neuron death | GO:0070997 | 154 | 0.019 | Zebrafish |
| carbohydrate derivative catabolic process | GO:1901136 | 231 | 0.019 | |
| negative regulation of protein phosphorylation | GO:0001933 | 126 | 0.019 | |
| cation homeostasis | GO:0055080 | 212 | 0.019 | |
| neurotransmitter transport | GO:0006836 | 76 | 0.019 | |
| nuclear division | GO:0000280 | 158 | 0.019 | |
| release of cytochrome c from mitochondria | GO:0001836 | 23 | 0.019 | |
| regulation of cell projection organization | GO:0031344 | 206 | 0.019 | |
| interspecies interaction between organisms | GO:0044419 | 83 | 0.019 | |
| nucleoside triphosphate catabolic process | GO:0009143 | 205 | 0.019 | |
| extracellular structure organization | GO:0043062 | 148 | 0.019 | |
| regulation of protein modification by small protein conjugation or removal | GO:1903320 | 57 | 0.019 | |
| nitrogen compound transport | GO:0071705 | 271 | 0.019 | |
| t cell activation | GO:0042110 | 289 | 0.019 | |
| negative regulation of cellular protein catabolic process | GO:1903363 | 22 | 0.018 | |
| regulation of protein catabolic process | GO:0042176 | 108 | 0.018 | |
| ras protein signal transduction | GO:0007265 | 77 | 0.018 | |
| amine metabolic process | GO:0009308 | 45 | 0.018 | |
| microtubule based movement | GO:0007018 | 84 | 0.018 | |
| protein localization to membrane | GO:0072657 | 108 | 0.018 | |
| regionalization | GO:0003002 | 337 | 0.018 | |
| regulation of peptidase activity | GO:0052547 | 96 | 0.018 | |
| immune effector process | GO:0002252 | 321 | 0.018 | |
| male gamete generation | GO:0048232 | 285 | 0.018 | |
| negative regulation of kinase activity | GO:0033673 | 81 | 0.018 | |
| positive regulation of transferase activity | GO:0051347 | 167 | 0.018 | |
| regulation of secretion | GO:0051046 | 274 | 0.018 | |
| hematopoietic progenitor cell differentiation | GO:0002244 | 143 | 0.018 | |
| digestive tract development | GO:0048565 | 190 | 0.018 | Worm |
| negative regulation of neuron differentiation | GO:0045665 | 101 | 0.018 | |
| autophagic vacuole fusion | GO:0000046 | 1 | 0.017 | |
| organelle membrane fusion | GO:0090174 | 1 | 0.017 | |
| regulation of proteolysis involved in cellular protein catabolic process | GO:1903050 | 56 | 0.017 | |
| cellular chemical homeostasis | GO:0055082 | 215 | 0.017 | |
| negative regulation of protein modification by small protein conjugation or removal | GO:1903321 | 20 | 0.017 | |
| organic hydroxy compound transport | GO:0015850 | 93 | 0.017 | |
| peptidyl amino acid modification | GO:0018193 | 336 | 0.017 | |
| positive regulation of protein phosphorylation | GO:0001934 | 242 | 0.016 | |
| negative regulation of ligase activity | GO:0051352 | 3 | 0.016 | |
| extrinsic apoptotic signaling pathway | GO:0097191 | 126 | 0.016 | |
| regulation of cell migration | GO:0030334 | 219 | 0.016 | |
| negative regulation of ubiquitin protein transferase activity | GO:0051444 | 3 | 0.016 | |
| regulation of intracellular protein transport | GO:0033157 | 82 | 0.016 | |
| purine containing compound metabolic process | GO:0072521 | 311 | 0.016 | |
| cellular response to extracellular stimulus | GO:0031668 | 81 | 0.016 | |
| mapk cascade | GO:0000165 | 281 | 0.016 | |
| regulation of establishment of protein localization | GO:0070201 | 181 | 0.016 | |
| ribonucleoside metabolic process | GO:0009119 | 245 | 0.016 | |
| negative regulation of phosphorylation | GO:0042326 | 166 | 0.016 | |
| vesicle organization | GO:0016050 | 60 | 0.016 | |
| autophagy | GO:0006914 | 45 | 0.016 | |
| carbohydrate homeostasis | GO:0033500 | 128 | 0.016 | |
| acidic amino acid transport | GO:0015800 | 16 | 0.016 | |
| regulation of organelle organization | GO:0033043 | 289 | 0.015 | |
| positive regulation of transcription from rna polymerase ii promoter in response to stress | GO:0036003 | 3 | 0.015 | |
| cellular homeostasis | GO:0019725 | 240 | 0.015 | |
| regulation of cytoplasmic transport | GO:1903649 | 112 | 0.015 | |
| intracellular protein transport | GO:0006886 | 204 | 0.015 | |
| divalent metal ion transport | GO:0070838 | 172 | 0.015 | |
| negative regulation of phosphate metabolic process | GO:0045936 | 184 | 0.015 | |
| membrane organization | GO:0061024 | 245 | 0.015 | |
| purine nucleoside metabolic process | GO:0042278 | 241 | 0.015 | |
| synaptic transmission | GO:0007268 | 329 | 0.015 | |
| positive regulation of mapk cascade | GO:0043410 | 170 | 0.015 | |
| regulation of ion transport | GO:0043269 | 215 | 0.015 | |
| regulation of protein localization | GO:0032880 | 231 | 0.015 | |
| myotube differentiation | GO:0014902 | 105 | 0.015 | |
| regulation of protein kinase activity | GO:0045859 | 232 | 0.015 | |
| nucleotide metabolic process | GO:0009117 | 332 | 0.015 | |
| positive regulation of interleukin 8 production | GO:0032757 | 2 | 0.015 | |
| heart morphogenesis | GO:0003007 | 178 | 0.014 | |
| water soluble vitamin biosynthetic process | GO:0042364 | 3 | 0.014 | |
| leukocyte differentiation | GO:0002521 | 342 | 0.014 | |
| respiratory tube development | GO:0030323 | 167 | 0.014 | |
| regulation of cell motility | GO:2000145 | 236 | 0.014 | |
| positive regulation of protein kinase activity | GO:0045860 | 144 | 0.014 | |
| positive regulation of protein modification process | GO:0031401 | 299 | 0.014 | |
| positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | GO:1902043 | 13 | 0.014 | |
| regulation of protein serine threonine kinase activity | GO:0071900 | 157 | 0.014 | |
| autophagic vacuole assembly | GO:0000045 | 13 | 0.014 | |
| purine ribonucleoside triphosphate catabolic process | GO:0009207 | 199 | 0.014 | |
| negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | GO:1902042 | 11 | 0.014 | |
| cellular response to dna damage stimulus | GO:0006974 | 207 | 0.014 | |
| regulation of mapk cascade | GO:0043408 | 248 | 0.014 | |
| regulation of vesicle mediated transport | GO:0060627 | 139 | 0.014 | |
| exocytosis | GO:0006887 | 121 | 0.014 | |
| organelle localization | GO:0051640 | 179 | 0.014 | |
| ribonucleoside triphosphate catabolic process | GO:0009203 | 199 | 0.014 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 184 | 0.014 | |
| negative regulation of cellular component organization | GO:0051129 | 194 | 0.014 | |
| positive regulation of programmed cell death | GO:0043068 | 218 | 0.014 | |
| positive regulation of proteolysis involved in cellular protein catabolic process | GO:1903052 | 31 | 0.013 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 5 | 0.013 | |
| somitogenesis | GO:0001756 | 69 | 0.013 | |
| embryonic heart tube morphogenesis | GO:0003143 | 51 | 0.013 | |
| developmental maturation | GO:0021700 | 193 | 0.013 | |
| regulation of map kinase activity | GO:0043405 | 120 | 0.013 | |
| viral budding | GO:0046755 | 1 | 0.013 | |
| negative regulation of nervous system development | GO:0051961 | 156 | 0.013 | |
| regulation of proteasomal protein catabolic process | GO:0061136 | 46 | 0.013 | |
| purine nucleotide catabolic process | GO:0006195 | 211 | 0.013 | |
| negative regulation of apoptotic signaling pathway | GO:2001234 | 104 | 0.013 | |
| cellular ion homeostasis | GO:0006873 | 165 | 0.013 | |
| single organism cell adhesion | GO:0098602 | 156 | 0.013 | |
| calcium ion homeostasis | GO:0055074 | 127 | 0.013 | |
| symbiosis encompassing mutualism through parasitism | GO:0044403 | 83 | 0.013 | |
| regulation of receptor recycling | GO:0001919 | 8 | 0.013 | |
| mitotic cell cycle | GO:0000278 | 195 | 0.013 | |
| nucleoside phosphate metabolic process | GO:0006753 | 338 | 0.013 | |
| posttranscriptional regulation of gene expression | GO:0010608 | 155 | 0.013 | |
| purine nucleoside catabolic process | GO:0006152 | 205 | 0.013 | |
| ameboidal type cell migration | GO:0001667 | 128 | 0.013 | |
| meiotic nuclear division | GO:0007126 | 115 | 0.013 | |
| somite development | GO:0061053 | 81 | 0.013 | |
| regulation of endopeptidase activity | GO:0052548 | 89 | 0.013 | |
| nucleobase containing small molecule metabolic process | GO:0055086 | 352 | 0.012 | |
| organic cyclic compound catabolic process | GO:1901361 | 295 | 0.012 | |
| meiotic cell cycle | GO:0051321 | 122 | 0.012 | |
| regulation of lymphocyte activation | GO:0051249 | 240 | 0.012 | |
| purine nucleoside triphosphate metabolic process | GO:0009144 | 226 | 0.012 | |
| heterocycle catabolic process | GO:0046700 | 280 | 0.012 | |
| locomotory behavior | GO:0007626 | 195 | 0.012 | |
| filopodium assembly | GO:0046847 | 19 | 0.012 | |
| activation of mapkk activity | GO:0000186 | 15 | 0.012 | |
| blood circulation | GO:0008015 | 195 | 0.012 | |
| regulation of epithelial cell proliferation | GO:0050678 | 141 | 0.012 | |
| establishment of organelle localization | GO:0051656 | 122 | 0.012 | |
| establishment of vesicle localization | GO:0051650 | 81 | 0.012 | |
| regulation of secretion by cell | GO:1903530 | 249 | 0.012 | |
| embryonic limb morphogenesis | GO:0030326 | 126 | 0.012 | |
| smoothened signaling pathway | GO:0007224 | 105 | 0.012 | |
| inflammatory response | GO:0006954 | 244 | 0.012 | |
| negative regulation of proteolysis involved in cellular protein catabolic process | GO:1903051 | 22 | 0.012 | |
| negative regulation of transferase activity | GO:0051348 | 85 | 0.012 | |
| cell growth | GO:0016049 | 130 | 0.012 | |
| purine ribonucleotide catabolic process | GO:0009154 | 208 | 0.011 | |
| actin cytoskeleton organization | GO:0030036 | 220 | 0.011 | |
| interleukin 8 production | GO:0032637 | 4 | 0.011 | |
| positive regulation of apoptotic process | GO:0043065 | 217 | 0.011 | |
| regulation of transmembrane transport | GO:0034762 | 128 | 0.011 | |
| nucleotide catabolic process | GO:0009166 | 217 | 0.011 | |
| negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process | GO:2000059 | 6 | 0.011 | |
| regulation of neuron projection development | GO:0010975 | 169 | 0.011 | |
| negative regulation of erbb signaling pathway | GO:1901185 | 7 | 0.011 | |
| amino acid transport | GO:0006865 | 61 | 0.011 | |
| skeletal system development | GO:0001501 | 356 | 0.011 | |
| regulation of cell activation | GO:0050865 | 289 | 0.011 | |
| lipoprotein metabolic process | GO:0042157 | 43 | 0.011 | |
| glucose homeostasis | GO:0042593 | 128 | 0.011 | |
| striated muscle myosin thick filament assembly | GO:0071688 | 1 | 0.011 | |
| respiratory system development | GO:0060541 | 190 | 0.011 | |
| anatomical structure homeostasis | GO:0060249 | 145 | 0.011 | |
| response to oxidative stress | GO:0006979 | 123 | 0.011 | |
| negative regulation of cell cycle | GO:0045786 | 123 | 0.011 | |
| learning or memory | GO:0007611 | 148 | 0.011 | |
| negative regulation of protein catabolic process | GO:0042177 | 36 | 0.011 | |
| secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development | GO:0060528 | 4 | 0.011 | |
| muscle contraction | GO:0006936 | 101 | 0.011 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 3 | 0.011 | |
| regulation of protein transport | GO:0051223 | 163 | 0.011 | |
| response to nutrient levels | GO:0031667 | 109 | 0.010 | |
| muscle tissue development | GO:0060537 | 308 | 0.010 | |
| metal ion homeostasis | GO:0055065 | 189 | 0.010 | |
| regulation of protein binding | GO:0043393 | 60 | 0.010 | |
| limb development | GO:0060173 | 166 | 0.010 | |
| cellular response to cytokine stimulus | GO:0071345 | 189 | 0.010 | |
| circulatory system process | GO:0003013 | 197 | 0.010 | |
| cellular nitrogen compound catabolic process | GO:0044270 | 280 | 0.010 | |
| organonitrogen compound biosynthetic process | GO:1901566 | 192 | 0.010 | |
| cellular response to lipid | GO:0071396 | 145 | 0.010 | |
| positive regulation of kinase activity | GO:0033674 | 155 | 0.010 | |
| vesicle localization | GO:0051648 | 86 | 0.010 | |
| virion assembly | GO:0019068 | 1 | 0.010 | |
| digestive system development | GO:0055123 | 200 | 0.010 | Worm |
| limb morphogenesis | GO:0035108 | 149 | 0.010 | |
| response to starvation | GO:0042594 | 65 | 0.010 | |
| neurotransmitter secretion | GO:0007269 | 62 | 0.010 | |
| epithelial tube morphogenesis | GO:0060562 | 303 | 0.010 | |
