Mus musculus

0 known processes

Spg21

spastic paraplegia 21 homolog (human)

(Aliases: D9Wsu18e,MAST,GL010,BM-019,C78576,ACP33)

Spg21 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of peptidase activityGO:0010952490.212
regulation of hydrolase activityGO:00513362460.173
regulation of apoptotic signaling pathwayGO:20012331970.101
cellular protein catabolic processGO:00442571550.097
regulation of peptidase activityGO:0052547960.093
carbohydrate derivative catabolic processGO:19011362310.090
apoptotic signaling pathwayGO:00971903060.082
positive regulation of hydrolase activityGO:00513451480.081
regulation of organelle organizationGO:00330432890.081
purine ribonucleoside metabolic processGO:00461282410.080
organophosphate catabolic processGO:00464342320.072
heterocycle catabolic processGO:00467002800.071
zymogen activationGO:0031638410.069
positive regulation of proteolysisGO:0045862850.068
homeostasis of number of cellsGO:00488722100.067
small gtpase mediated signal transductionGO:0007264970.065
positive regulation of cell deathGO:00109422240.064
positive regulation of cell cycleGO:0045787920.063
epithelial tube morphogenesisGO:00605623030.063
positive regulation of programmed cell deathGO:00430682180.061
regulation of proteolysisGO:00301621640.060
blood vessel morphogenesisGO:00485142850.056
ras protein signal transductionGO:0007265770.054
purine nucleotide metabolic processGO:00061633020.052
positive regulation of apoptotic signaling pathwayGO:2001235950.052
regulation of homeostatic processGO:00328441820.051
positive regulation of endopeptidase activityGO:0010950430.050
regulation of cellular amino acid metabolic processGO:000652150.049
maintenance of locationGO:0051235890.049
regulation of protein localizationGO:00328802310.049
embryonic epithelial tube formationGO:00018381300.048
cellular ketone metabolic processGO:0042180840.048
nucleoside phosphate metabolic processGO:00067533380.048
cation homeostasisGO:00550802120.047
purine ribonucleoside triphosphate catabolic processGO:00092071990.047
ribonucleoside metabolic processGO:00091192450.047
cellular amino acid metabolic processGO:00065201030.046
cytoplasmic transportGO:00164822340.046
purine nucleoside catabolic processGO:00061522050.045
cellular nitrogen compound catabolic processGO:00442702800.045
negative regulation of homeostatic processGO:0032845710.045
regulation of cellular ketone metabolic processGO:0010565660.044
negative regulation of protein metabolic processGO:00512482820.043
regulation of cell cycleGO:00517262810.043
immune effector processGO:00022523210.043
sequestering of metal ionGO:0051238190.041
glycosyl compound catabolic processGO:19016582060.041
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathwayGO:004316230.040
purine ribonucleotide catabolic processGO:00091542080.040
nitrogen compound transportGO:00717052710.040
divalent metal ion transportGO:00708381720.040
negative regulation of molecular functionGO:00440922580.040
protein processingGO:00164851630.040
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280360.040
nucleotide catabolic processGO:00091662170.040
cation transportGO:00068123990.039
nucleobase containing small molecule metabolic processGO:00550863520.039
negative regulation of cellular protein metabolic processGO:00322692470.039
regulation of cellular amine metabolic processGO:0033238200.039
ribonucleoside catabolic processGO:00424542060.039
negative regulation of neuron deathGO:1901215980.037
regulation of endopeptidase activityGO:0052548890.037
activation of cysteine type endopeptidase activityGO:0097202270.036
oxidation reduction processGO:00551143420.036
regulation of anatomical structure sizeGO:00900661780.036
intracellular protein transportGO:00068862040.036
protein catabolic processGO:00301632210.035
nucleoside triphosphate catabolic processGO:00091432050.035
respiratory system developmentGO:00605411900.035
positive regulation of secretionGO:00510471300.035
membrane organizationGO:00610242450.034
cellular response to dna damage stimulusGO:00069742070.034
phagosome maturationGO:009038240.034
organelle fissionGO:00482851700.034
positive regulation of apoptotic processGO:00430652170.034
meiotic cell cycleGO:00513211220.034
nucleoside catabolic processGO:00091642060.033
protein ubiquitinationGO:00165671710.033
aromatic compound catabolic processGO:00194392860.033
cell type specific apoptotic processGO:00972852680.033
protein localization to organelleGO:00333651850.033
negative regulation of organelle organizationGO:0010639900.033
cellular chemical homeostasisGO:00550822150.032
ribonucleotide metabolic processGO:00092592910.032
regulation of transferase activityGO:00513382630.032
negative regulation of cellular component organizationGO:00511291940.031
angiogenesisGO:00015252010.031
cell divisionGO:00513011200.031
positive regulation of cell developmentGO:00107202370.031
ribonucleoside triphosphate catabolic processGO:00092031990.031
carbohydrate derivative biosynthetic processGO:19011371830.030
regulation of cellular component biogenesisGO:00440871810.030
organic cyclic compound catabolic processGO:19013612950.030
endocytosisGO:00068971680.030
regulation of protein transportGO:00512231630.030
carbohydrate metabolic processGO:00059752300.029
cellular calcium ion homeostasisGO:00068741190.029
regulation of secretionGO:00510462740.029
arp2 3 complex mediated actin nucleationGO:003431430.029
protein maturationGO:00516041760.029
muscle cell differentiationGO:00426922610.029
extrinsic apoptotic signaling pathwayGO:00971911260.029
macromolecule catabolic processGO:00090572810.029
positive regulation of cysteine type endopeptidase activityGO:2001056390.029
regulation of system processGO:00440572000.029
sequestering of calcium ionGO:0051208180.029
pigment accumulationGO:004347610.029
protein modification by small protein conjugationGO:00324461870.029
regulation of cysteine type endopeptidase activityGO:2000116650.028
calcium ion transportGO:00068161590.028
ribose phosphate metabolic processGO:00196932910.027
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281620.027
regulation of cell motilityGO:20001452360.027
purine nucleotide catabolic processGO:00061952110.027
regulation of neuron deathGO:19012141340.027
protein targetingGO:00066051430.026
neuron apoptotic processGO:00514021420.026
nucleoside metabolic processGO:00091162460.026
leukocyte apoptotic processGO:0071887710.026
regulation of plasminogen activationGO:001075540.026
negative regulation of cell proliferationGO:00082852960.026
endomembrane system organizationGO:00102561470.026
regulation of neuron differentiationGO:00456642810.026
regulation of lymphocyte activationGO:00512492400.026
divalent inorganic cation transportGO:00725111780.026
nucleotide metabolic processGO:00091173320.026
adaptive immune responseGO:00022501550.026
regulation of cell projection organizationGO:00313442060.025
epithelial tube formationGO:00721751300.025
cellular homeostasisGO:00197252400.025
striated muscle tissue developmentGO:00147062930.025
t cell activationGO:00421102890.025
purine nucleoside triphosphate metabolic processGO:00091442260.025
glycosyl compound metabolic processGO:19016572460.024
purine containing compound catabolic processGO:00725232130.024
positive regulation of neuron differentiationGO:00456661410.024
morphogenesis of a branching epitheliumGO:00611381930.024
regulation of hormone levelsGO:00108172110.024
neural tube formationGO:00018411080.023
cellular macromolecule catabolic processGO:00442652060.023
multicellular organismal signalingGO:0035637910.023
phagolysosome assemblyGO:000184530.023
purine nucleoside triphosphate catabolic processGO:00091462030.023
regulation of establishment of protein localizationGO:00702011810.023
leukocyte homeostasisGO:0001776790.023
regulation of cell activationGO:00508652890.023
regulation of calcium ion transport into cytosolGO:0010522310.023
negative regulation of phosphorus metabolic processGO:00105631840.023
negative regulation of neuron apoptotic processGO:0043524920.023
nuclear transportGO:00511691390.023
cellular protein complex assemblyGO:00436231160.023
cellular amine metabolic processGO:0044106440.023
regulation of cellular catabolic processGO:00313292420.023
lymphocyte homeostasisGO:0002260640.023
muscle tissue developmentGO:00605373080.022
response to monosaccharideGO:0034284670.022
regulation of muscle contractionGO:0006937490.022
purine nucleoside metabolic processGO:00422782410.022
nucleoside triphosphate metabolic processGO:00091412300.022
microtubule based processGO:00070172360.022
proteolysis involved in cellular protein catabolic processGO:00516031470.022
myeloid cell differentiationGO:00300992330.022
gtp metabolic processGO:00460391440.022
regulation of neuron apoptotic processGO:00435231220.022
metal ion homeostasisGO:00550651890.022
purine containing compound metabolic processGO:00725213110.022
wound healingGO:00420601570.021
regulation of cytoplasmic transportGO:19036491120.021
multicellular organism growthGO:00352641610.021
myeloid cell homeostasisGO:00022621140.021
positive regulation of nervous system developmentGO:00519622210.021
neuron deathGO:00709971540.021
ion transmembrane transportGO:00342203610.021
cation transmembrane transportGO:00986552660.021
purine ribonucleoside catabolic processGO:00461302050.021
positive regulation of growthGO:00459271040.021
retrograde transport endosome to golgiGO:004214720.021
regulation of interleukin 8 productionGO:003267730.021
regulation of nucleocytoplasmic transportGO:0046822730.021
purine ribonucleoside triphosphate metabolic processGO:00092052200.021
establishment of protein localization to organelleGO:00725941180.020
peptide transportGO:00158331330.020
amide transportGO:00428861380.020
mitotic cell cycleGO:00002781950.020
regulation of t cell activationGO:00508631700.020
cell adhesionGO:00071553290.020
regulation of response to woundingGO:19030341890.020
regulation of protein serine threonine kinase activityGO:00719001570.020
respiratory tube developmentGO:00303231670.020
positive regulation of cellular catabolic processGO:00313311480.020
myotube differentiationGO:00149021050.020
cellular metal ion homeostasisGO:00068751510.020
ribonucleoside triphosphate metabolic processGO:00091992200.020
leukocyte mediated immunityGO:00024431740.019
carboxylic acid catabolic processGO:0046395510.019
regulation of secretion by cellGO:19035302490.019
regulation of actin filament polymerizationGO:0030833380.019
organonitrogen compound catabolic processGO:19015652640.019
lung developmentGO:00303241640.019
regulation of vesicle mediated transportGO:00606271390.019
sensory organ morphogenesisGO:00905962420.019
activation of cysteine type endopeptidase activity involved in apoptotic processGO:0006919270.019
positive regulation of cellular amino acid metabolic processGO:004576430.019
positive regulation of cell projection organizationGO:0031346950.019
mapk cascadeGO:00001652810.019
skeletal muscle organ developmentGO:00605381630.019
neural tube developmentGO:00219151600.019
negative regulation of immune system processGO:00026832090.019
vesicle organizationGO:0016050600.019
spermatogenesisGO:00072832840.019
lymphocyte differentiationGO:00300982420.019
purine ribonucleotide metabolic processGO:00091502900.019
negative regulation of apoptotic signaling pathwayGO:20012341040.018
leukocyte differentiationGO:00025213420.018
negative regulation of phosphate metabolic processGO:00459361840.018
ameboidal type cell migrationGO:00016671280.018
protein localization to nucleusGO:00345041210.018
amine metabolic processGO:0009308450.018
regulation of interleukin 1 alpha productionGO:003265040.018
nucleocytoplasmic transportGO:00069131390.018
protein modification by small protein conjugation or removalGO:00706472070.018
positive regulation of cellular amine metabolic processGO:003324050.018
g protein coupled receptor signaling pathwayGO:00071862430.018
monosaccharide metabolic processGO:00059961060.018
negative regulation of intracellular signal transductionGO:19025321670.018
regulation of cell morphogenesis involved in differentiationGO:00107691510.018
regulation of protein complex assemblyGO:0043254830.018
regulation of cell cycle processGO:00105641600.017
activation of adenylate cyclase activityGO:000719040.017
negative regulation of protein modification processGO:00314001630.017
regulation of lymphocyte proliferationGO:00506701170.017
negative regulation of nervous system developmentGO:00519611560.017
protein oligomerizationGO:0051259670.017
gtp catabolic processGO:00061841430.017
multi multicellular organism processGO:00447061090.017
regulation of membrane potentialGO:00423911920.017
sensory perceptionGO:00076002450.017
regulation of cellular component sizeGO:00325351210.017
regulation of epithelial cell proliferationGO:00506781410.017
circulatory system processGO:00030131970.017
peptide hormone secretionGO:00300721090.017
dna metabolic processGO:00062593030.017
rhythmic processGO:00485111740.017
tube formationGO:00351481400.017
divalent inorganic cation homeostasisGO:00725071380.017
cellular response to cytokine stimulusGO:00713451890.017
positive regulation of secretion by cellGO:19035321140.016
regulation of mitotic cell cycleGO:00073461260.016
blood circulationGO:00080151950.016
lymphocyte proliferationGO:00466511640.016
organic hydroxy compound metabolic processGO:19016152030.016
positive regulation of interleukin 1 alpha productionGO:003273040.016
muscle contractionGO:00069361010.016
male gamete generationGO:00482322850.016
calcium ion homeostasisGO:00550741270.016
regulation of intracellular transportGO:00323861590.016
regulation of cell growthGO:0001558910.016
organelle fusionGO:0048284280.016
heart morphogenesisGO:00030071780.016
negative regulation of cellular amino acid metabolic processGO:004576300.016
regulation of ion transportGO:00432692150.016
regulation of cytokine productionGO:00018172660.016
cilium morphogenesisGO:00602711020.015
lung morphogenesisGO:0060425500.015
apoptotic mitochondrial changesGO:0008637480.015
inorganic cation transmembrane transportGO:00986622070.015
vasodilationGO:0042311280.015
epithelial cell proliferationGO:00506731740.015
regulation of sequence specific dna binding transcription factor activityGO:00510901060.015
morphogenesis of a branching structureGO:00017632030.015
positive regulation of cellular component biogenesisGO:0044089940.015
peptide secretionGO:00027901140.015
barbed end actin filament cappingGO:005101660.015
regulation of protein catabolic processGO:00421761080.015
modification dependent macromolecule catabolic processGO:00436321330.015
release of sequestered calcium ion into cytosolGO:0051209420.015
regulation of inflammatory responseGO:00507271470.015
cell growthGO:00160491300.015
guanosine containing compound metabolic processGO:19010681440.015
positive regulation of cell adhesionGO:0045785800.015
glucose homeostasisGO:00425931280.015
positive regulation of nucleotide metabolic processGO:00459811140.015
negative regulation of sequence specific dna binding transcription factor activityGO:0043433400.015
regulation of metal ion transportGO:00109591060.015
regulation of protein maturationGO:1903317960.015
morphogenesis of embryonic epitheliumGO:00163311590.014
positive regulation of protein modification processGO:00314012990.014
interleukin 1 alpha secretionGO:005070330.014
positive regulation of plasminogen activationGO:001075620.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.014
t cell proliferationGO:00420981200.014
cellular lipid metabolic processGO:00442553230.014
regulation of calcium ion transportGO:0051924690.014
positive regulation of interleukin 1 secretionGO:0050716140.014
engulfment of apoptotic cellGO:004365230.014
embryonic organ morphogenesisGO:00485622760.014
transmission of nerve impulseGO:0019226760.014
glial cell apoptotic processGO:003434930.014
synapse organizationGO:00508081250.014
regulation of interleukin 1 alpha secretionGO:005070530.014
regulation of synaptic growth at neuromuscular junctionGO:000858240.014
positive regulation of cell migrationGO:00303351090.014
regulation of t cell proliferationGO:0042129920.014
transmembrane transportGO:00550854120.014
cellular divalent inorganic cation homeostasisGO:00725031270.014
regulation of protein kinase activityGO:00458592320.014
mitotic cell cycle processGO:19030471590.014
regulation of neuron projection developmentGO:00109751690.013
regulation of mapk cascadeGO:00434082480.013
cytosolic calcium ion transportGO:0060401480.013
positive regulation of mapk cascadeGO:00434101700.013
positive regulation of cell growthGO:0030307330.013
response to inorganic substanceGO:0010035960.013
guanosine containing compound catabolic processGO:19010691440.013
branching morphogenesis of an epithelial tubeGO:00487541590.013
regulation of cell cycle phase transitionGO:1901987770.013
wnt signaling pathwayGO:00160551880.013
heart processGO:0003015940.013
regulation of cell substrate adhesionGO:0010810730.013
calcium ion transport into cytosolGO:0060402480.013
phagocytosisGO:0006909660.013
regionalizationGO:00030023370.013
lytic vacuole organizationGO:0080171210.013
nuclear divisionGO:00002801580.013
positive regulation of protein kinase activityGO:00458601440.013
vacuole organizationGO:0007033380.013
regulation of kinase activityGO:00435492490.013
positive regulation of cytosolic calcium ion concentrationGO:0007204650.013
regulation of leukocyte apoptotic processGO:2000106560.013
positive regulation of protein serine threonine kinase activityGO:00719021060.013
cellular ion homeostasisGO:00068731650.013
locomotory behaviorGO:00076261950.013
small molecule catabolic processGO:0044282710.013
positive regulation of mitotic cell cycleGO:0045931410.013
response to molecule of bacterial originGO:00022371430.013
epidermis developmentGO:00085441870.013
positive regulation of kinase activityGO:00336741550.013
heart contractionGO:0060047930.013
positive regulation of lymphocyte activationGO:00512511400.013
positive regulation of cell activationGO:00508671580.013
ceramide metabolic processGO:0006672310.012
erythrocyte differentiationGO:0030218880.012
ossificationGO:00015032160.012
axonogenesisGO:00074092740.012
protein targeting to vacuoleGO:000662330.012
anatomical structure homeostasisGO:00602491450.012
germ cell developmentGO:00072811850.012
cellular response to monosaccharide stimulusGO:0071326470.012
neuronal action potentialGO:0019228540.012
regulation of protein modification by small protein conjugation or removalGO:1903320570.012
positive regulation of homeostatic processGO:0032846640.012
organic hydroxy compound transportGO:0015850930.012
positive regulation of purine nucleotide metabolic processGO:19005441140.012
inter male aggressive behaviorGO:000212130.012
regulation of cell adhesionGO:00301551540.012
positive regulation of protein phosphorylationGO:00019342420.012
negative regulation of osteoblast proliferationGO:003368940.012
digestive system developmentGO:00551232000.012
regulation of vascular smooth muscle contractionGO:000305610.012
digestive tract developmentGO:00485651900.012
negative regulation of cellular amine metabolic processGO:003323910.012
neural tube closureGO:0001843900.012
protein importGO:00170381010.012
skin developmentGO:00435882200.012
dephosphorylationGO:00163111290.012
regulation of cytoskeleton organizationGO:00514931220.012
cytosolic calcium ion homeostasisGO:0051480700.011
positive regulation of cell cycle processGO:0090068610.011
regulation of actin cytoskeleton organizationGO:0032956840.011
developmental maturationGO:00217001930.011
ribonucleotide catabolic processGO:00092612080.011
regulation of nucleotide metabolic processGO:00061401690.011
cellular glucose homeostasisGO:0001678520.011
protein import into nucleusGO:0006606950.011
positive regulation of cytokine productionGO:00018191740.011
cellular response to glucose stimulusGO:0071333450.011
cellular response to hexose stimulusGO:0071331470.011
hormone secretionGO:00468791280.011
organic acid transportGO:00158491010.011
cytokine productionGO:00018163190.011
ribonucleotide biosynthetic processGO:0009260590.011
protein localization to vacuoleGO:007266540.011
regulation of ossificationGO:00302781120.011
regulation of nucleotide catabolic processGO:00308111220.011
terminal button organizationGO:007255330.011
response to organonitrogen compoundGO:00102432460.011
bundle of his developmentGO:000316640.011
carbohydrate homeostasisGO:00335001280.011
mesonephros developmentGO:0001823970.011
muscle fiber developmentGO:0048747760.011
regulation of muscle tissue developmentGO:1901861970.011
regulation of muscle system processGO:0090257800.011
regulation of protein processingGO:0070613960.011
asymmetric neuroblast divisionGO:005505910.011
regulation of cell migrationGO:00303342190.011
regulation of arp2 3 complex mediated actin nucleationGO:003431510.011
membrane fusionGO:0061025380.011
negative regulation of growthGO:0045926990.011
regulation of ion homeostasisGO:2000021640.011
protein polymerizationGO:0051258570.011
regulation of leukocyte proliferationGO:00706631210.011
mitochondrion organizationGO:00070051340.011
organism emergence from protective structureGO:007168440.011
regulation of protein secretionGO:0050708820.011
positive regulation of organelle organizationGO:00106381280.011
negative regulation of cell cycleGO:00457861230.011
proteasomal protein catabolic processGO:0010498980.011
insulin secretionGO:0030073890.011
skeletal muscle fiber developmentGO:0048741580.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:00900921120.010
negative regulation of phosphorylationGO:00423261660.010
membrane depolarizationGO:0051899640.010
lateral inhibitionGO:004633110.010
regulation of cellular response to growth factor stimulusGO:0090287820.010
regulation of bindingGO:00510981110.010
positive regulation of intracellular transportGO:0032388700.010
regulation of blood circulationGO:1903522930.010
cytokine secretionGO:0050663720.010
regulation of neurotransmitter levelsGO:0001505870.010
lateral line system developmentGO:004892510.010
pigmentationGO:0043473710.010
negative regulation of response to woundingGO:1903035770.010
organonitrogen compound biosynthetic processGO:19015661920.010
regulation of purine nucleotide metabolic processGO:19005421690.010
leukocyte proliferationGO:00706611720.010
cellular component assembly involved in morphogenesisGO:00109271390.010
bone developmentGO:00603481200.010
sensory system developmentGO:004888030.010
hatchingGO:003518840.010
skeletal system developmentGO:00015013560.010

Spg21 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.031
nervous system diseaseDOID:86300.031
disease of cellular proliferationDOID:1456600.017
connective tissue diseaseDOID:6500.017
musculoskeletal system diseaseDOID:1700.017
bone diseaseDOID:008000100.015
inherited metabolic disorderDOID:65500.015
disease of metabolismDOID:001466700.015
cancerDOID:16200.014
central nervous system diseaseDOID:33100.012
intestinal cancerDOID:1015500.011
gastrointestinal system cancerDOID:311900.011
organ system cancerDOID:005068600.011
large intestine cancerDOID:567200.011