IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Shprh

SNF2 histone linker PHD RING helicase

(Aliases: E130018M05,2610103K11Rik,AA450458,BC006883,D230017O13Rik,AU024614)

Entrez: 268281
Ensembl: ENSMUSG00000090112
UniProtKB: Q7TPQ3

Process Predictions
Disease Predictions

Shprh biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
protein modification by small protein conjugation	GO:0032446	187	0.182
histone modification	GO:0016570	159	0.165
chromatin modification	GO:0016568	187	0.151
chromatin organization	GO:0006325	206	0.124
covalent chromatin modification	GO:0016569	163	0.105
ras protein signal transduction	GO:0007265	77	0.095
protein ubiquitination	GO:0016567	171	0.078
protein modification by small protein conjugation or removal	GO:0070647	207	0.066
small gtpase mediated signal transduction	GO:0007264	97	0.062
cellular homeostasis	GO:0019725	240	0.059
cellular nitrogen compound catabolic process	GO:0044270	280	0.056
peptidyl amino acid modification	GO:0018193	336	0.049
forebrain development	GO:0030900	302	0.043
regulation of cellular amino acid metabolic process	GO:0006521	5	0.042
stem cell differentiation	GO:0048863	268	0.039
bmp signaling pathway	GO:0030509	93	0.037
heterocycle catabolic process	GO:0046700	280	0.036
cellular macromolecule catabolic process	GO:0044265	206	0.036
regulation of ras protein signal transduction	GO:0046578	114	0.035
cytoplasmic transport	GO:0016482	234	0.035
organic cyclic compound catabolic process	GO:1901361	295	0.034
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.034
regulation of cellular amine metabolic process	GO:0033238	20	0.033
negative regulation of intracellular signal transduction	GO:1902532	167	0.033
cell division	GO:0051301	120	0.033
regulation of chromosome organization	GO:0033044	83	0.033
stem cell maintenance	GO:0019827	130	0.033
regulation of cellular ketone metabolic process	GO:0010565	66	0.031
stem cell development	GO:0048864	219	0.031
sensory organ morphogenesis	GO:0090596	242	0.031
cellular amino acid metabolic process	GO:0006520	103	0.031
regulation of mitotic cell cycle	GO:0007346	126	0.030
cognition	GO:0050890	149	0.030
cell type specific apoptotic process	GO:0097285	268	0.030
macromolecule catabolic process	GO:0009057	281	0.030
heart morphogenesis	GO:0003007	178	0.030
dna metabolic process	GO:0006259	303	0.030
cellular amine metabolic process	GO:0044106	44	0.029
negative regulation of cell cycle	GO:0045786	123	0.028
positive regulation of cellular catabolic process	GO:0031331	148	0.028
positive regulation of cellular amine metabolic process	GO:0033240	5	0.028
nucleoside phosphate metabolic process	GO:0006753	338	0.027
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.027
muscle system process	GO:0003012	141	0.027
axonogenesis	GO:0007409	274	0.027
cation transport	GO:0006812	399	0.027
cellular response to dna damage stimulus	GO:0006974	207	0.026
blood circulation	GO:0008015	195	0.026
glycosyl compound metabolic process	GO:1901657	246	0.026
modification dependent macromolecule catabolic process	GO:0043632	133	0.025
macromolecule methylation	GO:0043414	120	0.025
response to organonitrogen compound	GO:0010243	246	0.025
amine metabolic process	GO:0009308	45	0.025
methylation	GO:0032259	134	0.025
dna modification	GO:0006304	50	0.025
mapk cascade	GO:0000165	281	0.025
camera type eye development	GO:0043010	266	0.025
sensory perception	GO:0007600	245	0.025
nucleobase containing small molecule metabolic process	GO:0055086	352	0.025
purine containing compound metabolic process	GO:0072521	311	0.025
circulatory system process	GO:0003013	197	0.024
regulation of proteolysis	GO:0030162	164	0.024
axon guidance	GO:0007411	141	0.024
cellular ketone metabolic process	GO:0042180	84	0.024
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.023
anatomical structure homeostasis	GO:0060249	145	0.023
nucleotide metabolic process	GO:0009117	332	0.023
rho protein signal transduction	GO:0007266	32	0.023
protein catabolic process	GO:0030163	221	0.023
positive regulation of protein modification process	GO:0031401	299	0.023
ribonucleoside catabolic process	GO:0042454	206	0.023
regulation of cell cycle phase transition	GO:1901987	77	0.023
multicellular organism growth	GO:0035264	161	0.023
membrane organization	GO:0061024	245	0.022
cellular response to organonitrogen compound	GO:0071417	145	0.022
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.022
regulation of cell cycle	GO:0051726	281	0.022
purine nucleotide metabolic process	GO:0006163	302	0.022
protein polyubiquitination	GO:0000209	33	0.022
blood vessel morphogenesis	GO:0048514	285	0.021
telomere maintenance	GO:0000723	19	0.021
carbohydrate derivative catabolic process	GO:1901136	231	0.021
nucleoside metabolic process	GO:0009116	246	0.021
nucleoside catabolic process	GO:0009164	206	0.021
mitochondrion organization	GO:0007005	134	0.021
purine nucleotide catabolic process	GO:0006195	211	0.020
cellular response to lipid	GO:0071396	145	0.020
aromatic compound catabolic process	GO:0019439	286	0.020
regulation of cellular response to stress	GO:0080135	159	0.020
response to light stimulus	GO:0009416	135	0.020
negative regulation of cell proliferation	GO:0008285	296	0.020
purine ribonucleotide catabolic process	GO:0009154	208	0.020
learning or memory	GO:0007611	148	0.020
ossification	GO:0001503	216	0.020
ribonucleoside metabolic process	GO:0009119	245	0.020
purine nucleoside metabolic process	GO:0042278	241	0.019
response to insulin	GO:0032868	100	0.019
response to growth factor	GO:0070848	198	0.019
ubiquitin dependent protein catabolic process	GO:0006511	129	0.019
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.019
protein localization to organelle	GO:0033365	185	0.019
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.019
regulation of nuclear division	GO:0051783	56	0.019
cation homeostasis	GO:0055080	212	0.019
regulation of organelle organization	GO:0033043	289	0.019
nuclear transport	GO:0051169	139	0.019
nuclear division	GO:0000280	158	0.019
regulation of cellular catabolic process	GO:0031329	242	0.019
cellular protein catabolic process	GO:0044257	155	0.019
nucleocytoplasmic transport	GO:0006913	139	0.018
ribonucleotide metabolic process	GO:0009259	291	0.018
respiratory system development	GO:0060541	190	0.018
response to radiation	GO:0009314	165	0.018
mitotic cell cycle process	GO:1903047	159	0.018
intracellular protein transport	GO:0006886	204	0.018
telencephalon development	GO:0021537	186	0.018
ear development	GO:0043583	200	0.018
protein localization to nucleus	GO:0034504	121	0.018
blastocyst development	GO:0001824	80	0.018
negative regulation of cellular protein metabolic process	GO:0032269	247	0.018
cytokine production	GO:0001816	319	0.018
mitotic cell cycle	GO:0000278	195	0.017
cellular chemical homeostasis	GO:0055082	215	0.017
purine ribonucleotide metabolic process	GO:0009150	290	0.017
chemotaxis	GO:0006935	247	0.017
regulation of cell activation	GO:0050865	289	0.017
ribose phosphate metabolic process	GO:0019693	291	0.017
cell aging	GO:0007569	35	0.017
negative regulation of protein modification process	GO:0031400	163	0.017
divalent inorganic cation transport	GO:0072511	178	0.017
negative regulation of phosphate metabolic process	GO:0045936	184	0.016
regulation of neuron differentiation	GO:0045664	281	0.016
regulation of mapk cascade	GO:0043408	248	0.016
muscle contraction	GO:0006936	101	0.016
purine ribonucleoside catabolic process	GO:0046130	205	0.016
cellular ion homeostasis	GO:0006873	165	0.016
skeletal system development	GO:0001501	356	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.016
cellular response to hormone stimulus	GO:0032870	150	0.016
telomere maintenance in response to dna damage	GO:0043247	4	0.016
negative regulation of protein metabolic process	GO:0051248	282	0.016
protein acylation	GO:0043543	64	0.016
glucose homeostasis	GO:0042593	128	0.016
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.016
divalent inorganic cation homeostasis	GO:0072507	138	0.016
artery development	GO:0060840	53	0.016
cellular magnesium ion homeostasis	GO:0010961	3	0.015
transmembrane transport	GO:0055085	412	0.015
stem cell proliferation	GO:0072089	117	0.015
positive regulation of organelle organization	GO:0010638	128	0.015
negative regulation of phosphorylation	GO:0042326	166	0.015
regulation of protein catabolic process	GO:0042176	108	0.015
purine nucleoside catabolic process	GO:0006152	205	0.015
dna recombination	GO:0006310	92	0.015
regulation of epithelial cell proliferation	GO:0050678	141	0.015
nucleoside triphosphate metabolic process	GO:0009141	230	0.015
organonitrogen compound catabolic process	GO:1901565	264	0.015
organophosphate catabolic process	GO:0046434	232	0.014
oxidation reduction process	GO:0055114	342	0.014
response to extracellular stimulus	GO:0009991	127	0.014
central nervous system neuron differentiation	GO:0021953	162	0.014
cation transmembrane transport	GO:0098655	266	0.014
negative regulation of cellular component organization	GO:0051129	194	0.014
cellular response to peptide	GO:1901653	92	0.014
maintenance of location	GO:0051235	89	0.014
regulation of system process	GO:0044057	200	0.014
apoptotic signaling pathway	GO:0097190	306	0.014
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.014
neuron projection guidance	GO:0097485	141	0.014
organelle localization	GO:0051640	179	0.014
regulation of membrane potential	GO:0042391	192	0.014
cellular response to peptide hormone stimulus	GO:0071375	92	0.014
protein maturation	GO:0051604	176	0.014
regulation of apoptotic signaling pathway	GO:2001233	197	0.014
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.014
organelle fission	GO:0048285	170	0.014
negative regulation of cell development	GO:0010721	169	0.014
response to lipopolysaccharide	GO:0032496	128	0.013
purine ribonucleoside metabolic process	GO:0046128	241	0.013
leukocyte differentiation	GO:0002521	342	0.013
regulation of intracellular transport	GO:0032386	159	0.013
sodium ion transport	GO:0006814	73	0.013
histone methylation	GO:0016571	71	0.013
nucleoside triphosphate catabolic process	GO:0009143	205	0.013
protection from non homologous end joining at telomere	GO:0031848	4	0.013
positive regulation of proteolysis	GO:0045862	85	0.013
mitotic nuclear division	GO:0007067	48	0.013
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.013
neural precursor cell proliferation	GO:0061351	121	0.013
nucleoside phosphate catabolic process	GO:1901292	222	0.013
inorganic cation transmembrane transport	GO:0098662	207	0.013
positive regulation of chromosome organization	GO:2001252	33	0.013
gland development	GO:0048732	330	0.012
regulation of protein localization	GO:0032880	231	0.012
modification dependent protein catabolic process	GO:0019941	133	0.012
purine containing compound catabolic process	GO:0072523	213	0.012
metal ion homeostasis	GO:0055065	189	0.012
glycoprotein metabolic process	GO:0009100	116	0.012
regulation of cell division	GO:0051302	76	0.012
ribonucleotide catabolic process	GO:0009261	208	0.012
negative regulation of cell cycle process	GO:0010948	69	0.012
epithelial cell proliferation	GO:0050673	174	0.012
limb morphogenesis	GO:0035108	149	0.012
response to peptide hormone	GO:0043434	127	0.012
microtubule based process	GO:0007017	236	0.012
epithelial tube morphogenesis	GO:0060562	303	0.012
muscle tissue development	GO:0060537	308	0.012
regulation of protein modification by small protein conjugation or removal	GO:1903320	57	0.012
protein targeting	GO:0006605	143	0.012
posttranscriptional regulation of gene expression	GO:0010608	155	0.012
retina development in camera type eye	GO:0060041	119	0.012
translesion synthesis	GO:0019985	1	0.012
organonitrogen compound biosynthetic process	GO:1901566	192	0.012
carbohydrate derivative biosynthetic process	GO:1901137	183	0.012
atp metabolic process	GO:0046034	75	0.011
regulation of cytoplasmic transport	GO:1903649	112	0.011
apoptotic mitochondrial changes	GO:0008637	48	0.011
tube formation	GO:0035148	140	0.011
negative regulation of phosphorus metabolic process	GO:0010563	184	0.011
regulation of rho protein signal transduction	GO:0035023	71	0.011
t cell activation	GO:0042110	289	0.011
immune effector process	GO:0002252	321	0.011
appendage development	GO:0048736	166	0.011
defecation	GO:0030421	1	0.011
myeloid cell differentiation	GO:0030099	233	0.011
negative regulation of mitotic cell cycle	GO:0045930	58	0.011
mitotic cell cycle checkpoint	GO:0007093	31	0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.011
negative regulation of molecular function	GO:0044092	258	0.011
memory	GO:0007613	58	0.011
rna processing	GO:0006396	105	0.011
epithelial cell development	GO:0002064	159	0.011
endomembrane system organization	GO:0010256	147	0.011
negative regulation of immune effector process	GO:0002698	55	0.011
positive regulation of growth	GO:0045927	104	0.011
sensory perception of mechanical stimulus	GO:0050954	107	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.011
eye photoreceptor cell differentiation	GO:0001754	41	0.010
negative regulation of mesenchymal cell proliferation	GO:0072201	3	0.010
nucleoside monophosphate metabolic process	GO:0009123	85	0.010
nucleotide catabolic process	GO:0009166	217	0.010
positive regulation of cell development	GO:0010720	237	0.010
regulation of cytokine production	GO:0001817	266	0.010
regulation of ossification	GO:0030278	112	0.010
nitrogen compound transport	GO:0071705	271	0.010
jnk cascade	GO:0007254	72	0.010
ribonucleoside monophosphate metabolic process	GO:0009161	80	0.010
peptidyl lysine modification	GO:0018205	77	0.010
cellular calcium ion homeostasis	GO:0006874	119	0.010
cellular response to external stimulus	GO:0071496	88	0.010
male gamete generation	GO:0048232	285	0.010
proteasomal protein catabolic process	GO:0010498	98	0.010

Shprh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.025
cancer	DOID:162	0.025
organ system cancer	DOID:0050686	0.025
nervous system disease	DOID:863	0.013
central nervous system disease	DOID:331	0.013
disease of anatomical entity	DOID:7	0.013
musculoskeletal system disease	DOID:17	0.011

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