IMP: Integrative Multi-species Prediction

Mus musculus

134 known processes

Acvr2a

activin receptor IIA

(Aliases: TactrII,ActrIIa,Acvr2)

Entrez: 11480
Ensembl: ENSMUSG00000052155
UniProtKB: A2AI38
UniProtKB: P27038
UniProtKB: Q8BRV4

Process Predictions
Disease Predictions

Acvr2a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
insulin secretion	GO:0030073	89	0.649	Mouse
urogenital system development	GO:0001655	261	0.531	Mouse
positive regulation of protein kinase activity	GO:0045860	144	0.496	Mouse
regulation of activin receptor signaling pathway	GO:0032925	10	0.467	Human
mesoderm development	GO:0007498	100	0.459
activin receptor signaling pathway	GO:0032924	18	0.454	Human Rat
positive regulation of protein phosphorylation	GO:0001934	242	0.443	Human Mouse
bmp signaling pathway	GO:0030509	93	0.403
amide transport	GO:0042886	138	0.398	Mouse
renal system development	GO:0072001	225	0.392	Mouse
regulation of neuron projection development	GO:0010975	169	0.386
t cell activation	GO:0042110	289	0.377
regulation of hormone levels	GO:0010817	211	0.375	Mouse Rat
peptide secretion	GO:0002790	114	0.368	Mouse
mapk cascade	GO:0000165	281	0.366
positive regulation of protein modification process	GO:0031401	299	0.348	Human Mouse
regulation of cell morphogenesis involved in differentiation	GO:0010769	151	0.341
regulation of neuron differentiation	GO:0045664	281	0.340
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	112	0.335
kidney development	GO:0001822	213	0.334	Mouse
peptide hormone secretion	GO:0030072	109	0.332	Mouse
myeloid cell differentiation	GO:0030099	233	0.305	Human
cellular response to growth factor stimulus	GO:0071363	197	0.303	Human
epithelial tube morphogenesis	GO:0060562	303	0.297
skeletal system development	GO:0001501	356	0.290
peptide transport	GO:0015833	133	0.283	Mouse
leukocyte differentiation	GO:0002521	342	0.281
regulation of cellular amino acid metabolic process	GO:0006521	5	0.279
hormone secretion	GO:0046879	128	0.272	Mouse Rat
regulation of anatomical structure size	GO:0090066	178	0.270
chemotaxis	GO:0006935	247	0.269
cell adhesion	GO:0007155	329	0.269
regulation of kinase activity	GO:0043549	249	0.265	Mouse
positive regulation of activin receptor signaling pathway	GO:0032927	3	0.263	Human
regulation of secretion	GO:0051046	274	0.260	Rat
positive regulation of neuron differentiation	GO:0045666	141	0.260
camera type eye development	GO:0043010	266	0.259	Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	247	0.259
mesenchyme development	GO:0060485	152	0.255	Zebrafish
homeostasis of number of cells	GO:0048872	210	0.240	Human
epithelial cell proliferation	GO:0050673	174	0.232
positive regulation of transferase activity	GO:0051347	167	0.231	Mouse
positive regulation of cell development	GO:0010720	237	0.229
negative regulation of cell proliferation	GO:0008285	296	0.228
regulation of cellular amine metabolic process	GO:0033238	20	0.226
regulation of cellular component biogenesis	GO:0044087	181	0.225
regulation of cell projection organization	GO:0031344	206	0.220
determination of left right symmetry	GO:0007368	80	0.219
inflammatory response	GO:0006954	244	0.217
cellular amine metabolic process	GO:0044106	44	0.217
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	194	0.212
sperm ejaculation	GO:0042713	1	0.207
positive regulation of cell projection organization	GO:0031346	95	0.206
palate development	GO:0060021	76	0.203	Mouse
morphogenesis of a branching epithelium	GO:0061138	193	0.203
cellular ketone metabolic process	GO:0042180	84	0.199
regulation of cell activation	GO:0050865	289	0.197
cellular amino acid metabolic process	GO:0006520	103	0.196
epidermis development	GO:0008544	187	0.194
regulation of protein kinase activity	GO:0045859	232	0.190	Mouse
branching morphogenesis of an epithelial tube	GO:0048754	159	0.187
regulation of protein localization	GO:0032880	231	0.187
cartilage development	GO:0051216	140	0.184	Zebrafish
regulation of mapk cascade	GO:0043408	248	0.184
circulatory system process	GO:0003013	197	0.181
ossification	GO:0001503	216	0.180	Human
digestive tract development	GO:0048565	190	0.178
amine metabolic process	GO:0009308	45	0.174
response to sterol	GO:0036314	4	0.173
multicellular organism growth	GO:0035264	161	0.171
spermatogenesis	GO:0007283	284	0.171
regulation of bmp signaling pathway	GO:0030510	60	0.170
respiratory tube development	GO:0030323	167	0.169	Mouse
regulation of apoptotic signaling pathway	GO:2001233	197	0.166
peptidyl amino acid modification	GO:0018193	336	0.164
regulation of cellular component size	GO:0032535	121	0.163
positive regulation of nervous system development	GO:0051962	221	0.161
regulation of synaptic growth at neuromuscular junction	GO:0008582	4	0.159
morphogenesis of embryonic epithelium	GO:0016331	159	0.158
digestive system development	GO:0055123	200	0.158
sensory organ morphogenesis	GO:0090596	242	0.155
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.155
gland development	GO:0048732	330	0.154
skeletal system morphogenesis	GO:0048705	203	0.154	Mouse
cytoplasmic transport	GO:0016482	234	0.153
regulation of t cell activation	GO:0050863	170	0.149
negative regulation of phosphorus metabolic process	GO:0010563	184	0.148
negative regulation of synapse assembly	GO:0051964	3	0.148
myeloid leukocyte differentiation	GO:0002573	119	0.147
positive regulation of mapk cascade	GO:0043410	170	0.145
response to monosaccharide	GO:0034284	67	0.144	Mouse
tissue remodeling	GO:0048771	102	0.143	Mouse
metal ion homeostasis	GO:0055065	189	0.143
female gamete generation	GO:0007292	74	0.142
heart morphogenesis	GO:0003007	178	0.142
regulation of lymphocyte activation	GO:0051249	240	0.142
cation homeostasis	GO:0055080	212	0.140
skin development	GO:0043588	220	0.139
venous blood vessel development	GO:0060841	13	0.139	Mouse
response to organonitrogen compound	GO:0010243	246	0.138
stem cell development	GO:0048864	219	0.138	Zebrafish
germ cell development	GO:0007281	185	0.137
blood vessel morphogenesis	GO:0048514	285	0.133
regulation of transferase activity	GO:0051338	263	0.133	Mouse
t cell differentiation	GO:0030217	174	0.130
negative regulation of phosphate metabolic process	GO:0045936	184	0.128
ubiquitin dependent protein catabolic process	GO:0006511	129	0.127
regulation of leukocyte differentiation	GO:1902105	159	0.126
neuron projection guidance	GO:0097485	141	0.126
response to growth factor	GO:0070848	198	0.125	Human
cellular homeostasis	GO:0019725	240	0.125
cellular protein catabolic process	GO:0044257	155	0.125
positive regulation of programmed cell death	GO:0043068	218	0.124
cytokine production	GO:0001816	319	0.121
regulation of cellular ketone metabolic process	GO:0010565	66	0.121
mesendoderm development	GO:0048382	3	0.120
small gtpase mediated signal transduction	GO:0007264	97	0.119
blood vessel remodeling	GO:0001974	33	0.119	Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	43	0.117	Human
hindbrain development	GO:0030902	128	0.117	Zebrafish
endocrine system development	GO:0035270	98	0.115
striated muscle tissue development	GO:0014706	293	0.115
protein ubiquitination	GO:0016567	171	0.114
single organismal cell cell adhesion	GO:0016337	131	0.113
positive regulation of cellular amine metabolic process	GO:0033240	5	0.113
stem cell differentiation	GO:0048863	268	0.113	Zebrafish
regulation of defense response	GO:0031347	233	0.112
protein modification by small protein conjugation	GO:0032446	187	0.112
organonitrogen compound catabolic process	GO:1901565	264	0.110
metencephalon development	GO:0022037	89	0.109
regulation of cellular catabolic process	GO:0031329	242	0.109
regulation of secretion by cell	GO:1903530	249	0.109	Rat
b cell activation	GO:0042113	161	0.106
positive regulation of cellular amino acid metabolic process	GO:0045764	3	0.106
intracellular protein transport	GO:0006886	204	0.106
endoderm development	GO:0007492	45	0.105
negative regulation of protein metabolic process	GO:0051248	282	0.105
positive regulation of neuron projection development	GO:0010976	79	0.105
negative regulation of immune system process	GO:0002683	209	0.104
neural tube development	GO:0021915	160	0.102
endocytosis	GO:0006897	168	0.102
male gamete generation	GO:0048232	285	0.101
positive regulation of kinase activity	GO:0033674	155	0.100	Mouse
organ growth	GO:0035265	117	0.100	Mouse
regulation of cell migration	GO:0030334	219	0.099
dna metabolic process	GO:0006259	303	0.099
blood circulation	GO:0008015	195	0.097
regulation of intracellular transport	GO:0032386	159	0.097
mesenchymal cell development	GO:0014031	93	0.097	Zebrafish
negative regulation of phosphorylation	GO:0042326	166	0.096
gastrulation	GO:0007369	116	0.096
regulation of organ morphogenesis	GO:2000027	144	0.096
proteolysis involved in cellular protein catabolic process	GO:0051603	147	0.096
single organism cell adhesion	GO:0098602	156	0.095
synapse organization	GO:0050808	125	0.095
modification dependent protein catabolic process	GO:0019941	133	0.094
nitrogen compound transport	GO:0071705	271	0.094	Mouse
protein modification by small protein conjugation or removal	GO:0070647	207	0.094
regulation of establishment of protein localization	GO:0070201	181	0.093
positive regulation of cell activation	GO:0050867	158	0.093
mesenchymal cell differentiation	GO:0048762	107	0.092	Zebrafish
cellular chemical homeostasis	GO:0055082	215	0.092
regulation of cytokine production	GO:0001817	266	0.092
respiratory system development	GO:0060541	190	0.092	Mouse
axonogenesis	GO:0007409	274	0.092
digestive tract morphogenesis	GO:0048546	147	0.091
erythrocyte differentiation	GO:0030218	88	0.090	Human
axon guidance	GO:0007411	141	0.089
regulation of protein serine threonine kinase activity	GO:0071900	157	0.089
response to molecule of bacterial origin	GO:0002237	143	0.087
negative regulation of nervous system development	GO:0051961	156	0.086
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	61	0.085
response to organic cyclic compound	GO:0014070	198	0.084
developmental maturation	GO:0021700	193	0.083
regulation of reproductive process	GO:2000241	66	0.083
somitogenesis	GO:0001756	69	0.082
negative regulation of protein modification process	GO:0031400	163	0.082
endothelial cell differentiation	GO:0045446	41	0.082	Mouse
meiotic cell cycle	GO:0051321	122	0.082
pancreas development	GO:0031016	57	0.081	Mouse
cellular response to lipid	GO:0071396	145	0.081
regulation of osteoblast differentiation	GO:0045667	67	0.081	Human
peptidyl serine phosphorylation	GO:0018105	74	0.081
embryonic epithelial tube formation	GO:0001838	130	0.081
maintenance of location	GO:0051235	89	0.080
positive regulation of cellular component biogenesis	GO:0044089	94	0.080
embryonic skeletal system development	GO:0048706	120	0.079
negative regulation of cellular protein metabolic process	GO:0032269	247	0.079
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry	GO:1900094	2	0.079
lymphocyte proliferation	GO:0046651	164	0.079
leukocyte proliferation	GO:0070661	172	0.079
protein targeting	GO:0006605	143	0.078
purine ribonucleoside triphosphate catabolic process	GO:0009207	199	0.078
kidney epithelium development	GO:0072073	121	0.078
muscle system process	GO:0003012	141	0.077
apoptotic signaling pathway	GO:0097190	306	0.077
morphogenesis of a branching structure	GO:0001763	203	0.077
positive regulation of ossification	GO:0045778	47	0.076	Human
odontogenesis	GO:0042476	78	0.076	Mouse
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.076
transforming growth factor beta receptor signaling pathway	GO:0007179	71	0.075
connective tissue development	GO:0061448	179	0.075	Zebrafish
response to insulin	GO:0032868	100	0.074
formation of primary germ layer	GO:0001704	77	0.074
nodal signaling pathway involved in determination of left right asymmetry	GO:0038107	2	0.073
peptidyl serine modification	GO:0018209	83	0.073
germline cell cycle switching mitotic to meiotic cell cycle	GO:0051729	1	0.073
lipid localization	GO:0010876	126	0.072
cell growth	GO:0016049	130	0.072
cation transport	GO:0006812	399	0.072
heterocycle catabolic process	GO:0046700	280	0.071
regulation of ion transport	GO:0043269	215	0.071
regulation of homeostatic process	GO:0032844	182	0.071	Human
ameboidal type cell migration	GO:0001667	128	0.070	Zebrafish
mammary gland morphogenesis	GO:0060443	54	0.070
cellular metal ion homeostasis	GO:0006875	151	0.070
regionalization	GO:0003002	337	0.070
ras protein signal transduction	GO:0007265	77	0.070
stress activated mapk cascade	GO:0051403	80	0.070
regulation of lymphocyte proliferation	GO:0050670	117	0.070
positive regulation of cellular catabolic process	GO:0031331	148	0.069
positive regulation of apoptotic signaling pathway	GO:2001235	95	0.069
wnt signaling pathway	GO:0016055	188	0.069
adaptive immune response	GO:0002250	155	0.068
regulation of protein transport	GO:0051223	163	0.068
response to transforming growth factor beta	GO:0071559	88	0.068
guanosine containing compound metabolic process	GO:1901068	144	0.068
modification dependent macromolecule catabolic process	GO:0043632	133	0.068
jnk cascade	GO:0007254	72	0.068
positive regulation of reproductive process	GO:2000243	19	0.068
ribonucleotide metabolic process	GO:0009259	291	0.068
response to lipopolysaccharide	GO:0032496	128	0.068
forebrain development	GO:0030900	302	0.068
regulation of inflammatory response	GO:0050727	147	0.067
lipid biosynthetic process	GO:0008610	179	0.067
cognition	GO:0050890	149	0.067
regulation of vesicle mediated transport	GO:0060627	139	0.067
neural tube formation	GO:0001841	108	0.067
response to cholesterol	GO:0070723	4	0.067
neural crest cell differentiation	GO:0014033	54	0.067	Zebrafish
regulation of cell adhesion	GO:0030155	154	0.066
response to peptide	GO:1901652	136	0.066
positive regulation of growth	GO:0045927	104	0.066
regulation of response to wounding	GO:1903034	189	0.066
regulation of cell motility	GO:2000145	236	0.066
lymphocyte differentiation	GO:0030098	242	0.065
extrinsic apoptotic signaling pathway	GO:0097191	126	0.065
t cell proliferation	GO:0042098	120	0.065
establishment of protein localization to organelle	GO:0072594	118	0.064
appendage development	GO:0048736	166	0.064
regulation of muscle tissue development	GO:1901861	97	0.064
retina development in camera type eye	GO:0060041	119	0.064	Mouse
limb morphogenesis	GO:0035108	149	0.063
cellular ion homeostasis	GO:0006873	165	0.063
positive regulation of cell migration	GO:0030335	109	0.063
angiogenesis	GO:0001525	201	0.063
ribonucleoside triphosphate metabolic process	GO:0009199	220	0.063
negative regulation of cellular amine metabolic process	GO:0033239	1	0.062
establishment of organelle localization	GO:0051656	122	0.062
regulation of organelle organization	GO:0033043	289	0.062
positive regulation of protein transport	GO:0051222	93	0.061
embryonic heart tube morphogenesis	GO:0003143	51	0.061
peptidyl threonine modification	GO:0018210	31	0.061
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	72	0.061
gastrulation with mouth forming second	GO:0001702	29	0.061
regulation of multi organism process	GO:0043900	111	0.061
positive regulation of cell cycle	GO:0045787	92	0.061
organic cyclic compound catabolic process	GO:1901361	295	0.061
regulation of t cell differentiation	GO:0045580	83	0.060
primary neural tube formation	GO:0014020	95	0.060
protein catabolic process	GO:0030163	221	0.060
cellular response to transforming growth factor beta stimulus	GO:0071560	88	0.060
negative regulation of protein phosphorylation	GO:0001933	126	0.060
lung development	GO:0030324	164	0.059	Mouse
purine ribonucleotide catabolic process	GO:0009154	208	0.059
regulation of ras protein signal transduction	GO:0046578	114	0.059
mammary gland epithelium development	GO:0061180	65	0.059
biomineral tissue development	GO:0031214	64	0.058	Human
bone development	GO:0060348	120	0.058
nucleoside metabolic process	GO:0009116	246	0.058
purine containing compound metabolic process	GO:0072521	311	0.057
cellular response to organonitrogen compound	GO:0071417	145	0.057
developmental cell growth	GO:0048588	84	0.057
central nervous system neuron differentiation	GO:0021953	162	0.057
divalent inorganic cation homeostasis	GO:0072507	138	0.057
single organism nuclear import	GO:1902593	95	0.057
muscle contraction	GO:0006936	101	0.057
neural tube closure	GO:0001843	90	0.057
male gonad development	GO:0008584	88	0.057
innate immune response	GO:0045087	157	0.057
development of primary sexual characteristics	GO:0045137	143	0.056
ribonucleoside metabolic process	GO:0009119	245	0.056
fat cell differentiation	GO:0045444	160	0.056
canonical wnt signaling pathway	GO:0060070	130	0.056
ribonucleoside catabolic process	GO:0042454	206	0.056
embryonic heart tube development	GO:0035050	65	0.056
positive regulation of cell death	GO:0010942	224	0.055
peptidyl threonine phosphorylation	GO:0018107	31	0.055
retina vasculature development in camera type eye	GO:0061298	17	0.055	Mouse
cellular response to hormone stimulus	GO:0032870	150	0.054
transmembrane transport	GO:0055085	412	0.054
regulation of nucleoside metabolic process	GO:0009118	130	0.054
muscle tissue development	GO:0060537	308	0.054
cell substrate adhesion	GO:0031589	130	0.054
positive regulation of map kinase activity	GO:0043406	84	0.054
regulation of leukocyte proliferation	GO:0070663	121	0.054
myeloid cell homeostasis	GO:0002262	114	0.054	Human
smad protein signal transduction	GO:0060395	21	0.053
lymphocyte homeostasis	GO:0002260	64	0.053
regulation of cytoplasmic transport	GO:1903649	112	0.053
regulation of blood circulation	GO:1903522	93	0.053
regulation of epithelial cell proliferation	GO:0050678	141	0.053
immune response regulating signaling pathway	GO:0002764	125	0.053
gtp metabolic process	GO:0046039	144	0.053
regulation of cell size	GO:0008361	72	0.053
positive regulation of lymphocyte activation	GO:0051251	140	0.052
regulation of cell cycle	GO:0051726	281	0.052
regulation of wnt signaling pathway	GO:0030111	123	0.052
memory	GO:0007613	58	0.052
microtubule based process	GO:0007017	236	0.052
regulation of protein catabolic process	GO:0042176	108	0.052
defense response to other organism	GO:0098542	197	0.052
cardiac chamber morphogenesis	GO:0003206	93	0.052
embryonic skeletal system morphogenesis	GO:0048704	91	0.052
leukocyte homeostasis	GO:0001776	79	0.052
regulation of nucleocytoplasmic transport	GO:0046822	73	0.052
regulation of gtp catabolic process	GO:0033124	113	0.051
tolerance induction to self antigen	GO:0002513	4	0.051
olfactory learning	GO:0008355	2	0.051
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	43	0.051
negative regulation of lymphocyte activation	GO:0051250	91	0.051
response to alcohol	GO:0097305	48	0.051
regulation of sequence specific dna binding transcription factor activity	GO:0051090	106	0.050
cellular protein complex assembly	GO:0043623	116	0.050
cellular response to biotic stimulus	GO:0071216	92	0.050
stem cell proliferation	GO:0072089	117	0.050
oogenesis	GO:0048477	56	0.049
phagocytosis	GO:0006909	66	0.049
aromatic compound catabolic process	GO:0019439	286	0.049
alpha beta t cell activation	GO:0046631	91	0.049
negative regulation of defense response	GO:0031348	77	0.049
regulation of ossification	GO:0030278	112	0.049	Human
wound healing	GO:0042060	157	0.049
organelle localization	GO:0051640	179	0.048
gonad development	GO:0008406	141	0.048
lens development in camera type eye	GO:0002088	62	0.048
heart contraction	GO:0060047	93	0.048
negative regulation of bmp signaling pathway	GO:0030514	35	0.048
cardiac chamber development	GO:0003205	108	0.047
positive regulation of jnk cascade	GO:0046330	46	0.047
myeloid leukocyte activation	GO:0002274	83	0.047
mesoderm morphogenesis	GO:0048332	64	0.047
negative regulation of t cell activation	GO:0050868	65	0.047
regulation of map kinase activity	GO:0043405	120	0.047
organophosphate catabolic process	GO:0046434	232	0.047
organic hydroxy compound metabolic process	GO:1901615	203	0.047
cellular response to organic cyclic compound	GO:0071407	87	0.047
male sex differentiation	GO:0046661	109	0.046
nucleoside triphosphate metabolic process	GO:0009141	230	0.046
oocyte axis specification	GO:0007309	2	0.046
purine containing compound catabolic process	GO:0072523	213	0.046
regulation of b cell tolerance induction	GO:0002661	2	0.046
regulation of lymphocyte differentiation	GO:0045619	107	0.046
purine ribonucleotide metabolic process	GO:0009150	290	0.046
macromolecule catabolic process	GO:0009057	281	0.046
chondrocyte differentiation	GO:0002062	72	0.045
negative regulation of cell cycle	GO:0045786	123	0.045
nucleoside catabolic process	GO:0009164	206	0.045
regulation of purine nucleotide catabolic process	GO:0033121	122	0.045
regulation of muscle system process	GO:0090257	80	0.045
rho protein signal transduction	GO:0007266	32	0.045
somite development	GO:0061053	81	0.045
developmental growth involved in morphogenesis	GO:0060560	138	0.045
nucleoside triphosphate catabolic process	GO:0009143	205	0.045
guanosine containing compound catabolic process	GO:1901069	144	0.045
regulation of peptide transport	GO:0090087	91	0.044
multicellular organismal signaling	GO:0035637	91	0.044
positive regulation of hydrolase activity	GO:0051345	148	0.044
immune effector process	GO:0002252	321	0.044
nucleobase containing small molecule metabolic process	GO:0055086	352	0.044
placenta development	GO:0001890	140	0.044
positive regulation of secretion	GO:0051047	130	0.044	Rat
oocyte development	GO:0048599	33	0.044
negative regulation of intracellular signal transduction	GO:1902532	167	0.044
purine nucleoside triphosphate catabolic process	GO:0009146	203	0.044
segmentation	GO:0035282	93	0.044
artery development	GO:0060840	53	0.044	Mouse
regulation of endocytosis	GO:0030100	69	0.044
muscle cell differentiation	GO:0042692	261	0.044
metanephric mesenchyme morphogenesis	GO:0072133	4	0.043
divalent metal ion transport	GO:0070838	172	0.043
kidney mesenchyme morphogenesis	GO:0072131	4	0.043
neural precursor cell proliferation	GO:0061351	121	0.043
regulation of system process	GO:0044057	200	0.043	Rat
blastocyst development	GO:0001824	80	0.043
protein import	GO:0017038	101	0.043
positive regulation of leukocyte differentiation	GO:1902107	86	0.043
immune response activating signal transduction	GO:0002757	116	0.042
regulation of t cell proliferation	GO:0042129	92	0.042
mammary gland duct morphogenesis	GO:0060603	38	0.042
regulation of intracellular protein transport	GO:0033157	82	0.042
cellular lipid metabolic process	GO:0044255	323	0.042
retinal ganglion cell axon guidance	GO:0031290	18	0.042
stress activated protein kinase signaling cascade	GO:0031098	81	0.042
regulation of binding	GO:0051098	111	0.042
negative regulation of apoptotic signaling pathway	GO:2001234	104	0.042
calcium ion homeostasis	GO:0055074	127	0.041
embryonic limb morphogenesis	GO:0030326	126	0.041
photoreceptor cell differentiation	GO:0046530	52	0.041
nephrogenic mesenchyme morphogenesis	GO:0072134	2	0.041
regulation of protein targeting	GO:1903533	61	0.041
response to extracellular stimulus	GO:0009991	127	0.041
endocardial cushion development	GO:0003197	26	0.041
bone mineralization	GO:0030282	54	0.041	Human
learning or memory	GO:0007611	148	0.041
cellular divalent inorganic cation homeostasis	GO:0072503	127	0.041
cell fate commitment	GO:0045165	210	0.041
rhythmic process	GO:0048511	174	0.041
oocyte construction	GO:0007308	2	0.041
actin cytoskeleton organization	GO:0030036	220	0.041
dendrite development	GO:0016358	115	0.041
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry	GO:1900164	2	0.041
regulation of nucleotide catabolic process	GO:0030811	122	0.040
embryonic organ morphogenesis	GO:0048562	276	0.040
development of primary male sexual characteristics	GO:0046546	88	0.040
myotube differentiation	GO:0014902	105	0.040
spermatid development	GO:0007286	108	0.040
positive regulation of protein serine threonine kinase activity	GO:0071902	106	0.040
regulation of purine nucleotide metabolic process	GO:1900542	169	0.040
nucleotide catabolic process	GO:0009166	217	0.040
cell cycle switching mitotic to meiotic cell cycle	GO:0051728	1	0.039
carbohydrate derivative catabolic process	GO:1901136	231	0.039
endodermal cell fate specification	GO:0001714	4	0.039
nephrogenic mesenchyme development	GO:0072076	3	0.039
cardiac ventricle development	GO:0003231	83	0.039
ribonucleotide catabolic process	GO:0009261	208	0.039
protein localization to nucleus	GO:0034504	121	0.039
lung morphogenesis	GO:0060425	50	0.039
gtp catabolic process	GO:0006184	143	0.039
glycosyl compound catabolic process	GO:1901658	206	0.039
protein kinase b signaling	GO:0043491	74	0.038
regulation of rho protein signal transduction	GO:0035023	71	0.038
erk1 and erk2 cascade	GO:0070371	77	0.038
synapse assembly	GO:0007416	56	0.038
dendritic cell differentiation	GO:0097028	26	0.037
regulation of cytoskeleton organization	GO:0051493	122	0.037
cellular calcium ion homeostasis	GO:0006874	119	0.037
regulation of cartilage development	GO:0061035	44	0.037
cell cycle switching	GO:0060184	1	0.037
cellular response to lipopolysaccharide	GO:0071222	77	0.037
regulation of chondrocyte differentiation	GO:0032330	33	0.036
negative regulation of cell development	GO:0010721	169	0.036
regulation of cellular response to stress	GO:0080135	159	0.036
purine ribonucleoside metabolic process	GO:0046128	241	0.036
ribonucleoside triphosphate catabolic process	GO:0009203	199	0.036
regulation of nucleotide metabolic process	GO:0006140	169	0.036
embryonic appendage morphogenesis	GO:0035113	126	0.036
oxidation reduction process	GO:0055114	342	0.036
regulation of stress activated mapk cascade	GO:0032872	69	0.036
insemination	GO:0007320	6	0.036
g protein coupled receptor signaling pathway	GO:0007186	243	0.036
regulation of peptide hormone secretion	GO:0090276	75	0.035
positive regulation of purine nucleotide metabolic process	GO:1900544	114	0.035
nephron development	GO:0072006	109	0.035
liver development	GO:0001889	66	0.035
oocyte differentiation	GO:0009994	35	0.035
divalent inorganic cation transport	GO:0072511	178	0.035
cellular macromolecule catabolic process	GO:0044265	206	0.035
regulation of cellular response to growth factor stimulus	GO:0090287	82	0.035
negative regulation of cell activation	GO:0050866	111	0.035
positive regulation of t cell activation	GO:0050870	101	0.035
purine nucleoside triphosphate metabolic process	GO:0009144	226	0.035
regulation of extent of cell growth	GO:0061387	52	0.035
negative regulation of growth	GO:0045926	99	0.035
protein localization to membrane	GO:0072657	108	0.034
epithelial to mesenchymal transition	GO:0001837	47	0.034
anatomical structure homeostasis	GO:0060249	145	0.034
posttranscriptional regulation of gene expression	GO:0010608	155	0.034
response to nutrient levels	GO:0031667	109	0.034
nephron epithelium development	GO:0072009	92	0.034
regulation of canonical wnt signaling pathway	GO:0060828	82	0.034
transition metal ion homeostasis	GO:0055076	54	0.033
mesonephric epithelium development	GO:0072163	94	0.033
i kappab kinase nf kappab signaling	GO:0007249	85	0.033
b cell homeostasis	GO:0001782	34	0.033
neural crest cell development	GO:0014032	48	0.033	Zebrafish
regulation of ion transmembrane transport	GO:0034765	119	0.033
nucleoside phosphate metabolic process	GO:0006753	338	0.033
purine nucleotide catabolic process	GO:0006195	211	0.033
activation of immune response	GO:0002253	138	0.033
telencephalon development	GO:0021537	186	0.033
inorganic ion transmembrane transport	GO:0098660	234	0.032

Acvr2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease	DO term ID	Probability
physical disorder	DOID:0080015	0.056
disease of cellular proliferation	DOID:14566	0.036
cancer	DOID:162	0.033
organ system cancer	DOID:0050686	0.033

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