Mus musculus

164 known processes

Nkx6-2

NK6 homeobox 2

(Aliases: Gtx,Nkx6.2)

Nkx6-2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of cell developmentGO:00107211690.160
blood vessel morphogenesisGO:00485142850.159
cation transportGO:00068123990.142
rho protein signal transductionGO:0007266320.131
cell type specific apoptotic processGO:00972852680.107
regulation of cellular amino acid metabolic processGO:000652150.104
ion transmembrane transportGO:00342203610.090
transmembrane transportGO:00550854120.089
negative regulation of neuron differentiationGO:00456651010.087
morphogenesis of a branching structureGO:00017632030.087
negative regulation of cellular amino acid metabolic processGO:004576300.083
negative regulation of neuron deathGO:1901215980.081
small gtpase mediated signal transductionGO:0007264970.080
negative regulation of phosphorylationGO:00423261660.076
immune effector processGO:00022523210.075
cellular lipid metabolic processGO:00442553230.073
regulation of neuron differentiationGO:00456642810.070
Mouse
negative regulation of molecular functionGO:00440922580.066
nitrogen compound transportGO:00717052710.065
stem cell differentiationGO:00488632680.065
response to oxidative stressGO:00069791230.060
innervationGO:0060384220.058
ribonucleoside metabolic processGO:00091192450.058
epithelial tube morphogenesisGO:00605623030.058
regulation of ion transportGO:00432692150.058
regulation of cellular component sizeGO:00325351210.057
Mouse
cation transmembrane transportGO:00986552660.057
myeloid cell differentiationGO:00300992330.057
regulation of ion homeostasisGO:2000021640.057
regulation of membrane potentialGO:00423911920.053
leukocyte mediated immunityGO:00024431740.053
response to organonitrogen compoundGO:00102432460.052
morphogenesis of a branching epitheliumGO:00611381930.052
gtp catabolic processGO:00061841430.052
forebrain developmentGO:00309003020.051
alpha beta t cell differentiationGO:0046632690.051
cellular amino acid metabolic processGO:00065201030.050
regulation of leukocyte mediated immunityGO:00027031040.050
cellular amine metabolic processGO:0044106440.049
positive regulation of cell developmentGO:00107202370.047
negative regulation of cellular amine metabolic processGO:003323910.047
amine metabolic processGO:0009308450.045
embryonic epithelial tube formationGO:00018381300.045
regulation of neuron deathGO:19012141340.044
negative regulation of neuron apoptotic processGO:0043524920.044
purine ribonucleotide catabolic processGO:00091542080.044
nephron tubule developmentGO:0072080840.044
sequestering of calcium ionGO:0051208180.043
response to acid chemicalGO:00011011110.043
negative regulation of protein metabolic processGO:00512482820.043
lymphocyte differentiationGO:00300982420.042
response to peptideGO:19016521360.042
regulation of cell projection organizationGO:00313442060.042
Mouse
tube formationGO:00351481400.040
epithelial tube formationGO:00721751300.040
regulation of intracellular transportGO:00323861590.039
nucleoside metabolic processGO:00091162460.039
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.039
neuron deathGO:00709971540.039
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.038
directional locomotionGO:003305830.038
aromatic compound catabolic processGO:00194392860.038
associative learningGO:0008306610.038
regulation of hydrolase activityGO:00513362460.037
single fertilizationGO:0007338820.037
peptide transportGO:00158331330.037
rac protein signal transductionGO:0016601130.037
ras protein signal transductionGO:0007265770.037
cognitionGO:00508901490.037
cellular ketone metabolic processGO:0042180840.037
b cell activationGO:00421131610.036
lymphocyte mediated immunityGO:00024491390.036
positive regulation of cellular amino acid metabolic processGO:004576430.036
skin developmentGO:00435882200.035
cytoplasmic transportGO:00164822340.035
positive regulation of cellular component biogenesisGO:0044089940.035
protein processingGO:00164851630.035
positive regulation of immune effector processGO:00026991070.035
regulation of system processGO:00440572000.035
cardiac ventricle developmentGO:0003231830.034
learningGO:0007612980.034
regulation of cellular amine metabolic processGO:0033238200.034
neuronal action potentialGO:0019228540.034
olfactory learningGO:000835520.034
muscle cell differentiationGO:00426922610.034
organelle localizationGO:00516401790.033
inorganic ion transmembrane transportGO:00986602340.033
nucleoside phosphate metabolic processGO:00067533380.033
exocytosisGO:00068871210.032
axonogenesisGO:00074092740.032
Mouse
positive regulation of cell deathGO:00109422240.032
gtp metabolic processGO:00460391440.032
peripheral nervous system developmentGO:0007422530.032
cd4 positive alpha beta t cell activationGO:0035710450.031
positive regulation of programmed cell deathGO:00430682180.031
columnar cuboidal epithelial cell differentiationGO:0002065820.031
Zebrafish Mouse
stem cell developmentGO:00488642190.031
positive regulation of nucleotide catabolic processGO:0030813880.031
cell recognitionGO:0008037830.031
divalent inorganic cation homeostasisGO:00725071380.030
muscle tissue developmentGO:00605373080.030
purine containing compound catabolic processGO:00725232130.030
regulation of cytokine productionGO:00018172660.030
t cell differentiationGO:00302171740.029
divalent metal ion transportGO:00708381720.029
autonomic nervous system developmentGO:0048483430.029
regionalizationGO:00030023370.028
regulation of ras gtpase activityGO:0032318880.028
wnt signaling pathwayGO:00160551880.028
purine nucleoside triphosphate metabolic processGO:00091442260.028
cellular response to growth factor stimulusGO:00713631970.028
cellular response to organonitrogen compoundGO:00714171450.028
regulation of gtp catabolic processGO:00331241130.028
cd4 positive alpha beta t cell differentiationGO:0043367410.028
regulation of nucleoside metabolic processGO:00091181300.028
development of primary sexual characteristicsGO:00451371430.028
Worm
glycosyl compound metabolic processGO:19016572460.027
negative regulation of cellular protein metabolic processGO:00322692470.027
membrane lipid metabolic processGO:0006643530.027
g protein coupled receptor signaling pathwayGO:00071862430.027
negative regulation of protein modification processGO:00314001630.026
purine nucleoside triphosphate catabolic processGO:00091462030.026
ribonucleoside triphosphate catabolic processGO:00092031990.026
regulation of nucleotide catabolic processGO:00308111220.026
regulation of lymphocyte mediated immunityGO:0002706840.026
midgut developmentGO:000749440.026
anion transportGO:00068201770.025
nucleoside phosphate catabolic processGO:19012922220.025
cell maturationGO:00484691270.025
homeostasis of number of cellsGO:00488722100.025
synaptic transmissionGO:00072683290.025
neural tube developmentGO:00219151600.025
negative regulation of phosphorus metabolic processGO:00105631840.025
modification dependent macromolecule catabolic processGO:00436321330.025
organic cyclic compound catabolic processGO:19013612950.025
neuron apoptotic processGO:00514021420.025
nucleobase containing small molecule metabolic processGO:00550863520.025
dendrite developmentGO:00163581150.025
glycoprotein metabolic processGO:00091001160.025
organonitrogen compound catabolic processGO:19015652640.024
positive regulation of apoptotic processGO:00430652170.024
cell cell recognitionGO:0009988440.024
reactive nitrogen species metabolic processGO:200105700.024
organophosphate catabolic processGO:00464342320.024
cytokine productionGO:00018163190.024
cellular ion homeostasisGO:00068731650.024
response to inorganic substanceGO:0010035960.024
angiogenesisGO:00015252010.024
regulation of canonical wnt signaling pathwayGO:0060828820.023
regulation of cellular ketone metabolic processGO:0010565660.023
sequestering of metal ionGO:0051238190.023
skeletal system developmentGO:00015013560.023
spermatogenesisGO:00072832840.023
cellular nitrogen compound catabolic processGO:00442702800.023
single organismal cell cell adhesionGO:00163371310.023
leukocyte differentiationGO:00025213420.023
inflammatory responseGO:00069542440.023
purine containing compound metabolic processGO:00725213110.023
camera type eye developmentGO:00430102660.022
glycerolipid metabolic processGO:00464861220.022
negative regulation of protein phosphorylationGO:00019331260.022
circulatory system processGO:00030131970.022
renal tubule developmentGO:0061326870.022
positive regulation of gtpase activityGO:0043547850.022
ossificationGO:00015032160.022
multicellular organismal response to stressGO:0033555620.022
chromatin modificationGO:00165681870.022
transmission of nerve impulseGO:0019226760.021
b cell differentiationGO:0030183780.021
negative regulation of phosphate metabolic processGO:00459361840.021
liver developmentGO:0001889660.021
organic hydroxy compound metabolic processGO:19016152030.021
regulation of secretion by cellGO:19035302490.021
guanosine containing compound catabolic processGO:19010691440.021
negative regulation of cellular component organizationGO:00511291940.021
sensory perception of painGO:0019233470.021
regulation of organelle organizationGO:00330432890.021
cell adhesionGO:00071553290.021
protein catabolic processGO:00301632210.020
regulation of rho protein signal transductionGO:0035023710.020
epithelial cell proliferationGO:00506731740.020
positive regulation of cell projection organizationGO:0031346950.020
purine nucleotide catabolic processGO:00061952110.020
t cell mediated immunityGO:0002456500.020
carbohydrate derivative catabolic processGO:19011362310.020
positive regulation of nervous system developmentGO:00519622210.020
t cell activationGO:00421102890.020
actin filament organizationGO:00070151130.020
cardiac chamber morphogenesisGO:0003206930.020
membrane organizationGO:00610242450.020
protein maturationGO:00516041760.020
response to growth factorGO:00708481980.020
kidney epithelium developmentGO:00720731210.020
purine nucleoside metabolic processGO:00422782410.020
sensory perceptionGO:00076002450.019
hepaticobiliary system developmentGO:0061008670.019
positive regulation of cell morphogenesis involved in differentiationGO:0010770720.019
cardiac muscle contractionGO:0060048320.019
heart morphogenesisGO:00030071780.019
tube closureGO:0060606910.019
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071692470.019
cellular chemical homeostasisGO:00550822150.019
neural tube formationGO:00018411080.019
developmental maturationGO:00217001930.019
regulation of rho gtpase activityGO:0032319580.019
positive regulation of purine nucleotide catabolic processGO:0033123880.019
reactive oxygen species metabolic processGO:0072593840.019
negative regulation of intracellular signal transductionGO:19025321670.019
glycosyl compound catabolic processGO:19016582060.019
positive regulation of smooth muscle cell migrationGO:001491140.019
regulation of neuron apoptotic processGO:00435231220.018
learning or memoryGO:00076111480.018
negative regulation of immune system processGO:00026832090.018
cytosolic calcium ion homeostasisGO:0051480700.018
neuromuscular processGO:0050905990.018
cofactor metabolic processGO:0051186800.018
ribonucleoside catabolic processGO:00424542060.018
apoptotic signaling pathwayGO:00971903060.018
phospholipid metabolic processGO:0006644870.018
cellular response to peptide hormone stimulusGO:0071375920.018
regulation of cellular catabolic processGO:00313292420.018
hypothalamus developmentGO:0021854160.018
heart contractionGO:0060047930.018
cellular response to acid chemicalGO:0071229680.018
leukocyte activation involved in immune responseGO:00023661260.018
protein modification by small protein conjugationGO:00324461870.018
nerve developmentGO:0021675670.018
regulation of cell migrationGO:00303342190.018
Mouse
carbohydrate metabolic processGO:00059752300.018
inorganic cation transmembrane transportGO:00986622070.018
gland developmentGO:00487323300.018
inorganic anion transportGO:0015698430.017
striated muscle tissue developmentGO:00147062930.017
negative regulation of nervous system developmentGO:00519611560.017
positive regulation of cell migrationGO:00303351090.017
regulation of protein localizationGO:00328802310.017
regulation of kinase activityGO:00435492490.017
cell activation involved in immune responseGO:00022631260.017
pancreatic pp cell fate commitmentGO:000332920.017
telencephalon developmentGO:00215371860.017
positive regulation of gtp catabolic processGO:0033126850.017
positive regulation of cellular amine metabolic processGO:003324050.017
proteasomal protein catabolic processGO:0010498980.017
regulation of vasculature developmentGO:1901342880.017
ribose phosphate metabolic processGO:00196932910.017
carbohydrate derivative biosynthetic processGO:19011371830.017
circadian rhythmGO:00076231140.017
regulation of purine nucleotide catabolic processGO:00331211220.017
developmental growth involved in morphogenesisGO:00605601380.016
Mouse
actin cytoskeleton organizationGO:00300362200.016
alpha beta t cell activationGO:0046631910.016
morphogenesis of embryonic epitheliumGO:00163311590.016
ear developmentGO:00435832000.016
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.016
neuron projection guidanceGO:00974851410.016
phosphatidylethanolamine biosynthetic processGO:000664620.016
regulation of synaptic plasticityGO:0048167870.016
maintenance of locationGO:0051235890.016
mechanoreceptor differentiationGO:0042490670.016
cerebral cortex developmentGO:0021987860.016
organonitrogen compound biosynthetic processGO:19015661920.016
positive regulation of phospholipase activityGO:001051830.016
protein localization to membraneGO:00726571080.016
negative regulation of neuron projection developmentGO:0010977500.016
regulation of cytoplasmic transportGO:19036491120.016
purine nucleotide metabolic processGO:00061633020.016
purine ribonucleoside triphosphate metabolic processGO:00092052200.016
leukocyte proliferationGO:00706611720.016
purine ribonucleoside metabolic processGO:00461282410.016
regulation of angiogenesisGO:0045765810.016
ceramide metabolic processGO:0006672310.015
purine ribonucleoside triphosphate catabolic processGO:00092071990.015
positive regulation of cytokine productionGO:00018191740.015
negative regulation of smooth muscle cell migrationGO:001491220.015
cellular homeostasisGO:00197252400.015
sphingolipid metabolic processGO:0006665450.015
regulation of bindingGO:00510981110.015
negative regulation of cell migrationGO:0030336590.015
ribonucleotide catabolic processGO:00092612080.015
regulation of adaptive immune responseGO:0002819900.015
adult locomotory behaviorGO:0008344910.015
negative regulation of phagocytosisGO:005076540.015
positive regulation of leukocyte mediated immunityGO:0002705700.015
substantia nigra developmentGO:002176220.015
regulation of cell motilityGO:20001452360.015
Mouse
binding of sperm to zona pellucidaGO:0007339340.015
purine ribonucleoside catabolic processGO:00461302050.015
regulation of neuron projection developmentGO:00109751690.015
Mouse
regulation of purine nucleotide metabolic processGO:19005421690.015
amide transportGO:00428861380.015
leukocyte homeostasisGO:0001776790.015
steroid metabolic processGO:00082021190.015
glucose homeostasisGO:00425931280.015
positive regulation of nucleotide metabolic processGO:00459811140.015
ribonucleoside triphosphate metabolic processGO:00091992200.015
regulation of gliogenesisGO:0014013500.015
regulation of sequence specific dna binding transcription factor activityGO:00510901060.014
regulation of cell cycleGO:00517262810.014
cardiac septum developmentGO:0003279590.014
positive regulation of nucleoside metabolic processGO:0045979910.014
engulfment of apoptotic cellGO:004365230.014
nucleotide catabolic processGO:00091662170.014
positive regulation of cytosolic calcium ion concentrationGO:0007204650.014
placenta developmentGO:00018901400.014
negative regulation of ossificationGO:0030279490.014
nuclear transportGO:00511691390.014
retina development in camera type eyeGO:00600411190.014
t helper 2 cell cytokine productionGO:003574540.014
actin polymerization or depolymerizationGO:0008154540.014
ribonucleotide metabolic processGO:00092592910.014
vesicle organizationGO:0016050600.014
pancreatic a cell fate commitmentGO:000332620.014
positive regulation of neuron differentiationGO:00456661410.014
Mouse
regulation of lymphocyte activationGO:00512492400.014
male gamete generationGO:00482322850.014
purine nucleoside catabolic processGO:00061522050.014
regulation of eosinophil migrationGO:200041620.014
neural tube closureGO:0001843900.014
calcium ion transmembrane transportGO:0070588850.014
myeloid leukocyte differentiationGO:00025731190.014
positive regulation of cellular catabolic processGO:00313311480.013
regulation of postsynaptic membrane potentialGO:0060078480.013
nucleocytoplasmic transportGO:00069131390.013
macromolecule methylationGO:00434141200.013
cell fate determination involved in pattern specificationGO:006058210.013
nucleoside triphosphate catabolic processGO:00091432050.013
peptidyl amino acid modificationGO:00181933360.013
positive regulation of organelle organizationGO:00106381280.013
response to organic cyclic compoundGO:00140701980.013
cellular macromolecule catabolic processGO:00442652060.013
stem cell maintenanceGO:00198271300.013
chemotaxisGO:00069352470.013
rhythmic processGO:00485111740.013
glucose metabolic processGO:0006006920.013
nucleoside triphosphate metabolic processGO:00091412300.013
regulation of ras protein signal transductionGO:00465781140.013
oxidation reduction processGO:00551143420.013
carboxylic acid biosynthetic processGO:0046394860.013
regulation of cell morphogenesis involved in differentiationGO:00107691510.013
Mouse
heart processGO:0003015940.013
regulation of nucleotide metabolic processGO:00061401690.013
regulation of wnt signaling pathwayGO:00301111230.013
negative regulation of leukocyte differentiationGO:1902106510.013
primary neural tube formationGO:0014020950.013
av node cell to bundle of his cell communicationGO:008606720.013
sperm egg recognitionGO:0035036370.013
negative regulation of kinase activityGO:0033673810.013
response to painGO:0048265260.013
male gonad developmentGO:0008584880.013
zymogen activationGO:0031638410.013
protein localization to plasma membraneGO:0072659570.013
organic hydroxy compound biosynthetic processGO:1901617770.013
locomotory behaviorGO:00076261950.013
regulation of transferase activityGO:00513382630.012
positive regulation of hydrolase activityGO:00513451480.012
reactive oxygen species biosynthetic processGO:190340980.012
mesenchyme developmentGO:00604851520.012
neurotransmitter transportGO:0006836760.012
chromatin organizationGO:00063252060.012
response to insulinGO:00328681000.012
metanephros developmentGO:0001656790.012
multicellular organismal signalingGO:0035637910.012
membrane depolarizationGO:0051899640.012
gonad developmentGO:00084061410.012
Worm
cellular amide metabolic processGO:0043603580.012
regulation of blood circulationGO:1903522930.012
regulation of calcium ion transportGO:0051924690.012
positive regulation of sequence specific dna binding transcription factor activityGO:0051091680.012
mitotic cell cycleGO:00002781950.012
positive regulation of voltage gated calcium channel activityGO:190138720.012
positive regulation of protein complex assemblyGO:0031334450.012
glycoprotein biosynthetic processGO:0009101890.012
developmental cell growthGO:0048588840.012
Mouse
positive regulation of cell motilityGO:20001471160.012
regulation of t cell activationGO:00508631700.012
protein glycosylationGO:0006486550.012
cellular response to peptideGO:1901653920.012
nephron epithelium developmentGO:0072009920.012
regulation of hormone secretionGO:0046883880.012
regulation of anatomical structure sizeGO:00900661780.012
Mouse
heterocycle catabolic processGO:00467002800.012
organic anion transportGO:00157111370.012
epithelial cell developmentGO:00020641590.012
cell substrate adhesionGO:00315891300.012
positive regulation of neuron projection developmentGO:0010976790.012
response to metal ionGO:0010038470.012
appendage developmentGO:00487361660.012
establishment of synaptic vesicle localizationGO:0097480570.011
regulation of cellular component biogenesisGO:00440871810.011
trunk segmentationGO:003529040.011
regulation of cellular response to stressGO:00801351590.011
intracellular protein transportGO:00068862040.011
ventricular system developmentGO:0021591270.011
glucose transportGO:0015758560.011
proteolysis involved in cellular protein catabolic processGO:00516031470.011
axon ensheathmentGO:0008366760.011
limb developmentGO:00601731660.011
anion transmembrane transportGO:0098656710.011
sympathetic nervous system developmentGO:0048485220.011
regulation of ion transmembrane transportGO:00347651190.011
regulation of protein kinase activityGO:00458592320.011
macromolecule catabolic processGO:00090572810.011
negative regulation of cell activationGO:00508661110.011
positive regulation of glial cell proliferationGO:006025240.011
divalent inorganic cation transportGO:00725111780.011
cellular response to oxidative stressGO:0034599760.011
regulation of body fluid levelsGO:00508781620.011
cardiac right ventricle formationGO:000321930.011
regulation of cellular response to growth factor stimulusGO:0090287820.011
small molecule biosynthetic processGO:00442831320.011
t cell proliferationGO:00420981200.011
alcohol metabolic processGO:00060661160.011
cellular response to inorganic substanceGO:0071241370.011
carbohydrate transportGO:0008643620.011
response to peptide hormoneGO:00434341270.011
nephron developmentGO:00720061090.011
astrocyte differentiationGO:0048708430.011
bmp signaling pathwayGO:0030509930.011
cd4 positive alpha beta t cell cytokine productionGO:003574340.011
dna metabolic processGO:00062593030.011
fertilizationGO:00095661270.011
cellular response to transforming growth factor beta stimulusGO:0071560880.011
retina morphogenesis in camera type eyeGO:0060042450.011
monosaccharide transportGO:0015749580.011
cellular metal ion homeostasisGO:00068751510.011
release of sequestered calcium ion into cytosolGO:0051209420.011
nucleotide metabolic processGO:00091173320.011
sensory system developmentGO:004888030.011
cellularizationGO:000734910.011
negative regulation of epithelial cell proliferationGO:0050680640.011
leukocyte mediated cytotoxicityGO:0001909620.011
sensory perception of chemical stimulusGO:0007606510.011
endomembrane system organizationGO:00102561470.011
microtubule based processGO:00070172360.011
carbohydrate homeostasisGO:00335001280.011
monocarboxylic acid biosynthetic processGO:0072330610.011
regulation of engulfment of apoptotic cellGO:190107420.011
fatty acid biosynthetic processGO:0006633410.011
myelinationGO:0042552740.010
myelination in peripheral nervous systemGO:0022011190.010
regulation of transmembrane transportGO:00347621280.010
insulin receptor signaling pathwayGO:0008286490.010
pancreatic pp cell differentiationGO:000331220.010
adaptive immune responseGO:00022501550.010
blood circulationGO:00080151950.010
response to drugGO:0042493750.010
calcium ion homeostasisGO:00550741270.010
covalent chromatin modificationGO:00165691630.010
cell killingGO:0001906670.010
embryonic placenta developmentGO:0001892980.010
erythrocyte differentiationGO:0030218880.010
regulation of membrane depolarizationGO:0003254110.010
ensheathment of neuronsGO:0007272760.010
immunoglobulin productionGO:0002377730.010
peptide metabolic processGO:0006518460.010
lymphocyte proliferationGO:00466511640.010
aortic valve morphogenesisGO:000318040.010
male sex differentiationGO:00466611090.010
ubiquitin dependent protein catabolic processGO:00065111290.010
calcium ion transportGO:00068161590.010
regulation of protein transportGO:00512231630.010
negative regulation of blood vessel morphogenesisGO:2000181250.010
adult behaviorGO:00305341350.010
cellular response to metal ionGO:0071248310.010

Nkx6-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.066
organ system cancerDOID:005068600.066
disease of cellular proliferationDOID:1456600.066
nervous system diseaseDOID:86300.032
disease of anatomical entityDOID:700.032
central nervous system diseaseDOID:33100.029
phaeochromocytomaDOID:005077100.023
cell type benign neoplasmDOID:006008400.023
benign neoplasmDOID:006007200.023
neurodegenerative diseaseDOID:128900.023
urinary system diseaseDOID:1800.011