IMP: Integrative Multi-species Prediction

Mus musculus

8 known processes

Siva1

SIVA1, apoptosis-inducing factor

(Aliases: CD27bp,Siva)

Entrez: 30954
Ensembl: ENSMUSG00000064326
UniProtKB: O54926

Process Predictions
Disease Predictions

Siva1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna repair	GO:0006281	107	0.630
cellular response to dna damage stimulus	GO:0006974	207	0.381
dna metabolic process	GO:0006259	303	0.338
nucleobase containing small molecule metabolic process	GO:0055086	352	0.095
protein ubiquitination	GO:0016567	171	0.073
protein modification by small protein conjugation	GO:0032446	187	0.061
dna replication	GO:0006260	52	0.059
amine metabolic process	GO:0009308	45	0.052
regulation of cellular amine metabolic process	GO:0033238	20	0.052
regulation of cellular amino acid metabolic process	GO:0006521	5	0.048
cellular ketone metabolic process	GO:0042180	84	0.048
cellular amino acid metabolic process	GO:0006520	103	0.046
positive regulation of protein modification process	GO:0031401	299	0.043
regulation of mitotic cell cycle	GO:0007346	126	0.042
regulation of cellular ketone metabolic process	GO:0010565	66	0.041
cellular amine metabolic process	GO:0044106	44	0.040
organic cyclic compound catabolic process	GO:1901361	295	0.040
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	43	0.040
macromolecule catabolic process	GO:0009057	281	0.039
nucleotide excision repair	GO:0006289	13	0.039
heterocycle catabolic process	GO:0046700	280	0.036
organelle assembly	GO:0070925	177	0.034
transcription elongation from rna polymerase ii promoter	GO:0006368	9	0.034
regulation of hormone levels	GO:0010817	211	0.034
nitrogen compound transport	GO:0071705	271	0.033
cellular protein catabolic process	GO:0044257	155	0.033
germ cell development	GO:0007281	185	0.032
positive regulation of cellular amine metabolic process	GO:0033240	5	0.032
rna processing	GO:0006396	105	0.031
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.030
cellular macromolecule catabolic process	GO:0044265	206	0.029
nucleoside phosphate metabolic process	GO:0006753	338	0.029
dna dependent dna replication	GO:0006261	24	0.029
purine nucleoside metabolic process	GO:0042278	241	0.029
homeostasis of number of cells	GO:0048872	210	0.028	Human
meiosis i	GO:0007127	60	0.028
organonitrogen compound biosynthetic process	GO:1901566	192	0.027
purine containing compound metabolic process	GO:0072521	311	0.027
base excision repair	GO:0006284	9	0.027
aromatic compound catabolic process	GO:0019439	286	0.025
mrna metabolic process	GO:0016071	84	0.024
regulation of embryonic development	GO:0045995	71	0.023
response to oxidative stress	GO:0006979	123	0.023
striated muscle tissue development	GO:0014706	293	0.022
ribonucleotide metabolic process	GO:0009259	291	0.021
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.020
negative regulation of molecular function	GO:0044092	258	0.020	Human
negative regulation of cellular protein metabolic process	GO:0032269	247	0.020
negative regulation of protein metabolic process	GO:0051248	282	0.018
proprioception	GO:0019230	4	0.018
purine nucleotide metabolic process	GO:0006163	302	0.018
nucleocytoplasmic transport	GO:0006913	139	0.018
posttranscriptional regulation of gene expression	GO:0010608	155	0.018
purine ribonucleoside metabolic process	GO:0046128	241	0.018
nucleotide metabolic process	GO:0009117	332	0.018
regulation of hydrolase activity	GO:0051336	246	0.017
reactive oxygen species metabolic process	GO:0072593	84	0.017
organelle fission	GO:0048285	170	0.017
dna replication independent nucleosome assembly	GO:0006336	1	0.017
cellular homeostasis	GO:0019725	240	0.017
dna recombination	GO:0006310	92	0.016
chemotaxis	GO:0006935	247	0.016
cellular nitrogen compound catabolic process	GO:0044270	280	0.016
regulation of cell cycle	GO:0051726	281	0.016
regulation of mapk cascade	GO:0043408	248	0.016
cytoplasmic transport	GO:0016482	234	0.015
muscle cell differentiation	GO:0042692	261	0.015
cell cycle checkpoint	GO:0000075	47	0.015
nuclear transport	GO:0051169	139	0.015
protein oligomerization	GO:0051259	67	0.015
nucleoside phosphate catabolic process	GO:1901292	222	0.015
nucleoside metabolic process	GO:0009116	246	0.014
establishment of rna localization	GO:0051236	18	0.014
mrna processing	GO:0006397	63	0.014
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.014
regulation of cellular catabolic process	GO:0031329	242	0.014
mitochondrion organization	GO:0007005	134	0.014	Human
mitotic cell cycle process	GO:1903047	159	0.014
negative regulation of cell proliferation	GO:0008285	296	0.014
male gamete generation	GO:0048232	285	0.014
positive regulation of defense response	GO:0031349	124	0.014
transcription coupled nucleotide excision repair	GO:0006283	2	0.014
response to organic cyclic compound	GO:0014070	198	0.014
regulation of homeostatic process	GO:0032844	182	0.014
telomere maintenance via telomerase	GO:0007004	1	0.014
immune effector process	GO:0002252	321	0.014
ras protein signal transduction	GO:0007265	77	0.013
peptidyl amino acid modification	GO:0018193	336	0.013
regulation of cell cycle phase transition	GO:1901987	77	0.013
lateral inhibition	GO:0046331	1	0.013
protein modification by small protein conjugation or removal	GO:0070647	207	0.013
protein polyubiquitination	GO:0000209	33	0.013
metal ion homeostasis	GO:0055065	189	0.013
rna splicing	GO:0008380	54	0.013
gland development	GO:0048732	330	0.012
regulation of cell cycle process	GO:0010564	160	0.012
negative regulation of dna replication	GO:0008156	4	0.012
sensory perception	GO:0007600	245	0.012
cellular component assembly involved in morphogenesis	GO:0010927	139	0.012
cation transport	GO:0006812	399	0.012
cellular metal ion homeostasis	GO:0006875	151	0.012
negative regulation of phosphate metabolic process	GO:0045936	184	0.012
small gtpase mediated signal transduction	GO:0007264	97	0.012
multi organism behavior	GO:0051705	62	0.012
multicellular organism growth	GO:0035264	161	0.012
cellular response to growth factor stimulus	GO:0071363	197	0.012
mitotic cell cycle	GO:0000278	195	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.011
epithelial cell proliferation	GO:0050673	174	0.011
endocytosis	GO:0006897	168	0.011
cell chemotaxis	GO:0060326	81	0.011
anatomical structure homeostasis	GO:0060249	145	0.011
response to iron ion	GO:0010039	4	0.011
dna dependent dna replication maintenance of fidelity	GO:0045005	3	0.011
regulation of lymphocyte activation	GO:0051249	240	0.011
negative regulation of cell cycle process	GO:0010948	69	0.011
dna templated transcription initiation	GO:0006352	13	0.011
dna templated transcription termination	GO:0006353	4	0.011
epidermal growth factor receptor signaling pathway	GO:0007173	28	0.011
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.011
transmembrane transport	GO:0055085	412	0.011
amide transport	GO:0042886	138	0.010
translation	GO:0006412	93	0.010
organophosphate catabolic process	GO:0046434	232	0.010
regulation of cellular response to stress	GO:0080135	159	0.010
positive regulation of protein phosphorylation	GO:0001934	242	0.010
rna catabolic process	GO:0006401	29	0.010
organonitrogen compound catabolic process	GO:1901565	264	0.010
protein catabolic process	GO:0030163	221	0.010

Siva1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.041
disease of anatomical entity	DOID:7	0.027
nervous system disease	DOID:863	0.027
inherited metabolic disorder	DOID:655	0.017
central nervous system disease	DOID:331	0.011

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