IMP: Integrative Multi-species Prediction

Mus musculus

76 known processes

Isl2

insulin related protein 2 (islet 2)

(Aliases: 3110001N10Rik,MGC171130)

Ensembl: ENSMUSG00000032318
Entrez: 104360
UniProtKB: Q9CXV0
UniProtKB: Q0VAX2

Process Predictions
Disease Predictions

Isl2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regionalization	GO:0003002	337	0.863	Mouse Fly
sensory organ morphogenesis	GO:0090596	242	0.831	Mouse
camera type eye development	GO:0043010	266	0.715	Mouse
chemotaxis	GO:0006935	247	0.683
skeletal system development	GO:0001501	356	0.634	Mouse
ear morphogenesis	GO:0042471	118	0.577
diencephalon development	GO:0021536	63	0.551	Mouse
limb morphogenesis	GO:0035108	149	0.506	Mouse
urogenital system development	GO:0001655	261	0.503	Mouse
hindbrain development	GO:0030902	128	0.502	Mouse
neural tube development	GO:0021915	160	0.480	Mouse
skeletal system morphogenesis	GO:0048705	203	0.468	Mouse
spinal cord development	GO:0021510	81	0.453
renal system development	GO:0072001	225	0.447	Mouse
regulation of organ morphogenesis	GO:2000027	144	0.442	Mouse
ear development	GO:0043583	200	0.389
forebrain development	GO:0030900	302	0.384	Mouse
cell fate commitment	GO:0045165	210	0.374
embryonic organ morphogenesis	GO:0048562	276	0.374	Mouse
axonogenesis	GO:0007409	274	0.344
central nervous system neuron differentiation	GO:0021953	162	0.333
neuron migration	GO:0001764	122	0.333	Mouse
appendage morphogenesis	GO:0035107	149	0.331	Mouse
inner ear morphogenesis	GO:0042472	101	0.327
cellular amino acid metabolic process	GO:0006520	103	0.327
regulation of neuron differentiation	GO:0045664	281	0.322
tube closure	GO:0060606	91	0.315	Mouse
spinal cord motor neuron differentiation	GO:0021522	35	0.313
striated muscle tissue development	GO:0014706	293	0.311	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.311
formation of primary germ layer	GO:0001704	77	0.303	Mouse
cell differentiation in spinal cord	GO:0021515	53	0.296
ectoderm formation	GO:0001705	3	0.294	Mouse
neural tube closure	GO:0001843	90	0.293	Mouse
skin development	GO:0043588	220	0.292	Mouse
axon guidance	GO:0007411	141	0.284
gastrulation	GO:0007369	116	0.281	Mouse
gland development	GO:0048732	330	0.279	Mouse Fly
epithelial tube formation	GO:0072175	130	0.263	Mouse
central nervous system projection neuron axonogenesis	GO:0021952	21	0.263
epithelial tube morphogenesis	GO:0060562	303	0.261	Mouse
neural tube formation	GO:0001841	108	0.256	Mouse
tumor necrosis factor production	GO:0032640	50	0.248	Mouse
eye photoreceptor cell differentiation	GO:0001754	41	0.248
retina morphogenesis in camera type eye	GO:0060042	45	0.246	Mouse
regulation of acetylcholine secretion neurotransmission	GO:0014056	2	0.233
primary neural tube formation	GO:0014020	95	0.231	Mouse
sensory perception of sound	GO:0007605	97	0.230
stem cell differentiation	GO:0048863	268	0.217	Mouse
neuron fate specification	GO:0048665	30	0.216
endocrine system development	GO:0035270	98	0.215	Mouse
bmp signaling pathway	GO:0030509	93	0.215
cellular amine metabolic process	GO:0044106	44	0.214
positive regulation of neuron differentiation	GO:0045666	141	0.209
neural retina development	GO:0003407	41	0.208	Mouse
epidermis development	GO:0008544	187	0.208	Mouse
negative regulation of nervous system development	GO:0051961	156	0.206
leukocyte differentiation	GO:0002521	342	0.205
histone modification	GO:0016570	159	0.202
canonical wnt signaling pathway	GO:0060070	130	0.201	Mouse
retina development in camera type eye	GO:0060041	119	0.200	Mouse
morphogenesis of embryonic epithelium	GO:0016331	159	0.197	Mouse Fly
palate development	GO:0060021	76	0.192
chromatin modification	GO:0016568	187	0.189
blood vessel morphogenesis	GO:0048514	285	0.189	Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.189
cardiac septum development	GO:0003279	59	0.187	Mouse
lateral geniculate nucleus development	GO:0021771	1	0.187
cerebral cortex development	GO:0021987	86	0.186	Mouse
positive regulation of dopamine secretion	GO:0033603	2	0.186
mesenchymal cell differentiation	GO:0048762	107	0.181	Mouse
amine metabolic process	GO:0009308	45	0.177
motor neuron migration	GO:0097475	4	0.175	Mouse
digestive tract morphogenesis	GO:0048546	147	0.174	Mouse
cartilage development	GO:0051216	140	0.173
negative regulation of action potential	GO:0045759	1	0.170
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.165
cell maturation	GO:0048469	127	0.165	Mouse
limbic system development	GO:0021761	72	0.159	Mouse
regulation of heart contraction	GO:0008016	77	0.158
cardiac chamber morphogenesis	GO:0003206	93	0.155	Mouse
negative regulation of neuron differentiation	GO:0045665	101	0.153
peptidyl amino acid modification	GO:0018193	336	0.151	Mouse
developmental growth involved in morphogenesis	GO:0060560	138	0.150	Zebrafish Mouse
synaptic transmission involved in micturition	GO:0060084	3	0.149
mesoderm morphogenesis	GO:0048332	64	0.146
muscle cell differentiation	GO:0042692	261	0.146	Mouse Fly
central nervous system neuron axonogenesis	GO:0021955	28	0.145
appendage development	GO:0048736	166	0.144	Mouse
embryonic digit morphogenesis	GO:0042733	56	0.144
central nervous system neuron development	GO:0021954	67	0.144	Mouse
pancreatic pp cell fate commitment	GO:0003329	2	0.142
sensory perception of mechanical stimulus	GO:0050954	107	0.140
embryonic epithelial tube formation	GO:0001838	130	0.140	Mouse
embryonic appendage morphogenesis	GO:0035113	126	0.140
embryonic skeletal system morphogenesis	GO:0048704	91	0.139	Mouse
visceral motor neuron differentiation	GO:0021524	3	0.138
kidney development	GO:0001822	213	0.136	Mouse
b cell activation	GO:0042113	161	0.134
segmentation	GO:0035282	93	0.133	Mouse Fly
pituitary gland development	GO:0021983	38	0.132	Mouse
cerebral cortex radially oriented cell migration	GO:0021799	31	0.132	Mouse
sensory perception	GO:0007600	245	0.131
mesoderm formation	GO:0001707	62	0.131
regulation of circadian sleep wake cycle rem sleep	GO:0042320	1	0.131
stem cell development	GO:0048864	219	0.130	Mouse
skeletal muscle organ development	GO:0060538	163	0.130
neuron projection guidance	GO:0097485	141	0.126
mesenchymal cell development	GO:0014031	93	0.126	Mouse
embryonic limb morphogenesis	GO:0030326	126	0.125
neural nucleus development	GO:0048857	22	0.125
response to growth factor	GO:0070848	198	0.122
molting cycle	GO:0042303	90	0.119	Mouse
muscle tissue development	GO:0060537	308	0.117	Mouse
endoderm development	GO:0007492	45	0.115	Mouse
olfactory bulb development	GO:0021772	30	0.113	Mouse
lymphocyte differentiation	GO:0030098	242	0.113
regulation of cellular amino acid metabolic process	GO:0006521	5	0.113
angiogenesis	GO:0001525	201	0.113	Mouse
nerve development	GO:0021675	67	0.112	Mouse
chromatin organization	GO:0006325	206	0.112
ventricular cardiac muscle tissue development	GO:0003229	38	0.111	Mouse
synaptic transmission	GO:0007268	329	0.110
pancreatic a cell fate commitment	GO:0003326	2	0.110
digestive system development	GO:0055123	200	0.110	Zebrafish Mouse Worm
telencephalon development	GO:0021537	186	0.110	Mouse
chondrocyte differentiation	GO:0002062	72	0.109
tube formation	GO:0035148	140	0.108	Mouse
embryonic skeletal system development	GO:0048706	120	0.108	Mouse
positive regulation of nervous system development	GO:0051962	221	0.108	Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.107	Fly
olfactory lobe development	GO:0021988	32	0.107	Mouse
skeletal muscle cell differentiation	GO:0035914	66	0.106
baroreceptor response to decreased systemic arterial blood pressure	GO:0001982	2	0.106
positive regulation of cell development	GO:0010720	237	0.105
myeloid cell differentiation	GO:0030099	233	0.104
ovulation cycle	GO:0042698	59	0.103
negative regulation of cell development	GO:0010721	169	0.103
dendrite development	GO:0016358	115	0.101	Fly
acetylcholine secretion neurotransmission	GO:0014055	2	0.101
positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	GO:0001988	1	0.100
cardiac chamber development	GO:0003205	108	0.100	Mouse
limb development	GO:0060173	166	0.099	Mouse
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.099	Mouse
stem cell maintenance	GO:0019827	130	0.098
extracellular structure organization	GO:0043062	148	0.098	Mouse
regulation of bmp signaling pathway	GO:0030510	60	0.096
covalent chromatin modification	GO:0016569	163	0.095
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.094
cell adhesion	GO:0007155	329	0.093
pancreatic pp cell differentiation	GO:0003312	2	0.092
connective tissue development	GO:0061448	179	0.092
mesoderm development	GO:0007498	100	0.090	Mouse
cranial nerve development	GO:0021545	41	0.090	Mouse
cellular response to growth factor stimulus	GO:0071363	197	0.090
negative regulation of wnt signaling pathway	GO:0030178	73	0.089	Mouse
hair follicle development	GO:0001942	85	0.089	Mouse
neuron apoptotic process	GO:0051402	142	0.089	Mouse
muscle tissue morphogenesis	GO:0060415	53	0.088	Mouse
epithelial cell development	GO:0002064	159	0.088
regulation of neuron projection development	GO:0010975	169	0.087
regulation of myeloid cell differentiation	GO:0045637	96	0.086
cytokine production	GO:0001816	319	0.086	Mouse
circadian sleep wake cycle rem sleep	GO:0042747	1	0.085
neural crest cell differentiation	GO:0014033	54	0.083	Mouse
mechanoreceptor differentiation	GO:0042490	67	0.083
ion transmembrane transport	GO:0034220	361	0.083
autonomic nervous system development	GO:0048483	43	0.082
spinal cord oligodendrocyte cell fate specification	GO:0021530	3	0.082
norepinephrine transport	GO:0015874	2	0.082
positive regulation of nephron tubule epithelial cell differentiation	GO:2000768	1	0.081	Mouse
activation of transmembrane receptor protein tyrosine kinase activity	GO:0007171	3	0.081
male sex differentiation	GO:0046661	109	0.081	Mouse
auditory receptor cell fate specification	GO:0042667	1	0.080
renal tubule development	GO:0061326	87	0.079	Mouse
peripheral nervous system neuron axonogenesis	GO:0048936	3	0.079	Mouse
regulation of interleukin 6 production	GO:0032675	55	0.079	Mouse
nephron epithelium morphogenesis	GO:0072088	68	0.079	Mouse
hematopoietic progenitor cell differentiation	GO:0002244	143	0.078
acetate ester transport	GO:1901374	2	0.077
ventral spinal cord interneuron differentiation	GO:0021514	16	0.076	Mouse
hair cycle	GO:0042633	90	0.076	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.076
action potential	GO:0001508	78	0.076
uterine epithelium development	GO:0035847	1	0.075	Mouse
homeostasis of number of cells	GO:0048872	210	0.075
development of primary sexual characteristics	GO:0045137	143	0.075	Mouse Worm
astrocyte fate commitment	GO:0060018	4	0.075
development of primary male sexual characteristics	GO:0046546	88	0.074	Mouse
cardiac septum morphogenesis	GO:0060411	46	0.073	Mouse
mesenchyme development	GO:0060485	152	0.073	Mouse
wnt signaling pathway	GO:0016055	188	0.073	Mouse
regulation of cell motility	GO:2000145	236	0.072
regulation of organelle organization	GO:0033043	289	0.072
negative regulation of neuron death	GO:1901215	98	0.072	Mouse
cell proliferation in hindbrain	GO:0021534	10	0.072
odontogenesis	GO:0042476	78	0.071	Mouse
female gonad development	GO:0008585	71	0.071	Mouse
regulation of anterior head development	GO:2000742	2	0.070	Mouse
development of primary female sexual characteristics	GO:0046545	73	0.070	Mouse
oviduct development	GO:0060066	3	0.070	Mouse
inner ear receptor cell differentiation	GO:0060113	61	0.070
somatotropin secreting cell differentiation	GO:0060126	4	0.069
gonad development	GO:0008406	141	0.069	Mouse Worm
heart contraction	GO:0060047	93	0.069
regulation of cell migration	GO:0030334	219	0.068
somite development	GO:0061053	81	0.068	Mouse
generation of ovulation cycle rhythm	GO:0060112	1	0.066
extracellular matrix organization	GO:0030198	147	0.066	Mouse
regulation of tumor necrosis factor production	GO:0032680	49	0.065	Mouse
visual perception	GO:0007601	52	0.065
ureteric bud morphogenesis	GO:0060675	62	0.064	Mouse
regulation of embryonic development	GO:0045995	71	0.064	Mouse
respiratory system development	GO:0060541	190	0.064
medial motor column neuron differentiation	GO:0021526	2	0.064	Mouse
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.063
lens development in camera type eye	GO:0002088	62	0.063
regulation of membrane potential	GO:0042391	192	0.062
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.062
cerebellum development	GO:0021549	77	0.062	Mouse
bone development	GO:0060348	120	0.062
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.062	Fly
heart morphogenesis	GO:0003007	178	0.061	Mouse
endocardial cushion morphogenesis	GO:0003203	18	0.061	Mouse
histone acetylation	GO:0016573	41	0.061
neuron death	GO:0070997	154	0.061	Mouse
carbon catabolite activation of transcription from rna polymerase ii promoter	GO:0000436	4	0.061
positive regulation of protein modification process	GO:0031401	299	0.061	Mouse
collagen fibril organization	GO:0030199	32	0.061	Mouse
regulation of neural precursor cell proliferation	GO:2000177	70	0.060	Mouse
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.060	Mouse
divalent inorganic cation transport	GO:0072511	178	0.060
cerebellar purkinje cell differentiation	GO:0021702	13	0.060	Mouse
membrane organization	GO:0061024	245	0.059
negative regulation of immune system process	GO:0002683	209	0.059
metencephalon development	GO:0022037	89	0.059	Mouse
positive regulation of protein phosphorylation	GO:0001934	242	0.059	Mouse
detection of external stimulus	GO:0009581	61	0.059
endodermal cell fate specification	GO:0001714	4	0.058
somitogenesis	GO:0001756	69	0.058	Mouse
stem cell proliferation	GO:0072089	117	0.058
forebrain regionalization	GO:0021871	25	0.058	Mouse
detection of stimulus	GO:0051606	84	0.058
negative regulation of myeloid cell differentiation	GO:0045638	38	0.057
developmental cell growth	GO:0048588	84	0.057	Zebrafish Mouse
positive regulation of inner ear receptor cell differentiation	GO:2000982	1	0.057
myeloid leukocyte differentiation	GO:0002573	119	0.056
germ cell development	GO:0007281	185	0.056
negative regulation of canonical wnt signaling pathway	GO:0090090	51	0.056	Mouse
cardiac neural crest cell migration involved in outflow tract morphogenesis	GO:0003253	3	0.056
trophectodermal cell differentiation	GO:0001829	21	0.056
globus pallidus development	GO:0021759	2	0.055
positive regulation of keratinocyte proliferation	GO:0010838	4	0.055
pallium development	GO:0021543	120	0.055	Mouse
epithelial to mesenchymal transition	GO:0001837	47	0.054
detection of mechanical stimulus involved in sensory perception of sound	GO:0050910	16	0.054
regulation of histone modification	GO:0031056	56	0.054
blood vessel remodeling	GO:0001974	33	0.054
positive regulation of cellular amine metabolic process	GO:0033240	5	0.054
thalamus development	GO:0021794	11	0.054
forebrain neuron differentiation	GO:0021879	52	0.054	Mouse
multicellular organism growth	GO:0035264	161	0.053
cardiac muscle tissue development	GO:0048738	130	0.053	Mouse
regulation of norepinephrine secretion	GO:0014061	2	0.053
cerebellar cortex development	GO:0021695	48	0.053	Mouse
regulation of cell adhesion	GO:0030155	154	0.053
regulation of circadian sleep wake cycle non rem sleep	GO:0045188	1	0.053
ventral spinal cord development	GO:0021517	48	0.052
forebrain cell migration	GO:0021885	58	0.052	Mouse
regulation of neuron death	GO:1901214	134	0.052	Mouse
nuclear division	GO:0000280	158	0.052
peptidyl tyrosine modification	GO:0018212	145	0.052	Mouse
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	40	0.052	Fly
outflow tract morphogenesis	GO:0003151	53	0.051	Mouse
apoptotic signaling pathway	GO:0097190	306	0.051
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.051
paramesonephric duct development	GO:0061205	3	0.051	Mouse
forebrain neuron fate commitment	GO:0021877	13	0.050	Mouse
bundle of his development	GO:0003166	4	0.050
regulation of cell activation	GO:0050865	289	0.050
neuron projection extension	GO:1990138	64	0.050	Zebrafish Mouse
norepinephrine secretion	GO:0048243	2	0.050
auditory receptor cell differentiation	GO:0042491	37	0.050
cardiac ventricle development	GO:0003231	83	0.049	Mouse
male gonad development	GO:0008584	88	0.049	Mouse
developmental maturation	GO:0021700	193	0.049	Mouse
pancreas development	GO:0031016	57	0.049	Zebrafish Mouse
peptidyl lysine modification	GO:0018205	77	0.049
photoreceptor cell differentiation	GO:0046530	52	0.048
metanephros development	GO:0001656	79	0.048	Mouse
regulation of response to wounding	GO:1903034	189	0.048	Mouse
transmembrane transport	GO:0055085	412	0.048
positive regulation of macrophage colony stimulating factor production	GO:1901258	1	0.048	Mouse
forebrain generation of neurons	GO:0021872	63	0.048	Mouse
cervix development	GO:0060067	2	0.047	Mouse
regulation of cytokine production	GO:0001817	266	0.047	Mouse
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000800	1	0.047
blastocyst development	GO:0001824	80	0.047
cellular response to external stimulus	GO:0071496	88	0.047
notch signaling pathway	GO:0007219	71	0.046
heart process	GO:0003015	94	0.046
auditory receptor cell fate determination	GO:0042668	3	0.046
maintenance of epithelial cell apical basal polarity	GO:0045199	2	0.046	Mouse
morphogenesis of a polarized epithelium	GO:0001738	37	0.046
cell fate specification	GO:0001708	72	0.046
regulation of apoptotic signaling pathway	GO:2001233	197	0.046
negative regulation of cell proliferation	GO:0008285	296	0.045
lateral inhibition	GO:0046331	1	0.045
hypothalamus development	GO:0021854	16	0.045
morphogenesis of a branching structure	GO:0001763	203	0.044	Mouse
regulation of cell cycle	GO:0051726	281	0.044
female gamete generation	GO:0007292	74	0.044
negative regulation of neuron apoptotic process	GO:0043524	92	0.044	Mouse
ossification	GO:0001503	216	0.044
peripheral nervous system development	GO:0007422	53	0.044	Mouse
positive regulation of angiogenesis	GO:0045766	46	0.044	Mouse
organelle fission	GO:0048285	170	0.043
regulation of cell projection organization	GO:0031344	206	0.043
circadian sleep wake cycle non rem sleep	GO:0042748	2	0.043
maintenance of apical basal cell polarity	GO:0035090	3	0.043	Mouse
regulation of interleukin 1 production	GO:0032652	26	0.043	Mouse
learning or memory	GO:0007611	148	0.043	Mouse
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation	GO:2000802	1	0.043
macrophage colony stimulating factor production	GO:0036301	1	0.042	Mouse
nephron development	GO:0072006	109	0.042	Mouse
multi organism reproductive behavior	GO:0044705	29	0.042
regulation of feeding behavior	GO:0060259	3	0.042
visceral serous pericardium development	GO:0061032	2	0.042
nephron tubule morphogenesis	GO:0072078	68	0.042	Mouse
cardiac ventricle morphogenesis	GO:0003208	50	0.041	Mouse
tendon cell differentiation	GO:0035990	4	0.041
cranial nerve morphogenesis	GO:0021602	26	0.041
neural crest cell development	GO:0014032	48	0.041	Mouse
pigmentation	GO:0043473	71	0.041
hindbrain morphogenesis	GO:0021575	46	0.041	Mouse
positive regulation of auditory receptor cell differentiation	GO:0045609	1	0.041
divalent metal ion transport	GO:0070838	172	0.040
leukocyte migration	GO:0050900	124	0.040
aromatic compound catabolic process	GO:0019439	286	0.040
female sex differentiation	GO:0046660	84	0.040	Mouse
negative regulation of molecular function	GO:0044092	258	0.039	Mouse Fly
positive regulation of anterior head development	GO:2000744	2	0.039	Mouse
establishment or maintenance of cell polarity	GO:0007163	86	0.039	Mouse
regulation of wnt signaling pathway	GO:0030111	123	0.039	Mouse
b cell differentiation	GO:0030183	78	0.038
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.038
positive regulation of epithelial cell differentiation involved in kidney development	GO:2000698	2	0.038	Mouse
retinal bipolar neuron differentiation	GO:0060040	5	0.038
protein acylation	GO:0043543	64	0.038
spinal cord motor neuron cell fate specification	GO:0021520	13	0.038
endomembrane system organization	GO:0010256	147	0.038
cellular component assembly involved in morphogenesis	GO:0010927	139	0.037
genitalia development	GO:0048806	37	0.037	Mouse
lateral motor column neuron migration	GO:0097477	3	0.037	Mouse
determination of left right symmetry	GO:0007368	80	0.037
spermatogenesis	GO:0007283	284	0.037
regulation of neuron apoptotic process	GO:0043523	122	0.036	Mouse
midbrain development	GO:0030901	35	0.036	Mouse
positive regulation of stem cell differentiation	GO:2000738	23	0.036
regulation of stem cell proliferation	GO:0072091	78	0.036
hair cell differentiation	GO:0035315	40	0.036
negative regulation of dna binding	GO:0043392	20	0.036	Mouse
head morphogenesis	GO:0060323	34	0.036	Worm
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.036
cerebral cortex cell migration	GO:0021795	44	0.036	Mouse
paraxial mesodermal cell fate commitment	GO:0048343	2	0.036
interleukin 1 beta production	GO:0032611	30	0.036	Mouse
ventral spinal cord interneuron fate commitment	GO:0060579	14	0.036	Mouse
organelle localization	GO:0051640	179	0.036
oogenesis	GO:0048477	56	0.036
negative regulation of oxidative phosphorylation uncoupler activity	GO:2000276	2	0.035
organic hydroxy compound metabolic process	GO:1901615	203	0.035
positive regulation of cell death	GO:0010942	224	0.035
neural precursor cell proliferation	GO:0061351	121	0.035	Mouse
paraxial mesodermal cell differentiation	GO:0048342	2	0.035
branching morphogenesis of an epithelial tube	GO:0048754	159	0.035	Mouse
body fluid secretion	GO:0007589	53	0.035
hippocampus development	GO:0021766	52	0.035	Mouse
regulation of transferase activity	GO:0051338	263	0.035
positive regulation of mesonephros development	GO:0061213	20	0.035	Mouse
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process	GO:2000763	1	0.035
regulation of heart morphogenesis	GO:2000826	22	0.035	Mouse
sensory perception of light stimulus	GO:0050953	54	0.035
embryonic eye morphogenesis	GO:0048048	29	0.035
mitochondrion distribution	GO:0048311	4	0.035
ras protein signal transduction	GO:0007265	77	0.035
syncytium formation by plasma membrane fusion	GO:0000768	42	0.035
mesenchyme morphogenesis	GO:0072132	32	0.034	Mouse
endocrine pancreas development	GO:0031018	29	0.034
regulation of leukocyte differentiation	GO:1902105	159	0.034
deltoid tuberosity development	GO:0035993	3	0.034
organ growth	GO:0035265	117	0.034	Mouse
regulation of cell growth	GO:0001558	91	0.034	Mouse
blastocyst formation	GO:0001825	33	0.034
regulation of angiogenesis	GO:0045765	81	0.034	Mouse
cognition	GO:0050890	149	0.034	Mouse
kidney morphogenesis	GO:0060993	83	0.033	Mouse
cardiac muscle tissue morphogenesis	GO:0055008	44	0.033	Mouse
adult behavior	GO:0030534	135	0.033
cation transmembrane transport	GO:0098655	266	0.033
spinal cord oligodendrocyte cell differentiation	GO:0021529	3	0.033
cell differentiation in hindbrain	GO:0021533	24	0.033	Mouse
cellular response to organonitrogen compound	GO:0071417	145	0.033
endoderm formation	GO:0001706	20	0.033	Mouse
membrane depolarization	GO:0051899	64	0.033
regulation of morphogenesis of a branching structure	GO:0060688	53	0.033	Mouse
neuromuscular process	GO:0050905	99	0.033
cell proliferation in external granule layer	GO:0021924	10	0.033
ameboidal type cell migration	GO:0001667	128	0.033	Mouse
acetylcholine transport	GO:0015870	2	0.032
mesodermal cell differentiation	GO:0048333	22	0.032
placenta development	GO:0001890	140	0.032	Mouse
myeloid cell homeostasis	GO:0002262	114	0.032
positive regulation of cell cycle	GO:0045787	92	0.032
spinal cord motor neuron migration	GO:0097476	4	0.032	Mouse
cerebellar purkinje cell layer development	GO:0021680	26	0.032	Mouse
positive regulation of cell motility	GO:2000147	116	0.032
locomotory behavior	GO:0007626	195	0.032
negative regulation of cellular component organization	GO:0051129	194	0.032
telencephalon regionalization	GO:0021978	14	0.031	Mouse
bone morphogenesis	GO:0060349	78	0.031
telencephalon cell migration	GO:0022029	55	0.031	Mouse
regulation of action potential	GO:0098900	4	0.031
organic cyclic compound catabolic process	GO:1901361	295	0.031
positive regulation of kidney development	GO:0090184	28	0.031	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.031
cellular response to lipid	GO:0071396	145	0.031
sperm motility	GO:0030317	47	0.031
adult locomotory behavior	GO:0008344	91	0.031
cell proliferation involved in outflow tract morphogenesis	GO:0061325	4	0.031
cellular protein complex assembly	GO:0043623	116	0.030
prostate gland morphogenesis	GO:0060512	32	0.030
rhythmic process	GO:0048511	174	0.030
regulation of muscle tissue development	GO:1901861	97	0.030
cardiocyte differentiation	GO:0035051	87	0.030	Mouse
prostate gland development	GO:0030850	48	0.030
response to transforming growth factor beta	GO:0071559	88	0.030
ureteric bud development	GO:0001657	94	0.030	Mouse
sclerotome development	GO:0061056	4	0.030
regulation of retina development in camera type eye	GO:1902866	3	0.030
synapse organization	GO:0050808	125	0.030
positive regulation of cell adhesion	GO:0045785	80	0.030
cell proliferation involved in heart valve development	GO:2000793	2	0.029
positive regulation of growth	GO:0045927	104	0.029
granulocyte macrophage colony stimulating factor production	GO:0032604	3	0.029	Mouse
regulation of hydrolase activity	GO:0051336	246	0.029
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.029
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.029
odontogenesis of dentin containing tooth	GO:0042475	66	0.029	Mouse
mammary gland epithelium development	GO:0061180	65	0.029
glandular epithelial cell differentiation	GO:0002067	38	0.029
defense response to other organism	GO:0098542	197	0.029
response to oxygen levels	GO:0070482	62	0.029
cardiac atrium development	GO:0003230	24	0.029	Mouse
multi organism behavior	GO:0051705	62	0.028
interleukin 6 production	GO:0032635	58	0.028	Mouse
epithelial cell proliferation	GO:0050673	174	0.028
cell proliferation in forebrain	GO:0021846	30	0.028	Mouse
epithelial cell differentiation involved in kidney development	GO:0035850	23	0.028	Mouse
male gamete generation	GO:0048232	285	0.028
regulation of chromosome organization	GO:0033044	83	0.028
cation transport	GO:0006812	399	0.028
columnar cuboidal epithelial cell differentiation	GO:0002065	82	0.028
neuroblast proliferation	GO:0007405	49	0.028
respiratory gaseous exchange	GO:0007585	43	0.028
negative regulation of cellular amine metabolic process	GO:0033239	1	0.028
gliogenesis	GO:0042063	141	0.028
cardiac cell fate determination	GO:0060913	2	0.028	Mouse
myoblast differentiation	GO:0045445	52	0.028	Mouse
cerebellar purkinje cell layer formation	GO:0021694	13	0.027	Mouse
epithelial cell maturation involved in prostate gland development	GO:0060743	4	0.027
multi multicellular organism process	GO:0044706	109	0.027
regulation of striated muscle cell differentiation	GO:0051153	81	0.027
multicellular organismal homeostasis	GO:0048871	164	0.027	Fly
nucleotide catabolic process	GO:0009166	217	0.027
vestibulocochlear nerve development	GO:0021562	7	0.027
regulation of ion transport	GO:0043269	215	0.027
response to extracellular stimulus	GO:0009991	127	0.027
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification	GO:0021913	4	0.027
mapk cascade	GO:0000165	281	0.027
regulation of binding	GO:0051098	111	0.027	Mouse
regulation of intracellular transport	GO:0032386	159	0.027
embryonic heart tube morphogenesis	GO:0003143	51	0.027
cardiac right ventricle formation	GO:0003219	3	0.027
hematopoietic stem cell differentiation	GO:0060218	8	0.027
nucleoside metabolic process	GO:0009116	246	0.026
his purkinje system cell differentiation	GO:0060932	2	0.026
regulation of chromatin organization	GO:1902275	57	0.026
cerebellum morphogenesis	GO:0021587	42	0.026	Mouse
sympathetic nervous system development	GO:0048485	22	0.026
cell type specific apoptotic process	GO:0097285	268	0.026	Mouse
regulation of neural retina development	GO:0061074	3	0.026

Isl2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.094
nervous system disease	DOID:863	0.094
sensory system disease	DOID:0050155	0.079
eye and adnexa disease	DOID:1492	0.079
eye disease	DOID:5614	0.052
retinal disease	DOID:5679	0.044
retinal degeneration	DOID:8466	0.044

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