IMP: Integrative Multi-species Prediction

Mus musculus

0 known processes

Islr

immunoglobulin superfamily containing leucine-rich repeat

(Aliases: AW553146)

Ensembl: ENSMUSG00000037206
Entrez: 26968
UniProtKB: Q6GU68

Process Predictions
Disease Predictions

Islr biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
skeletal system development	GO:0001501	356	0.576
extracellular structure organization	GO:0043062	148	0.562
proteoglycan metabolic process	GO:0006029	38	0.550
extracellular matrix organization	GO:0030198	147	0.416
cartilage development	GO:0051216	140	0.405
regulation of angiogenesis	GO:0045765	81	0.405
connective tissue development	GO:0061448	179	0.397
negative regulation of tooth mineralization	GO:0070171	1	0.297
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.284
bone development	GO:0060348	120	0.283
nuclear transport	GO:0051169	139	0.279
ossification	GO:0001503	216	0.275
biomineral tissue development	GO:0031214	64	0.207
limb morphogenesis	GO:0035108	149	0.201
regulation of tooth mineralization	GO:0070170	2	0.195
hormone metabolic process	GO:0042445	86	0.170
camera type eye development	GO:0043010	266	0.163
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.162
peptidyl amino acid modification	GO:0018193	336	0.145
regulation of hormone levels	GO:0010817	211	0.137
chondrocyte differentiation	GO:0002062	72	0.131
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.130
positive regulation of cellular amine metabolic process	GO:0033240	5	0.118
embryonic organ morphogenesis	GO:0048562	276	0.116
peptidyl serine modification	GO:0018209	83	0.112
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.109
chondroitin sulfate proteoglycan metabolic process	GO:0050654	20	0.108
cellular response to growth factor stimulus	GO:0071363	197	0.107
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.102
regulation of biomineral tissue development	GO:0070167	33	0.102
cell substrate adhesion	GO:0031589	130	0.101
aminoglycan metabolic process	GO:0006022	34	0.095
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.094
regulation of ossification	GO:0030278	112	0.094
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.093	Mouse
response to growth factor	GO:0070848	198	0.092
sulfur compound metabolic process	GO:0006790	100	0.089
insulin processing	GO:0030070	2	0.089
regulation of cellular ketone metabolic process	GO:0010565	66	0.085
regulation of cell substrate adhesion	GO:0010810	73	0.084
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.084
negative regulation of cell proliferation	GO:0008285	296	0.084
forebrain development	GO:0030900	302	0.082
negative regulation of blood vessel morphogenesis	GO:2000181	25	0.081
skeletal system morphogenesis	GO:0048705	203	0.081
carbohydrate metabolic process	GO:0005975	230	0.077
glycosaminoglycan metabolic process	GO:0030203	34	0.077
regulation of organ morphogenesis	GO:2000027	144	0.075
blood circulation	GO:0008015	195	0.074
bone morphogenesis	GO:0060349	78	0.073
respiratory tube development	GO:0030323	167	0.073
mucopolysaccharide metabolic process	GO:1903510	25	0.071
response to transforming growth factor beta	GO:0071559	88	0.071
response to organic cyclic compound	GO:0014070	198	0.071
fibril organization	GO:0097435	2	0.070
negative regulation of cellular response to growth factor stimulus	GO:0090288	46	0.069
cerebral cortex development	GO:0021987	86	0.069
single organism nuclear import	GO:1902593	95	0.068
positive regulation of nervous system development	GO:0051962	221	0.066	Mouse
chondroitin sulfate metabolic process	GO:0030204	17	0.064
bmp signaling pathway	GO:0030509	93	0.062
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.062
odontogenesis	GO:0042476	78	0.062
lung development	GO:0030324	164	0.061
nuclear import	GO:0051170	95	0.060
cytoplasmic transport	GO:0016482	234	0.059
negative regulation of odontogenesis	GO:0042483	3	0.057
cellular amino acid metabolic process	GO:0006520	103	0.057
striated muscle tissue development	GO:0014706	293	0.056
glycoprotein metabolic process	GO:0009100	116	0.056
nucleocytoplasmic transport	GO:0006913	139	0.056
establishment of protein localization to organelle	GO:0072594	118	0.056
cell adhesion	GO:0007155	329	0.052
regulation of nucleocytoplasmic transport	GO:0046822	73	0.052
regulation of intracellular protein transport	GO:0033157	82	0.052
circulatory system process	GO:0003013	197	0.051
regulation of map kinase activity	GO:0043405	120	0.050
protein import	GO:0017038	101	0.050
regulation of protein targeting	GO:1903533	61	0.048
response to organonitrogen compound	GO:0010243	246	0.047
ear development	GO:0043583	200	0.047
regulation of epithelial cell proliferation	GO:0050678	141	0.045
insulin metabolic process	GO:1901142	3	0.045
negative regulation of angiogenesis	GO:0016525	25	0.045
regulation of protein binding	GO:0043393	60	0.044
endochondral bone morphogenesis	GO:0060350	50	0.044
appendage development	GO:0048736	166	0.044
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.044
appendage morphogenesis	GO:0035107	149	0.044
peptide cross linking via chondroitin 4 sulfate glycosaminoglycan	GO:0019800	8	0.043
cellular ketone metabolic process	GO:0042180	84	0.043
cardiac chamber morphogenesis	GO:0003206	93	0.043
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.042
limb development	GO:0060173	166	0.042
extrinsic apoptotic signaling pathway	GO:0097191	126	0.042
muscle tissue development	GO:0060537	308	0.042
regulation of proteolysis	GO:0030162	164	0.041
regulation of cytoplasmic transport	GO:1903649	112	0.041
developmental growth involved in morphogenesis	GO:0060560	138	0.041	Mouse
regulation of macrophage migration inhibitory factor signaling pathway	GO:2000446	1	0.039
cytokine production	GO:0001816	319	0.039
digestive system development	GO:0055123	200	0.039
cellular modified amino acid metabolic process	GO:0006575	63	0.038
negative regulation of ossification	GO:0030279	49	0.038
cellular response to organonitrogen compound	GO:0071417	145	0.037
protein heterooligomerization	GO:0051291	14	0.037
tissue remodeling	GO:0048771	102	0.037
immune effector process	GO:0002252	321	0.037
positive regulation of cell development	GO:0010720	237	0.036	Mouse
skin development	GO:0043588	220	0.036
gland development	GO:0048732	330	0.035
negative regulation of cellular protein metabolic process	GO:0032269	247	0.034
negative regulation of biomineral tissue development	GO:0070168	11	0.034
cerebellum development	GO:0021549	77	0.034
protein oligomerization	GO:0051259	67	0.033
embryonic limb morphogenesis	GO:0030326	126	0.033
embryonic appendage morphogenesis	GO:0035113	126	0.032
heart morphogenesis	GO:0003007	178	0.032
sensory organ morphogenesis	GO:0090596	242	0.032
protein targeting	GO:0006605	143	0.032
negative regulation of hydrolase activity	GO:0051346	71	0.032
photoreceptor cell development	GO:0042461	40	0.031
organ growth	GO:0035265	117	0.031
hormone secretion	GO:0046879	128	0.030
cardiac muscle tissue development	GO:0048738	130	0.030
cell fate commitment	GO:0045165	210	0.030
cellular response to vitamin	GO:0071295	2	0.030
glucose metabolic process	GO:0006006	92	0.030
epithelial tube morphogenesis	GO:0060562	303	0.030
neuron migration	GO:0001764	122	0.030
cellular response to hormone stimulus	GO:0032870	150	0.030
peptide cross linking	GO:0018149	10	0.030
skeletal muscle organ development	GO:0060538	163	0.029
regulation of protein import into nucleus	GO:0042306	52	0.029
retinal blood vessel morphogenesis	GO:0061304	3	0.029
regulation of protein transport	GO:0051223	163	0.029
trabecula morphogenesis	GO:0061383	40	0.029
pallium development	GO:0021543	120	0.029
positive regulation of hydrolase activity	GO:0051345	148	0.028
protein maturation	GO:0051604	176	0.028
defense response to other organism	GO:0098542	197	0.028
growth plate cartilage development	GO:0003417	14	0.028
mesenchyme development	GO:0060485	152	0.028
chondrocyte development	GO:0002063	24	0.028
acetate ester transport	GO:1901374	2	0.028
muscle cell proliferation	GO:0033002	52	0.028
cardiac chamber development	GO:0003205	108	0.027
negative regulation of phospholipase activity	GO:0010519	4	0.027
cellular amine metabolic process	GO:0044106	44	0.027
positive regulation of protein phosphorylation	GO:0001934	242	0.027
protein localization to nucleus	GO:0034504	121	0.027
regulation of cellular amino acid metabolic process	GO:0006521	5	0.026
nitrogen compound transport	GO:0071705	271	0.026
regulation of cellular amine metabolic process	GO:0033238	20	0.026
positive regulation of nucleocytoplasmic transport	GO:0046824	30	0.026
positive regulation of intracellular transport	GO:0032388	70	0.026
carbohydrate biosynthetic process	GO:0016051	74	0.026
regulation of protein localization	GO:0032880	231	0.026
positive regulation of steroid biosynthetic process	GO:0010893	4	0.026
hematopoietic stem cell migration	GO:0035701	1	0.026
blood vessel morphogenesis	GO:0048514	285	0.026
response to peptide	GO:1901652	136	0.025
apical constriction	GO:0003383	4	0.025
hormone biosynthetic process	GO:0042446	16	0.025
response to oxidative stress	GO:0006979	123	0.025
fat cell differentiation	GO:0045444	160	0.025
reactive oxygen species metabolic process	GO:0072593	84	0.024
metal ion homeostasis	GO:0055065	189	0.024
regionalization	GO:0003002	337	0.024
palate development	GO:0060021	76	0.024
negative regulation of vasculature development	GO:1901343	26	0.024
negative regulation of phosphate metabolic process	GO:0045936	184	0.024
wnt signaling pathway	GO:0016055	188	0.024
telencephalon development	GO:0021537	186	0.024
amine metabolic process	GO:0009308	45	0.024
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.023
regulation of cellular carbohydrate metabolic process	GO:0010675	75	0.023
early endosome to late endosome transport	GO:0045022	2	0.023
intracellular protein transport	GO:0006886	204	0.023
wound healing	GO:0042060	157	0.023
cellular glucan metabolic process	GO:0006073	32	0.023
tube formation	GO:0035148	140	0.022
protein processing	GO:0016485	163	0.022
neural precursor cell proliferation	GO:0061351	121	0.022
respiratory system development	GO:0060541	190	0.022
positive regulation of ossification	GO:0045778	47	0.022
regulation of blood pressure	GO:0008217	93	0.022
regulation of removal of superoxide radicals	GO:2000121	4	0.022
positive regulation of hormone secretion	GO:0046887	38	0.021
negative regulation of molecular function	GO:0044092	258	0.021
sensory perception	GO:0007600	245	0.021
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	GO:0014834	3	0.021
response to peptide hormone	GO:0043434	127	0.021
spermatogenesis	GO:0007283	284	0.021
regulation of peptidase activity	GO:0052547	96	0.021
regulation of transferase activity	GO:0051338	263	0.021
morphogenesis of embryonic epithelium	GO:0016331	159	0.020
monocarboxylic acid metabolic process	GO:0032787	191	0.020
mesenchymal cell differentiation	GO:0048762	107	0.020
morphogenesis of a branching epithelium	GO:0061138	193	0.020
digestive tract development	GO:0048565	190	0.020
embryonic skeletal system development	GO:0048706	120	0.020
regulation of kinase activity	GO:0043549	249	0.020
posttranscriptional regulation of gene expression	GO:0010608	155	0.020
fibroblast proliferation	GO:0048144	35	0.019
regulation of anatomical structure size	GO:0090066	178	0.019	Mouse
response to extracellular stimulus	GO:0009991	127	0.019
negative regulation of cytoplasmic transport	GO:1903650	29	0.019
regulation of receptor activity	GO:0010469	41	0.019
protein import into nucleus	GO:0006606	95	0.019
regulation of binding	GO:0051098	111	0.019
defense response to bacterium	GO:0042742	119	0.019
regulation of cell projection organization	GO:0031344	206	0.019	Mouse
response to acid chemical	GO:0001101	111	0.018
positive regulation of receptor activity	GO:2000273	17	0.018
cellular response to x ray	GO:0071481	2	0.018
regulation of androgen receptor signaling pathway	GO:0060765	3	0.018
negative regulation of protein metabolic process	GO:0051248	282	0.018
kidney development	GO:0001822	213	0.018
negative regulation of dna replication	GO:0008156	4	0.018
negative regulation of phosphorus metabolic process	GO:0010563	184	0.018
regulation of execution phase of apoptosis	GO:1900117	9	0.018
positive regulation of cytokine production	GO:0001819	174	0.018
sensory perception of mechanical stimulus	GO:0050954	107	0.018
cell type specific apoptotic process	GO:0097285	268	0.018
male gamete generation	GO:0048232	285	0.017
protein hydroxylation	GO:0018126	4	0.017
bone trabecula morphogenesis	GO:0061430	12	0.017
regulation of establishment of protein localization	GO:0070201	181	0.017
epithelial cell proliferation	GO:0050673	174	0.017
positive regulation of protein export from nucleus	GO:0046827	4	0.017
regulation of cellular component biogenesis	GO:0044087	181	0.017
generation of precursor metabolites and energy	GO:0006091	103	0.017
regulation of cell adhesion	GO:0030155	154	0.017
peptide hormone secretion	GO:0030072	109	0.017
endomembrane system organization	GO:0010256	147	0.017
negative regulation of intracellular transport	GO:0032387	38	0.017
bone trabecula formation	GO:0060346	9	0.017
regulation of cytokine secretion involved in immune response	GO:0002739	4	0.017
response to insulin	GO:0032868	100	0.016
organonitrogen compound biosynthetic process	GO:1901566	192	0.016
bone mineralization	GO:0030282	54	0.016
epithelial tube formation	GO:0072175	130	0.016
hindbrain development	GO:0030902	128	0.016
anatomical structure homeostasis	GO:0060249	145	0.016
negative regulation of nucleocytoplasmic transport	GO:0046823	23	0.016
cellular response to dna damage stimulus	GO:0006974	207	0.016
signal transduction in absence of ligand	GO:0038034	55	0.016
regulation of cytokine production involved in immune response	GO:0002718	26	0.016
mineralocorticoid biosynthetic process	GO:0006705	1	0.016
multicellular organism growth	GO:0035264	161	0.016
cellular metal ion homeostasis	GO:0006875	151	0.016
regulation of bmp signaling pathway	GO:0030510	60	0.015
regulation of endopeptidase activity	GO:0052548	89	0.015
regulation of system process	GO:0044057	200	0.015
regulation of lipid metabolic process	GO:0019216	118	0.015
regulation of neuron differentiation	GO:0045664	281	0.015	Mouse
negative regulation of cell adhesion	GO:0007162	45	0.015
positive regulation of cell substrate adhesion	GO:0010811	47	0.015
small gtpase mediated signal transduction	GO:0007264	97	0.015
negative regulation of bmp signaling pathway	GO:0030514	35	0.015
regulation of inositol phosphate biosynthetic process	GO:0010919	3	0.015
regulation of glucose metabolic process	GO:0010906	60	0.015
positive regulation of intracellular protein transport	GO:0090316	42	0.015
peptidyl tyrosine modification	GO:0018212	145	0.015
regulation of tissue remodeling	GO:0034103	38	0.015
positive regulation of smad protein import into nucleus	GO:0060391	2	0.015
superoxide metabolic process	GO:0006801	27	0.014
negative regulation of protein activation cascade	GO:2000258	3	0.014
eye photoreceptor cell development	GO:0042462	31	0.014
positive regulation of protein modification process	GO:0031401	299	0.014
cellular ion homeostasis	GO:0006873	165	0.014
protein localization to plasma membrane	GO:0072659	57	0.014
i kappab kinase nf kappab signaling	GO:0007249	85	0.014
muscle system process	GO:0003012	141	0.014
regulation of transmembrane transport	GO:0034762	128	0.014
peripheral nervous system axon regeneration	GO:0014012	2	0.014
negative regulation of camp mediated signaling	GO:0043951	3	0.014
embryonic skeletal system morphogenesis	GO:0048704	91	0.014
mapk cascade	GO:0000165	281	0.014
regulation of innate immune response	GO:0045088	91	0.013
regulation of intracellular transport	GO:0032386	159	0.013
positive regulation of smooth muscle cell migration	GO:0014911	4	0.013
renal system development	GO:0072001	225	0.013
inorganic ion transmembrane transport	GO:0098660	234	0.013
termination of rna polymerase i transcription	GO:0006363	2	0.013
innate immune response	GO:0045087	157	0.013
regulation of hydrolase activity	GO:0051336	246	0.013
ear morphogenesis	GO:0042471	118	0.013
reactive nitrogen species metabolic process	GO:2001057	0	0.013
retina development in camera type eye	GO:0060041	119	0.013
cell division	GO:0051301	120	0.013
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.013
negative regulation of endodermal cell differentiation	GO:1903225	1	0.013
amide transport	GO:0042886	138	0.013
inner ear morphogenesis	GO:0042472	101	0.013
lipid biosynthetic process	GO:0008610	179	0.013
establishment or maintenance of cell polarity	GO:0007163	86	0.013
regulation of steroid hormone biosynthetic process	GO:0090030	4	0.013
negative regulation of cell development	GO:0010721	169	0.013
mechanoreceptor differentiation	GO:0042490	67	0.013
regulation of reactive oxygen species biosynthetic process	GO:1903426	2	0.013
regulation of carbohydrate metabolic process	GO:0006109	75	0.013
regeneration	GO:0031099	38	0.013
positive regulation of protein kinase b signaling	GO:0051897	32	0.013
regulation of secretion by cell	GO:1903530	249	0.013
cell killing	GO:0001906	67	0.012
canonical wnt signaling pathway	GO:0060070	130	0.012
cell maturation	GO:0048469	127	0.012
regulation of carbohydrate biosynthetic process	GO:0043255	40	0.012
response to inorganic substance	GO:0010035	96	0.012
hair follicle development	GO:0001942	85	0.012
cytokine production involved in immune response	GO:0002367	34	0.012
aldosterone metabolic process	GO:0032341	2	0.012
negative regulation of cell migration	GO:0030336	59	0.012
vascular process in circulatory system	GO:0003018	62	0.012
response to steroid hormone	GO:0048545	56	0.012
hexose metabolic process	GO:0019318	98	0.012
regulation of wnt signaling pathway	GO:0030111	123	0.012
cytokine secretion	GO:0050663	72	0.012
protein trimerization	GO:0070206	13	0.012
interspecies interaction between organisms	GO:0044419	83	0.012
maintenance of cell number	GO:0098727	3	0.012
positive regulation of transferase activity	GO:0051347	167	0.012
negative regulation of androgen receptor signaling pathway	GO:0060766	3	0.012
cellular response to organic cyclic compound	GO:0071407	87	0.012
regulation of mitotic cell cycle	GO:0007346	126	0.012
engulfment of apoptotic cell	GO:0043652	3	0.012
transition metal ion homeostasis	GO:0055076	54	0.012
regulation of fat cell differentiation	GO:0045598	81	0.012
negative regulation of proteolysis	GO:0045861	74	0.011
smoothened signaling pathway	GO:0007224	105	0.011
negative regulation of cell substrate adhesion	GO:0010812	16	0.011
regulation of body fluid levels	GO:0050878	162	0.011
carbohydrate derivative biosynthetic process	GO:1901137	183	0.011
regulation of protein secretion	GO:0050708	82	0.011
regulation of protein serine threonine kinase activity	GO:0071900	157	0.011
regulation of vasculature development	GO:1901342	88	0.011
response to radiation	GO:0009314	165	0.011
epithelial cell differentiation involved in kidney development	GO:0035850	23	0.011
extracellular fibril organization	GO:0043206	2	0.011
protein localization to membrane	GO:0072657	108	0.011
digestive tract morphogenesis	GO:0048546	147	0.011
response to superoxide	GO:0000303	16	0.011
regulation of neuron apoptotic process	GO:0043523	122	0.011
production of molecular mediator of immune response	GO:0002440	103	0.011
trabecula formation	GO:0060343	24	0.011
negative regulation of nodal signaling pathway	GO:1900108	3	0.011
response to reactive oxygen species	GO:0000302	56	0.011
developmental maturation	GO:0021700	193	0.011
cartilage development involved in endochondral bone morphogenesis	GO:0060351	24	0.011
regulation of nuclear division	GO:0051783	56	0.011
response to catecholamine	GO:0071869	4	0.011
positive regulation of reactive oxygen species biosynthetic process	GO:1903428	2	0.011
type b pancreatic cell proliferation	GO:0044342	10	0.011
sodium ion export	GO:0071436	2	0.011
tissue homeostasis	GO:0001894	115	0.011
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.011
organophosphate biosynthetic process	GO:0090407	122	0.011
rho protein signal transduction	GO:0007266	32	0.011
mesenchymal cell development	GO:0014031	93	0.011
cellular response to lipid	GO:0071396	145	0.011
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.011
cardiac septum morphogenesis	GO:0060411	46	0.011
negative regulation of epithelial cell proliferation	GO:0050680	64	0.010
stem cell differentiation	GO:0048863	268	0.010
positive regulation of protein localization to nucleus	GO:1900182	30	0.010
compound eye development	GO:0048749	1	0.010
cellular carbohydrate metabolic process	GO:0044262	119	0.010
negative regulation of protein localization to nucleus	GO:1900181	23	0.010
single organism cell adhesion	GO:0098602	156	0.010
neuron death	GO:0070997	154	0.010
positive regulation of neuron differentiation	GO:0045666	141	0.010	Mouse
regulation of peptidyl tyrosine phosphorylation	GO:0050730	93	0.010
symbiosis encompassing mutualism through parasitism	GO:0044403	83	0.010
cell growth	GO:0016049	130	0.010	Mouse
regulation of ion transmembrane transport	GO:0034765	119	0.010
cardiocyte differentiation	GO:0035051	87	0.010
regulation of mapk cascade	GO:0043408	248	0.010
negative regulation of fibroblast apoptotic process	GO:2000270	6	0.010
protein localization to organelle	GO:0033365	185	0.010
muscle tissue morphogenesis	GO:0060415	53	0.010
nephron development	GO:0072006	109	0.010
negative regulation of cellular component organization	GO:0051129	194	0.010

Islr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.462
musculoskeletal system disease	DOID:17	0.462
connective tissue disease	DOID:65	0.223
bone disease	DOID:0080001	0.161
bone development disease	DOID:0080006	0.161
myopathy	DOID:423	0.158
muscular disease	DOID:0080000	0.158
muscle tissue disease	DOID:66	0.158
collagen disease	DOID:854	0.029
congenital muscular dystrophy	DOID:0050557	0.026
muscular dystrophy	DOID:9884	0.026
osteochondrodysplasia	DOID:2256	0.015

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