IMP: Integrative Multi-species Prediction

Mus musculus

250 known processes

Trp73

transformation related protein 73

(Aliases: p73,Tp73)

Entrez: 22062
Ensembl: ENSMUSG00000029026
UniProtKB: Z4YK94
UniProtKB: Q9JJP2
UniProtKB: Q9D6A3

Process Predictions
Disease Predictions

Trp73 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular response to gamma radiation	GO:0071480	4	0.996	Fly
negative regulation of dna replication	GO:0008156	4	0.898	Mouse
urinary bladder development	GO:0060157	5	0.889	Mouse
microtubule cytoskeleton organization	GO:0000226	157	0.820
regulation of cellular catabolic process	GO:0031329	242	0.809	Mouse Fly
dna metabolic process	GO:0006259	303	0.795	Mouse Fly
cell fate commitment	GO:0045165	210	0.742	Mouse
positive regulation of cardiac muscle cell apoptotic process	GO:0010666	3	0.740	Mouse
regulation of cellular amine metabolic process	GO:0033238	20	0.738
positive regulation of cellular catabolic process	GO:0031331	148	0.718	Fly
leukocyte proliferation	GO:0070661	172	0.701	Mouse
regulation of protein kinase activity	GO:0045859	232	0.687
cerebrospinal fluid secretion	GO:0033326	4	0.654
leukocyte differentiation	GO:0002521	342	0.637	Mouse
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	26	0.618	Mouse
modification dependent macromolecule catabolic process	GO:0043632	133	0.617
female genitalia morphogenesis	GO:0048807	3	0.587	Mouse
regulation of mitotic cell cycle phase transition	GO:1901990	73	0.575	Mouse
cellular response to dna damage stimulus	GO:0006974	207	0.572
gland development	GO:0048732	330	0.568	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.565
signal transduction involved in dna damage checkpoint	GO:0072422	3	0.559	Mouse
divalent metal ion transport	GO:0070838	172	0.546
myoblast differentiation involved in skeletal muscle regeneration	GO:0014835	3	0.546
response to hypoxia	GO:0001666	58	0.536	Worm
cellular response to radiation	GO:0071478	28	0.535	Mouse Fly
positive regulation of cell death	GO:0010942	224	0.531
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.531
positive regulation of thymocyte apoptotic process	GO:0070245	5	0.528	Mouse
positive regulation of endopeptidase activity	GO:0010950	43	0.518	Fly
limb development	GO:0060173	166	0.515	Mouse
positive regulation of insulin like growth factor receptor signaling pathway	GO:0043568	8	0.508	Fly
protein processing	GO:0016485	163	0.494	Mouse Fly
stem cell maintenance	GO:0019827	130	0.492
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest	GO:0006977	3	0.479	Mouse
protein modification by small protein conjugation	GO:0032446	187	0.477
microtubule based process	GO:0007017	236	0.476
regulation of multi organism process	GO:0043900	111	0.475
regulation of body fluid levels	GO:0050878	162	0.472
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.472
forebrain development	GO:0030900	302	0.471
axonogenesis	GO:0007409	274	0.465
cellular amine metabolic process	GO:0044106	44	0.464
regulation of peptidase activity	GO:0052547	96	0.463	Mouse Fly
mitochondrial dna repair	GO:0043504	3	0.461	Mouse
signal transduction by p53 class mediator	GO:0072331	51	0.455
negative regulation of cellular catabolic process	GO:0031330	47	0.453	Mouse
intracellular signal transduction involved in g1 dna damage checkpoint	GO:1902400	3	0.452	Mouse
negative regulation of protein metabolic process	GO:0051248	282	0.451
negative regulation of protein maturation	GO:1903318	79	0.448	Mouse
signal transduction involved in mitotic dna damage checkpoint	GO:1902402	3	0.443	Mouse
negative regulation of macroautophagy	GO:0016242	5	0.442	Mouse
lymphocyte apoptotic process	GO:0070227	54	0.436	Mouse
t cell proliferation involved in immune response	GO:0002309	4	0.435	Mouse
positive regulation of leukocyte apoptotic process	GO:2000108	21	0.424	Mouse
cell aging	GO:0007569	35	0.423	Mouse
negative regulation of cellular protein catabolic process	GO:1903363	22	0.423
transmembrane transport	GO:0055085	412	0.415
b cell differentiation	GO:0030183	78	0.412	Mouse
positive regulation of peptidase activity	GO:0010952	49	0.397	Fly
apoptotic signaling pathway	GO:0097190	306	0.394
response to radiation	GO:0009314	165	0.392	Mouse Fly
positive regulation of hydrolase activity	GO:0051345	148	0.385	Fly
t cell differentiation	GO:0030217	174	0.381	Mouse
positive regulation of lymphocyte apoptotic process	GO:0070230	13	0.381	Mouse
positive regulation of proteolysis	GO:0045862	85	0.372	Fly
positive regulation of interleukin 8 secretion	GO:2000484	1	0.366
morphogenesis of a polarized epithelium	GO:0001738	37	0.364	Mouse
hematopoietic progenitor cell differentiation	GO:0002244	143	0.362
thymocyte apoptotic process	GO:0070242	19	0.362	Mouse
dendrite development	GO:0016358	115	0.360
regulation of chromosome organization	GO:0033044	83	0.354	Mouse
regulation of endopeptidase activity	GO:0052548	89	0.352	Mouse Fly
anion transport	GO:0006820	177	0.349
regulation of hydrolase activity	GO:0051336	246	0.346	Mouse Fly
regulation of protein localization	GO:0032880	231	0.344	Fly
negative regulation of growth	GO:0045926	99	0.341	Human
cell cycle arrest	GO:0007050	37	0.339
rrna transcription	GO:0009303	9	0.339	Mouse
regulation of stress activated mapk cascade	GO:0032872	69	0.331
response to ionizing radiation	GO:0010212	42	0.327	Mouse Fly
hippocampus development	GO:0021766	52	0.322
stem cell differentiation	GO:0048863	268	0.319	Fly
protein modification by small protein conjugation or removal	GO:0070647	207	0.313
lymphocyte proliferation	GO:0046651	164	0.312	Mouse
protein maturation	GO:0051604	176	0.310	Mouse Fly
regulation of epidermal cell division	GO:0010482	3	0.309	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.308
embryonic organ morphogenesis	GO:0048562	276	0.307	Zebrafish
positive regulation of cell cycle phase transition	GO:1901989	17	0.306
gliogenesis	GO:0042063	141	0.306
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.305
meiotic cell cycle	GO:0051321	122	0.303	Worm Fly
positive regulation of striated muscle cell apoptotic process	GO:0010663	3	0.295	Mouse
sensory perception	GO:0007600	245	0.295
positive regulation of apoptotic process	GO:0043065	217	0.294
oxygen homeostasis	GO:0032364	2	0.291
negative regulation of leukocyte differentiation	GO:1902106	51	0.291
canonical wnt signaling pathway involved in regulation of type b pancreatic cell proliferation	GO:0044343	1	0.290
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.289
negative regulation of fat cell differentiation	GO:0045599	36	0.288
axis elongation involved in somitogenesis	GO:0090245	4	0.287
ubiquitin dependent protein catabolic process	GO:0006511	129	0.286
photoreceptor cell differentiation	GO:0046530	52	0.284	Fly
peptide metabolic process	GO:0006518	46	0.282
cell cycle checkpoint	GO:0000075	47	0.281	Mouse
wnt signaling pathway involved in forebrain neuroblast division	GO:0021874	2	0.278
glial cell differentiation	GO:0010001	131	0.274
peptidyl tyrosine modification	GO:0018212	145	0.274	Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.272	Mouse Fly
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.272	Fly
mitochondrion degradation	GO:0000422	3	0.268	Mouse
response to oxygen levels	GO:0070482	62	0.264	Worm
nuclear division	GO:0000280	158	0.260	Worm Fly
negative regulation of phosphorus metabolic process	GO:0010563	184	0.258
glial cell apoptotic process	GO:0034349	3	0.257
positive regulation of cellular amine metabolic process	GO:0033240	5	0.256
regulation of kinase activity	GO:0043549	249	0.256
regulation of asymmetric cell division	GO:0009786	4	0.255
t cell differentiation in thymus	GO:0033077	77	0.254	Mouse
protein ubiquitination	GO:0016567	171	0.254
negative regulation of kinase activity	GO:0033673	81	0.249
stem cell development	GO:0048864	219	0.248
regulation of protein processing	GO:0070613	96	0.246	Mouse
pallium development	GO:0021543	120	0.243
regulation of stem cell proliferation	GO:0072091	78	0.235	Mouse
metencephalon development	GO:0022037	89	0.232	Mouse
regionalization	GO:0003002	337	0.231	Mouse
inorganic cation transmembrane transport	GO:0098662	207	0.229
maintenance of cell number	GO:0098727	3	0.228
midgut development	GO:0007494	4	0.227
hindbrain development	GO:0030902	128	0.226	Mouse
regulation of protein maturation	GO:1903317	96	0.226	Mouse
negative regulation of keratinocyte differentiation	GO:0045617	4	0.224	Mouse
regulation of transferase activity	GO:0051338	263	0.221
small gtpase mediated signal transduction	GO:0007264	97	0.221
kidney development	GO:0001822	213	0.221
regulation of neuron differentiation	GO:0045664	281	0.220	Fly
ion transmembrane transport	GO:0034220	361	0.220
negative regulation of phosphatidylinositol 3 kinase activity	GO:0043553	1	0.219	Fly
stress activated protein kinase signaling cascade	GO:0031098	81	0.218
negative regulation of jun kinase activity	GO:0043508	9	0.218
multicellular organism growth	GO:0035264	161	0.217	Mouse Fly
cell fate specification	GO:0001708	72	0.217
proteasomal protein catabolic process	GO:0010498	98	0.217
embryonic skeletal system morphogenesis	GO:0048704	91	0.217	Zebrafish
skeletal system morphogenesis	GO:0048705	203	0.216	Zebrafish
regulation of cellular amino acid metabolic process	GO:0006521	5	0.216
regulation of binding	GO:0051098	111	0.213
segmentation	GO:0035282	93	0.213	Mouse
regulation of proteolysis	GO:0030162	164	0.212	Mouse Fly
divalent inorganic cation transport	GO:0072511	178	0.212
regulation of cell cell adhesion mediated by cadherin	GO:2000047	2	0.210
cellular ketone metabolic process	GO:0042180	84	0.209
lung induction	GO:0060492	3	0.208
cellular macromolecule catabolic process	GO:0044265	206	0.206
inner medullary collecting duct development	GO:0072061	2	0.204
modification dependent protein catabolic process	GO:0019941	133	0.204
reciprocal dna recombination	GO:0035825	16	0.204	Fly
regulation of leukocyte proliferation	GO:0070663	121	0.200
t cell apoptotic process	GO:0070231	39	0.199	Mouse
response to oxidative stress	GO:0006979	123	0.198	Mouse Worm
meiotic nuclear division	GO:0007126	115	0.198	Worm Fly
multicellular organismal homeostasis	GO:0048871	164	0.195
regulation of cytoplasmic transport	GO:1903649	112	0.195	Fly
central nervous system neuron development	GO:0021954	67	0.194
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	2	0.193
positive regulation of myeloid cell differentiation	GO:0045639	43	0.192
intrinsic apoptotic signaling pathway	GO:0097193	132	0.191
salivary gland development	GO:0007431	37	0.191
mesonephric duct formation	GO:0072181	2	0.188
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.188
appendage development	GO:0048736	166	0.188	Mouse
regulation of organ growth	GO:0046620	61	0.187	Human Fly
cellular response to acid chemical	GO:0071229	68	0.186
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:2000059	6	0.186
chromatin organization	GO:0006325	206	0.185	Mouse
regulation of interleukin 8 secretion	GO:2000482	2	0.185
positive regulation of antimicrobial peptide production	GO:0002225	1	0.185
negative regulation of lipid kinase activity	GO:0090219	1	0.183	Fly
protein catabolic process	GO:0030163	221	0.182
appendage morphogenesis	GO:0035107	149	0.180	Mouse
regulation of leukocyte apoptotic process	GO:2000106	56	0.178	Mouse
multicellular organismal response to stress	GO:0033555	62	0.176
renal outer medulla development	GO:0072054	2	0.176
regulation of mapk cascade	GO:0043408	248	0.173
regulation of lymphocyte activation	GO:0051249	240	0.173
gas homeostasis	GO:0033483	3	0.172
hindbrain morphogenesis	GO:0021575	46	0.172
negative regulation of proteolysis	GO:0045861	74	0.171	Mouse
cellular response to starvation	GO:0009267	57	0.170	Mouse Fly
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO:1902255	2	0.170
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.169	Mouse
positive regulation of cell aging	GO:0090343	1	0.168	Mouse
neuron death	GO:0070997	154	0.168
regulation of protein targeting	GO:1903533	61	0.167	Fly
stem cell proliferation	GO:0072089	117	0.166	Mouse Fly
regulation of cell activation	GO:0050865	289	0.166
planar cell polarity pathway involved in cardiac right atrium morphogenesis	GO:0061349	2	0.166
protein localization to membrane	GO:0072657	108	0.165
foregut regionalization	GO:0060423	3	0.165
negative regulation of protein modification process	GO:0031400	163	0.164
regulation of chromatin modification	GO:1903308	57	0.164	Mouse
heart morphogenesis	GO:0003007	178	0.163
regulation of protein import into nucleus	GO:0042306	52	0.163	Fly
establishment of tissue polarity	GO:0007164	28	0.163	Mouse
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.162
regulation of cell cycle	GO:0051726	281	0.162
regulation of epidermal cell differentiation	GO:0045604	21	0.162	Mouse
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	1	0.160
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.160
cerebellum development	GO:0021549	77	0.159	Mouse
neurotransmitter secretion	GO:0007269	62	0.158
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	2	0.157
regulation of testosterone biosynthetic process	GO:2000224	2	0.156
cellular protein catabolic process	GO:0044257	155	0.155
cell growth	GO:0016049	130	0.155
leukocyte apoptotic process	GO:0071887	71	0.155	Mouse
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation	GO:2000079	1	0.154
positive regulation of cell development	GO:0010720	237	0.154
regulation of receptor activity	GO:0010469	41	0.154
bmp signaling pathway	GO:0030509	93	0.153
non canonical wnt signaling pathway involved in heart development	GO:0061341	3	0.153
lymphocyte differentiation	GO:0030098	242	0.152	Mouse
regulation of response to dna damage stimulus	GO:2001020	34	0.152
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.151	Mouse
histone modification	GO:0016570	159	0.150	Mouse
renal system development	GO:0072001	225	0.149	Mouse
nucleocytoplasmic transport	GO:0006913	139	0.149	Mouse Fly
renal vesicle induction	GO:0072034	3	0.149
regulation of cytokine production	GO:0001817	266	0.149
embryonic limb morphogenesis	GO:0030326	126	0.149	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.149
negative regulation of molecular function	GO:0044092	258	0.148
negative regulation of fibroblast proliferation	GO:0048147	14	0.148	Mouse
dna replication	GO:0006260	52	0.147	Mouse
activation of cysteine type endopeptidase activity	GO:0097202	27	0.147	Fly
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.147
somite development	GO:0061053	81	0.146	Mouse
regulation of neuron apoptotic process	GO:0043523	122	0.145
detection of external stimulus	GO:0009581	61	0.145
autophagy	GO:0006914	45	0.145	Mouse Fly
regulation of axon extension	GO:0030516	43	0.144
ras protein signal transduction	GO:0007265	77	0.144
regulation of anagen	GO:0051884	1	0.144
cellular response to x ray	GO:0071481	2	0.143	Fly
inflammatory response	GO:0006954	244	0.143
negative regulation of phosphorylation	GO:0042326	166	0.143
reactive oxygen species metabolic process	GO:0072593	84	0.142	Mouse
regulation of lipid metabolic process	GO:0019216	118	0.141	Fly
positive regulation of mesoderm development	GO:2000382	2	0.141
regulation of proteasomal protein catabolic process	GO:0061136	46	0.139
positive regulation of cell motility	GO:2000147	116	0.137
establishment of organ orientation	GO:0048561	1	0.137
positive regulation of actin filament bundle assembly	GO:0032233	11	0.136
palate development	GO:0060021	76	0.135
lateral inhibition	GO:0046331	1	0.134
positive regulation of neuron projection development	GO:0010976	79	0.134
somatic stem cell maintenance	GO:0035019	47	0.133
digestive tract development	GO:0048565	190	0.132
positive regulation of protein modification process	GO:0031401	299	0.132	Mouse
positive regulation of mapk cascade	GO:0043410	170	0.132
regulation of map kinase activity	GO:0043405	120	0.132
mapk cascade	GO:0000165	281	0.132
tertiary branching involved in mammary gland duct morphogenesis	GO:0060748	3	0.131
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902043	13	0.131
signal transduction involved in mitotic dna integrity checkpoint	GO:1902403	3	0.131	Mouse
response to organonitrogen compound	GO:0010243	246	0.131
cellular amide metabolic process	GO:0043603	58	0.131
cellular amino acid metabolic process	GO:0006520	103	0.131
b cell activation	GO:0042113	161	0.129	Mouse
regulation of mitotic cell cycle	GO:0007346	126	0.129	Human Mouse
cellular response to parathyroid hormone stimulus	GO:0071374	2	0.129
camera type eye development	GO:0043010	266	0.128
regulation of leukocyte differentiation	GO:1902105	159	0.127
regulation of b cell activation	GO:0050864	81	0.127
multi multicellular organism process	GO:0044706	109	0.127
positive regulation of macroautophagy	GO:0016239	3	0.126	Fly
regulation of fibroblast growth factor production	GO:0090270	4	0.126
negative regulation of epidermal cell differentiation	GO:0045605	7	0.125	Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	40	0.125
mitotic cell cycle	GO:0000278	195	0.125	Human Mouse
negative regulation of cellular senescence	GO:2000773	3	0.125
water homeostasis	GO:0030104	27	0.124	Mouse
negative regulation of mitotic cell cycle	GO:0045930	58	0.124	Mouse
cellular senescence	GO:0090398	11	0.123
antimicrobial peptide biosynthetic process	GO:0002777	2	0.123
amine metabolic process	GO:0009308	45	0.123
regulation of cell projection organization	GO:0031344	206	0.123
positive regulation of neuron apoptotic process	GO:0043525	25	0.123	Mouse
ribonucleoside catabolic process	GO:0042454	206	0.122
organelle fission	GO:0048285	170	0.121	Worm Fly
multicellular organismal water homeostasis	GO:0050891	23	0.120	Mouse
mammary gland epithelium development	GO:0061180	65	0.119
carboxylic acid transport	GO:0046942	100	0.119
jnk cascade	GO:0007254	72	0.118
positive regulation of leukocyte differentiation	GO:1902107	86	0.118
myeloid cell homeostasis	GO:0002262	114	0.118
regulation of synaptic plasticity	GO:0048167	87	0.118
cellular response to ionizing radiation	GO:0071479	11	0.117	Mouse Fly
nucleoside triphosphate metabolic process	GO:0009141	230	0.116
regulation of neuron projection development	GO:0010975	169	0.116
defense response to other organism	GO:0098542	197	0.115
regulation of antimicrobial humoral response	GO:0002759	3	0.115
ameboidal type cell migration	GO:0001667	128	0.115
regulation of protein serine threonine kinase activity	GO:0071900	157	0.115
neuron projection extension	GO:1990138	64	0.114
cellular response to growth factor stimulus	GO:0071363	197	0.114	Mouse
neuroblast differentiation	GO:0014016	2	0.114	Fly
spermatogenesis	GO:0007283	284	0.114
midbrain hindbrain boundary maturation	GO:0021732	1	0.113
response to extracellular stimulus	GO:0009991	127	0.112	Mouse Worm Fly
regulation of microtubule based process	GO:0032886	52	0.111
organic cyclic compound catabolic process	GO:1901361	295	0.111
synaptic transmission	GO:0007268	329	0.111
epithelial cell proliferation	GO:0050673	174	0.111	Mouse
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.111
nuclear transport	GO:0051169	139	0.110	Mouse Fly
positive regulation of nervous system development	GO:0051962	221	0.110
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.110	Mouse
cellular ion homeostasis	GO:0006873	165	0.110
signal transduction involved in dna integrity checkpoint	GO:0072401	3	0.109	Mouse
interleukin 8 production	GO:0032637	4	0.109
homeostasis of number of cells	GO:0048872	210	0.109
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.108	Mouse
canonical wnt signaling pathway involved in negative regulation of apoptotic process	GO:0044336	4	0.108
skin development	GO:0043588	220	0.107	Mouse
negative regulation of protein processing	GO:0010955	79	0.107	Mouse
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	56	0.107
positive regulation of mesenchymal cell proliferation	GO:0002053	33	0.106	Mouse
formation of radial glial scaffolds	GO:0021943	4	0.105
chromatin modification	GO:0016568	187	0.105	Mouse
regulation of thymocyte apoptotic process	GO:0070243	14	0.105	Mouse
regulation of epidermis development	GO:0045682	33	0.105	Mouse
wnt signaling pathway	GO:0016055	188	0.105
immune response activating signal transduction	GO:0002757	116	0.104
mitotic g1 dna damage checkpoint	GO:0031571	4	0.104	Mouse
peptidyl tyrosine phosphorylation	GO:0018108	143	0.104	Mouse
negative regulation of proteolysis involved in cellular protein catabolic process	GO:1903051	22	0.104
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.103	Mouse
regulation of b cell proliferation	GO:0030888	39	0.102
negative regulation of transferase activity	GO:0051348	85	0.102
central nervous system morphogenesis	GO:0021551	2	0.102
negative regulation of bmp signaling pathway	GO:0030514	35	0.102
outer medullary collecting duct development	GO:0072060	1	0.101
cellular response to external stimulus	GO:0071496	88	0.101	Mouse Fly
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.101	Fly
regulation of protein catabolic process	GO:0042176	108	0.101
response to pain	GO:0048265	26	0.100
morphogenesis of embryonic epithelium	GO:0016331	159	0.100	Mouse
fertilization	GO:0009566	127	0.100
hypophysis morphogenesis	GO:0048850	3	0.100
negative regulation of cell proliferation	GO:0008285	296	0.100	Human Mouse
muscle fiber development	GO:0048747	76	0.100
organic acid transport	GO:0015849	101	0.099
signal transduction involved in mitotic cell cycle checkpoint	GO:0072413	3	0.099	Mouse
cell division	GO:0051301	120	0.099	Mouse
methylation	GO:0032259	134	0.099
regulation of cell cycle process	GO:0010564	160	0.099	Mouse
lateral sprouting involved in mammary gland duct morphogenesis	GO:0060599	2	0.099
positive regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation	GO:2000081	1	0.098
mitochondrial membrane organization	GO:0007006	26	0.097	Mouse
mitotic nuclear division	GO:0007067	48	0.097
positive regulation of transforming growth factor beta2 production	GO:0032915	2	0.096
b cell proliferation	GO:0042100	53	0.095
positive regulation of organelle organization	GO:0010638	128	0.095	Mouse
regulation of cell growth	GO:0001558	91	0.094
regulation of protein transport	GO:0051223	163	0.094	Fly
neuroblast proliferation	GO:0007405	49	0.094	Mouse Fly
fibroblast proliferation	GO:0048144	35	0.093	Mouse
regulation of cardioblast differentiation	GO:0051890	3	0.093
positive regulation of protein phosphorylation	GO:0001934	242	0.093	Mouse
negative regulation of epithelial cell proliferation	GO:0050680	64	0.093
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.093
midbrain hindbrain boundary maturation during brain development	GO:0022004	1	0.092
spemann organizer formation at the anterior end of the primitive streak	GO:0060064	1	0.092
cytokine production	GO:0001816	319	0.091
response to drug	GO:0042493	75	0.091	Mouse
regulation of reproductive process	GO:2000241	66	0.091
fibroblast growth factor production	GO:0090269	4	0.091
single fertilization	GO:0007338	82	0.090
regulation of ras protein signal transduction	GO:0046578	114	0.089
regulation of jnk cascade	GO:0046328	62	0.089
inorganic ion transmembrane transport	GO:0098660	234	0.089
necrotic cell death	GO:0070265	30	0.088	Mouse
positive regulation of transferase activity	GO:0051347	167	0.088
dna damage checkpoint	GO:0000077	26	0.088	Mouse
negative regulation of cell cycle	GO:0045786	123	0.087
androgen biosynthetic process	GO:0006702	4	0.086
positive regulation of cell cycle	GO:0045787	92	0.086	Mouse Fly
oxidation reduction process	GO:0055114	342	0.085
male gamete generation	GO:0048232	285	0.085
sensory organ morphogenesis	GO:0090596	242	0.085
positive regulation of cell cycle g1 s phase transition	GO:1902808	9	0.085
morphogenesis of an epithelial sheet	GO:0002011	27	0.085
regulation of protein tyrosine kinase activity	GO:0061097	17	0.085
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	34	0.084
myeloid cell differentiation	GO:0030099	233	0.084
negative regulation of stem cell proliferation	GO:2000647	12	0.084	Mouse
skeletal muscle organ development	GO:0060538	163	0.084
organic anion transport	GO:0015711	137	0.084
regulation of lymphocyte proliferation	GO:0050670	117	0.084
nephron epithelium development	GO:0072009	92	0.084
positive regulation of protein kinase activity	GO:0045860	144	0.084
cytoplasmic transport	GO:0016482	234	0.084	Mouse Fly
developmental cell growth	GO:0048588	84	0.084
macromolecule catabolic process	GO:0009057	281	0.083
establishment of endothelial blood brain barrier	GO:0014045	3	0.083
epithelial tube formation	GO:0072175	130	0.083
neural precursor cell proliferation	GO:0061351	121	0.083	Mouse Fly
mitotic cell cycle checkpoint	GO:0007093	31	0.083	Mouse
positive regulation of t cell apoptotic process	GO:0070234	8	0.083	Mouse
dna templated transcriptional preinitiation complex assembly	GO:0070897	4	0.082
cardiac right atrium morphogenesis	GO:0003213	3	0.082
g1 s transition of mitotic cell cycle	GO:0000082	57	0.082	Mouse
testosterone biosynthetic process	GO:0061370	2	0.082
somitogenesis	GO:0001756	69	0.082	Mouse
negative regulation of endopeptidase activity	GO:0010951	44	0.082
peptidyl amino acid modification	GO:0018193	336	0.081	Mouse
positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	25	0.081
lung field specification	GO:0060424	3	0.081
muscle cell differentiation	GO:0042692	261	0.080
spemann organizer formation	GO:0060061	2	0.080
regulation of cell division	GO:0051302	76	0.080	Mouse
response to gamma radiation	GO:0010332	22	0.080	Mouse Fly
placenta development	GO:0001890	140	0.079
macroautophagy	GO:0016236	21	0.079	Mouse Fly
cervix development	GO:0060067	2	0.079
gtp catabolic process	GO:0006184	143	0.079
ossification	GO:0001503	216	0.079
organ growth	GO:0035265	117	0.078	Human Fly
regulation of protein deacetylation	GO:0090311	17	0.078	Mouse
cardiac cell fate specification	GO:0060912	2	0.078
regulation of cardiac cell fate specification	GO:2000043	1	0.078
t cell activation	GO:0042110	289	0.078	Mouse
establishment or maintenance of cell polarity	GO:0007163	86	0.077
digestive system development	GO:0055123	200	0.077
neuronal stem cell division	GO:0036445	10	0.077
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	35	0.077
t cell proliferation	GO:0042098	120	0.077	Mouse
membrane organization	GO:0061024	245	0.076	Mouse
positive regulation of lymphocyte activation	GO:0051251	140	0.076
positive regulation of anagen	GO:0051885	1	0.076
protein localization to organelle	GO:0033365	185	0.076	Mouse Fly
negative regulation of neuron death	GO:1901215	98	0.075
motor neuron migration	GO:0097475	4	0.075
regulation of gliogenesis	GO:0014013	50	0.075
uterus morphogenesis	GO:0061038	2	0.075
negative regulation of neuron differentiation	GO:0045665	101	0.075	Fly
negative regulation of mapk cascade	GO:0043409	65	0.075
positive regulation of cell cell adhesion mediated by cadherin	GO:2000049	2	0.075
organonitrogen compound catabolic process	GO:1901565	264	0.074
calcium ion transmembrane transport	GO:0070588	85	0.074
purine nucleoside catabolic process	GO:0006152	205	0.074
cellular response to nutrient levels	GO:0031669	64	0.074	Mouse Fly
glycosyl compound catabolic process	GO:1901658	206	0.074
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	GO:0061350	2	0.074
positive regulation of jnk cascade	GO:0046330	46	0.073
purine ribonucleotide metabolic process	GO:0009150	290	0.073
keratinocyte differentiation	GO:0030216	48	0.073	Mouse
cerebellar cortex development	GO:0021695	48	0.073
metanephros development	GO:0001656	79	0.073
purine containing compound metabolic process	GO:0072521	311	0.072
cellular response to lipid	GO:0071396	145	0.072
ribonucleotide metabolic process	GO:0009259	291	0.072
positive regulation of cell cycle process	GO:0090068	61	0.072	Mouse
central nervous system neuron differentiation	GO:0021953	162	0.072
response to organic cyclic compound	GO:0014070	198	0.072
negative regulation of protein serine threonine kinase activity	GO:0071901	49	0.072
positive regulation of rho gtpase activity	GO:0032321	41	0.072
regulation of mitochondrial membrane permeability involved in apoptotic process	GO:1902108	14	0.072	Mouse
positive regulation of nucleoside metabolic process	GO:0045979	91	0.072
developmental growth involved in morphogenesis	GO:0060560	138	0.071
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.070	Fly
positive regulation of osteoblast differentiation	GO:0045669	34	0.070
cation homeostasis	GO:0055080	212	0.070
urogenital system development	GO:0001655	261	0.070	Mouse
response to acid chemical	GO:0001101	111	0.070
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration	GO:0014834	3	0.070
cation transmembrane transport	GO:0098655	266	0.069
response to starvation	GO:0042594	65	0.069	Mouse Worm Fly
positive regulation of nucleotide metabolic process	GO:0045981	114	0.069
negative regulation of map kinase activity	GO:0043407	34	0.069
cerebellar cortex morphogenesis	GO:0021696	32	0.069
mitotic cell cycle process	GO:1903047	159	0.068	Mouse
positive regulation of cell migration	GO:0030335	109	0.068
regulation of transforming growth factor beta2 production	GO:0032909	2	0.068
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902042	11	0.068
response to uv	GO:0009411	44	0.068	Mouse Fly
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	27	0.068	Fly

Trp73 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.353
cancer	DOID:162	0.229
organ system cancer	DOID:0050686	0.142
disease of anatomical entity	DOID:7	0.133
integumentary system disease	DOID:16	0.133

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