Mus musculus

0 known processes

Islr

immunoglobulin superfamily containing leucine-rich repeat

(Aliases: AW553146)

Islr biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
skeletal system developmentGO:00015013560.576
extracellular structure organizationGO:00430621480.562
proteoglycan metabolic processGO:0006029380.550
extracellular matrix organizationGO:00301981470.416
cartilage developmentGO:00512161400.405
regulation of angiogenesisGO:0045765810.405
connective tissue developmentGO:00614481790.397
negative regulation of tooth mineralizationGO:007017110.297
transforming growth factor beta receptor signaling pathwayGO:0007179710.284
bone developmentGO:00603481200.283
nuclear transportGO:00511691390.279
ossificationGO:00015032160.275
biomineral tissue developmentGO:0031214640.207
limb morphogenesisGO:00351081490.201
regulation of tooth mineralizationGO:007017020.195
hormone metabolic processGO:0042445860.170
camera type eye developmentGO:00430102660.163
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.162
peptidyl amino acid modificationGO:00181933360.145
regulation of hormone levelsGO:00108172110.137
chondrocyte differentiationGO:0002062720.131
positive regulation of cellular amino acid metabolic processGO:004576430.130
positive regulation of cellular amine metabolic processGO:003324050.118
embryonic organ morphogenesisGO:00485622760.116
peptidyl serine modificationGO:0018209830.112
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090101610.109
chondroitin sulfate proteoglycan metabolic processGO:0050654200.108
cellular response to growth factor stimulusGO:00713631970.107
negative regulation of transforming growth factor beta receptor signaling pathwayGO:0030512260.102
regulation of biomineral tissue developmentGO:0070167330.102
cell substrate adhesionGO:00315891300.101
aminoglycan metabolic processGO:0006022340.095
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.094
regulation of ossificationGO:00302781120.094
positive regulation of cell morphogenesis involved in differentiationGO:0010770720.093
Mouse
response to growth factorGO:00708481980.092
sulfur compound metabolic processGO:00067901000.089
insulin processingGO:003007020.089
regulation of cellular ketone metabolic processGO:0010565660.085
regulation of cell substrate adhesionGO:0010810730.084
cellular response to transforming growth factor beta stimulusGO:0071560880.084
negative regulation of cell proliferationGO:00082852960.084
forebrain developmentGO:00309003020.082
negative regulation of blood vessel morphogenesisGO:2000181250.081
skeletal system morphogenesisGO:00487052030.081
carbohydrate metabolic processGO:00059752300.077
glycosaminoglycan metabolic processGO:0030203340.077
regulation of organ morphogenesisGO:20000271440.075
blood circulationGO:00080151950.074
bone morphogenesisGO:0060349780.073
respiratory tube developmentGO:00303231670.073
mucopolysaccharide metabolic processGO:1903510250.071
response to transforming growth factor betaGO:0071559880.071
response to organic cyclic compoundGO:00140701980.071
fibril organizationGO:009743520.070
negative regulation of cellular response to growth factor stimulusGO:0090288460.069
cerebral cortex developmentGO:0021987860.069
single organism nuclear importGO:1902593950.068
positive regulation of nervous system developmentGO:00519622210.066
Mouse
chondroitin sulfate metabolic processGO:0030204170.064
bmp signaling pathwayGO:0030509930.062
regulation of transforming growth factor beta receptor signaling pathwayGO:0017015430.062
odontogenesisGO:0042476780.062
lung developmentGO:00303241640.061
nuclear importGO:0051170950.060
cytoplasmic transportGO:00164822340.059
negative regulation of odontogenesisGO:004248330.057
cellular amino acid metabolic processGO:00065201030.057
striated muscle tissue developmentGO:00147062930.056
glycoprotein metabolic processGO:00091001160.056
nucleocytoplasmic transportGO:00069131390.056
establishment of protein localization to organelleGO:00725941180.056
cell adhesionGO:00071553290.052
regulation of nucleocytoplasmic transportGO:0046822730.052
regulation of intracellular protein transportGO:0033157820.052
circulatory system processGO:00030131970.051
regulation of map kinase activityGO:00434051200.050
protein importGO:00170381010.050
regulation of protein targetingGO:1903533610.048
response to organonitrogen compoundGO:00102432460.047
ear developmentGO:00435832000.047
regulation of epithelial cell proliferationGO:00506781410.045
insulin metabolic processGO:190114230.045
negative regulation of angiogenesisGO:0016525250.045
regulation of protein bindingGO:0043393600.044
endochondral bone morphogenesisGO:0060350500.044
appendage developmentGO:00487361660.044
regulation of cellular response to growth factor stimulusGO:0090287820.044
appendage morphogenesisGO:00351071490.044
peptide cross linking via chondroitin 4 sulfate glycosaminoglycanGO:001980080.043
cellular ketone metabolic processGO:0042180840.043
cardiac chamber morphogenesisGO:0003206930.043
negative regulation of apoptotic signaling pathwayGO:20012341040.042
limb developmentGO:00601731660.042
extrinsic apoptotic signaling pathwayGO:00971911260.042
muscle tissue developmentGO:00605373080.042
regulation of proteolysisGO:00301621640.041
regulation of cytoplasmic transportGO:19036491120.041
developmental growth involved in morphogenesisGO:00605601380.041
Mouse
regulation of macrophage migration inhibitory factor signaling pathwayGO:200044610.039
cytokine productionGO:00018163190.039
digestive system developmentGO:00551232000.039
cellular modified amino acid metabolic processGO:0006575630.038
negative regulation of ossificationGO:0030279490.038
cellular response to organonitrogen compoundGO:00714171450.037
protein heterooligomerizationGO:0051291140.037
tissue remodelingGO:00487711020.037
immune effector processGO:00022523210.037
positive regulation of cell developmentGO:00107202370.036
Mouse
skin developmentGO:00435882200.036
gland developmentGO:00487323300.035
negative regulation of cellular protein metabolic processGO:00322692470.034
negative regulation of biomineral tissue developmentGO:0070168110.034
cerebellum developmentGO:0021549770.034
protein oligomerizationGO:0051259670.033
embryonic limb morphogenesisGO:00303261260.033
embryonic appendage morphogenesisGO:00351131260.032
heart morphogenesisGO:00030071780.032
sensory organ morphogenesisGO:00905962420.032
protein targetingGO:00066051430.032
negative regulation of hydrolase activityGO:0051346710.032
photoreceptor cell developmentGO:0042461400.031
organ growthGO:00352651170.031
hormone secretionGO:00468791280.030
cardiac muscle tissue developmentGO:00487381300.030
cell fate commitmentGO:00451652100.030
cellular response to vitaminGO:007129520.030
glucose metabolic processGO:0006006920.030
epithelial tube morphogenesisGO:00605623030.030
neuron migrationGO:00017641220.030
cellular response to hormone stimulusGO:00328701500.030
peptide cross linkingGO:0018149100.030
skeletal muscle organ developmentGO:00605381630.029
regulation of protein import into nucleusGO:0042306520.029
retinal blood vessel morphogenesisGO:006130430.029
regulation of protein transportGO:00512231630.029
trabecula morphogenesisGO:0061383400.029
pallium developmentGO:00215431200.029
positive regulation of hydrolase activityGO:00513451480.028
protein maturationGO:00516041760.028
defense response to other organismGO:00985421970.028
growth plate cartilage developmentGO:0003417140.028
mesenchyme developmentGO:00604851520.028
chondrocyte developmentGO:0002063240.028
acetate ester transportGO:190137420.028
muscle cell proliferationGO:0033002520.028
cardiac chamber developmentGO:00032051080.027
negative regulation of phospholipase activityGO:001051940.027
cellular amine metabolic processGO:0044106440.027
positive regulation of protein phosphorylationGO:00019342420.027
protein localization to nucleusGO:00345041210.027
regulation of cellular amino acid metabolic processGO:000652150.026
nitrogen compound transportGO:00717052710.026
regulation of cellular amine metabolic processGO:0033238200.026
positive regulation of nucleocytoplasmic transportGO:0046824300.026
positive regulation of intracellular transportGO:0032388700.026
carbohydrate biosynthetic processGO:0016051740.026
regulation of protein localizationGO:00328802310.026
positive regulation of steroid biosynthetic processGO:001089340.026
hematopoietic stem cell migrationGO:003570110.026
blood vessel morphogenesisGO:00485142850.026
response to peptideGO:19016521360.025
apical constrictionGO:000338340.025
hormone biosynthetic processGO:0042446160.025
response to oxidative stressGO:00069791230.025
fat cell differentiationGO:00454441600.025
reactive oxygen species metabolic processGO:0072593840.024
metal ion homeostasisGO:00550651890.024
regionalizationGO:00030023370.024
palate developmentGO:0060021760.024
negative regulation of vasculature developmentGO:1901343260.024
negative regulation of phosphate metabolic processGO:00459361840.024
wnt signaling pathwayGO:00160551880.024
telencephalon developmentGO:00215371860.024
amine metabolic processGO:0009308450.024
regulation of reactive oxygen species metabolic processGO:2000377400.023
regulation of cellular carbohydrate metabolic processGO:0010675750.023
early endosome to late endosome transportGO:004502220.023
intracellular protein transportGO:00068862040.023
wound healingGO:00420601570.023
cellular glucan metabolic processGO:0006073320.023
tube formationGO:00351481400.022
protein processingGO:00164851630.022
neural precursor cell proliferationGO:00613511210.022
respiratory system developmentGO:00605411900.022
positive regulation of ossificationGO:0045778470.022
regulation of blood pressureGO:0008217930.022
regulation of removal of superoxide radicalsGO:200012140.022
positive regulation of hormone secretionGO:0046887380.021
negative regulation of molecular functionGO:00440922580.021
sensory perceptionGO:00076002450.021
skeletal muscle satellite cell maintenance involved in skeletal muscle regenerationGO:001483430.021
response to peptide hormoneGO:00434341270.021
spermatogenesisGO:00072832840.021
regulation of peptidase activityGO:0052547960.021
regulation of transferase activityGO:00513382630.021
morphogenesis of embryonic epitheliumGO:00163311590.020
monocarboxylic acid metabolic processGO:00327871910.020
mesenchymal cell differentiationGO:00487621070.020
morphogenesis of a branching epitheliumGO:00611381930.020
digestive tract developmentGO:00485651900.020
embryonic skeletal system developmentGO:00487061200.020
regulation of kinase activityGO:00435492490.020
posttranscriptional regulation of gene expressionGO:00106081550.020
fibroblast proliferationGO:0048144350.019
regulation of anatomical structure sizeGO:00900661780.019
Mouse
response to extracellular stimulusGO:00099911270.019
negative regulation of cytoplasmic transportGO:1903650290.019
regulation of receptor activityGO:0010469410.019
protein import into nucleusGO:0006606950.019
regulation of bindingGO:00510981110.019
defense response to bacteriumGO:00427421190.019
regulation of cell projection organizationGO:00313442060.019
Mouse
response to acid chemicalGO:00011011110.018
positive regulation of receptor activityGO:2000273170.018
cellular response to x rayGO:007148120.018
regulation of androgen receptor signaling pathwayGO:006076530.018
negative regulation of protein metabolic processGO:00512482820.018
kidney developmentGO:00018222130.018
negative regulation of dna replicationGO:000815640.018
negative regulation of phosphorus metabolic processGO:00105631840.018
regulation of execution phase of apoptosisGO:190011790.018
positive regulation of cytokine productionGO:00018191740.018
sensory perception of mechanical stimulusGO:00509541070.018
cell type specific apoptotic processGO:00972852680.018
male gamete generationGO:00482322850.017
protein hydroxylationGO:001812640.017
bone trabecula morphogenesisGO:0061430120.017
regulation of establishment of protein localizationGO:00702011810.017
epithelial cell proliferationGO:00506731740.017
positive regulation of protein export from nucleusGO:004682740.017
regulation of cellular component biogenesisGO:00440871810.017
generation of precursor metabolites and energyGO:00060911030.017
regulation of cell adhesionGO:00301551540.017
peptide hormone secretionGO:00300721090.017
endomembrane system organizationGO:00102561470.017
negative regulation of intracellular transportGO:0032387380.017
bone trabecula formationGO:006034690.017
regulation of cytokine secretion involved in immune responseGO:000273940.017
response to insulinGO:00328681000.016
organonitrogen compound biosynthetic processGO:19015661920.016
bone mineralizationGO:0030282540.016
epithelial tube formationGO:00721751300.016
hindbrain developmentGO:00309021280.016
anatomical structure homeostasisGO:00602491450.016
negative regulation of nucleocytoplasmic transportGO:0046823230.016
cellular response to dna damage stimulusGO:00069742070.016
signal transduction in absence of ligandGO:0038034550.016
regulation of cytokine production involved in immune responseGO:0002718260.016
mineralocorticoid biosynthetic processGO:000670510.016
multicellular organism growthGO:00352641610.016
cellular metal ion homeostasisGO:00068751510.016
regulation of bmp signaling pathwayGO:0030510600.015
regulation of endopeptidase activityGO:0052548890.015
regulation of system processGO:00440572000.015
regulation of lipid metabolic processGO:00192161180.015
regulation of neuron differentiationGO:00456642810.015
Mouse
negative regulation of cell adhesionGO:0007162450.015
positive regulation of cell substrate adhesionGO:0010811470.015
small gtpase mediated signal transductionGO:0007264970.015
negative regulation of bmp signaling pathwayGO:0030514350.015
regulation of inositol phosphate biosynthetic processGO:001091930.015
regulation of glucose metabolic processGO:0010906600.015
positive regulation of intracellular protein transportGO:0090316420.015
peptidyl tyrosine modificationGO:00182121450.015
regulation of tissue remodelingGO:0034103380.015
positive regulation of smad protein import into nucleusGO:006039120.015
superoxide metabolic processGO:0006801270.014
negative regulation of protein activation cascadeGO:200025830.014
eye photoreceptor cell developmentGO:0042462310.014
positive regulation of protein modification processGO:00314012990.014
cellular ion homeostasisGO:00068731650.014
protein localization to plasma membraneGO:0072659570.014
i kappab kinase nf kappab signalingGO:0007249850.014
muscle system processGO:00030121410.014
regulation of transmembrane transportGO:00347621280.014
peripheral nervous system axon regenerationGO:001401220.014
negative regulation of camp mediated signalingGO:004395130.014
embryonic skeletal system morphogenesisGO:0048704910.014
mapk cascadeGO:00001652810.014
regulation of innate immune responseGO:0045088910.013
regulation of intracellular transportGO:00323861590.013
positive regulation of smooth muscle cell migrationGO:001491140.013
renal system developmentGO:00720012250.013
inorganic ion transmembrane transportGO:00986602340.013
termination of rna polymerase i transcriptionGO:000636320.013
innate immune responseGO:00450871570.013
regulation of hydrolase activityGO:00513362460.013
ear morphogenesisGO:00424711180.013
reactive nitrogen species metabolic processGO:200105700.013
retina development in camera type eyeGO:00600411190.013
cell divisionGO:00513011200.013
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:2001239260.013
negative regulation of endodermal cell differentiationGO:190322510.013
amide transportGO:00428861380.013
inner ear morphogenesisGO:00424721010.013
lipid biosynthetic processGO:00086101790.013
establishment or maintenance of cell polarityGO:0007163860.013
regulation of steroid hormone biosynthetic processGO:009003040.013
negative regulation of cell developmentGO:00107211690.013
mechanoreceptor differentiationGO:0042490670.013
regulation of reactive oxygen species biosynthetic processGO:190342620.013
regulation of carbohydrate metabolic processGO:0006109750.013
regenerationGO:0031099380.013
positive regulation of protein kinase b signalingGO:0051897320.013
regulation of secretion by cellGO:19035302490.013
cell killingGO:0001906670.012
canonical wnt signaling pathwayGO:00600701300.012
cell maturationGO:00484691270.012
regulation of carbohydrate biosynthetic processGO:0043255400.012
response to inorganic substanceGO:0010035960.012
hair follicle developmentGO:0001942850.012
cytokine production involved in immune responseGO:0002367340.012
aldosterone metabolic processGO:003234120.012
negative regulation of cell migrationGO:0030336590.012
vascular process in circulatory systemGO:0003018620.012
response to steroid hormoneGO:0048545560.012
hexose metabolic processGO:0019318980.012
regulation of wnt signaling pathwayGO:00301111230.012
cytokine secretionGO:0050663720.012
protein trimerizationGO:0070206130.012
interspecies interaction between organismsGO:0044419830.012
maintenance of cell numberGO:009872730.012
positive regulation of transferase activityGO:00513471670.012
negative regulation of androgen receptor signaling pathwayGO:006076630.012
cellular response to organic cyclic compoundGO:0071407870.012
regulation of mitotic cell cycleGO:00073461260.012
engulfment of apoptotic cellGO:004365230.012
transition metal ion homeostasisGO:0055076540.012
regulation of fat cell differentiationGO:0045598810.012
negative regulation of proteolysisGO:0045861740.011
smoothened signaling pathwayGO:00072241050.011
negative regulation of cell substrate adhesionGO:0010812160.011
regulation of body fluid levelsGO:00508781620.011
carbohydrate derivative biosynthetic processGO:19011371830.011
regulation of protein secretionGO:0050708820.011
regulation of protein serine threonine kinase activityGO:00719001570.011
regulation of vasculature developmentGO:1901342880.011
response to radiationGO:00093141650.011
epithelial cell differentiation involved in kidney developmentGO:0035850230.011
extracellular fibril organizationGO:004320620.011
protein localization to membraneGO:00726571080.011
digestive tract morphogenesisGO:00485461470.011
response to superoxideGO:0000303160.011
regulation of neuron apoptotic processGO:00435231220.011
production of molecular mediator of immune responseGO:00024401030.011
trabecula formationGO:0060343240.011
negative regulation of nodal signaling pathwayGO:190010830.011
response to reactive oxygen speciesGO:0000302560.011
developmental maturationGO:00217001930.011
cartilage development involved in endochondral bone morphogenesisGO:0060351240.011
regulation of nuclear divisionGO:0051783560.011
response to catecholamineGO:007186940.011
positive regulation of reactive oxygen species biosynthetic processGO:190342820.011
type b pancreatic cell proliferationGO:0044342100.011
sodium ion exportGO:007143620.011
tissue homeostasisGO:00018941150.011
negative regulation of extrinsic apoptotic signaling pathwayGO:2001237450.011
organophosphate biosynthetic processGO:00904071220.011
rho protein signal transductionGO:0007266320.011
mesenchymal cell developmentGO:0014031930.011
cellular response to lipidGO:00713961450.011
regulation of extrinsic apoptotic signaling pathwayGO:2001236770.011
cardiac septum morphogenesisGO:0060411460.011
negative regulation of epithelial cell proliferationGO:0050680640.010
stem cell differentiationGO:00488632680.010
positive regulation of protein localization to nucleusGO:1900182300.010
compound eye developmentGO:004874910.010
cellular carbohydrate metabolic processGO:00442621190.010
negative regulation of protein localization to nucleusGO:1900181230.010
single organism cell adhesionGO:00986021560.010
neuron deathGO:00709971540.010
positive regulation of neuron differentiationGO:00456661410.010
Mouse
regulation of peptidyl tyrosine phosphorylationGO:0050730930.010
symbiosis encompassing mutualism through parasitismGO:0044403830.010
cell growthGO:00160491300.010
Mouse
regulation of ion transmembrane transportGO:00347651190.010
cardiocyte differentiationGO:0035051870.010
regulation of mapk cascadeGO:00434082480.010
negative regulation of fibroblast apoptotic processGO:200027060.010
protein localization to organelleGO:00333651850.010
muscle tissue morphogenesisGO:0060415530.010
nephron developmentGO:00720061090.010
negative regulation of cellular component organizationGO:00511291940.010

Islr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.462
musculoskeletal system diseaseDOID:1700.462
connective tissue diseaseDOID:6500.223
bone diseaseDOID:008000100.161
bone development diseaseDOID:008000600.161
myopathyDOID:42300.158
muscular diseaseDOID:008000000.158
muscle tissue diseaseDOID:6600.158
collagen diseaseDOID:85400.029
congenital muscular dystrophyDOID:005055700.026
muscular dystrophyDOID:988400.026
osteochondrodysplasiaDOID:225600.015