Mus musculus

126 known processes

Wdr5

WD repeat domain 5

(Aliases: AA408785,AA960360,Big-3,2410008O07Rik,Big)

Wdr5 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
chromatin modificationGO:00165681870.998
histone modificationGO:00165701590.996
histone methylationGO:0016571710.996
macromolecule methylationGO:00434141200.996
covalent chromatin modificationGO:00165691630.995
protein methylationGO:0006479810.986
internal protein amino acid acetylationGO:0006475420.984
Human Fly
chromatin organizationGO:00063252060.983
protein alkylationGO:0008213810.980
histone acetylationGO:0016573410.978
Human Fly
methylationGO:00322591340.966
transdifferentiationGO:006029010.961
Worm
histone h3 k4 methylationGO:0051568230.926
histone lysine methylationGO:0034968500.850
peptidyl lysine modificationGO:0018205770.812
Human Fly
chromatin silencingGO:0006342150.747
histone deubiquitinationGO:001657820.677
dna metabolic processGO:00062593030.659
peptidyl amino acid modificationGO:00181933360.629
Human Fly
mitotic cell cycleGO:00002781950.589
Fly
gene silencingGO:0016458380.534
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoterGO:007236470.534
internal peptidyl lysine acetylationGO:0018393420.534
Human Fly
peptidyl lysine acetylationGO:0018394450.521
Human Fly
chromatin mediated maintenance of transcriptionGO:004809620.476
cellular response to dna damage stimulusGO:00069742070.421
Fly
histone h3 acetylationGO:0043966140.402
Human
protein acylationGO:0043543640.376
Human Fly
negative regulation of gene expression epigeneticGO:0045814150.369
response to organic cyclic compoundGO:00140701980.339
positive regulation of gluconeogenesis by positive regulation of transcription from rna polymerase ii promoterGO:003594850.296
chromatin remodelingGO:0006338320.261
Fly
segmentationGO:0035282930.169
neural tube developmentGO:00219151600.168
regionalizationGO:00030023370.167
intracellular receptor signaling pathwayGO:0030522740.160
histone h4 acetylationGO:0043967100.146
Human
negative regulation of phosphorus metabolic processGO:00105631840.131
leukocyte differentiationGO:00025213420.130
protein deacetylationGO:0006476320.126
embryonic organ morphogenesisGO:00485622760.121
embryonic skeletal system morphogenesisGO:0048704910.119
stem cell developmentGO:00488642190.115
dendrite developmentGO:00163581150.115
positive regulation of transcription elongation from rna polymerase ii promoterGO:003296820.107
positive regulation of dna templated transcription elongationGO:003278620.103
blastocyst developmentGO:0001824800.100
regulation of protein stabilityGO:0031647520.099
signal transduction by p53 class mediatorGO:0072331510.095
cellular macromolecule catabolic processGO:00442652060.094
transcription from rna polymerase i promoterGO:0006360130.086
epithelial tube morphogenesisGO:00605623030.084
cytoplasmic transportGO:00164822340.084
regulation of transcription by chromatin organizationGO:003440100.082
histone h3 k14 acetylationGO:004415430.081
histone h3 k9 acetylationGO:004397050.081
dna alkylationGO:0006305430.079
dna methylationGO:0006306430.079
response to estrogenGO:0043627240.078
multi multicellular organism processGO:00447061090.078
regulation of histone methylationGO:0031060300.074
amine metabolic processGO:0009308450.074
gland developmentGO:00487323300.074
embryonic epithelial tube formationGO:00018381300.074
response to steroid hormoneGO:0048545560.073
regulation of mitotic cell cycleGO:00073461260.073
Fly
positive regulation of immature t cell proliferationGO:003309140.070
cellular ketone metabolic processGO:0042180840.069
nuclear divisionGO:00002801580.069
posttranscriptional regulation of gene expressionGO:00106081550.068
maturation of 5 8s rrnaGO:000046010.068
anatomical structure homeostasisGO:00602491450.065
blastocyst growthGO:0001832230.064
protein targetingGO:00066051430.063
negative regulation of molecular functionGO:00440922580.063
positive regulation of cellular amino acid metabolic processGO:004576430.062
regulation of chromosome organizationGO:0033044830.061
histone h4 k12 acetylationGO:004398320.060
telomere maintenanceGO:0000723190.060
forebrain developmentGO:00309003020.059
somitogenesisGO:0001756690.057
germ cell developmentGO:00072811850.057
mitotic cell cycle processGO:19030471590.057
Fly
embryonic skeletal system developmentGO:00487061200.056
ribonucleoside metabolic processGO:00091192450.056
purine containing compound metabolic processGO:00725213110.055
cellular amino acid metabolic processGO:00065201030.055
response to oxidative stressGO:00069791230.054
carbohydrate biosynthetic processGO:0016051740.053
axon target recognitionGO:000741240.053
morphogenesis of embryonic epitheliumGO:00163311590.052
establishment of protein localization to organelleGO:00725941180.052
oogenesisGO:0048477560.051
regulation of organelle organizationGO:00330432890.051
regulation of chromatin modificationGO:1903308570.050
neural tube closureGO:0001843900.050
ribose phosphate metabolic processGO:00196932910.050
gonad developmentGO:00084061410.048
Worm
macromolecule catabolic processGO:00090572810.048
regulation of cellular amino acid metabolic processGO:000652150.048
digestive tract developmentGO:00485651900.047
hexose metabolic processGO:0019318980.047
determination of adult lifespanGO:0008340110.046
Worm
tube closureGO:0060606910.045
regulation of carbohydrate biosynthetic processGO:0043255400.045
purine nucleoside metabolic processGO:00422782410.044
cellular carbohydrate metabolic processGO:00442621190.044
ribonucleoside triphosphate catabolic processGO:00092031990.042
regulation of histone modificationGO:0031056560.042
genitalia developmentGO:0048806370.042
positive regulation of chromatin modificationGO:1903310280.041
positive regulation of gluconeogenesisGO:0045722110.040
apoptotic signaling pathwayGO:00971903060.040
nucleoside phosphate metabolic processGO:00067533380.040
regulation of nucleoside metabolic processGO:00091181300.040
camera type eye developmentGO:00430102660.039
nucleoside triphosphate catabolic processGO:00091432050.039
skeletal system morphogenesisGO:00487052030.039
neural tube formationGO:00018411080.038
ribonucleotide metabolic processGO:00092592910.038
regulation of cellular amine metabolic processGO:0033238200.038
mitochondrion organizationGO:00070051340.037
lymphocyte differentiationGO:00300982420.037
nucleocytoplasmic transportGO:00069131390.036
nuclear transportGO:00511691390.036
negative regulation of phosphorylationGO:00423261660.036
cellular response to lipidGO:00713961450.035
regulation of chromatin organizationGO:1902275570.035
regulation of intracellular transportGO:00323861590.035
protein modification by small protein conjugation or removalGO:00706472070.035
regulation of cellular ketone metabolic processGO:0010565660.035
tube formationGO:00351481400.035
response to organonitrogen compoundGO:00102432460.034
regulation of kinase activityGO:00435492490.034
rna processingGO:00063961050.034
male gamete generationGO:00482322850.033
mesoderm developmentGO:00074981000.033
nucleoside metabolic processGO:00091162460.032
tubulin deacetylationGO:009004240.031
glycosyl compound metabolic processGO:19016572460.030
negative regulation of cell proliferationGO:00082852960.030
multicellular organism growthGO:00352641610.030
organelle fissionGO:00482851700.030
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formationGO:006082310.030
stem cell maintenanceGO:00198271300.030
wnt signaling pathwayGO:00160551880.030
negative regulation of cell cycleGO:00457861230.030
Fly
female gamete generationGO:0007292740.030
monosaccharide biosynthetic processGO:0046364440.029
positive regulation of transcription from rna polymerase i promoterGO:004594330.029
negative regulation of protein modification processGO:00314001630.029
protein catabolic processGO:00301632210.028
ribosomal small subunit biogenesisGO:004227440.028
histone h2a monoubiquitinationGO:003551810.028
axonogenesisGO:00074092740.028
male sex differentiationGO:00466611090.028
developmental maturationGO:00217001930.028
negative regulation of cellular component organizationGO:00511291940.027
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:000046610.027
small gtpase mediated signal transductionGO:0007264970.026
cellular amine metabolic processGO:0044106440.026
response to peptideGO:19016521360.025
mrna splicing via spliceosomeGO:0000398430.025
homeostasis of number of cellsGO:00488722100.025
negative regulation of protein serine threonine kinase activityGO:0071901490.025
organonitrogen compound catabolic processGO:19015652640.024
cell fate commitmentGO:00451652100.024
inner cell mass cell proliferationGO:0001833150.024
sensory perceptionGO:00076002450.023
regulation of cytoplasmic transportGO:19036491120.023
regulation of cell cycle g1 s phase transitionGO:1902806350.023
regulation of mitotic cell cycle phase transitionGO:1901990730.023
Fly
nucleotide metabolic processGO:00091173320.022
nucleoside phosphate catabolic processGO:19012922220.022
t cell activationGO:00421102890.022
telencephalon developmentGO:00215371860.021
negative regulation of phosphate metabolic processGO:00459361840.021
urogenital system developmentGO:00016552610.021
nucleoside monophosphate metabolic processGO:0009123850.021
protein import into nucleusGO:0006606950.021
regulation of intracellular protein transportGO:0033157820.021
g1 s transition of mitotic cell cycleGO:0000082570.021
nucleoside catabolic processGO:00091642060.021
purine ribonucleoside metabolic processGO:00461282410.021
histone h2a ubiquitinationGO:003352230.021
regulation of leukocyte differentiationGO:19021051590.021
meiosis iGO:0007127600.021
skeletal system developmentGO:00015013560.021
hindbrain developmentGO:00309021280.020
purine nucleoside triphosphate metabolic processGO:00091442260.020
negative regulation of cyclin dependent protein serine threonine kinase activityGO:004573690.020
spermatogenesisGO:00072832840.020
response to light stimulusGO:00094161350.020
regulation of glucose metabolic processGO:0010906600.020
somite developmentGO:0061053810.020
positive regulation of cellular amine metabolic processGO:003324050.019
circadian regulation of gene expressionGO:0032922480.019
regulation of cell activationGO:00508652890.019
purine nucleoside triphosphate catabolic processGO:00091462030.019
positive regulation of b cell activationGO:0050871490.019
response to acid chemicalGO:00011011110.019
transmembrane receptor protein serine threonine kinase signaling pathwayGO:00071781940.019
protein localization to nucleusGO:00345041210.018
positive regulation of cell activationGO:00508671580.018
regulation of sequence specific dna binding transcription factor activityGO:00510901060.018
dna damage response signal transduction by p53 class mediatorGO:0030330190.018
development of primary male sexual characteristicsGO:0046546880.018
primary neural tube formationGO:0014020950.018
ribonucleoside triphosphate metabolic processGO:00091992200.018
canonical wnt signaling pathwayGO:00600701300.017
mitotic nuclear divisionGO:0007067480.017
nucleus organizationGO:0006997450.017
purine ribonucleotide metabolic processGO:00091502900.017
gastrulationGO:00073691160.017
monosaccharide metabolic processGO:00059961060.017
cell adhesionGO:00071553290.017
rna interferenceGO:001624620.017
ras protein signal transductionGO:0007265770.017
stem cell differentiationGO:00488632680.016
protein importGO:00170381010.016
production of molecular mediator of immune responseGO:00024401030.016
purine nucleotide metabolic processGO:00061633020.016
single organism nuclear importGO:1902593950.016
regulation of purine nucleotide metabolic processGO:19005421690.016
rrna processingGO:0006364100.016
intracellular protein transportGO:00068862040.016
rna 5 end processingGO:000096610.016
carbohydrate derivative catabolic processGO:19011362310.016
purine ribonucleoside triphosphate catabolic processGO:00092071990.016
purine ribonucleoside catabolic processGO:00461302050.016
positive regulation of intracellular protein transportGO:0090316420.016
positive regulation of cellular carbohydrate metabolic processGO:0010676290.016
leukocyte mediated immunityGO:00024431740.016
regulation of t cell activationGO:00508631700.016
regulation of cell cycle processGO:00105641600.016
Fly
maintenance of locationGO:0051235890.015
connective tissue developmentGO:00614481790.015
regulation of wnt signaling pathwayGO:00301111230.015
cell cycle g1 s phase transitionGO:0044843570.015
ossificationGO:00015032160.015
regulation of hydrolase activityGO:00513362460.015
adaptive immune responseGO:00022501550.015
digestive system developmentGO:00551232000.015
central nervous system neuron differentiationGO:00219531620.015
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:000046210.015
nucleotide catabolic processGO:00091662170.015
developmental growth involved in morphogenesisGO:00605601380.015
negative regulation of protein metabolic processGO:00512482820.015
cell maturationGO:00484691270.015
purine nucleoside catabolic processGO:00061522050.015
intracellular mrna localizationGO:000829840.015
pharynx developmentGO:006046510.015
cell cycle arrestGO:0007050370.015
cellular protein complex assemblyGO:00436231160.015
organonitrogen compound biosynthetic processGO:19015661920.015
histone deacetylationGO:0016575260.015
myeloid cell differentiationGO:00300992330.015
response to peptide hormoneGO:00434341270.014
single organism cell adhesionGO:00986021560.014
purine containing compound catabolic processGO:00725232130.014
purine ribonucleoside triphosphate metabolic processGO:00092052200.014
positive regulation of leukocyte mediated immunityGO:0002705700.014
regulation of cellular catabolic processGO:00313292420.014
regulation of nucleotide metabolic processGO:00061401690.014
branching morphogenesis of an epithelial tubeGO:00487541590.014
purine nucleotide catabolic processGO:00061952110.014
regulation of proteolysisGO:00301621640.014
positive regulation of leukocyte differentiationGO:1902107860.014
regulation of epithelial cell proliferationGO:00506781410.014
negative regulation of apoptotic signaling pathwayGO:20012341040.014
regulation of myeloid cell differentiationGO:0045637960.014
rna catabolic processGO:0006401290.014
cellular protein catabolic processGO:00442571550.014
proteasomal protein catabolic processGO:0010498980.014
chromatin silencing at rdnaGO:000018330.014
blood vessel morphogenesisGO:00485142850.014
striated muscle tissue developmentGO:00147062930.013
nucleoside triphosphate metabolic processGO:00091412300.013
demethylationGO:0070988230.013
regulation of heart induction by regulation of canonical wnt signaling pathwayGO:009008120.013
positive regulation of growthGO:00459271040.013
leukocyte activation involved in immune responseGO:00023661260.013
columnar cuboidal epithelial cell differentiationGO:0002065820.013
digestive tract morphogenesisGO:00485461470.013
nucleobase containing small molecule metabolic processGO:00550863520.013
hexose biosynthetic processGO:0019319390.013
cell type specific apoptotic processGO:00972852680.013
dna templated transcription elongationGO:0006354130.013
positive regulation of lymphocyte mediated immunityGO:0002708620.013
regulation of mrna metabolic processGO:1903311430.013
microtubule based processGO:00070172360.013
atp metabolic processGO:0046034750.013
histone h4 k16 acetylationGO:004398430.012
Human
muscle tissue developmentGO:00605373080.012
cation transportGO:00068123990.012
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:0002822870.012
retina development in camera type eyeGO:00600411190.012
cellular response to acid chemicalGO:0071229680.012
protein ubiquitinationGO:00165671710.012
regulation of peptidyl lysine acetylationGO:2000756220.012
positive regulation of lymphocyte differentiationGO:0045621610.012
circulatory system processGO:00030131970.012
locomotory behaviorGO:00076261950.012
cell activation involved in immune responseGO:00022631260.012
dna modificationGO:0006304500.012
glycosyl compound catabolic processGO:19016582060.012
heterocycle catabolic processGO:00467002800.012
humoral immune responseGO:0006959570.012
positive regulation of protein modification processGO:00314012990.012
regulation of transcription from rna polymerase iii promoterGO:000635920.012
meiotic cell cycleGO:00513211220.012
snorna metabolic processGO:001607410.012
response to radiationGO:00093141650.012
aromatic compound catabolic processGO:00194392860.012
positive regulation of cell deathGO:00109422240.012
leukocyte proliferationGO:00706611720.012
neuron deathGO:00709971540.012
modification dependent macromolecule catabolic processGO:00436321330.012
lymphocyte mediated immunityGO:00024491390.012
negative regulation of cellular protein metabolic processGO:00322692470.012
negative regulation of cell cycle processGO:0010948690.012
Fly
positive regulation of carbohydrate metabolic processGO:0045913300.012
positive regulation of apoptotic processGO:00430652170.012
negative regulation of ossificationGO:0030279490.012
double strand break repairGO:0006302480.012
cellular response to organonitrogen compoundGO:00714171450.011
response to osmotic stressGO:0006970210.011
negative regulation of sequence specific dna binding transcription factor activityGO:0043433400.011
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090100430.011
positive regulation of lymphocyte activationGO:00512511400.011
tissue remodelingGO:00487711020.011
histone h3 k36 methylationGO:001045260.011
positive regulation of programmed cell deathGO:00430682180.011
steroid metabolic processGO:00082021190.011
ribonucleoprotein complex subunit organizationGO:0071826280.011
epithelial cell proliferationGO:00506731740.011
negative regulation of mitotic cell cycleGO:0045930580.011
Fly
regulation of protein catabolic processGO:00421761080.011
mammary gland epithelium developmentGO:0061180650.011
somatic diversification of immune receptors via germline recombination within a single locusGO:0002562510.011
cellular response to organic cyclic compoundGO:0071407870.011
regulation of histone h3 k36 methylationGO:000041410.011
regulation of lymphocyte activationGO:00512492400.011
maternal process involved in female pregnancyGO:0060135320.011
wound healingGO:00420601570.011
ribonucleoside catabolic processGO:00424542060.011
regulation of cellular component biogenesisGO:00440871810.011
learning or memoryGO:00076111480.011
regulation of protein targetingGO:1903533610.011
regulation of leukocyte proliferationGO:00706631210.011
protein deubiquitinationGO:0016579190.011
regulation of antimicrobial humoral responseGO:000275930.011
organic cyclic compound catabolic processGO:19013612950.010
tricuspid valve developmentGO:000317530.010
mrna transcriptionGO:000929940.010
cleavage involved in rrna processingGO:000046910.010
respiratory system developmentGO:00605411900.010
regulation of protein processingGO:0070613960.010
positive regulation of hydrolase activityGO:00513451480.010
regulation of cell migrationGO:00303342190.010
mapk cascadeGO:00001652810.010
regulation of cyclin dependent protein serine threonine kinase activityGO:0000079160.010
endonucleolytic cleavage of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:000047910.010
protein localization to organelleGO:00333651850.010
purine ribonucleoside monophosphate metabolic processGO:0009167800.010
t cell differentiationGO:00302171740.010
regulation of lymphocyte mediated immunityGO:0002706840.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:00024601450.010
metaphase plate congressionGO:005131020.010
protein modification by small protein conjugationGO:00324461870.010

Wdr5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.052
nervous system diseaseDOID:86300.052
eye and adnexa diseaseDOID:149200.030
sensory system diseaseDOID:005015500.030
eye diseaseDOID:561400.028
central nervous system diseaseDOID:33100.021
retinal degenerationDOID:846600.014
retinal diseaseDOID:567900.014
disease of mental healthDOID:15000.012
neurodegenerative diseaseDOID:128900.011