IMP: Integrative Multi-species Prediction

Mus musculus

229 known processes

Casp3

caspase 3

(Aliases: Caspase-3,Apopain,CC3,Lice,AC-3,CPP32,mldy,A830040C14Rik,Yama)

Ensembl: ENSMUSG00000031628
Entrez: 12367
UniProtKB: P70677

Process Predictions
Disease Predictions

Casp3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna metabolic process	GO:0006259	303	0.899
apoptotic signaling pathway	GO:0097190	306	0.870
mitochondrion organization	GO:0007005	134	0.726
cellular response to dna damage stimulus	GO:0006974	207	0.634
release of cytochrome c from mitochondria	GO:0001836	23	0.553
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.523	Mouse
macromolecule catabolic process	GO:0009057	281	0.500
regulation of apoptotic signaling pathway	GO:2001233	197	0.481	Mouse
myeloid cell differentiation	GO:0030099	233	0.472	Human Mouse
extrinsic apoptotic signaling pathway	GO:0097191	126	0.425
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.418	Mouse
cellular amino acid metabolic process	GO:0006520	103	0.416
leukocyte differentiation	GO:0002521	342	0.391	Mouse
positive regulation of proteolysis	GO:0045862	85	0.374	Mouse
response to light stimulus	GO:0009416	135	0.347
germ cell development	GO:0007281	185	0.327
regulation of peptidase activity	GO:0052547	96	0.320	Mouse
regulation of cellular catabolic process	GO:0031329	242	0.319
male gamete generation	GO:0048232	285	0.294
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.284
regulation of kinase activity	GO:0043549	249	0.283
cellular response to oxidative stress	GO:0034599	76	0.263
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.263	Mouse
spermatogenesis	GO:0007283	284	0.258
oxidation reduction process	GO:0055114	342	0.258
neuron apoptotic process	GO:0051402	142	0.250
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.248	Mouse
intrinsic apoptotic signaling pathway	GO:0097193	132	0.245
microtubule cytoskeleton organization	GO:0000226	157	0.244
response to radiation	GO:0009314	165	0.234
positive regulation of programmed cell death	GO:0043068	218	0.228
neuron death	GO:0070997	154	0.221
negative regulation of cell proliferation	GO:0008285	296	0.221
regulation of cellular ketone metabolic process	GO:0010565	66	0.214
regulation of proteolysis	GO:0030162	164	0.207	Mouse
regulation of protein kinase activity	GO:0045859	232	0.204
cell type specific apoptotic process	GO:0097285	268	0.202
regulation of cellular amine metabolic process	GO:0033238	20	0.195
response to organic cyclic compound	GO:0014070	198	0.190	Mouse
negative regulation of cell activation	GO:0050866	111	0.189
positive regulation of cellular amine metabolic process	GO:0033240	5	0.189
protein processing	GO:0016485	163	0.189
response to oxidative stress	GO:0006979	123	0.188
positive regulation of protein modification process	GO:0031401	299	0.186
regulation of transferase activity	GO:0051338	263	0.184
regulation of protein localization	GO:0032880	231	0.184	Mouse
protein localization to organelle	GO:0033365	185	0.182
morphogenesis of embryonic epithelium	GO:0016331	159	0.177	Mouse
regulation of hydrolase activity	GO:0051336	246	0.175	Mouse
mitotic cell cycle	GO:0000278	195	0.172
negative regulation of phosphorylation	GO:0042326	166	0.167
regulation of cell cycle	GO:0051726	281	0.164
protein maturation	GO:0051604	176	0.162
response to molecule of bacterial origin	GO:0002237	143	0.161	Mouse
hepatocyte apoptotic process	GO:0097284	11	0.159	Mouse
amine metabolic process	GO:0009308	45	0.158
b cell activation	GO:0042113	161	0.157
myeloid leukocyte differentiation	GO:0002573	119	0.155	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.154
apoptotic mitochondrial changes	GO:0008637	48	0.153
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.151	Mouse
positive regulation of organelle organization	GO:0010638	128	0.150
cellular lipid metabolic process	GO:0044255	323	0.150
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	34	0.147
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.145	Mouse
axonogenesis	GO:0007409	274	0.145
positive regulation of hydrolase activity	GO:0051345	148	0.141	Mouse
regulation of cellular component biogenesis	GO:0044087	181	0.141
inflammatory response	GO:0006954	244	0.138	Mouse
chromatin modification	GO:0016568	187	0.136
positive regulation of cell death	GO:0010942	224	0.136
negative regulation of immune system process	GO:0002683	209	0.135
regulation of cellular amino acid metabolic process	GO:0006521	5	0.134
response to organonitrogen compound	GO:0010243	246	0.134	Mouse
cellular homeostasis	GO:0019725	240	0.133
positive regulation of apoptotic process	GO:0043065	217	0.132
regulation of leukocyte differentiation	GO:1902105	159	0.127
innate immune response	GO:0045087	157	0.125
muscle cell differentiation	GO:0042692	261	0.125
regulation of neuron death	GO:1901214	134	0.124
negative regulation of phosphate metabolic process	GO:0045936	184	0.123
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.123
t cell proliferation	GO:0042098	120	0.122
cellular macromolecule catabolic process	GO:0044265	206	0.122
peptidyl amino acid modification	GO:0018193	336	0.122
regulation of cell activation	GO:0050865	289	0.122
glial cell apoptotic process	GO:0034349	3	0.121
carbohydrate metabolic process	GO:0005975	230	0.120
nucleobase containing small molecule metabolic process	GO:0055086	352	0.119
activation of cysteine type endopeptidase activity	GO:0097202	27	0.117	Mouse
dna repair	GO:0006281	107	0.116
positive regulation of growth	GO:0045927	104	0.115
mitotic cell cycle process	GO:1903047	159	0.115
regulation of myeloid cell differentiation	GO:0045637	96	0.114
regulation of organelle organization	GO:0033043	289	0.113
organonitrogen compound biosynthetic process	GO:1901566	192	0.113
regulation of neuron apoptotic process	GO:0043523	122	0.112
organophosphate biosynthetic process	GO:0090407	122	0.111
maintenance of location	GO:0051235	89	0.108
negative regulation of lymphocyte activation	GO:0051250	91	0.108
microtubule based process	GO:0007017	236	0.108
protein catabolic process	GO:0030163	221	0.107
cellular response to lipid	GO:0071396	145	0.106	Zebrafish Mouse
negative regulation of cell cycle	GO:0045786	123	0.105
leukocyte proliferation	GO:0070661	172	0.105
cellular amine metabolic process	GO:0044106	44	0.104
carbohydrate derivative biosynthetic process	GO:1901137	183	0.104
negative regulation of molecular function	GO:0044092	258	0.103
forebrain development	GO:0030900	302	0.100
digestive tract development	GO:0048565	190	0.099
regulation of cellular response to stress	GO:0080135	159	0.099
erythrocyte differentiation	GO:0030218	88	0.098	Human
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.097
meiotic cell cycle	GO:0051321	122	0.097
regulation of membrane potential	GO:0042391	192	0.097	Mouse
necroptotic process	GO:0070266	21	0.096	Mouse
dna replication	GO:0006260	52	0.096
establishment of protein localization to organelle	GO:0072594	118	0.096
negative regulation of cellular component organization	GO:0051129	194	0.095
muscle tissue development	GO:0060537	308	0.095
positive regulation of endopeptidase activity	GO:0010950	43	0.093	Mouse
regulation of t cell activation	GO:0050863	170	0.092
g protein coupled receptor signaling pathway	GO:0007186	243	0.089
cellular ketone metabolic process	GO:0042180	84	0.089
blood vessel morphogenesis	GO:0048514	285	0.088	Mouse
nucleotide biosynthetic process	GO:0009165	78	0.088
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.088
organic cyclic compound catabolic process	GO:1901361	295	0.087
myeloid cell homeostasis	GO:0002262	114	0.086	Human
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	1	0.086
response to uv	GO:0009411	44	0.086
skeletal muscle organ development	GO:0060538	163	0.085
negative regulation of cellular protein metabolic process	GO:0032269	247	0.085
protein modification by small protein conjugation or removal	GO:0070647	207	0.085
nucleoside phosphate biosynthetic process	GO:1901293	79	0.084
protein targeting	GO:0006605	143	0.084
regulation of endopeptidase activity	GO:0052548	89	0.083	Mouse
regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0000083	3	0.083
spermatid differentiation	GO:0048515	115	0.083
regulation of autophagy	GO:0010506	30	0.082	Mouse
cell fate commitment	GO:0045165	210	0.081
t cell differentiation	GO:0030217	174	0.080
negative regulation of protein phosphorylation	GO:0001933	126	0.080
lymphocyte differentiation	GO:0030098	242	0.080
ubiquitin dependent protein catabolic process	GO:0006511	129	0.079
locomotory behavior	GO:0007626	195	0.079
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.078
epithelial tube morphogenesis	GO:0060562	303	0.077	Mouse
heterocycle catabolic process	GO:0046700	280	0.077
intracellular protein transport	GO:0006886	204	0.076
chemotaxis	GO:0006935	247	0.076
angiogenesis	GO:0001525	201	0.076	Mouse
lipid biosynthetic process	GO:0008610	179	0.076
nucleoside phosphate metabolic process	GO:0006753	338	0.075
regulation of protein complex assembly	GO:0043254	83	0.075
actin cytoskeleton organization	GO:0030036	220	0.075
hematopoietic progenitor cell differentiation	GO:0002244	143	0.075
regulation of execution phase of apoptosis	GO:1900117	9	0.074
cellular response to gamma radiation	GO:0071480	4	0.073
signal transduction by p53 class mediator	GO:0072331	51	0.073
epithelial cell proliferation	GO:0050673	174	0.073
organic anion transport	GO:0015711	137	0.073
neural tube development	GO:0021915	160	0.072	Mouse
purine nucleoside metabolic process	GO:0042278	241	0.072
homeostasis of number of cells	GO:0048872	210	0.072
organic hydroxy compound metabolic process	GO:1901615	203	0.071
t cell activation	GO:0042110	289	0.071
regulation of cell cycle process	GO:0010564	160	0.071
epithelial tube formation	GO:0072175	130	0.070	Mouse
regulation of defense response	GO:0031347	233	0.070	Mouse
positive regulation of protein kinase activity	GO:0045860	144	0.070
regulation of chromosome organization	GO:0033044	83	0.069
i kappab kinase nf kappab signaling	GO:0007249	85	0.069	Mouse
negative regulation of cellular amine metabolic process	GO:0033239	1	0.069
cytoplasmic transport	GO:0016482	234	0.069
regulation of protein serine threonine kinase activity	GO:0071900	157	0.069
regulation of lymphocyte activation	GO:0051249	240	0.069
embryonic epithelial tube formation	GO:0001838	130	0.069	Mouse
striated muscle tissue development	GO:0014706	293	0.068
wnt signaling pathway	GO:0016055	188	0.068
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.068	Mouse
negative regulation of leukocyte differentiation	GO:1902106	51	0.068
positive regulation of protein phosphorylation	GO:0001934	242	0.067
regulation of ion transport	GO:0043269	215	0.067
glycosyl compound metabolic process	GO:1901657	246	0.067
nucleic acid phosphodiester bond hydrolysis	GO:0090305	49	0.067
reactive oxygen species metabolic process	GO:0072593	84	0.066
regulation of mapk cascade	GO:0043408	248	0.066
negative regulation of protein modification process	GO:0031400	163	0.065
monocarboxylic acid metabolic process	GO:0032787	191	0.065
multicellular organism growth	GO:0035264	161	0.065
branching morphogenesis of an epithelial tube	GO:0048754	159	0.065
dna conformation change	GO:0071103	37	0.065
regulation of protein transport	GO:0051223	163	0.064	Mouse
meiotic nuclear division	GO:0007126	115	0.064
cellular response to growth factor stimulus	GO:0071363	197	0.063
cellular response to hormone stimulus	GO:0032870	150	0.063	Mouse
circulatory system process	GO:0003013	197	0.063
regulation of response to wounding	GO:1903034	189	0.063	Mouse
embryonic organ morphogenesis	GO:0048562	276	0.063
rhythmic process	GO:0048511	174	0.063
organelle fission	GO:0048285	170	0.062
regulation of neuron differentiation	GO:0045664	281	0.062
cellular ion homeostasis	GO:0006873	165	0.061
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.061
digestive system development	GO:0055123	200	0.060
protein import into nucleus	GO:0006606	95	0.060
gonad development	GO:0008406	141	0.060
stem cell proliferation	GO:0072089	117	0.060
positive regulation of transferase activity	GO:0051347	167	0.060
regulation of cell migration	GO:0030334	219	0.060
sensory perception	GO:0007600	245	0.060
histone modification	GO:0016570	159	0.059
anion transport	GO:0006820	177	0.059
regulation of t cell proliferation	GO:0042129	92	0.058
hexose metabolic process	GO:0019318	98	0.058
protein ubiquitination	GO:0016567	171	0.058
lung development	GO:0030324	164	0.058
neuron projection guidance	GO:0097485	141	0.058
stem cell differentiation	GO:0048863	268	0.058
female gamete generation	GO:0007292	74	0.058
skeletal system development	GO:0001501	356	0.057
response to lipopolysaccharide	GO:0032496	128	0.057	Mouse
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.056
cation homeostasis	GO:0055080	212	0.056
negative regulation of neuron death	GO:1901215	98	0.056
cell division	GO:0051301	120	0.055
covalent chromatin modification	GO:0016569	163	0.055
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.055
positive regulation of homeostatic process	GO:0032846	64	0.055
negative regulation of necroptotic process	GO:0060546	9	0.055	Mouse
positive regulation of cellular catabolic process	GO:0031331	148	0.054
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	27	0.054	Mouse
anatomical structure homeostasis	GO:0060249	145	0.054
cellular protein complex assembly	GO:0043623	116	0.054
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	16	0.054
negative regulation of protein metabolic process	GO:0051248	282	0.054
positive regulation of cell development	GO:0010720	237	0.054
negative regulation of transferase activity	GO:0051348	85	0.053
signal transduction in absence of ligand	GO:0038034	55	0.053
nucleotide metabolic process	GO:0009117	332	0.053
response to oxygen levels	GO:0070482	62	0.053	Mouse
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.052
intrinsic apoptotic signaling pathway in response to oxidative stress	GO:0008631	19	0.052
actin filament organization	GO:0007015	113	0.052
single organism cell adhesion	GO:0098602	156	0.052
nuclear division	GO:0000280	158	0.052
organonitrogen compound catabolic process	GO:1901565	264	0.052
cellular nitrogen compound catabolic process	GO:0044270	280	0.052
respiratory tube development	GO:0030323	167	0.052
regulation of multi organism process	GO:0043900	111	0.052
cellular response to radiation	GO:0071478	28	0.052
mitochondrial membrane organization	GO:0007006	26	0.052
neural tube formation	GO:0001841	108	0.052	Mouse
regulation of release of cytochrome c from mitochondria	GO:0090199	11	0.051
morphogenesis of a branching structure	GO:0001763	203	0.051
monosaccharide metabolic process	GO:0005996	106	0.051
regulation of establishment of protein localization	GO:0070201	181	0.051	Mouse
methylation	GO:0032259	134	0.050
cellular protein catabolic process	GO:0044257	155	0.050
dephosphorylation	GO:0016311	129	0.049
alpha amino acid metabolic process	GO:1901605	59	0.049
regulation of epithelial cell proliferation	GO:0050678	141	0.049
chromosome segregation	GO:0007059	48	0.049
meiotic cell cycle process	GO:1903046	77	0.049
cellular chemical homeostasis	GO:0055082	215	0.048
negative regulation of phosphorus metabolic process	GO:0010563	184	0.048
response to ionizing radiation	GO:0010212	42	0.048
double strand break repair	GO:0006302	48	0.047
regulation of cell cycle phase transition	GO:1901987	77	0.047
regulation of chromatin modification	GO:1903308	57	0.047
cell adhesion	GO:0007155	329	0.046
programmed necrotic cell death	GO:0097300	28	0.046	Mouse
axon guidance	GO:0007411	141	0.046
positive regulation of kinase activity	GO:0033674	155	0.046
regulation of cytokine production	GO:0001817	266	0.046	Mouse
membrane organization	GO:0061024	245	0.046
nitrogen compound transport	GO:0071705	271	0.046
dna dependent dna replication	GO:0006261	24	0.046
negative regulation of neuron apoptotic process	GO:0043524	92	0.046
ribonucleoside metabolic process	GO:0009119	245	0.046
cellular response to organonitrogen compound	GO:0071417	145	0.046
macrophage differentiation	GO:0030225	20	0.045	Mouse
spermatid development	GO:0007286	108	0.045
positive regulation of myeloid cell differentiation	GO:0045639	43	0.045
interspecies interaction between organisms	GO:0044419	83	0.045
purine ribonucleotide metabolic process	GO:0009150	290	0.045
regulation of cell adhesion	GO:0030155	154	0.045
nucleotide catabolic process	GO:0009166	217	0.045
ribose phosphate metabolic process	GO:0019693	291	0.045
cell cycle g1 s phase transition	GO:0044843	57	0.045
detection of stimulus	GO:0051606	84	0.045
nuclear transport	GO:0051169	139	0.044
negative regulation of dna replication	GO:0008156	4	0.044
mapk cascade	GO:0000165	281	0.044
gland development	GO:0048732	330	0.044
response to oxygen radical	GO:0000305	16	0.044
dendrite development	GO:0016358	115	0.044
cell cycle arrest	GO:0007050	37	0.044
regulation of mitotic cell cycle	GO:0007346	126	0.043
morphogenesis of a branching epithelium	GO:0061138	193	0.043
meiosis i	GO:0007127	60	0.043
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.042
chromatin organization	GO:0006325	206	0.042
response to inorganic substance	GO:0010035	96	0.042
nucleocytoplasmic transport	GO:0006913	139	0.042
regulation of inflammatory response	GO:0050727	147	0.042	Mouse
oocyte construction	GO:0007308	2	0.042
sensory organ morphogenesis	GO:0090596	242	0.042
establishment or maintenance of cytoskeleton polarity	GO:0030952	2	0.042
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.041
response to endoplasmic reticulum stress	GO:0034976	53	0.041	Mouse
regulation of system process	GO:0044057	200	0.041
cellular response to peptide	GO:1901653	92	0.041
regulation of secretion	GO:0051046	274	0.041	Mouse
response to extracellular stimulus	GO:0009991	127	0.041
tube formation	GO:0035148	140	0.041	Mouse
developmental maturation	GO:0021700	193	0.041
dna catabolic process	GO:0006308	19	0.040
small gtpase mediated signal transduction	GO:0007264	97	0.040
negative regulation of transcription involved in g1 s transition of mitotic cell cycle	GO:0071930	1	0.040
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.040
transmembrane transport	GO:0055085	412	0.040
regulation of actin cytoskeleton organization	GO:0032956	84	0.040
sperm individualization	GO:0007291	1	0.040
regulation of anatomical structure size	GO:0090066	178	0.039
metencephalon development	GO:0022037	89	0.039
ion transmembrane transport	GO:0034220	361	0.039
cellular response to external stimulus	GO:0071496	88	0.039
positive regulation of peptidase activity	GO:0010952	49	0.039	Mouse
regulation of secretion by cell	GO:1903530	249	0.038	Mouse
negative regulation of kinase activity	GO:0033673	81	0.038
generation of precursor metabolites and energy	GO:0006091	103	0.038
response to decreased oxygen levels	GO:0036293	59	0.038	Mouse
cellular metal ion homeostasis	GO:0006875	151	0.038
g1 s transition of mitotic cell cycle	GO:0000082	57	0.038
cellular component disassembly involved in execution phase of apoptosis	GO:0006921	9	0.037
purine containing compound metabolic process	GO:0072521	311	0.037
regulation of mitochondrial membrane potential	GO:0051881	17	0.037	Mouse
ribonucleotide metabolic process	GO:0009259	291	0.037
ribonucleotide catabolic process	GO:0009261	208	0.037
negative regulation of growth	GO:0045926	99	0.037
nucleoside triphosphate metabolic process	GO:0009141	230	0.037
cellular amide metabolic process	GO:0043603	58	0.037
segmentation	GO:0035282	93	0.037
regulation of body fluid levels	GO:0050878	162	0.036
negative regulation of t cell activation	GO:0050868	65	0.036
organelle assembly	GO:0070925	177	0.036
lipid catabolic process	GO:0016042	69	0.036
regulation of protein secretion	GO:0050708	82	0.036	Mouse
telencephalon development	GO:0021537	186	0.036
leukocyte apoptotic process	GO:0071887	71	0.036	Mouse
asymmetric stem cell division	GO:0098722	3	0.036
positive regulation of defense response	GO:0031349	124	0.036
regulation of leukocyte proliferation	GO:0070663	121	0.036
purine nucleotide metabolic process	GO:0006163	302	0.036
organelle localization	GO:0051640	179	0.036
phagocytosis	GO:0006909	66	0.036
positive regulation of cytokine production	GO:0001819	174	0.035	Mouse
fatty acid metabolic process	GO:0006631	121	0.035
regulation of cell growth	GO:0001558	91	0.035
protein import	GO:0017038	101	0.035
response to nutrient levels	GO:0031667	109	0.035
b cell differentiation	GO:0030183	78	0.035
protein oligomerization	GO:0051259	67	0.035
heart contraction	GO:0060047	93	0.035
cellularization	GO:0007349	1	0.035
positive regulation of cellular component biogenesis	GO:0044089	94	0.035
membrane depolarization	GO:0051899	64	0.035	Mouse
endocytosis	GO:0006897	168	0.035
camera type eye development	GO:0043010	266	0.035
cytokine production	GO:0001816	319	0.035	Mouse
response to superoxide	GO:0000303	16	0.035
lymphocyte homeostasis	GO:0002260	64	0.035
organic acid transport	GO:0015849	101	0.035
positive regulation of chromatin modification	GO:1903310	28	0.035
zymogen activation	GO:0031638	41	0.034	Mouse
embryonic appendage morphogenesis	GO:0035113	126	0.034
nucleoside phosphate catabolic process	GO:1901292	222	0.034
glycosyl compound catabolic process	GO:1901658	206	0.034
peptidyl tyrosine modification	GO:0018212	145	0.034
cation transport	GO:0006812	399	0.034
wound healing	GO:0042060	157	0.033
negative regulation of b cell activation	GO:0050869	27	0.033
response to acid chemical	GO:0001101	111	0.033	Zebrafish
carbohydrate derivative catabolic process	GO:1901136	231	0.033
modification dependent protein catabolic process	GO:0019941	133	0.033
carboxylic acid transport	GO:0046942	100	0.033
regulation of protein targeting	GO:1903533	61	0.033
digestive tract morphogenesis	GO:0048546	147	0.033
regulation of binding	GO:0051098	111	0.033
lipid homeostasis	GO:0055088	63	0.033
urogenital system development	GO:0001655	261	0.032
mitochondrial transport	GO:0006839	36	0.032
blood circulation	GO:0008015	195	0.032
regulation of lymphocyte apoptotic process	GO:0070228	41	0.032	Mouse
sensory perception of sound	GO:0007605	97	0.032
oogenesis	GO:0048477	56	0.032
immune response regulating signaling pathway	GO:0002764	125	0.032
respiratory system development	GO:0060541	190	0.032
positive regulation of nervous system development	GO:0051962	221	0.031
ras protein signal transduction	GO:0007265	77	0.031
dna catabolic process endonucleolytic	GO:0000737	15	0.031
limb development	GO:0060173	166	0.031
regulation of actin filament based process	GO:0032970	99	0.031
cell growth	GO:0016049	130	0.031
cellular response to light stimulus	GO:0071482	19	0.031
cellular modified amino acid metabolic process	GO:0006575	63	0.031
regulation of lipid metabolic process	GO:0019216	118	0.031
response to growth factor	GO:0070848	198	0.031
renal system development	GO:0072001	225	0.030
regulation of intracellular transport	GO:0032386	159	0.030
metal ion homeostasis	GO:0055065	189	0.030
sensory perception of mechanical stimulus	GO:0050954	107	0.030
response to steroid hormone	GO:0048545	56	0.030	Mouse
immune effector process	GO:0002252	321	0.030
regulation of mitochondrial membrane permeability	GO:0046902	17	0.030
retina development in camera type eye	GO:0060041	119	0.030
oocyte axis specification	GO:0007309	2	0.030
modification dependent macromolecule catabolic process	GO:0043632	133	0.030
single organism nuclear import	GO:1902593	95	0.030
carbohydrate homeostasis	GO:0033500	128	0.030
regulation of homeostatic process	GO:0032844	182	0.030
response to peptide	GO:1901652	136	0.029
striated muscle cell development	GO:0055002	125	0.029
peptidyl tyrosine phosphorylation	GO:0018108	143	0.029
nuclear import	GO:0051170	95	0.029
transmission of nerve impulse	GO:0019226	76	0.029
cellular component assembly involved in morphogenesis	GO:0010927	139	0.029
development of primary sexual characteristics	GO:0045137	143	0.029
stem cell development	GO:0048864	219	0.029
epithelial cell development	GO:0002064	159	0.029
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	88	0.029
small molecule biosynthetic process	GO:0044283	132	0.029
protein methylation	GO:0006479	81	0.029
multi multicellular organism process	GO:0044706	109	0.029
protein modification by small protein conjugation	GO:0032446	187	0.029
aromatic compound catabolic process	GO:0019439	286	0.029
muscle system process	GO:0003012	141	0.029
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.029
regulation of apoptotic dna fragmentation	GO:1902510	5	0.028
connective tissue development	GO:0061448	179	0.028
skeletal system morphogenesis	GO:0048705	203	0.028
regulation of lymphocyte differentiation	GO:0045619	107	0.028
response to reactive oxygen species	GO:0000302	56	0.028
iron ion homeostasis	GO:0055072	36	0.028
glucose metabolic process	GO:0006006	92	0.028
cellular response to steroid hormone stimulus	GO:0071383	33	0.028	Mouse
lipid localization	GO:0010876	126	0.028
purine ribonucleotide catabolic process	GO:0009154	208	0.028
ossification	GO:0001503	216	0.028
positive regulation of neuron differentiation	GO:0045666	141	0.028
oocyte differentiation	GO:0009994	35	0.028
associative learning	GO:0008306	61	0.027
regulation of mitochondrion organization	GO:0010821	27	0.027
pole plasm assembly	GO:0007315	2	0.027
regulation of hormone levels	GO:0010817	211	0.027
dna biosynthetic process	GO:0071897	22	0.027
lateral inhibition	GO:0046331	1	0.027
cellular response to lipopolysaccharide	GO:0071222	77	0.027
cellular response to molecule of bacterial origin	GO:0071219	83	0.027
cyclic nucleotide metabolic process	GO:0009187	59	0.027
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.027
positive regulation of antimicrobial peptide production	GO:0002225	1	0.027
interleukin 1 alpha secretion	GO:0050703	3	0.027	Mouse
development of primary male sexual characteristics	GO:0046546	88	0.027
single organismal cell cell adhesion	GO:0016337	131	0.027
nucleoside metabolic process	GO:0009116	246	0.027
appendage morphogenesis	GO:0035107	149	0.026
divalent metal ion transport	GO:0070838	172	0.026
regulation of cell cell adhesion mediated by cadherin	GO:2000047	2	0.026
placenta development	GO:0001890	140	0.026
cellular response to abiotic stimulus	GO:0071214	56	0.026
regulation of cohesin localization to chromatin	GO:0071922	1	0.026
negative regulation of leukocyte proliferation	GO:0070664	46	0.026
regulation of cellular response to oxidative stress	GO:1900407	19	0.026
response to x ray	GO:0010165	11	0.026
lipoprotein metabolic process	GO:0042157	43	0.026
dna endoreduplication	GO:0042023	4	0.026
regulation of membrane permeability	GO:0090559	18	0.026
regulation of necrotic cell death	GO:0010939	13	0.026	Mouse
negative regulation of intracellular signal transduction	GO:1902532	167	0.025
carbohydrate catabolic process	GO:0016052	32	0.025
synaptic transmission	GO:0007268	329	0.025
nucleoside monophosphate metabolic process	GO:0009123	85	0.025
regionalization	GO:0003002	337	0.025
intracellular mrna localization	GO:0008298	4	0.025
amide transport	GO:0042886	138	0.025

Casp3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.147
cancer	DOID:162	0.121
organ system cancer	DOID:0050686	0.081
disease of anatomical entity	DOID:7	0.079
nervous system disease	DOID:863	0.079
central nervous system disease	DOID:331	0.044
neurodegenerative disease	DOID:1289	0.044

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