Mus musculus

44 known processes

Alox5

arachidonate 5-lipoxygenase

(Aliases: 5LX,5-LO,AI850497,5LO,F730011J02,5-LOX)

Alox5 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
leukotriene production involved in inflammatory responseGO:000254020.941
fatty acid derivative biosynthetic processGO:1901570150.931
arachidonic acid metabolite production involved in inflammatory responseGO:000253820.888
fatty acid biosynthetic processGO:0006633410.871
unsaturated fatty acid metabolic processGO:0033559310.831
store operated calcium entryGO:000211570.814
organic acid biosynthetic processGO:0016053860.770
leukotriene biosynthetic processGO:001937050.660
icosanoid metabolic processGO:0006690330.647
unsaturated fatty acid biosynthetic processGO:0006636150.639
cellular lipid metabolic processGO:00442553230.539
monocarboxylic acid metabolic processGO:00327871910.496
lipid biosynthetic processGO:00086101790.452
fatty acid derivative metabolic processGO:1901568330.376
monocarboxylic acid biosynthetic processGO:0072330610.361
fatty acid metabolic processGO:00066311210.342
inflammatory responseGO:00069542440.323
protein homotrimerizationGO:007020740.299
cellular response to calcium ionGO:0071277140.156
icosanoid biosynthetic processGO:0046456150.149
divalent inorganic cation transportGO:00725111780.134
divalent metal ion transportGO:00708381720.132
immune effector processGO:00022523210.130
calcium ion transportGO:00068161590.119
cellular amino acid metabolic processGO:00065201030.116
cytokine productionGO:00018163190.098
carboxylic acid biosynthetic processGO:0046394860.092
amine metabolic processGO:0009308450.084
cellular ketone metabolic processGO:0042180840.078
regulation of leukocyte mediated immunityGO:00027031040.076
cellular amine metabolic processGO:0044106440.076
regulation of cell motilityGO:20001452360.069
leukocyte differentiationGO:00025213420.067
regulation of cell activationGO:00508652890.065
Mouse
cellular response to inorganic substanceGO:0071241370.063
response to calcium ionGO:0051592200.063
response to metal ionGO:0010038470.063
regulation of mapk cascadeGO:00434082480.055
protein oligomerizationGO:0051259670.053
response to inorganic substanceGO:0010035960.053
negative regulation of immune system processGO:00026832090.051
Mouse
leukocyte mediated immunityGO:00024431740.050
regulation of leukocyte differentiationGO:19021051590.050
membrane organizationGO:00610242450.050
Mouse
regulation of cellular ketone metabolic processGO:0010565660.049
regulation of cellular amine metabolic processGO:0033238200.048
regulation of cytokine productionGO:00018172660.047
regulation of cellular amino acid metabolic processGO:000652150.047
regulation of response to woundingGO:19030341890.046
Mouse
regulation of secretionGO:00510462740.046
chemotaxisGO:00069352470.044
regulation of calcium ion transportGO:0051924690.043
heterocycle catabolic processGO:00467002800.043
hematopoietic progenitor cell differentiationGO:00022441430.041
regulation of defense responseGO:00313472330.041
positive regulation of calcium ion transportGO:0051928270.041
cellular response to metal ionGO:0071248310.040
cation transportGO:00068123990.040
regulation of map kinase activityGO:00434051200.039
lymphocyte mediated immunityGO:00024491390.039
protein trimerizationGO:0070206130.038
aromatic compound catabolic processGO:00194392860.038
defense response to other organismGO:00985421970.038
positive regulation of cytokine productionGO:00018191740.037
positive regulation of immune effector processGO:00026991070.037
regulation of organelle organizationGO:00330432890.036
Mouse
transmembrane transportGO:00550854120.036
positive regulation of protein modification processGO:00314012990.035
cell chemotaxisGO:0060326810.035
g protein coupled receptor signaling pathwayGO:00071862430.035
mapk cascadeGO:00001652810.034
ribonucleoside metabolic processGO:00091192450.034
lymphocyte differentiationGO:00300982420.033
wound healingGO:00420601570.033
Mouse
leukocyte migrationGO:00509001240.032
ras protein signal transductionGO:0007265770.032
striated muscle tissue developmentGO:00147062930.032
regulation of establishment of protein localizationGO:00702011810.032
positive regulation of cellular amino acid metabolic processGO:004576430.032
production of molecular mediator of immune responseGO:00024401030.031
positive regulation of transferase activityGO:00513471670.030
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.030
ion transmembrane transportGO:00342203610.030
positive regulation of protein phosphorylationGO:00019342420.030
ribonucleotide metabolic processGO:00092592910.030
regulation of vesicle mediated transportGO:00606271390.029
Mouse
ribonucleoside triphosphate metabolic processGO:00091992200.029
organic cyclic compound catabolic processGO:19013612950.029
gland developmentGO:00487323300.029
cytokine secretionGO:0050663720.029
negative regulation of cellular component organizationGO:00511291940.029
regulation of neuron differentiationGO:00456642810.029
leukocyte activation involved in immune responseGO:00023661260.028
peptidyl amino acid modificationGO:00181933360.028
ameboidal type cell migrationGO:00016671280.028
nucleobase containing small molecule metabolic processGO:00550863520.028
nucleoside phosphate catabolic processGO:19012922220.028
digestive system developmentGO:00551232000.028
purine nucleoside metabolic processGO:00422782410.028
regulation of protein kinase activityGO:00458592320.027
purine nucleotide metabolic processGO:00061633020.026
regulation of cell cycleGO:00517262810.026
macromolecule catabolic processGO:00090572810.026
granulocyte migrationGO:0097530430.026
organic hydroxy compound metabolic processGO:19016152030.026
Mouse
regulation of t cell activationGO:00508631700.025
cation homeostasisGO:00550802120.025
positive regulation of hydrolase activityGO:00513451480.025
positive regulation of leukocyte mediated immunityGO:0002705700.025
regulation of lymphocyte differentiationGO:00456191070.025
positive regulation of apoptotic processGO:00430652170.025
multicellular organismal homeostasisGO:00488711640.025
nucleoside catabolic processGO:00091642060.025
positive regulation of leukocyte differentiationGO:1902107860.025
prostaglandin metabolic processGO:0006693110.025
anatomical structure homeostasisGO:00602491450.025
protein ubiquitinationGO:00165671710.025
regulation of protein serine threonine kinase activityGO:00719001570.025
regulation of anatomical structure sizeGO:00900661780.024
Mouse Rat
sensory perceptionGO:00076002450.024
Rat
cytoplasmic transportGO:00164822340.024
purine ribonucleoside triphosphate catabolic processGO:00092071990.024
negative regulation of phagocytosisGO:005076540.024
purine nucleotide catabolic processGO:00061952110.024
ribonucleoside triphosphate catabolic processGO:00092031990.024
purine containing compound metabolic processGO:00725213110.024
protein modification by small protein conjugation or removalGO:00706472070.024
metal ion homeostasisGO:00550651890.024
muscle tissue developmentGO:00605373080.024
cellular homeostasisGO:00197252400.024
positive regulation of cellular amine metabolic processGO:003324050.024
cellular response to biotic stimulusGO:0071216920.023
cellular nitrogen compound catabolic processGO:00442702800.023
cation transmembrane transportGO:00986552660.023
regulation of muscle tissue developmentGO:1901861970.023
positive regulation of protein serine threonine kinase activityGO:00719021060.023
regulation of cell projection organizationGO:00313442060.022
cellular response to organonitrogen compoundGO:00714171450.022
exocytosisGO:00068871210.022
negative regulation of cellular amino acid metabolic processGO:004576300.022
ribonucleoside catabolic processGO:00424542060.022
angiogenesisGO:00015252010.022
myeloid cell differentiationGO:00300992330.022
organonitrogen compound catabolic processGO:19015652640.022
fertilizationGO:00095661270.022
homeostasis of number of cellsGO:00488722100.021
negative regulation of intracellular signal transductionGO:19025321670.021
tumor necrosis factor superfamily cytokine productionGO:0071706510.021
glycosyl compound catabolic processGO:19016582060.021
muscle cell developmentGO:00550011330.021
regulation of nucleotide catabolic processGO:00308111220.021
erk1 and erk2 cascadeGO:0070371770.021
protein catabolic processGO:00301632210.021
positive regulation of programmed cell deathGO:00430682180.021
nucleoside metabolic processGO:00091162460.021
negative regulation of cellular amine metabolic processGO:003323910.021
negative regulation of cell activationGO:00508661110.021
Mouse
second messenger mediated signalingGO:0019932730.021
nucleoside phosphate metabolic processGO:00067533380.021
positive regulation of protein secretionGO:0050714520.021
response to growth factorGO:00708481980.021
organonitrogen compound biosynthetic processGO:19015661920.021
Mouse
phospholipid metabolic processGO:0006644870.021
Mouse
interleukin 8 productionGO:003263740.021
positive regulation of cellular catabolic processGO:00313311480.020
protein modification by small protein conjugationGO:00324461870.020
coagulationGO:0050817780.020
Mouse
organophosphate catabolic processGO:00464342320.020
nucleotide metabolic processGO:00091173320.020
inorganic ion transmembrane transportGO:00986602340.020
carbohydrate derivative catabolic processGO:19011362310.020
t cell activationGO:00421102890.020
purine ribonucleotide metabolic processGO:00091502900.020
cellular macromolecule catabolic processGO:00442652060.020
cellular response to growth factor stimulusGO:00713631970.020
purine nucleoside triphosphate catabolic processGO:00091462030.019
negative regulation of molecular functionGO:00440922580.019
positive regulation of cell activationGO:00508671580.019
muscle system processGO:00030121410.019
purine ribonucleoside catabolic processGO:00461302050.019
tissue homeostasisGO:00018941150.019
synaptic transmissionGO:00072683290.019
positive regulation of protein kinase activityGO:00458601440.019
single fertilizationGO:0007338820.019
regulation of homeostatic processGO:00328441820.019
peptidyl tyrosine modificationGO:00182121450.019
t cell differentiationGO:00302171740.019
purine ribonucleotide catabolic processGO:00091542080.019
positive regulation of cell deathGO:00109422240.019
alpha beta t cell activationGO:0046631910.019
ribonucleotide catabolic processGO:00092612080.019
negative regulation of protein metabolic processGO:00512482820.019
endocytosisGO:00068971680.019
Mouse
cellular metal ion homeostasisGO:00068751510.019
positive regulation of protein transportGO:0051222930.018
regulation of cytoskeleton organizationGO:00514931220.018
Mouse
regulation of cellular component biogenesisGO:00440871810.018
Mouse
regulation of cellular catabolic processGO:00313292420.018
nucleoside triphosphate metabolic processGO:00091412300.018
actin cytoskeleton organizationGO:00300362200.018
Mouse
cellular divalent inorganic cation homeostasisGO:00725031270.018
anion transportGO:00068201770.018
purine ribonucleoside metabolic processGO:00461282410.018
nucleotide catabolic processGO:00091662170.018
regulation of interleukin 6 productionGO:0032675550.018
nitrogen compound transportGO:00717052710.018
negative regulation of lymphocyte activationGO:0051250910.018
myeloid cell homeostasisGO:00022621140.018
regulation of cytoplasmic transportGO:19036491120.017
blood vessel morphogenesisGO:00485142850.017
regulation of purine nucleotide catabolic processGO:00331211220.017
purine ribonucleoside triphosphate metabolic processGO:00092052200.017
peptidyl tyrosine phosphorylationGO:00181081430.017
regulation of hydrolase activityGO:00513362460.017
gastrulationGO:00073691160.017
camera type eye developmentGO:00430102660.017
cellular protein complex assemblyGO:00436231160.017
Mouse
negative regulation of immune effector processGO:0002698550.017
protein homooligomerizationGO:0051260430.017
regulation of endocytosisGO:0030100690.017
Mouse
small gtpase mediated signal transductionGO:0007264970.017
carbohydrate derivative biosynthetic processGO:19011371830.017
positive regulation of secretionGO:00510471300.017
glycosyl compound metabolic processGO:19016572460.017
striated muscle cell developmentGO:00550021250.017
inorganic cation transmembrane transportGO:00986622070.017
glucose homeostasisGO:00425931280.017
response to lipopolysaccharideGO:00324961280.016
small molecule biosynthetic processGO:00442831320.016
dna metabolic processGO:00062593030.016
cell migration involved in gastrulationGO:0042074130.016
cellular calcium ion homeostasisGO:00068741190.016
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.016
positive regulation of nervous system developmentGO:00519622210.016
nuclear divisionGO:00002801580.016
regulation of engulfment of apoptotic cellGO:190107420.016
Mouse
cellular ion homeostasisGO:00068731650.016
positive regulation of mapk cascadeGO:00434101700.016
regulation of protein transportGO:00512231630.016
positive regulation of kinase activityGO:00336741550.016
positive regulation of erk1 and erk2 cascadeGO:0070374470.016
regulation of t cell proliferationGO:0042129920.016
skeletal system developmentGO:00015013560.016
response to organonitrogen compoundGO:00102432460.016
regulation of interleukin 8 productionGO:003267730.016
organic anion transportGO:00157111370.016
regulation of nucleotide metabolic processGO:00061401690.016
reactive oxygen species metabolic processGO:0072593840.016
intracellular protein transportGO:00068862040.016
regulation of kinase activityGO:00435492490.016
positive regulation of organelle organizationGO:00106381280.016
Mouse
immunoglobulin productionGO:0002377730.015
ribose phosphate metabolic processGO:00196932910.015
skeletal muscle organ developmentGO:00605381630.015
regulation of chemokine productionGO:0032642300.015
urogenital system developmentGO:00016552610.015
regulation of gtp catabolic processGO:00331241130.015
forebrain developmentGO:00309003020.015
organic hydroxy compound transportGO:0015850930.015
endomembrane system organizationGO:00102561470.015
detection of molecule of bacterial originGO:003249020.015
negative regulation of phosphate metabolic processGO:00459361840.015
protein localization to organelleGO:00333651850.015
cellular chemical homeostasisGO:00550822150.015
regulation of body fluid levelsGO:00508781620.015
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.015
regulation of tumor necrosis factor superfamily cytokine productionGO:1903555500.015
positive regulation of gtp catabolic processGO:0033126850.015
myeloid leukocyte mediated immunityGO:0002444420.015
regulation of bindingGO:00510981110.015
regulation of protein localizationGO:00328802310.015
purine containing compound catabolic processGO:00725232130.015
axonogenesisGO:00074092740.015
negative regulation of cell proliferationGO:00082852960.015
regulation of protein bindingGO:0043393600.014
innate immune responseGO:00450871570.014
b cell differentiationGO:0030183780.014
nucleoside triphosphate catabolic processGO:00091432050.014
positive regulation of nucleotide metabolic processGO:00459811140.014
regulation of reactive oxygen species metabolic processGO:2000377400.014
interleukin 6 productionGO:0032635580.014
negative regulation of cytokine productionGO:0001818840.014
cytokine production involved in immune responseGO:0002367340.014
regulation of ras protein signal transductionGO:00465781140.014
regulation of transferase activityGO:00513382630.014
regulation of lymphocyte proliferationGO:00506701170.014
regulation of cellular response to stressGO:00801351590.014
granulocyte chemotaxisGO:0071621390.014
calcium ion homeostasisGO:00550741270.014
regulation of hormone levelsGO:00108172110.014
immune response regulating signaling pathwayGO:00027641250.014
phagocytosisGO:0006909660.014
Mouse
regulation of secretion by cellGO:19035302490.014
regulation of transmembrane transportGO:00347621280.014
digestive tract morphogenesisGO:00485461470.014
purine nucleoside catabolic processGO:00061522050.014
negative regulation of growthGO:0045926990.013
regulation of t cell differentiationGO:0045580830.013
cell activation involved in immune responseGO:00022631260.013
cell type specific apoptotic processGO:00972852680.013
regulation of cellular component sizeGO:00325351210.013
Mouse
regulation of adaptive immune responseGO:0002819900.013
Mouse
regulation of membrane potentialGO:00423911920.013
regulation of nucleoside metabolic processGO:00091181300.013
tissue remodelingGO:00487711020.013
engulfment of apoptotic cellGO:004365230.013
Mouse
negative regulation of phosphorus metabolic processGO:00105631840.013
regulation of ras gtpase activityGO:0032318880.013
positive regulation of nucleotide catabolic processGO:0030813880.013
myeloid leukocyte migrationGO:0097529570.013
myeloid leukocyte differentiationGO:00025731190.013
regulation of apoptotic signaling pathwayGO:20012331970.013
regulation of lymphocyte activationGO:00512492400.013
morphogenesis of a branching epitheliumGO:00611381930.013
glycerophospholipid metabolic processGO:0006650710.013
Mouse
purinergic nucleotide receptor signaling pathwayGO:003559030.013
alpha beta t cell differentiationGO:0046632690.013
activation of immune responseGO:00022531380.013
regulation of cell divisionGO:0051302760.013
positive regulation of tumor necrosis factor productionGO:0032760300.013
regulation of purine nucleotide metabolic processGO:19005421690.013
negative regulation of leukocyte mediated immunityGO:0002704290.013
calcium mediated signalingGO:0019722460.013
cardiac muscle tissue developmentGO:00487381300.013
developmental growth involved in morphogenesisGO:00605601380.012
thrombin receptor signaling pathwayGO:007049320.012
rho protein signal transductionGO:0007266320.012
gtp catabolic processGO:00061841430.012
regulation of chemotaxisGO:0050920530.012
lymphocyte activation involved in immune responseGO:0002285930.012
apoptotic signaling pathwayGO:00971903060.012
regulation of actin filament based processGO:0032970990.012
Mouse
positive regulation of interleukin 8 productionGO:003275720.012
positive regulation of map kinase activityGO:0043406840.012
steroid metabolic processGO:00082021190.012
neutrophil migrationGO:1990266370.012
regulation of proteolysisGO:00301621640.012
negative regulation of protein modification processGO:00314001630.012
negative regulation of cellular protein metabolic processGO:00322692470.012
organelle assemblyGO:00709251770.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.012
regulation of myotube differentiationGO:0010830620.012
adaptive immune responseGO:00022501550.012
Mouse
skeletal system morphogenesisGO:00487052030.012
positive regulation of lymphocyte mediated immunityGO:0002708620.012
regulation of myeloid cell differentiationGO:0045637960.012
sequestering of metal ionGO:0051238190.012
cytokine metabolic processGO:0042107710.012
guanosine containing compound catabolic processGO:19010691440.012
cellular response to molecule of bacterial originGO:0071219830.012
cell divisionGO:00513011200.012
positive regulation of secretion by cellGO:19035321140.012
organelle fissionGO:00482851700.012
regulation of leukocyte proliferationGO:00706631210.012
defense response to virusGO:0051607680.012
regulation of phospholipase c activityGO:190027430.012
b cell activationGO:00421131610.012
positive regulation of cell projection organizationGO:0031346950.012
mitotic cell cycleGO:00002781950.012
cellular response to transforming growth factor beta stimulusGO:0071560880.012
leukocyte chemotaxisGO:0030595690.012
posttranscriptional regulation of gene expressionGO:00106081550.012
interleukin 8 secretionGO:007260630.012
hormone secretionGO:00468791280.012
epithelial tube morphogenesisGO:00605623030.012
regulation of cell substrate adhesionGO:0010810730.012
positive regulation of phagocytosisGO:0050766260.012
neutrophil mediated immunityGO:0002446190.011
regulation of ion transmembrane transportGO:00347651190.011
lateral inhibitionGO:004633110.011
nucleocytoplasmic transportGO:00069131390.011
myeloid leukocyte activationGO:0002274830.011
negative regulation of cell cycleGO:00457861230.011
positive regulation of gtpase activityGO:0043547850.011
neuron deathGO:00709971540.011
regulation of neuron projection developmentGO:00109751690.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.011
microtubule based processGO:00070172360.011
regulation of lymphocyte mediated immunityGO:0002706840.011
positive regulation of lymphocyte differentiationGO:0045621610.011
nuclear transportGO:00511691390.011
protein processingGO:00164851630.011
morphogenesis of a branching structureGO:00017632030.011
mesodermal cell migrationGO:000807840.011
meiotic nuclear divisionGO:00071261150.011
regulation of epithelial cell proliferationGO:00506781410.011
negative regulation of adaptive immune responseGO:0002820250.011
Mouse
regulation of striated muscle cell differentiationGO:0051153810.011
regulation of actin cytoskeleton organizationGO:0032956840.011
Mouse
release of sequestered calcium ion into cytosolGO:0051209420.011
learning or memoryGO:00076111480.011
regulation of lipid metabolic processGO:00192161180.011
protein polymerizationGO:0051258570.011
Mouse
regulation of myeloid leukocyte differentiationGO:0002761580.011
actin filament organizationGO:00070151130.011
Mouse
stem cell differentiationGO:00488632680.011
regulation of multi organism processGO:00439001110.011
regulation of ion transportGO:00432692150.011
carboxylic acid transportGO:00469421000.011
negative regulation of cell developmentGO:00107211690.011
positive regulation of nucleoside metabolic processGO:0045979910.011
negative regulation of lymphocyte proliferationGO:0050672450.011
myosin filament assemblyGO:003103420.011
positive regulation of neuron differentiationGO:00456661410.011
gtp metabolic processGO:00460391440.011
regulation of action potentialGO:009890040.011
stress activated mapk cascadeGO:0051403800.011
interferon gamma productionGO:0032609670.011
mature dendritic cell differentiationGO:009702930.011
neutrophil chemotaxisGO:0030593360.011
positive regulation of purine nucleotide metabolic processGO:19005441140.011
retrograde transport endosome to golgiGO:004214720.010
norepinephrine secretionGO:004824320.010
regulation of angiogenesisGO:0045765810.010
regulation of immunoglobulin productionGO:0002637420.010
tumor necrosis factor productionGO:0032640500.010
t cell mediated immunityGO:0002456500.010
modification dependent protein catabolic processGO:00199411330.010
cellular response to peptidoglycanGO:007122440.010
action potentialGO:0001508780.010
regulation of mast cell activationGO:0033003210.010
negative regulation of nik nf kappab signalingGO:190122320.010
digestive tract developmentGO:00485651900.010
glycoprotein biosynthetic processGO:0009101890.010
response to molecule of bacterial originGO:00022371430.010
carbohydrate metabolic processGO:00059752300.010
negative regulation of secretion by cellGO:1903531540.010
negative regulation of response to woundingGO:1903035770.010
Mouse
response to nutrient levelsGO:00316671090.010
Rat
sensory organ morphogenesisGO:00905962420.010
regulation of erk1 and erk2 cascadeGO:0070372710.010
regulation of neuron deathGO:19012141340.010
cellular response to lipopolysaccharideGO:0071222770.010
negative regulation of homeostatic processGO:0032845710.010
cellular response to lipidGO:00713961450.010
cellular response to nutrient levelsGO:0031669640.010
respiratory tube developmentGO:00303231670.010
hormone metabolic processGO:0042445860.010
guanosine containing compound metabolic processGO:19010681440.010
response to extracellular stimulusGO:00099911270.010
Rat

Alox5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
vascular diseaseDOID:17800.386
cardiovascular system diseaseDOID:128700.386
disease of anatomical entityDOID:700.386
artery diseaseDOID:005082800.316
cerebrovascular diseaseDOID:671300.035
disease of metabolismDOID:001466700.021
immune system diseaseDOID:291400.020
nervous system diseaseDOID:86300.016
hematopoietic system diseaseDOID:7400.016
musculoskeletal system diseaseDOID:1700.016
connective tissue diseaseDOID:6500.016
inherited metabolic disorderDOID:65500.011
disease of cellular proliferationDOID:1456600.011
organ system cancerDOID:005068600.011
cancerDOID:16200.011
central nervous system diseaseDOID:33100.011
sensory system diseaseDOID:005015500.010