IMP: Integrative Multi-species Prediction

Mus musculus

149 known processes

Casp8

caspase 8

(Aliases: CASP-8,Mch5,FLICE,MACH)

Entrez: 12370
Ensembl: ENSMUSG00000026029
UniProtKB: Q3U607
UniProtKB: A0A087WQT6
UniProtKB: O89110

Process Predictions
Disease Predictions

Casp8 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of necroptotic process	GO:0060544	10	0.999
ripoptosome assembly involved in necroptotic process	GO:1901026	6	0.999
regulation of cd8 positive alpha beta cytotoxic t cell extravasation	GO:2000452	2	0.999
necroptotic process	GO:0070266	21	0.999
regulation of defense response	GO:0031347	233	0.988	Mouse
programmed necrotic cell death	GO:0097300	28	0.973
t cell extravasation	GO:0072683	4	0.972
cd8 positive alpha beta t cell extravasation	GO:0035697	3	0.970
regulation of cd8 positive alpha beta t cell extravasation	GO:2000449	3	0.969
i kappab kinase nf kappab signaling	GO:0007249	85	0.961	Human Mouse
apoptotic signaling pathway	GO:0097190	306	0.960
cd8 positive alpha beta cytotoxic t cell extravasation	GO:0035698	2	0.935
positive regulation of extrinsic apoptotic signaling pathway	GO:2001238	34	0.920
regulation of cell activation	GO:0050865	289	0.911	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.897
positive regulation of t cell mediated cytotoxicity	GO:0001916	15	0.885
regulation of extrinsic apoptotic signaling pathway	GO:2001236	77	0.882
negative regulation of necrotic cell death	GO:0060547	11	0.871
activation of immune response	GO:0002253	138	0.869
necroptotic signaling pathway	GO:0097527	3	0.864
activation induced cell death of t cells	GO:0006924	10	0.863
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.861
defense response to other organism	GO:0098542	197	0.839
leukocyte proliferation	GO:0070661	172	0.818	Mouse
regulation of necrotic cell death	GO:0010939	13	0.808
t cell homeostasis	GO:0043029	35	0.792	Mouse
regulation of t cell proliferation	GO:0042129	92	0.780	Mouse
regulation of t cell mediated immunity	GO:0002709	34	0.752
t cell proliferation	GO:0042098	120	0.747	Mouse
positive regulation of cell death	GO:0010942	224	0.744
t cell mediated cytotoxicity	GO:0001913	26	0.743
immune effector process	GO:0002252	321	0.734
lymphocyte proliferation	GO:0046651	164	0.729	Mouse
regulation of cytokine production	GO:0001817	266	0.724	Mouse
negative regulation of immune system process	GO:0002683	209	0.724	Mouse
positive regulation of programmed cell death	GO:0043068	218	0.721
regulation of leukocyte apoptotic process	GO:2000106	56	0.719
regulation of t cell mediated cytotoxicity	GO:0001914	18	0.717
intrinsic apoptotic signaling pathway	GO:0097193	132	0.713	Mouse
necrotic cell death	GO:0070265	30	0.713
t cell activation	GO:0042110	289	0.704	Mouse
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	34	0.702
lymphocyte mediated immunity	GO:0002449	139	0.683
negative regulation of necroptotic process	GO:0060546	9	0.678
leukocyte mediated immunity	GO:0002443	174	0.660
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	145	0.653
adaptive immune response	GO:0002250	155	0.644
positive regulation of lymphocyte proliferation	GO:0050671	70	0.637
regulation of leukocyte proliferation	GO:0070663	121	0.635	Mouse
t cell mediated immunity	GO:0002456	50	0.629
lymphocyte differentiation	GO:0030098	242	0.627
lymphocyte homeostasis	GO:0002260	64	0.626	Mouse
positive regulation of apoptotic process	GO:0043065	217	0.626
cell killing	GO:0001906	67	0.619
positive regulation of defense response	GO:0031349	124	0.603
regulation of protein localization	GO:0032880	231	0.602	Mouse
positive regulation of innate immune response	GO:0045089	80	0.599
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002822	87	0.597
spleen development	GO:0048536	39	0.579
regulation of lymphocyte proliferation	GO:0050670	117	0.566	Mouse
positive regulation of t cell activation	GO:0050870	101	0.560
t cell differentiation in thymus	GO:0033077	77	0.557
positive regulation of adaptive immune response	GO:0002821	61	0.553
cytokine mediated signaling pathway	GO:0019221	115	0.546
t cell differentiation	GO:0030217	174	0.546
jnk cascade	GO:0007254	72	0.540
interleukin 2 production	GO:0032623	33	0.539
positive regulation of jnk cascade	GO:0046330	46	0.537
positive regulation of necrotic cell death	GO:0010940	1	0.525
regulation of alpha beta t cell activation	GO:0046634	53	0.524
cellular response to cytokine stimulus	GO:0071345	189	0.508
negative regulation of lymphocyte activation	GO:0051250	91	0.505	Mouse
cytokine production	GO:0001816	319	0.505	Mouse
cell type specific apoptotic process	GO:0097285	268	0.503
regulation of leukocyte mediated cytotoxicity	GO:0001910	38	0.498
regulation of leukocyte differentiation	GO:1902105	159	0.497	Human
antigen receptor mediated signaling pathway	GO:0050851	64	0.489
immune response regulating cell surface receptor signaling pathway	GO:0002768	80	0.473
regulation of adaptive immune response	GO:0002819	90	0.471
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002824	61	0.470
lymph node development	GO:0048535	18	0.470
positive regulation of cd8 positive alpha beta t cell extravasation	GO:2000451	2	0.464
macrophage differentiation	GO:0030225	20	0.461
defense response to bacterium	GO:0042742	119	0.458
positive regulation of immune effector process	GO:0002699	107	0.455
stress activated protein kinase signaling cascade	GO:0031098	81	0.443
t cell apoptotic process	GO:0070231	39	0.440
regulation of cysteine type endopeptidase activity	GO:2000116	65	0.431
t cell receptor signaling pathway	GO:0050852	46	0.427
extrinsic apoptotic signaling pathway	GO:0097191	126	0.425
regulation of innate immune response	GO:0045088	91	0.419
leukocyte mediated cytotoxicity	GO:0001909	62	0.418
positive regulation of cytokine production	GO:0001819	174	0.417	Mouse
innate immune response	GO:0045087	157	0.414
response to interleukin 12	GO:0070671	2	0.413
homeostasis of number of cells	GO:0048872	210	0.407	Mouse
regulation of kinase activity	GO:0043549	249	0.405	Mouse
regulation of peptidase activity	GO:0052547	96	0.397
response to organic cyclic compound	GO:0014070	198	0.396	Mouse
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.396
regulation of lymphocyte activation	GO:0051249	240	0.396	Mouse
regulation of t cell extravasation	GO:2000407	3	0.393
regulation of response to cytokine stimulus	GO:0060759	23	0.392
protein maturation	GO:0051604	176	0.390
response to molecule of bacterial origin	GO:0002237	143	0.386	Mouse
reactive oxygen species metabolic process	GO:0072593	84	0.384
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	55	0.373	Mouse
immune response activating signal transduction	GO:0002757	116	0.372
positive regulation of t cell proliferation	GO:0042102	52	0.369
regulation of hydrolase activity	GO:0051336	246	0.355
positive regulation of leukocyte proliferation	GO:0070665	73	0.355
negative regulation of molecular function	GO:0044092	258	0.352	Mouse
positive regulation of interleukin 2 production	GO:0032743	19	0.347
immune response activating cell surface receptor signaling pathway	GO:0002429	72	0.346
response to lipopolysaccharide	GO:0032496	128	0.341	Mouse
regulation of proteolysis	GO:0030162	164	0.337
regulation of tumor necrosis factor production	GO:0032680	49	0.326
regulation of cell killing	GO:0031341	40	0.323
hepatocyte apoptotic process	GO:0097284	11	0.323
activation of cysteine type endopeptidase activity	GO:0097202	27	0.320
intracellular protein transport	GO:0006886	204	0.314
leukocyte differentiation	GO:0002521	342	0.311
regulation of activated t cell proliferation	GO:0046006	16	0.310	Mouse
immune response regulating signaling pathway	GO:0002764	125	0.308
positive regulation of cell activation	GO:0050867	158	0.307
alpha beta t cell activation	GO:0046631	91	0.300
lymphocyte apoptotic process	GO:0070227	54	0.292
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902043	13	0.290
positive regulation of interleukin 8 production	GO:0032757	2	0.289
positive regulation of lymphocyte activation	GO:0051251	140	0.285
cellular response to lipopolysaccharide	GO:0071222	77	0.280
regulation of membrane potential	GO:0042391	192	0.273	Mouse
aromatic compound catabolic process	GO:0019439	286	0.272	Mouse
lipopolysaccharide mediated signaling pathway	GO:0031663	25	0.271
defense response to virus	GO:0051607	68	0.267
anion transport	GO:0006820	177	0.267
regulation of t cell apoptotic process	GO:0070232	28	0.264
leukocyte apoptotic process	GO:0071887	71	0.264
regulation of protein kinase activity	GO:0045859	232	0.262	Mouse
t cell migration	GO:0072678	19	0.257
stress activated mapk cascade	GO:0051403	80	0.256
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	45	0.256
regulation of cell cycle	GO:0051726	281	0.254	Mouse
positive regulation of interferon gamma production	GO:0032729	39	0.252
regulation of lymphocyte mediated immunity	GO:0002706	84	0.251
regulation of t cell activation	GO:0050863	170	0.250	Mouse
positive regulation of t cell extravasation	GO:2000409	2	0.250
positive regulation of hydrolase activity	GO:0051345	148	0.247
regulation of cell motility	GO:2000145	236	0.247
cellular response to peptidoglycan	GO:0071224	4	0.244
positive regulation of myeloid leukocyte differentiation	GO:0002763	26	0.243	Human
gland development	GO:0048732	330	0.236
regulation of alpha beta t cell proliferation	GO:0046640	18	0.233
regulation of endopeptidase activity	GO:0052548	89	0.233
regulation of homeostatic process	GO:0032844	182	0.232
innate immune response activating signal transduction	GO:0002758	50	0.231
positive regulation of response to cytokine stimulus	GO:0060760	11	0.231
protein autophosphorylation	GO:0046777	61	0.230
cellular ketone metabolic process	GO:0042180	84	0.230
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.230
lymphocyte migration	GO:0072676	26	0.230
protein oligomerization	GO:0051259	67	0.225
leukocyte migration	GO:0050900	124	0.222
thymus development	GO:0048538	41	0.220
regulation of cell migration	GO:0030334	219	0.220
epithelial tube morphogenesis	GO:0060562	303	0.217
positive regulation of cysteine type endopeptidase activity	GO:2001056	39	0.216
protein processing	GO:0016485	163	0.215
regulation of interleukin 8 production	GO:0032677	3	0.214
positive regulation of macrophage differentiation	GO:0045651	5	0.212	Human
establishment of protein localization to organelle	GO:0072594	118	0.210
interleukin 8 production	GO:0032637	4	0.203
regulation of intracellular transport	GO:0032386	159	0.202
neuron apoptotic process	GO:0051402	142	0.201	Mouse
nik nf kappab signaling	GO:0038061	14	0.201
zymogen activation	GO:0031638	41	0.200
regulation of transferase activity	GO:0051338	263	0.200	Mouse
cellular response to oxidative stress	GO:0034599	76	0.198	Mouse
signal transduction in absence of ligand	GO:0038034	55	0.195	Mouse
tumor necrosis factor production	GO:0032640	50	0.194
cellular response to biotic stimulus	GO:0071216	92	0.193
regulation of intrinsic apoptotic signaling pathway	GO:2001242	61	0.193
regulation of alpha beta t cell differentiation	GO:0046637	35	0.192
lymphocyte activation involved in immune response	GO:0002285	93	0.189
negative regulation of ripoptosome assembly involved in necroptotic process	GO:1902443	3	0.187
regulation of interferon gamma production	GO:0032649	57	0.187
regulation of interleukin 6 production	GO:0032675	55	0.186
regulation of inflammatory response	GO:0050727	147	0.186	Mouse
nucleotide binding oligomerization domain containing signaling pathway	GO:0070423	6	0.184
mapk cascade	GO:0000165	281	0.182
nitrogen compound transport	GO:0071705	271	0.180
regulation of mapk cascade	GO:0043408	248	0.179
cellular response to dna damage stimulus	GO:0006974	207	0.179	Mouse
regulation of tumor necrosis factor superfamily cytokine production	GO:1903555	50	0.177
regulation of intracellular protein transport	GO:0033157	82	0.174
response to growth factor	GO:0070848	198	0.173
blood vessel morphogenesis	GO:0048514	285	0.173
regulation of secretion	GO:0051046	274	0.170	Mouse
positive regulation of tumor necrosis factor production	GO:0032760	30	0.169
regulation of lymphocyte apoptotic process	GO:0070228	41	0.169
positive regulation of mapk cascade	GO:0043410	170	0.169
chemokine production	GO:0032602	34	0.167
cell activation involved in immune response	GO:0002263	126	0.163
leukocyte homeostasis	GO:0001776	79	0.163	Mouse
regulation of interleukin 2 production	GO:0032663	28	0.160
cellular amine metabolic process	GO:0044106	44	0.158
positive regulation of alpha beta t cell differentiation	GO:0046638	28	0.156
cellular response to growth factor stimulus	GO:0071363	197	0.152
regulation of reactive oxygen species metabolic process	GO:2000377	40	0.152
protein import into nucleus	GO:0006606	95	0.148
tumor necrosis factor superfamily cytokine production	GO:0071706	51	0.148
cellular extravasation	GO:0045123	17	0.147
myeloid cell differentiation	GO:0030099	233	0.145
regulation of myeloid leukocyte differentiation	GO:0002761	58	0.143	Human
glycoprotein biosynthetic process	GO:0009101	89	0.142
positive regulation of tumor necrosis factor superfamily cytokine production	GO:1903557	31	0.141
regulation of establishment of protein localization	GO:0070201	181	0.138	Mouse
ripoptosome assembly	GO:0097343	6	0.136
epidermis development	GO:0008544	187	0.135	Mouse
activation of innate immune response	GO:0002218	56	0.134
neuron death	GO:0070997	154	0.131	Mouse
response to organonitrogen compound	GO:0010243	246	0.130	Mouse
organic acid transport	GO:0015849	101	0.130
positive regulation of secretion	GO:0051047	130	0.130	Mouse
amine metabolic process	GO:0009308	45	0.129
regulation of cd4 positive alpha beta t cell activation	GO:2000514	24	0.128
antibacterial peptide production	GO:0002778	2	0.124
b cell activation	GO:0042113	161	0.121	Mouse
pattern recognition receptor signaling pathway	GO:0002221	47	0.120
positive regulation of proteolysis	GO:0045862	85	0.119
organonitrogen compound biosynthetic process	GO:1901566	192	0.118
organic cyclic compound catabolic process	GO:1901361	295	0.116	Mouse
membrane organization	GO:0061024	245	0.116
regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902041	22	0.115
positive regulation of nf kappab transcription factor activity	GO:0051092	30	0.115
fibril organization	GO:0097435	2	0.114
cellular response to lipid	GO:0071396	145	0.114	Mouse
negative regulation of b cell activation	GO:0050869	27	0.114	Mouse
alpha beta t cell differentiation	GO:0046632	69	0.113
macromolecule deacylation	GO:0098732	37	0.112
carbohydrate derivative biosynthetic process	GO:1901137	183	0.108
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	36	0.107
positive regulation of type i interferon mediated signaling pathway	GO:0060340	4	0.107
peptide transport	GO:0015833	133	0.107
transmembrane transport	GO:0055085	412	0.106
ion transmembrane transport	GO:0034220	361	0.105
positive regulation of peptidase activity	GO:0010952	49	0.105
glycosyl compound metabolic process	GO:1901657	246	0.104
cation homeostasis	GO:0055080	212	0.102
intracellular receptor signaling pathway	GO:0030522	74	0.101
glycoprotein metabolic process	GO:0009100	116	0.101
macromolecule catabolic process	GO:0009057	281	0.100	Human Mouse
negative regulation of phosphorus metabolic process	GO:0010563	184	0.100	Mouse
regulation of cellular ketone metabolic process	GO:0010565	66	0.100
positive regulation of endopeptidase activity	GO:0010950	43	0.099
lipid localization	GO:0010876	126	0.097
multicellular organism growth	GO:0035264	161	0.097
negative regulation of homeostatic process	GO:0032845	71	0.096
protein homooligomerization	GO:0051260	43	0.094
purine nucleotide metabolic process	GO:0006163	302	0.094
regulation of response to wounding	GO:1903034	189	0.092	Mouse
regulation of cellular catabolic process	GO:0031329	242	0.092	Mouse
positive regulation of protein transport	GO:0051222	93	0.091	Mouse
positive regulation of protein modification process	GO:0031401	299	0.091
peptidyl serine modification	GO:0018209	83	0.090
positive regulation of t helper 1 cell differentiation	GO:0045627	4	0.090
cellular response to molecule of bacterial origin	GO:0071219	83	0.090
negative regulation of cell proliferation	GO:0008285	296	0.089	Mouse
cellular macromolecule catabolic process	GO:0044265	206	0.088	Human Mouse
cellular response to type i interferon	GO:0071357	10	0.087
positive regulation of leukocyte mediated cytotoxicity	GO:0001912	31	0.086
positive regulation of intrinsic apoptotic signaling pathway	GO:2001244	25	0.086
cellular response to external stimulus	GO:0071496	88	0.085	Human
positive regulation of protein kinase activity	GO:0045860	144	0.084
regulation of protein deacetylation	GO:0090311	17	0.083
negative regulation of t cell apoptotic process	GO:0070233	18	0.083
erk1 and erk2 cascade	GO:0070371	77	0.083
cellular amino acid metabolic process	GO:0006520	103	0.082
regulation of erk1 and erk2 cascade	GO:0070372	71	0.082
cellular nitrogen compound catabolic process	GO:0044270	280	0.082	Mouse
positive regulation of t cell differentiation	GO:0045582	52	0.081
negative regulation of phosphorylation	GO:0042326	166	0.081	Mouse
cellular ion homeostasis	GO:0006873	165	0.079
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	26	0.078
spermatogenesis	GO:0007283	284	0.077
cytoplasmic transport	GO:0016482	234	0.077
nucleoside phosphate metabolic process	GO:0006753	338	0.077
autophagy	GO:0006914	45	0.077	Mouse
positive regulation of alpha beta t cell activation	GO:0046635	39	0.076
neural tube development	GO:0021915	160	0.076
regulation of antibacterial peptide production	GO:0002786	1	0.076
sensory perception	GO:0007600	245	0.075	Mouse
regulation of secretion by cell	GO:1903530	249	0.075	Mouse
protein localization to nucleus	GO:0034504	121	0.075
interferon gamma production	GO:0032609	67	0.074
cd4 positive alpha beta t cell differentiation	GO:0043367	41	0.074
cellular response to organonitrogen compound	GO:0071417	145	0.074
positive regulation of kinase activity	GO:0033674	155	0.073
negative regulation of cellular amine metabolic process	GO:0033239	1	0.073
regulation of cellular amino acid metabolic process	GO:0006521	5	0.071
regulation of interleukin 1 alpha production	GO:0032650	4	0.070	Mouse
peptidyl amino acid modification	GO:0018193	336	0.069
regulation of immunological synapse formation	GO:2000520	2	0.069
organic anion transport	GO:0015711	137	0.069
regulation of macrophage differentiation	GO:0045649	9	0.069	Human
negative regulation of t cell activation	GO:0050868	65	0.068	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	247	0.068	Mouse
type i interferon production	GO:0032606	29	0.068
positive regulation of transferase activity	GO:0051347	167	0.066
positive regulation of interleukin 6 production	GO:0032755	37	0.066
negative regulation of phosphate metabolic process	GO:0045936	184	0.066	Mouse
regulation of protein transport	GO:0051223	163	0.066	Mouse
alpha beta t cell differentiation involved in immune response	GO:0002293	30	0.066
positive regulation of leukocyte differentiation	GO:1902107	86	0.066	Human
forebrain development	GO:0030900	302	0.065
regulation of lymphocyte differentiation	GO:0045619	107	0.065
organonitrogen compound catabolic process	GO:1901565	264	0.064
regulation of defense response to bacterium	GO:1900424	3	0.064
maintenance of location	GO:0051235	89	0.064
positive regulation of lymphocyte differentiation	GO:0045621	61	0.064
positive regulation of intracellular transport	GO:0032388	70	0.063
protein targeting	GO:0006605	143	0.063
positive regulation of leukocyte mediated immunity	GO:0002705	70	0.062
sequestering of calcium ion	GO:0051208	18	0.062
regulation of cellular amine metabolic process	GO:0033238	20	0.062
ribonucleotide metabolic process	GO:0009259	291	0.061
cellular homeostasis	GO:0019725	240	0.061
regulation of cellular component biogenesis	GO:0044087	181	0.061
response to water	GO:0009415	1	0.061
microtubule based process	GO:0007017	236	0.061
regulation of antigen receptor mediated signaling pathway	GO:0050854	29	0.061
regulation of antibacterial peptide biosynthetic process	GO:0002808	1	0.060
cellular response to hormone stimulus	GO:0032870	150	0.059	Mouse
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.059
glial cell apoptotic process	GO:0034349	3	0.059	Mouse
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	57	0.058
regulation of jnk cascade	GO:0046328	62	0.058
lipid biosynthetic process	GO:0008610	179	0.058
cd4 positive alpha beta t cell activation	GO:0035710	45	0.058
release of cytochrome c from mitochondria	GO:0001836	23	0.057	Mouse
positive regulation of t cell mediated immunity	GO:0002711	24	0.057
regulation of myeloid cell differentiation	GO:0045637	96	0.057	Human
ribose phosphate metabolic process	GO:0019693	291	0.057
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	1	0.057
digestive system development	GO:0055123	200	0.056
axonogenesis	GO:0007409	274	0.056
regulation of autophagy	GO:0010506	30	0.056	Mouse
negative regulation of cell activation	GO:0050866	111	0.056	Mouse
inflammatory response	GO:0006954	244	0.055	Mouse
monocarboxylic acid transport	GO:0015718	44	0.055
positive regulation of antimicrobial peptide production	GO:0002225	1	0.055
embryonic epithelial tube formation	GO:0001838	130	0.055
compound eye development	GO:0048749	1	0.054
regulation of protein complex assembly	GO:0043254	83	0.054
nucleobase containing small molecule metabolic process	GO:0055086	352	0.054
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	1	0.054
positive regulation of lymphocyte mediated immunity	GO:0002708	62	0.053
positive regulation of erk1 and erk2 cascade	GO:0070374	47	0.053
regulation of type i interferon mediated signaling pathway	GO:0060338	7	0.053
positive regulation of phosphatase activity	GO:0010922	4	0.052
cation transport	GO:0006812	399	0.052
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.052	Human
positive regulation of protein phosphorylation	GO:0001934	242	0.052
rhythmic process	GO:0048511	174	0.052
cellular chemical homeostasis	GO:0055082	215	0.051
regulation of protein secretion	GO:0050708	82	0.051	Mouse
angiogenesis	GO:0001525	201	0.051
keratinocyte differentiation	GO:0030216	48	0.050	Mouse
regulation of t helper cell differentiation	GO:0045622	14	0.050
translation	GO:0006412	93	0.050
interleukin 6 production	GO:0032635	58	0.050
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	62	0.049
negative regulation of lymphocyte apoptotic process	GO:0070229	24	0.049
protein deacetylation	GO:0006476	32	0.048
protein localization to organelle	GO:0033365	185	0.048
sequestering of metal ion	GO:0051238	19	0.048
negative regulation of cellular component organization	GO:0051129	194	0.048
regulation of t helper 1 cell differentiation	GO:0045625	7	0.048
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	16	0.048
ear development	GO:0043583	200	0.047
negative regulation of t cell proliferation	GO:0042130	38	0.047	Mouse
male gamete generation	GO:0048232	285	0.047
regulation of cellular response to stress	GO:0080135	159	0.047
regulation of t cell migration	GO:2000404	12	0.047
organelle localization	GO:0051640	179	0.046
regulation of protein maturation	GO:1903317	96	0.046
regulation of lymphocyte migration	GO:2000401	14	0.046
dna catabolic process endonucleolytic	GO:0000737	15	0.046	Mouse
anion transmembrane transport	GO:0098656	71	0.045
type i interferon signaling pathway	GO:0060337	10	0.045
peptidyl tyrosine modification	GO:0018212	145	0.045
purine ribonucleoside metabolic process	GO:0046128	241	0.045
cellular amide metabolic process	GO:0043603	58	0.045
protein deacylation	GO:0035601	36	0.045
negative thymic t cell selection	GO:0045060	12	0.045
positive regulation of protein oligomerization	GO:0032461	4	0.044
protein import	GO:0017038	101	0.044
positive regulation of antimicrobial humoral response	GO:0002760	2	0.044
regulation of organelle organization	GO:0033043	289	0.044
membrane depolarization	GO:0051899	64	0.044	Mouse
regulation of antimicrobial humoral response	GO:0002759	3	0.043
regulation of t cell differentiation	GO:0045580	83	0.043
endodermal cell fate specification	GO:0001714	4	0.043
humoral immune response	GO:0006959	57	0.043
cytokine biosynthetic process	GO:0042089	68	0.043
positive regulation of cellular amine metabolic process	GO:0033240	5	0.043
response to interleukin 1	GO:0070555	11	0.042
regulation of body fluid levels	GO:0050878	162	0.042
mitotic cell cycle	GO:0000278	195	0.042
positive regulation of defense response to bacterium	GO:1900426	1	0.042
ribose phosphate biosynthetic process	GO:0046390	59	0.042
regulation of cell cycle process	GO:0010564	160	0.042
positive regulation of stress activated mapk cascade	GO:0032874	48	0.041
stem cell differentiation	GO:0048863	268	0.041
muscle cell differentiation	GO:0042692	261	0.041
amide transport	GO:0042886	138	0.041
positive regulation of alpha beta t cell proliferation	GO:0046641	12	0.041
regulation of protein serine threonine kinase activity	GO:0071900	157	0.041	Mouse
antibacterial peptide biosynthetic process	GO:0002780	2	0.040
wnt signaling pathway	GO:0016055	188	0.040
regulation of antimicrobial peptide biosynthetic process	GO:0002805	1	0.040
leukocyte activation involved in immune response	GO:0002366	126	0.040
skin development	GO:0043588	220	0.040	Mouse
toll like receptor signaling pathway	GO:0002224	38	0.040
organophosphate biosynthetic process	GO:0090407	122	0.040
regulation of protein targeting	GO:1903533	61	0.039
myeloid cell homeostasis	GO:0002262	114	0.039
respiratory system development	GO:0060541	190	0.039
nuclear transport	GO:0051169	139	0.039
cellular response to steroid hormone stimulus	GO:0071383	33	0.039	Mouse
regulation of stress activated mapk cascade	GO:0032872	69	0.039
peptidyl serine phosphorylation	GO:0018105	74	0.039
branching morphogenesis of an epithelial tube	GO:0048754	159	0.039
endomembrane system organization	GO:0010256	147	0.039
negative regulation of defense response	GO:0031348	77	0.038
antimicrobial peptide production	GO:0002775	2	0.038
epithelial cell proliferation	GO:0050673	174	0.038
response to starvation	GO:0042594	65	0.038
positive regulation of protein deacetylation	GO:0090312	9	0.038
lung development	GO:0030324	164	0.038
nucleoside metabolic process	GO:0009116	246	0.038
cellular lipid metabolic process	GO:0044255	323	0.037
regulation of nucleocytoplasmic transport	GO:0046822	73	0.037
g protein coupled receptor signaling pathway	GO:0007186	243	0.037
lipid transport	GO:0006869	98	0.037
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.037
ribonucleoside catabolic process	GO:0042454	206	0.037
regulation of ion transmembrane transporter activity	GO:0032412	54	0.037
ribonucleotide catabolic process	GO:0009261	208	0.037
inflammatory response to antigenic stimulus	GO:0002437	30	0.036
nucleoside phosphate catabolic process	GO:1901292	222	0.036
purine ribonucleoside triphosphate metabolic process	GO:0009205	220	0.036
defense response to gram negative bacterium	GO:0050829	28	0.036
extracellular structure organization	GO:0043062	148	0.036
regulation of leukocyte mediated immunity	GO:0002703	104	0.036
ubiquitin dependent protein catabolic process	GO:0006511	129	0.036
cellular metal ion homeostasis	GO:0006875	151	0.036
regulation of osteoblast differentiation	GO:0045667	67	0.036
dephosphorylation	GO:0016311	129	0.035
purine ribonucleotide metabolic process	GO:0009150	290	0.035
t cell activation involved in immune response	GO:0002286	43	0.035
divalent inorganic cation homeostasis	GO:0072507	138	0.034
response to endoplasmic reticulum stress	GO:0034976	53	0.034	Mouse
cd4 positive alpha beta t cell differentiation involved in immune response	GO:0002294	28	0.034
anatomical structure homeostasis	GO:0060249	145	0.034
purine containing compound metabolic process	GO:0072521	311	0.034
positive regulation of cd4 positive alpha beta t cell differentiation	GO:0043372	14	0.033
purine nucleoside metabolic process	GO:0042278	241	0.033
vesicle organization	GO:0016050	60	0.033
positive regulation of necroptotic process	GO:0060545	1	0.033
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.033
regulation of neuron differentiation	GO:0045664	281	0.032
purine containing compound catabolic process	GO:0072523	213	0.032
urogenital system development	GO:0001655	261	0.032
dna metabolic process	GO:0006259	303	0.032	Mouse
myeloid leukocyte differentiation	GO:0002573	119	0.032
carboxylic acid transport	GO:0046942	100	0.032
nuclear import	GO:0051170	95	0.032
glycerolipid biosynthetic process	GO:0045017	50	0.032
small molecule biosynthetic process	GO:0044283	132	0.032
cytokine secretion	GO:0050663	72	0.031	Mouse
posttranscriptional regulation of gene expression	GO:0010608	155	0.031
regulation of neuron death	GO:1901214	134	0.031	Mouse
actin filament polymerization	GO:0030041	44	0.031
regulation of interleukin 1 beta secretion	GO:0050706	15	0.030	Mouse
regulation of antimicrobial peptide production	GO:0002784	1	0.030
cardiac muscle cell contraction	GO:0086003	7	0.030
positive regulation of interferon alpha production	GO:0032727	4	0.030

Casp8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability	Func Analog Org
immune system disease	DOID:2914	0.152
disease of anatomical entity	DOID:7	0.152
hypersensitivity reaction disease	DOID:0060056	0.152
disease of cellular proliferation	DOID:14566	0.053	Human
cancer	DOID:162	0.042	Human
organ system cancer	DOID:0050686	0.042	Human
disease by infectious agent	DOID:0050117	0.031

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